MCID: MYC012
MIFTS: 43

Mycetoma

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Mycetoma

MalaCards integrated aliases for Mycetoma:

Name: Mycetoma 50 56 69
Madura Foot 50 56
Mycetoma of Foot 69

Characteristics:

Orphanet epidemiological data:

56
mycetoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Orphanet 56 ORPHA2583
MESH via Orphanet 43 D008271
UMLS via Orphanet 70 C0024449
ICD10 via Orphanet 34 B47.0 B47.1 B47.9
ICD10 33 B47 B47.9

Summaries for Mycetoma

NIH Rare Diseases : 50 mycetoma is a chronic infection that is caused by fungi or actinomycetes (bacteria that produce filaments, like fungi). the first symptom of the condition is generally painless swelling beneath the skin, which progresses to a nodule (lump) over several years. eventually, affected people experience massive swelling and hardening of the affected area; skin rupture; and formation of sinus tracts (holes) that discharge pus and grains filled with organisms. some affected people have no discomfort while others report itching and/or pain. mycetoma is rare in the united states, but is commonly diagnosed in africa, mexico and india. in these countries, it occurs most frequently in farmers, shepherds, and people living in rural areas. frequent exposure to penetrating wounds by thorns or splinters is a risk factor. treatment varies based on the cause of the condition and may include antibiotics or antifungal medications. last updated: 12/4/2015

MalaCards based summary : Mycetoma, also known as madura foot, is related to eumycotic mycetoma and actinomycosis. An important gene associated with Mycetoma is CHIT1 (Chitinase 1), and among its related pathways/superpathways are Insulin receptor recycling and Immune response CCR3 signaling in eosinophils. The drugs Guaifenesin and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone.

Wikipedia : 72 Mycetoma is a term for a chronic subcutaneous infection, a type of granulomatous infection. It is... more...

Related Diseases for Mycetoma

Diseases related to Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
id Related Disease Score Top Affiliating Genes
1 eumycotic mycetoma 12.4
2 actinomycosis 11.2
3 emphysematous cholecystitis 10.6 MMP9 NOS2
4 balkan hemorrhagic fever 10.6 COMT IL10
5 xanthogranulomatous cholecystitis 10.6 MMP9 NOS2
6 gastric ulcer 10.5 CCL5 CHIT1 IL10
7 idiopathic dilatation of the pulmonary artery 10.5 IL10 NOS2
8 myelitis 10.5 CCL5 IL10 MMP9
9 neonatal jaundice 10.4 CCL5 IL10 MMP9
10 causalgia 10.4 CCL5 IL10 MMP9
11 ichthyosis, congenital, autosomal recessive 12 10.3 CXCL8 MMP9
12 basidiobolomycosis 10.3 CXCL8 IL10
13 lymph node palisaded myofibroblastoma 10.3 CXCL8 IL10
14 congenital insensitivity to pain with hyperhidrosis 10.2 CXCL8 IL10
15 nonspecific interstitial pneumonia 10.2 CXCL8 IL10
16 mediastinum neurofibroma 10.2 CSN1S1 IL10 TPT1
17 pulmonary blastoma 10.2 CYP17A1 HSD3B1
18 gastrojejunal ulcer 10.2 CYP17A1 CYP19A1
19 hidradenitis suppurativa 10.1 CCL5 CXCL8 IL10
20 myofascial pain syndrome 10.1 CCL5 CXCL8 IL10
21 dysphagia 10.1 CCL5 CXCL8 IL10
22 ovarian mucinous adenofibroma 10.1 CCL5 CXCL8 IL10
23 carcinoma arising in nasal papillomatosis 10.1 CCL5 CXCL8 IL10
24 spinal stenosis 10.1 CXCL8 MMP9 NOS2
25 infancy electroclinical syndrome 10.1 CXCL8 IL10
26 drug rash with eosinophilia and systemic symptoms 10.1 CXCL8 IL10 MMP9
27 spontaneous ocular nystagmus 10.1 CCL5 CXCL8 IL10
28 tricho onychic dysplasia 10.1 CXCL8 IL10 MMP9
29 tarsal tunnel syndrome 10.1 CXCL8 IL10
30 endocervical type cervical mucinous adenocarcinoma 10.1 CXCL8 IL10 MMP9
31 inner ear disease 10.1 CCL5 CXCL8 IL10
32 burn scar 10.1 CXCL8 IL10 MMP9
33 hyperpigmentation of eyelid 10.1 CCL5 CXCL8 IL10
34 mucocutaneous leishmaniasis 10.1 CXCL8 IL10 NOS2
35 tuberculous salpingitis 10.1 CXCL8 MMP9
36 urofacial syndrome 1 10.1 CXCL8 IL10
37 sheehan syndrome 10.1 CXCL8 IL10 MMP9
38 keratomalacia 10.1 CXCL8 IL10 NOS2
39 intracranial hypertension 10.0 CCL5 CXCL8 IL10
40 optic nerve hypoplasia 10.0 CXCL8 IL10 MMP9
41 detrusor sphincter dyssynergia 10.0 CXCL8 IL10 NOS2
42 vulva fibroepithelial polyp 10.0 CXCL8 IL10 MMP9
43 pulmonary embolism 10.0 CXCL8 IL10 MMP9
44 advanced sleep phase syndrome, familial, 1 10.0 CCL5 CHIT1 IL10 MMP9 NOS2
45 oropharyngeal cancer, childhood 10.0 CCL5 IL10
46 carotid artery dissection 10.0 CCL5 CXCL8 IL10
47 adenoid squamous cell carcinoma 10.0 CCL5 CXCL8 IL10
48 vallecula cancer 10.0 COMT CXCL8 IL10
49 breast papillary carcinoma 9.9 CXCL8 CXCR2 IL10
50 plantar wart 9.9 CXCL8 IL10

Graphical network of the top 20 diseases related to Mycetoma:



Diseases related to Mycetoma

Symptoms & Phenotypes for Mycetoma

Drugs & Therapeutics for Mycetoma

Drugs for Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
2
Itraconazole Approved, Investigational Phase 4,Phase 2 84625-61-6 55283
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
4 Antifungal Agents Phase 4,Phase 2
5 Anti-Infective Agents Phase 4,Phase 2
6 Antitussive Agents Phase 4
7 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
8 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
10 Hormone Antagonists Phase 4,Phase 2
11 Hormones Phase 4,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
13 Hydroxyitraconazole Phase 4,Phase 2
14 Steroid Synthesis Inhibitors Phase 4,Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
2 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Mycetoma

Genetic Tests for Mycetoma

Anatomical Context for Mycetoma

MalaCards organs/tissues related to Mycetoma:

39
Skin, Lung, Bone, Kidney, Heart, Prostate, Pituitary

Publications for Mycetoma

Articles related to Mycetoma:

(show top 50) (show all 568)
id Title Authors Year
1
Scedosporium apiospermum Mycetoma in an Immunocompetent Patient without Prior Lung Disease. ( 28035880 )
2017
2
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. ( 28192433 )
2017
3
Post-tuberculosis mycetoma: bronchoscopic removal. ( 28580148 )
2017
4
Molecular identification of unusual Mycetoma agents isolated from patients in Venezuela. ( 27766680 )
2017
5
Mycetoma (Madura Foot) in Israel: Recent Cases and a Systematic Review of the Literature. ( 28719270 )
2017
6
Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature. ( 28410611 )
2017
7
Mycetoma laboratory diagnosis: Review article. ( 28837657 )
2017
8
Metastatic Cancer Mimicking a Mycetoma. ( 28207281 )
2017
9
Rapid and Robust Identification of the Agents of Black-Grain Mycetoma by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. ( 28592546 )
2017
10
Mycetoma: An Update. ( 28794542 )
2017
11
Mycetoma in a non-endemic area: a diagnostic challenge. ( 28167862 )
2017
12
Persistent Hemoptysis in an Elderly Patient with Pseudoallescheria boydii Mycetoma. ( 28336056 )
2017
13
Unusual Presentation of Mycetoma of the Foot: A Rare Case Report. ( 28630831 )
2017
14
Mycetoma: A global medical and socio-economic dilemma. ( 28426654 )
2017
15
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
16
Images in COPD: Bullous Emphysema with Mycetoma. ( 28848927 )
2017
17
Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16-year-old Fjord pony gelding with pituitary pars intermedia dysfunction. ( 28736852 )
2017
18
Mycetoma: a unique neglected tropical disease. ( 26738840 )
2016
19
Predictors of Post-operative Mycetoma Recurrence Using Machine-Learning Algorithms: The Mycetoma Research Center Experience. ( 27798643 )
2016
20
Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication. ( 27442512 )
2016
21
Aspergillus Mycetoma Causing Epiphora and Ipsilateral Facial Pain. ( 27046035 )
2016
22
Eyelid Mycetoma Masquerading as Sebaceous Carcinoma. ( 26882058 )
2016
23
Mycetoma: A Long Journey from Neglect. ( 26797103 )
2016
24
Mycetoma Pulmonary Secondaries from a Gluteal Eumycetoma: An Unusual Presentation. ( 27711109 )
2016
25
The Surgical Treatment of Mycetoma. ( 27336736 )
2016
26
Starting from scratch-the unique neglect of mycetoma. ( 27684346 )
2016
27
Role of a NSAID in the apparent cure of a fungal mycetoma. ( 27233662 )
2016
28
Mycetoma. ( 27559532 )
2016
29
Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease. ( 27022493 )
2016
30
Genome Sequence of Madurella mycetomatis mm55, Isolated from a Human Mycetoma Case in Sudan. ( 27231361 )
2016
31
Hand Mycetoma: The Mycetoma Research Centre Experience and Literature Review. ( 27483367 )
2016
32
A case of Aspergillus nidulans causing white granule mycetoma. ( 26900232 )
2016
33
Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan. ( 25816316 )
2015
34
Mycetoma of the foot--diagnosis of the etiologic agent and surgical treatment. ( 26157078 )
2015
35
Revisiting antiseptic use in reducing post-surgical recurrence in mycetoma. ( 26036161 )
2015
36
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2015
37
Successful living-donor liver transplantation after treatment of sinus aspergillosis by endoscopic mycetoma removal and sinus drainage. ( 26943397 )
2015
38
Mycetoma: an old and still neglected tropical disease. ( 25667234 )
2015
39
Mycetoma of the Foot Caused by Madurella Mycetomatis in Immigrants from Sudan. ( 26357716 )
2015
40
Gunpowder or Mycetoma? ( 25911568 )
2015
41
A rare case of mycetoma due to curvularia. ( 25949061 )
2015
42
Mycetoma Caused by Aspergillus nidulans. ( 26014969 )
2015
43
Mycetoma, Mycoses and Pregnancy. ( 25518866 )
2015
44
Does the benefit of salvage amputation always outweigh disability in drug-failure mycetoma?: a tale of two cases. ( 25657401 )
2015
45
Paradoxical response preceding control of Scedosporium apiospermum mycetoma with posaconazole treatment. ( 26114987 )
2015
46
Head and neck mycetoma: the mycetoma research centre experience. ( 25768090 )
2015
47
Pseudotumoral presentation of fungating mycetoma caused by Phaeoacremonium fuscum in a renal transplant patient. ( 26433132 )
2015
48
Amphotericin B but not itraconazole is able to prevent grain formation in experimental Madurella mycetomatis mycetoma in mice. ( 26150103 )
2015
49
A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma--A Retrospective Study. ( 26332238 )
2015
50
Application of Isothermal Amplification Techniques for Identification of Madurella mycetomatis, the Prevalent Agent of Human Mycetoma. ( 26246484 )
2015

Variations for Mycetoma

Expression for Mycetoma

Search GEO for disease gene expression data for Mycetoma.

Pathways for Mycetoma

Pathways related to Mycetoma according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 CCL5 CXCL8 CXCR2 NOS2
2
Show member pathways
12.14 CCL5 CXCL8 CXCR2 NOS2
3 11.83 CXCL8 MMP9 NOS2
4
Show member pathways
11.83 CCL5 CXCL8 CXCR2
5 11.71 CXCL8 IL10 NOS2
6 11.68 CXCL8 IL10 MMP9 NOS2
7
Show member pathways
11.64 CYP17A1 CYP19A1 HSD3B1
8 11.57 CXCL8 IL10 NOS2
9 11.5 CR1 IL10 NOS2
10 11.43 CCL5 CXCL8 MMP9
11
Show member pathways
11.41 CXCL8 MMP9 NOS2
12
Show member pathways
11.29 COMT CYP17A1 CYP19A1 HSD3B1
13 11.27 CCL5 CXCL8 IL10
14 11.16 CYP17A1 CYP19A1 CYP1B1 HSD3B1
15
Show member pathways
11.08 COMT CYP19A1 CYP1B1
16 10.95 CR1 CXCL8 IL10 THBS4
17
Show member pathways
10.83 COMT CYP17A1 CYP19A1 CYP1B1 HSD3B1
18 10.79 CCL5 MMP9

GO Terms for Mycetoma

Cellular components related to Mycetoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL5 CHIT1 CXCL8 IL10 MMP9 THBS4

Biological processes related to Mycetoma according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.97 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 inflammatory response GO:0006954 9.88 CCL5 CXCL8 CXCR2 IL10
3 cellular response to lipopolysaccharide GO:0071222 9.73 CXCL8 IL10 NOS2
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 IL10 MMP9
5 chemokine-mediated signaling pathway GO:0070098 9.58 CCL5 CXCL8 CXCR2
6 positive regulation of JAK-STAT cascade GO:0046427 9.55 CCL5 CYP1B1
7 dendritic cell chemotaxis GO:0002407 9.54 CCL5 CXCR2
8 nitric oxide biosynthetic process GO:0006809 9.52 CYP1B1 NOS2
9 response to molecule of bacterial origin GO:0002237 9.51 CXCL8 IL10
10 neutrophil chemotaxis GO:0030593 9.5 CCL5 CXCL8 CXCR2
11 estrogen biosynthetic process GO:0006703 9.49 CYP19A1 HSD3B1
12 estrogen metabolic process GO:0008210 9.48 COMT CYP1B1
13 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.46 CCL5 CXCL8
14 androgen biosynthetic process GO:0006702 9.43 CYP17A1 HSD3B1
15 steroid biosynthetic process GO:0006694 9.43 CYP17A1 CYP19A1 HSD3B1
16 glucocorticoid biosynthetic process GO:0006704 9.37 CYP17A1 HSD3B1
17 endothelial cell-cell adhesion GO:0071603 9.16 CYP1B1 THBS4
18 sterol metabolic process GO:0016125 9.13 CYP17A1 CYP19A1 CYP1B1
19 neutrophil activation GO:0042119 8.8 CCL5 CXCL8 CXCR2

Molecular functions related to Mycetoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.72 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP17A1 CYP19A1 CYP1B1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP19A1 CYP1B1
4 oxygen binding GO:0019825 9.33 CYP17A1 CYP19A1 CYP1B1
5 iron ion binding GO:0005506 9.26 CYP17A1 CYP19A1 CYP1B1 NOS2
6 heme binding GO:0020037 8.92 CYP17A1 CYP19A1 CYP1B1 NOS2

Sources for Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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