MCID: MTS001
MIFTS: 48

Mutism malady

Fetal diseases category
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Summaries for Mutism

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Muteness or mutism (from Latin mutus, meaning \"silent\") is an inability to speak caused by a speech... more...

MalaCards: Mutism is related to akinetic mutism and schizophrenia. An important gene associated with Mutism is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways are Fatty acid metabolism and Biosynthesis of unsaturated fatty acids. The compounds plp (139-151) and c3bot (154-182) have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related mouse phenotypes are normal and reproductive system.

Disease Ontology:8 A speech disorder that involves a complete inability to speak.

Aliases & Classifications for Mutism

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

mutism 8 10 62


External Ids:

Disease Ontology8 DOID:4189
SNOMED-CT58 88052002, 267771000
MeSH35 D009155

Related Diseases for Mutism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mutism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 347)
idRelated DiseaseScoreTop Affiliating Genes
1akinetic mutism31.2PNMA2, TXNDC9, PRNP, ACAA2, MBP
2schizophrenia30.5SLC6A3, MBP
3pendred syndrome29.8GJB2
4wilson disease29.8SLC6A3, PRNP
5encephalitis29.7PNMA2, CNTNAP2, MBP
6elective mutism10.7
7cerebritis10.4
8medulloblastoma10.2
9social phobia10.2
10brain stem infarction10.2
11posterior fossa tumors10.2
12hydrocephalus10.1
13cerebral artery occlusion10.1
14obstructive hydrocephalus10.1
15anxiety disorder10.1
16mental retardation10.1
17head injury10.1
18prion disease10.1TXNDC9, PNMA2
19aids dementia complex10.1SLC6A3, MBP
20vascular dementia10.1MBP, PRNP
21progressive supranuclear palsy10.1PRNP, SLC6A3
22lewy body dementia10.1SLC6A3, PRNP
23central nervous system disease10.0SLC6A3, MBP
24memory impairment10.0SLC6A3, PRNP
25movement disease10.0ATP1A3, SLC6A3
26gilles de la tourette syndrome10.0CNTNAP2, SLC6A3
27multiple system atrophy10.0PRNP, MBP, SLC6A3
28epilepsy syndrome10.0SLC6A3, MBP, PRNP
29apraxia10.0
30goiter10.0
31hemangioblastoma10.0
32keratoderma10.0
33dysphagia10.0
34waardenburg's syndrome10.0MITF, GJB2
35zellweger syndrome10.0ACAA2, ACOX3
36neurofibroma10.0MBP, MITF
37toxic encephalopathy10.0PRNP, SLC6A3
38brain disease10.0MBP, PRNP
39neurilemmoma10.0MBP, MITF
40sensorineural hearing loss10.0GJB2, MITF
41x-linked ichthyosis9.9
42acute disseminated encephalomyelitis9.9
43creutzfeldt-jakob disease9.9
44choroiditis9.9
45basilar artery occlusion9.9
46anterior cerebral artery infarction9.9
47fragile x syndrome9.9
48aphasia9.9
49astrocytoma9.9
50cerebellar medulloblastoma9.9

Graphical network of the top 20 diseases related to Mutism:



Diseases related to mutism

Symptoms for Mutism

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Drugs & Therapeutics for Mutism

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mutism

Search NIH Clinical Center for Mutism

Genetic Tests for Mutism

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Anatomical Context for Mutism

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33MalaCards
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MalaCards organs/tissues related to Mutism:

33
Brain, Liver, Bone, Lung, Bone marrow, Skin, Thyroid, Heart, Testes, Eye, Tongue, Appendix

Animal Models for Mutism or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mutism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8SLC6A3, MBP, GJB2, MITF, PRNP
2MP:00053898.6SLC6A3, MBP, GJB2, MITF, PRNP, FANCL
3MP:00053868.3ATP1A3, PRNP, MITF, CNTNAP2, MBP, SLC6A3
4MP:00053788.3ATP1A3, FANCL, PRNP, MITF, CNTNAP2, GJB2
5MP:00036318.2ATP1A3, PRNP, MITF, CNTNAP2, GJB2, MBP
6MP:00053768.2ATP1A3, FANCL, PRNP, MITF, GJB2, MBP
7MP:00053848.1FANCL, PRNP, CNTNAP2, GJB2, MBP, SLC6A3
8MP:00107688.0ATP1A3, FANCL, PRNP, MITF, GJB2, MBP

Publications for Mutism

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52PubMed
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Articles related to Mutism:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Cerebellar Mutism Caused by Primary Varicella Infection in an Immunocompetent Child. (23446802)
2013
2
Cerebellar mutism. (23398780)
2013
3
Selective mutism: a team approach to assessment and treatment in the school setting. (21970860)
2012
4
Dysarthria and mutism. (22377870)
2012
5
Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate. (22672948)
2012
6
Vegetative state, minimally conscious state, akinetic mutism and Parkinsonism as a continuum of recovery from disorders of consciousness: an exploratory and preliminary study. (21693084)
2011
7
Acute mutism: a useful lesson. (20659887)
2011
8
Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. (20713408)
2010
9
Cerebellar mutism in pediatric acute disseminated encephalomyelitis. (20304329)
2010
10
Transient mutism and pathologic laughter in the course of cerebellitis. (19520276)
2009
11
Persistent akinetic mutism after bilateral paramedian thalamic infarction. (19776325)
2009
12
Increased left prefrontal activation during staring/mutism episodes in a patient with resistant catatonic schizophrenia: a near infrared spectroscopy study. (18327023)
2008
13
Treatment of akinetic mutism with intramuscular olanzapine: a case series. (18305290)
2008
14
Hysterical mutism associated with a diagnosis of lung cancer. (17878510)
2007
15
Clinical case rounds in child and adolescent psychiatry: commentary on selective mutism. (18392159)
2007
16
Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report. (16509510)
2006
17
Practitioner review: Psychosocial interventions for children with selective mutism: a critical evaluation of the literature from 1990-2005. (17076747)
2006
18
Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison's disease. (16682841)
2006
19
Behavioral and emotional adjustment, family functioning, academic performance, and social relationships in children with selective mutism. (15482497)
2004
20
Mutism as a complication of total intravenous anesthesia by propofol. (14633577)
2003
21
Prevalence and description of selective mutism in immigrant and native families: a controlled study. (14627880)
2003
22
Selective mutism and obsessive compulsive disorders associated with zonisamide. (12237077)
2002
23
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. (11983799)
2002
24
Elective mutism: effect of dental treatment with N2/O2-inhalation sedation: review and report of case. (10360207)
1999
25
Selective mutism. (10071945)
1999
26
A double-blind comparison of lorazepam and oxazepam in psychomotor retardation and mutism. (10435212)
1999
27
Transient mutism after brain stem infarction (ref. Acta Neurochirurgia 1999, 141: 209-213) (10536732)
1999
28
Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma. (9856479)
1998
29
Case study: audio feedforward treatment of selective mutism. (9444898)
1998
30
Cyclosporine mutism. (9008554)
1997
31
Mutilating keratoderma with deaf-mutism. (20948071)
1996
32
Elective mutism: an analysis of 100 cases. (8935207)
1996
33
Cerebellar mutism following posterior fossa tumour surgery. (8861318)
1996
34
Fluoxetine for (s)elective mutism. (7608040)
1995
35
The syndrome of 'cerebellar' mutism and subsequent dysarthria. (7969956)
1994
36
Transient mutism after posterior fossa surgery. (7923241)
1994
37
Transient mutism following posterior fossa surgery in children. (8121185)
1994
38
A parent comments on elective mutism. (8496136)
1993
39
Elective mutism and mental retardation. (8340310)
1993
40
Is elective mutism a social phobia? (8407760)
1993
41
Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings. (1573414)
1992
42
Treatment of a case of akinetic mutism with bromocriptine. (2136401)
1990
43
Labeling and functional language in a case of psychological mutism. (3667955)
1987
44
Mutism, malingering, and competency to stand trial. (3676530)
1987
45
Mutism following left hemisphere infarction. (6210346)
1984
46
Elective mutism in a 26 year old deaf female. (6839269)
1983
47
Articulatory recovery after traumatic mutism. (6654280)
1983
48
Elective mutism. (420040)
1979
49
Mutism in infantile autism, schizophrenia and manic-depressive states: the correlation of clinical psychopathology and linguistics. (4448605)
1974
50
DIAGNOSIS AND TREATMENT OF ELECTIVE MUTISM IN CHILDREN. (14281154)
1964

Variations for Mutism

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Expression for genes affiliated with Mutism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mutism

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Pathways for genes affiliated with Mutism

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Mutism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.1ACAA2, ACOX3
2
Show member pathways
oleate biosynthesis II (animals)38
9.1ACAA2, ACOX3

Compounds for genes affiliated with Mutism

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61Tocris Bioscience, 45Novoseek, 24HMDB, 11DrugBank
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Compounds related to Mutism according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1plp (139-151)6110.0MBP, PRNP
2c3bot (154-182)6110.0PRNP, MBP
3ono 25066110.0PRNP, MBP
4nogo-66 (1-40)619.9PRNP, MBP
5mog (35-55)619.9PRNP, MBP
6hemocyanin459.7MBP, PRNP
7potassium45 24 1111.5GJB2, CNTNAP2, ATP1A3
8Tetradecanoyl-CoA249.2ACAA2, ACOX3
9paraffin459.2PRNP, MITF, GJB2, MBP
10aspartate459.2PRNP, GJB2, MBP, SLC6A3
11arginine459.0PRNP, MITF, MBP, SLC6A3
12glutamate458.8SLC6A3, MBP, MITF, PRNP

GO Terms for genes affiliated with Mutism

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16Gene Ontology
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Cellular components related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.3SLC6A3, MBP, CNTNAP2
2axonGO:0304249.1SLC6A3, CNTNAP2, ATP1A3

Molecular functions related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.7SLC6A3, MBP

Products for genes affiliated with Mutism

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Sources for Mutism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet