Aliases & Classifications for Mutism

About this section

Aliases & Descriptions for Mutism:

Name: Mutism 11 13 25 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:4189
SNOMED-CT60 267771000, 88052002
MeSH37 D009155

Summaries for Mutism

About this section
Disease Ontology:11 A speech disorder that involves a complete inability to speak.

MalaCards based summary: Mutism is related to elective mutism and akinetic mutism, and has symptoms including aphonia, drooling and fatigue. An important gene associated with Mutism is CNTNAP2 (Contactin Associated Protein-Like 2). Affiliated tissues include brain, liver and bone, and related mouse phenotypes are pigmentation and integument.

Related Diseases for Mutism

About this section

Graphical network of the top 20 diseases related to Mutism:



Diseases related to mutism

Symptoms for Mutism

About this section

UMLS symptoms related to Mutism:


aphonia, drooling, fatigue, sleep disturbances, photophobia, neologism, aprosodia, personality change, scanning speech, speech and language abnormalities, restlessness, pseudobulbar behavioral symptoms

Drugs & Therapeutics for Mutism

About this section

Drugs for Mutism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FluoxetinePhase 322954910-89-33386
Synonyms:
(+) or (-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+) or (-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-P-tolyl)oxy)propylamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+/-)-Fluoxetine
(+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine
(+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]
(+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine
3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
52341-67-0
54910-89-3
57226-07-0
59333-67-4 (hydrochloride)
AB00053774
AC-14564
AC1L1FTH
AKOS003663021
Adofen
Animex-On
BPBio1_000354
BPBio1_000509
BRD-A31159102-001-01-9
BRD-A31159102-003-05-6
BSPBio_000461
BSPBio_003375
Bio-0787
Biomol-NT_000152
C17H18F3NO
CHEBI:5118
CHEMBL41
CID3386
D00326
DB00472
Deprex
DivK1c_006819
Eufor
Floxetine
Fluctin
Fluoxeren
Fluoxetin
Fluoxetina
Fluoxetina [INN-Spanish]
Fluoxetina [Spanish]
Fluoxetine (TN)
Fluoxetine (USAN/INN)
Fluoxetine Hcl
Fluoxetine Hydrochloride
Fluoxetine [USAN:INN:BAN]
Fluoxetinum
 
Fluoxetinum [INN-Latin]
Fluoxétine
Fluval
Fontex
Foxetin
HMS2090H14
KBio1_001763
KBio2_002159
KBio2_004727
KBio2_007295
KBio3_002595
KBioGR_001166
KBioSS_002159
L000931
LS-31040
Lilly-110140
Lopac0_000558
Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine
MolPort-001-683-482
N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine
NCGC00015428-10
NCGC00024879-03
NCGC00024879-04
NSC283480
Portal
Prestwick0_000511
Prestwick1_000511
Prestwick2_000511
Prestwick3_000511
Prozac
Prozac Weekly
Pulvules
Reconcile
Reneuron
SPBio_001815
SPBio_002382
STK734483
Sarafem
SpecPlus_000723
Spectrum2_001658
Spectrum3_001648
Spectrum4_000613
Spectrum5_001518
Spectrum_001679
TL8003595
UNII-01K63SUP8D
dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
fluoxetine
fluoxetine (Prozac)
nchembio.534-comp2
2
SerotoninPhase 3351050-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
3
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Treatment of Childhood Social PhobiaCompletedNCT00043537Phase 3
2Randomised Controlled Treatment Study of Selective MutismCompletedNCT01002196Phase 2
3Brief Behavioral Treatment for Anxiety in Young ChildrenCompletedNCT02051192Phase 1, Phase 2
4Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and AnxietyCompletedNCT01187784Phase 1
5Posterior Fossa Mutism on Quality of LifeCompletedNCT02048176
6Integrated Behavioral Therapy for Treating Children With Selective MutismCompletedNCT00458198
7Web-Based CBT Protocol for Treatment of Selective MutismCompletedNCT02009839
8What Treatment Works for Children With Selective Mutism?CompletedNCT00554749
9Treatment of Social Anxiety Disorder and Selective MutismRecruitingNCT02554929
10Cerebellar Mutism Syndrome StudyRecruitingNCT02300766
11Vagal Nerve Stimulation in Coma PatientsRecruitingNCT02591069
12Functional Imaging of Cerebellar Mutism SyndromeRecruitingNCT01733173
13Treating Refractory Schizophrenia With rTMSRecruitingNCT02242578
14DTI & Tractography in Pediatric Tumor SurgeryNot yet recruitingNCT02810626

Search NIH Clinical Center for Mutism


Cochrane evidence based reviews: mutism

Genetic Tests for Mutism

About this section

Genetic tests related to Mutism:

id Genetic test Affiliating Genes
1 Mutism25

Anatomical Context for Mutism

About this section

MalaCards organs/tissues related to Mutism:

34
Brain, Liver, Bone, Neutrophil, Thyroid, Bone marrow, Lung

Animal Models for Mutism or affiliated genes

About this section

MGI Mouse Phenotypes related to Mutism:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9FANCL, GRN, MITF
2MP:00107718.3CNTNAP2, FANCL, GJB2, MITF, SLC6A3
3MP:00053897.7FANCL, GJB2, GRN, MITF, SLC6A3
4MP:00036317.3CHMP2B, CNTNAP2, GJB2, GRN, MITF, SLC6A3
5MP:00053847.2CNTNAP2, FANCL, GJB2, GRN, MITF, SLC6A3

Publications for Mutism

About this section

Articles related to Mutism:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Absence of Nails, Deaf-mutism, Seizures, and Intellectual Disability: A Case Report. (26023614)
2015
2
A Selective Mutism Arising from First Language Attrition, Successfully Treated with Paroxetine-CBT Combination Treatment. (26508972)
2015
3
Cerebellar Mutism Caused by Primary Varicella Infection in an Immunocompetent Child. (23446802)
2013
4
Cerebellar mutism. (23398780)
2013
5
Selective mutism: a team approach to assessment and treatment in the school setting. (21970860)
2012
6
Vegetative state, minimally conscious state, akinetic mutism and Parkinsonism as a continuum of recovery from disorders of consciousness: an exploratory and preliminary study. (21693084)
2011
7
Cerebellar mutism in pediatric acute disseminated encephalomyelitis. (20837316)
2010
8
Persistent akinetic mutism after bilateral paramedian thalamic infarction. (19776325)
2009
9
Treatment of akinetic mutism with intramuscular olanzapine: a case series. (18305290)
2008
10
Selective mutism and the anxiety spectrum--a long-term case report. (18592113)
2008
11
Hysterical mutism associated with a diagnosis of lung cancer. (17878510)
2007
12
Reduced auditory processing capacity during vocalization in children with Selective Mutism. (16616723)
2007
13
Akinetic mutism caused by nicotine withdrawal. (19455735)
2007
14
Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report. (16509510)
2006
15
Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison's disease. (16682841)
2006
16
A long-term outcome study of selective mutism in childhood. (16790010)
2006
17
Reversible diffusion MRI abnormalities and transient mutism after liver transplantation. (15642940)
2005
18
Mixed neuronal-glial tumor of the fourth ventricle and successful treatment of postoperative mutism with bromocriptine: case report. (15808729)
2005
19
Transient cerebellar mutism in the course of acute cerebellitis. (14738957)
2004
20
Prevalence and description of selective mutism in immigrant and native families: a controlled study. (14627880)
2003
21
Nonsurgical cerebellar mutism (anarthria) in two children. (12657422)
2003
22
Selective mutism and obsessive compulsive disorders associated with zonisamide. (12237077)
2002
23
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. (11983799)
2002
24
Selective mutism: how a successful speech and language assessment really is possible. (11340767)
2001
25
Elective mutism: effect of dental treatment with N2/O2-inhalation sedation: review and report of case. (10360207)
1999
26
Tumour type and size are high risk factors for the syndrome of "cerebellar" mutism and subsequent dysarthria. (10567492)
1999
27
Case study: audio feedforward treatment of selective mutism. (9444898)
1998
28
Elective mutism: an analysis of 100 cases. (8935207)
1996
29
Cerebellar mutism following posterior fossa tumour surgery. (8861318)
1996
30
Akinetic mutism with bithalamic infarction. Neurophysiological correlates. (8836973)
1996
31
The syndrome of 'cerebellar' mutism and subsequent dysarthria. (7969956)
1994
32
Transient mutism after posterior fossa surgery. (7923241)
1994
33
Silent at school--elective mutism and abuse. (8048829)
1994
34
A parent comments on elective mutism. (8496136)
1993
35
Elective mutism and mental retardation. (8340310)
1993
36
Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings. (1573414)
1992
37
Biopercular lesions and acquired mutism in a young patient. (1933083)
1991
38
Transient cerebellar mutism after posterior cranial fossa surgery in an adult. Case report and review of the literature. (1665764)
1991
39
Cerebellar mutism after posterior fossa surgery. (2133406)
1990-1991
40
Benzodiazepines for catatonic symptoms, stupor, and mutism. (2907648)
1988
41
Mutism, malingering, and competency to stand trial. (3676530)
1987
42
Akinetic mutism in a bone marrow transplant recipient following total-body irradiation and amphotericin B chemoprophylaxis. A positron emission tomographic and neuropathologic study. (3548667)
1987
43
Another differential to mutism. (3752970)
1986
44
Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism. (3080815)
1986
45
Mutism following left hemisphere infarction. (6210346)
1984
46
Articulatory recovery after traumatic mutism. (6654280)
1983
47
Mutism and hyperthermia in a patient treated with neuroleptics. (4744098)
1973
48
Akinetic mutism with recovery after repeated carbon monoxide poisoning. (5148768)
1971
49
DIAGNOSIS AND TREATMENT OF ELECTIVE MUTISM IN CHILDREN. (14281154)
1964
50
Acute intestinal obstruction with volvulus in akinetic mutism. A report of a case. (13978430)
1963

Variations for Mutism

About this section

Expression for genes affiliated with Mutism

About this section
Search GEO for disease gene expression data for Mutism.

Pathways for genes affiliated with Mutism

About this section

GO Terms for genes affiliated with Mutism

About this section

Biological processes related to Mutism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to estradiolGO:00323559.2GJB2, GRN

Sources for Mutism

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet