MCID: MTY001
MIFTS: 35

Mutyh-Associated Polyposis malady

Genetic category

Summaries for Mutyh-Associated Polyposis

Sources:
43NIH Rare Diseases, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Myh-associated polyposis is an inherited condition characterized by the development of multiple adenomatous colon polyps and an increased risk of colorectal cancer. this condition, a milder form of familial adenomatous polyposis (fap), is sometimes called autosomal recessive familial adenomatous polyposis because it is inherited in an autosomal recessive manner. people with this condition have fewer polyps than those with the classic type of fap; fewer than 100 polyps typically develop, rather than hundreds or thousands. they may also be at increased risk for upper gastrointestinal polyps. myh-associated polyposis is caused by mutations in the myh gene. last updated: 6/28/2011

MalaCards: Mutyh-Associated Polyposis, also known as myh-associated polyposis, is related to adenoma and colorectal cancer. An important gene associated with Mutyh-Associated Polyposis is MUTYH (mutY homolog), and among its related pathways are Thyroid cancer and Akt Signaling Pathway . The compounds guanine and 8-oxo-dg have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

GeneReviews summary for maps

Aliases & Classifications for Mutyh-Associated Polyposis

Sources:
19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

mutyh-associated polyposis 19 20
myh-associated polyposis 19 43 22 61
colorectal adenomatous polyposis, autosomal recessive 19
autosomal recessive familial adenomatous polyposis 43
multiple colorectal adenomas, autosomal recessive 19
map syndrome 43


Related Diseases for Mutyh-Associated Polyposis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mutyh-Associated Polyposis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8APC, MUTYH, KRAS, SMAD4, TP53
2colorectal cancer30.8TP53, SMAD4, KRAS, MUTYH, APC
3thyroid cancer30.3TP53, APC
4adenocarcinoma30.3APC, KRAS, SMAD4, TP53
5familial adenomatous polyposis30.3APC, MUTYH, KRAS, SMAD4, TP53
6colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.5
7familial colorectal cancer10.4
8desmoid tumor10.3
9germ cell tumors10.3
10testicular germ cell tumor10.3
11tumor predisposition syndrome10.2
12adenomas, multiple colorectal10.2
13esophageal cancer10.0TP53
14ulcerative colitis10.0TP53
15bladder carcinoma10.0TP53
16kidney cancer10.0TP53
17pancreas disease10.0SMAD4
18juvenile myelomonocytic leukemia10.0KRAS
19leiomyoma10.0SMAD4
20cystadenoma10.0KRAS
21peutz-jeghers syndrome10.0APC
22intestinal neoplasm10.0APC
23nephroblastoma10.0TP53
24turcot syndrome10.0APC
25fibrous dysplasia10.0APC
26adrenocortical carcinoma10.0TP53
27biliary tract cancer10.0SMAD4
28melanoma10.0TP53, KRAS
29lung cancer10.0TP53, KRAS
30malignant mixed mullerian tumor10.0KRAS, TP53
31seminoma10.0SMAD4, KRAS
32leukemia10.0KRAS, TP53
33pancreatitis10.0SMAD4, KRAS
34glioblastoma multiforme10.0SMAD4, TP53
35cervical squamous cell carcinoma10.0KRAS
36gastric cancer, somatic10.0MUTYH, APC
37colon adenocarcinoma10.0SMAD4, KRAS
38pancreatitis, chronic10.0SMAD4, KRAS
39nasopharynx carcinoma10.0TP53, SMAD4
40juvenile polyposis syndrome10.0APC, SMAD4
41barrett's esophagus10.0TP53, APC
42gastrinoma10.0APC, SMAD4
43pancreatic cancer10.0SMAD4, KRAS
44cholangiocarcinoma10.0TP53, SMAD4, KRAS
45lung adenocarcinoma10.0KRAS, SMAD4, TP53
46cervical cancer10.0TP53, SMAD4, KRAS
47rectum cancer10.0APC, MUTYH, KRAS
48endometrial carcinoma10.0KRAS, SMAD4, TP53
49gallbladder cancer10.0TP53, KRAS, APC
50ovarian cancer10.0KRAS, SMAD4, TP53

Graphical network of the top 20 diseases related to Mutyh-Associated Polyposis:



Diseases related to mutyh-associated polyposis

Clinical Features for Mutyh-Associated Polyposis

Drugs & Therapeutics for Mutyh-Associated Polyposis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Mutyh-Associated Polyposis

Genetic Tests for Mutyh-Associated Polyposis

Sources:
20GeneTests, 22GTR
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Genetic tests related to Mutyh-Associated Polyposis:

id Genetic test Affiliating Genes
1 Mutyh-associated Polyposis20 MUTYH
2 Myh-associated Polyposis22

Anatomical Context for Mutyh-Associated Polyposis

Sources:
33MalaCards
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MalaCards organs/tissues related to Mutyh-Associated Polyposis:

33
Colon

Animal Models for Mutyh-Associated Polyposis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Mutyh-Associated Polyposis

Genetic Variations for Mutyh-Associated Polyposis

Expression for genes affiliated with Mutyh-Associated Polyposis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mutyh-Associated Polyposis

Search GEO for disease gene expression data for Mutyh-Associated Polyposis.

Pathways for genes affiliated with Mutyh-Associated Polyposis

Sources:
30KEGG, 53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
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Pathways related to Mutyh-Associated Polyposis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4KRAS, TP53
29.4TP53, KRAS
3
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.4TP53, KRAS
49.3KRAS, SMAD4
59.3TP53, SMAD4
69.3TP53, SMAD4
79.3TP53, SMAD4
8
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9.3TP53, SMAD4
9
Signal transduction JNK pathway
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9.3TP53, SMAD4
109.1TP53, APC
119.1APC, TP53
12
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8.8KRAS, SMAD4, TP53
13
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8.8KRAS, SMAD4, TP53
148.8KRAS, SMAD4, TP53
158.6TP53, KRAS, APC
16
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8.6TP53, KRAS, APC
17
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8.6TP53, KRAS, APC
18
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8.5TP53, SMAD4, APC
19
Hide members
8.5APC, SMAD4, TP53
20
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8.0TP53, SMAD4, KRAS, APC
218.0TP53, SMAD4, KRAS, APC
228.0APC, KRAS, SMAD4, TP53
238.0APC, KRAS, SMAD4, TP53

Compounds for genes affiliated with Mutyh-Associated Polyposis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Mutyh-Associated Polyposis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1guanine45 11 2412.3MUTYH
28-oxo-dg459.7MUTYH, TP53
3oxaliplatin45 50 1111.5TP53, KRAS
4af/ap459.5MUTYH, APC
58-oxoguanine459.4APC, MUTYH
6leptomycin b45 6010.4TP53, SMAD4
75-methylcytosine45 2410.4APC, TP53
8irinotecan45 50 1111.3TP53, KRAS
9sulindac45 1110.3TP53, APC
10methylmethanesulfonate459.3APC, TP53
11nocodazole45 1110.1TP53, APC
12o6-methylguanine458.9APC, KRAS, TP53
13h2o2458.7TP53, KRAS, MUTYH
14crcs458.3TP53, SMAD4, KRAS, APC
15paraffin458.3APC, KRAS, SMAD4, TP53
16oligonucleotide458.3APC, KRAS, SMAD4, TP53
17serine458.0APC, KRAS, SMAD4, TP53

GO Terms for genes affiliated with Mutyh-Associated Polyposis

Sources:
16Gene Ontology
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Biological processes related to Mutyh-Associated Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Ras protein signal transductionGO:0072659.4TP53, KRAS
2base-excision repairGO:0062849.4TP53, MUTYH
3T cell differentiation in thymusGO:0330779.1TP53, APC
4negative regulation of cell proliferationGO:0082858.2TP53, SMAD4, APC

Molecular functions related to Mutyh-Associated Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.3TP53, SMAD4

Products for genes affiliated with Mutyh-Associated Polyposis

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Sources for Mutyh-Associated Polyposis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet