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12Gene Ontology
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Cellular components related to myasthenia according to GeneDecks: (show all 21)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | MHC class II protein complex | GO:042613 | 10.7 | HLA-DPB1, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1 | | 2 | endocytic vesicle membrane | GO:030666 | 10.7 | HLA-DPB1, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, VAMP2 | | 3 | clathrin-coated endocytic vesicle membrane | GO:030669 | 10.6 | HLA-DRB1, HLA-DPB1, HLA-DRA, HLA-DQB1, HLA-DQA1 | | 4 | integral to lumenal side of endoplasmic reticulum membrane | GO:071556 | 10.5 | HLA-G, HLA-A, HLA-C, HLA-E, HLA-DRB1, HLA-DRA | | 5 | trans-Golgi network membrane | GO:032588 | 10.5 | HLA-DRA, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1 | | 6 | MHC class I protein complex | GO:042612 | 10.5 | HLA-A, HLA-G, HLA-E, HLA-C, HLA-B | | 7 | ER to Golgi transport vesicle membrane | GO:012507 | 10.5 | HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1 | | 8 | transport vesicle membrane | GO:030658 | 10.3 | HLA-DRB1, HLA-DRA, HLA-DPB1, HLA-DQA1, HLA-DQB1 | | 9 | phagocytic vesicle membrane | GO:030670 | 10.3 | HLA-E, HLA-G, HLA-C, HLA-B, HLA-A | | 10 | basal lamina | GO:005605 | 10.2 | ACHE, COLQ, LAMB2, AGRN | | 11 | neuromuscular junction | GO:031594 | 10.0 | MUSK, CHRNA1, RAPSN, DOK7, DES | | 12 | protein complex | GO:043234 | 9.9 | RYR2, NR3C1, DMD, TNFRSF1A, AKAP5, ALB | | 13 | cell junction | GO:030054 | 9.6 | CHRNG, CHRNB1, ACHE, COLQ, DOK7, MUSK | | 14 | integral to plasma membrane | GO:005887 | 9.6 | CTLA4, CD40LG, CD28, TPO, TRPC3, HLA-DRB1 | | 15 | external side of plasma membrane | GO:009897 | 9.6 | CXCR3, CCR5, FAS, AQP4, IL6ST, IL2RB | | 16 | neuronal cell body | GO:043025 | 9.5 | IL6ST, APOE, KCND3, CHAT, MBP, CCR2 | | 17 | acetylcholine-gated channel complex | GO:005892 | 9.3 | CHRNA1, CHRND, CHRNB1, CHRNE | | 18 | cell surface | GO:009986 | 8.7 | TNF, TGFB1, ABCB1, CCR5, NCAM1, LGALS1 | | 19 | plasma membrane | GO:005886 | 7.5 | DOK7, HLA-DPB1, HLA-C, HLA-B, HLA-A, AIRE | | 20 | extracellular space | GO:005615 | 6.5 | MMP2, CD40LG, LGALS1, TNFSF13, TNFRSF1A, TNF | | 21 | extracellular region | GO:005576 | 6.3 | ACHE, PLEK, TNFRSF1A, ESR2, CALCA, HSPG2 |
Biological processes related to myasthenia according to GeneDecks: (show top 50)
(show all 74)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | T cell costimulation | GO:031295 | 11.0 | PDCD1, CD28, CD86, CD80, HLA-DPB1, HLA-DRB1 | | 2 | positive regulation of isotype switching to IgG isotypes | GO:048304 | 10.8 | IL4, IFNG, PTPRC, IL2 | | 3 | positive regulation of MHC class II biosynthetic process | GO:045348 | 10.7 | CIITA, CD40LG, IL10, IL4, IFNG, TLR4 | | 4 | positive regulation of tissue remodeling | GO:034105 | 10.7 | IL2, IL18, IL12B, IL15 | | 5 | positive regulation of T cell proliferation | GO:042102 | 10.7 | PTPRC, IL12B, CD276, TNFRSF13C, IFNG, IL6ST | | 6 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | GO:014808 | 10.7 | RYR1, CCR5, RYR2, CCL3 | | 7 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | GO:002480 | 10.7 | HLA-G, HLA-E, HLA-C, HLA-A, HLA-B | | 8 | negative regulation of growth of symbiont in host | GO:044130 | 10.6 | IL10, IL12B, IFNG, TNF, LTA | | 9 | positive regulation of inflammatory response | GO:050729 | 10.6 | IL2, TLR4, TNFRSF1A, CCL3, CCR2, IL18 | | 10 | regulation of immune response | GO:050776 | 10.6 | CD40LG, HLA-E, HLA-A, C3, HLA-C, CD276 | | 11 | positive regulation of interleukin-17 production | GO:032740 | 10.5 | IL18, IL15, IL12B, TGFB1, IL2 | | 12 | interferon-gamma-mediated signaling pathway | GO:060333 | 10.5 | NCAM1, CIITA, IFNG, HLA-A, HLA-B, HLA-C | | 13 | cellular response to interferon-gamma | GO:071346 | 10.5 | IL12B, CCL3, CCL2, IL18, AQP4 | | 14 | positive regulation of tumor necrosis factor production | GO:032760 | 10.5 | IL12B, TLR4, TNFRSF1A, IFNG, CCL3, IL18 | | 15 | negative regulation of T cell proliferation | GO:042130 | 10.4 | FOXP3, IL10, HLA-DRB1, TGFB1, HLA-G, CD276 | | 16 | negative regulation of interleukin-17 production | GO:032700 | 10.4 | TLR4, IFNG, IL12A, IL12B | | 17 | B cell proliferation | GO:042100 | 10.4 | PTPRC, BCL2, CD79A, CD40LG, IL10, IFNB1 | | 18 | chemotaxis | GO:006935 | 10.4 | CCR2, CCR5, CCL4, CXCL12, CXCL10, CCL3 | | 19 | synaptic transmission | GO:007268 | 10.4 | ACHE, RAPSN, VAMP2, CHRNE, VIPR1, GAD1 | | 20 | positive regulation of interferon-gamma production | GO:032729 | 10.4 | IL18, IL12A, IL12B, IL2, CCR2, TNF | | 21 | positive regulation of B cell proliferation | GO:030890 | 10.4 | CD40LG, PTPRC, TNFRSF4, TNFRSF13C, TLR4, IL5 | | 22 | positive regulation of immunoglobulin secretion | GO:051024 | 10.4 | TNFRSF4, IL6, IL5, IL2 | | 23 | cell surface receptor signaling pathway | GO:007166 | 10.4 | CCL2, PRL, PTPRC, IFNG, CD28, IFNB1 | | 24 | positive regulation of neuron apoptotic process | GO:043525 | 10.3 | MUSK, RAPSN, IL18, CCL3, TNF, NR3C1 | | 25 | regulation of sensory perception of pain | GO:051930 | 10.3 | IL1A, TLR4, ADRB2, CCL3, IL10 | | 26 | defense response to virus | GO:051607 | 10.3 | BCL2, CD86, IFNB1, CXCL10, PTPRC, IFNG | | 27 | muscle contraction | GO:006936 | 10.3 | UTRN, CHRNG, CACNA1S, CHRNB1, RYR1, CHRNE | | 28 | cell-cell signaling | GO:007267 | 10.3 | IL18, IL17A, IL10, INS, AR, CD80 | | 29 | chemokine-mediated signaling pathway | GO:070098 | 10.2 | CCR5, CCR2, CXCL12, CXCR3, CCL2 | | 30 | humoral immune response | GO:006959 | 10.1 | AIRE, TNF, IFNG, BCL2, CCL2, PDCD1 | | 31 | positive regulation of interleukin-12 production | GO:032735 | 10.1 | IL12B, IFNG, HLA-G, TLR4, CD40LG | | 32 | response to lipopolysaccharide | GO:032496 | 10.1 | IL12A, CXCL10, IL1A, TNFRSF1A, TLR4, LTA | | 33 | immune response | GO:006955 | 10.1 | VIPR1, IL18, IL1A, IL2, IL2RA, CIITA | | 34 | cellular response to organic cyclic compound | GO:071407 | 10.0 | LGALS1, TNF, CCL3, CCL2, IL18, HSP90AB1 | | 35 | aging | GO:007568 | 9.9 | FAS, IL15, CCL2, F3, CALCA, NR3C1 | | 36 | lymph node development | GO:048535 | 9.9 | IL15, CXCL13, LTA, TGFB1 | | 37 | lipopolysaccharide-mediated signaling pathway | GO:031663 | 9.9 | TLR4, IL18, CCL2, CCL3, TNF, TGFB1 | | 38 | response to radiation | GO:009314 | 9.9 | NR3C1, IL18, MMP9, BCL2, TGFB1, CXCL12 | | 39 | positive regulation of nitric oxide biosynthetic process | GO:045429 | 9.8 | HSP90AA1, TLR4, INS, IFNG, HSP90AB1, ESR1 | | 40 | positive regulation of cell proliferation | GO:008284 | 9.8 | INS, AR, CD86, VIP, CNTFR, VIPR1 | | 41 | cellular calcium ion homeostasis | GO:006874 | 9.7 | DMPK, CCR2, RYR2, CXCL12, TGFB1, CCL3 | | 42 | anti-apoptosis | GO:006916 | 9.7 | HSP90B1, CD40LG, TNF, F3, CCL2, NR3C1 | | 43 | cytokine-mediated signaling pathway | GO:019221 | 9.6 | CCR2, CCL2, IFNB1, IFNG, HLA-A, HLA-B | | 44 | MAPK cascade | GO:000165 | 9.6 | TNF, TGFB1, INS, CCL3, CCR5, CCL2 | | 45 | response to toxin | GO:009636 | 9.5 | CCL4, BCL2, CCL3, PON1, TLR4, MBP | | 46 | signal transduction | GO:007165 | 9.4 | CCL4, HSP90AA1, C3, CXCL13, ESR2, TNFRSF17 | | 47 | response to drug | GO:042493 | 9.4 | MMP9, CCL2, LGALS1, GAD1, CHAT, IFNG | | 48 | positive regulation of transcription from RNA polymerase II promoter | GO:045944 | 9.3 | IL6, IFNB1, IFNG, ESR1, AIRE, TNF | | 49 | inflammatory response | GO:006954 | 9.3 | IL15, CCL3, IL18, IL1A, IL5, IL6 | | 50 | response to hypoxia | GO:001666 | 9.0 | BCL2, RYR1, CXCL12, TGFB1, TNFRSF1A, CHAT |
Molecular functions related to myasthenia according to GeneDecks: (show all 12)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | MHC class I receptor activity | GO:032393 | 10.4 | HLA-G, HLA-E, HLA-B, HLA-A, HLA-C | | 2 | tumor necrosis factor-activated receptor activity | GO:005031 | 10.4 | TNFRSF1A, FAS, TNFRSF17, TNFRSF4 | | 3 | MHC class II receptor activity | GO:032395 | 10.3 | HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DRB1 | | 4 | tumor necrosis factor receptor binding | GO:005164 | 10.3 | CD40LG, TNF, TNFSF13, TNFSF13B, LTA | | 5 | chemokine activity | GO:008009 | 10.2 | CXCL13, CXCL12, CXCL10, CCL21, CCL3, CCL4 | | 6 | acetylcholine-activated cation-selective channel activity | GO:004889 | 10.2 | CHRND, CHRNG, CHRNE, CHRNB1 | | 7 | receptor binding | GO:005102 | 10.1 | CXCL10, CALCA, C3, CNTFR, CD276, AR | | 8 | protease binding | GO:002020 | 9.9 | BCL2, RYR1, TNFRSF1A, TNF, F3, MBP | | 9 | cytokine activity | GO:005125 | 9.8 | IL5, CCL4, IL6, IL4, IL32, IL2 | | 10 | growth factor activity | GO:008083 | 9.4 | IL10, IL12A, IL12B, IL2, IL5, CXCL12 | | 11 | protein homodimerization activity | GO:042803 | 8.3 | ADRB2, CCR2, APOE, IL6ST, IL12B, FOXP3 | | 12 | protein binding | GO:005515 | 5.7 | CD276, VAMP2, MYOZ2, UTRN, BCL2, INS |
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