MCID: MYC013
MIFTS: 33

Mycobacterium Abscessus malady

Summaries for Mycobacterium Abscessus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

MalaCards: Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to cystic fibrosis and keratitis. An important gene associated with Mycobacterium Abscessus is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are EBV LMP1 signaling and Immune response MIF-mediated glucocorticoid regulation. The compounds muramyl dipeptide and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Mycobacterium Abscessus

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42NIH Rare Diseases
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Aliases & Descriptions:

mycobacterium abscessus 42
mycobacterium abscessus infection 42
m. abscessus 42


Related Diseases for Mycobacterium Abscessus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to mycobacterium abscessus

Clinical Features for Mycobacterium Abscessus

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Drugs & Therapeutics for Mycobacterium Abscessus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mycobacterium Abscessus

Drug clinical trials:

Search ClinicalTrials for Mycobacterium Abscessus

Search NIH Clinical Center for Mycobacterium Abscessus

Search CenterWatch for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

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Anatomical Context for Mycobacterium Abscessus

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32MalaCards
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MalaCards organs/tissues related to Mycobacterium Abscessus:

32
Lung

Animal Models for Mycobacterium Abscessus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mycobacterium Abscessus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.9CLEC7A
2MP:00053818.4CFTR, NLRP3, TLR2, TNF, CLEC7A
3MP:00053707.6SYK, CFTR, SQSTM1, TNF, TLR2, NLRP3
4MP:00053977.0NLRP3, TLR2, TNF, SQSTM1, SYK, IL8
5MP:00053876.8IL8, CFTR, CLEC7A, SYK, SQSTM1, TNF
6MP:00053766.7MSRA, CFTR, SQSTM1, NLRP3, TLR2, TNF
7MP:00107686.6TNF, MSRA, CFTR, CLEC7A, SYK, SQSTM1

Publications for Mycobacterium Abscessus

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Genetic Variations for Mycobacterium Abscessus

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Expression for genes affiliated with Mycobacterium Abscessus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for genes affiliated with Mycobacterium Abscessus

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37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 53Reactome, 52R&D Systems
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Compounds for genes affiliated with Mycobacterium Abscessus

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1muramyl dipeptide44 2811.0TLR2, IL8
2hbd2449.9IL8, TLR2
3dexamethasone44 49 28 1112.8CFTR, CLEC7A, TLR2
4anakinra44 1110.8TNF, NLRP3
5azithromycin44 1110.7IL8, CFTR
6cilomilast449.7IL8, TNF
7n-tosyl-l-phenylalanine chloromethyl ketone449.7TNF, IL8
8taurine chloramine449.6TNF, IL8
9hcec449.6TLR2, IL8
10ulinastatin449.6IL8, TNF
11toxin-1449.6IL8, TNF
12mip 1alpha449.5TNF, IL8
13monosodium urate449.5SYK, IL8
14imiquimod44 28 59 1112.5IL8, TNF, TLR2
15polymyxin b449.4TNF, IL8, TLR2
16go 697644 5910.4TLR2, TNF, IL8
17lipoteichoic acid449.4TNF, IL8, TLR2
18polyinosinic-polycytidylic acid449.4TNF, TLR2, IL8
19poly(i-c)449.4TLR2, TNF, IL8
20il 10449.4TNF, IL8, TLR2
21peptidoglycan44 2810.4TNF, TLR2, IL8
22ccl344 2810.4IL8, TLR2, TNF
23gold sodium thiomalate449.4IL8, TNF
24leukotriene b444 59 2411.4TLR2, IL8, TNF
25alpha lipoic acid449.4SERPINA1, TNF, MSRA
26sp 60012544 5910.4TLR2, IL8, TNF
27fmlp449.4SYK
28superoxide44 2410.3TNF, SYK
29simvastatin44 49 59 28 11 2414.2TNF, IL8, TLR2
30h2o2449.1MSRA, SYK, CFTR
31rantes449.1SYK, TNF, TLR2
32mg 13244 5910.1IL8, CFTR, TNF
33cytochalasin d44 5910.0CFTR, SYK, IL8
34groalpha448.9TNF, SYK, IL8
35actinomycin d448.9TNF, IL8, CFTR, TLR2
36cyclosporin a44 28 5910.9TNF, IL8, CFTR, TLR2
37zymosan448.9SYK, TLR2, TNF, CLEC7A
38egcg448.8IL8, TNF, SYK
39curcumin448.8CFTR, TNF, IL8
40fibrinogen448.7SERPINA1, TLR2, SYK, TNF
41herbimycin a44 599.6SYK, TNF, IL8
42sb 20358044 599.6TNF, TLR2, IL8, SYK
43histamine44 28 2410.6IL8, SYK, TLR2, TNF
44n acetylcysteine448.5CFTR, IL8, SYK, TNF
45genistein44 28 59 2 11 2413.4CFTR, TNF, SYK, IL8
46serine448.2SYK, IL8, TLR2, TNF, SQSTM1
47nitric oxide44 11 2410.2SYK, IL8, TLR2, TNF, SERPINA1
48cysteine447.9MSRA, TLR2, CFTR, IL8, SYK, SERPINA1
49lipid447.8TLR2, SYK, SERPINA1, MSRA, TNF
50oxygen44 248.3SQSTM1, TNF, SYK, IL8, MSRA, SERPINA1

GO Terms for genes affiliated with Mycobacterium Abscessus

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16Gene Ontology
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Cellular components related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2CLEC7A, TNF, TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:00275210.1TLR2, CLEC7A
2negative regulation of growth of symbiont in hostGO:0441309.8TLR2, TNF
3positive regulation of tumor necrosis factor productionGO:0327609.8TLR2, CLEC7A
4positive regulation of chemokine productionGO:0327229.7TNF, TLR2
5regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7TNF, SQSTM1
6positive regulation of NF-kappaB import into nucleusGO:0423469.7TNF, TLR2
7cellular response to molecule of fungal originGO:0712269.6SYK, CLEC7A
8leukocyte activation involved in immune responseGO:0023669.6CLEC7A, SYK
9lipopolysaccharide-mediated signaling pathwayGO:0316639.6TNF, TLR2
10positive regulation of nitric oxide biosynthetic processGO:0454299.5TNF, TLR2
11defense response to Gram-positive bacteriumGO:0508309.5TNF, TLR2
12embryonic digestive tract developmentGO:0485669.5IL8, TNF
13positive regulation of NF-kappaB transcription factor activityGO:0510929.4TNF, TLR2, NLRP3
14positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.2TNF, NLRP3
15positive regulation of cytokine secretionGO:0507159.0TLR2, TNF, SYK
16innate immune responseGO:0450878.8NLRP3, TLR2, SYK, CLEC7A
17inflammatory responseGO:0069548.7IL8, CLEC7A, TNF, TLR2, NLRP3

Molecular functions related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signaling pattern recognition receptor activityGO:0083299.8CLEC7A, TLR2
2peptidoglycan bindingGO:0428349.5TLR2, NLRP3
3protein bindingGO:0055156.6TLR2, TNF, SQSTM1, SYK, IL8, CFTR

Products for genes affiliated with Mycobacterium Abscessus

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  • Antibodies
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Sources for Mycobacterium Abscessus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet