MG
MCID: MYS003
MIFTS: 79

Myasthenia Gravis (MG) malady

Neuronal diseases category

Summaries for Myasthenia Gravis

About this section
Sources:
42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest.. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke

MalaCards: Myasthenia Gravis, also known as myasthenia gravis without exacerbation, is related to thymoma and lambert-eaton myasthenic syndrome. An important gene associated with Myasthenia Gravis is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The drugs cyclophosphamide and cyclosporine and the compounds tyrosine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include eye, skeletal muscle and thymus, and related mouse phenotypes are mortality/aging and respiratory system.

NIH Rare Diseases:42 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. last updated: 3/11/2009

NINDS:43 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.

Genetics Home Reference:21 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.

Wikipedia:63 Myasthenia gravis (from Greek μύς \"muscle\", ἀσθένεια \"weakness\", and Latin: gravis... more...

Description from OMIM:46 254200,159400,607085

Aliases & Classifications for Myasthenia Gravis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
myasthenia gravis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

myasthenia gravis 8 42 22 21 43 10 44 48 46 33 30 60
myasthenia gravis without exacerbation 8
myasthenia gravis with exacerbation 8
autoimmune myasthenia gravis 48
myasthenia gravis nos 8
acquired myasthenia 48
mg 21


External Ids:

Disease Ontology8 DOID:437
MeSH34 D009157
NCIt39 C60989
ICD9CM27 358.0
MESH via Orphanet35 D009157
ICD10 via Orphanet26 G70.0
SNOMED-CT via Orphanet57 91637004
UMLS via Orphanet61 C0026896

Related Diseases for Myasthenia Gravis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Myasthenia Gravis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.7IL2, MUSK, AIRE, CTLA4, TNFRSF4, RYR1
2lambert-eaton myasthenic syndrome31.1MUSK
3thyroiditis30.9CTLA4
4systemic lupus erythematosus30.8FCGR2A, TNFSF13B
5polyneuropathy30.7ACHE
6multiple sclerosis30.7TNFSF13B, CTLA4, HLA-DQB1, LTA, CD80, IL10
7graves' disease30.7TNFRSF4, CTLA4, HLA-DQB1, AIRE, LTA, CD80
8hypothyroidism30.6AIRE, CTLA4
9myositis30.6TTN, RYR1
10alopecia30.6AIRE
11myopathy30.5RYR1, TTN, RAPSN, ACHE
12autoimmune thyroiditis30.5CD80, AIRE, CTLA4
13leukemia30.4TNFRSF4, LTA, MUSK, CD80, IL2, ACHE
14respiratory failure30.4TTN, RYR1, MUSK
15congenital myasthenic syndrome30.4CHRNA1, MUSK, RAPSN
16hepatitis30.4LTA, AIRE, CTLA4
17alopecia areata30.4AIRE
18glomerulonephritis30.4FCGR2A
19neuromuscular disease30.4TTN, RYR1, MUSK
20lung cancer30.4IL2
21rheumatoid arthritis30.3TNFSF13B, TNFRSF4, CTLA4, HLA-DQB1, LTA, CD80
22asthma30.3TNFSF13B, TNFRSF4, CTLA4, CD80, IL10
23arthritis30.3CTLA4, LTA, CD80, IL10, FCGR2A
24neuropathy30.3RAPSN, TTN, RYR1
25diabetes mellitus30.3AIRE, HLA-DQB1, CTLA4
26hepatitis c30.3TNFSF13B, CTLA4, IL10, IL2
27vitiligo30.3CTLA4, AIRE
28uveitis30.3CTLA4, LTA, IL10
29addison's disease30.3AIRE, CTLA4
30dermatitis30.3CTLA4
31candidiasis30.3AIRE
32connective tissue disease30.3IL2, IL10, CTLA4
33meningitis30.3FCGR2A
34breast cancer30.3CTLA4, CD80, IL2
35myeloid leukemia30.1LTA
36encephalomyelitis30.1TNFSF13B, TNFRSF4, CTLA4, HLA-DQB1, LTA, CD80
37tetanus30.1LTA, CD80, IL10, IL2, ACHE
38lepromatous leprosy30.1LTA, IL10, IL2
39melanoma30.1FCGR2A, IL2, IL10, CD80, CTLA4, TNFRSF4
40tuberculosis30.1IL2, IL10, HLA-DQB1
41myeloma30.1TNFSF13B, LTA, CD80, IL2
42leprosy30.1IL2
43optic neuritis30.1LTA
44chronic mucocutaneous candidiasis30.1IL10, AIRE
45pancreatitis30.1IL10
46autoimmune hepatitis30.1AIRE, HLA-DQB1, CTLA4
47colorectal cancer30.1IL2, CD80
48achalasia30.1ACHE
49primary biliary cirrhosis30.1CTLA4, AIRE, LTA
50thrombocytopenia30.1FCGR2A, IL2

Graphical network of the top 20 diseases related to Myasthenia Gravis:



Diseases related to myasthenia gravis

Clinical Features for Myasthenia Gravis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

254200,159400,607085

Clinical synopsis from OMIM:

159400

Drugs & Therapeutics for Myasthenia Gravis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myasthenia Gravis

Drug clinical trials:

Search ClinicalTrials for Myasthenia Gravis

Search NIH Clinical Center for Myasthenia Gravis

Search CenterWatch for Myasthenia Gravis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Hematopoietic stem cells for refractory myasthenia gravis
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Myasthenia Gravis

About this section
Sources:
22GTR
See all sources

Genetic tests related to Myasthenia Gravis:

id Genetic test Affiliating Genes
1 Myasthenia Gravis22

Anatomical Context for Myasthenia Gravis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Myasthenia Gravis:

32
Eye, Skeletal muscle, Thymus, T cells, B cells, Thyroid, Testes, Bone, Bone marrow, Lung, Heart, Breast, Uterus, Prostate, Kidney, Monocytes, Brain, Spleen, Tongue, Pituitary

Animal Models for Myasthenia Gravis or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Myasthenia Gravis

About this section
Sources:
50PubMed
See all sources

Articles related to Myasthenia Gravis:

(show top 50)    (show all 1196)
idTitleAuthorsYear
1
Molecular docking cannot accurately predict drug off-target effects: Implications for the role of voriconazole in the exacerbation of myasthenia gravis. (24127354)
2014
2
One-minute exercise is best for evaluation of post-exercise exhaustion in myasthenia gravis. (24435816)
2014
3
Statins can induce myasthenia gravis. (24433954)
2014
4
Myasthenia gravis and thymoma coexisting with myotonic dystrophy type 1. (24291332)
2014
5
Myasthenia gravis: A comprehensive review of immune dysregulation and etiological mechanisms. (24389034)
2014
6
T cell repertoire in DQ5-positive MuSK-positive myasthenia gravis patients. (24397960)
2014
7
Collagen Q is a Key Player for Developing Rational Therapy for Congenital Myasthenia and for Dissecting the Mechanisms of Anti-MuSK Myasthenia Gravis. (24234034)
2013
8
Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis. (23791150)
2013
9
Nephrotic syndrome after thymectomy for myasthenia gravis. (23580814)
2013
10
Jitter analysis with concentric needle electrode in the masseter muscle for the diagnosis of generalised myasthenia gravis. (23849701)
2013
11
Chronic myelomonocytic leukemia associated with generalized myasthenia gravis. (24050508)
2013
12
Severe asthma associated with myasthenia gravis. (24032123)
2013
13
Complement C2 siRNA mediated therapy of myasthenia gravis in mice. (23410585)
2013
14
The effect of early prednisolone treatment on the generalization rate in ocular myasthenia gravis. (23279780)
2013
15
Effect of sera from seronegative myasthenia gravis patients on neuromuscular junctions. (23389808)
2013
16
Clinical features of myasthenia gravis patients with autoimmune thyroid disease in Taiwan. (22725712)
2013
17
Possible involvement of toll-like receptors in the pathogenesis of myasthenia gravis. (22898741)
2013
18
Heart rate and blood pressure variability in patients with myasthenia gravis. (24101810)
2013
19
Non-coronary myocardial infarction in myasthenia gravis: Case report and review of the literature. (23888198)
2013
20
Clinical significance of detection of antibodies to fetal and adult acetylcholine receptors in myasthenia gravis. (22961471)
2012
21
Assessment of health-related quality of life in patients with myasthenia gravis in Belgrade (Serbia). (22875151)
2012
22
Novel animal models of acetylcholine receptor antibody-related myasthenia gravis. (23252908)
2012
23
Neuromuscular block reversal with sugammadex in a morbidly obese patient with myasthenia gravis. (23801510)
2012
24
Thymectomy for thymoma and myasthenia gravis. A survey of current surgical practice in thymic disease amongst EACTS members. (22374292)
2012
25
Treatment strategies for myasthenia gravis: an update. (22775575)
2012
26
Myasthenia gravis in the elderly: a rare cause of undernutrition. (23238315)
2012
27
Acute presentation of autoimmune hepatitis in a patient with myasthenia gravis, thymoma, Hashimoto thyroiditis and connective tissue disorder. (22776553)
2012
28
Opportunistic infections in myasthenia gravis treated with mycophenolate mofetil. (22613699)
2012
29
Ectopic thymic tissue in the mediastinum: limitations for the operative treatment of myasthenia gravis. (22362621)
2012
30
Management challenges in muscle-specific tyrosine kinase myasthenia gravis. (23252901)
2012
31
Severe, focal tibialis anterior and triceps brachii weakness in myasthenia gravis: a case report. (22361519)
2011
32
Candida esophagitis as the cause of swallowing disturbances in an 85-year-old patient with myasthenia gravis. (21732154)
2011
33
Transient neonatal myasthenia gravis revealing a myasthenia gravis and a systemic lupus erythematosus in the mother: case report and review of the literature. (19488958)
2010
34
The autoimmunity-related polymorphism PTPN22 1858C/T is associated with anti-titin antibody-positive myasthenia gravis. (19406179)
2009
35
Electroacupuncture warming therapy combined with western medicine for treatment of myasthenia gravis and effect on IL-4 level in the patients]. (18271233)
2007
36
Myasthenia gravis accompanied with hypokalemic periodic paralysis. (16756062)
2006
37
Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis. (16182377)
2005
38
Anti-MuSK myasthenia gravis presenting with purely ocular findings. (15956173)
2005
39
Acquired rippling muscle disease with myasthenia gravis. (14694511)
2004
40
The significance of titin antibodies in myasthenia gravis--correlation with thymoma and severity of myasthenia gravis. (15316806)
2004
41
HLA class II genotypes in Mexican Mestizo patients with myasthenia gravis. (14641517)
2003
42
Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. (11026443)
2000
43
Plasmapheresis in myasthenia gravis. A comparative study of daily versus alternately daily schedule. (10100957)
1999
44
A case of myasthenia gravis in childhood associated with chronic inflammatory demyelinating polyradiculoneuropathy. (9638666)
1998
45
Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis. (8688498)
1995
46
Interleukin-2 Pseudomonas exotoxin chimeric protein is cytotoxic to B cell cultures derived from myasthenia gravis patients. (8583224)
1995
47
Ryanodine receptor antibodies related to severity of thymoma associated myasthenia gravis. (8021674)
1994
48
Exotropia as a sign of myasthenia gravis in dysthyroid ophthalmopathy. (8110684)
1993
49
Lambert-Eaton myasthenic syndrome associated with hypothyroidism and features of myasthenia gravis. (3612084)
1987
50
Myasthenia gravis, pernicious anemia, and Hashimoto's thyroiditis. (582504)
1979

Genetic Variations for Myasthenia Gravis

About this section

Expression for genes affiliated with Myasthenia Gravis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myasthenia Gravis

Search GEO for disease gene expression data for Myasthenia Gravis.

Pathways for genes affiliated with Myasthenia Gravis

About this section
Sources:
51QIAGEN, 29KEGG, 55SinoBiological, 52R&D Systems, 37NCBI BioSystems Database, 53Reactome
See all sources

Pathways related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8TNFSF13B, TNFRSF4, LTA, MUSK, CD80, IL10
2
Hide members
10.8IL2, IL10, CD80, MUSK, LTA, TNFSF13B
3
Hide members
10.8IL10, CD80, LTA, HLA-DQB1, CTLA4, TNFSF13B
4
Hide members
10.7CHRNG, CHRNA1, MUSK, IL2, RYR1
5
Hide members
10.7FCGR2A, IL2, CD80, MUSK, HLA-DQB1
6
Hide members
10.7TNFRSF4, LTA, MUSK, CD80
7
Hide members
10.7LTA, HLA-DQB1, TNFRSF4, TNFSF13B
8
Hide members
10.7TNFSF13B, TNFRSF4, MUSK, CD80
910.7TNFSF13B, CTLA4, HLA-DQB1, CD80
10
Hide members
10.7TNFSF13B, TNFRSF4, LTA, CD80
1110.7TNFRSF4, LTA, IL10, IL2
12
Hide members
10.7HLA-DQB1, IL10, IL2, FCGR2A
13
Hide members
10.7IL2, CD80, HLA-DQB1, CTLA4
14
Hide members
10.7FCGR2A, IL10, CD80, HLA-DQB1
15
Hide members
10.7LTA, CD80, IL10, IL2
1610.6RAPSN, MUSK, CHRNA1
1710.6FCGR2A, IL2, TNFSF13B
1810.6HLA-DQB1, IL10, FCGR2A
1910.6LTA, IL10, IL2
20
Hide members
10.6CTLA4, HLA-DQB1, CD80
21
Hide members
10.6CHRNA1, CHRNG

Compounds for genes affiliated with Myasthenia Gravis

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.3CTLA4, HLA-DQB1, AKAP12, AIRE, LTA, MUSK
2acetylcholine44 49 28 11 2415.3CTLA4, CHRNA1, LTA, MUSK, RYR1, TTN
3rituximab44 49 1113.2FCGR2A, TNFSF13B, CTLA4, MUSK, CD80, IL10
4calcium44 49 11 2414.2TNFSF13B, CTLA4, LTA, MUSK, CD80, RYR1
5ionomycin4411.2TNFRSF4, CTLA4, LTA, CD80, IL10, IL2
6cyclosporin a44 28 5913.1IL2, IL10, CD80, LTA, CTLA4, TNFRSF4
7serine4411.1ACHE, FCGR2A, TTN, RYR1, LTA, CTLA4
8rapamycin4411.1RYR1, IL2, IL10, CD80, CTLA4
9il 104411.1CTLA4, LTA, IL10, IL2
10prednisolone44 28 1113.0FCGR2A, IL2, IL10, LTA
11succinylcholine44 28 1113.0ACHE, RYR1, CHRNA1
12ctla4-ig4411.0IL2, CD80, CTLA4
13galantamine44 49 1113.0ACHE, CHRNA1, CHRNG
14toxin-14411.0LTA, IL10, IL2
15glatiramer acetate44 1112.0CTLA4, IL10, IL2
16enterotoxin4411.0CTLA4, LTA, CD80
17okt34411.0LTA, IL10, IL2
18con a4411.0IL2, IL10, CTLA4
19tacrolimus44 49 1113.0CTLA4, IL10, IL2, RYR1
20etanercept44 49 1113.0LTA, IL10, FCGR2A
21edrophonium44 1111.9ACHE, MUSK
22mycophenolate mofetil44 49 1112.9CTLA4, IL10, IL2
23belatacept44 1111.9CD80, CTLA4
24infliximab44 49 1112.9IL10, LTA, CTLA4
25gallamine44 2811.9ACHE, CHRNA1
26ivig4410.9FCGR2A, IL10, LTA
27abatacept44 1111.9CD80, CTLA4
28glutamate4410.8RYR1, TTN, ACHE
29ryanodine44 28 5912.8TTN, RYR1, MUSK
30pentoxifylline44 1111.8LTA
31neopterin4410.8LTA, IL10, IL2
32interferon gamma4410.7IL2, IL10
33rantes4410.7IL2, LTA
34allergens4410.7IL10, CD80, CTLA4
35daclizumab44 1111.6FCGR2A, IL2
36alpha-galactosylceramide4410.6IL10, IL2
37thalidomide44 49 59 1113.5IL2, IL10, CTLA4
38blys4410.3IL10, TNFSF13B

GO Terms for genes affiliated with Myasthenia Gravis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.9TNFSF13B, CTLA4, HLA-DQB1, AKAP12, CHRNG, CHRNA1
2neuromuscular junctionGO:03159410.7ACHE, RAPSN, MUSK, CHRNA1
3postsynaptic membraneGO:04521110.7CHRNG, CHRNA1, MUSK, RAPSN, ACHE
4acetylcholine-gated channel complexGO:00589210.6CHRNA1, CHRNG
5cell junctionGO:03005410.4CHRNG, CHRNA1, MUSK, RAPSN, ACHE

Biological processes related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.0IL2, AIRE, HLA-DQB1, CTLA4, TNFRSF4, TNFSF13B
2T cell costimulationGO:03129510.9TNFSF13B, CTLA4, HLA-DQB1, CD80
3positive regulation of B cell proliferationGO:03089010.8IL2, TNFRSF4, TNFSF13B
4cell-cell signalingGO:00726710.8LTA, CD80, IL10, IL2
5positive regulation of immunoglobulin secretionGO:05102410.7IL2, TNFRSF4
6muscle contractionGO:00693610.7TTN, RYR1, CHRNG
7regulation of protein kinase activityGO:04585910.6TTN, TNFRSF4
8negative regulation of B cell proliferationGO:03088910.6CTLA4, IL10
9synaptic transmission, cholinergicGO:00727110.5ACHE, RAPSN
10negative regulation of growth of symbiont in hostGO:04413010.3IL10, LTA

Molecular functions related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL2, IL10, LTA, TNFSF13B
2acetylcholine-activated cation-selective channel activityGO:00488910.6CHRNA1, CHRNG
3acetylcholine bindingGO:04216610.5CHRNA1, ACHE
4acetylcholine receptor activityGO:01546410.3CHRNA1, CHRNG

Products for genes affiliated with Myasthenia Gravis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myasthenia Gravis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet