Aliases & Classifications for Mutism

MalaCards integrated aliases for Mutism:

Name: Mutism 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4189
MeSH 42 D009155
SNOMED-CT 64 267771000 88052002
UMLS 69 C0026884

Summaries for Mutism

Disease Ontology : 12 A speech disorder that involves a complete inability to speak.

MalaCards based summary : Mutism is related to elective mutism and akinetic mutism, and has symptoms including aphonia, fatigue and sleep disturbances. An important gene associated with Mutism is SHANK3 (SH3 And Multiple Ankyrin Repeat Domains 3). The drugs Fluoxetine and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are integument and nervous system

Related Diseases for Mutism

Diseases related to Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 elective mutism 12.3
2 akinetic mutism 12.3
3 anxiety disorder 11.1
4 dementia, familial, nonspecific 10.7
5 dementia, frontotemporal 10.7
6 syndromic x-linked intellectual disability 12 10.7
7 central pontine myelinolysis 10.7
8 short stature deafness neutrophil dysfunction 10.7
9 extrapontine myelinolysis 10.7
10 simpson-golabi-behmel syndrome 10.3 CNTNAP2 SLC6A3
11 adrenal gland pheochromocytoma 10.2 CHMP2B SLC6A3
12 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.1 GJB2 MITF
13 cerebritis 10.1
14 schizophrenia 10.1
15 propriospinal myoclonus 10.0 CHMP2B GRN
16 isolated focal cortical dysplasia type ic 10.0 CHMP2B GRN
17 mesenchymal chondrosarcoma 10.0 CHMP2B GRN
18 geniculate herpes zoster 10.0 CNTNAP2 GRN
19 melanoma, cutaneous malignant, 2 10.0 CHMP2B GRN
20 medulloblastoma 10.0
21 progressive bulbar palsy 9.9 CHMP2B GRN
22 social phobia 9.9
23 osteogenesis imperfecta, type ix 9.9 CNTNAP2 SLC6A3
24 atypical autism 9.9 CNTNAP2 SHANK3
25 nosophobia 9.9 CHMP2B GRN
26 brain stem infarction 9.9
27 perry syndrome 9.8 GRN SLC6A3
28 hydrocephalus 9.8
29 head injury 9.8
30 supranuclear palsy, progressive atypical 9.8 GRN SLC6A3
31 apraxia 9.8
32 cerebral artery occlusion 9.8
33 obstructive hydrocephalus 9.8
34 chronic conjunctivitis 9.8 SHANK3 SLC6A3
35 brain injury 9.7
36 goiter 9.7
37 astrocytoma 9.7
38 anterior cerebral artery infarction 9.7
39 hemangioblastoma 9.7
40 acute disseminated encephalomyelitis 9.7
41 dysphagia 9.7
42 encephalopathy 9.7
43 pervasive developmental disorder 9.7 GRN SLC6A3
44 sexual disorder 9.7 CNTNAP2 SHANK3 SLC6A3
45 parkinson disease 1 9.7 GRN SLC6A3
46 tendinopathy 9.7 CNTNAP2 GRN
47 lung cancer 9.6
48 creutzfeldt-jakob disease 9.6
49 traumatic brain injury 9.6
50 aphasia 9.6

Graphical network of the top 20 diseases related to Mutism:



Diseases related to Mutism

Symptoms & Phenotypes for Mutism

UMLS symptoms related to Mutism:


aphonia, fatigue, sleep disturbances, photophobia, personality changes, scanning speech, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Mutism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.55 CNTNAP2 GJB2 MITF SHANK3 SLC6A3
2 nervous system MP:0003631 9.5 SLC6A3 CHMP2B CNTNAP2 GJB2 GRN MITF
3 taste/olfaction MP:0005394 8.8 CNTNAP2 SHANK3 SLC6A3

Drugs & Therapeutics for Mutism

Drugs for Mutism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
2 Antidepressive Agents Phase 3
3 Antidepressive Agents, Second-Generation Phase 3
4 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
5 Cytochrome P-450 Enzyme Inhibitors Phase 3
6 Neurotransmitter Agents Phase 3
7 Neurotransmitter Uptake Inhibitors Phase 3
8 Psychotropic Drugs Phase 3
9
Serotonin Phase 3 50-67-9 5202
10 Serotonin Agents Phase 3
11 Serotonin Uptake Inhibitors Phase 3
12
Menthol Approved 2216-51-5 16666

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Treatment of Childhood Social Phobia Completed NCT00043537 Phase 3 Fluoxetine;Pill Placebo
2 Randomised Controlled Treatment Study of Selective Mutism Completed NCT01002196 Phase 2
3 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
4 Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
5 Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia. Completed NCT00170703 Phase 1
6 Posterior Fossa Mutism on Quality of Life Completed NCT02048176
7 Integrated Behavioral Therapy for Treating Children With Selective Mutism Completed NCT00458198
8 Web-Based CBT Protocol for Treatment of Selective Mutism Completed NCT02009839
9 What Treatment Works for Children With Selective Mutism? Completed NCT00554749
10 Cerebellar Mutism Syndrome Study Recruiting NCT02300766
11 Functional Imaging of Cerebellar Mutism Syndrome Recruiting NCT01733173
12 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069
13 Treating Refractory Schizophrenia With rTMS Recruiting NCT02242578
14 Treatment of Social Anxiety Disorder and Selective Mutism Active, not recruiting NCT02554929
15 DTI & Tractography in Pediatric Tumor Surgery Not yet recruiting NCT02810626

Search NIH Clinical Center for Mutism

Cochrane evidence based reviews: mutism

Genetic Tests for Mutism

Genetic tests related to Mutism:

id Genetic test Affiliating Genes
1 Mutism 29

Anatomical Context for Mutism

MalaCards organs/tissues related to Mutism:

39
Brain, Liver, Bone, Neutrophil, Thyroid, Bone Marrow, Lung

Publications for Mutism

Articles related to Mutism:

(show top 50) (show all 579)
id Title Authors Year
1
Sudden benzodiazepine-induced resolution of post-operative pediatric cerebellar mutism syndrome: a clinical-SPECT study. ( 28050719 )
2017
2
Brugada syndrome and calcium channel mutation in a patient with congenital deaf mutism. ( 28401855 )
2017
3
Akinetic mutism in a patient with mild traumatic brain injury: A diffusion tensor tractography study. ( 28406325 )
2017
4
Successful Treatment of a Child with Difficult-to-Treat Chronic Selective Mutism Using Pramipexole. ( 28398815 )
2017
5
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report. ( 28622210 )
2017
6
Akinetic mutism in a patient with acute infarcts in the bilateral substantia nigra. ( 28131224 )
2017
7
Analysis of surgical and MRI factors associated with cerebellar mutism. ( 28527006 )
2017
8
Apraxia of speech and cerebellar mutism syndrome: a case report. ( 28074148 )
2017
9
Ericksonian hypnotherapy for selective mutism: A single-case study. ( 28112698 )
2017
10
Switching to aripiprazole for the treatment of residual mutism resulted in distinct clinical courses in two catatonic schizophrenia cases. ( 28255444 )
2017
11
Remote Cerebellar Hemorrhage Presenting with Cerebellar Mutism after Spinal Surgery: An Unusual Case Report. ( 28490165 )
2017
12
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. ( 28447507 )
2017
13
Risk factors for development of postoperative cerebellar mutism syndrome in children after medulloblastoma surgery. ( 28498095 )
2017
14
Postoperative Pediatric Cerebellar Mutism After Posterior Fossa Surgery: A Case Report. ( 28118217 )
2017
15
Reply to "Post-surgical mutism and catatonia". ( 28391444 )
2017
16
Cerebellar mutism syndrome: cause and rehabilitation. ( 28118304 )
2017
17
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. ( 27977468 )
2017
18
Post-surgical cerebellar mutism and catatonia. ( 28397134 )
2017
19
Cerebellar mutism syndrome in children with brain tumours of the posterior fossa. ( 28637445 )
2017
20
Akinetic mutism and the story of David. ( 28150524 )
2017
21
The Complex Diagnostic Challenge in Children With Non-Central Nervous System Cancer and Cerebellar Mutism. ( 28497710 )
2017
22
Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. ( 27942473 )
2016
23
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. ( 26825206 )
2016
24
Acquired Mutism and Hypertonia in a Toddler. ( 27364777 )
2016
25
Selective mutism. ( 26709680 )
2016
26
Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation. ( 27069898 )
2016
27
Identifying Treatment Response of Sertraline in a Teenager with Selective Mutism using Electrophysiological Neuroimaging. ( 27468379 )
2016
28
Social Communication Anxiety Treatment (S-CAT) for children and families with selective mutism: A pilot study. ( 26940121 )
2016
29
Augmentative and Alternative Communication (AAC) for a patient with a nonfluent/ agrammatic variant of PPA in the mutism stage. ( 27007540 )
2016
30
Selective Mutism: The Fraternal Twin of Childhood Social Phobia. ( 27089281 )
2016
31
A Case of Mutism in Noncatatonic Schizophrenia Responding to Small Dose of Fluvoxamine Addition to Clozapine. ( 27508430 )
2016
32
A case of mutism on emergence from general anesthesia. ( 26872966 )
2016
33
Selective mutism and temperament: the silence and behavioral inhibition to the unfamiliar. ( 26970743 )
2016
34
Pediatric selective mutism therapy: a randomized controlled trial. ( 27830922 )
2016
35
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. ( 27418987 )
2016
36
Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results. ( 27142103 )
2016
37
Akinetic mutism revealing an ischemic stroke. ( 27955795 )
2016
38
126a88Anatomy of Cerebellar Mutism: Reduced Fractional Anisotropy in the Superior Cerebellar Peduncle. ( 27399405 )
2016
39
Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease. ( 27646053 )
2016
40
Anxiety and oppositional behavior profiles among youth with selective mutism. ( 26625009 )
2016
41
Children Who are Anxious in Silence: A Review on Selective Mutism, the New Anxiety Disorder in DSM-5. ( 25724675 )
2015
42
Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. ( 26145481 )
2015
43
An auditory-neuroscience perspective on the development of selective mutism. ( 25625220 )
2015
44
Children of Few Words: Relations Among Selective Mutism, Behavioral Inhibition, and (Social) Anxiety Symptoms in 3- to 6-Year-Olds. ( 25842046 )
2015
45
Ties of silence - Family lived experience of selective mutism in identical twins. ( 26092264 )
2015
46
A Selective Mutism Arising from First Language Attrition, Successfully Treated with Paroxetine-CBT Combination Treatment. ( 26508972 )
2015
47
The use of medication in selective mutism: a systematic review. ( 26560144 )
2015
48
Mutism in non-catatonic schizophrenia: Psychotic symptom and adaptive behavioral strategy. ( 26144881 )
2015
49
Absence of Nails, Deaf-mutism, Seizures, and Intellectual Disability: A Case Report. ( 26023614 )
2015
50
Cerebellar mutism. ( 26351234 )
2015

Variations for Mutism

ClinVar genetic disease variations for Mutism:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SHANK3 NM_033517.1(SHANK3): c.3637dupC (p.His1213Profs) duplication Pathogenic GRCh37 Chromosome 22, 51159898: 51159898

Expression for Mutism

Search GEO for disease gene expression data for Mutism.

Pathways for Mutism

GO Terms for Mutism

Biological processes related to Mutism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 9.4 SHANK3 SLC6A3
2 learning GO:0007612 9.37 CNTNAP2 SHANK3
3 social behavior GO:0035176 9.32 CNTNAP2 SHANK3
4 cognition GO:0050890 9.26 CHMP2B LINS1
5 adult behavior GO:0030534 9.16 CNTNAP2 SHANK3
6 vocalization behavior GO:0071625 8.96 CNTNAP2 SHANK3
7 vocal learning GO:0042297 8.62 CNTNAP2 SHANK3

Sources for Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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