MG
MCID: MYS003
MIFTS: 71

Myasthenia Gravis (MG) malady

Neuronal category

Summaries for Myasthenia Gravis

Sources:
43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest.. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke

MalaCards: Myasthenia Gravis, also known as myasthenia gravis without exacerbation, is related to thymoma and lambert-eaton myasthenic syndrome. An important gene associated with Myasthenia Gravis is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The drugs cyclophosphamide and cyclosporine and the compounds tyrosine and acetylcholine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and respiratory system.

NIH Rare Diseases:43 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. last updated: 3/11/2009

NINDS:44 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.

Genetics Home Reference:21 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.

Wikipedia:64 Myasthenia gravis (from Greek μύς \"muscle\", ἀσθένεια \"weakness\", and Latin: gravis... more...

Description from OMIM:47 254200,159400,607085

Aliases & Classifications for Myasthenia Gravis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
myasthenia gravis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

myasthenia gravis 8 43 22 21 44 10 45 49 47 34 31 61
myasthenia gravis without exacerbation 8
myasthenia gravis with exacerbation 8
autoimmune myasthenia gravis 49
myasthenia gravis nos 8
acquired myasthenia 49
mg 21


External Ids:

Disease Ontology8 DOID:437
MeSH35 D009157
NCIt40 C60989
ICD9CM27 358.0
MESH via Orphanet36 D009157
ICD10 via Orphanet26 G70.0
SNOMED-CT via Orphanet58 91637004
UMLS via Orphanet62 C0026896

Related Diseases for Myasthenia Gravis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Myasthenia Gravis family:

myasthenia gravis congenital myasthenia gravis with thymus hyperplasia

Diseases related to Myasthenia Gravis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 455)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.7IL2, MUSK, AIRE, CTLA4, TTN, RYR1
2lambert-eaton myasthenic syndrome31.2MUSK
3systemic lupus erythematosus30.9FCGR2A, TNFSF13B
4graves' disease30.7CD80, AIRE, TNFRSF4, CTLA4, HLA-DQB1, LTA
5alopecia30.6AIRE
6polymyositis30.6CTLA4, CD80, TTN
7thyroiditis30.6CTLA4
8hepatitis c30.5IL10, TNFSF13B, CTLA4, IL2
9congenital myasthenic syndrome30.5RAPSN, MUSK, CHRNA1
10alopecia areata30.5AIRE
11asthma30.3IL10, TNFSF13B, CD80, TNFRSF4, CTLA4
12arthritis30.3CD80, LTA, IL10, CTLA4, FCGR2A
13vitiligo30.3AIRE, CTLA4
14uveitis30.3CTLA4, IL10, LTA
15pemphigus vulgaris30.3TNFSF13B
16tetanus30.1LTA, CD80, IL10, IL2, ACHE
17lepromatous leprosy30.1LTA, IL2, IL10
18tuberculosis30.1HLA-DQB1, IL10, IL2
19chronic mucocutaneous candidiasis30.1AIRE, IL10
20autoimmune hepatitis30.1CTLA4, HLA-DQB1, AIRE
21hepatitis b30.1IL10, HLA-DQB1, CTLA4
22colorectal cancer30.1CD80, IL2
23autoimmune thyroiditis30.1AIRE, CTLA4, CD80
24achalasia30.1ACHE
25primary biliary cirrhosis30.1CTLA4, AIRE, LTA
26thrombocytopenia30.1IL2, FCGR2A
27visceral leishmaniasis30.0IL10, LTA
28allergic rhinitis29.9IL10, CTLA4
29osteoarthritis29.9CTLA4, LTA, CD80
30tonsillitis29.9LTA
31nodular goiter29.7CD80, CTLA4, TNFRSF4
32adenocarcinoma29.7CD80
33arthropathy29.7CTLA4
34deficiency anemia29.7FCGR2A, IL2
35atherosclerosis29.7FCGR2A, IL10
36neonatal myasthenia gravis10.9
37lambert syndrome10.8
38pemphigus10.7
39thymic hyperplasia10.7
40n syndrome10.6
41myasthenia gravis congenital10.6
42guillain-barr� syndrome10.6
43myasthenia gravis, neonatal transient10.6
44pemphigus foliaceus10.5
45astrocytoma10.5
46rippling muscle disease10.5
47hypercholesterolemia10.5
48neuromyelitis optica10.4
49internuclear ophthalmoplegia10.4
50facioscapulohumeral muscular dystrophy10.4

Graphical network of the top 20 diseases related to Myasthenia Gravis:



Diseases related to myasthenia gravis

Clinical Features for Myasthenia Gravis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

254200,159400,607085

Clinical synopsis from OMIM:

159400

Drugs & Therapeutics for Myasthenia Gravis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myasthenia Gravis

Drug clinical trials:

Search ClinicalTrials for Myasthenia Gravis

Search NIH Clinical Center for Myasthenia Gravis

Search CenterWatch for Myasthenia Gravis

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Hematopoietic stem cells for refractory myasthenia gravis
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Myasthenia Gravis

Sources:
22GTR
See all sources

Genetic tests related to Myasthenia Gravis:

id Genetic test Affiliating Genes
1 Myasthenia Gravis22

Anatomical Context for Myasthenia Gravis

Animal Models for Myasthenia Gravis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myasthenia Gravis

Sources:
51PubMed
See all sources

Articles related to Myasthenia Gravis:

(show top 50)    (show all 1196)
idTitleAuthorsYear
1
Tuberculosis in myasthenia gravis. (23232007)
2013
2
Analysis of outcomes following surgical treatment of thymolipomatous myasthenia gravis: comparison with thymomatous and non-thymomatous myasthenia gravis. (24366316)
2013
3
Management of juvenile myasthenia gravis. (23337001)
2013
4
Maintenance IVIg therapy in myasthenia gravis does not affect disease activity. (24267740)
2013
5
Myasthenia gravis, Castleman disease, pemphigus, and anti-phospholipid syndrome. (23386221)
2013
6
Myasthenia gravis: Predictive factors associated with the synchronized elevation of anti-acetylcholine receptor antibody titer in Kanazawa, Japan. (24388223)
2013
7
Changes in regulatory T cells after rituximab in two patients with refractory myasthenia gravis. (23749295)
2013
8
Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis. (23454161)
2013
9
I^-glucans reduce LDL cholesterol in patients with myasthenia gravis. (23187951)
2013
10
Antioxidant status of bilirubin and uric acid in patients with myasthenia gravis. (22067621)
2012
11
Epidemiology of myasthenia gravis in Austria: rising prevalence in an ageing society. (23129486)
2012
12
IVIG and PLEX in the treatment of myasthenia gravis. (23278570)
2012
13
The role of B cell-activating factor in autoimmune myasthenia gravis. (23252898)
2012
14
Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis. (22167224)
2012
15
A retrospective review of 15 patients with familial myasthenia gravis over a period of 25 years. (22057263)
2012
16
Delayed presentation of invasive thymoma in myasthenia gravis: a case report. (21296574)
2011
17
Trismus as a first presenting complaint in a case of myasthenia gravis. (22406724)
2011
18
Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis. (20728226)
2010
19
Socioeconomic burden of amyotrophic lateral sclerosis, myasthenia gravis and facioscapulohumeral muscular dystrophy. (19629566)
2010
20
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
21
Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis. (18088253)
2008
22
Isolated facial and bulbar paresis: a persistent manifestation of neonatal myasthenia gravis. (18195270)
2008
23
Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase. (17698793)
2007
24
Acquired generalised neuromyotonia, cutaneous lupus erythematosus and alopecia areata in a patient with myasthenia gravis. (17239529)
2007
25
Anti-MuSK-positive myasthenia gravis: neuromuscular transmission failure in facial and limb muscles. (17212617)
2007
26
Myasthenia gravis masquerading as post-poliomyelitis syndrome. (16546772)
2006
27
Titin and ryanodine receptor antibodies in myasthenia gravis. (16637922)
2006
28
Clinical value of the immune parameters in patients with myasthenia gravis]. (17313828)
2006
29
A CTLA4high genotype is associated with myasthenia gravis in thymoma patients. (16178018)
2005
30
Striational antibodies in myasthenia gravis: reactivity and possible clinical significance. (15767509)
2005
31
Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis. (16150851)
2005
32
Structural and ultrastructural localization of NGF and NGF receptors in the thymus of subjects affected by myasthenia gravis. (15763921)
2004
33
Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man. (12935778)
2003
34
The relationship between abnormal apoptosis and Fas expression of thymocytes from patients with myasthenia gravis]. (15169653)
2003
35
T cells and cytokines in the pathogenesis of acquired myasthenia gravis. (14592887)
2003
36
Antiphospholipid syndrome and multiple ischemic strokes in a patient with myasthenia gravis. (12652972)
2002
37
Myasthenia gravis: diagnostic and management dilemmas. (11562569)
2001
38
Tensilon and the diagnosis of myasthenia gravis: are we using the Tensilon test too much? (12803671)
2001
39
Tumor necrosis factor receptor-1 is critically involved in the development of experimental autoimmune myasthenia gravis. (11007755)
2000
40
Myasthenia gravis with alopecia totalis. (9583214)
1998
41
Engraftment of myasthenia gravis thymocytes into severe combined immunodeficiency (SCID) mice. (9892503)
1998
42
Cellular mRNA expression of interferon-gamma (IFN-gamma), IL-4 and IL-10 relates to resistance to experimental autoimmune myasthenia gravis (EAMG) in young Lewis rats. (9182902)
1997
43
Failure to down-regulate Bcl-2 protein in thymic germinal center B cells in myasthenia gravis. (9130628)
1997
44
Suppression of experimental autoimmune myasthenia gravis and experimental allergic encephalomyelitis by oral administration of acetylcholine receptor and myelin basic protein: double tolerance. (8557828)
1995
45
Aseptic meningitis as complication of intravenous immunoglobulin therapy for myasthenia gravis. (8380010)
1993
46
T-cell immunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis. (7683442)
1993
47
Neonatal myasthenia gravis: specific advantages of repetitive stimulation over edrophonium testing. (3242526)
1988
48
Neonatal myasthenia gravis. Anti-acetylcholine receptor antibodies in the amniotic fluid. (6746895)
1984
49
Prolonged neonatal myasthenia gravis: electrophysiological studies. (727721)
1978
50
Autoimmunity in concurrent myasthenia gravis and pemphigus erythematosus. (4865768)
1968

Genetic Variations for Myasthenia Gravis

Expression for genes affiliated with Myasthenia Gravis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myasthenia Gravis

Search GEO for disease gene expression data for Myasthenia Gravis.

Pathways for genes affiliated with Myasthenia Gravis

Sources:
52QIAGEN, 30KEGG, 56SinoBiological, 53R&D Systems, 38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8LTA, TNFSF13B, MUSK, CD80, IL10, TNFRSF4
2
Hide members
10.8TNFSF13B, CD80, IL2, IL10, MUSK, LTA
3
Hide members
10.8TNFSF13B, CD80, LTA, HLA-DQB1, IL10, CTLA4
4
Hide members
10.7MUSK, CHRNA1, RYR1, IL2, CHRNG
5
Hide members
10.7CD80, IL2, MUSK, HLA-DQB1, FCGR2A
6
Hide members
10.7CD80, TNFRSF4, MUSK, LTA
7
Hide members
10.7TNFSF13B, LTA, HLA-DQB1, TNFRSF4
8
Hide members
10.7CD80, TNFRSF4, TNFSF13B, MUSK
910.7CD80, HLA-DQB1, CTLA4, TNFSF13B
10
Hide members
10.7TNFRSF4, TNFSF13B, CD80, LTA
1110.7IL2, TNFRSF4, LTA, IL10
12
Hide members
10.7FCGR2A, IL2, HLA-DQB1, IL10
13
Hide members
10.7CD80, CTLA4, IL2, HLA-DQB1
14
Hide members
10.7FCGR2A, IL10, CD80, HLA-DQB1
15
Hide members
10.7IL2, IL10, LTA, CD80
1610.6MUSK, RAPSN, CHRNA1
1710.6TNFSF13B, FCGR2A, IL2
1810.6HLA-DQB1, FCGR2A, IL10
1910.6IL10, LTA, IL2
20
Hide members
10.6HLA-DQB1, CTLA4, CD80
21
Hide members
10.6CHRNA1, CHRNG

Compounds for genes affiliated with Myasthenia Gravis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.3LTA, CD80, FCGR2A, RAPSN, IL2, MUSK
2acetylcholine45 50 29 11 2415.3RAPSN, TTN, RYR1, MUSK, LTA, ACHE
3rituximab45 50 1113.2IL2, FCGR2A, TNFSF13B, CTLA4, MUSK, CD80
4calcium45 50 11 2414.2MUSK, LTA, RAPSN, TNFSF13B, RYR1, FCGR2A
5ionomycin4511.2TNFRSF4, CTLA4, IL2, LTA, CD80, IL10
6cyclosporin a45 29 6013.1IL2, TNFRSF4, CTLA4, LTA, CD80, IL10
7serine4511.1TTN, LTA, RYR1, FCGR2A, ACHE, CTLA4
8rapamycin4511.1RYR1, IL2, IL10, CD80, CTLA4
9il 104511.1LTA, IL10, IL2, CTLA4
10prednisolone45 29 1113.0IL2, FCGR2A, LTA, IL10
11succinylcholine45 29 1113.0CHRNA1, RYR1, ACHE
12ctla4-ig4511.0CTLA4, CD80, IL2
13galantamine45 50 1113.0CHRNG, ACHE, CHRNA1
14toxin-14511.0LTA, IL10, IL2
15glatiramer acetate45 1112.0CTLA4, IL2, IL10
16enterotoxin4511.0CD80, LTA, CTLA4
17okt34511.0LTA, IL10, IL2
18con a4511.0IL2, IL10, CTLA4
19tacrolimus45 50 1113.0CTLA4, IL2, IL10, RYR1
20etanercept45 50 1113.0LTA, IL10, FCGR2A
21edrophonium45 1111.9MUSK, ACHE
22mycophenolate mofetil45 50 1112.9CTLA4, IL10, IL2
23belatacept45 1111.9CTLA4, CD80
24infliximab45 50 1112.9IL10, LTA, CTLA4
25gallamine45 2911.9CHRNA1, ACHE
26ivig4510.9LTA, IL10, FCGR2A
27abatacept45 1111.9CTLA4, CD80
28glutamate4510.8ACHE, TTN, RYR1
29ryanodine45 29 6012.8RYR1, MUSK, TTN
30pentoxifylline45 1111.8LTA
31neopterin4510.8LTA, IL2, IL10
32interferon gamma4510.7IL10, IL2
33rantes4510.7IL2, LTA
34allergens4510.7IL10, CD80, CTLA4
35daclizumab45 1111.6FCGR2A, IL2
36alpha-galactosylceramide4510.6IL2, IL10
37thalidomide45 50 60 1113.5IL2, IL10, CTLA4
38blys4510.3IL10, TNFSF13B

GO Terms for genes affiliated with Myasthenia Gravis

Sources:
16Gene Ontology
See all sources

Cellular components related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.9ACHE, TNFSF13B, CTLA4, FCGR2A, RAPSN, RYR1
2neuromuscular junctionGO:03159410.7CHRNA1, ACHE, RAPSN, MUSK
3postsynaptic membraneGO:04521110.7CHRNG, ACHE, RAPSN, MUSK, CHRNA1
4acetylcholine-gated channel complexGO:00589210.6CHRNG, CHRNA1
5cell junctionGO:03005410.4CHRNG, CHRNA1, MUSK, RAPSN, ACHE

Biological processes related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.0CTLA4, IL2, AIRE, HLA-DQB1, TNFSF13B, TNFRSF4
2T cell costimulationGO:03129510.9HLA-DQB1, CD80, CTLA4, TNFSF13B
3positive regulation of B cell proliferationGO:03089010.8TNFSF13B, IL2, TNFRSF4
4cell-cell signalingGO:00726710.8LTA, CD80, IL10, IL2
5positive regulation of immunoglobulin secretionGO:05102410.7TNFRSF4, IL2
6muscle contractionGO:00693610.7TTN, RYR1, CHRNG
7regulation of protein kinase activityGO:04585910.6TTN, TNFRSF4
8negative regulation of B cell proliferationGO:03088910.6CTLA4, IL10
9synaptic transmission, cholinergicGO:00727110.5ACHE, RAPSN
10negative regulation of growth of symbiont in hostGO:04413010.3LTA, IL10

Molecular functions related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7TNFSF13B, IL2, IL10, LTA
2acetylcholine-activated cation-selective channel activityGO:00488910.6CHRNG, CHRNA1
3acetylcholine bindingGO:04216610.5ACHE, CHRNA1
4acetylcholine receptor activityGO:01546410.3CHRNA1, CHRNG

Products for genes affiliated with Myasthenia Gravis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myasthenia Gravis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet