MCID: MTS001
MIFTS: 46

Mutism malady

Summaries for Mutism

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Muteness or mutism (from Latin mutus, meaning \"silent\") is an inability to speak caused by a speech... more...

MalaCards: Mutism is related to akinetic mutism and schizophrenia. An important gene associated with Mutism is GJB2 (gap junction protein, beta 2, 26kDa). The compounds methylphenidate and plp (139-151) have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related mouse phenotypes are reproductive system and nervous system.

Disease Ontology:8 A speech disorder that involves a complete inability to speak.

Aliases & Classifications for Mutism

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

mutism 8 10 60


External Ids:

Disease Ontology8 DOID:4189
SNOMED-CT56 88052002, 267771000
MeSH34 D009155

Related Diseases for Mutism

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17GeneCards, 18GeneDecks
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Diseases related to Mutism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1akinetic mutism31.1ACAA2, PRNP, MBP, PNMA2, TXNDC9
2schizophrenia30.3SLC6A3, PICK1, MBP, DRD5
3meningioma29.6GJB2
4pendred syndrome29.6GJB2
5encephalitis29.6MBP, CNTNAP2, PNMA2
6cerebritis10.3
7elective mutism10.3
8cerebellar medulloblastoma10.2
9medulloblastoma10.2
10social phobia10.2
11brain stem infarction10.1
12anxiety disorder10.1
13hydrocephalus10.1
14cerebral artery occlusion10.0
15obstructive hydrocephalus10.0
16apraxia10.0
17goiter10.0
18hemangioblastoma10.0
19creutzfeldt-jakob syndrome10.0PRNP
20fatal familial insomnia10.0PRNP
21parkinson's disease10.0SLC6A3
22pathological gambling10.0SLC6A3
23prion disease10.0TXNDC9, PNMA2
24bipolar disorder10.0DRD5, SLC6A3
25substance dependence10.0DRD5, SLC6A3
26migraine10.0SLC6A3, DRD5
27vascular dementia10.0PRNP, MBP
28progressive supranuclear palsy10.0SLC6A3, PRNP
29multiple system atrophy10.0MBP, PRNP, SLC6A3
30gilles de la tourette syndrome10.0SLC6A3, CNTNAP2
31lewy body dementia10.0PRNP, SLC6A3
32hyperphenylalaninemia10.0QDPR
33breast cancer10.0GJB2, MBP, FANCL
34x-linked ichthyosis9.9
35choroiditis9.9
36basilar artery occlusion9.9
37anterior cerebral artery infarction9.9
38acute disseminated encephalomyelitis9.9
39adult syndrome9.9
40fragile x syndrome9.9
41aphasia9.9
42astrocytoma9.9
43cervicitis9.9
44encephalomyelitis9.9
45galactosemia9.9
46lung cancer9.9
47specific phobia9.9
48albinism9.9
49spastic paraplegia 19.9
50sialidosis type i9.9

Graphical network of the top 20 diseases related to Mutism:



Diseases related to mutism

Clinical Features for Mutism

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Drugs & Therapeutics for Mutism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mutism

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Anatomical Context for Mutism

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32MalaCards
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MalaCards organs/tissues related to Mutism:

32
Brain, Liver, Bone, Bone marrow, Lung, Heart, Eye, Thyroid, Skin, Testes, Tongue, Appendix

Animal Models for Mutism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mutism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.6FANCL, PICK1, PRNP, MITF, GJB2, SLC6A3
2MP:00036317.7SLC6A3, MBP, DRD5, PICK1, ATP1A3, PRNP

Publications for Mutism

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50PubMed
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Articles related to Mutism:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Telephone effect in akinetic mutism from traumatic brain injury. (23932533)
2013
2
Abnormalities in auditory efferent activities in children with selective mutism. (24107432)
2013
3
Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate. (22672948)
2012
4
Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report. (22476660)
2012
5
Reversible acute encephalopathy with mutism, induced by calcineurin inhibitors after renal transplantation. (22252846)
2012
6
Heralding cerebellar mutism: evidence for pre-surgical language impairment as primary risk factor in posterior fossa surgery. (21476131)
2011
7
Mutism and amnesia following high-voltage electrical injury: psychogenic symptomatology triggered by organic dysfunction? (21952143)
2011
8
Mutism and persistent dysarthria due to tacrolimus-based immunosuppression following allogeneic liver transplantation. (20535006)
2011
9
Mutism as the presenting symptom: three case reports and selective review of literature. (21799563)
2010
10
Brainstem compression: a predictor of postoperative cerebellar mutism. (19082829)
2009
11
Increased left prefrontal activation during staring/mutism episodes in a patient with resistant catatonic schizophrenia: a near infrared spectroscopy study. (18327023)
2008
12
Treatment of akinetic mutism with intramuscular olanzapine: a case series. (18305290)
2008
13
'More than 100 years of silence', elective mutism: a review of the literature. (18357427)
2008
14
Examination of a social problem-solving intervention to treat selective mutism. (18285505)
2008
15
Group therapy for selective mutism - a parents' and children's treatment group. (18304518)
2008
16
Adult cerebellar mutism and cognitive-affective syndrome caused by hemangioblastoma. (17426999)
2007
17
Transient cerebellar mutism in childhood. (17384951)
2007
18
When silence is not golden: an integrated approach to selective mutism. (16155858)
2005
19
Mutism as a complication of total intravenous anesthesia by propofol. (14633577)
2003
20
Insightful contribution to empirical analyses of selective mutism (SM). (13680405)
2003
21
Mutism after posterior fossa tumour resection in children: incomplete recovery on long-term follow-up. (12944697)
2003
22
Web-based CBT for selective mutism. (11841064)
2002
23
Mutism after surgical removal of a cerebellar tumor: two case reports. (11255729)
2001
24
Bilateral crossed cerebello-cerebral diaschisis and mutism after surgery for cerebellar medulloblastoma. (11448076)
2001
25
Transient mutism after brain stem infarction. (10809658)
2000
26
A case of mutism subsequent to cocaine abuse. (10435258)
1999
27
Akinetic mutism after fourth ventricle choroid plexus papilloma: treatment with a dopamine agonist. (10029425)
1999
28
Case study: audio feedforward treatment of selective mutism. (9444898)
1998
29
Acute confusion and mutism as a presentation of thalamic strokes secondary to deep cerebral venous thrombosis. (9660519)
1998
30
Akinetic mutism and magnetic resonance imaging in obstructive hydrocephalus. Case illustration. (9420094)
1998
31
Selective mutism among second-graders in elementary school. (9563810)
1998
32
Postoperative mutism after the clipping of a distal anterior cerebral artery aneurysm. A case report. (9297726)
1997
33
Cerebellar mutism: report of two unusual cases and review of the literature. (9213058)
1997
34
Systematic assessment of 50 children with selective mutism. (9136500)
1997
35
Prolonged akinetic mutism due to multiple sclerosis. (7711499)
1995
36
Akinetic mutism caused by bilateral anterior cerebral tuberculous obliterative arteritis. (2345604)
1990
37
Methylphenidate in amytal-resistant mutism. (2735213)
1989
38
Labeling and functional language in a case of psychological mutism. (3667955)
1987
39
Mutism, malingering, and competency to stand trial. (3676530)
1987
40
Elective mutism: a case study of a disorder of childhood. (3316671)
1987
41
A comparison of elective mutism and emotional disorders in children. (3978335)
1985
42
Elective mutism associated with selective inactivity. (4008679)
1985
43
Traumatic mutism and the subsequent reorganization of speech functions. (7329526)
1981
44
Elective mutism in children. (291592)
1979
45
Cardio-respiratory arrest associated with cerebral anoxia and vigilant akinetic mutism. Dynamic clinical and polygraphic study of a case with electroclinical recovery. (1188271)
1975
46
Acupuncture therapeutics for deaf-mutism. From the appendix of clinical manual of treatments of common recurrent diseases employing Chinese traditional medicine. (4774369)
1973
47
Delayed akinetic mutism after subarachnoid haemorrhage. (4666109)
1972
48
Syndrome of profound apathy (akinetic mutism) secondary to thalamic metastasis of unrecognized lung cancer. (4333729)
1972
49
Psychologic approach to psychosexual misidentity with elective mutism: sex reassignment in two cases of hyperadrenocortical hermaphroditism. (4869854)
1968
50
Syndrome of akinetic mutism associated with obstructive hydrocephalus. (5296101)
1966

Genetic Variations for Mutism

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Expression for genes affiliated with Mutism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mutism

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Pathways for genes affiliated with Mutism

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Compounds for genes affiliated with Mutism

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Mutism according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1methylphenidate44 49 1112.1SLC6A3, DRD5
2plp (139-151)5910.1PRNP, MBP
3c3bot (154-182)5910.1MBP, PRNP
4ono 25065910.1MBP, PRNP
5nogo-66 (1-40)5910.1MBP, PRNP
6mog (35-55)5910.1MBP, PRNP
7hemocyanin449.9MBP, PRNP
8levodopa44 1110.9DRD5, QDPR, SLC6A3
9pramipexole44 49 28 1112.7SLC6A3, DRD5
10norepinephrine44 11 2411.5SLC6A3, QDPR, DRD5, MBP
11paraffin449.3GJB2, MITF, PRNP, MBP
12glutamate449.0PICK1, PRNP, MITF, SLC6A3, MBP
13lipid448.7MBP, PICK1, PRNP, QDPR, MITF, GJB2

GO Terms for genes affiliated with Mutism

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16Gene Ontology
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Cellular components related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.6SLC6A3, CNTNAP2, ATP1A3

Biological processes related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transportGO:0158449.9SLC6A3, PICK1
2response to cocaineGO:0422209.7SLC6A3, DRD5
3synaptic transmissionGO:0072689.4SLC6A3, PICK1, DRD5, MBP

Molecular functions related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.0SLC6A3, DRD5

Products for genes affiliated with Mutism

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Sources for Mutism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet