MG
MCID: MYS003
MIFTS: 78

Myasthenia Gravis (MG) malady

Rare diseases, Neuronal diseases, Immune diseases categories

Summaries for Myasthenia Gravis

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22Genetics Home Reference, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest.. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke

MalaCards: Myasthenia Gravis, also known as myasthenia gravis without exacerbation, is related to thymoma and systemic lupus erythematosus. An important gene associated with Myasthenia Gravis is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Activation of Nicotinic Acetylcholine Receptors and Cytokine Network. The drugs cyclophosphamide and cyclosporine and the compounds edrophonium and gallamine have been mentioned in the context of this disorder. Affiliated tissues include thymus, eye and skeletal muscle, and related mouse phenotypes are integument and liver/biliary system.

Genetics Home Reference:22 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.

NIH Rare Diseases:44 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. last updated: 3/11/2009

NINDS:45 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.

Wikipedia:66 Myasthenia gravis (from Greek ??? \"muscle\", ???????? \"weakness\", and Latin: gravis \"serious\";... more...

Description from OMIM:48 254200,159400,607085

Aliases & Classifications for Myasthenia Gravis

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9Disease Ontology, 44NIH Rare Diseases, 23GTR, 22Genetics Home Reference, 45NINDS, 11DISEASES, 46Novoseek, 50Orphanet, 48OMIM, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 28ICD9CM, 36MeSH, 41NCIt, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

50
myasthenia gravis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

myasthenia gravis 9 44 23 22 45 11 46 50 48 35 32 63
myasthenia gravis without exacerbation 9
myasthenia gravis with exacerbation 9
autoimmune myasthenia gravis 50
myasthenia gravis nos 9
acquired myasthenia 50
mg 22


External Ids:

Disease Ontology9 DOID:437
ICD9CM28 358.0
MeSH36 D009157
NCIt41 C60989
MESH via Orphanet37 D009157
ICD10 via Orphanet27 G70.0
SNOMED-CT via Orphanet60 91637004
UMLS via Orphanet64 C0026896

Related Diseases for Myasthenia Gravis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Myasthenia Gravis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 327)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.7TNFRSF4, TTN, MUSK, CTLA4, RYR1
2systemic lupus erythematosus30.9FCGR2A, TNFSF13B
3polymyositis30.6CTLA4, TTN
4graves' disease30.6HLA-DQB1, TNFRSF4, CTLA4, LTA
5multiple sclerosis30.6HLA-DQB1, TNFSF13B, IL10, CTLA4, LTA
6congenital myasthenic syndrome30.6CHRNG, CHRNA1, MUSK
7myopathy30.6RYR1, RAPSN, ACHE, TTN
8meningitis30.5FCGR2A
9uveitis30.4LTA, CTLA4, IL10
10respiratory failure30.4RYR1, MUSK, TTN
11neuromuscular disease30.4RYR1, MUSK, TTN
12neuropathy30.4RYR1, RAPSN, TTN
13hepatitis c30.4CTLA4, IL10, TNFSF13B
14arthritis30.3FCGR2A, IL10, CTLA4, LTA
15endplate acetylcholinesterase deficiency30.3ACHE
16asthma30.3TNFSF13B, TNFRSF4, IL10, CTLA4
17lepromatous leprosy30.3LTA, IL10
18tetanus30.2LTA, IL10, ACHE
19autoimmune hepatitis30.1CTLA4, HLA-DQB1
20rheumatoid arthritis30.1HLA-DQB1, TNFSF13B, TNFRSF4, FCGR2A, IL10, CTLA4
21encephalomyelitis29.9HLA-DQB1, TNFSF13B, TNFRSF4, IL10, CTLA4, LTA
22neonatal myasthenia gravis10.9
23lambert-eaton myasthenic syndrome10.8
24juvenile myasthenia gravis10.7
25pemphigus10.7
26thymic hyperplasia10.7
27lupus erythematosus10.6
28thyroiditis10.6
29ophthalmoplegia10.5
30polyneuropathy10.5
31lambert syndrome10.5
32pure red-cell aplasia10.5
33muscular dystrophy10.5
34pemphigus foliaceus10.5
35demyelinating polyneuropathy10.5
36mediastinitis10.5
37myocarditis10.5
38rippling muscle disease10.5
39myasthenia gravis, neonatal transient10.5
40myasthenia gravis with thymus hyperplasia10.5
41adult-onset myasthenia gravis10.5
42neuromyelitis optica10.4
43internuclear ophthalmoplegia10.4
44facioscapulohumeral muscular dystrophy10.4
45alopecia10.4
46cervicitis10.4
47hypothyroidism10.4
48myositis10.4
49chronic inflammatory demyelinating polyneuropathy10.4
50rippling muscle disease with myasthenia gravis10.4

Graphical network of the top 20 diseases related to Myasthenia Gravis:



Diseases related to myasthenia gravis

Symptoms for Myasthenia Gravis

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48OMIM
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Symptoms by clinical synopsis from OMIM:

159400

Clinical features from OMIM:

254200,159400,607085

Drugs & Therapeutics for Myasthenia Gravis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myasthenia Gravis

Drug clinical trials:

Search ClinicalTrials for Myasthenia Gravis

Search NIH Clinical Center for Myasthenia Gravis

Search CenterWatch for Myasthenia Gravis

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Hematopoietic stem cells for refractory myasthenia gravis
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Myasthenia Gravis

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23GTR
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Genetic tests related to Myasthenia Gravis:

id Genetic test Affiliating Genes
1 Myasthenia Gravis23

Anatomical Context for Myasthenia Gravis

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34MalaCards
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MalaCards organs/tissues related to Myasthenia Gravis:

34
Thymus, Eye, Skeletal muscle, T cells, B cells, Thyroid, Testes, Bone, Bone marrow, Heart, Lung, Prostate, Monocytes, Breast, Brain, Uterus, Kidney, Spleen, Tongue, Pituitary

Animal Models for Myasthenia Gravis or affiliated genes

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38MGI
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Publications for Myasthenia Gravis

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53PubMed
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Articles related to Myasthenia Gravis:

(show top 50)    (show all 1178)
idTitleAuthorsYear
1
Delivery of an miR155 inhibitor by anti-CD20 single chain antibody into B cells reduces the AChR-specific auto-antibodies and ameliorates experimental autoimmune myasthenia gravis. (24387321)
2014
2
Molecular docking cannot accurately predict drug off-target effects: Implications for the role of voriconazole in the exacerbation of myasthenia gravis. (24127354)
2014
3
Complete stable remission and autoantibody specificity in myasthenia gravis. (23255823)
2013
4
Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus. (22840813)
2013
5
Thymic tumours associated with Myasthenia gravis: a long term observation study of operated patients. (23944622)
2013
6
Leg pain in a patient with myasthenia gravis. (23613264)
2013
7
Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: A population-based cohort study. (24332676)
2013
8
Tuberculosis in myasthenia gravis. (23232007)
2013
9
Myasthenia gravis developing in an HIV-negative patient with Kaposi's sarcoma. (23010878)
2013
10
Surgical treatment of myasthenia gravis: evident benefits and insidious pitfalls of mini-invasive techniques. (24088481)
2013
11
Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase. (23535158)
2013
12
Chronic urticaria in myasthenia gravis patients - More than occasional coexistence? (23972403)
2013
13
Analysis of outcomes following surgical treatment of thymolipomatous myasthenia gravis: comparison with thymomatous and non-thymomatous myasthenia gravis. (24366316)
2013
14
An ocular form of myasthenia gravis with a high titer of anti-MuSK antibodies during a long-term follow-up. (23124154)
2012
15
Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. (22367834)
2012
16
Clinical significance of detection of antibodies to fetal and adult acetylcholine receptors in myasthenia gravis. (22961471)
2012
17
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
18
Unilateral extended thoracoscopic thymectomy for nontumoral myasthenia gravis--a new standard. (22920527)
2012
19
Patient registries: useful tools for clinical research in myasthenia gravis. (23252904)
2012
20
Low-dose glucocorticoid therapy complements the pituitary-adrenocortical system and reduces anxiety and insomnia in myasthenia gravis patients. (22240858)
2012
21
Antibodies to low density lipoprotein receptor-related protein 4 in seronegative myasthenia gravis. (22158717)
2012
22
Mosaic caveolin-3 expression in acquired rippling muscle disease without evidence of myasthenia gravis or acetylcholine receptor autoantibodies. (21295981)
2011
23
Robotic thymectomy for myasthenia gravis. (22042404)
2011
24
Investigation for RAPSN and DOK-7 mutations in a cohort of seronegative myasthenia gravis patients. (21305573)
2011
25
Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis. (22316202)
2011
26
Thymoma: inter-relationships among World Health Organization histology, Masaoka staging and myasthenia gravis and their independent prognostic significance: a single-centre experience. (21093283)
2011
27
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
28
Widely varying TNF-alpha levels in patients with myasthenia gravis. (19214380)
2009
29
Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis. (17255332)
2007
30
Effect of sera from AChR-antibody negative myasthenia gravis patients on AChR and MuSK in cell cultures. (17335909)
2007
31
Acquired von Willebrand's syndrome in a patient with severe primary hypothyroidism associated with myasthenia gravis in the course of autoimmune polyglandular syndrome type 3. (17880463)
2007
32
Dandy-Walker syndrome in adult mimicking myasthenia gravis. (17420852)
2007
33
Myasthenia gravis masquerading as post-poliomyelitis syndrome. (16546772)
2006
34
Seronegative neonatal myasthenia gravis in one of the twins. (15475637)
2004
35
Acquired rippling muscle disease with myasthenia gravis. (14694511)
2004
36
Seronegative myasthenia gravis]. (15034472)
2004
37
Myasthenia gravis in individuals over 40. (14592910)
2003
38
Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis. (12707978)
2003
39
Stiff person syndrome and myasthenia gravis. (11960163)
2002
40
Major review: the clinical spectrum of pediatric myasthenia gravis: blepharoptosis, ophthalmoplegia and strabismus. A report of 14 cases. (12171588)
2002
41
Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. (11231638)
2001
42
Decreased mRNA expression of TNF-alpha and IL-10 in non-stimulated peripheral blood mononuclear cells in myasthenia gravis. (10809941)
2000
43
Cell-mediated immune response against titin in myasthenia gravis: evidence for the involvement of Th1 and Th2 cells. (9467662)
1998
44
FcgammaRIIA and FcgammaRIIIB polymorphisms in myasthenia gravis. (9521619)
1998
45
Myasthenia gravis sera containing antiryanodine receptor antibodies inhibit binding of [3H]-ryanodine to sarcoplasmic reticulum. (9486861)
1998
46
A patient with a relapse of myasthenia gravis after a 13-year remission following successful treatment by mediastinal irradiation and corticosteroid therapy]. (7605688)
1995
47
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
48
A novel HLA-DR4 allele (DRB1*0414) in a patient with myasthenia gravis. (1481204)
1992
49
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
50
Letter: Neonatal myasthenia gravis. (4448549)
1974

Variations for Myasthenia Gravis

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Expression for genes affiliated with Myasthenia Gravis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myasthenia Gravis

Search GEO for disease gene expression data for Myasthenia Gravis.

Pathways for genes affiliated with Myasthenia Gravis

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 61Thomson Reuters, 31KEGG, 58SinoBiological, 55R&D Systems, 39NCBI BioSystems Database
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Pathways related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CHRNG, CHRNA1
29.8LTA, IL10
3
Show member pathways
9.6ACHE, CHRNG, CHRNA1
49.6RAPSN, CHRNA1, MUSK
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.4TNFRSF4, TNFSF13B
69.3TNFRSF4, IL10, LTA
7
Show member pathways
9.2CHRNA1, LTA, RYR1
8
Show member pathways
9.1MUSK, CHRNA1, CHRNG, RYR1
9
Show member pathways
9.0TNFSF13B, TNFRSF4, LTA
10
Show member pathways
8.9TNFSF13B, MUSK, IL10, LTA
118.8HLA-DQB1, FCGR2A, IL10
12
Show member pathways
8.8IL10, FCGR2A, HLA-DQB1
138.8HLA-DQB1, FCGR2A, IL10
14
Show member pathways
8.7LTA, IL10, TNFRSF4, TNFSF13B
158.7CTLA4, TNFSF13B, HLA-DQB1
16
Show member pathways
8.5TNFSF13B, TNFRSF4, MUSK, IL10, LTA
17
Show member pathways
8.5LTA, IL10, MUSK, TNFRSF4, TNFSF13B
18
Show member pathways
8.5LTA, IL10, MUSK, TNFRSF4, TNFSF13B
19
Show member pathways
8.2HLA-DQB1, TNFSF13B, TNFRSF4, LTA
20
Show member pathways
8.0LTA, CTLA4, IL10, TNFSF13B, HLA-DQB1

Compounds for genes affiliated with Myasthenia Gravis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1edrophonium46 1211.4MUSK, ACHE
2gallamine46 3011.3ACHE, CHRNA1
3glatiramer acetate46 1211.1CTLA4, IL10
4toxin-14610.1IL10, LTA
5galantamine46 52 1212.1CHRNA1, CHRNG, ACHE
6indoleamine4610.1IL10, CTLA4
7cyclosporine52 1211.0LTA, IL10
8natalizumab46 1211.0IL10, FCGR2A
9adalimumab46 52 1211.9IL10, FCGR2A
10nicotine46 30 52 1212.9MUSK, CHRNA1, ACHE
11blys469.9TNFSF13B, IL10
12okt3469.9LTA, IL10
13con a469.9CTLA4, IL10
14propionate469.9RYR1, IL10
15enterotoxin469.9LTA, CTLA4
16il 10469.8IL10, CTLA4, LTA
17mycophenolate mofetil46 52 1211.8IL10, CTLA4, LTA
18succinylcholine46 52 30 1212.8RYR1, ACHE, CHRNA1
19lipoteichoic acid469.8LTA, IL10
20ryanodine46 30 6211.7TTN, MUSK, RYR1
21tgf beta1469.7LTA, CTLA4, IL10
22etanercept46 52 1211.7LTA, IL10, FCGR2A
23ivig469.6LTA, IL10, FCGR2A
24prednisolone46 30 1211.6LTA, IL10, FCGR2A
25tacrolimus46 52 1211.6RYR1, CTLA4, IL10
26digoxin46 62 52 25 1213.6IL10, RYR1
27rantes469.6IL10, CTLA4, LTA
28ecori469.5HLA-DQB1, LTA
29potassium46 25 1211.4TTN, MUSK, RAPSN, RYR1
30vitamin d469.4LTA, CTLA4, IL10
31ionomycin469.4LTA, CTLA4, IL10, TNFRSF4
32infliximab46 52 1211.3FCGR2A, IL10, CTLA4, LTA
33cyclosporin a46 30 6211.3TNFRSF4, IL10, CTLA4, LTA
34rituximab46 52 1210.8TNFSF13B, FCGR2A, MUSK, IL10, CTLA4
35threonine468.5LTA, CTLA4, FCGR2A, TTN
36lipid468.5RYR1, LTA, CTLA4, RAPSN, MUSK, FCGR2A
37serine468.4TTN, FCGR2A, ACHE, CTLA4, LTA, RYR1
38glutamate468.1HLA-DQB1, TTN, ACHE, CTLA4, LTA, RYR1
39tyrosine468.1LTA, CTLA4, RAPSN, MUSK, FCGR2A, HLA-DQB1
40acetylcholine46 52 30 25 1212.1RYR1, TTN, MUSK, CHRNA1, ACHE, RAPSN
41calcium46 52 25 1210.5TNFSF13B, TTN, FCGR2A, MUSK, RAPSN, CTLA4

GO Terms for genes affiliated with Myasthenia Gravis

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17Gene Ontology
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Cellular components related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:0058929.9CHRNG, CHRNA1
2neuromuscular junctionGO:0315949.5RAPSN, ACHE, CHRNA1, MUSK
3I bandGO:0316749.3RYR1, TTN
4postsynaptic membraneGO:0452119.2MUSK, CHRNA1, CHRNG, ACHE, RAPSN
5cell junctionGO:0300549.2MUSK, CHRNA1, CHRNG, ACHE, RAPSN
6Golgi apparatusGO:0057949.2CTLA4, RAPSN, ACHE, TTN
7integral component of plasma membraneGO:0058878.5TNFRSF4, MUSK, CHRNG, CTLA4, RYR1
8plasma membraneGO:0058866.8HLA-DQB1, TNFSF13B, FCGR2A, CHRNA1, CHRNG, ACHE

Biological processes related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.0RAPSN, ACHE
2negative regulation of B cell proliferationGO:03088910.0IL10, CTLA4
3negative regulation of growth of symbiont in hostGO:04413010.0IL10, LTA
4positive regulation of neuron apoptotic processGO:0435259.9RAPSN, MUSK
5negative regulation of T cell proliferationGO:0421309.8IL10, CTLA4
6neuromuscular junction developmentGO:0075289.8CHRNA1, MUSK
7regulation of protein kinase activityGO:0458599.7TTN, TNFRSF4
8muscle contractionGO:0069369.6RYR1, CHRNG, TTN
9synaptic transmissionGO:0072689.5RAPSN, ACHE, CHRNG, CHRNA1
10positive regulation of B cell proliferationGO:0308909.1TNFRSF4, TNFSF13B
11T cell costimulationGO:0312958.9CTLA4, TNFSF13B, HLA-DQB1
12immune responseGO:0069558.4HLA-DQB1, TNFSF13B, TNFRSF4, CTLA4

Molecular functions related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine bindingGO:04216610.0ACHE, CHRNA1
2acetylcholine receptor activityGO:01546410.0CHRNG, CHRNA1
3acetylcholine-activated cation-selective channel activityGO:0048899.9CHRNG, CHRNA1
4protein self-associationGO:0436219.9ACHE, TTN
5tumor necrosis factor receptor bindingGO:0051649.1LTA, TNFSF13B
6cytokine activityGO:0051259.1TNFSF13B, IL10, LTA

Products for genes affiliated with Myasthenia Gravis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myasthenia Gravis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet