MCID: MTS001
MIFTS: 46

Mutism malady

Summaries for Mutism

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Muteness or mutism (from Latin mutus, meaning \"silent\") is an inability to speak caused by a speech... more...

MalaCards: Mutism is related to akinetic mutism and schizophrenia. An important gene associated with Mutism is GJB2 (gap junction protein, beta 2, 26kDa). The compounds methylphenidate and plp (139-151) have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related mouse phenotypes are reproductive system and nervous system.

Disease Ontology:8 A speech disorder that involves a complete inability to speak.

Aliases & Classifications for Mutism

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

mutism 8 10 60


External Ids:

Disease Ontology8 DOID:4189
SNOMED-CT56 88052002, 267771000
MeSH34 D009155

Related Diseases for Mutism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mutism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1akinetic mutism31.1ACAA2, PRNP, MBP, PNMA2, TXNDC9
2schizophrenia30.3SLC6A3, PICK1, MBP, DRD5
3meningioma29.6GJB2
4pendred syndrome29.6GJB2
5encephalitis29.6MBP, CNTNAP2, PNMA2
6cerebritis10.3
7elective mutism10.3
8cerebellar medulloblastoma10.2
9medulloblastoma10.2
10social phobia10.2
11brain stem infarction10.1
12anxiety disorder10.1
13hydrocephalus10.1
14cerebral artery occlusion10.0
15obstructive hydrocephalus10.0
16apraxia10.0
17goiter10.0
18hemangioblastoma10.0
19creutzfeldt-jakob syndrome10.0PRNP
20fatal familial insomnia10.0PRNP
21parkinson's disease10.0SLC6A3
22pathological gambling10.0SLC6A3
23prion disease10.0TXNDC9, PNMA2
24bipolar disorder10.0DRD5, SLC6A3
25substance dependence10.0DRD5, SLC6A3
26migraine10.0SLC6A3, DRD5
27vascular dementia10.0PRNP, MBP
28progressive supranuclear palsy10.0SLC6A3, PRNP
29multiple system atrophy10.0MBP, PRNP, SLC6A3
30gilles de la tourette syndrome10.0SLC6A3, CNTNAP2
31lewy body dementia10.0PRNP, SLC6A3
32hyperphenylalaninemia10.0QDPR
33breast cancer10.0GJB2, MBP, FANCL
34x-linked ichthyosis9.9
35choroiditis9.9
36basilar artery occlusion9.9
37anterior cerebral artery infarction9.9
38acute disseminated encephalomyelitis9.9
39adult syndrome9.9
40fragile x syndrome9.9
41aphasia9.9
42astrocytoma9.9
43cervicitis9.9
44encephalomyelitis9.9
45galactosemia9.9
46lung cancer9.9
47specific phobia9.9
48albinism9.9
49spastic paraplegia 19.9
50sialidosis type i9.9

Graphical network of the top 20 diseases related to Mutism:



Diseases related to mutism

Clinical Features for Mutism

About this section

Drugs & Therapeutics for Mutism

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mutism

Drug clinical trials:

Search ClinicalTrials for Mutism

Search NIH Clinical Center for Mutism

Search CenterWatch for Mutism

Genetic Tests for Mutism

About this section

Anatomical Context for Mutism

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mutism:

32
Brain, Liver, Bone, Bone marrow, Lung, Testes, Thyroid, Heart, Eye, Tongue, Skin, Appendix

Animal Models for Mutism or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Mutism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.6FANCL, PICK1, PRNP, MITF, GJB2, SLC6A3
2MP:00036317.7SLC6A3, MBP, DRD5, PICK1, ATP1A3, PRNP

Publications for Mutism

About this section
Sources:
50PubMed
See all sources

Articles related to Mutism:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Evaluation of children with selective mutism and social phobia: a comparison of psychological and psychophysiological arousal. (22569579)
2012
2
Cerebellar mutism: incidence, risk factors and prognosis. (21318616)
2011
3
Novel use of zolpidem in cerebellar mutism syndrome. (21285896)
2011
4
Behavioral and socio-emotional functioning in children with selective mutism: a comparison with anxious and typically developing children across multiple informants. (20496108)
2010
5
Selective mutism: a review of etiology, comorbidities, and treatment. (20436772)
2010
6
Hysterical mutism associated with a diagnosis of lung cancer. (17878510)
2007
7
Practitioner review: Psychosocial interventions for children with selective mutism: a critical evaluation of the literature from 1990-2005. (17076747)
2006
8
Post-traumatic mutism caused by corpus callosum injury diagnosed by fluid-attenuated inversion recovery on magnetic resonance imaging. (15761364)
2005
9
Subarachnoid haemorrhage and akinetic mutism. (15327227)
2004
10
Narrative skills in children with selective mutism: an exploratory study. (15719897)
2004
11
Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis. Case report and review of the literature. (12924716)
2003
12
OKT3 neurotoxicity presenting as akinetic mutism. (12698102)
2003
13
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. (11983799)
2002
14
Akinetic mutism caused by bilateral infiltration of the fornix in a patient with astrocytoma. (11985642)
2002
15
Selective mutism: how a successful speech and language assessment really is possible. (11340767)
2001
16
Akinetic mutism from frontal lobe damage responding to levodopa. (10993505)
2000
17
Elective mutism: effect of dental treatment with N2/O2-inhalation sedation: review and report of case. (10360207)
1999
18
Assessment of brain perfusion by 99mTc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy. (9403207)
1997
19
Elective mutism: an analysis of 100 cases. (8935207)
1996
20
Akinetic mutism with bithalamic infarction. Neurophysiological correlates. (8836973)
1996
21
Psychiatric characteristics of children with selective mutism: a pilot study. (7649954)
1995
22
Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. (8559336)
1995
23
The pathophysiology of oral pharyngeal apraxia and mutism following posterior fossa tumor resection in children. (7666224)
1995
24
Case study: fluoxetine in the multimodal treatment of a preschool child with selective mutism. (7649955)
1995
25
Silent at school--elective mutism and abuse. (8048829)
1994
26
Transient mutism and speech disorders after posterior fossa surgery in children with brain tumours. (7709788)
1994
27
Treatment of elective mutism with fluoxetine: a double-blind, placebo-controlled study. (7961338)
1994
28
The selective mutism controversy (continued) (8150805)
1994
29
Benzodiazepines for catatonic symptoms, stupor, and mutism. (2907648)
1988
30
Mutism and the problem of the mute defendant. (3386466)
1988
31
Hypertrophic cardiomyopathy associated with congenital deaf-mutism. (3609045)
1987
32
Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism. (3080815)
1986
33
Stranger reaction and elective mutism in young children. (3740228)
1986
34
Acute traumatic mutism. (3992456)
1985
35
Deaf-mutism associated with bicuspid aortic valve defect. (6747332)
1984
36
Mutism, akinesis, and fever: a review. (6112976)
1981
37
The syndrome of abnormal neutrophil chemotaxis, unusual facies, proportionate small stature and sensorineural deafness-mutism. (7315301)
1981
38
Behavior therapy in a family context: treating elective mutism. (29775)
1978
39
Mutism in infantile autism, schizophrenia and manic-depressive states: the correlation of clinical psychopathology and linguistics. (4448605)
1974
40
A discussion of the paper by Donald Meltzer on 'Mutism in infantile autism, schizophrenia and manic-depressive states: the correlation of clinical psychopathology and linguistics'. (4475668)
1974
41
Spino-cerebellar degeneration, hormonal disorder, hypogonadism, deaf mutism and mental deficiency. (4671995)
1972
42
Akinetic mutism with recovery after repeated carbon monoxide poisoning. (5148768)
1971
43
A therapeutic approach to speech phobia: elective mutism reexamined. (5101767)
1971
44
Progressive akinetic mutism in cerebellar hemangioblastoma with "normal-pressure hydrocephalus". (5813125)
1969
45
State resembling akinetic mutism in basilar artery occlusion. (6066673)
1967
46
ELECTIVE MUTISM IN CHILDREN: A CLINICAL AND FOLLOW-UP STUDY. (14294732)
1965
47
ELECTIVE MUTISM IN CHILDREN: A RE-APPRAISAL. (14055467)
1963
48
Dynamics and psychotherapy of identical twins with elective mutism. (14475742)
1962
49
A clinical and pathologic study of akinetic mutism. (13812693)
1960
50
The cortical components of akinetic mutism. (14880930)
1951

Genetic Variations for Mutism

About this section

Expression for genes affiliated with Mutism

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mutism

Search GEO for disease gene expression data for Mutism.

Pathways for genes affiliated with Mutism

About this section

Compounds for genes affiliated with Mutism

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
See all sources

Compounds related to Mutism according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1methylphenidate44 49 1112.1SLC6A3, DRD5
2plp (139-151)5910.1PRNP, MBP
3c3bot (154-182)5910.1MBP, PRNP
4ono 25065910.1MBP, PRNP
5nogo-66 (1-40)5910.1MBP, PRNP
6mog (35-55)5910.1MBP, PRNP
7hemocyanin449.9MBP, PRNP
8levodopa44 1110.9DRD5, QDPR, SLC6A3
9pramipexole44 49 28 1112.7SLC6A3, DRD5
10norepinephrine44 11 2411.5SLC6A3, QDPR, DRD5, MBP
11paraffin449.3GJB2, MITF, PRNP, MBP
12glutamate449.0PICK1, PRNP, MITF, SLC6A3, MBP
13lipid448.7MBP, PICK1, PRNP, QDPR, MITF, GJB2

GO Terms for genes affiliated with Mutism

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.6SLC6A3, CNTNAP2, ATP1A3

Biological processes related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transportGO:0158449.9SLC6A3, PICK1
2response to cocaineGO:0422209.7SLC6A3, DRD5
3synaptic transmissionGO:0072689.4SLC6A3, PICK1, DRD5, MBP

Molecular functions related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.0SLC6A3, DRD5

Products for genes affiliated with Mutism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mutism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet