MCID: MYC013
MIFTS: 35

Mycobacterium Abscessus malady

Rare diseases category

Aliases & Classifications for Mycobacterium Abscessus

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Aliases & Descriptions for Mycobacterium Abscessus:

Name: Mycobacterium Abscessus 45
Mycobacterium Abscessus Infection 45
 
M. Abscessus 45


Classifications:



Summaries for Mycobacterium Abscessus

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Wikipedia:68 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

MalaCards based summary: Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to mycobacterium fortuitum and cystic fibrosis. An important gene associated with Mycobacterium Abscessus is TLR2 (Toll-Like Receptor 2), and among its related pathways are Disorders of transmembrane transporters and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include lung, skin and cortex, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Related Diseases for Mycobacterium Abscessus

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Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to mycobacterium abscessus

Symptoms for Mycobacterium Abscessus

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Drugs & Therapeutics for Mycobacterium Abscessus

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Drugs for Mycobacterium Abscessus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AzithromycinapprovedPhase 430983905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
2
TigecyclineapprovedPhase 253220620-09-75282044
Synonyms:
(4S,12aS)-4,7-Bis(dimethylamino)-9-{2-[(tert-butyl)amino]acetylamino}-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide
(4S,4AS,5ar,12as)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
(4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
121GE002
220620-09-7
9-t-Butylglycylamido minocycline
AC-1798
AC1NQZEU
C12012
CHEBI:149836
CHEMBL1212946
CHEMBL376140
CID5282044
D01079
DB00560
GAR 936
GAR-936
 
GAR-936,Tigecycline
LS-186580
LS-187002
LS-187782
N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide
S1403_Selleck
TBG-MINO
Tigeciclina
Tigecycline
Tigecycline (JAN/USAN)
Tigecycline [USAN]
Tigecyclinum
Tigilcycline
Tygacil
Tygacil (TN)
Tygacil(TM)
Tygacil, GAR-936, WAY-GAR-936, TBG-MINO, Tigecycline
UNII-70JE2N95KR
WAY-GAR-936

Interventional clinical trials:

idNameStatusNCT IDPhase
1Azithromycin in the Treatment of M. Avium Complex Lung DiseaseActive, not recruitingNCT00599079Phase 4
2Tigecycline for Treatment of Rapidly Growing MycobacteriaActive, not recruitingNCT00600600Phase 2
3Inhaled Amikacin Treatment for Nontuberculous Mycobacterial Lung DiseaseWithdrawnNCT01528930Phase 2
4The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung DiseaseRecruitingNCT02005094
5The Incidence of Nontuberculous Mycobacterial Pulmonary Infection in Bilateral Bronchiectasis and BronchiolitisRecruitingNCT01354912
6PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic FibrosisRecruitingNCT02419989

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

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Anatomical Context for Mycobacterium Abscessus

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MalaCards organs/tissues related to Mycobacterium Abscessus:

33
Lung, Skin, Cortex, Testes, Breast, Colon, T cells

Animal Models for Mycobacterium Abscessus or affiliated genes

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MGI Mouse Phenotypes related to Mycobacterium Abscessus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3CFTR, NLRP3, SQSTM1, SYK, TLR2, TNF
2MP:00053818.3CFTR, CLEC7A, NLRP3, TLR2, TNF
3MP:00053888.1CFTR, CLEC7A, SYK, TLR2, TNF
4MP:00053847.7CFTR, MSRA, NLRP3, SQSTM1, SYK, TLR2
5MP:00107686.8CFTR, CLEC7A, MSRA, NLRP3, SQSTM1, SYK
6MP:00053766.6CFTR, CLEC7A, MSRA, NLRP3, SQSTM1, SYK
7MP:00053976.3CFTR, CLEC7A, CXCL8, NLRP3, SQSTM1, SYK
8MP:00053876.0CFTR, CLEC7A, CXCL8, NLRP3, SQSTM1, SYK

Publications for Mycobacterium Abscessus

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Articles related to Mycobacterium Abscessus:

(show top 50)    (show all 379)
idTitleAuthorsYear
1
Susceptibility testing of Mycobacterium abscessus by isothermal microcalorimetry. (26210204)
2015
2
Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells. (25638774)
2015
3
Rapid detection and immune characterization of Mycobacterium abscessus infection in cystic fibrosis patients. (25742660)
2015
4
Utility of Sequencing the erm(41) Gene in Isolates of Mycobacterium abscessus subsp. abscessus with Low and Intermediate Clarithromycin MICs. (25653399)
2015
5
Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates. (26210507)
2015
6
Separation of Mycobacterium abscessus into subspecies or genotype level by direct application of peptide nucleic acid multi-probe- real-time PCR method into sputa samples. (26259717)
2015
7
Essential Engagement of Toll-Like Receptor 2 in Initiation of Early Protective Th1 Response against Rough Variants of Mycobacterium abscessus. (25644006)
2015
8
Risk Factors for Mycobacterium abscessus subsp. bolletii infection after laparoscopic surgery during an outbreak in Brazil. (25627765)
2015
9
Mycobacterium abscessus skin infection after tattooing - Case report. (26560222)
2015
10
Management of Mycobacterium abscessus Post Abdominoplasty. (25338711)
2014
11
Classification algorithm for subspecies identification within the Mycobacterium abscessus species, based on matrix-assisted laser desorption ionization-time of flight mass spectrometry. (25009048)
2014
12
Inhaled therapies, azithromycin and Mycobacterium abscessus in cystic fibrosis patients. (22936714)
2013
13
Endovascular Mycobacterium abscessus infection in a heart transplant recipient: a case report and review of the literature. (23176090)
2013
14
Whole-Genome Shotgun Sequencing of Mycobacterium abscessus M156, an Emerging Clinical Pathogen in Malaysia. (23405341)
2013
15
Adherence and biofilm formation of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium abscessus to household plumbing materials. (23742161)
2013
16
Probable disseminated Mycobacterium abscessus subspecies bolletii infection in a patient with idiopathic CD4+ T lymphocytopenia: a case report. (22947084)
2012
17
Molecular typing of Mycobacterium abscessus based on tandem-repeat polymorphism. (22760048)
2012
18
Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic fibrosis center. (22246710)
2012
19
Mycobacterium abscessus pneumonia in an Atlantic bottlenose dolphin (Tursiops truncatus). (23272373)
2012
20
Strategies to improve outcome of drug treatment for Mycobacterium abscessus pulmonary disease. (21364074)
2011
21
Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. (21292659)
2011
22
Diversity of pulsed-field gel electrophoresis patterns of Mycobacterium abscessus type 2 clinical isolates. (21084521)
2011
23
Diagnosis of pulmonary disease caused by Mycobacterium abscessus: a case report. (21819731)
2011
24
Disseminated Mycobacterium abscessus infection and showerheads, Taiwan. (22099106)
2011
25
Mycobacterium abscessus: a new player in the mycobacterial field. (20060723)
2010
26
Mycobacterium abscessus infection in transplant recipients. (20970610)
2010
27
Fatal Mycobacterium abscessus endocarditis misidentified as Corynebacterium spp. (19958237)
2010
28
Successful treatment of a prosthetic joint infection due to Mycobacterium abscessus. (20808461)
2009
29
Community-acquired mastitis due to Mycobacterium abscessus: a case report. (20062768)
2009
30
Unresolving furunculosis in a diabetic patient: cutaneous Mycobacterium abscessus infection. (19271048)
2009
31
Mycobacterium abscessus endocarditis: a case report and literature review. (19073380)
2008
32
Disseminated cutaneous infection with Mycobacterium abscessus in a patient with a low CD4+ T cell count. (18474467)
2008
33
Paradoxical worsening of pulmonary Mycobacterium abscessus. (17293101)
2007
34
Use of PCR-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by Mycobacterium abscessus and Mycobacterium chelonae. (16414212)
2006
35
Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolates. (16529900)
2006
36
Multiple subcutaneous nodules associate with Mycobacterium abscessus infection following removal of an infected Groshon vascular catheter tip. (17083867)
2006
37
Disseminated mycobacterium abscessus infection in a hemodialysis patient with acquired reactive perforating collagenosis--a case study and literature review. (15678699)
2005
38
In vitro activity of fluoroquinolones against Mycobacterium abscessus and Mycobacterium chelonae causing infectious keratitis after LASIK in Brazil. (16015094)
2005
39
Infection with mycobacterium abscessus after Mohs micrographic surgery in an immunocompetent patient. (16029710)
2005
40
Cutaneous Mycobacterium abscessus infection after kidney transplantation. (15755761)
2005
41
Pneumonia due to Mycobacterium abscessus in two domestic ferrets (Mustelo putorius furo). (16164141)
2005
42
Mycobacterium abscessus as a cause of pacemaker infection. (15448601)
2004
43
Therapeutic keratectomy for Mycobacterium abscessus keratitis after LASIK. (14724729)
2003
44
Disseminated Mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis: case report and literature review. (11173189)
2001
45
DNA polymorphism of Mycobacterium abscessus analyzed by infrequent-restriction-site polymerase chain reaction. (11039248)
2000
46
Mycobacterium abscessus peritonitis: a case report. (10182108)
1998
47
A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae. (9607835)
1998
48
Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. (8807061)
1996
49
Differentiation between Mycobacterium abscessus and Mycobacterium borstelense. (4244292)
1970
50
Comparison of the pathogenicity for mice of Mycobacterium fortuitum and Mycobacterium abscessus. (5370281)
1969

Variations for Mycobacterium Abscessus

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Expression for genes affiliated with Mycobacterium Abscessus

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Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for genes affiliated with Mycobacterium Abscessus

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Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CFTR, NLRP3
29.3CXCL8, TNF
39.3CXCL8, TNF
49.2TLR1, TLR2, TNF
5
Show member pathways
9.2TLR1, TLR2, TNF
69.1SQSTM1, SYK, TNF
79.0CXCL8, TLR2, TNF
89.0CXCL8, TLR2, TNF
99.0CXCL8, TLR2, TNF
109.0CXCL8, TLR2, TNF
119.0CLEC7A, TLR1, TLR2
129.0CXCL8, SYK, TNF
13
Show member pathways
8.9CXCL8, NLRP3, TNF
148.9CXCL8, NLRP3, TNF
158.9CXCL8, NLRP3, TNF
16
Show member pathways
8.7CXCL8, TLR1, TLR2, TNF
17
Show member pathways
8.6CXCL8, NLRP3, TLR2, TNF
18
Show member pathways
8.4CFTR, CXCL8, TLR1, TLR2, TNF
198.0CLEC7A, SYK, TLR1, TLR2, TNF
208.0CLEC7A, SYK, TLR1, TLR2, TNF
21
Show member pathways
7.2CLEC7A, NLRP3, SQSTM1, SYK, TLR1, TLR2
22
Show member pathways
6.7CFTR, CLEC7A, CXCL8, NLRP3, SYK, TLR1

GO Terms for genes affiliated with Mycobacterium Abscessus

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Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:00353549.8TLR1, TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:004249510.4TLR1, TLR2
2positive regulation of tumor necrosis factor biosynthetic processGO:004253510.4TLR1, TLR2
3cellular response to triacyl bacterial lipopeptideGO:007172710.4TLR1, TLR2
4positive regulation of chemokine productionGO:003272210.2TLR2, TNF
5positive regulation of NF-kappaB import into nucleusGO:004234610.1TLR2, TNF
6lipopolysaccharide-mediated signaling pathwayGO:003166310.1TLR2, TNF
7positive regulation of interleukin-8 productionGO:003275710.1TLR2, TNF
8response to molecule of fungal originGO:000223810.1CLEC7A, TLR2
9regulation of tumor necrosis factor-mediated signaling pathwayGO:001080310.1SYK, TNF
10cell surface pattern recognition receptor signaling pathwayGO:000275210.0CLEC7A, TLR2
11regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.9SQSTM1, TNF
12leukocyte activation involved in immune responseGO:00023669.9CLEC7A, SYK
13cellular response to molecule of fungal originGO:00712269.9CLEC7A, SYK
14positive regulation of cytokine secretionGO:00507159.8SYK, TLR2, TNF
15embryonic digestive tract developmentGO:00485669.7CXCL8, TNF
16positive regulation of nitric oxide biosynthetic processGO:00454299.7TLR2, TNF
17negative regulation of growth of symbiont in hostGO:00441309.6SQSTM1, TLR2, TNF
18positive regulation of NF-kappaB transcription factor activityGO:00510929.6NLRP3, TLR2, TNF
19positive regulation of phagocytosisGO:00507669.4CLEC7A, TNF
20defense responseGO:00069529.3NLRP3, TLR1, TNF
21cellular response to lipopolysaccharideGO:00712229.3CXCL8, NLRP3, TNF
22immune responseGO:00069558.9CXCL8, TLR1, TLR2, TNF
23innate immune responseGO:00450878.2CLEC7A, NLRP3, SYK, TLR1, TLR2
24inflammatory responseGO:00069547.8CLEC7A, CXCL8, NLRP3, TLR1, TLR2, TNF

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:00428349.7NLRP3, TLR2
2signaling pattern recognition receptor activityGO:00083299.4CLEC7A, TLR2

Sources for Mycobacterium Abscessus

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet