MG
MCID: MYS003
MIFTS: 78

Myasthenia Gravis (MG) malady

Rare diseases, Neuronal diseases, Immune diseases categories
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Summaries for Myasthenia Gravis

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MedlinePlus:33 Myasthenia gravis is disease that causes weakness in the muscles under your control. it happens because of a problem in communication between your nerves and muscles. myasthenia gravis is an autoimmune disease. your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. this makes your muscles weaker. common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. but it can also affect other muscles. the weakness gets worse with activity, and better with rest.. there are medicines to help improve nerve-to-muscle messages and make muscles stronger. with treatment, the muscle weakness often gets much better. other drugs keep your body from making so many abnormal antibodies. there are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. sometimes surgery to take out the thymus gland helps. for some people, myasthenia gravis can go into remission and they do not need medicines. the remission can be temporary or permanent. if you have myasthenia gravis, it is important to follow your treatment plan. if you do, you can expect your life to be normal or close to it. nih: national institute of neurological disorders and stroke

MalaCards based summary: Myasthenia Gravis, also known as autoimmune myasthenia gravis, is related to thymoma and systemic lupus erythematosus, and has symptoms including An important gene associated with Myasthenia Gravis is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Activation of Nicotinic Acetylcholine Receptors and Cytokine Network. The drugs cyclophosphamide and cyclosporine and the compounds edrophonium and gallamine have been mentioned in the context of this disorder. Affiliated tissues include eye, thymus and skeletal muscle, and related mouse phenotypes are integument and liver/biliary system.

Genetics Home Reference:21 Myasthenia gravis is a disorder that causes weakness of the skeletal muscles, which are muscles that the body uses for movement. The weakness most often starts in the muscles around the eyes, causing drooping of the eyelids (ptosis) and difficulty coordinating eye movements, which results in blurred or double vision. In a form of the disorder called ocular myasthenia, the weakness remains confined to the eye muscles. In most people with myasthenia gravis, however, additional muscles in the face and neck are affected. Affected individuals may have unusual facial expressions, difficulty holding up the head, speech impairment (dysarthria), and chewing and swallowing problems (dysphagia) that may lead to choking, gagging, or drooling.

NIH Rare Diseases:42 Myasthenia gravis is a chronic autoimmune neuromuscular disease. it is characterized by varying degrees of weakness of the skeletal muscles of the body. common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. weakness tends to increase during periods of activity and improves after periods of rest. last updated: 3/11/2009

NINDS:43 Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. Symptoms vary in type and intensity.

Wikipedia:65 Myasthenia gravis (from Greek ??? \"muscle\", ???????? \"weakness\", and Latin: gravis \"serious\";... more...

Descriptions from OMIM:46 254200,159400,607085

Aliases & Classifications for Myasthenia Gravis

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Myasthenia Gravis, Aliases & Descriptions:

Name: Myasthenia Gravis 30 8 42 22 21 43 10 44 48 46 33 62
Autoimmune Myasthenia Gravis 48
 
Acquired Myasthenia 48
Mg 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
myasthenia gravis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:437
ICD9CM27 358.0
NCIt39 C60989
MeSH34 D009157
MESH via Orphanet35 D009157
ICD10 via Orphanet26 G70.0
UMLS via Orphanet63 C0026896

Related Diseases for Myasthenia Gravis

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Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Myasthenia Gravis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1thymoma31.5MUSK, CTLA4, RYR1, TNFRSF4, TTN
2systemic lupus erythematosus31.2FCGR2A, TNFSF13B
3congenital myasthenic syndrome31.0CHRNG, MUSK, CHRNA1
4endplate acetylcholinesterase deficiency31.0ACHE
5polymyositis30.9TTN, CTLA4
6respiratory failure30.8MUSK, TTN, RYR1
7meningitis30.7FCGR2A
8lepromatous leprosy30.7LTA, IL10
9uveitis30.7LTA, CTLA4, IL10
10myopathy30.7RAPSN, TTN, ACHE, RYR1
11neuromuscular disease30.6MUSK, RYR1, TTN
12neuropathy30.6RYR1, RAPSN, TTN
13hepatitis c30.5TNFSF13B, IL10, CTLA4
14tetanus30.5IL10, LTA, ACHE
15graves' disease30.4CTLA4, LTA, TNFRSF4, HLA-DQB1
16arthritis30.3LTA, FCGR2A, IL10, CTLA4
17asthma30.2TNFRSF4, TNFSF13B, IL10, CTLA4
18multiple sclerosis30.2LTA, CTLA4, IL10, TNFSF13B, HLA-DQB1
19autoimmune hepatitis30.1HLA-DQB1, CTLA4
20rheumatoid arthritis29.1FCGR2A, HLA-DQB1, CTLA4, IL10, LTA, TNFSF13B
21neonatal myasthenia gravis11.0
22juvenile myasthenia gravis10.8
23lambert-eaton myasthenic syndrome10.8
24pemphigus10.7
25thymic hyperplasia10.7
26lupus erythematosus10.6
27thyroiditis10.6
28pemphigus foliaceus10.6
29ophthalmoplegia10.6
30polyneuropathy10.6
31lambert syndrome10.6
32fetal akinesia deformation sequence10.5RAPSN
33muscular dystrophy10.5
34myasthenia gravis with thymus hyperplasia10.5
35alopecia10.5
36neuromyelitis optica10.5
37pure red-cell aplasia10.5
38demyelinating polyneuropathy10.5
39mediastinitis10.5
40myocarditis10.5
41myositis10.5
42rippling muscle disease10.5
43myasthenia gravis, neonatal transient10.5
44adult-onset myasthenia gravis10.5
45chronic inflammatory demyelinating polyneuropathy10.5
46facioscapulohumeral muscular dystrophy10.5
47internuclear ophthalmoplegia10.5
48cervicitis10.5
49encephalitis10.5
50hypothyroidism10.5

Graphical network of the top 20 diseases related to Myasthenia Gravis:



Diseases related to myasthenia gravis

Symptoms for Myasthenia Gravis

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Symptoms by clinical synopsis from OMIM:

159400

Clinical features from OMIM:

254200,159400,607085

HPO human phenotypes related to Myasthenia Gravis:

(show all 23)
id Description Frequency HPO Source Accession
1 ptosis HP:0000508
2 ophthalmoparesis HP:0000597
3 hashimoto thyroiditis HP:0000872
4 neoplasm HP:0002664
5 emg HP:0003403
6 fatigable weakness HP:0003473
7 type 2 muscle fiber atrophy HP:0003554
8 adult onset HP:0003581
9 sporadic HP:0003745
10 proximal amyotrophy HP:0007126
11 mildly elevated creatine phosphokinase HP:0008180
12 thymoma HP:0100522
13 ptosis HP:0000508
14 diplopia HP:0000651
15 abnormality of the endocrine system HP:0000818
16 dysarthria HP:0001260
17 nasal speech HP:0001611
18 dysphagia HP:0002015
19 autoimmunity HP:0002960
20 limb muscle weakness HP:0003690
21 proximal muscle weakness HP:0003701
22 facial palsy HP:0010628
23 thymoma HP:0100522

Drugs & Therapeutics for Myasthenia Gravis

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Drug clinical trials:

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Search NIH Clinical Center for Myasthenia Gravis

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myasthenia Gravis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myasthenia Gravis:
Hematopoietic stem cells for refractory myasthenia gravis
Embryonic/Adult Cultured Cells Related to Myasthenia Gravis:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Myasthenia Gravis

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Genetic tests related to Myasthenia Gravis:

id Genetic test Affiliating Genes
1 Myasthenia Gravis22

Anatomical Context for Myasthenia Gravis

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MalaCards organs/tissues related to Myasthenia Gravis:

32
Eye, Thymus, Skeletal muscle, T cells, B cells, Thyroid, Testes, Bone, Bone marrow, Heart, Lung, Neutrophil, Spleen, Brain, Kidney, Breast, Uterus, Prostate, Monocytes, Tongue, Pituitary

Animal Models for Myasthenia Gravis or affiliated genes

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Publications for Myasthenia Gravis

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Articles related to Myasthenia Gravis:

(show top 50)    (show all 1225)
idTitleAuthorsYear
1
Delivery of an miR155 inhibitor by anti-CD20 single chain antibody into B cells reduces the AChR-specific auto-antibodies and ameliorates experimental autoimmune myasthenia gravis. (24387321)
2014
2
Serum high mobility group box 1 is upregulated in myasthenia gravis. (25344065)
2014
3
Molecular docking cannot accurately predict drug off-target effects: Implications for the role of voriconazole in the exacerbation of myasthenia gravis. (24127354)
2014
4
Complete stable remission and autoantibody specificity in myasthenia gravis. (23255823)
2013
5
Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus. (22840813)
2013
6
Thymic tumours associated with Myasthenia gravis: a long term observation study of operated patients. (23944622)
2013
7
Leg pain in a patient with myasthenia gravis. (23613264)
2013
8
Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: A population-based cohort study. (24332676)
2013
9
Tuberculosis in myasthenia gravis. (23232007)
2013
10
Myasthenia gravis developing in an HIV-negative patient with Kaposi's sarcoma. (23010878)
2013
11
Surgical treatment of myasthenia gravis: evident benefits and insidious pitfalls of mini-invasive techniques. (24088481)
2013
12
Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase. (23535158)
2013
13
Chronic urticaria in myasthenia gravis patients - More than occasional coexistence? (23972403)
2013
14
An ocular form of myasthenia gravis with a high titer of anti-MuSK antibodies during a long-term follow-up. (23124154)
2012
15
Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. (22367834)
2012
16
Clinical significance of detection of antibodies to fetal and adult acetylcholine receptors in myasthenia gravis. (22961471)
2012
17
Castleman's Disease with Myasthenia Gravis. (22708092)
2012
18
Unilateral extended thoracoscopic thymectomy for nontumoral myasthenia gravis--a new standard. (22920527)
2012
19
Patient registries: useful tools for clinical research in myasthenia gravis. (23252904)
2012
20
Low-dose glucocorticoid therapy complements the pituitary-adrenocortical system and reduces anxiety and insomnia in myasthenia gravis patients. (22240858)
2012
21
Mosaic caveolin-3 expression in acquired rippling muscle disease without evidence of myasthenia gravis or acetylcholine receptor autoantibodies. (21295981)
2011
22
Robotic thymectomy for myasthenia gravis. (22042404)
2011
23
Investigation for RAPSN and DOK-7 mutations in a cohort of seronegative myasthenia gravis patients. (21305573)
2011
24
Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis. (22316202)
2011
25
A case of isolated plexiform neurofibroma in a patient with myasthenia gravis. (20548857)
2009
26
Juvenile myasthenia gravis. (19229875)
2009
27
Widely varying TNF-alpha levels in patients with myasthenia gravis. (19214380)
2009
28
ABCB1 polymorphisms may have a minor effect on ciclosporin blood concentrations in myasthenia gravis patients. (18717915)
2008
29
Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis. (17255332)
2007
30
Effect of sera from AChR-antibody negative myasthenia gravis patients on AChR and MuSK in cell cultures. (17335909)
2007
31
Acquired von Willebrand's syndrome in a patient with severe primary hypothyroidism associated with myasthenia gravis in the course of autoimmune polyglandular syndrome type 3. (17880463)
2007
32
Dandy-Walker syndrome in adult mimicking myasthenia gravis. (17420852)
2007
33
Myasthenia gravis masquerading as post-poliomyelitis syndrome. (16546772)
2006
34
Seronegative neonatal myasthenia gravis in one of the twins. (15475637)
2004
35
Acquired rippling muscle disease with myasthenia gravis. (14694511)
2004
36
Seronegative myasthenia gravis]. (15034472)
2004
37
Myasthenia gravis in individuals over 40. (14592910)
2003
38
Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis. (12707978)
2003
39
Stiff person syndrome and myasthenia gravis. (11960163)
2002
40
Major review: the clinical spectrum of pediatric myasthenia gravis: blepharoptosis, ophthalmoplegia and strabismus. A report of 14 cases. (12171588)
2002
41
Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. (11231638)
2001
42
Decreased mRNA expression of TNF-alpha and IL-10 in non-stimulated peripheral blood mononuclear cells in myasthenia gravis. (10809941)
2000
43
Cell-mediated immune response against titin in myasthenia gravis: evidence for the involvement of Th1 and Th2 cells. (9467662)
1998
44
FcgammaRIIA and FcgammaRIIIB polymorphisms in myasthenia gravis. (9521619)
1998
45
Myasthenia gravis sera containing antiryanodine receptor antibodies inhibit binding of [3H]-ryanodine to sarcoplasmic reticulum. (9486861)
1998
46
A patient with a relapse of myasthenia gravis after a 13-year remission following successful treatment by mediastinal irradiation and corticosteroid therapy]. (7605688)
1995
47
Transient neonatal myasthenia gravis and pyloric stenosis. (8534471)
1995
48
A novel HLA-DR4 allele (DRB1*0414) in a patient with myasthenia gravis. (1481204)
1992
49
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
50
Letter: Neonatal myasthenia gravis. (4448549)
1974

Variations for Myasthenia Gravis

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Expression for genes affiliated with Myasthenia Gravis

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Expression patterns in normal tissues for genes affiliated with Myasthenia Gravis

Search GEO for disease gene expression data for Myasthenia Gravis.

Pathways for genes affiliated with Myasthenia Gravis

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Pathways related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CHRNA1, CHRNG
29.8LTA, IL10
3
Show member pathways
9.6CHRNA1, CHRNG, ACHE
49.6RAPSN, CHRNA1, MUSK
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.4TNFRSF4, TNFSF13B
69.3IL10, LTA, TNFRSF4
7
Show member pathways
9.2RYR1, CHRNA1, LTA
8
Show member pathways
9.1CHRNA1, CHRNG, MUSK, RYR1
9
Show member pathways
9.0TNFSF13B, TNFRSF4, LTA
10
Show member pathways
8.9TNFSF13B, LTA, IL10, MUSK
118.8HLA-DQB1, FCGR2A, IL10
128.8FCGR2A, IL10, HLA-DQB1
13
Show member pathways
8.8FCGR2A, IL10, HLA-DQB1
14
Show member pathways
8.7LTA, TNFSF13B, IL10, TNFRSF4
158.7CTLA4, HLA-DQB1, TNFSF13B
16
Show member pathways
8.5TNFSF13B, TNFRSF4, MUSK, IL10, LTA
17
Show member pathways
8.5TNFRSF4, LTA, TNFSF13B, IL10, MUSK
18
Show member pathways
8.5TNFSF13B, MUSK, IL10, LTA, TNFRSF4
19
Show member pathways
8.2LTA, TNFSF13B, HLA-DQB1, TNFRSF4
20
Show member pathways
8.0LTA, IL10, CTLA4, HLA-DQB1, TNFSF13B

Compounds for genes affiliated with Myasthenia Gravis

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Compounds related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1edrophonium44 1111.4MUSK, ACHE
2gallamine44 2811.3CHRNA1, ACHE
3glatiramer acetate44 1111.1IL10, CTLA4
4toxin-14410.1LTA, IL10
5galantamine44 50 1112.1ACHE, CHRNG, CHRNA1
6indoleamine4410.1CTLA4, IL10
7cyclosporine50 1111.0LTA, IL10
8natalizumab44 1111.0FCGR2A, IL10
9adalimumab44 50 1111.9IL10, FCGR2A
10nicotine44 28 50 1112.9CHRNA1, ACHE, MUSK
11blys449.9TNFSF13B, IL10
12okt3449.9LTA, IL10
13enterotoxin449.9CTLA4, LTA
14con a449.9IL10, CTLA4
15propionate449.8IL10, RYR1
16mycophenolate mofetil44 50 1111.8LTA, IL10, CTLA4
17il 10449.8IL10, LTA, CTLA4
18succinylcholine44 50 28 1112.8CHRNA1, RYR1, ACHE
19lipoteichoic acid449.8LTA, IL10
20ryanodine44 28 6111.7RYR1, TTN, MUSK
21tgf beta1449.7LTA, IL10, CTLA4
22etanercept44 50 1111.7FCGR2A, IL10, LTA
23ivig449.6LTA, FCGR2A, IL10
24prednisolone44 28 1111.6IL10, LTA, FCGR2A
25tacrolimus44 50 1111.6RYR1, IL10, CTLA4
26digoxin44 61 50 24 1113.6IL10, RYR1
27rantes449.6CTLA4, LTA, IL10
28ecori449.5HLA-DQB1, LTA
29potassium44 24 1111.4TTN, RAPSN, RYR1, MUSK
30vitamin d449.4LTA, CTLA4, IL10
31ionomycin449.4LTA, CTLA4, IL10, TNFRSF4
32infliximab44 50 1111.3CTLA4, LTA, FCGR2A, IL10
33cyclosporin a44 28 6111.3TNFRSF4, CTLA4, IL10, LTA
34rituximab44 50 1110.8MUSK, TNFSF13B, IL10, CTLA4, FCGR2A
35threonine448.5FCGR2A, TTN, CTLA4, LTA
36lipid448.5RAPSN, RYR1, LTA, CTLA4, MUSK, FCGR2A
37serine448.4LTA, ACHE, CTLA4, RYR1, TTN, FCGR2A
38glutamate448.1HLA-DQB1, TTN, ACHE, CTLA4, LTA, RYR1
39tyrosine448.1LTA, RAPSN, MUSK, HLA-DQB1, FCGR2A, CTLA4
40acetylcholine44 50 28 24 1112.1CHRNA1, RAPSN, CTLA4, LTA, RYR1, MUSK
41calcium44 50 24 1110.5TNFSF13B, RYR1, TTN, FCGR2A, MUSK, RAPSN

GO Terms for genes affiliated with Myasthenia Gravis

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Cellular components related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:0058929.9CHRNA1, CHRNG
2neuromuscular junctionGO:0315949.5MUSK, CHRNA1, ACHE, RAPSN
3I bandGO:0316749.3TTN, RYR1
4postsynaptic membraneGO:0452119.2MUSK, RAPSN, ACHE, CHRNG, CHRNA1
5cell junctionGO:0300549.2RAPSN, MUSK, ACHE, CHRNA1, CHRNG
6Golgi apparatusGO:0057949.2TTN, ACHE, RAPSN, CTLA4
7integral component of plasma membraneGO:0058878.5TNFRSF4, MUSK, CHRNG, CTLA4, RYR1
8plasma membraneGO:0058866.8TNFSF13B, FCGR2A, CHRNA1, CHRNG, ACHE, CTLA4

Biological processes related to Myasthenia Gravis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.0RAPSN, ACHE
2negative regulation of B cell proliferationGO:03088910.0IL10, CTLA4
3negative regulation of growth of symbiont in hostGO:04413010.0IL10, LTA
4positive regulation of neuron apoptotic processGO:0435259.9RAPSN, MUSK
5negative regulation of T cell proliferationGO:0421309.8IL10, CTLA4
6neuromuscular junction developmentGO:0075289.8CHRNA1, MUSK
7regulation of protein kinase activityGO:0458599.7TNFRSF4, TTN
8muscle contractionGO:0069369.6RYR1, CHRNG, TTN
9synaptic transmissionGO:0072689.5CHRNA1, CHRNG, RAPSN, ACHE
10positive regulation of B cell proliferationGO:0308909.1TNFSF13B, TNFRSF4
11T cell costimulationGO:0312958.9CTLA4, TNFSF13B, HLA-DQB1
12immune responseGO:0069558.4TNFRSF4, TNFSF13B, HLA-DQB1, CTLA4

Molecular functions related to Myasthenia Gravis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine bindingGO:04216610.0CHRNA1, ACHE
2acetylcholine receptor activityGO:01546410.0CHRNG, CHRNA1
3acetylcholine-activated cation-selective channel activityGO:0048899.9CHRNG, CHRNA1
4protein self-associationGO:0436219.9ACHE, TTN
5tumor necrosis factor receptor bindingGO:0051649.1TNFSF13B, LTA
6cytokine activityGO:0051259.1LTA, IL10, TNFSF13B

Products for genes affiliated with Myasthenia Gravis

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Sources for Myasthenia Gravis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet