Summaries for Mutism

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Disease Ontology:10 A speech disorder that involves a complete inability to speak.

MalaCards based summary: Mutism is related to akinetic mutism and schizophrenia. An important gene associated with Mutism is GJB2 (gap junction protein, beta 2, 26kDa), and among its related pathways are Fatty acid metabolism and Biosynthesis of unsaturated fatty acids. The compounds plp (139-151) and c3bot (154-182) have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related mouse phenotypes are normal and reproductive system.

Aliases & Classifications for Mutism

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Mutism, Aliases & Descriptions:

Name: Mutism 10 12 62


External Ids:

Disease Ontology10 DOID:4189
SNOMED-CT57 267771000, 88052002
MeSH35 D009155

Related Diseases for Mutism

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Diseases related to Mutism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 337)
idRelated DiseaseScoreTop Affiliating Genes
1akinetic mutism31.2MBP, ACAA2, PRNP, TXNDC9, PNMA2
2schizophrenia30.5SLC6A3, MBP
3pendred syndrome29.8GJB2
4supranuclear palsy, progressive29.8PRNP, SLC6A3
5wilson disease29.7PRNP, SLC6A3
6encephalitis29.7CNTNAP2, PNMA2, MBP
7elective mutism10.7
8cerebritis10.4
9medulloblastoma10.3
10social phobia10.2
11brain stem infarction10.2
12hydrocephalus10.2
13anxiety disorder10.2
14head injury10.2
15cerebral artery occlusion10.1
16obstructive hydrocephalus10.1
17mental retardation10.1
18acute disseminated encephalomyelitis10.0
19apraxia10.0
20goiter10.0
21hemangioblastoma10.0
22keratoderma10.0
23dysphagia10.0
24prion disease10.0TXNDC9, PNMA2
25aids dementia complex10.0SLC6A3, MBP
26vascular dementia10.0PRNP, MBP
27dementia, lewy body10.0SLC6A3, PRNP
28central nervous system disease10.0MBP, SLC6A3
29movement disease10.0ATP1A3, SLC6A3
30gilles de la tourette syndrome10.0CNTNAP2, SLC6A3
31multiple system atrophy10.0PRNP, MBP, SLC6A3
32epilepsy syndrome10.0PRNP, SLC6A3, MBP
33waardenburg's syndrome10.0GJB2, MITF
34zellweger syndrome10.0ACAA2, ACOX3
35neurofibroma10.0MBP, MITF
36toxic encephalopathy10.0SLC6A3, PRNP
37brain disease10.0PRNP, MBP
38neurilemmoma10.0MITF, MBP
39sensorineural hearing loss10.0GJB2, MITF
40creutzfeldt-jakob disease10.0
41masa syndrome10.0
42lung cancer10.0
43sialidosis, type i10.0
44fragile x syndrome10.0
45brain injury10.0
46paranoid schizophrenia10.0
47choroiditis10.0
48tuberous sclerosis10.0
49basilar artery occlusion10.0
50anterior cerebral artery infarction10.0

Graphical network of the top 20 diseases related to Mutism:



Diseases related to mutism

Symptoms for Mutism

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Drugs & Therapeutics for Mutism

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Drug clinical trials:

Search ClinicalTrials for Mutism

Search NIH Clinical Center for Mutism

Genetic Tests for Mutism

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Anatomical Context for Mutism

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MalaCards organs/tissues related to Mutism:

33
Brain, Liver, Bone, Bone marrow, Lung, Thyroid, Neutrophil, Eye, Heart, Skin, Testes, Tongue, Appendix

Animal Models for Mutism or affiliated genes

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MGI Mouse Phenotypes related to Mutism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8SLC6A3, MBP, GJB2, MITF, PRNP
2MP:00053898.6SLC6A3, MBP, GJB2, MITF, PRNP, FANCL
3MP:00053868.3ATP1A3, PRNP, MITF, CNTNAP2, MBP, SLC6A3
4MP:00053788.3ATP1A3, FANCL, PRNP, MITF, CNTNAP2, GJB2
5MP:00036318.2ATP1A3, PRNP, MITF, CNTNAP2, GJB2, MBP
6MP:00053768.2ATP1A3, FANCL, PRNP, MITF, GJB2, MBP
7MP:00053848.1FANCL, PRNP, CNTNAP2, GJB2, MBP, SLC6A3
8MP:00107688.0ATP1A3, FANCL, PRNP, MITF, GJB2, MBP

Publications for Mutism

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Articles related to Mutism:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Cerebellar Mutism Caused by Primary Varicella Infection in an Immunocompetent Child. (23446802)
2013
2
Cerebellar mutism. (23398780)
2013
3
Selective mutism: a team approach to assessment and treatment in the school setting. (21970860)
2012
4
Dysarthria and mutism. (22377870)
2012
5
Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate. (22672948)
2012
6
Vegetative state, minimally conscious state, akinetic mutism and Parkinsonism as a continuum of recovery from disorders of consciousness: an exploratory and preliminary study. (21693084)
2011
7
Acute mutism: a useful lesson. (20659887)
2011
8
Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. (20713408)
2010
9
Cerebellar mutism in pediatric acute disseminated encephalomyelitis. (20304329)
2010
10
Transient mutism and pathologic laughter in the course of cerebellitis. (19520276)
2009
11
Persistent akinetic mutism after bilateral paramedian thalamic infarction. (19776325)
2009
12
Increased left prefrontal activation during staring/mutism episodes in a patient with resistant catatonic schizophrenia: a near infrared spectroscopy study. (18327023)
2008
13
Treatment of akinetic mutism with intramuscular olanzapine: a case series. (18305290)
2008
14
Hysterical mutism associated with a diagnosis of lung cancer. (17878510)
2007
15
Clinical case rounds in child and adolescent psychiatry: commentary on selective mutism. (18392159)
2007
16
Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report. (16509510)
2006
17
Practitioner review: Psychosocial interventions for children with selective mutism: a critical evaluation of the literature from 1990-2005. (17076747)
2006
18
Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison's disease. (16682841)
2006
19
Behavioral and emotional adjustment, family functioning, academic performance, and social relationships in children with selective mutism. (15482497)
2004
20
Mutism as a complication of total intravenous anesthesia by propofol. (14633577)
2003
21
Prevalence and description of selective mutism in immigrant and native families: a controlled study. (14627880)
2003
22
Selective mutism and obsessive compulsive disorders associated with zonisamide. (12237077)
2002
23
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. (11983799)
2002
24
Phenomenology and treatment of selective mutism. (11888338)
2002
25
Elective mutism: effect of dental treatment with N2/O2-inhalation sedation: review and report of case. (10360207)
1999
26
Selective mutism. (10071945)
1999
27
A double-blind comparison of lorazepam and oxazepam in psychomotor retardation and mutism. (10435212)
1999
28
Transient mutism after brain stem infarction (ref. Acta Neurochirurgia 1999, 141: 209-213) (10536732)
1999
29
Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma. (9856479)
1998
30
Case study: audio feedforward treatment of selective mutism. (9444898)
1998
31
Cyclosporine mutism. (9008554)
1997
32
Mutilating keratoderma with deaf-mutism. (20948071)
1996
33
Elective mutism: an analysis of 100 cases. (8935207)
1996
34
Cerebellar mutism following posterior fossa tumour surgery. (8861318)
1996
35
Fluoxetine for (s)elective mutism. (7608040)
1995
36
The syndrome of 'cerebellar' mutism and subsequent dysarthria. (7969956)
1994
37
Transient mutism after posterior fossa surgery. (7923241)
1994
38
Transient mutism following posterior fossa surgery in children. (8121185)
1994
39
A parent comments on elective mutism. (8496136)
1993
40
Elective mutism and mental retardation. (8340310)
1993
41
Is elective mutism a social phobia? (8407760)
1993
42
Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings. (1573414)
1992
43
Treatment of a case of akinetic mutism with bromocriptine. (2136401)
1990
44
Mutism, malingering, and competency to stand trial. (3676530)
1987
45
Mutism following left hemisphere infarction. (6210346)
1984
46
Elective mutism in a 26 year old deaf female. (6839269)
1983
47
Articulatory recovery after traumatic mutism. (6654280)
1983
48
Elective mutism. (420040)
1979
49
Mutism in infantile autism, schizophrenia and manic-depressive states: the correlation of clinical psychopathology and linguistics. (4448605)
1974
50
DIAGNOSIS AND TREATMENT OF ELECTIVE MUTISM IN CHILDREN. (14281154)
1964

Variations for Mutism

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Expression for genes affiliated with Mutism

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Search GEO for disease gene expression data for Mutism.

Pathways for genes affiliated with Mutism

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Pathways related to Mutism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.1ACAA2, ACOX3
2
Show member pathways
oleate biosynthesis II (animals)38
9.1ACAA2, ACOX3

Compounds for genes affiliated with Mutism

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Sources:
61Tocris Bioscience, 45Novoseek, 26HMDB, 13DrugBank
See all sources

Compounds related to Mutism according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1plp (139-151)6110.0MBP, PRNP
2c3bot (154-182)6110.0PRNP, MBP
3ono 25066110.0PRNP, MBP
4nogo-66 (1-40)619.9PRNP, MBP
5mog (35-55)619.9PRNP, MBP
6hemocyanin459.7MBP, PRNP
7potassium45 26 1311.5GJB2, CNTNAP2, ATP1A3
8Tetradecanoyl-CoA269.2ACAA2, ACOX3
9paraffin459.2PRNP, MITF, GJB2, MBP
10aspartate459.2PRNP, GJB2, MBP, SLC6A3
11arginine459.0PRNP, MITF, MBP, SLC6A3
12glutamate458.8SLC6A3, MBP, MITF, PRNP

GO Terms for genes affiliated with Mutism

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Cellular components related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.3SLC6A3, MBP, CNTNAP2
2axonGO:00304249.1SLC6A3, CNTNAP2, ATP1A3

Molecular functions related to Mutism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.7SLC6A3, MBP

Products for genes affiliated with Mutism

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Sources for Mutism

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet