Aliases & Classifications for Mutism

MalaCards integrated aliases for Mutism:

Name: Mutism 12 28 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4189
MeSH 41 D009155
SNOMED-CT 64 267771000 88052002
UMLS 69 C0026884

Summaries for Mutism

Disease Ontology : 12 A speech disorder that involves a complete inability to speak.

MalaCards based summary : Mutism is related to aphasia and speech disorder, and has symptoms including pseudobulbar behavioral symptoms, restlessness and scanning speech. An important gene associated with Mutism is SHANK3 (SH3 And Multiple Ankyrin Repeat Domains 3). The drugs Fluoxetine and Serotonin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are integument and nervous system

Related Diseases for Mutism

Diseases related to Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 aphasia 29.4 CHMP2B GRN
2 speech disorder 29.3 CNTNAP2 GRN
3 elective mutism 12.5
4 akinetic mutism 12.5
5 frontotemporal dementia 10.9
6 frontotemporal dementia, chromosome 3-linked 10.9
7 syndromic x-linked intellectual disability 12 10.9
8 central pontine myelinolysis 10.9
9 short stature deafness neutrophil dysfunction 10.9
10 extrapontine myelinolysis 10.9
11 branchiootic syndrome 1 10.4
12 anxiety 10.2
13 cerebritis 10.2
14 stuttering 10.2 CNTNAP2 SLC6A3
15 schizophrenia 10.2
16 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 10.1 GJB2 MITF
17 synucleinopathy 10.1 CHMP2B SLC6A3
18 pendred syndrome 10.1 GJB2 MITF
19 medulloblastoma 10.1
20 social phobia 10.0
21 progressive non-fluent aphasia 10.0 CHMP2B GRN
22 hydrocephalus 10.0
23 brain stem infarction 10.0
24 behavioral variant of frontotemporal dementia 10.0 CHMP2B GRN
25 nominal aphasia 9.9 CHMP2B GRN
26 autism 9.9
27 head injury 9.9
28 pervasive developmental disorder 9.9 CNTNAP2 SHANK3
29 basal ganglia disease 9.9 CHMP2B GRN
30 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.9 CHMP2B GRN
31 gilles de la tourette syndrome 9.9 CNTNAP2 SLC6A3
32 apraxia 9.9
33 cerebral artery occlusion 9.9
34 obstructive hydrocephalus 9.9
35 perry syndrome 9.9 GRN SLC6A3
36 brain injury 9.8
37 goiter 9.8
38 astrocytoma 9.8
39 anterior cerebral artery infarction 9.8
40 hemangioblastoma 9.8
41 acute disseminated encephalomyelitis 9.8
42 dysphagia 9.8
43 encephalopathy 9.8
44 supranuclear palsy, progressive, 1 9.8 GRN SLC6A3
45 specific developmental disorder 9.8 GRN SLC6A3
46 autism spectrum disorder 9.7 CNTNAP2 SHANK3 SLC6A3
47 blood group, i system 9.7
48 creutzfeldt-jakob disease 9.7
49 tuberous sclerosis 1 9.7
50 lung cancer 9.7

Graphical network of the top 20 diseases related to Mutism:



Diseases related to Mutism

Symptoms & Phenotypes for Mutism

UMLS symptoms related to Mutism:


pseudobulbar behavioral symptoms, restlessness, scanning speech, personality changes, photophobia, sleep disturbances, aphonia

MGI Mouse Phenotypes related to Mutism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.55 CNTNAP2 GJB2 MITF SHANK3 SLC6A3
2 nervous system MP:0003631 9.5 CHMP2B CNTNAP2 GJB2 GRN MITF SHANK3
3 taste/olfaction MP:0005394 8.8 CNTNAP2 SHANK3 SLC6A3

Drugs & Therapeutics for Mutism

Drugs for Mutism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
2
Serotonin Phase 3 50-67-9 5202
3 Serotonin Agents Phase 3
4 Serotonin Uptake Inhibitors Phase 3
5 Neurotransmitter Agents Phase 3
6 Neurotransmitter Uptake Inhibitors Phase 3
7 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
8 Cytochrome P-450 Enzyme Inhibitors Phase 3
9 Antidepressive Agents Phase 3
10 Antidepressive Agents, Second-Generation Phase 3
11 Psychotropic Drugs Phase 3
12
Menthol Approved 2216-51-5 16666

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Treatment of Childhood Social Phobia Completed NCT00043537 Phase 3 Fluoxetine;Pill Placebo
2 Randomised Controlled Treatment Study of Selective Mutism Completed NCT01002196 Phase 2
3 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
4 Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
5 Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia. Completed NCT00170703 Phase 1
6 Posterior Fossa Mutism on Quality of Life Completed NCT02048176
7 Web-Based CBT Protocol for Treatment of Selective Mutism Completed NCT02009839
8 Integrated Behavioral Therapy for Treating Children With Selective Mutism Completed NCT00458198
9 What Treatment Works for Children With Selective Mutism? Completed NCT00554749
10 Cerebellar Mutism Syndrome Study Recruiting NCT02300766
11 Functional Imaging of Cerebellar Mutism Syndrome Recruiting NCT01733173
12 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069
13 Treating Refractory Schizophrenia With rTMS Recruiting NCT02242578
14 Treatment of Social Anxiety Disorder and Selective Mutism Active, not recruiting NCT02554929
15 DTI & Tractography in Pediatric Tumor Surgery Not yet recruiting NCT02810626

Search NIH Clinical Center for Mutism

Cochrane evidence based reviews: mutism

Genetic Tests for Mutism

Genetic tests related to Mutism:

# Genetic test Affiliating Genes
1 Mutism 28

Anatomical Context for Mutism

MalaCards organs/tissues related to Mutism:

38
Brain, Liver, Bone, Neutrophil, Thyroid, Bone Marrow, Lung

Publications for Mutism

Articles related to Mutism:

(show top 50) (show all 592)
# Title Authors Year
1
Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome. ( 29433337 )
2018
2
Akinetic mutism following prefrontal injury by an electrical grinder a case report: A diffusion tensor tractography study. ( 29419694 )
2018
3
Unable to Speak: Selective Mutism in Youth. ( 29385228 )
2018
4
Treatment of selective mutism based on cognitive behavioural therapy, psychopharmacology and combination therapy - a systematic review. ( 29447060 )
2018
5
Non-surgical transient cerebellar mutism-case report and systematic review. ( 29067507 )
2018
6
Cerebellar Mutism Syndrome and Other Complications After Surgery in the Posterior Fossa in Adults: A Prospective Study. ( 29180084 )
2018
7
Treatment of selective mutism: a 5-year follow-up study. ( 29357099 )
2018
8
An Examination of Fluoxetine for the Treatment of Selective Mutism Using a Nonconcurrent Multiple-Baseline Single-Case Design Across 5 Cases. ( 29320378 )
2018
9
Post-surgical cerebellar mutism and catatonia. ( 28397134 )
2017
10
Successful Treatment of a Child with Difficult-to-Treat Chronic Selective Mutism Using Pramipexole. ( 28398815 )
2017
11
Children's and parent's psychological profiles in selective mutism and generalized anxiety disorder: a clinical study. ( 29081005 )
2017
12
Neuroanatomical Mechanism of Cerebellar Mutism After Stroke. ( 29354585 )
2017
13
Risk factors for development of postoperative cerebellar mutism syndrome in children after medulloblastoma surgery. ( 28498095 )
2017
14
Switching to aripiprazole for the treatment of residual mutism resulted in distinct clinical courses in two catatonic schizophrenia cases. ( 28255444 )
2017
15
The Complex Diagnostic Challenge in Children With Non-Central Nervous System Cancer and Cerebellar Mutism. ( 28497710 )
2017
16
Sudden benzodiazepine-induced resolution of post-operative pediatric cerebellar mutism syndrome: a clinical-SPECT study. ( 28050719 )
2017
17
Apraxia of speech and cerebellar mutism syndrome: a case report. ( 28074148 )
2017
18
Ericksonian hypnotherapy for selective mutism: A single-case study. ( 28112698 )
2017
19
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. ( 28447507 )
2017
20
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report. ( 28622210 )
2017
21
Reply to "Post-surgical mutism and catatonia". ( 28391444 )
2017
22
Cerebellar mutism syndrome in children with brain tumours of the posterior fossa. ( 28637445 )
2017
23
Recovery of akinetic mutism and injured prefronto-caudate tract following shunt operation for hydrocephalus and rehabilitation: A case report. ( 29390310 )
2017
24
Akinetic mutism in a patient with acute infarcts in the bilateral substantia nigra. ( 28131224 )
2017
25
Analysis of surgical and MRI factors associated with cerebellar mutism. ( 28527006 )
2017
26
The Electroencephalogram Speaks for the Patient: Identification and Treatment of Akinetic Mutism With Comorbid Delirium. ( 29249557 )
2017
27
Akinetic mutism and the story of David. ( 28150524 )
2017
28
Postoperative Pediatric Cerebellar Mutism After Posterior Fossa Surgery: A Case Report. ( 28118217 )
2017
29
Latent Class Symptom Profiles of Selective Mutism: Identification and Linkage to Temperamental and Social Constructs. ( 29164351 )
2017
30
Akinetic mutism in a patient with mild traumatic brain injury: A diffusion tensor tractography study. ( 28406325 )
2017
31
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. ( 27977468 )
2017
32
Brugada syndrome and calcium channel mutation in a patient with congenital deaf mutism. ( 28401855 )
2017
33
Remote Cerebellar Hemorrhage Presenting with Cerebellar Mutism after Spinal Surgery: An Unusual Case Report. ( 28490165 )
2017
34
Cerebellar mutism syndrome: cause and rehabilitation. ( 28118304 )
2017
35
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. ( 26825206 )
2016
36
Social Communication Anxiety Treatment (S-CAT) for children and families with selective mutism: A pilot study. ( 26940121 )
2016
37
Augmentative and Alternative Communication (AAC) for a patient with a nonfluent/ agrammatic variant of PPA in the mutism stage. ( 27007540 )
2016
38
Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. ( 27942473 )
2016
39
Identifying Treatment Response of Sertraline in a Teenager with Selective Mutism using Electrophysiological Neuroimaging. ( 27468379 )
2016
40
Akinetic mutism revealing an ischemic stroke. ( 27955795 )
2016
41
Acquired Mutism and Hypertonia in a Toddler. ( 27364777 )
2016
42
Selective mutism and temperament: the silence and behavioral inhibition to the unfamiliar. ( 26970743 )
2016
43
126a88Anatomy of Cerebellar Mutism: Reduced Fractional Anisotropy in the Superior Cerebellar Peduncle. ( 27399405 )
2016
44
Anxiety and oppositional behavior profiles among youth with selective mutism. ( 26625009 )
2016
45
A case of mutism on emergence from general anesthesia. ( 26872966 )
2016
46
Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results. ( 27142103 )
2016
47
Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease. ( 27646053 )
2016
48
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. ( 27418987 )
2016
49
Selective mutism. ( 26709680 )
2016
50
A Case of Mutism in Noncatatonic Schizophrenia Responding to Small Dose of Fluvoxamine Addition to Clozapine. ( 27508430 )
2016

Variations for Mutism

ClinVar genetic disease variations for Mutism:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SHANK3 NM_033517.1(SHANK3): c.3637dupC (p.His1213Profs) duplication Pathogenic GRCh37 Chromosome 22, 51159898: 51159898

Expression for Mutism

Search GEO for disease gene expression data for Mutism.

Pathways for Mutism

GO Terms for Mutism

Biological processes related to Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 locomotory behavior GO:0007626 9.37 SHANK3 SLC6A3
2 learning GO:0007612 9.32 CNTNAP2 SHANK3
3 social behavior GO:0035176 9.26 CNTNAP2 SHANK3
4 adult behavior GO:0030534 9.16 CNTNAP2 SHANK3
5 vocalization behavior GO:0071625 8.96 CNTNAP2 SHANK3
6 vocal learning GO:0042297 8.62 CNTNAP2 SHANK3

Sources for Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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