MCID: MYC013
MIFTS: 50

Mycobacterium Abscessus malady

Rare diseases category
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Summaries for Mycobacterium Abscessus

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Wikipedia:65 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

MalaCards based summary: Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to cystic fibrosis and mastitis. An important gene associated with Mycobacterium Abscessus is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are IL-17 Family Signaling Pathways and Selected targets of GCR alpha. The compounds muramyl dipeptide and anakinra have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Mycobacterium Abscessus

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Mycobacterium Abscessus, Aliases & Descriptions:

Name: Mycobacterium Abscessus 42
Mycobacterium Abscessus Infection 42
 
M. Abscessus 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Mycobacterium Abscessus

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Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis31.2SERPINA1, IL8, CFTR
2mastitis30.9IL8, TLR2
3peritonitis30.8TLR2, TNF
4arthritis30.6IL8, SERPINA1, TNF
5liver cirrhosis30.5SQSTM1, SERPINA1, TLR2
6meningitis30.5TLR2, IL8
7respiratory failure30.3SERPINA1, TNF, CFTR
8tuberculosis30.2SERPINA1, TLR2, CLEC7A, TNF
9pneumonia30.2TLR2, CFTR, TNF, SERPINA1, IL8
10sepsis30.2TNF, TLR2, IL8
11rheumatoid arthritis29.6SERPINA1, SYK, TLR2, CFTR, TNF, IL8
12mycobacterium chelonae10.9
13mycobacterium fortuitum10.6
14aspergillosis10.5TLR2
15endophthalmitis10.5
16keratitis10.5
17otitis media10.5
18muckle-wells syndrome10.5NLRP3
19mammary paget's disease10.5SQSTM1
20leprosy10.5TLR2
21bronchitis10.4SERPINA1
22emphysema due to aat deficiency10.4SERPINA1
23pick's disease10.4SQSTM1
24endocarditis10.4
25osteomyelitis10.4
26bacteremia10.4
27intestinal obstruction10.4CFTR
28sinusitis10.4CFTR
29keratopathy10.3
30lymphadenitis10.3
31blau syndrome10.3TNF, NLRP3
32familial mediterranean fever10.3NLRP3, TNF
33psoriatic arthritis10.2TLR2, TNF
34bacterial meningitis10.2IL8, TLR2
35viral hepatitis10.2SERPINA1, TLR2
36periodontitis10.2IL8, TLR2
37viral meningitis10.2IL8, SERPINA1
38ankylosing spondylitis10.2SERPINA1, TNF
39cataract10.2
40kartagener syndrome10.2
41stevens-johnson syndrome10.2
42pulmonary tuberculosis10.2
43septic arthritis10.2
44transsexualism10.2
45epidural abscess10.2
46cellulitis10.2
47cervicitis10.2
48conjunctivitis10.2
49corneal ulcer10.2
50dermatitis10.2

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to mycobacterium abscessus

Symptoms for Mycobacterium Abscessus

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Drugs & Therapeutics for Mycobacterium Abscessus

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Drug clinical trials:

Search ClinicalTrials for Mycobacterium Abscessus

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

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Anatomical Context for Mycobacterium Abscessus

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MalaCards organs/tissues related to Mycobacterium Abscessus:

32
Lung, Testes, Skin, Colon, Breast, T cells, Cortex, Adrenal cortex, Eye, Heart, Kidney, Liver, Prostate, Endothelial

Animal Models for Mycobacterium Abscessus or affiliated genes

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MGI Mouse Phenotypes related to Mycobacterium Abscessus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3CLEC7A, CFTR, TNF, NLRP3, TLR2
2MP:00053888.0TNF, TLR2, SYK, CLEC7A, CFTR
3MP:00053787.8NLRP3, MSRA, TNF, CFTR, TLR2, SQSTM1
4MP:00053707.7NLRP3, SYK, TNF, CFTR, TLR2, SQSTM1
5MP:00053907.7TLR2, TNF, SYK, NLRP3, SQSTM1
6MP:00053847.1MSRA, TNF, CFTR, TLR2, SYK, SQSTM1
7MP:00053976.9SYK, CFTR, CLEC7A, IL8, SQSTM1, NLRP3
8MP:00053876.9CFTR, CLEC7A, NLRP3, IL8, SYK, SQSTM1
9MP:00053766.9CFTR, TNF, CLEC7A, MSRA, SYK, SQSTM1
10MP:00107686.8TLR2, CFTR, TNF, CLEC7A, SYK, SQSTM1

Publications for Mycobacterium Abscessus

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Articles related to Mycobacterium Abscessus:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Management of Mycobacterium abscessus Post Abdominoplasty. (25338711)
2014
2
Classification algorithm for subspecies identification within the Mycobacterium abscessus species, based on matrix-assisted laser desorption ionization-time of flight mass spectrometry. (25009048)
2014
3
Inhaled therapies, azithromycin and Mycobacterium abscessus in cystic fibrosis patients. (22936714)
2013
4
Endovascular Mycobacterium abscessus infection in a heart transplant recipient: a case report and review of the literature. (23176090)
2013
5
Whole-Genome Shotgun Sequencing of Mycobacterium abscessus M156, an Emerging Clinical Pathogen in Malaysia. (23405341)
2013
6
Adherence and biofilm formation of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium abscessus to household plumbing materials. (23742161)
2013
7
Multilocus sequence typing scheme for the Mycobacterium abscessus complex. (24384536)
2013
8
Comparative drug resistance of Mycobacterium abscessus and M. chelonae isolates from patients with and without cystic fibrosis in the United Kingdom. (23135941)
2013
9
Probable disseminated Mycobacterium abscessus subspecies bolletii infection in a patient with idiopathic CD4+ T lymphocytopenia: a case report. (22947084)
2012
10
Molecular typing of Mycobacterium abscessus based on tandem-repeat polymorphism. (22760048)
2012
11
Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic fibrosis center. (22246710)
2012
12
Mycobacterium abscessus pneumonia in an Atlantic bottlenose dolphin (Tursiops truncatus). (23272373)
2012
13
Strategies to improve outcome of drug treatment for Mycobacterium abscessus pulmonary disease. (21364074)
2011
14
Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. (21292659)
2011
15
Diversity of pulsed-field gel electrophoresis patterns of Mycobacterium abscessus type 2 clinical isolates. (21084521)
2011
16
Diagnosis of pulmonary disease caused by Mycobacterium abscessus: a case report. (21819731)
2011
17
Disseminated Mycobacterium abscessus infection and showerheads, Taiwan. (22099106)
2011
18
Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response. (21292749)
2011
19
Proposal that Mycobacterium massiliense and Mycobacterium bolletii be united and reclassified as Mycobacterium abscessus subsp. bolletii comb. nov., designation of Mycobacterium abscessus subsp. abscessus subsp. nov. and emended description of Mycobacterium abscessus. (21037035)
2011
20
Mycobacterium abscessus: a new player in the mycobacterial field. (20060723)
2010
21
Mycobacterium abscessus infection in transplant recipients. (20970610)
2010
22
Fatal Mycobacterium abscessus endocarditis misidentified as Corynebacterium spp. (19958237)
2010
23
An oxidative environment promotes growth of Mycobacterium abscessus. (20807564)
2010
24
Genetic manipulation of Mycobacterium abscessus. (20812214)
2010
25
Successful treatment of a prosthetic joint infection due to Mycobacterium abscessus. (20808461)
2009
26
Community-acquired mastitis due to Mycobacterium abscessus: a case report. (20062768)
2009
27
Unresolving furunculosis in a diabetic patient: cutaneous Mycobacterium abscessus infection. (19271048)
2009
28
Mycobacterium abscessus from respiratory isolates: activities of drug combinations. (19280301)
2009
29
Mycobacterium abscessus endocarditis: a case report and literature review. (19073380)
2008
30
Disseminated cutaneous infection with Mycobacterium abscessus in a patient with a low CD4+ T cell count. (18474467)
2008
31
Mycobacterium abscessus, an uncommon cause of chronic otitis media: a case report and literature review. (18794448)
2008
32
Paradoxical worsening of pulmonary Mycobacterium abscessus. (17293101)
2007
33
Hypervirulence of a rough variant of the Mycobacterium abscessus type strain. (17145951)
2007
34
Use of PCR-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by Mycobacterium abscessus and Mycobacterium chelonae. (16414212)
2006
35
Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolates. (16529900)
2006
36
Multiple subcutaneous nodules associate with Mycobacterium abscessus infection following removal of an infected Groshon vascular catheter tip. (17083867)
2006
37
Disseminated mycobacterium abscessus infection in a hemodialysis patient with acquired reactive perforating collagenosis--a case study and literature review. (15678699)
2005
38
In vitro activity of fluoroquinolones against Mycobacterium abscessus and Mycobacterium chelonae causing infectious keratitis after LASIK in Brazil. (16015094)
2005
39
Infection with mycobacterium abscessus after Mohs micrographic surgery in an immunocompetent patient. (16029710)
2005
40
Cutaneous Mycobacterium abscessus infection after kidney transplantation. (15755761)
2005
41
Pneumonia due to Mycobacterium abscessus in two domestic ferrets (Mustelo putorius furo). (16164141)
2005
42
Mycobacterium abscessus as a cause of pacemaker infection. (15448601)
2004
43
Therapeutic keratectomy for Mycobacterium abscessus keratitis after LASIK. (14724729)
2003
44
Disseminated Mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis: case report and literature review. (11173189)
2001
45
DNA polymorphism of Mycobacterium abscessus analyzed by infrequent-restriction-site polymerase chain reaction. (11039248)
2000
46
Mycobacterium abscessus peritonitis: a case report. (10182108)
1998
47
A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae. (9607835)
1998
48
Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. (8807061)
1996
49
Differentiation between Mycobacterium abscessus and Mycobacterium borstelense. (4244292)
1970
50
Comparison of the pathogenicity for mice of Mycobacterium fortuitum and Mycobacterium abscessus. (5370281)
1969

Variations for Mycobacterium Abscessus

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Expression for genes affiliated with Mycobacterium Abscessus

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Expression patterns in normal tissues for genes affiliated with Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for genes affiliated with Mycobacterium Abscessus

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Pathways related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TLR2, CFTR
29.6TLR2, IL8
39.6SERPINA1, CFTR
49.5TLR2, TNF
5
Show member pathways
IL27-mediated signaling events37
9.5TNF, TLR2
6
Show member pathways
9.5CFTR, IL8
7
Show member pathways
9.5CFTR, IL8
89.5TNF, SQSTM1
9
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.5SQSTM1, TNF
109.3TNF, IL8
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.3IL8, TNF
129.3IL8, TNF
139.3IL8, TNF
149.2TLR2, TNF, CLEC7A
159.0IL8, TNF, TLR2
16
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.0TLR2, IL8, TNF
179.0IL8, TNF, TLR2
189.0TLR2, TNF, IL8
199.0TLR2, TNF, IL8
20
Show member pathways
9.0NLRP3, IL8, TNF
219.0IL8, TNF, NLRP3
22
Show member pathways
8.7TLR2, SYK, TNF
23
Show member pathways
8.7IL8, TNF, TLR2, NLRP3
248.7SYK, SQSTM1, TNF
25
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.6CFTR, TLR2, IL8, TNF
268.5SYK, TNF, IL8
278.4TNF, SYK, CLEC7A, TLR2
28
Show member pathways
8.2TNF, IL8, SYK, TLR2
29
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.1TNF, SYK, IL8, CLEC7A, CFTR, TLR2

Compounds for genes affiliated with Mycobacterium Abscessus

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Compounds related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1muramyl dipeptide44 2811.0TLR2, IL8
2anakinra44 1110.8NLRP3, TNF
3hbd2449.7TLR2, IL8
4cilomilast449.7IL8, TNF
5n-tosyl-l-phenylalanine chloromethyl ketone449.6TNF, IL8
6taurine chloramine449.6TNF, IL8
7gabexate mesilate449.6IL8, TNF
8ulinastatin449.5IL8, TNF
9monosodium urate449.5SYK, IL8
10imiquimod44 61 28 1112.5IL8, TLR2, TNF
11polymyxin b449.4IL8, TNF, TLR2
12toxin-1449.4TNF, IL8
13go 697644 6110.4IL8, TNF, TLR2
14lipoteichoic acid449.4TLR2, TNF, IL8
15polyinosinic-polycytidylic acid449.4TNF, IL8, TLR2
16poly(i-c)449.4IL8, TNF, TLR2
17il 10449.4TLR2, TNF, IL8
18peptidoglycan44 2810.4TNF, IL8, TLR2
19ccl344 2810.4TLR2, IL8, TNF
20azithromycin44 1110.4CFTR, IL8
21leukotriene b444 61 2411.4TLR2, IL8, TNF
22sp 60012544 6110.4TLR2, IL8, TNF
23alpha lipoic acid449.3TNF, SERPINA1, MSRA
24mip 1alpha449.3TNF, IL8
25simvastatin44 50 61 28 24 1114.2TLR2, TNF, IL8
26mg 13244 6110.1CFTR, IL8, TNF
27cytochalasin d44 6110.0CFTR, IL8, SYK
28groalpha448.9TNF, IL8, SYK
29actinomycin d448.9IL8, TNF, CFTR, TLR2
30cyclosporin a44 28 6110.9IL8, TNF, CFTR, TLR2
31pge2448.9CFTR, TLR2, IL8, TNF
32curcumin448.9CFTR, TNF, IL8
33zymosan448.9TLR2, CLEC7A, SYK, TNF
34egcg448.8IL8, TNF, SYK
35endotoxin448.7IL8, TLR2, TNF
36fibrinogen448.7TLR2, SYK, TNF, SERPINA1
37herbimycin a44 619.7SYK, TNF, IL8
38rantes448.6TNF, SYK, IL8, TLR2
39sb 20358044 619.6TLR2, TNF, IL8, SYK
40histamine44 28 2410.6SYK, IL8, TNF, TLR2
41superoxide44 249.5TNF, SYK, IL8, TLR2
42n acetylcysteine448.5IL8, CFTR, TNF, SYK
43genistein44 28 61 2 24 1113.4IL8, TNF, CFTR, SYK
44nitric oxide44 24 1110.2IL8, SYK, SERPINA1, TNF, TLR2
45lipid448.0TNF, TLR2, SYK, SERPINA1, MSRA
46dexamethasone44 50 28 1110.9CLEC7A, TLR2, CFTR, TNF, SYK, IL8
47cysteine447.9CFTR, SYK, IL8, MSRA, SERPINA1, TLR2
48serine447.4SQSTM1, TLR2, CFTR, TNF, SERPINA1, SYK
49oxygen44 248.3MSRA, SYK, SQSTM1, IL8, TLR2, SERPINA1
50h2o2447.3MSRA, IL8, SERPINA1, TNF, CFTR, TLR2

GO Terms for genes affiliated with Mycobacterium Abscessus

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Cellular components related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.1TNF, CFTR, TLR2
2external side of plasma membraneGO:0098978.9CLEC7A, TNF, TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:00275210.2CLEC7A, TLR2
2positive regulation of tumor necrosis factor productionGO:03276010.0TLR2, CLEC7A
3positive regulation of interleukin-18 productionGO:0327419.9TLR2, TNF
4positive regulation of chemokine productionGO:0327229.8TLR2, TNF
5negative regulation of growth of symbiont in hostGO:0441309.8TLR2, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.8TNF, SQSTM1
7positive regulation of NF-kappaB import into nucleusGO:0423469.8TNF, TLR2
8lipopolysaccharide-mediated signaling pathwayGO:0316639.8TLR2, TNF
9positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, TLR2
10defense response to Gram-positive bacteriumGO:0508309.7TNF, TLR2
11cellular response to molecule of fungal originGO:0712269.7CLEC7A, SYK
12leukocyte activation involved in immune responseGO:0023669.7SYK, CLEC7A
13positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.6NLRP3, TNF
14embryonic digestive tract developmentGO:0485669.6IL8, TNF
15positive regulation of interleukin-6 productionGO:0327559.5TNF, TLR2
16positive regulation of NF-kappaB transcription factor activityGO:0510929.5TNF, TLR2, NLRP3
17response to hypoxiaGO:0016669.4SERPINA1, TNF, TLR2
18response to cytokineGO:0340979.3CFTR, SERPINA1
19calcium-mediated signalingGO:0197229.2IL8, TNF
20neutrophil chemotaxisGO:0305939.2SYK, IL8
21positive regulation of cytokine secretionGO:0507159.1TLR2, SYK, TNF
22negative regulation of cell proliferationGO:0082859.0TLR2, TNF, IL8
23innate immune responseGO:0450878.9SYK, NLRP3, CLEC7A, TLR2
24inflammatory responseGO:0069548.7NLRP3, TLR2, TNF, CLEC7A, IL8

Molecular functions related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signaling pattern recognition receptor activityGO:0083299.9TLR2, CLEC7A
2peptidoglycan bindingGO:0428349.7TLR2, NLRP3
3protease bindingGO:0020209.4TNF, SERPINA1
4protein bindingGO:0055156.3TLR2, CFTR, TNF, SERPINA1, IL8, SYK

Products for genes affiliated with Mycobacterium Abscessus

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Sources for Mycobacterium Abscessus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet