MCID: MYS003
MIFTS: 64

Myasthenia Gravis malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Myasthenia Gravis

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Sources:
30LifeMap Discovery®, 9Disease Ontology, 41NIH Rare Diseases, 21Genetics Home Reference, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 32MedlinePlus, 60UMLS, 55SNOMED-CT, 38NCIt, 27ICD9CM, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Myasthenia Gravis, Aliases & Descriptions:

Name: Myasthenia Gravis 30 9 41 21 42 11 43 47 22 32 60
Autoimmune Myasthenia Gravis 41 47
 
Acquired Myasthenia 41 47
Mg 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
myasthenia gravis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe),1-5/10000 (Worldwide),1-9/1000000 (United States),1-5/10000 (Canada),1-9/100000 (Spain),1-5/10000 (United Kingdom),1-9/100000 (United Kingdom),1-9/100000 (Serbia),1-5/10000 (United States),1-5/10000 (Serbia),1-9/100000 (Italy),1-5/10000 (Austria),1-9/100000 (Australia),1-5/10000 (Italy),1-9/100000 (Taiwan, Province of China),1-5/10000 (Australia),1-9/1000000 (Greece),1-5/10000 (Taiwan, Province of China),1-9/1000000 (Croatia),1-9/100000 (Estonia),1-9/100000 (Greece),1-9/100000 (Croatia); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:437
NCIt38 C60989
ICD9CM27 358.0
MeSH33 D009157
Orphanet47 589
MESH via Orphanet34 D009157
ICD10 via Orphanet26 G70.0
UMLS via Orphanet61 C0026896
ICD1025 G70.0

Summaries for Myasthenia Gravis

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MedlinePlus:32 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest.. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke

MalaCards based summary: Myasthenia Gravis, also known as autoimmune myasthenia gravis, is related to thymoma and systemic lupus erythematosus. An important gene associated with Myasthenia Gravis is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Activation of Nicotinic Acetylcholine Receptors and Cytokine Network. The drugs cyclosporine and cyclophosphamide and the compounds edrophonium and gallamine have been mentioned in the context of this disorder. Affiliated tissues include eye, thymus and skeletal muscle, and related mouse phenotypes are integument and liver/biliary system.

NIH Rare Diseases:41 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. last updated: 3/11/2009

NINDS:42 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.

Genetics Home Reference:21 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.

Wikipedia:63 Myasthenia gravis (from Greek ??? \"muscle\", ???????? \"weakness\", and Latin: gravis \"serious\";... more...

Related Diseases for Myasthenia Gravis

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Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Acquired Myasthenia Gravis

Diseases related to Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.5MUSK, CTLA4, RYR1, TNFRSF4, TTN
2systemic lupus erythematosus31.1FCGR2A, TNFSF13B
3congenital myasthenic syndrome31.1CHRNG, MUSK, CHRNA1
4polymyositis30.9TTN, CTLA4
5respiratory failure30.8MUSK, TTN, RYR1
6meningitis30.7FCGR2A
7lepromatous leprosy30.7LTA, IL10
8uveitis30.7LTA, CTLA4, IL10
9myopathy30.7RAPSN, TTN, ACHE, RYR1
10neuromuscular disease30.6MUSK, RYR1, TTN
11neuropathy30.6RYR1, RAPSN, TTN
12hepatitis c30.5TNFSF13B, IL10, CTLA4
13tetanus30.5IL10, LTA, ACHE
14graves' disease30.4CTLA4, LTA, TNFRSF4, HLA-DQB1
15arthritis30.3LTA, FCGR2A, IL10, CTLA4
16asthma30.2TNFRSF4, TNFSF13B, IL10, CTLA4
17autoimmune hepatitis30.1HLA-DQB1, CTLA4
18rheumatoid arthritis29.1FCGR2A, HLA-DQB1, CTLA4, IL10, LTA, TNFSF13B
19neonatal myasthenia gravis10.9
20juvenile myasthenia gravis10.8
21lambert-eaton myasthenic syndrome10.8
22pemphigus10.7
23thymic hyperplasia10.7
24transient neonatal myasthenia gravis10.7
25lupus erythematosus10.7
26thyroiditis10.7
27acquired myasthenia gravis10.6
28pemphigus foliaceus10.6
29ophthalmoplegia10.6
30polyneuropathy10.6
31lambert syndrome10.6
32fetal akinesia deformation sequence10.5RAPSN
33rippling muscle disease10.5
34myasthenia gravis with thymus hyperplasia10.5
35pure red-cell aplasia10.5
36muscular dystrophy10.5
37endplate acetylcholinesterase deficiency10.5ACHE
38alopecia10.5
39demyelinating polyneuropathy10.5
40encephalitis10.5
41mediastinitis10.5
42myocarditis10.5
43myositis10.5
44rippling muscle disease with myasthenia gravis10.5
45chronic inflammatory demyelinating polyneuropathy10.5
46neuromyelitis optica10.5
47internuclear ophthalmoplegia10.5
48cervicitis10.5
49hypothyroidism10.5
50castleman's disease10.5

Graphical network of the top 20 diseases related to Myasthenia Gravis:



Diseases related to myasthenia gravis

Symptoms for Myasthenia Gravis

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Drugs & Therapeutics for Myasthenia Gravis

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Drug clinical trials:

Search ClinicalTrials for Myasthenia Gravis

Search NIH Clinical Center for Myasthenia Gravis

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Hematopoietic stem cells for refractory myasthenia gravis
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Myasthenia Gravis

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Genetic tests related to Myasthenia Gravis:

id Genetic test Affiliating Genes
1 Myasthenia Gravis22

Anatomical Context for Myasthenia Gravis

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MalaCards organs/tissues related to Myasthenia Gravis:

31
Eye, Thymus, Skeletal muscle, T cells, B cells, Thyroid, Testes, Bone, Bone marrow, Heart, Lung, Neutrophil, Spleen, Brain, Kidney, Breast, Uterus, Prostate, Monocytes, Tongue, Pituitary

Animal Models for Myasthenia Gravis or affiliated genes

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Publications for Myasthenia Gravis

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Articles related to Myasthenia Gravis:

(show top 50)    (show all 1251)
idTitleAuthorsYear
1
Delivery of an miR155 inhibitor by anti-CD20 single chain antibody into B cells reduces the AChR-specific auto-antibodies and ameliorates experimental autoimmune myasthenia gravis. (24387321)
2014
2
Serum high mobility group box 1 is upregulated in myasthenia gravis. (25344065)
2014
3
Complete stable remission and autoantibody specificity in myasthenia gravis. (23255823)
2013
4
Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus. (22840813)
2013
5
Thymic tumours associated with Myasthenia gravis: a long term observation study of operated patients. (23944622)
2013
6
Leg pain in a patient with myasthenia gravis. (23613264)
2013
7
Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis. (23184497)
2013
8
Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: A population-based cohort study. (24332676)
2013
9
Tuberculosis in myasthenia gravis. (23232007)
2013
10
Myasthenia gravis developing in an HIV-negative patient with Kaposi's sarcoma. (23010878)
2013
11
Surgical treatment of myasthenia gravis: evident benefits and insidious pitfalls of mini-invasive techniques. (24088481)
2013
12
Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase. (23535158)
2013
13
Chronic urticaria in myasthenia gravis patients - More than occasional coexistence? (23972403)
2013
14
An ocular form of myasthenia gravis with a high titer of anti-MuSK antibodies during a long-term follow-up. (23124154)
2012
15
Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. (22367834)
2012
16
Clinical significance of detection of antibodies to fetal and adult acetylcholine receptors in myasthenia gravis. (22961471)
2012
17
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
18
Unilateral extended thoracoscopic thymectomy for nontumoral myasthenia gravis--a new standard. (22920527)
2012
19
Patient registries: useful tools for clinical research in myasthenia gravis. (23252904)
2012
20
Low-dose glucocorticoid therapy complements the pituitary-adrenocortical system and reduces anxiety and insomnia in myasthenia gravis patients. (22240858)
2012
21
Mosaic caveolin-3 expression in acquired rippling muscle disease without evidence of myasthenia gravis or acetylcholine receptor autoantibodies. (21295981)
2011
22
Robotic thymectomy for myasthenia gravis. (22042404)
2011
23
Investigation for RAPSN and DOK-7 mutations in a cohort of seronegative myasthenia gravis patients. (21305573)
2011
24
Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis. (22316202)
2011
25
Thymoma: inter-relationships among World Health Organization histology, Masaoka staging and myasthenia gravis and their independent prognostic significance: a single-centre experience. (21093283)
2011
26
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
27
Juvenile myasthenia gravis. (19229875)
2009
28
Widely varying TNF-alpha levels in patients with myasthenia gravis. (19214380)
2009
29
ABCB1 polymorphisms may have a minor effect on ciclosporin blood concentrations in myasthenia gravis patients. (18717915)
2008
30
Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis. (17255332)
2007
31
Effect of sera from AChR-antibody negative myasthenia gravis patients on AChR and MuSK in cell cultures. (17335909)
2007
32
Acquired von Willebrand's syndrome in a patient with severe primary hypothyroidism associated with myasthenia gravis in the course of autoimmune polyglandular syndrome type 3. (17880463)
2007
33
Dandy-Walker syndrome in adult mimicking myasthenia gravis. (17420852)
2007
34
Myasthenia gravis masquerading as post-poliomyelitis syndrome. (16546772)
2006
35
Seronegative neonatal myasthenia gravis in one of the twins. (15475637)
2004
36
Acquired rippling muscle disease with myasthenia gravis. (14694511)
2004
37
Seronegative myasthenia gravis]. (15034472)
2004
38
Myasthenia gravis in individuals over 40. (14592910)
2003
39
Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis. (12707978)
2003
40
Stiff person syndrome and myasthenia gravis. (11960163)
2002
41
Major review: the clinical spectrum of pediatric myasthenia gravis: blepharoptosis, ophthalmoplegia and strabismus. A report of 14 cases. (12171588)
2002
42
Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. (11231638)
2001
43
Cell-mediated immune response against titin in myasthenia gravis: evidence for the involvement of Th1 and Th2 cells. (9467662)
1998
44
FcgammaRIIA and FcgammaRIIIB polymorphisms in myasthenia gravis. (9521619)
1998
45
Myasthenia gravis sera containing antiryanodine receptor antibodies inhibit binding of [3H]-ryanodine to sarcoplasmic reticulum. (9486861)
1998
46
A patient with a relapse of myasthenia gravis after a 13-year remission following successful treatment by mediastinal irradiation and corticosteroid therapy]. (7605688)
1995
47
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
48
A novel HLA-DR4 allele (DRB1*0414) in a patient with myasthenia gravis. (1481204)
1992
49
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
50
Letter: Neonatal myasthenia gravis. (4448549)
1974

Variations for Myasthenia Gravis

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Expression for genes affiliated with Myasthenia Gravis

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Search GEO for disease gene expression data for Myasthenia Gravis.

Pathways for genes affiliated with Myasthenia Gravis

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Pathways related to Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CHRNA1, CHRNG
29.8LTA, IL10
3
Show member pathways
9.6CHRNA1, CHRNG, ACHE
49.6RAPSN, CHRNA1, MUSK
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.4TNFRSF4, TNFSF13B
69.3IL10, LTA, TNFRSF4
7
Show member pathways
9.2RYR1, CHRNA1, LTA
8
Show member pathways
9.1CHRNA1, CHRNG, MUSK, RYR1
9
Show member pathways
9.0TNFSF13B, TNFRSF4, LTA
10
Show member pathways
8.9TNFSF13B, LTA, IL10, MUSK
118.8HLA-DQB1, FCGR2A, IL10
128.8FCGR2A, IL10, HLA-DQB1
13
Show member pathways
8.8FCGR2A, IL10, HLA-DQB1
14
Show member pathways
8.7LTA, TNFSF13B, IL10, TNFRSF4
158.7CTLA4, HLA-DQB1, TNFSF13B
16
Show member pathways
8.5TNFSF13B, TNFRSF4, MUSK, IL10, LTA
17
Show member pathways
8.5TNFRSF4, LTA, TNFSF13B, IL10, MUSK
18
Show member pathways
8.5TNFSF13B, MUSK, IL10, LTA, TNFRSF4
19
Show member pathways
8.2LTA, TNFSF13B, HLA-DQB1, TNFRSF4
20
Show member pathways
8.0LTA, IL10, CTLA4, HLA-DQB1, TNFSF13B

Compounds for genes affiliated with Myasthenia Gravis

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Compounds related to Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
1edrophonium43 1211.4MUSK, ACHE
2gallamine43 2811.3CHRNA1, ACHE
3glatiramer acetate43 1211.1IL10, CTLA4
4toxin-14310.1LTA, IL10
5galantamine43 49 1212.1ACHE, CHRNG, CHRNA1
6indoleamine4310.1CTLA4, IL10
7cyclosporine49 1211.0LTA, IL10
8natalizumab43 1211.0FCGR2A, IL10
9adalimumab43 49 1211.9IL10, FCGR2A
10nicotine43 28 49 1212.9CHRNA1, ACHE, MUSK
11blys439.9TNFSF13B, IL10
12okt3439.9LTA, IL10
13enterotoxin439.9CTLA4, LTA
14con a439.9IL10, CTLA4
15propionate439.8IL10, RYR1
16mycophenolate mofetil43 49 1211.8LTA, IL10, CTLA4
17il 10439.8IL10, LTA, CTLA4
18succinylcholine43 49 28 1212.8CHRNA1, RYR1, ACHE
19lipoteichoic acid439.8LTA, IL10
20ryanodine43 28 5911.7RYR1, TTN, MUSK
21tgf beta1439.7LTA, IL10, CTLA4
22etanercept43 49 1211.7FCGR2A, IL10, LTA
23ivig439.6LTA, FCGR2A, IL10
24prednisolone43 28 1211.6IL10, LTA, FCGR2A
25tacrolimus43 49 1211.6RYR1, IL10, CTLA4
26digoxin43 59 49 24 1213.6IL10, RYR1
27rantes439.6CTLA4, LTA, IL10
28ecori439.5HLA-DQB1, LTA
29potassium43 24 1211.4TTN, RAPSN, RYR1, MUSK
30vitamin d439.4LTA, CTLA4, IL10
31ionomycin439.4LTA, CTLA4, IL10, TNFRSF4
32infliximab43 49 1211.3CTLA4, LTA, FCGR2A, IL10
33cyclosporin a43 28 5911.3TNFRSF4, CTLA4, IL10, LTA
34rituximab43 49 1210.8MUSK, TNFSF13B, IL10, CTLA4, FCGR2A
35threonine438.5FCGR2A, TTN, CTLA4, LTA
36lipid438.5RAPSN, RYR1, LTA, CTLA4, MUSK, FCGR2A
37serine438.4LTA, ACHE, CTLA4, RYR1, TTN, FCGR2A
38glutamate438.1HLA-DQB1, TTN, ACHE, CTLA4, LTA, RYR1
39tyrosine438.1LTA, RAPSN, MUSK, HLA-DQB1, FCGR2A, CTLA4
40acetylcholine43 49 28 24 1212.1CHRNA1, RAPSN, CTLA4, LTA, RYR1, MUSK
41calcium43 49 24 1210.5TNFSF13B, RYR1, TTN, FCGR2A, MUSK, RAPSN

GO Terms for genes affiliated with Myasthenia Gravis

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Cellular components related to Myasthenia Gravis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00058929.9CHRNA1, CHRNG
2neuromuscular junctionGO:00315949.5MUSK, CHRNA1, ACHE, RAPSN
3I bandGO:00316749.3TTN, RYR1
4postsynaptic membraneGO:00452119.2MUSK, RAPSN, ACHE, CHRNG, CHRNA1
5cell junctionGO:00300549.2RAPSN, MUSK, ACHE, CHRNA1, CHRNG
6Golgi apparatusGO:00057949.2TTN, ACHE, RAPSN, CTLA4
7integral component of plasma membraneGO:00058878.5TNFRSF4, MUSK, CHRNG, CTLA4, RYR1
8plasma membraneGO:00058866.8TNFSF13B, FCGR2A, CHRNA1, CHRNG, ACHE, CTLA4

Biological processes related to Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:000727110.0RAPSN, ACHE
2negative regulation of B cell proliferationGO:003088910.0IL10, CTLA4
3negative regulation of growth of symbiont in hostGO:004413010.0IL10, LTA
4positive regulation of neuron apoptotic processGO:00435259.9RAPSN, MUSK
5negative regulation of T cell proliferationGO:00421309.8IL10, CTLA4
6neuromuscular junction developmentGO:00075289.8CHRNA1, MUSK
7regulation of protein kinase activityGO:00458599.7TTN, TNFRSF4
8muscle contractionGO:00069369.6RYR1, CHRNG, TTN
9synaptic transmissionGO:00072689.5RAPSN, ACHE, CHRNG, CHRNA1
10positive regulation of B cell proliferationGO:00308909.1TNFRSF4, TNFSF13B
11T cell costimulationGO:00312958.9CTLA4, TNFSF13B, HLA-DQB1
12immune responseGO:00069558.4HLA-DQB1, TNFSF13B, TNFRSF4, CTLA4

Molecular functions related to Myasthenia Gravis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine bindingGO:004216610.0ACHE, CHRNA1
2acetylcholine receptor activityGO:001546410.0CHRNG, CHRNA1
3acetylcholine-activated cation-selective channel activityGO:00048899.9CHRNG, CHRNA1
4protein self-associationGO:00436219.9ACHE, TTN
5tumor necrosis factor receptor bindingGO:00051649.1LTA, TNFSF13B
6cytokine activityGO:00051259.1TNFSF13B, IL10, LTA

Products for genes affiliated with Myasthenia Gravis

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Sources for Myasthenia Gravis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet