Myasthenia, Limb-girdle, Familial malady

MalaCards: Myasthenia, Limb-girdle, Familial, also known as myasthenias, is related to myasthenia gravis and congenital myasthenic syndrome. An important gene associated with Myasthenia, Limb-girdle, Familial is AGRN (agrin). Related mouse phenotype respiratory system.

OMIM: 254300

myasthenia, limb-girdle, familial 33 myasthenias 43

Diseases related to myasthenia, limb-girdle, familial by text searches and GeneDecks gene sharing:

(show top 50)    (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	myasthenia gravis	37.3	AGRN, DOK7
2	congenital myasthenic syndrome	30.0	DOK7, AGRN
3	neuropathy	25.6	DOK7, AGRN
4	myopathy	25.2	DOK7, AGRN
5	myasthenia	12.7
6	thymoma	9.7
7	neonatal myasthenia gravis	7.5
8	multiple sclerosis	7.3
9	myasthenia gravis with thymus hyperplasia	6.8
10	myasthenia gravis congenital	6.8
11	myasthenia gravis, limb-girdle	6.8
12	myasthenia, limb-girdle, with tubular aggregates	6.4
13	myasthenia, familial infantile, 1	6.4
14	myasthenia gravis, neonatal transient	6.4
15	antiphospholipid syndrome	5.9
16	congenital myasthenic syndrome with episodic apnea	5.9
17	connective tissue disease	5.9
18	carcinoma	5.9
19	hepatitis c	5.9
20	hepatitis	5.9
21	myositis	5.9
22	myasthenic syndrome	5.9
23	thymic epithelial tumor	5.9
24	chordoma	5.0
25	pemphigus	5.0
26	crohn's disease	5.0
27	pancreatitis	5.0
28	diabetes mellitus	5.0
29	pneumonia	5.0
30	dysphagia	5.0
31	paraneoplastic neurologic disorders	5.0
32	graves' disease	5.0
33	paraneoplastic syndromes	5.0
34	lambert-eaton myasthenic syndrome	5.0
35	peripheral neuropathy	5.0
36	muscular atrophy	5.0
37	rhabdomyosarcoma	5.0
38	mixed connective tissue disease	5.0
39	rheumatoid arthritis	5.0
40	myoepithelioma	5.0
41	renal cell carcinoma	5.0
42	respiratory failure	5.0
43	myotonic dystrophy	5.0
44	spinal-bulbar muscular atrophy	5.0
45	myotonic dystrophy type 1	5.0
46	thymus cancer	5.0
47	agrn-related congenital myasthenic syndrome	5.0
48	neuromuscular disease	5.0
49	thymic hyperplasia	5.0
50	arthritis	5.0

Clinical features from OMIM: 254300

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to myasthenia, limb-girdle, familial:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.1	DOK7, AGRN

Genes related to myasthenia, limb-girdle, familial according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	AGRN	agrin	11.1
2	DOK7	docking protein 7	11.1

Biological processes related to myasthenia, limb-girdle, familial according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor clustering	GO:043113	9.1	DOK7, AGRN