Mycobacterial Infection malady

MedlinePlus: Mycobacteria are a type of germ. there are many different kinds. the most common one causes tuberculosis. another one causes leprosy. still others cause infections that are called atypical mycobacterial infections. they aren't "typical" because they don't cause tuberculosis. but they can still harm people, especially people with other problems that affect their immunity, such as aids. sometimes you can have these infections with no symptoms at all. at other times, they can cause lung symptoms similar to tuberculosis: cough weight loss coughing up blood or mucus weakness or fatigue fever and chills night sweats lack of appetite and weight loss medicines can treat these infections, but often more than one is needed to cure the infection.²³

MalaCards: Mycobacterial Infection, also known as mycobacterial infections, is related to atypical mycobacteriosis, familial and interferon gamma, receptor 1, deficiency. An important gene associated with Mycobacterial Infection is IFNGR2 (interferon gamma receptor 2 (interferon gamma transducer 1)), and among its related pathways are Bacterial infections in CF airways and Leishmaniasis. The drugs amikacin and amikacin sulfate and the compounds endotoxin and flagellin have been mentioned in the context of this disorder. Affiliated tissues include lung and t cells, and related mouse phenotypes are respiratory system and renal/urinary system.

mycobacterial infection 7 32 mycobacterial infections 23

mycobacterium infections 43

Diseases related to mycobacterial infection by text searches and GeneDecks gene sharing:

(show top 50)    (show all 605)

id	Related Disease	Score	Top Affiliating Genes
1	atypical mycobacteriosis, familial	32.0	IFNGR1, IFNGR2, STAT1
2	interferon gamma, receptor 1, deficiency	29.6	IFNG, IFNGR1
3	bronchiectasis	27.0	SERPINA1, CFTR, IL10, IL6, MBL2, IFNG
4	immunodeficiency	24.1	CIITA, CD209, IL10, IL15, IL18, IL2
5	cystic fibrosis	22.5	PIK3CG, SERPINA1, CFTR, IL10, IL18, IL2
6	fibrosis	20.7	PIK3CG, SERPINA1, CLEC12A, CFTR, CD209, IL10
7	cutaneous leishmaniasis	13.7	IL10, IFNG
8	tuberculous uveitis	13.6	IFNG, TNF
9	mycobacterium tuberculosis	13.6	CD209, TNF, SLC11A1
10	stachybotrys chartarum	13.6	IL18, CCL4, CCL3
11	punctate inner choroidopathy	13.6	IL10, TNF
12	pleural tuberculosis	13.6	IL18, CCL3, IFNG
13	buruli ulcer disease	13.6	IL10, IFNG
14	miliary tuberculosis	13.6	IL10, IL18, IFNG
15	tuberculoid leprosy	13.6	IL10, IFNG
16	invasive aspergillosis	13.6	TLR2, TLR4
17	african tick-bite fever	13.6	IL10, CCL3, IFNG
18	relapsing polychondritis	13.6	IL10, CCL4, IFNG
19	vulvovaginal candidiasis	13.6	IL4, MBL2, DEFB4A
20	urinary schistosomiasis	13.6	IL10, IL4, IFNG
21	intermediate uveitis	13.5	IL10, IFNG, TNF
22	campylobacteriosis	13.5	IFNG, TLR4, STAT1, SLC11A1
23	primary systemic mycosis	13.5	IL10, IL4, TNF
24	paratyphoid fever	13.5	IL12B, IFNG, IFNGR1, TNF
25	bacterial meningitis	13.5	CCL4, CCL3, TLR2
26	dengue disease	13.5	CD209, MBL2, TNF
27	scleritis	13.5	IL4, IFNG, TNF
28	visceral leishmaniasis	13.5	IL10, IL4, IFNG, SLC11A1
29	colorectal cancer	13.5	TLR2, TLR4
30	alveolar echinococcosis	13.5	IL10, IFNG, TNF
31	ocular cicatricial pemphigoid	13.5	CIITA, IL4, TNF
32	leprosy	13.5	IL10, TLR1, TLR2, SLC11A1
33	folliculitis	13.5	IL4, IFNG, GNLY, DEFB4A
34	endotoxin hyporesponsiveness	13.5	TNF, TLR2, TLR4
35	plasmodium falciparum malaria	13.5	IL10, IL18, CCL4, IFNG
36	autoimmune thyroiditis	13.5	CIITA, IL12B, IL4, IFNG
37	neisseria meningitidis infection	13.5	MBL2, TLR2, TLR4
38	classic kaposi sarcoma	13.4	IL10, IL4, TNF
39	cerebral malaria	13.4	IL10, IL12B, IFNG, TNF
40	mycobacterium fortuitum	13.4	IL12RB1, HSPD1
41	genital herpes	13.4	IL4, CCL3, TLR2, DEFB4A
42	cicatricial pemphigoid	13.4	CIITA, IL4, IFNG, TNF
43	cysticercosis	13.4	IL10, IL18, IL4, TNF
44	poliomyelitis	13.4	IL10, IL4, IFNG, TNF
45	meningococcal infection	13.4	IL10, TNF, TLR4
46	spotted fever	13.4	IL10, IFNG, TNF
47	cramps	13.4	IL10, IL12B, IFNG, TNF
48	spondylocostal dysostosis	13.4	CD9, TLR4
49	coccidioidomycosis	13.3	IL10, MBL2, IFNG, IFNGR1, TLR4
50	guillain-barre syndrome	13.3	IL10, MBL2, IFNG, TNF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amikacin, amikacin sulfate, kanamycin, kanamycin sulfate, streptomycin, streptomycin sulfate

MalaCards organs/tissues related to mycobacterial infection:

²²

MGI Mouse Phenotypes related to mycobacterial infection:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	CFTR, IL12B
2	renal/urinary system phenotype	MP:0005367	9.5	IFNGR1, GATA2, CYBB, TRIM21
3	endocrine/exocrine gland phenotype	MP:0005379	8.8	IFNG, TLR2, GATA2, IL2
4	digestive/alimentary phenotype	MP:0005381	8.7	CCL3, SLC11A1, STAT1, TLR2, CYBB, IFNG
5	muscle phenotype	MP:0005369	8.3	STAT1, TLR2, SPP1, CYBB, TNF, IL6
6	integument phenotype	MP:0010771	8.3	IKBKG, IL4, P2RX7, IFNG, TRIM21, TLR2
7	skeleton phenotype	MP:0005390	8.3	P2RX7, STAT1, SPP1, CSF2, IL6, CD9
8	hematopoietic system phenotype	MP:0005397	8.2	GATA2, IFNGR2, P2RX7, CD247, IL12B, IL12RB1
9	liver/biliary system phenotype	MP:0005370	7.9	IKBKG, IFNG, IFNGR1, TLR2, IL6, TLR4
10	reproductive system phenotype	MP:0005389	7.2	IL4, IL15, IL10, SPP1, TNF, IFNG
11	homeostasis/metabolism phenotype	MP:0005376	6.7	GATA2, HAMP, TLR4, CSF2, STAT1, CCL3
12	tumorigenesis	MP:0002006	6.5	TLR4, STAT1, CSF2, SLC11A1, IL2, SPP1
13	mortality/aging	MP:0010768	5.7	CCL3, IL6, IL12B, CD247, CFTR, CYBB
14	growth/size phenotype	MP:0005378	5.6	CYBB, PIK3CG, GATA2, HAMP, CSF2, STAT1
15	behavior/neurological phenotype	MP:0005386	5.6	IFNG, CSF2, CFTR, P2RX7, IL18, IL10
16	cardiovascular system phenotype	MP:0005385	5.5	STAT1, CYBB, IL18, SPP1, CSF2, GATA2
17	immune system phenotype	MP:0005387	5.3	HAMP, CIITA, SLC11A1, CSF2, STAT1, TNF
18	cellular phenotype	MP:0005384	4.5	TLR2, TLR4, GATA2, STAT1, CFTR, P2RX7

Articles related to mycobacterial infection:

(show all 47)

id	Title	Authors	Year	Affiliating Genes
1	Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. (21670465)	Hsu A.P.... Holland S.M.	2011	GATA2
2	The human cathelicidin hCAP18/LL-37: a multifunctiona l peptide involved in mycobacterial infections. (20600427)	MAcndez-Samperio P.	2010	CAMP
3	Role of STAT1, NF-kappaB, and C/EBPbeta in the macrop hage transcriptional regulation of hepcidin by mycobacterial infection and IFN- gamma. (19652026)	Sow F.B.... Lafuse W.P.	2009	IL6, STAT1, IFNG
4	Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxy vitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infect ion. (20157607)	Lee J.S.... Jo E.K.	2009	IFNG
5	Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. (18453604)	Schaefer M.... Sparwasser T.	2008	IL10, CD209
6	Genetically determined susceptibility to mycobacterial infection. (18326015)	Patel S.Y.... Kumararatne D.S.	2008	IFNG
7	Role of C-type lectins in mycobacterial infections. (18288961)	Torrelles J.B.... Schlesinger L.S.	2008	CD209, CLEC12A, CLEC3A
8	The use of adjuvant granulocyte-macrophage colony-stimulating factor in HIV-related disseminated atypical mycobacterial infection. (17197031)	de Silva T.I.... Greig J.M.	2007	CSF2
9	Prospective analysis of cystic fibrosis transmembrane regulator mutations in adults with bronchiectasis or pulmonary nontuberculous mycobacterial infection. (17035430)	Ziedalski T.M.... Ruoss S.J.	2006	CFTR
10	Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection. (16412049)	Khajoee V.... Hara T.	2006	SPP1
11	Disseminated nontuberculous mycobacterial infection in a child with interferon-gamma receptor 1 deficiency. (16602008)	Tsolia M.N.... Spyridis P.	2006	IFNGR1
12	Human host genetic factors in nontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon-gamma-dependent signaling. (16520075)	Haverkamp M.H.... Holland S.M.	2006	IFNG
13	Anti-IFN-gamma autoantibodies in disseminated nontuberculous mycobacterial infections. (16177125)	Patel S.Y.... Holland S.M.	2005	IFNG
14	Susceptibility to mycobacterial infections due to interferon-gamma and interleukin-12 pathway defects. (16450579)	Tran D.Q.	2005	IFNG
15	Nontuberculous mycobacterial infection: CT scan findings, genotype, and treatment responsiveness. (16354855)	Kim J.S.... Lynch D.A.	2005	SERPINA1, CFTR
16	Improved diagnosis of mycobacterial infections in formalin-fixed and paraffin-embedded sections with nested polymerase chain reaction. (16218933)	Azov A.G.... Hamilton-Dutoit S.J.	2005	HSPD1
17	Normal expression of IFN-gammaR in four patients with uncommon mycobacterial infection phenotypes. (15334201)	Rugeles M.T.... Patino P.J.	2004	STAT1, IFNGR1, IFNG
18	Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity. (14679469)	DAPffinger R.... Kumararatne D.S.	2004	IFNG
19	Induction of apoptosis and release of interleukin-1 beta by cell wall-associated 19-kDa lipoprotein during the course of mycobacterial infection. (15319868)	Ciaramella A.... Fraziano M.	2004	TLR2
20	Adjunctive immunotherapy of mycobacterial infections. (15544517)	Tomioka H.	2004	TNF, IL2, IL18
21	THP-1 cell apoptosis in response to Mycobacterial infection. (12496173)	Riendeau C.J.... Kornfeld H.	2003	TNF
22	Susceptibility to mycobacterial infections: the importance of host genetics. (12595896)	Bellamy R.	2003	IFNG, IL12B, SLC11A1
23	Study on the roles of cytokines involved in mycobacterial infection. (12235851)	Sugawara I.	2002	TNF, IFNG
24	Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection. (11722641)	Seitzer U.... Maeurer M.J.	2001	IFNG, CD247
25	Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood. (11420412)	Remus N.... Casanova J.L.	2001	IFNGR1, IFNGR2
26	TNF-alpha-mediated multiplication of human immunodeficiency virus in chronically infected monocytoid cells by mycobacterial infection. (11552951)	Kitaura H.... Yamada T.	2001	TNF, CD9
27	Genetic heterogeneity of Mendelian susceptibility to mycobacterial infection. (11113374)	Doffinger R.... Casanova J.L.	2000	IFNGR2
28	Genetic predisposition to infective diseases in humans. Mendelian predisposition to mycobacterial infections (11261247)	Casanova J.L.	2000	IL12RB1, IFNGR2
29	Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection. (10880373)	Nau G.J.... Young R.A.	2000	SPP1
30	From gene to disease; mutations in interleukin-12-receptor-beta 1- and interferon-gamma-receptor-1 lead to nontuberculous mycobacterial infections and salmonellosis (11020837)	van Dissel J.T.... Ottenhoff T.H.	2000	IFNGR1, IL12RB1
31	Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. (10318940)	Tsenova L.... Kaplan G.	1999	TNF
32	Understanding the genetic basis of susceptibility to mycobacterial infection. (10417738)	Levin M.... Newport M.	1999	IFNG
33	A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. (10192386)	Jouanguy E.... Casanova J.L.	1999	IFNGR1
34	Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-gamma-receptor (IFNgammaR1) deficiency: mutational analysis and evaluation of therapeutic options. (10480427)	Roesler J.... Rosen-Wolff A.	1999	IFNGR1
35	Interleukin-15 in mycobacterial infection of antigen-presenting cells. (10447937)	Maeurer M.... Seitzer U.	1999	IL15
36	Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. (9616207)	Dorman S.E.... Holland S.M.	1998	IFNG, IFNGR2
37	Mendelian susceptibility to mycobacterial infection i n man. (9722917)	Altare F.... Casanova J.L.	1998	IL12B
38	Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study. (9355125)	Blackwell J.M.... Shaw M.A.	1997	SLC11A1
39	Intractable mycobacterial infections associated with genetic defects in the receptor for interferon gamma: what does this tell us about immunity to mycobacteria? (9381426)	Rook G.A.	1997	IFNG
40	Host defense against nontuberculous mycobacterial infections. (8976576)	Holland S.M.	1996	CSF2
41	A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. (8960473)	Newport M.J.... Levin M.	1996	TNF, IFNGR1, IFNG
42	Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred. (8592339)	Newport M.... Huxley C.	1995	SLC11A1
43	Cytokine patterns at the site of mycobacterial infection. (7713551)	Sieling P.A.... Modlin R.L.	1994	IL2
44	Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. A preliminary report. (7908719)	Holland S.M.... Gallin J.I.	1994	IFNG
45	Potential role of cytokines in disseminated mycobacterial infections. (7875149)	Bermudez L.E.	1994	IFNG
46	Analysis of host defense mechanism against mycobacterial infection and its application to therapy with biological response modifiers (7837726)	Kawakami K.	1994	IFNG
47	A study of autoantibodies in chronic mycobacterial infections. (2401838)	Rapoport B.L.... Dos Santos L.	1990	TRIM21

Genes related to mycobacterial infection according to GeneCards:

(show all 41)

id	Symbol	Description	Score	GeneCards Section Context
1	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	11.1	Summaries, Publications
2	IFNGR1	interferon gamma receptor 1	11.1	Publications, Summaries
3	STAT1	signal transducer and activator of transcription 1, 91kDa	11.0	Publications
4	GNLY	granulysin	11.0
5	IL12RB1	interleukin 12 receptor, beta 1	11.0	Publications
6	CD209	CD209 molecule	11.0	Publications
7	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
8	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications
9	TLR1	toll-like receptor 1	11.0
10	DEFB4A	defensin, beta 4A	11.0
11	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
12	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
13	IFNG	interferon, gamma	11.0	Publications
14	P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	11.0
15	CIITA	class II, major histocompatibility complex, transactivator	11.0
16	CCL4	chemokine (C-C motif) ligand 4	11.0
17	IL10	interleukin 10	11.0	Publications
18	TNF	tumor necrosis factor	11.0	Publications
19	IL4	interleukin 4	11.0
20	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0
21	TLR2	toll-like receptor 2	11.0	Publications
22	TLR4	toll-like receptor 4	11.0
23	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	11.0
24	CCL3	chemokine (C-C motif) ligand 3	11.0
25	CLEC3A	C-type lectin domain family 3, member A	11.0	Publications
26	GATA2	GATA binding protein 2	11.0	Publications
27	HAMP	hepcidin antimicrobial peptide	11.0	Publications
28	CLEC12A	C-type lectin domain family 12, member A	11.0	Publications
29	CAMP	cathelicidin antimicrobial peptide	11.0	Publications
30	CD247	CD247 molecule	11.0	Publications
31	TRIM21	tripartite motif containing 21	11.0	Publications
32	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	11.0
33	CYBB	cytochrome b-245, beta polypeptide	11.0
34	CD9	CD9 molecule	11.0	Publications
35	SPP1	secreted phosphoprotein 1	11.0	Publications
36	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
37	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
38	IL15	interleukin 15	11.0	Publications
39	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
40	IL2	interleukin 2	11.0	Publications
41	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to mycobacterial infection according to GeneDecks:

(show top 50)    (show all 108)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	9.7	CFTR, IKBKG, TLR1, TLR2, DEFB4A
2	Leishmaniasis20	9.5	IL10, IL12B, IL4, IFNG, IFNGR1, IFNGR2
3	Immune response_Bacterial infections in normal airways41	9.5	CFTR, IKBKG, IFNG, IFNGR1, IFNGR2, TLR1
4	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	TLR4, TLR1, IL12B, TLR2, IL6, IFNG
5	IL-6 Pathway36	9.3	CCL4, IL10, CSF2, CCL3, IL4, IL18
6	Immune System38	9.3	CSF2, DEFB4A, IFNG, IL18, P2RX7, CIITA
7	African trypanosomiasis20	9.3	IL6, IL12B, IFNG, TNF, IL10, IL18
8	Malaria20	9.2	IL10, IL18, IL6, TNF, IFNG, TLR4
9	Amoebiasis20	9.2	IL12B, IL6, TLR2, TLR4, CSF2
10	Colorectal Cancer Metastasis36	9.1	TLR2, TLR1, TNF, IL6, TLR4, STAT1
11	Toxoplasmosis20	9.0	IFNGR1, IKBKG, IL12B, IL10, CIITA, PIK3CG
12	Influenza A20	9.0	TNF, STAT1, TLR4, IFNGR2, IFNGR1, IFNG
13	Allograft rejection20	8.9	TNF, IFNG, IL4, IL2, IL12B, IL10
14	THC Differentiation Pathway36	8.9	IL12RB1, IL18, IL2, IL4, IFNG, IFNGR2
15	Osteoclast differentiation20	8.8	TNF, IFNGR2, IFNGR1, IFNG, CYBB, IKBKG
16	Endothelin-1 Signaling Pathway36	8.7	IL10, IL2, CCL3, IL6, IL4, IL18
17	PGC1Alpha Pathway36	8.7	IL18, IL2, CCL3, IL4, CCL4, IL15
18	Th1 Differentiation37	8.6	IL10, IL12B, IL12RB1, IL18, TLR4, TLR2
19	RAR-Gamma-RXR-Alpha Degradation36	8.5	CCL3, CSF2, CCL4, IL2, IL15
20	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.5	CCL3, CCL4, IL2, CSF2, IL15
21	Cytokine production by Th17 cells in CF41	8.5	IL6, CSF2, TLR4, IKBKG, IL12RB1, CFTR
22	Cytokine production by Th17 cells in CF (Mouse model)41	8.4	TLR4, CFTR, IKBKG, CSF2, IL12RB1, IL6
23	Tuberculosis20	8.3	TLR1, TLR2, TLR4, STAT1, IL6, IFNG
24	Toll-like receptor signaling pathway20	8.3	IKBKG, CCL3, CCL4, IL6, IL12B, PIK3CG
25	Cytokine Network36	8.2	TNF, IL10, IL12B, IL15, IL18, IL2
26	Rheumatoid arthritis20	8.2	TLR2, IL18, IFNG, IL6, TNF, TLR4
27	Measles20	8.2	CD209, IL2, IL4, IL6, IFNG, IFNGR1
28	Molecular Mechanisms of Cancer36	8.1	PIK3CG, IL2, IL12B, IL6, SPP1, IL15
29	ERK Signaling36	8.1	CCL3, IL6, STAT1, IL10, IL12B, IL18
30	NFAT Signaling and Lymphocyte Interactions36	8.0	IL15, IL4, CCL3, CCL4, IL6, IL2
31	T cell receptor signaling pathway20	8.0	PIK3CG, CD247, IL10, IL2, CSF2, IL4
32	SOCS Pathway36	7.9	STAT1, IL10, IL12B, IL18, IL2, CCL3
33	Regulation of eIF4 and p70S6K36	7.8	IL18, CCL3, CCL4, IL6, IL2, IL15
34	JAK-STAT Pathway36	7.6	STAT1, IL6, IFNGR2, IFNGR1, IFNG, CCL3
35	Glucocorticoid Receptor Signaling36	7.6	IL4, IL2, IL6, IL18, IL15, IL12B
36	Tec Kinases Signaling36	7.5	IL10, CCL3, TLR2, TLR4, STAT1, IL12RB1
37	Chagas disease (American trypanosomiasis)20	7.5	IL12B, IL10, CD247, PIK3CG, IL2, IL6
38	MAPK Family Pathway36	7.5	TNF, IL10, IL12RB1, IL15, IL18, IL6
39	all-trans-Retinoic Acid Signaling in Brain36	7.3	TNF, CCL3, CCL4, IL4, IL2, IL18
40	Jak-STAT signaling pathway20	7.2	CSF2, STAT1, IFNGR2, IFNGR1, IFNG, IL6
41	STAT3 Pathway36	7.2	IL4, TNF, CSF2, IL15, CCL3, CCL4
42	PAK Pathway36	7.2	IL4, IL10, IL6, IL12B, IL15, IL18
43	MIF Regulation of Innate Immune Cells36	7.2	CCL4, IL6, IL4, IL2, IL18, IL15
44	MIF Mediated Glucocorticoid Regulation36	7.2	IL4, IL2, IL18, IL15, IL12B, IL10
45	PEDF Induced Signaling36	7.0	IL2, IL4, IL18, IL15, IL12B, IL10
46	p38 Signaling36	7.0	STAT1, CSF2, IL10, IL4, IL12RB1, IL15
47	Cytokine-cytokine receptor interaction20	6.9	IL4, IL6, CCL4, CCL3, IFNG, IFNGR2
48	Akt Signaling36	6.7	CCL3, TNF, IKBKG, CCL4, IL4, IL2
49	Rho Family GTPases36	6.6	IL10, IL15, IL18, IL2, CCL4, IL6
50	Antioxidant Action of Vitamin-C36	6.6	IL12B, IL12RB1, IL15, IL18, IL2, IL4

Compounds related to mycobacterial infection according to GeneDecks:

(show top 50)    (show all 199)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	9.7	CIITA, IL12B, IL18, CCL4, CCL3, HSPD1
2	flagellin32	9.6	TLR1, TLR2, IL18, TLR4, HSPD1, DEFB4A
3	ionomycin32	9.4	CAMP, CSF2, GNLY, CCL3, CCL4, IL12RB1
4	sb 20358032 42	10.3	TNF, SPP1, STAT1, P2RX7, IL6, CCL4
5	toxin-132	9.0	CCL3, TNF, CCL4, IL2, IL10, CIITA
6	mdms32	9.0	CCL3, IL10, CIITA, CSF2, STAT1, CCL4
7	imiquimod32 42 9 9	11.8	IL10, IL12B, IL18, IL6, IFNG, TNF
8	mip 1alpha32	8.7	IL4, IL6, CCL4, CCL3, TNF, CSF2
9	pge232	8.7	CIITA, P2RX7, CFTR, CCL4, CCL3, CAMP
10	polymyxin b32	8.7	CAMP, TNF, TLR2, TLR4, HSPD1, IFNG
11	simvastatin32 34 42 9 18 9	13.6	IFNG, TLR4, TNF, CCL3, CCL4, IL6
12	lipoteichoic acid32	8.6	IL10, IL12B, IL18, IL6, MBL2, CCL3
13	ccl332	8.5	TNF, TLR2, TLR4, IFNG, CCL3, IL10
14	anti-fungal32	8.5	HAMP, CSF2, IL15, TLR4, TLR2, GNLY
15	calcitriol32 42 9 18 9	12.5	IL2, CAMP, SPP1, TLR2, STAT1, CSF2
16	infliximab32 9 9	10.4	IFNG, TLR4, IL6, IL10, IL15, IL18
17	vegf32	8.4	PIK3CG, MBL2, CCL4, CCL3, HSPD1, CAMP
18	mannose32	8.4	CD9, MBL2, CCL4, HSPD1, TLR2, TLR4
19	ribavirin32 34 9 9	11.2	STAT1, CSF2, IFNG, CCL3, MBL2, IL4
20	peptidoglycan32	8.2	DEFB4A, TLR4, CIITA, IL10, IL12B, IL15
21	poly(i-c)32	7.9	IL12B, IL15, IL18, IL4, IL6, CCL3
22	h2o232	7.8	CFTR, CYBB, IL18, STAT1, CSF2, CLEC12A
23	chloroquine32 34 9 9	10.8	CFTR, IL10, IL15, IL2, IL4, TNF
24	tacrolimus32 34 9 9	10.6	IFNG, TNF, SPP1, TLR4, TLR2, CCL4
25	cysteine32	7.6	CD9, CFTR, IL15, CCL4, CCL3, CSF2
26	polysaccharide32	7.6	TLR2, HSPD1, CSF2, CCL3, CCL4, CD209
27	okt332	7.6	IL10, IL2, IL4, IL6, IFNG, TNF
28	pd 98,05932	7.6	TLR2, DEFB4A, STAT1, CSF2, TNF, IL18
29	pentoxifylline32 9 9	9.5	CD9, IL10, IL12B, IL18, IL2, IL4
30	neopterin32	7.4	CD9, IL10, IL18, IL2, IL4, IL6
31	gm-csf32	7.4	CSF2, TNF, IL10, IL15, IL18, IL2
32	oxygen32 18	8.4	MBL2, CCL4, HSPD1, CIITA, IL18, HAMP
33	il-1232	7.4	IL10, IL12B, IL12RB1, IL15, IL18, IL2
34	polyinosinic-polycytidylic acid32	7.4	TNF, TLR2, TLR4, STAT1, CIITA, IL10
35	indomethacin32 9 9	9.1	IL4, IL6, CCL3, IL18, CFTR, IFNG
36	vitamin d32	7.1	MBL2, IL6, IL12B, IL10, CFTR, CAMP
37	cholesterol32 9 18 9	10.1	TLR4, STAT1, CIITA, TLR2, CD9, CAMP
38	il 1032	6.8	TLR4, CSF2, TLR2, TNF, IL10, IL12B
39	nitric oxide32 9 18 9	9.5	CCL3, SERPINA1, CIITA, CD9, IL10, IL12B
40	histamine32 18	7.5	IL10, TLR2, TLR4, DEFB4A, CSF2, TNF
41	actinomycin d32	6.4	PIK3CG, CIITA, CFTR, IL2, IL4, IL6
42	genistein32 9 18 9	9.3	STAT1, SPP1, TNF, CAMP, IFNG, IL6
43	thymidine32 18	7.1	IL6, CSF2, TNF, CAMP, CIITA, CCL3
44	rantes32	5.6	CIITA, CD209, CD9, IL10, IL12B, IL15
45	cycloheximide32	5.6	PIK3CG, TLR4, STAT1, CSF2, GATA2, TLR2
46	lipid32	5.5	PIK3CG, SERPINA1, CLEC12A, CIITA, P2RX7, CD209
47	retinoic acid32 42 18	7.4	TLR4, DEFB4A, STAT1, CSF2, GATA2, IL15
48	cyclosporin a32 42	6.4	TLR4, STAT1, CSF2, PIK3CG, CIITA, P2RX7
49	dexamethasone32 42 34 9 9	8.4	HSPD1, CAMP, TNF, CYBB, SPP1, TLR2
50	tyrosine32	3.7	IL2, IL4, IL6, MBL2, CCL4, IKBKG

Cellular components related to mycobacterial infection according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phagocytic vesicle membrane	GO:030670	9.9	CYBB, TLR1, SLC11A1
2	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:035354	9.9	TLR1, TLR2
3	external side of plasma membrane	GO:009897	9.1	TLR4, TNF, P2RX7, CD9, IL12RB1, IL4
4	integral to plasma membrane	GO:005887	8.1	TLR4, SLC11A1, TLR2, P2RX7, CD9, IL15
5	extracellular space	GO:005615	5.7	CCL4, CCL3, IFNG, IL10, HSPD1, TNF
6	extracellular region	GO:005576	5.5	MBL2, HAMP, IL6, IL2, IL18, IL15

Biological processes related to mycobacterial infection according to GeneDecks:

(show top 50)    (show all 81)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of interferon-gamma-mediated signaling pathway	GO:060334	10.4	STAT1, IFNGR2, IFNGR1, IFNG
2	positive regulation of T-helper 1 type immune response	GO:002827	10.4	SLC11A1, IL12B, IL12RB1
3	defense response to protozoan	GO:042832	10.4	IFNG, IL12B, SLC11A1
4	type 2 immune response	GO:042092	10.4	IL18, IL4, IL10
5	positive regulation of T cell mediated cytotoxicity	GO:001916	10.4	P2RX7, IL12RB1, IL12B
6	macrophage activation	GO:042116	10.3	TLR1, TLR4, SLC11A1
7	cellular response to interferon-gamma	GO:071346	10.3	IL12B, IL12RB1, IL18, CCL3
8	positive regulation of chemokine biosynthetic process	GO:045080	10.3	TNF, IL4, IFNG
9	negative regulation of interleukin-17 production	GO:032700	10.3	TLR2, TLR4, IFNG, IL12B
10	interferon-gamma-mediated signaling pathway	GO:060333	10.2	IFNG, STAT1, IFNGR1, CIITA, IFNGR2
11	T-helper 1 type immune response	GO:042088	10.2	TLR4, IL18, IL12B
12	positive regulation of interleukin-10 production	GO:032733	10.2	HSPD1, TLR4, IL4, IL12B
13	positive regulation of tumor necrosis factor biosynthetic process	GO:042535	10.2	TLR4, TLR1, TLR2
14	positive regulation of NF-kappaB import into nucleus	GO:042346	10.2	TLR2, TNF, IL12B, TLR4
15	positive regulation of osteoclast differentiation	GO:045672	10.2	IL12B, IFNG, TNF
16	positive regulation of interleukin-12 production	GO:032735	10.1	TLR4, IFNG, HSPD1, TLR2, IL12B
17	positive regulation of nitric oxide biosynthetic process	GO:045429	10.1	IFNG, TNF, TLR2, TLR4
18	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	CIITA, IL10, IL4, IFNG, TLR4
19	negative regulation of interleukin-6 production	GO:032715	10.1	IL10, TLR4, TNF
20	cellular response to lipopolysaccharide	GO:071222	10.1	TLR4, IFNG, IL12B, IL10
21	positive regulation of natural killer cell proliferation	GO:032819	10.0	IL15, IL12B, IL18
22	positive regulation of interleukin-8 production	GO:032757	10.0	IL18, TLR2, TLR4
23	positive regulation of tumor necrosis factor production	GO:032760	10.0	CCL3, IFNG, TLR2, IL18, IL12B, TLR4
24	lipopolysaccharide-mediated signaling pathway	GO:031663	10.0	STAT1, TNF, TLR4, TLR2, IL18, CCL3
25	negative regulation of osteoclast differentiation	GO:045671	9.9	CCL3, IL4, TLR4
26	positive regulation of interleukin-1 beta secretion	GO:050718	9.9	P2RX7, CCL3, IFNG
27	neutrophil chemotaxis	GO:030593	9.9	CCL3, IFNG, SPP1, PIK3CG
28	response to virus	GO:009615	9.8	IFNGR1, IFNG, IKBKG, IFNGR2, TNF, STAT1
29	negative regulation of growth of symbiont in host	GO:044130	9.8	IL12B, MBL2, TNF, TLR2, IFNG, IL10
30	positive regulation of chemokine production	GO:032722	9.7	IL18, TLR2, IL6, TNF, TLR4
31	defense response to Gram-negative bacterium	GO:050829	9.7	IL12B, SLC11A1, TLR4, IL6, CAMP
32	positive regulation of isotype switching to IgG isotypes	GO:048304	9.7	IL2, IL4, IFNG
33	positive regulation of phagocytosis	GO:050766	9.7	GATA2, SLC11A1, MBL2
34	cytokine-mediated signaling pathway	GO:019221	9.6	CIITA, IL12RB1, IL6, IFNG, IFNGR2, STAT1
35	positive regulation of interleukin-6 production	GO:032755	9.6	TLR4, P2RX7, IL6, HSPD1, TLR2, TNF
36	positive regulation of activated T cell proliferation	GO:042104	9.6	IL12B, IL12RB1, IL4, IL2, IL18
37	defense response to bacterium	GO:042742	9.5	SLC11A1, IFNG, GNLY, CAMP, TLR1, TLR4
38	defense response to Gram-positive bacterium	GO:050830	9.5	TNF, CAMP, MBL2, IL6, TLR2, P2RX7
39	positive regulation of T cell proliferation	GO:042102	9.4	IFNG, IL12B, IL15, IL4, IL6
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.3	IKBKG, IL6, TNF, TLR2, TLR4
41	positive regulation of tissue remodeling	GO:034105	9.3	IL18, IL12B, IL2, IL15
42	positive regulation of interleukin-17 production	GO:032740	9.3	IL12B, IL15, IL18, IL2
43	positive regulation of interferon-gamma production	GO:032729	9.2	TNF, SLC11A1, IL12B, IL12RB1, IL18, TLR4
44	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.1	IL2, CSF2, IL4, IL12B
45	innate immune response	GO:045087	9.0	MBL2, CD209, PIK3CG, TLR2, P2RX7, IKBKG
46	positive regulation of inflammatory response	GO:050729	8.8	IL12B, CCL3, TLR2, TLR4, IL18, IL2
47	cell-cell signaling	GO:007267	8.6	IL10, IL15, CCL3, IL18, IL2, CCL4
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	CIITA, IL2, TNF, IL4, IFNG, TLR2
49	inflammatory response	GO:006954	7.3	SPP1, CCL4, CCL3, IKBKG, TNF, CYBB
50	immune response	GO:006955	7.2	TLR2, CCL4, CSF2, CIITA, IL15, IL18

Molecular functions related to mycobacterial infection according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interferon-gamma receptor activity	GO:004906	10.3	IFNGR2, IFNGR1
2	lipopolysaccharide binding	GO:001530	9.9	HSPD1, TLR4, P2RX7
3	growth factor activity	GO:008083	8.1	CSF2, IL12B, IL2, IL4, IL6, IL10
4	cytokine activity	GO:005125	6.7	IL4, CSF2, SPP1, TNF, IFNG, CCL4
5	protein binding	GO:005515	4.7	SERPINA1, TNF, CYBB, TLR4, STAT1, CSF2