MG
MCID: MYS003
MIFTS: 79

Myasthenia Gravis (MG) malady

Neuronal diseases category

Summaries for Myasthenia Gravis

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest.. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke

MalaCards: Myasthenia Gravis, also known as myasthenia gravis without exacerbation, is related to thymoma and lambert-eaton myasthenic syndrome. An important gene associated with Myasthenia Gravis is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The drugs cyclophosphamide and cyclosporine and the compounds tyrosine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include eye, skeletal muscle and thymus, and related mouse phenotypes are mortality/aging and respiratory system.

NIH Rare Diseases:42 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. last updated: 3/11/2009

NINDS:43 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.

Genetics Home Reference:21 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.

Wikipedia:63 Myasthenia gravis (from Greek μύς \"muscle\", ἀσθένεια \"weakness\", and Latin: gravis... more...

Description from OMIM:46 254200,159400,607085

Aliases & Classifications for Myasthenia Gravis

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
myasthenia gravis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

myasthenia gravis 8 42 22 21 43 10 44 48 46 33 30 60
myasthenia gravis without exacerbation 8
myasthenia gravis with exacerbation 8
autoimmune myasthenia gravis 48
myasthenia gravis nos 8
acquired myasthenia 48
mg 21


External Ids:

Disease Ontology8 DOID:437
MeSH34 D009157
NCIt39 C60989
ICD9CM27 358.0
MESH via Orphanet35 D009157
ICD10 via Orphanet26 G70.0
SNOMED-CT via Orphanet57 91637004
UMLS via Orphanet61 C0026896

Related Diseases for Myasthenia Gravis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Myasthenia Gravis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.7IL2, MUSK, AIRE, CTLA4, TNFRSF4, RYR1
2lambert-eaton myasthenic syndrome31.1MUSK
3thyroiditis30.9CTLA4
4systemic lupus erythematosus30.8FCGR2A, TNFSF13B
5polyneuropathy30.7ACHE
6multiple sclerosis30.7TNFSF13B, CTLA4, HLA-DQB1, LTA, CD80, IL10
7graves' disease30.7TNFRSF4, CTLA4, HLA-DQB1, AIRE, LTA, CD80
8hypothyroidism30.6AIRE, CTLA4
9myositis30.6TTN, RYR1
10alopecia30.6AIRE
11myopathy30.5RYR1, TTN, RAPSN, ACHE
12autoimmune thyroiditis30.5CD80, AIRE, CTLA4
13leukemia30.4TNFRSF4, LTA, MUSK, CD80, IL2, ACHE
14respiratory failure30.4TTN, RYR1, MUSK
15congenital myasthenic syndrome30.4CHRNA1, MUSK, RAPSN
16hepatitis30.4LTA, AIRE, CTLA4
17alopecia areata30.4AIRE
18glomerulonephritis30.4FCGR2A
19neuromuscular disease30.4TTN, RYR1, MUSK
20lung cancer30.4IL2
21rheumatoid arthritis30.3TNFSF13B, TNFRSF4, CTLA4, HLA-DQB1, LTA, CD80
22asthma30.3TNFSF13B, TNFRSF4, CTLA4, CD80, IL10
23arthritis30.3CTLA4, LTA, CD80, IL10, FCGR2A
24neuropathy30.3RAPSN, TTN, RYR1
25diabetes mellitus30.3AIRE, HLA-DQB1, CTLA4
26hepatitis c30.3TNFSF13B, CTLA4, IL10, IL2
27vitiligo30.3CTLA4, AIRE
28uveitis30.3CTLA4, LTA, IL10
29addison's disease30.3AIRE, CTLA4
30dermatitis30.3CTLA4
31candidiasis30.3AIRE
32connective tissue disease30.3IL2, IL10, CTLA4
33meningitis30.3FCGR2A
34breast cancer30.3CTLA4, CD80, IL2
35myeloid leukemia30.1LTA
36encephalomyelitis30.1TNFSF13B, TNFRSF4, CTLA4, HLA-DQB1, LTA, CD80
37tetanus30.1LTA, CD80, IL10, IL2, ACHE
38lepromatous leprosy30.1LTA, IL10, IL2
39melanoma30.1FCGR2A, IL2, IL10, CD80, CTLA4, TNFRSF4
40tuberculosis30.1IL2, IL10, HLA-DQB1
41myeloma30.1TNFSF13B, LTA, CD80, IL2
42leprosy30.1IL2
43optic neuritis30.1LTA
44chronic mucocutaneous candidiasis30.1IL10, AIRE
45pancreatitis30.1IL10
46autoimmune hepatitis30.1AIRE, HLA-DQB1, CTLA4
47colorectal cancer30.1IL2, CD80
48achalasia30.1ACHE
49primary biliary cirrhosis30.1CTLA4, AIRE, LTA
50thrombocytopenia30.1FCGR2A, IL2

Graphical network of the top 20 diseases related to Myasthenia Gravis:



Diseases related to myasthenia gravis

Clinical Features for Myasthenia Gravis

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46OMIM
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Clinical features from OMIM:

254200,159400,607085

Clinical synopsis from OMIM:

159400

Drugs & Therapeutics for Myasthenia Gravis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myasthenia Gravis

Drug clinical trials:

Search ClinicalTrials for Myasthenia Gravis

Search NIH Clinical Center for Myasthenia Gravis

Search CenterWatch for Myasthenia Gravis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Hematopoietic stem cells for refractory myasthenia gravis
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Myasthenia Gravis

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22GTR
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Genetic tests related to Myasthenia Gravis:

id Genetic test Affiliating Genes
1 Myasthenia Gravis22

Anatomical Context for Myasthenia Gravis

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32MalaCards
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MalaCards organs/tissues related to Myasthenia Gravis:

32
Eye, Skeletal muscle, Thymus, T cells, B cells, Thyroid, Testes, Bone, Bone marrow, Lung, Heart, Breast, Uterus, Prostate, Kidney, Monocytes, Brain, Spleen, Tongue, Pituitary

Animal Models for Myasthenia Gravis or affiliated genes

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36MGI
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Publications for Myasthenia Gravis

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Sources:
50PubMed
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Articles related to Myasthenia Gravis:

(show top 50)    (show all 1196)
idTitleAuthorsYear
1
Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: A population-based cohort study. (24332676)
2013
2
Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase. (23535158)
2013
3
Reliability of SFEMG in diagnosing myasthenia gravis: Sensitivity and specificity calculated on 100 prospective cases. (24296278)
2013
4
An unexpected difficult intubation in a patient with myasthenia gravis undergoing video-assisted transcervical thymectomy. (23749836)
2013
5
Is the decremental pattern in Lambert-Eaton syndrome different from that in myasthenia gravis? (24332471)
2013
6
Muscle-specific regulation of the mTOR signaling pathway in MuSK antibody seropositive (MuSK+) experimental autoimmune Myasthenia gravis (EAMG). (23933211)
2013
7
Successful treatment of severe myasthenia gravis developed after allogeneic hematopoietic stem cell transplantation with plasma exchange and rituximab. (24307660)
2013
8
Myasthenia gravis: analysis of serum autoantibody reactivities to 1827 potential human autoantigens by protein macroarrays. (23483977)
2013
9
Multiple supratentorial brain abscesses due to Listeria monocytogenes in a patient with myasthenia gravis. (23751195)
2013
10
Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis. (22981737)
2013
11
Asthma as a cause of persistent dyspnea in treated myasthenia gravis patients. (23051847)
2012
12
Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis. (22158716)
2012
13
Exacerbation of myasthenia gravis after postoperative radiotherapy for a thymoma. (22427292)
2012
14
Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication: A case report and review of literature. (22375266)
2012
15
Neurophysiological characteristics of MuSK antibody positive myasthenia gravis mice: focal denervation and hypersensitivity to acetylcholinesterase inhibitors. (22251934)
2012
16
Clinical manifestations of acetylcholine receptor antibody positive and negative myasthenia gravis. (22550827)
2012
17
Profound olfactory dysfunction in myasthenia gravis. (23082113)
2012
18
Miller Fisher syndrome mimicking ocular myasthenia gravis. (23190719)
2012
19
First Report of Nocardia asiatica Presenting as an Anterior Mediastinal Mass in a Patient with Myasthenia Gravis: A Case Report and Review of the Literature. (22844621)
2012
20
AchR-positive myasthenia gravis with MRI evidence of early muscle atrophy. (22341149)
2012
21
Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells. (22835429)
2012
22
Autoimmune myasthenia gravis after sternal fracture. (22393321)
2012
23
Robotic thymectomy for myasthenia gravis. (22042404)
2011
24
Prolonged Dyspnea after Interscalene Block: Attributed to Undiagnosed Addison's Disease and Myasthenia Gravis. (21687552)
2011
25
Multiple paraneoplastic syndromes: myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma. (21689830)
2011
26
Ectopic cervical thymoma in a patient with myasthenia gravis. (21733179)
2011
27
Thymoma-associated exfoliative dermatitis with post-thymectomy myasthenia gravis in a cat. (20885830)
2010
28
Up-regulation of MHC class I and class II in the skeletal muscles of myasthenia gravis. (20546939)
2010
29
Changes in serum cytokine levels during plasmapheresis in patients with myasthenia gravis. (19614971)
2009
30
Correlation of C3 level with severity of generalized myasthenia gravis. (19670317)
2009
31
Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis. (18595775)
2008
32
Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. (18250419)
2008
33
Anti-MuSK antibody positive myasthenia gravis with HIV infection successfully treated with cyclosporin: a case report]. (19048951)
2008
34
Myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient. (17206662)
2007
35
CCR2-64I and CCR5Delta32 Polymorphisms in Korean Patients with Myasthenia Gravis. (19513280)
2007
36
MuSK antibody-positive, seronegative myasthenia gravis in Korea. (16546389)
2006
37
A case of ocular myasthenia gravis and Miller-Fisher syndrome. (15739712)
2005
38
The features of myasthenia gravis with autoantibodies to MuSK. (16024887)
2005
39
Paraneoplastic pemphigus associated with Castleman tumor, myasthenia gravis and bronchiolitis obliterans. (10459112)
1999
40
Striational autoantibodies in myasthenia gravis patients recognize I-band titin epitopes. (9521611)
1998
41
Comparative effects of plasma exchange and pyridostigmine on respiratory muscle strength and breathing pattern in patients with myasthenia gravis. (7491557)
1995
42
Transforming growth factor-beta 1 suppresses autoantigen-induced expression of pro-inflammatory cytokines but not of interleukin-10 in multiple sclerosis and myasthenia gravis. (7537278)
1995
43
Atrophy of the tongue with persistent articulation disorder in myasthenia gravis: report of 10 patients. (7779022)
1994
44
In situ expression of IL-1 beta and IL-2 mRNA in thymuses from patients with myasthenia gravis]. (7924056)
1994
45
Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. (1522245)
1992
46
Antibodies to acetylcholine receptors in myasthenia gravis. In vitro synthesis by peripheral blood lymphocytes before and after thymectomy. (1735188)
1992
47
Overlap myasthenic syndrome: combined myasthenia gravis and Eaton-Lambert syndrome. (3614671)
1987
48
Myasthenia gravis, premature menopause, and thyroid autoimmunity. (7405986)
1980
49
Neonatal myasthenia gravis and antimuscle antibodies. (4926622)
1971
50
Vitamin A--responsive pityriasis rubra pilaris with myasthenia gravis. (5835336)
1965

Genetic Variations for Myasthenia Gravis

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Expression for genes affiliated with Myasthenia Gravis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myasthenia Gravis

Search GEO for disease gene expression data for Myasthenia Gravis.

Pathways for genes affiliated with Myasthenia Gravis

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Sources:
51QIAGEN, 29KEGG, 55SinoBiological, 52R&D Systems, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8TNFSF13B, TNFRSF4, LTA, MUSK, CD80, IL10
2
Hide members
10.8IL2, IL10, CD80, MUSK, LTA, TNFSF13B
3
Hide members
10.8IL10, CD80, LTA, HLA-DQB1, CTLA4, TNFSF13B
4
Hide members
10.7CHRNG, CHRNA1, MUSK, IL2, RYR1
5
Hide members
10.7FCGR2A, IL2, CD80, MUSK, HLA-DQB1
6
Hide members
10.7TNFRSF4, LTA, MUSK, CD80
7
Hide members
10.7LTA, HLA-DQB1, TNFRSF4, TNFSF13B
8
Hide members
10.7TNFSF13B, TNFRSF4, MUSK, CD80
910.7TNFSF13B, CTLA4, HLA-DQB1, CD80
10
Hide members
10.7TNFSF13B, TNFRSF4, LTA, CD80
1110.7TNFRSF4, LTA, IL10, IL2
12
Hide members
10.7HLA-DQB1, IL10, IL2, FCGR2A
13
Hide members
10.7IL2, CD80, HLA-DQB1, CTLA4
14
Hide members
10.7FCGR2A, IL10, CD80, HLA-DQB1
15
Hide members
10.7LTA, CD80, IL10, IL2
1610.6RAPSN, MUSK, CHRNA1
1710.6FCGR2A, IL2, TNFSF13B
1810.6HLA-DQB1, IL10, FCGR2A
1910.6LTA, IL10, IL2
20
Hide members
10.6CTLA4, HLA-DQB1, CD80
21
Hide members
10.6CHRNA1, CHRNG

Compounds for genes affiliated with Myasthenia Gravis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.3CTLA4, HLA-DQB1, AKAP12, AIRE, LTA, MUSK
2acetylcholine44 49 28 11 2415.3CTLA4, CHRNA1, LTA, MUSK, RYR1, TTN
3rituximab44 49 1113.2FCGR2A, TNFSF13B, CTLA4, MUSK, CD80, IL10
4calcium44 49 11 2414.2TNFSF13B, CTLA4, LTA, MUSK, CD80, RYR1
5ionomycin4411.2TNFRSF4, CTLA4, LTA, CD80, IL10, IL2
6cyclosporin a44 28 5913.1IL2, IL10, CD80, LTA, CTLA4, TNFRSF4
7serine4411.1ACHE, FCGR2A, TTN, RYR1, LTA, CTLA4
8rapamycin4411.1RYR1, IL2, IL10, CD80, CTLA4
9il 104411.1CTLA4, LTA, IL10, IL2
10prednisolone44 28 1113.0FCGR2A, IL2, IL10, LTA
11succinylcholine44 28 1113.0ACHE, RYR1, CHRNA1
12ctla4-ig4411.0IL2, CD80, CTLA4
13galantamine44 49 1113.0ACHE, CHRNA1, CHRNG
14toxin-14411.0LTA, IL10, IL2
15glatiramer acetate44 1112.0CTLA4, IL10, IL2
16enterotoxin4411.0CTLA4, LTA, CD80
17okt34411.0LTA, IL10, IL2
18con a4411.0IL2, IL10, CTLA4
19tacrolimus44 49 1113.0CTLA4, IL10, IL2, RYR1
20etanercept44 49 1113.0LTA, IL10, FCGR2A
21edrophonium44 1111.9ACHE, MUSK
22mycophenolate mofetil44 49 1112.9CTLA4, IL10, IL2
23belatacept44 1111.9CD80, CTLA4
24infliximab44 49 1112.9IL10, LTA, CTLA4
25gallamine44 2811.9ACHE, CHRNA1
26ivig4410.9FCGR2A, IL10, LTA
27abatacept44 1111.9CD80, CTLA4
28glutamate4410.8RYR1, TTN, ACHE
29ryanodine44 28 5912.8TTN, RYR1, MUSK
30pentoxifylline44 1111.8LTA
31neopterin4410.8LTA, IL10, IL2
32interferon gamma4410.7IL2, IL10
33rantes4410.7IL2, LTA
34allergens4410.7IL10, CD80, CTLA4
35daclizumab44 1111.6FCGR2A, IL2
36alpha-galactosylceramide4410.6IL10, IL2
37thalidomide44 49 59 1113.5IL2, IL10, CTLA4
38blys4410.3IL10, TNFSF13B

GO Terms for genes affiliated with Myasthenia Gravis

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16Gene Ontology
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Cellular components related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.9TNFSF13B, CTLA4, HLA-DQB1, AKAP12, CHRNG, CHRNA1
2neuromuscular junctionGO:03159410.7ACHE, RAPSN, MUSK, CHRNA1
3postsynaptic membraneGO:04521110.7CHRNG, CHRNA1, MUSK, RAPSN, ACHE
4acetylcholine-gated channel complexGO:00589210.6CHRNA1, CHRNG
5cell junctionGO:03005410.4CHRNG, CHRNA1, MUSK, RAPSN, ACHE

Biological processes related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.0IL2, AIRE, HLA-DQB1, CTLA4, TNFRSF4, TNFSF13B
2T cell costimulationGO:03129510.9TNFSF13B, CTLA4, HLA-DQB1, CD80
3positive regulation of B cell proliferationGO:03089010.8IL2, TNFRSF4, TNFSF13B
4cell-cell signalingGO:00726710.8LTA, CD80, IL10, IL2
5positive regulation of immunoglobulin secretionGO:05102410.7IL2, TNFRSF4
6muscle contractionGO:00693610.7TTN, RYR1, CHRNG
7regulation of protein kinase activityGO:04585910.6TTN, TNFRSF4
8negative regulation of B cell proliferationGO:03088910.6CTLA4, IL10
9synaptic transmission, cholinergicGO:00727110.5ACHE, RAPSN
10negative regulation of growth of symbiont in hostGO:04413010.3IL10, LTA

Molecular functions related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL2, IL10, LTA, TNFSF13B
2acetylcholine-activated cation-selective channel activityGO:00488910.6CHRNA1, CHRNG
3acetylcholine bindingGO:04216610.5CHRNA1, ACHE
4acetylcholine receptor activityGO:01546410.3CHRNA1, CHRNG

Products for genes affiliated with Myasthenia Gravis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myasthenia Gravis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet