MCID: MYC013
MIFTS: 44

Mycobacterium Abscessus malady

Summaries for Mycobacterium Abscessus

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64Wikipedia, 33MalaCards
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Wikipedia:64 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

MalaCards: Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to cystic fibrosis and arthritis. An important gene associated with Mycobacterium Abscessus is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are EBV LMP1 signaling and Immune response MIF-mediated glucocorticoid regulation. The compounds muramyl dipeptide and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Mycobacterium Abscessus

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

mycobacterium abscessus 43
mycobacterium abscessus infection 43
m. abscessus 43


Related Diseases for Mycobacterium Abscessus

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis31.3SERPINA1, CFTR, IL8
2arthritis30.6TNF, IL8, SERPINA1
3uveitis30.2TNF
4tuberculosis30.2TLR2, TNF, CLEC7A, SERPINA1
5sepsis30.2TLR2, TNF, IL8
6mycobacterium chelonae10.9
7mycobacterium fortuitum10.6
8bacteremia10.4
9mycobacterium avium complex disease10.3
10epidural abscess10.3
11corneal abscess10.3
12pulmonary tuberculosis10.2
13cellulitis10.2
14stevens-johnson syndrome10.2
15gamma chain deficiency10.2
16septic arthritis10.2
17adrenal cortex disease10.2
18aspiration pneumonia10.2
19anterior uveitis10.2
20prosthetic joint infection10.2
21mycobacterium kansasii10.2
22measles10.0TLR2
23aspergillosis10.0TLR2
24atopy10.0TLR2
25urticaria10.0NLRP3
26pulmonary disease, chronic obstructive10.0SERPINA1
27pyoderma gangrenosum10.0NLRP3
28alpha 1-antitrypsin deficiency10.0SERPINA1
29dermatitis10.0NLRP3
30hepatitis b10.0SERPINA1
31gastric ulcer10.0TLR2
32gout10.0NLRP3
33conjunctivitis10.0NLRP3
34keratitis10.0TLR2
35atopic dermatitis10.0TLR2
36otitis media10.0TLR2
37fibromyalgia10.0SERPINA1
38muckle-wells syndrome10.0NLRP3
39acute myocardial infarction10.0SERPINA1
40paget's disease of bone10.0SQSTM1
41wegener's granulomatosis10.0SERPINA1
42prostate cancer10.0SQSTM1
43multiple system atrophy10.0SQSTM1
44colorectal cancer10.0SERPINA1
45infertility10.0CFTR
46ulcerative colitis10.0TNF
47pouchitis10.0TLR2
48crohn's disease10.0TNF
49influenza10.0CFTR
50leprosy10.0TLR2

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to mycobacterium abscessus

Clinical Features for Mycobacterium Abscessus

Drugs & Therapeutics for Mycobacterium Abscessus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mycobacterium Abscessus

Drug clinical trials:

Search ClinicalTrials for Mycobacterium Abscessus

Search NIH Clinical Center for Mycobacterium Abscessus

Search CenterWatch for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

Anatomical Context for Mycobacterium Abscessus

Sources:
33MalaCards
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MalaCards organs/tissues related to Mycobacterium Abscessus:

33
Skin, Liver, Kidney, Lung, Whole blood, Cortex, Heart, Colon, Breast, Prostate, T cells, Endothelial, Adrenal cortex

Animal Models for Mycobacterium Abscessus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Mycobacterium Abscessus

Sources:
51PubMed
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Articles related to Mycobacterium Abscessus:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Inhaled therapies, azithromycin and Mycobacterium abscessus in cystic fibrosis patients. (22936714)
2013
2
Whole-Genome Shotgun Sequencing of Mycobacterium abscessus M156, an Emerging Clinical Pathogen in Malaysia. (23405341)
2013
3
Serodiagnosis of Mycobacterium avium complex and Mycobacterium abscessus complex pulmonary disease by use of IgA antibodies to glycopeptidolipid core antigen. (23740728)
2013
4
Further isolation of Mycobacterium abscessus subsp. abscessus and subsp. bolletii in different regions of Japan and susceptibility of these isolates to antimicrobial agents. (23850022)
2013
5
New rapid scheme for distinguishing the subspecies of the Mycobacterium abscessus group and identifying Mycobacterium massiliense isolates with inducible clarithromycin resistance. (23804391)
2013
6
Probable disseminated Mycobacterium abscessus subspecies bolletii infection in a patient with idiopathic CD4+ T lymphocytopenia: a case report. (22947084)
2012
7
Risk factors for Mycobacterium abscessus infection in cystic fibrosis patients; a case-control study. (22342403)
2012
8
Phenotypic and molecular characterization of quinolone resistance in Mycobacterium abscessus subsp. bolletii recovered from postsurgical infections. (21903825)
2012
9
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1. (21876553)
2012
10
Serial CT findings of Mycobacterium massiliense pulmonary disease compared with Mycobacterium abscessus disease after treatment with antibiotic therapy. (22371609)
2012
11
Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. (21292659)
2011
12
Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae. (21486854)
2011
13
Multilocus sequence analysis and rpoB sequencing of Mycobacterium abscessus (sensu lato) strains. (21106786)
2011
14
Genetic analysis of new 16S rRNA mutations conferring aminoglycoside resistance in Mycobacterium abscessus. (21652621)
2011
15
Mycobacterium abscessus infection complicating a professional tattoo. (21198529)
2010
16
An outbreak of skin and soft tissue infection caused by Mycobacterium abscessus following acupuncture. (19694761)
2010
17
Oral moxifloxacin and topical amikacin for Mycobacterium abscessus keratitis after laser in situ keratomileusis. (20457379)
2010
18
Sequential bilateral lung resection in a patient with Mycobacterium abscessus lung disease refractory to medical treatment. (20046529)
2010
19
Aerosolized amikacin and oral clarithromycin to eradicate Mycobacterium abscessus in a patient with cystic fibrosis: an 8-year follow-up. (20503290)
2010
20
Rare complication after stripping operation: a case report of mycobacterium abscessus infection. (23555416)
2010
21
Mycobacterium abscessus Hand Infections in Immunocompetent Fish Handlers: Case Report. (20610060)
2010
22
A case of Mycobacterium abscessus skin infection caused by multiple acupunctures. (19758379)
2010
23
Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients. (19661243)
2009
24
Mycobacterium abscessus infection in solid organ transplant recipients: report of three cases and review of the literature. (19671119)
2009
25
Arteriovenous graft infection caused by Mycobacterium abscessus in a hemodialysis patient. (19356386)
2009
26
Inaccuracy of single-target sequencing for discriminating species of the Mycobacterium abscessus group. (19515839)
2009
27
The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. (19097985)
2009
28
Characterization of mycobacteria from a major Brazilian outbreak suggests that revision of the taxonomic status of members of the Mycobacterium chelonae-M. abscessus group is needed. (19571015)
2009
29
Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1. (18373632)
2008
30
Pseudo-outbreak of Mycobacterium abscessus Infection Caused by laboratory contamination . (18171188)
2008
31
An autopsy case of Mycobacterium abscessus pulmonary infection complicated with rheumatoid arthritis. (18591855)
2008
32
Evaluation of BacT/Alert 3D SA bottles for accurate detection of Mycobacteremia with special reference to Mycobacterium abscessus. (17363357)
2007
33
Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL/6 mice. (17875636)
2007
34
Cutaneous Infection with Mycobacterium abscessus in a child. (16650219)
2006
35
In vitro activity of fluoroquinolones against Mycobacterium abscessus and Mycobacterium chelonae causing infectious keratitis after LASIK in Brazil. (16015094)
2005
36
Cutaneous Mycobacterium abscessus infection after kidney transplantation. (15755761)
2005
37
Pneumonia due to Mycobacterium abscessus in two domestic ferrets (Mustelo putorius furo). (16164141)
2005
38
Mycobacterium chelonae-Mycobacterium abscessus complex clear corneal wound infection with recurrent hypopyon and perforation after phacoemulsification and intraocular lens implantation. (16105623)
2005
39
Successful treatment with faropenem and clarithromycin of pulmonary Mycobacterium abscessus infection. (12373490)
2002
40
Lack of transmission of mycobacterium abscessus among patients with cystic fibrosis attending a single clinic. (11340540)
2001
41
Neurologic manifestations of disseminated infection with Mycobacterium abscessus. (11274327)
2001
42
Mastitis due to Mycobacterium abscessus after body piercing. (11389508)
2001
43
Mycobacterium immunogenum sp. nov., a novel species related to Mycobacterium abscessus and associated with clinical disease, pseudo-outbreaks and contaminated metalworking fluids: an international cooperative study on mycobacterial taxonomy. (11594606)
2001
44
Mycobacterium abscessus: a cutaneous infection in a patient on renal replacement therapy. (11488830)
2001
45
Mycobacterium abscessus osteomyelitis following a plantar puncture wound. (8879805)
1996
46
Chronic endophthalmitis after extracapsular cataract extraction caused by Mycobacterium chelonae subspecies abscessus. (8849553)
1995
47
DNA large restriction fragment patterns of sporadic and epidemic nosocomial strains of Mycobacterium chelonae and Mycobacterium abscessus. (8253968)
1993
48
An inguinal bubo caused by Mycobacterium chelonae abscessus. (1286124)
1992
49
In vitro susceptibility of Mycobacterium fortuitum, M. abscessus and M. borstelense to vancomycin. (4787739)
1973
50
Differentiation between Mycobacterium abscessus and Mycobacterium borstelense. (4244292)
1970

Genetic Variations for Mycobacterium Abscessus

Expression for genes affiliated with Mycobacterium Abscessus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for genes affiliated with Mycobacterium Abscessus

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology, 30KEGG, 54Reactome, 53R&D Systems
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Compounds for genes affiliated with Mycobacterium Abscessus

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1muramyl dipeptide45 2911.0TLR2, IL8
2hbd2459.9TLR2, IL8
3dexamethasone45 50 29 1112.8CFTR, CLEC7A, TLR2
4anakinra45 1110.8NLRP3, TNF
5azithromycin45 1110.7IL8, CFTR
6cilomilast459.7TNF, IL8
7n-tosyl-l-phenylalanine chloromethyl ketone459.7TNF, IL8
8taurine chloramine459.6IL8, TNF
9hcec459.6TLR2, IL8
10toxin-1459.6TNF, IL8
11ulinastatin459.6TNF, IL8
12mip 1alpha459.5TNF, IL8
13monosodium urate459.5SYK, IL8
14imiquimod45 29 60 1112.5TLR2, TNF, IL8
15polymyxin b459.4IL8, TNF, TLR2
16go 697645 6010.4IL8, TNF, TLR2
17lipoteichoic acid459.4TLR2, TNF, IL8
18polyinosinic-polycytidylic acid459.4IL8, TNF, TLR2
19poly(i-c)459.4IL8, TNF, TLR2
20il 10459.4IL8, TNF, TLR2
21peptidoglycan45 2910.4IL8, TNF, TLR2
22ccl345 2910.4TLR2, TNF, IL8
23gold sodium thiomalate459.4IL8, TNF
24leukotriene b445 60 2411.4IL8, TNF, TLR2
25alpha lipoic acid459.4TNF, MSRA, SERPINA1
26sp 60012545 6010.4TLR2, TNF, IL8
27fmlp459.4SYK
28superoxide45 2410.3TNF, SYK
29simvastatin45 50 60 29 11 2414.2IL8, TNF, TLR2
30h2o2459.1SYK, CFTR, MSRA
31rantes459.1TLR2, TNF, SYK
32mg 13245 6010.1CFTR, IL8, TNF
33cytochalasin d45 6010.0CFTR, IL8, SYK
34groalpha458.9TNF, SYK, IL8
35actinomycin d458.9TLR2, TNF, IL8, CFTR
36cyclosporin a45 29 6010.9CFTR, IL8, TNF, TLR2
37zymosan458.9CLEC7A, SYK, TNF, TLR2
38egcg458.8TNF, SYK, IL8
39curcumin458.8CFTR, IL8, TNF
40fibrinogen458.7SERPINA1, SYK, TNF, TLR2
41herbimycin a45 609.6TNF, SYK, IL8
42sb 20358045 609.6TLR2, TNF, SYK, IL8
43histamine45 29 2410.6TLR2, TNF, SYK, IL8
44n acetylcysteine458.5TNF, SYK, IL8, CFTR
45genistein45 29 60 2 11 2413.4TNF, SYK, IL8, CFTR
46serine458.2TLR2, TNF, SQSTM1, SYK, IL8
47nitric oxide45 11 2410.2SERPINA1, IL8, SYK, TNF, TLR2
48cysteine457.9TLR2, SYK, IL8, CFTR, MSRA, SERPINA1
49lipid457.8TNF, SYK, MSRA, SERPINA1, TLR2
50oxygen45 248.3TLR2, TNF, SQSTM1, SYK, IL8, MSRA

GO Terms for genes affiliated with Mycobacterium Abscessus

Sources:
16Gene Ontology
See all sources

Cellular components related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2CLEC7A, TNF, TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:00275210.1TLR2, CLEC7A
2negative regulation of growth of symbiont in hostGO:0441309.8TLR2, TNF
3positive regulation of tumor necrosis factor productionGO:0327609.8TLR2, CLEC7A
4positive regulation of chemokine productionGO:0327229.7TNF, TLR2
5regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7TNF, SQSTM1
6positive regulation of NF-kappaB import into nucleusGO:0423469.7TNF, TLR2
7cellular response to molecule of fungal originGO:0712269.6SYK, CLEC7A
8leukocyte activation involved in immune responseGO:0023669.6CLEC7A, SYK
9lipopolysaccharide-mediated signaling pathwayGO:0316639.6TNF, TLR2
10positive regulation of nitric oxide biosynthetic processGO:0454299.5TNF, TLR2
11defense response to Gram-positive bacteriumGO:0508309.5TNF, TLR2
12embryonic digestive tract developmentGO:0485669.5IL8, TNF
13positive regulation of NF-kappaB transcription factor activityGO:0510929.4TNF, TLR2, NLRP3
14positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.2TNF, NLRP3
15positive regulation of cytokine secretionGO:0507159.0TLR2, TNF, SYK
16innate immune responseGO:0450878.8NLRP3, TLR2, SYK, CLEC7A
17inflammatory responseGO:0069548.7IL8, CLEC7A, TNF, TLR2, NLRP3

Molecular functions related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signaling pattern recognition receptor activityGO:0083299.8CLEC7A, TLR2
2peptidoglycan bindingGO:0428349.5TLR2, NLRP3
3protein bindingGO:0055156.6TLR2, TNF, SQSTM1, SYK, IL8, CFTR

Products for genes affiliated with Mycobacterium Abscessus

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  • Proteins
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  • Antibodies

Sources for Mycobacterium Abscessus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet