Myasthenia Gravis malady
Categories: Rare diseases, Neuronal diseases, Immune diseases
32LifeMap Discovery®, 10Disease Ontology, 45NIH Rare Diseases, 23Genetics Home Reference, 46NINDS, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 24GTR, 35MedlinePlus, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
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Aliases & Descriptions for Myasthenia Gravis:
Orphanet epidemiological data:51
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe),1-5/10000 (Worldwide),1-9/1000000 (United States),1-5/10000 (Canada),1-9/100000 (Spain),1-5/10000 (United Kingdom),1-9/100000 (United Kingdom),1-9/100000 (Serbia),1-5/10000 (United States),1-5/10000 (Serbia),1-9/100000 (Italy),1-5/10000 (Austria),1-9/100000 (Australia),1-5/10000 (Italy),1-9/100000 (Taiwan, Province of China),1-5/10000 (Australia),1-9/1000000 (Greece),1-5/10000 (Taiwan, Province of China),1-9/1000000 (Croatia),1-9/100000 (Estonia),1-9/100000 (Greece),1-9/100000 (Croatia); Age of onset: All ages; Age of death: normal life expectancy
Global: Rare diseases
Anatomical: Neuronal diseases, Immune diseases
ICD10: 28 27
Rare neurological diseases
MedlinePlus:35 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke
MalaCards based summary: Myasthenia Gravis, also known as autoimmune myasthenia gravis, is related to thymus cancer and gallbladder disease. An important gene associated with Myasthenia Gravis is CHRNA1 (Cholinergic Receptor Nicotinic Alpha 1 Subunit), and among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs cyclophosphamide and cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include eye, skeletal muscle and thymus, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.
NIH Rare Diseases:45 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid; facial expressions; chewing; talking; and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. the exact cause of myasthenia gravis is unknown. some cases have been linked to tumors in the thymus gland. researchers believe that variations in certain genes may increase a person's risk to develop this condition, but it is likely that other factors also play a role. there is no cure for myasthenia gravis, but lifestyle changes and some medicines may allow for periods without symptoms (remission). last updated: 3/9/2016
NINDS:46 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.
Genetics Home Reference:23 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.
Wikipedia:68 Myasthenia gravis (MG) is a neuromuscular disease that leads to fluctuating muscle weakness and fatigue.... more...
Drugs for Myasthenia Gravis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 73)
Interventional clinical trials:(show top 50) (show all 57)
Search NIH Clinical Center for Myasthenia Gravis
Inferred drug relations via UMLS65/NDF-RT43:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
MalaCards organs/tissues related to Myasthenia Gravis:33
Eye, Skeletal muscle, Thymus, Breast, Liver, Brain, T cells
MGI Mouse Phenotypes related to Myasthenia Gravis:38 (show all 14)
Articles related to Myasthenia Gravis:(show top 50) (show all 1305)
Search GEO for disease gene expression data for Myasthenia Gravis.
Pathways related to Myasthenia Gravis according to GeneCards Suite gene sharing:(show all 31)
Biological processes related to Myasthenia Gravis according to GeneCards Suite gene sharing:(show all 27)
Molecular functions related to Myasthenia Gravis according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet