MCID: MYC013
MIFTS: 43

Mycobacterium Abscessus malady

Rare diseases category

Summaries for Mycobacterium Abscessus

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Wikipedia:63 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

MalaCards based summary: Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to cystic fibrosis and mastitis. An important gene associated with Mycobacterium Abscessus is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are IL-17 Family Signaling Pathways and Selected targets of GCR alpha. The compounds muramyl dipeptide and anakinra have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and breast, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Mycobacterium Abscessus

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Mycobacterium Abscessus, Aliases & Descriptions:

Name: Mycobacterium Abscessus 41
Mycobacterium Abscessus Infection 41
 
M. Abscessus 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Mycobacterium Abscessus

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Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis31.3IL8, SERPINA1, CFTR
2mastitis30.9IL8, TLR2
3peritonitis30.9TLR2, TNF
4arthritis30.6IL8, SERPINA1, TNF
5liver cirrhosis30.5TLR2, SERPINA1, SQSTM1
6tuberculosis30.5TLR2, TNF, SERPINA1, CLEC7A
7meningitis30.5IL8, TLR2
8respiratory failure30.3CFTR, TNF, SERPINA1
9pneumonia30.3IL8, SERPINA1, TNF, CFTR, TLR2
10rheumatoid arthritis29.6TLR2, CFTR, TNF, SERPINA1, IL8, SYK
11mycobacterium chelonae10.9
12mycobacterium fortuitum10.6
13keratitis10.5
14endocarditis10.5
15endophthalmitis10.5
16otitis media10.5
17aspergillosis10.5TLR2
18muckle-wells syndrome10.5NLRP3
19osteomyelitis10.5
20mammary paget's disease10.5SQSTM1
21leprosy10.5TLR2
22bronchitis10.4SERPINA1
23emphysema due to aat deficiency10.4SERPINA1
24pick disease10.4SQSTM1
25bacteremia10.4
26intestinal obstruction10.4CFTR
27sinusitis10.4CFTR
28keratopathy10.3
29lymphadenitis10.3
30blau syndrome10.3NLRP3, TNF
31familial mediterranean fever, ar10.2NLRP3, TNF
32psoriatic arthritis10.2TLR2, TNF
33bacterial meningitis10.2IL8, TLR2
34periodontitis10.2TLR2, IL8
35viral hepatitis10.2TLR2, SERPINA1
36viral meningitis10.2IL8, SERPINA1
37cataract10.2
38pulmonary tuberculosis10.2
39transsexualism10.2
40pharyngitis10.2
41septic arthritis10.2
42epidural abscess10.2
43cellulitis10.2
44cervicitis10.2
45conjunctivitis10.2
46corneal ulcer10.2
47dermatitis10.2
48hypopyon10.2
49mediastinitis10.2
50prostatitis10.2

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to mycobacterium abscessus

Symptoms for Mycobacterium Abscessus

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Drugs & Therapeutics for Mycobacterium Abscessus

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Drug clinical trials:

Search ClinicalTrials for Mycobacterium Abscessus

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

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Anatomical Context for Mycobacterium Abscessus

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MalaCards organs/tissues related to Mycobacterium Abscessus:

31
Lung, Testes, Breast, Skin, Colon, T cells, Cortex, Heart, Adrenal cortex, Eye, Kidney, Liver, Prostate, Endothelial, Neutrophil

Animal Models for Mycobacterium Abscessus or affiliated genes

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MGI Mouse Phenotypes related to Mycobacterium Abscessus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3TLR2, CFTR, TNF, CLEC7A, NLRP3
2MP:00053888.0TLR2, CFTR, TNF, CLEC7A, SYK
3MP:00053787.8NLRP3, SQSTM1, MSRA, TNF, CFTR, TLR2
4MP:00053707.7TLR2, CFTR, TNF, SYK, SQSTM1, NLRP3
5MP:00053907.7TLR2, TNF, SYK, SQSTM1, NLRP3
6MP:00053847.1TLR2, CFTR, TNF, MSRA, SYK, SQSTM1
7MP:00053976.9NLRP3, TLR2, CFTR, TNF, CLEC7A, IL8
8MP:00053876.9TLR2, CFTR, TNF, CLEC7A, IL8, SYK
9MP:00053766.9TLR2, CFTR, TNF, CLEC7A, MSRA, SYK
10MP:00107686.8TLR2, CFTR, TNF, CLEC7A, MSRA, SYK

Publications for Mycobacterium Abscessus

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Articles related to Mycobacterium Abscessus:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells. (25638774)
2015
2
Rapid detection and immune characterization of Mycobacterium abscessus infection in cystic fibrosis patients. (25742660)
2015
3
Utility of Sequencing the erm(41) Gene in Isolates of Mycobacterium abscessus subsp. abscessus with Low and Intermediate Clarithromycin MICs. (25653399)
2015
4
Essential Engagement of Toll-Like Receptor 2 in Initiation of Early Protective Th1 Response against Rough Variants of Mycobacterium abscessus. (25644006)
2015
5
Risk Factors for Mycobacterium abscessus subsp. bolletii infection after laparoscopic surgery during an outbreak in Brazil. (25627765)
2015
6
Bacterial phospholipases C as vaccine candidate antigens against cystic fibrosis respiratory pathogens: The Mycobacterium abscessus model. (25804706)
2015
7
Management of Mycobacterium abscessus Post Abdominoplasty. (25338711)
2014
8
Classification algorithm for subspecies identification within the Mycobacterium abscessus species, based on matrix-assisted laser desorption ionization-time of flight mass spectrometry. (25009048)
2014
9
Inhaled therapies, azithromycin and Mycobacterium abscessus in cystic fibrosis patients. (22936714)
2013
10
Endovascular Mycobacterium abscessus infection in a heart transplant recipient: a case report and review of the literature. (23176090)
2013
11
Whole-Genome Shotgun Sequencing of Mycobacterium abscessus M156, an Emerging Clinical Pathogen in Malaysia. (23405341)
2013
12
Adherence and biofilm formation of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium abscessus to household plumbing materials. (23742161)
2013
13
Probable disseminated Mycobacterium abscessus subspecies bolletii infection in a patient with idiopathic CD4+ T lymphocytopenia: a case report. (22947084)
2012
14
Molecular typing of Mycobacterium abscessus based on tandem-repeat polymorphism. (22760048)
2012
15
Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic fibrosis center. (22246710)
2012
16
Mycobacterium abscessus pneumonia in an Atlantic bottlenose dolphin (Tursiops truncatus). (23272373)
2012
17
Strategies to improve outcome of drug treatment for Mycobacterium abscessus pulmonary disease. (21364074)
2011
18
Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. (21292659)
2011
19
Diversity of pulsed-field gel electrophoresis patterns of Mycobacterium abscessus type 2 clinical isolates. (21084521)
2011
20
Diagnosis of pulmonary disease caused by Mycobacterium abscessus: a case report. (21819731)
2011
21
Disseminated Mycobacterium abscessus infection and showerheads, Taiwan. (22099106)
2011
22
Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response. (21292749)
2011
23
Mycobacterium abscessus: a new player in the mycobacterial field. (20060723)
2010
24
Mycobacterium abscessus infection in transplant recipients. (20970610)
2010
25
Fatal Mycobacterium abscessus endocarditis misidentified as Corynebacterium spp. (19958237)
2010
26
An oxidative environment promotes growth of Mycobacterium abscessus. (20807564)
2010
27
Successful treatment of a prosthetic joint infection due to Mycobacterium abscessus. (20808461)
2009
28
Community-acquired mastitis due to Mycobacterium abscessus: a case report. (20062768)
2009
29
Unresolving furunculosis in a diabetic patient: cutaneous Mycobacterium abscessus infection. (19271048)
2009
30
Mycobacterium abscessus endocarditis: a case report and literature review. (19073380)
2008
31
Disseminated cutaneous infection with Mycobacterium abscessus in a patient with a low CD4+ T cell count. (18474467)
2008
32
Paradoxical worsening of pulmonary Mycobacterium abscessus. (17293101)
2007
33
Hypervirulence of a rough variant of the Mycobacterium abscessus type strain. (17145951)
2007
34
Use of PCR-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by Mycobacterium abscessus and Mycobacterium chelonae. (16414212)
2006
35
Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolates. (16529900)
2006
36
Multiple subcutaneous nodules associate with Mycobacterium abscessus infection following removal of an infected Groshon vascular catheter tip. (17083867)
2006
37
Disseminated mycobacterium abscessus infection in a hemodialysis patient with acquired reactive perforating collagenosis--a case study and literature review. (15678699)
2005
38
In vitro activity of fluoroquinolones against Mycobacterium abscessus and Mycobacterium chelonae causing infectious keratitis after LASIK in Brazil. (16015094)
2005
39
Infection with mycobacterium abscessus after Mohs micrographic surgery in an immunocompetent patient. (16029710)
2005
40
Cutaneous Mycobacterium abscessus infection after kidney transplantation. (15755761)
2005
41
Pneumonia due to Mycobacterium abscessus in two domestic ferrets (Mustelo putorius furo). (16164141)
2005
42
Mycobacterium abscessus as a cause of pacemaker infection. (15448601)
2004
43
Therapeutic keratectomy for Mycobacterium abscessus keratitis after LASIK. (14724729)
2003
44
Disseminated Mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis: case report and literature review. (11173189)
2001
45
DNA polymorphism of Mycobacterium abscessus analyzed by infrequent-restriction-site polymerase chain reaction. (11039248)
2000
46
Mycobacterium abscessus peritonitis: a case report. (10182108)
1998
47
A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae. (9607835)
1998
48
Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. (8807061)
1996
49
Differentiation between Mycobacterium abscessus and Mycobacterium borstelense. (4244292)
1970
50
Comparison of the pathogenicity for mice of Mycobacterium fortuitum and Mycobacterium abscessus. (5370281)
1969

Variations for Mycobacterium Abscessus

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Expression for genes affiliated with Mycobacterium Abscessus

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Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for genes affiliated with Mycobacterium Abscessus

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Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CFTR, TLR2
29.5TNF, TLR2
3
Show member pathways
IL27-mediated signaling events36
9.5TLR2, TNF
4
Show member pathways
9.5IL8, CFTR
5
Show member pathways
9.5IL8, CFTR
69.5TNF, SQSTM1
7
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.5TNF, SQSTM1
89.3IL8, TNF
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.3TNF, IL8
109.3TNF, IL8
119.3IL8, TNF
129.2CLEC7A, TNF, TLR2
13
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0IL8, TNF, TLR2
149.0IL8, TNF, TLR2
159.0TLR2, TNF, IL8
169.0TLR2, TNF, IL8
179.0TLR2, TNF, IL8
189.0TNF, IL8, NLRP3
19
Show member pathways
9.0TNF, IL8, NLRP3
20
Show member pathways
8.7SYK, TNF, TLR2
21
Show member pathways
8.7NLRP3, IL8, TNF, TLR2
228.7SQSTM1, SYK, TNF
23
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.6TLR2, CFTR, TNF, IL8
248.5TNF, IL8, SYK
258.4TLR2, TNF, CLEC7A, SYK
26
Show member pathways
8.2TLR2, TNF, IL8, SYK
27
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
7.1NLRP3, SYK, IL8, CLEC7A, TNF, CFTR

Compounds for genes affiliated with Mycobacterium Abscessus

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Compounds related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1muramyl dipeptide43 2811.0TLR2, IL8
2anakinra43 1210.8TNF, NLRP3
3hbd2439.7TLR2, IL8
4cilomilast439.7TNF, IL8
5n-tosyl-l-phenylalanine chloromethyl ketone439.6TNF, IL8
6taurine chloramine439.6IL8, TNF
7gabexate mesilate439.6IL8, TNF
8ulinastatin439.5TNF, IL8
9monosodium urate439.5IL8, SYK
10imiquimod43 59 28 1212.4TLR2, TNF, IL8
11polymyxin b439.4TLR2, TNF, IL8
12go 697643 5910.4TLR2, TNF, IL8
13lipoteichoic acid439.4IL8, TNF, TLR2
14polyinosinic-polycytidylic acid439.4TLR2, TNF, IL8
15poly(i-c)439.4TLR2, TNF, IL8
16il 10439.4IL8, TNF, TLR2
17peptidoglycan43 2810.4IL8, TNF, TLR2
18ccl343 2810.4TLR2, TNF, IL8
19azithromycin43 1210.4CFTR, IL8
20toxin-1439.4TNF, IL8
21leukotriene b443 59 2411.4IL8, TNF, TLR2
22sp 60012543 5910.4IL8, TNF, TLR2
23alpha lipoic acid439.3MSRA, SERPINA1, TNF
24mip 1alpha439.3TNF, IL8
25simvastatin43 49 59 28 24 1214.2TLR2, TNF, IL8
26mg 13243 5910.1CFTR, TNF, IL8
27cytochalasin d43 5910.0SYK, IL8, CFTR
28groalpha438.9SYK, IL8, TNF
29actinomycin d438.9IL8, TNF, CFTR, TLR2
30cyclosporin a43 28 5910.9TLR2, CFTR, TNF, IL8
31pge2438.9TLR2, CFTR, TNF, IL8
32curcumin438.9IL8, TNF, CFTR
33zymosan438.9TLR2, TNF, CLEC7A, SYK
34egcg438.8TNF, IL8, SYK
35endotoxin438.7IL8, TNF, TLR2
36fibrinogen438.7TLR2, TNF, SERPINA1, SYK
37herbimycin a43 599.7TNF, IL8, SYK
38rantes438.6SYK, IL8, TNF, TLR2
39sb 20358043 599.6TLR2, TNF, IL8, SYK
40histamine43 28 2410.6TLR2, TNF, IL8, SYK
41superoxide43 249.5TLR2, TNF, IL8, SYK
42n acetylcysteine438.5CFTR, TNF, IL8, SYK
43genistein43 28 59 2 24 1213.4CFTR, TNF, IL8, SYK
44nitric oxide43 24 1210.2SYK, IL8, SERPINA1, TNF, TLR2
45lipid438.0TLR2, TNF, SERPINA1, MSRA, SYK
46dexamethasone43 49 28 1210.9TLR2, CFTR, TNF, CLEC7A, IL8, SYK
47cysteine437.9TLR2, CFTR, SERPINA1, MSRA, IL8, SYK
48serine437.4TLR2, CFTR, TNF, SERPINA1, IL8, SYK
49oxygen43 248.3TLR2, TNF, SERPINA1, MSRA, IL8, SYK
50h2o2437.3SYK, IL8, MSRA, SERPINA1, TNF, CFTR

GO Terms for genes affiliated with Mycobacterium Abscessus

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Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.1TNF, CFTR, TLR2
2external side of plasma membraneGO:00098978.9CLEC7A, TNF, TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:000275210.2CLEC7A, TLR2
2positive regulation of tumor necrosis factor productionGO:003276010.0TLR2, CLEC7A
3positive regulation of interleukin-18 productionGO:00327419.9TLR2, TNF
4positive regulation of chemokine productionGO:00327229.8TNF, TLR2
5negative regulation of growth of symbiont in hostGO:00441309.8TNF, TLR2
6regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.8SQSTM1, TNF
7positive regulation of NF-kappaB import into nucleusGO:00423469.8TNF, TLR2
8lipopolysaccharide-mediated signaling pathwayGO:00316639.8TLR2, TNF
9positive regulation of nitric oxide biosynthetic processGO:00454299.7TNF, TLR2
10defense response to Gram-positive bacteriumGO:00508309.7TNF, TLR2
11cellular response to molecule of fungal originGO:00712269.7SYK, CLEC7A
12leukocyte activation involved in immune responseGO:00023669.7CLEC7A, SYK
13positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00432809.6NLRP3, TNF
14embryonic digestive tract developmentGO:00485669.6TNF, IL8
15positive regulation of interleukin-6 productionGO:00327559.5TNF, TLR2
16positive regulation of NF-kappaB transcription factor activityGO:00510929.5NLRP3, TNF, TLR2
17response to hypoxiaGO:00016669.4TLR2, TNF, SERPINA1
18response to cytokineGO:00340979.3SERPINA1, CFTR
19calcium-mediated signalingGO:00197229.2TNF, IL8
20neutrophil chemotaxisGO:00305939.2SYK, IL8
21positive regulation of cytokine secretionGO:00507159.1TLR2, TNF, SYK
22negative regulation of cell proliferationGO:00082859.0IL8, TNF, TLR2
23innate immune responseGO:00450878.9NLRP3, SYK, CLEC7A, TLR2
24inflammatory responseGO:00069548.7NLRP3, IL8, CLEC7A, TNF, TLR2

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1signaling pattern recognition receptor activityGO:00083299.9CLEC7A, TLR2
2peptidoglycan bindingGO:00428349.7NLRP3, TLR2
3protease bindingGO:00020209.4SERPINA1, TNF
4protein bindingGO:00055156.3TLR2, CFTR, TNF, SERPINA1, IL8, SYK

Products for genes affiliated with Mycobacterium Abscessus

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Sources for Mycobacterium Abscessus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet