MCID: MYC012
MIFTS: 46

Mycetoma

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Mycetoma

MalaCards integrated aliases for Mycetoma:

Name: Mycetoma 49 55 69
Madura Foot 49 55
Mycetoma of Foot 69

Characteristics:

Orphanet epidemiological data:

55
mycetoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Orphanet 55 ORPHA2583
MESH via Orphanet 42 D008271
UMLS via Orphanet 70 C0024449
ICD10 via Orphanet 33 B47.0 B47.1 B47.9
ICD10 32 B47 B47.9
UMLS 69 C2355609

Summaries for Mycetoma

NIH Rare Diseases : 49 Mycetoma is a chronic infection that is caused by fungi or actinomycetes (bacteria that produce filaments, like fungi). The first symptom of the condition is generally painless swelling beneath the skin, which progresses to a nodule (lump) over several years. Eventually, affected people experience massive swelling and hardening of the affected area; skin rupture; and formation of sinus tracts (holes) that discharge pus and grains filled with organisms. Some affected people have no discomfort while others report itching and/or pain. Mycetoma is rare in the United States, but is commonly diagnosed in Africa, Mexico and India. In these countries, it occurs most frequently in farmers, shepherds, and people living in rural areas. Frequent exposure to penetrating wounds by thorns or splinters is a risk factor. Treatment varies based on the cause of the condition and may include antibiotics or antifungal medications. Last updated: 12/4/2015

MalaCards based summary : Mycetoma, also known as madura foot, is related to eumycotic mycetoma and pneumonia. An important gene associated with Mycetoma is CHIT1 (Chitinase 1), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Insulin receptor recycling. The drugs Miconazole and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone.

Related Diseases for Mycetoma

Diseases related to Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 eumycotic mycetoma 33.4 CCL5 CR1 TPT1
2 pneumonia 29.3 CCL5 CXCL8 IL10
3 lung disease 29.2 CCL5 CXCL8 IL10 MMP9
4 actinomycosis 11.3
5 hemorrhoid 10.4 MMP9 NOS2
6 ross river fever 10.4 COMT IL10
7 internal hemorrhoid 10.4 MMP9 NOS2
8 filariasis 10.3 CCL5 CHIT1 IL10
9 idiopathic achalasia 10.3 IL10 NOS2
10 tropical spastic paraparesis 10.3 CCL5 IL10 MMP9
11 relapsing-remitting multiple sclerosis 10.3 CCL5 IL10 MMP9
12 demyelinating disease 10.2 CCL5 IL10 MMP9
13 vibratory urticaria 10.2 CXCL8 MMP9
14 tungiasis 10.1 CXCL8 IL10
15 scabies 10.1 CXCL8 IL10
16 pouchitis 10.1 CXCL8 IL10
17 testicular leydig cell tumor 10.1 CYP17A1 HSD3B1
18 necatoriasis 10.1 CXCL8 IL10
19 orofacial granulomatosis 10.1 CCL5 IL10
20 transsexualism 10.1 CYP17A1 CYP19A1
21 vulvovaginitis 10.1 CCL5 CXCL8 IL10
22 funisitis 10.0 CXCL8 IL10
23 viral encephalitis 10.0 CCL5 CXCL8 IL10
24 extrinsic allergic alveolitis 10.0 CCL5 CXCL8 IL10
25 spinal cord injury 10.0 CXCL8 MMP9 NOS2
26 acute transverse myelitis 10.0 CXCL8 IL10 MMP9
27 cryptogenic organizing pneumonia 10.0 CXCL8 MMP9
28 transverse myelitis 10.0 CXCL8 IL10 MMP9
29 bronchial disease 10.0 CCL5 CXCL8 IL10
30 mycobacterium tuberculosis 1 10.0
31 trichuriasis 10.0 CXCL8 IL10
32 helicobacter pylori infection 10.0 CCL5 CXCL8 IL10
33 appendicitis 10.0 CXCL8 IL10 MMP9
34 bronchiolitis 10.0 CCL5 CXCL8 IL10
35 bronchiolitis obliterans 10.0 CXCL8 IL10 MMP9
36 trypanosomiasis 10.0 CCL5 CXCL8 IL10
37 chlamydia 10.0 CXCL8 IL10 NOS2
38 bacterial meningitis 10.0 CXCL8 IL10 MMP9
39 allergic asthma 10.0 CCL5 CXCL8 IL10
40 chagas disease 10.0 CXCL8 IL10 NOS2
41 meningitis 10.0 CXCL8 IL10 MMP9
42 periodontitis 10.0 CXCL8 IL10 MMP9
43 allergic hypersensitivity disease 10.0 CCL5 CSN1S1 IL10 TPT1
44 periapical granuloma 9.9 CCL5 CXCL8
45 leiomyoma, uterine 9.9 COMT CYP17A1 CYP19A1
46 viral infectious disease 9.9 CCL5 CXCL8 IL10
47 multiple sclerosis 9.9 CCL5 CHIT1 IL10 MMP9 NOS2
48 clonorchiasis 9.9 CXCL8 IL10
49 aspergillosis 9.9
50 cerebritis 9.9

Graphical network of the top 20 diseases related to Mycetoma:



Diseases related to Mycetoma

Symptoms & Phenotypes for Mycetoma

Drugs & Therapeutics for Mycetoma

Drugs for Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
2
Itraconazole Approved, Investigational Phase 4,Phase 2 84625-61-6 55283
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4 Hydroxyitraconazole Phase 4,Phase 2
5 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
6 Steroid Synthesis Inhibitors Phase 4,Phase 2
7 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
9 Hormone Antagonists Phase 4,Phase 2
10 Hormones Phase 4,Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
12 Anti-Infective Agents Phase 4,Phase 2
13 Antifungal Agents Phase 4,Phase 2
14 Antitussive Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
2 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Mycetoma

Genetic Tests for Mycetoma

Anatomical Context for Mycetoma

MalaCards organs/tissues related to Mycetoma:

38
Skin, Lung, Bone, Kidney, Heart, Prostate, Pituitary

Publications for Mycetoma

Articles related to Mycetoma:

(show top 50) (show all 570)
# Title Authors Year
1
Case 249: Intramuscular Mycetoma. ( 29261466 )
2018
2
Metastatic Cancer Mimicking a Mycetoma. ( 28207281 )
2017
3
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. ( 28192433 )
2017
4
Molecular identification of unusual Mycetoma agents isolated from patients in Venezuela. ( 27766680 )
2017
5
Persistent Hemoptysis in an Elderly Patient with Pseudoallescheria boydii Mycetoma. ( 28336056 )
2017
6
Scedosporium apiospermum Mycetoma in an Immunocompetent Patient without Prior Lung Disease. ( 28035880 )
2017
7
Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature. ( 28410611 )
2017
8
Mycetoma laboratory diagnosis: Review article. ( 28837657 )
2017
9
Unusual Presentation of Mycetoma of the Foot: A Rare Case Report. ( 28630831 )
2017
10
Rapid and Robust Identification of the Agents of Black-Grain Mycetoma by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. ( 28592546 )
2017
11
Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16-year-old Fjord pony gelding with pituitary pars intermedia dysfunction. ( 28736852 )
2017
12
Mycetoma: A global medical and socio-economic dilemma. ( 28426654 )
2017
13
Mycetoma: An Update. ( 28794542 )
2017
14
Mycetoma in a non-endemic area: a diagnostic challenge. ( 28167862 )
2017
15
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
16
Post-tuberculosis mycetoma: bronchoscopic removal. ( 28580148 )
2017
17
Images in COPD: Bullous Emphysema with Mycetoma. ( 28848927 )
2017
18
Mycetoma (Madura Foot) in Israel: Recent Cases and a Systematic Review of the Literature. ( 28719270 )
2017
19
Closing the mycetoma knowledge gap. ( 28992217 )
2017
20
Aspergillus Mycetoma Causing Epiphora and Ipsilateral Facial Pain. ( 27046035 )
2016
21
Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease. ( 27022493 )
2016
22
Mycetoma: A Long Journey from Neglect. ( 26797103 )
2016
23
Eyelid Mycetoma Masquerading as Sebaceous Carcinoma. ( 26882058 )
2016
24
Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication. ( 27442512 )
2016
25
Predictors of Post-operative Mycetoma Recurrence Using Machine-Learning Algorithms: The Mycetoma Research Center Experience. ( 27798643 )
2016
26
Mycetoma. ( 27559532 )
2016
27
A case of Aspergillus nidulans causing white granule mycetoma. ( 26900232 )
2016
28
The Surgical Treatment of Mycetoma. ( 27336736 )
2016
29
Genome Sequence of Madurella mycetomatis mm55, Isolated from a Human Mycetoma Case in Sudan. ( 27231361 )
2016
30
Role of a NSAID in the apparent cure of a fungal mycetoma. ( 27233662 )
2016
31
Hand Mycetoma: The Mycetoma Research Centre Experience and Literature Review. ( 27483367 )
2016
32
Mycetoma: a unique neglected tropical disease. ( 26738840 )
2016
33
Starting from scratch-the unique neglect of mycetoma. ( 27684346 )
2016
34
Mycetoma Pulmonary Secondaries from a Gluteal Eumycetoma: An Unusual Presentation. ( 27711109 )
2016
35
Successful living-donor liver transplantation after treatment of sinus aspergillosis by endoscopic mycetoma removal and sinus drainage. ( 26943397 )
2015
36
Application of Isothermal Amplification Techniques for Identification of Madurella mycetomatis, the Prevalent Agent of Human Mycetoma. ( 26246484 )
2015
37
A rare case of mycetoma due to curvularia. ( 25949061 )
2015
38
Amphotericin B but not itraconazole is able to prevent grain formation in experimental Madurella mycetomatis mycetoma in mice. ( 26150103 )
2015
39
Gunpowder or Mycetoma? ( 25911568 )
2015
40
A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma--A Retrospective Study. ( 26332238 )
2015
41
Mycetoma of the Foot Caused by Madurella Mycetomatis in Immigrants from Sudan. ( 26357716 )
2015
42
Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan. ( 25816316 )
2015
43
Head and neck mycetoma: the mycetoma research centre experience. ( 25768090 )
2015
44
Mycetoma of the foot--diagnosis of the etiologic agent and surgical treatment. ( 26157078 )
2015
45
Revisiting antiseptic use in reducing post-surgical recurrence in mycetoma. ( 26036161 )
2015
46
Does the benefit of salvage amputation always outweigh disability in drug-failure mycetoma?: a tale of two cases. ( 25657401 )
2015
47
Mycetoma, Mycoses and Pregnancy. ( 25518866 )
2015
48
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2015
49
Pseudotumoral presentation of fungating mycetoma caused by Phaeoacremonium fuscum in a renal transplant patient. ( 26433132 )
2015
50
Paradoxical response preceding control of Scedosporium apiospermum mycetoma with posaconazole treatment. ( 26114987 )
2015

Variations for Mycetoma

Expression for Mycetoma

Search GEO for disease gene expression data for Mycetoma.

Pathways for Mycetoma

Pathways related to Mycetoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 CCL5 CXCL8 IL10 NOS2
2
Show member pathways
12.28 CCL5 CXCL8 CXCR2 NOS2
3
Show member pathways
12.14 CCL5 CXCL8 CXCR2 NOS2
4 11.84 CXCL8 MMP9 NOS2
5
Show member pathways
11.82 CCL5 CXCL8 CXCR2
6 11.71 CXCL8 IL10 NOS2
7 11.68 CXCL8 IL10 MMP9 NOS2
8
Show member pathways
11.64 CYP17A1 CYP19A1 HSD3B1
9 11.57 CXCL8 IL10 NOS2
10 11.47 CR1 IL10 NOS2
11 11.43 CCL5 CXCL8 MMP9
12
Show member pathways
11.41 CXCL8 MMP9 NOS2
13
Show member pathways
11.29 COMT CYP17A1 CYP19A1 HSD3B1
14 11.27 CCL5 CXCL8 IL10
15 11.16 CYP17A1 CYP19A1 CYP1B1 HSD3B1
16
Show member pathways
11.08 COMT CYP19A1 CYP1B1
17 10.95 CR1 CXCL8 IL10 THBS4
18
Show member pathways
10.83 COMT CYP17A1 CYP19A1 CYP1B1 HSD3B1
19 10.8 CCL5 MMP9

GO Terms for Mycetoma

Cellular components related to Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL5 CHIT1 CXCL8 IL10 MMP9 THBS4

Biological processes related to Mycetoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.97 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 inflammatory response GO:0006954 9.9 CCL5 CXCL8 CXCR2 IL10
3 positive regulation of angiogenesis GO:0045766 9.76 CXCL8 CXCR2 CYP1B1
4 cellular response to lipopolysaccharide GO:0071222 9.74 CXCL8 IL10 NOS2
5 chemokine-mediated signaling pathway GO:0070098 9.61 CCL5 CXCL8 CXCR2
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.59 IL10 MMP9
7 positive regulation of JAK-STAT cascade GO:0046427 9.56 CCL5 CYP1B1
8 dendritic cell chemotaxis GO:0002407 9.55 CCL5 CXCR2
9 estrogen metabolic process GO:0008210 9.54 COMT CYP1B1
10 neutrophil chemotaxis GO:0030593 9.54 CCL5 CXCL8 CXCR2
11 nitric oxide biosynthetic process GO:0006809 9.52 CYP1B1 NOS2
12 response to molecule of bacterial origin GO:0002237 9.51 CXCL8 IL10
13 steroid biosynthetic process GO:0006694 9.5 CYP17A1 CYP19A1 HSD3B1
14 estrogen biosynthetic process GO:0006703 9.49 CYP19A1 HSD3B1
15 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.48 CCL5 CXCL8
16 androgen biosynthetic process GO:0006702 9.46 CYP17A1 HSD3B1
17 glucocorticoid biosynthetic process GO:0006704 9.4 CYP17A1 HSD3B1
18 positive regulation of neutrophil chemotaxis GO:0090023 9.33 CXCL8 CXCR2 THBS4
19 endothelial cell-cell adhesion GO:0071603 9.26 CYP1B1 THBS4
20 sterol metabolic process GO:0016125 9.13 CYP17A1 CYP19A1 CYP1B1
21 neutrophil activation GO:0042119 8.8 CCL5 CXCL8 CXCR2

Molecular functions related to Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.72 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP17A1 CYP19A1 CYP1B1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP19A1 CYP1B1
4 oxygen binding GO:0019825 9.33 CYP17A1 CYP19A1 CYP1B1
5 iron ion binding GO:0005506 9.26 CYP17A1 CYP19A1 CYP1B1 NOS2
6 heme binding GO:0020037 8.92 CYP17A1 CYP19A1 CYP1B1 NOS2

Sources for Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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