Aliases & Classifications for Mutism

Aliases & Descriptions for Mutism:

Name: Mutism 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4189
MeSH 42 D009155
SNOMED-CT 64 267771000 88052002
UMLS 69 C0026884

Summaries for Mutism

Disease Ontology : 12 A speech disorder that involves a complete inability to speak.

MalaCards based summary : Mutism is related to elective mutism and akinetic mutism, and has symptoms including aphonia, fatigue and sleep disturbances. An important gene associated with Mutism is CNTNAP2 (Contactin Associated Protein-Like 2). The drugs Fluoxetine and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are cellular and growth/size/body region

Related Diseases for Mutism

Diseases related to Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 elective mutism 12.4
2 akinetic mutism 12.3
3 anxiety disorder 11.1
4 dementia, familial, nonspecific 10.8
5 dementia, frontotemporal 10.8
6 syndromic x-linked intellectual disability 12 10.8
7 scoliosis 10.2 CNTNAP2 SLC6A3
8 scrotum basal cell carcinoma 10.1 MAPT SLC6A3
9 cerebritis 10.1
10 protein r deficiency 10.1 GRN MAPT
11 benign partial epilepsy with secondarily generalized seizures in infancy 10.1 MAPT SLC6A3
12 amino acid metabolic disorder 10.1 CNTNAP2 GRN
13 gata1-related thrombocytopenia 10.1 GRN MAPT
14 hereditary paraganglioma-pheochromocytoma syndromes 10.1 GRN MAPT
15 cerebroretinal vasculopathy 10.1 GRN MAPT
16 severe congenital nemaline myopathy 10.1 GRN MAPT
17 andersen syndrome 10.0 GRN MAPT
18 schizophrenia 10.0
19 autism 19 10.0 MAPT SLC6A3
20 acrofrontofacionasal dysostosis 10.0 GRN MAPT
21 postauricular lymphadenitis 10.0 GRN MAPT
22 adult mesenchymal chondrosarcoma 10.0 GRN MAPT
23 mitochondrial dna depletion syndrome 3 10.0 GRN MAPT SLC6A3
24 medulloblastoma 10.0
25 meier-gorlin syndrome 5 10.0 GRN MAPT SLC6A3
26 autoimmune disease of urogenital tract 10.0 GRN MAPT
27 coenzyme q10 deficiency, primary, 1 9.9 GRN MAPT SLC6A3
28 autotopagnosia 9.9 CNTNAP2 GRN MAPT
29 social phobia 9.9
30 personality disorder 9.9 GRN MAPT SLC6A3
31 angina pectoris 9.9 CNTNAP2 GRN MAPT
32 eumycotic mycetoma 9.9 GRN MAPT SLC6A3
33 pancreatic solid pseudopapillary carcinoma 9.9 GRN MAPT
34 cavernous hemangioma 9.9 ATP1A3 MAPT SLC6A3
35 dihydrolipoamide dehydrogenase deficiency 9.9 GJB2 MITF
36 duodenum cancer 9.9 ATP1A3 GJB2 MITF
37 brain stem infarction 9.9
38 hydrocephalus 9.8
39 head injury 9.8
40 substance-induced psychosis 9.8 GJB2 GRN MAPT SLC6A3
41 apraxia 9.8
42 cerebral artery occlusion 9.8
43 obstructive hydrocephalus 9.8
44 goiter 9.7
45 astrocytoma 9.7
46 hemangioblastoma 9.7
47 acute disseminated encephalomyelitis 9.7
48 dysphagia 9.7
49 encephalopathy 9.7
50 lung cancer 9.6

Graphical network of the top 20 diseases related to Mutism:



Diseases related to Mutism

Symptoms & Phenotypes for Mutism

UMLS symptoms related to Mutism:


aphonia, fatigue, sleep disturbances, photophobia, personality changes, scanning speech, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Mutism:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 CNTNAP2 FANCL GJB2 GRN MAPT MITF
2 growth/size/body region MP:0005378 10 ATP1A3 CNTNAP2 FANCL GJB2 MAPT MITF
3 behavior/neurological MP:0005386 9.99 ATP1A3 CNTNAP2 GRN MAPT MITF SLC6A3
4 homeostasis/metabolism MP:0005376 9.98 MITF SLC6A3 ATP1A3 FANCL GJB2 GRN
5 immune system MP:0005387 9.88 ATP1A3 GJB2 GRN MAPT MITF SLC6A3
6 mortality/aging MP:0010768 9.87 ATP1A3 FANCL GJB2 GRN MAPT MITF
7 integument MP:0010771 9.85 CNTNAP2 FANCL GJB2 MAPT MITF SLC6A3
8 nervous system MP:0003631 9.8 ATP1A3 CNTNAP2 GJB2 GRN MAPT MITF
9 craniofacial MP:0005382 9.78 GJB2 MAPT MITF SLC6A3
10 reproductive system MP:0005389 9.35 FANCL GJB2 GRN MITF SLC6A3
11 pigmentation MP:0001186 9.33 FANCL GRN MITF
12 taste/olfaction MP:0005394 8.8 CNTNAP2 MAPT SLC6A3

Drugs & Therapeutics for Mutism

Drugs for Mutism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
2 Antidepressive Agents Phase 3
3 Antidepressive Agents, Second-Generation Phase 3
4 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
5 Cytochrome P-450 Enzyme Inhibitors Phase 3
6 Neurotransmitter Agents Phase 3
7 Neurotransmitter Uptake Inhibitors Phase 3
8 Psychotropic Drugs Phase 3
9
Serotonin Phase 3 50-67-9 5202
10 Serotonin Agents Phase 3
11 Serotonin Uptake Inhibitors Phase 3
12
Menthol Approved 2216-51-5 16666

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Treatment of Childhood Social Phobia Completed NCT00043537 Phase 3
2 Randomised Controlled Treatment Study of Selective Mutism Completed NCT01002196 Phase 2
3 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
4 Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
5 Posterior Fossa Mutism on Quality of Life Completed NCT02048176
6 Integrated Behavioral Therapy for Treating Children With Selective Mutism Completed NCT00458198
7 Web-Based CBT Protocol for Treatment of Selective Mutism Completed NCT02009839
8 What Treatment Works for Children With Selective Mutism? Completed NCT00554749
9 Cerebellar Mutism Syndrome Study Recruiting NCT02300766
10 Treatment of Social Anxiety Disorder and Selective Mutism Recruiting NCT02554929
11 Functional Imaging of Cerebellar Mutism Syndrome Recruiting NCT01733173
12 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069
13 Treating Refractory Schizophrenia With rTMS Recruiting NCT02242578
14 DTI & Tractography in Pediatric Tumor Surgery Not yet recruiting NCT02810626

Search NIH Clinical Center for Mutism

Cochrane evidence based reviews: mutism

Genetic Tests for Mutism

Genetic tests related to Mutism:

id Genetic test Affiliating Genes
1 Mutism 29

Anatomical Context for Mutism

MalaCards organs/tissues related to Mutism:

39
Brain, Liver, Bone, Lung, Neutrophil, Bone Marrow, Thyroid

Publications for Mutism

Articles related to Mutism:

(show top 50) (show all 562)
id Title Authors Year
1
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. ( 27977468 )
2017
2
Apraxia of speech and cerebellar mutism syndrome: a case report. ( 28074148 )
2017
3
Risk factors for development of postoperative cerebellar mutism syndrome in children after medulloblastoma surgery. ( 28498095 )
2017
4
Sudden benzodiazepine-induced resolution of post-operative pediatric cerebellar mutism syndrome: a clinical-SPECT study. ( 28050719 )
2017
5
Social Communication Anxiety Treatment (S-CAT) for children and families with selective mutism: A pilot study. ( 26940121 )
2016
6
Augmentative and Alternative Communication (AAC) for a patient with a nonfluent/ agrammatic variant of PPA in the mutism stage. ( 27007540 )
2016
7
Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results. ( 27142103 )
2016
8
Acquired Mutism and Hypertonia in a Toddler. ( 27364777 )
2016
9
Pediatric selective mutism therapy: a randomized controlled trial. ( 27830922 )
2016
10
Selective mutism and temperament: the silence and behavioral inhibition to the unfamiliar. ( 26970743 )
2016
11
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. ( 27418987 )
2016
12
Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation. ( 27069898 )
2016
13
Identifying Treatment Response of Sertraline in a Teenager with Selective Mutism using Electrophysiological Neuroimaging. ( 27468379 )
2016
14
Selective mutism. ( 26709680 )
2016
15
Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. ( 27942473 )
2016
16
Akinetic mutism revealing an ischemic stroke. ( 27955795 )
2016
17
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. ( 26825206 )
2016
18
Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease. ( 27646053 )
2016
19
Selective Mutism: The Fraternal Twin of Childhood Social Phobia. ( 27089281 )
2016
20
Anxiety and oppositional behavior profiles among youth with selective mutism. ( 26625009 )
2016
21
126a88Anatomy of Cerebellar Mutism: Reduced Fractional Anisotropy in the Superior Cerebellar Peduncle. ( 27399405 )
2016
22
A Case of Mutism in Noncatatonic Schizophrenia Responding to Small Dose of Fluvoxamine Addition to Clozapine. ( 27508430 )
2016
23
A case of mutism on emergence from general anesthesia. ( 26872966 )
2016
24
Mumps encephalitis with akinesia and mutism. ( 25809834 )
2015
25
An auditory-neuroscience perspective on the development of selective mutism. ( 25625220 )
2015
26
Mutism in non-catatonic schizophrenia: Psychotic symptom and adaptive behavioral strategy. ( 26144881 )
2015
27
The use of medication in selective mutism: a systematic review. ( 26560144 )
2015
28
Cerebellar mutism. ( 26351234 )
2015
29
Children Who are Anxious in Silence: A Review on Selective Mutism, the New Anxiety Disorder in DSM-5. ( 25724675 )
2015
30
Remarkable improvement of selective mutism with everolimus in a patient with tuberous sclerosis complex. ( 25784638 )
2015
31
A Selective Mutism Arising from First Language Attrition, Successfully Treated with Paroxetine-CBT Combination Treatment. ( 26508972 )
2015
32
Cerebellar mutism following closed head injury in a child. ( 25685374 )
2015
33
Absence of Nails, Deaf-mutism, Seizures, and Intellectual Disability: A Case Report. ( 26023614 )
2015
34
The outcome of children with selective mutism following cognitive behavioral intervention: a follow-up study. ( 26498645 )
2015
35
Ties of silence - Family lived experience of selective mutism in identical twins. ( 26092264 )
2015
36
Children of Few Words: Relations Among Selective Mutism, Behavioral Inhibition, and (Social) Anxiety Symptoms in 3- to 6-Year-Olds. ( 25842046 )
2015
37
Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. ( 26145481 )
2015
38
Cerebellar mutism after posterior fossa tumor resection: case discussion and recommendations for psychoeducational intervention. ( 24608700 )
2014
39
Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session. ( 25535609 )
2014
40
A girl with tuberous sclerosis complex presenting with severe epilepsy and electrical status epilepticus during sleep, and with high-functioning autism and mutism. ( 24968009 )
2014
41
Unique presentation of akinetic mutism and coexisting thyroid storm relating to stroke. ( 25530892 )
2014
42
Cause and outcome of cerebellar mutism: evidence from a systematic review. ( 24452481 )
2014
43
Cerebellar mutism in acute disseminating encephalomyelitis. ( 24656209 )
2014
44
Selective mutism: follow-up study 1A year after end of treatment. ( 25267381 )
2014
45
The anatomical substrate of cerebellar mutism. ( 24735842 )
2014
46
Fluorodeoxyglucose positron emission tomography/computed tomography findings in a patient with cerebellar mutism after operation in posterior fossa. ( 24650725 )
2014
47
Cerebellar mutism: the rehabilitation challenge in pediatric neuro-oncology: case studies. ( 25547885 )
2014
48
Cerebellar mutism. ( 23398780 )
2013
49
Comparison of behavioral profiles for anxiety-related comorbidities including ADHD and selective mutism in children. ( 23526795 )
2013
50
Tractography demonstrates dentate-rubro-thalamic tract disruption in an adult with cerebellar mutism. ( 23546861 )
2013

Variations for Mutism

ClinVar genetic disease variations for Mutism:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SHANK3 NM_033517.1(SHANK3): c.3637dupC (p.His1213Profs) duplication Pathogenic GRCh37 Chromosome 22, 51159898: 51159898

Expression for Mutism

Search GEO for disease gene expression data for Mutism.

Pathways for Mutism

GO Terms for Mutism

Cellular components related to Mutism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.26 GJB2 MAPT
2 neuronal cell body GO:0043025 9.26 ATP1A3 CNTNAP2 MAPT SLC6A3
3 axolemma GO:0030673 9.16 CNTNAP2 MAPT
4 axon GO:0030424 8.92 ATP1A3 CNTNAP2 MAPT SLC6A3

Biological processes related to Mutism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 8.96 ATP1A3 CNTNAP2
2 memory GO:0007613 8.62 ATP1A3 MAPT

Molecular functions related to Mutism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 8.62 MAPT SLC6A3

Sources for Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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