Aliases & Classifications for Mutism

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Aliases & Descriptions for Mutism:

Name: Mutism 11 27 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:4189
SNOMED-CT62 267771000, 88052002
MeSH39 D009155

Summaries for Mutism

About this section
Disease Ontology:11 A speech disorder that involves a complete inability to speak.

MalaCards based summary: Mutism is related to elective mutism and akinetic mutism, and has symptoms including aphonia, drooling and fatigue. An important gene associated with Mutism is CNTNAP2 (Contactin Associated Protein-Like 2). Affiliated tissues include brain, liver and bone, and related mouse phenotypes are pigmentation and integument.

Related Diseases for Mutism

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Diseases related to Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1elective mutism12.4
2akinetic mutism12.3
3anxiety disorder11.1
4dementia, familial, nonspecific10.8
5dementia, frontotemporal10.8
6syndromic x-linked intellectual disability 1210.8
7symbrachydactyly of hands and feet10.2CHMP2B, GRN
8testicular seminoma10.2CHMP2B, GRN
9andersen syndrome10.2CHMP2B, GRN
10retrograde amnesia10.1CHMP2B, GRN
11balo concentric sclerosis10.1CHMP2B, GRN
12periodic limb movement disorder10.1CNTNAP2, GRN
13cerebritis10.1
14colon kaposi sarcoma10.1CHMP2B, GRN
15adrenal gland pheochromocytoma10.1CHMP2B, SLC6A3
16nosophobia10.1CHMP2B, GRN
17schizophrenia10.0
18perry syndrome10.0GRN, SLC6A3
19tendinopathy9.9CNTNAP2, GRN
20medulloblastoma9.9
21social phobia9.9
22pick disease9.9CHMP2B, GRN
23meier-gorlin syndrome 59.9GRN, SLC6A3
24parkinson disease 19.9GRN, SLC6A3
25brain stem infarction9.9
26pervasive developmental disorder9.9GRN, SLC6A3
27osteogenesis imperfecta, type ix9.9CNTNAP2, SLC6A3
28hydrocephalus9.8
29head injury9.8
30apraxia9.8
31cerebral artery occlusion9.8
32obstructive hydrocephalus9.8
33adult brain stem glioma9.8ATP1A3, SLC6A3
34goiter9.7
35astrocytoma9.7
36hemangioblastoma9.7
37acute disseminated encephalomyelitis9.7
38dysphagia9.7
39encephalopathy9.7
40avoidant personality disorder9.7GRN, SLC6A3
41chronic intestinal vascular insufficiency9.7GJB2, GRN, SLC6A3
42endometritis9.6ATP1A3, GJB2
43lung cancer9.6
44creutzfeldt-jakob disease9.6
45brain injury9.6
46aphasia9.6
47cerebellar medulloblastoma9.6
48choroiditis9.6
49paranoid schizophrenia9.6
50basilar artery occlusion9.6

Graphical network of the top 20 diseases related to Mutism:



Diseases related to mutism

Symptoms & Phenotypes for Mutism

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UMLS symptoms related to Mutism:


aphonia, drooling, fatigue, sleep disturbances, photophobia, neologism, aprosodia, personality change, scanning speech, speech and language abnormalities, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Mutism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6FANCL, GRN, MITF
2MP:00107719.1CNTNAP2, FANCL, GJB2, MITF, SLC6A3
3MP:00053848.5CNTNAP2, FANCL, GJB2, GRN, MITF, SLC6A3
4MP:00053788.2ATP1A3, CNTNAP2, FANCL, GJB2, MITF, SLC6A3
5MP:00053898.0FANCL, GJB2, GRN, MITF, SLC6A3
6MP:00036317.7ATP1A3, CHMP2B, CNTNAP2, GJB2, GRN, MITF

Drugs & Therapeutics for Mutism

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Drugs for Mutism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fluoxetineapproved, vet_approvedPhase 323554910-89-33386
Synonyms:
(+) or (-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+) or (-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+/-)-Fluoxetine
(+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine
(+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]
(+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine
3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
52341-67-0
54910-89-3
57226-07-0
59333-67-4 (hydrochloride)
AB00053774
AC-14564
AC1L1FTH
AKOS003663021
Adofen
Animex-On
BPBio1_000354
BPBio1_000509
BRD-A31159102-001-01-9
BRD-A31159102-003-05-6
BSPBio_000461
BSPBio_003375
Bio-0787
Biomol-NT_000152
C17H18F3NO
CHEBI:5118
CHEMBL41
CID3386
D00326
DB00472
Deprex
DivK1c_006819
Eufor
Floxetine
Fluctin
Fluoxeren
Fluoxetin
Fluoxetina
Fluoxetina [INN-Spanish]
Fluoxetina [Spanish]
Fluoxetine (TN)
Fluoxetine (USAN/INN)
Fluoxetine Hcl
Fluoxetine Hydrochloride
Fluoxetine [USAN:INN:BAN]
Fluoxetinum
 
Fluoxetinum [INN-Latin]
Fluoxétine
Fluval
Fontex
Foxetin
HMS2090H14
KBio1_001763
KBio2_002159
KBio2_004727
KBio2_007295
KBio3_002595
KBioGR_001166
KBioSS_002159
L000931
LS-31040
Lilly-110140
Lopac0_000558
Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine
MolPort-001-683-482
N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine
NCGC00015428-10
NCGC00024879-03
NCGC00024879-04
NSC283480
Portal
Prestwick0_000511
Prestwick1_000511
Prestwick2_000511
Prestwick3_000511
Prozac
Prozac Weekly
Pulvules
Reconcile
Reneuron
SPBio_001815
SPBio_002382
STK734483
Sarafem
SpecPlus_000723
Spectrum2_001658
Spectrum3_001648
Spectrum4_000613
Spectrum5_001518
Spectrum_001679
TL8003595
UNII-01K63SUP8D
dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
fluoxetine
fluoxetine (Prozac)
nchembio.534-comp2
2Psychotropic DrugsPhase 36279
3
SerotoninPhase 3356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
4Serotonin AgentsPhase 33102
5Serotonin Uptake InhibitorsPhase 31570
6Neurotransmitter Uptake InhibitorsPhase 33464
7Neurotransmitter AgentsPhase 317734
8Antidepressive Agents, Second-GenerationPhase 31287
9Antidepressive AgentsPhase 32666
10Cytochrome P-450 CYP2D6 InhibitorsPhase 3716
11Cytochrome P-450 Enzyme InhibitorsPhase 33822
12
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Treatment of Childhood Social PhobiaCompletedNCT00043537Phase 3
2Randomised Controlled Treatment Study of Selective MutismCompletedNCT01002196Phase 2
3Brief Behavioral Treatment for Anxiety in Young ChildrenCompletedNCT02051192Phase 1, Phase 2
4Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and AnxietyCompletedNCT01187784Phase 1
5Posterior Fossa Mutism on Quality of LifeCompletedNCT02048176
6Integrated Behavioral Therapy for Treating Children With Selective MutismCompletedNCT00458198
7Web-Based CBT Protocol for Treatment of Selective MutismCompletedNCT02009839
8What Treatment Works for Children With Selective Mutism?CompletedNCT00554749
9Cerebellar Mutism Syndrome StudyRecruitingNCT02300766
10Treatment of Social Anxiety Disorder and Selective MutismRecruitingNCT02554929
11Functional Imaging of Cerebellar Mutism SyndromeRecruitingNCT01733173
12Vagal Nerve Stimulation in Coma PatientsRecruitingNCT02591069
13Treating Refractory Schizophrenia With rTMSRecruitingNCT02242578
14DTI & Tractography in Pediatric Tumor SurgeryNot yet recruitingNCT02810626

Search NIH Clinical Center for Mutism


Cochrane evidence based reviews: mutism

Genetic Tests for Mutism

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Genetic tests related to Mutism:

id Genetic test Affiliating Genes
1 Mutism27

Anatomical Context for Mutism

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MalaCards organs/tissues related to Mutism:

36
Brain, Liver, Bone, Neutrophil, Thyroid, Bone marrow, Lung

Publications for Mutism

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Articles related to Mutism:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. (27977468)
2017
2
Apraxia of speech and cerebellar mutism syndrome: a case report. (28074148)
2017
3
Sudden benzodiazepine-induced resolution of post-operative pediatric cerebellar mutism syndrome: a clinical-SPECT study. (28050719)
2017
4
Pediatric selective mutism therapy: a randomized controlled trial. (27830922)
2016
5
Augmentative and Alternative Communication (AAC) for a patient with a nonfluent/ agrammatic variant of PPA in the mutism stage. (27007540)
2016
6
126a88Anatomy of Cerebellar Mutism: Reduced Fractional Anisotropy in the Superior Cerebellar Peduncle. (27399405)
2016
7
Anxiety and oppositional behavior profiles among youth with selective mutism. (26625009)
2016
8
Selective mutism. (26709680)
2016
9
Selective Mutism: The Fraternal Twin of Childhood Social Phobia. (27089281)
2016
10
Social Communication Anxiety Treatment (S-CAT) for children and families with selective mutism: A pilot study. (26940121)
2016
11
Acquired Mutism and Hypertonia in a Toddler. (27364777)
2016
12
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. (27418987)
2016
13
Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease. (27646053)
2016
14
Identifying Treatment Response of Sertraline in a Teenager with Selective Mutism using Electrophysiological Neuroimaging. (27468379)
2016
15
A Case of Mutism in Noncatatonic Schizophrenia Responding to Small Dose of Fluvoxamine Addition to Clozapine. (27508430)
2016
16
Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results. (27142103)
2016
17
Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. (27942473)
2016
18
Selective mutism and temperament: the silence and behavioral inhibition to the unfamiliar. (26970743)
2016
19
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. (26825206)
2016
20
Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation. (27069898)
2016
21
A case of mutism on emergence from general anesthesia. (26872966)
2016
22
Akinetic mutism revealing an ischemic stroke. (27955795)
2016
23
Absence of Nails, Deaf-mutism, Seizures, and Intellectual Disability: A Case Report. (26023614)
2015
24
A Selective Mutism Arising from First Language Attrition, Successfully Treated with Paroxetine-CBT Combination Treatment. (26508972)
2015
25
Ties of silence - Family lived experience of selective mutism in identical twins. (26092264)
2015
26
Remarkable improvement of selective mutism with everolimus in a patient with tuberous sclerosis complex. (25784638)
2015
27
The outcome of children with selective mutism following cognitive behavioral intervention: a follow-up study. (26498645)
2015
28
Children of Few Words: Relations Among Selective Mutism, Behavioral Inhibition, and (Social) Anxiety Symptoms in 3- to 6-Year-Olds. (25842046)
2015
29
Children Who are Anxious in Silence: A Review on Selective Mutism, the New Anxiety Disorder in DSM-5. (25724675)
2015
30
Cerebellar mutism. (26351234)
2015
31
Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. (26145481)
2015
32
Mutism in non-catatonic schizophrenia: Psychotic symptom and adaptive behavioral strategy. (26144881)
2015
33
Cerebellar mutism following closed head injury in a child. (25685374)
2015
34
Mumps encephalitis with akinesia and mutism. (25809834)
2015
35
The use of medication in selective mutism: a systematic review. (26560144)
2015
36
An auditory-neuroscience perspective on the development of selective mutism. (25625220)
2015
37
Cerebellar mutism after posterior fossa tumor resection: case discussion and recommendations for psychoeducational intervention. (24608700)
2014
38
Unique presentation of akinetic mutism and coexisting thyroid storm relating to stroke. (25530892)
2014
39
The anatomical substrate of cerebellar mutism. (24735842)
2014
40
Cerebellar mutism in acute disseminating encephalomyelitis. (24656209)
2014
41
Fluorodeoxyglucose positron emission tomography/computed tomography findings in a patient with cerebellar mutism after operation in posterior fossa. (24650725)
2014
42
A girl with tuberous sclerosis complex presenting with severe epilepsy and electrical status epilepticus during sleep, and with high-functioning autism and mutism. (24968009)
2014
43
Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session. (25535609)
2014
44
Selective mutism: follow-up study 1A year after end of treatment. (25267381)
2014
45
Cerebellar mutism: the rehabilitation challenge in pediatric neuro-oncology: case studies. (25547885)
2014
46
Cause and outcome of cerebellar mutism: evidence from a systematic review. (24452481)
2014
47
Cerebellar Mutism Caused by Primary Varicella Infection in an Immunocompetent Child. (23446802)
2013
48
Cerebellar mutism. (23398780)
2013
49
Telephone effect in akinetic mutism from traumatic brain injury. (23932533)
2013
50
Parental adjustment, parenting attitudes and emotional and behavioral problems in children with selective mutism. (23247199)
2013

Variations for Mutism

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Expression for genes affiliated with Mutism

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Search GEO for disease gene expression data for Mutism.

Pathways for genes affiliated with Mutism

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GO Terms for genes affiliated with Mutism

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Cellular components related to Mutism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304248.8ATP1A3, CNTNAP2, SLC6A3

Sources for Mutism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet