MCID: MYC013
MIFTS: 50

Mycobacterium Abscessus malady

Rare diseases category
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Summaries for Mycobacterium Abscessus

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65Wikipedia, 33MalaCards
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Wikipedia:65 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

MalaCards: Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to cystic fibrosis and mastitis. An important gene associated with Mycobacterium Abscessus is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are IL-17 Family Signaling Pathways and Selected targets of GCR alpha. The compounds muramyl dipeptide and anakinra have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Mycobacterium Abscessus

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43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

mycobacterium abscessus 43
mycobacterium abscessus infection 43
m. abscessus 43


Related Diseases for Mycobacterium Abscessus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to mycobacterium abscessus

Symptoms for Mycobacterium Abscessus

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Drugs & Therapeutics for Mycobacterium Abscessus

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mycobacterium Abscessus

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

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Anatomical Context for Mycobacterium Abscessus

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33MalaCards
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MalaCards organs/tissues related to Mycobacterium Abscessus:

33
Lung, Testes, Skin, Breast, Colon, T cells, Adrenal cortex, Cortex, Liver, Kidney, Prostate, Heart, Endothelial, Eye

Animal Models for Mycobacterium Abscessus or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mycobacterium Abscessus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3TLR2, CFTR, TNF, CLEC7A, NLRP3
2MP:00053888.0TLR2, CFTR, TNF, CLEC7A, SYK
3MP:00053787.8NLRP3, SQSTM1, MSRA, TNF, CFTR, TLR2
4MP:00053707.7TLR2, CFTR, TNF, SYK, SQSTM1, NLRP3
5MP:00053907.7TLR2, TNF, SYK, SQSTM1, NLRP3
6MP:00053847.1TLR2, CFTR, TNF, MSRA, SYK, SQSTM1
7MP:00053976.9NLRP3, TLR2, CFTR, TNF, CLEC7A, IL8
8MP:00053876.9TLR2, CFTR, TNF, CLEC7A, IL8, SYK
9MP:00053766.9TLR2, CFTR, TNF, CLEC7A, MSRA, SYK
10MP:00107686.8TLR2, CFTR, TNF, CLEC7A, MSRA, SYK

Publications for Mycobacterium Abscessus

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52PubMed
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Articles related to Mycobacterium Abscessus:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Inhaled therapies, azithromycin and Mycobacterium abscessus in cystic fibrosis patients. (22936714)
2013
2
Endovascular Mycobacterium abscessus infection in a heart transplant recipient: a case report and review of the literature. (23176090)
2013
3
Whole-Genome Shotgun Sequencing of Mycobacterium abscessus M156, an Emerging Clinical Pathogen in Malaysia. (23405341)
2013
4
Adherence and biofilm formation of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium abscessus to household plumbing materials. (23742161)
2013
5
Multilocus sequence typing scheme for the Mycobacterium abscessus complex. (24384536)
2013
6
Comparative drug resistance of Mycobacterium abscessus and M. chelonae isolates from patients with and without cystic fibrosis in the United Kingdom. (23135941)
2013
7
Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival. (23451220)
2013
8
Mycobacterium abscessus complex lung infection in a toddler with a tracheostomy. (23460506)
2013
9
Molecular typing of Mycobacterium abscessus based on tandem-repeat polymorphism. (22760048)
2012
10
Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic fibrosis center. (22246710)
2012
11
Mycobacterium abscessus pneumonia in an Atlantic bottlenose dolphin (Tursiops truncatus). (23272373)
2012
12
Strategies to improve outcome of drug treatment for Mycobacterium abscessus pulmonary disease. (21364074)
2011
13
Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. (21292659)
2011
14
Diversity of pulsed-field gel electrophoresis patterns of Mycobacterium abscessus type 2 clinical isolates. (21084521)
2011
15
Diagnosis of pulmonary disease caused by Mycobacterium abscessus: a case report. (21819731)
2011
16
Disseminated Mycobacterium abscessus infection and showerheads, Taiwan. (22099106)
2011
17
Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response. (21292749)
2011
18
Proposal that Mycobacterium massiliense and Mycobacterium bolletii be united and reclassified as Mycobacterium abscessus subsp. bolletii comb. nov., designation of Mycobacterium abscessus subsp. abscessus subsp. nov. and emended description of Mycobacterium abscessus. (21037035)
2011
19
Mycobacterium abscessus: a new player in the mycobacterial field. (20060723)
2010
20
Mycobacterium abscessus infection in transplant recipients. (20970610)
2010
21
Fatal Mycobacterium abscessus endocarditis misidentified as Corynebacterium spp. (19958237)
2010
22
An oxidative environment promotes growth of Mycobacterium abscessus. (20807564)
2010
23
Genetic manipulation of Mycobacterium abscessus. (20812214)
2010
24
Successful treatment of a prosthetic joint infection due to Mycobacterium abscessus. (20808461)
2009
25
Community-acquired mastitis due to Mycobacterium abscessus: a case report. (20062768)
2009
26
Unresolving furunculosis in a diabetic patient: cutaneous Mycobacterium abscessus infection. (19271048)
2009
27
Mycobacterium abscessus from respiratory isolates: activities of drug combinations. (19280301)
2009
28
Mycobacterium abscessus endocarditis: a case report and literature review. (19073380)
2008
29
Disseminated cutaneous infection with Mycobacterium abscessus in a patient with a low CD4+ T cell count. (18474467)
2008
30
Mycobacterium abscessus, an uncommon cause of chronic otitis media: a case report and literature review. (18794448)
2008
31
Paradoxical worsening of pulmonary Mycobacterium abscessus. (17293101)
2007
32
Hypervirulence of a rough variant of the Mycobacterium abscessus type strain. (17145951)
2007
33
Use of PCR-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by Mycobacterium abscessus and Mycobacterium chelonae. (16414212)
2006
34
Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolates. (16529900)
2006
35
Multiple subcutaneous nodules associate with Mycobacterium abscessus infection following removal of an infected Groshon vascular catheter tip. (17083867)
2006
36
Disseminated mycobacterium abscessus infection in a hemodialysis patient with acquired reactive perforating collagenosis--a case study and literature review. (15678699)
2005
37
In vitro activity of fluoroquinolones against Mycobacterium abscessus and Mycobacterium chelonae causing infectious keratitis after LASIK in Brazil. (16015094)
2005
38
Infection with mycobacterium abscessus after Mohs micrographic surgery in an immunocompetent patient. (16029710)
2005
39
Cutaneous Mycobacterium abscessus infection after kidney transplantation. (15755761)
2005
40
Pneumonia due to Mycobacterium abscessus in two domestic ferrets (Mustelo putorius furo). (16164141)
2005
41
Mycobacterium abscessus as a cause of pacemaker infection. (15448601)
2004
42
Therapeutic keratectomy for Mycobacterium abscessus keratitis after LASIK. (14724729)
2003
43
Disseminated Mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis: case report and literature review. (11173189)
2001
44
DNA polymorphism of Mycobacterium abscessus analyzed by infrequent-restriction-site polymerase chain reaction. (11039248)
2000
45
Treatment of refractory disseminated Mycobacterium abscessus infection with interferon gamma therapy. (10052395)
1999
46
Mycobacterium abscessus peritonitis: a case report. (10182108)
1998
47
A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae. (9607835)
1998
48
Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. (8807061)
1996
49
Differentiation between Mycobacterium abscessus and Mycobacterium borstelense. (4244292)
1970
50
Comparison of the pathogenicity for mice of Mycobacterium fortuitum and Mycobacterium abscessus. (5370281)
1969

Variations for Mycobacterium Abscessus

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Expression for genes affiliated with Mycobacterium Abscessus

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for genes affiliated with Mycobacterium Abscessus

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Sources:
50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 30KEGG
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Pathways related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7TLR2, CFTR
29.6TLR2, IL8
39.6SERPINA1, CFTR
49.5TLR2, TNF
5
Show member pathways
IL27-mediated signaling events38
9.5TNF, TLR2
6
Show member pathways
9.5CFTR, IL8
7
Show member pathways
9.5CFTR, IL8
89.5TNF, SQSTM1
9
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.5SQSTM1, TNF
109.3TNF, IL8
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.3IL8, TNF
129.3IL8, TNF
139.3IL8, TNF
149.2TLR2, TNF, CLEC7A
159.0IL8, TNF, TLR2
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0TLR2, IL8, TNF
179.0IL8, TNF, TLR2
189.0TLR2, TNF, IL8
199.0TLR2, TNF, IL8
20
Show member pathways
9.0NLRP3, IL8, TNF
219.0IL8, TNF, NLRP3
22
Show member pathways
8.7TLR2, SYK, TNF
23
Show member pathways
8.7IL8, TNF, TLR2, NLRP3
248.7SYK, SQSTM1, TNF
25
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.6CFTR, TLR2, IL8, TNF
268.5SYK, TNF, IL8
278.4TNF, SYK, CLEC7A, TLR2
28
Show member pathways
8.2TNF, IL8, SYK, TLR2
29
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.1TNF, SYK, IL8, CLEC7A, CFTR, TLR2

Compounds for genes affiliated with Mycobacterium Abscessus

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1muramyl dipeptide45 2911.0TLR2, IL8
2anakinra45 1110.8NLRP3, TNF
3hbd2459.7TLR2, IL8
4cilomilast459.7IL8, TNF
5n-tosyl-l-phenylalanine chloromethyl ketone459.6TNF, IL8
6taurine chloramine459.6TNF, IL8
7gabexate mesilate459.6IL8, TNF
8ulinastatin459.5IL8, TNF
9monosodium urate459.5SYK, IL8
10imiquimod45 61 29 1112.5IL8, TLR2, TNF
11polymyxin b459.4IL8, TNF, TLR2
12toxin-1459.4TNF, IL8
13go 697645 6110.4IL8, TNF, TLR2
14lipoteichoic acid459.4TLR2, TNF, IL8
15polyinosinic-polycytidylic acid459.4TNF, IL8, TLR2
16poly(i-c)459.4IL8, TNF, TLR2
17il 10459.4TLR2, TNF, IL8
18peptidoglycan45 2910.4TNF, IL8, TLR2
19ccl345 2910.4TLR2, IL8, TNF
20azithromycin45 1110.4CFTR, IL8
21leukotriene b445 61 2411.4TLR2, IL8, TNF
22sp 60012545 6110.4TLR2, IL8, TNF
23alpha lipoic acid459.3TNF, SERPINA1, MSRA
24mip 1alpha459.3TNF, IL8
25simvastatin45 51 61 29 24 1114.2TLR2, TNF, IL8
26mg 13245 6110.1CFTR, IL8, TNF
27cytochalasin d45 6110.0CFTR, IL8, SYK
28groalpha458.9TNF, IL8, SYK
29actinomycin d458.9IL8, TNF, CFTR, TLR2
30cyclosporin a45 29 6110.9IL8, TNF, CFTR, TLR2
31pge2458.9CFTR, TLR2, IL8, TNF
32curcumin458.9CFTR, TNF, IL8
33zymosan458.9TLR2, CLEC7A, SYK, TNF
34egcg458.8IL8, TNF, SYK
35endotoxin458.7IL8, TLR2, TNF
36fibrinogen458.7TLR2, SYK, TNF, SERPINA1
37herbimycin a45 619.7SYK, TNF, IL8
38rantes458.6TNF, SYK, IL8, TLR2
39sb 20358045 619.6TLR2, TNF, IL8, SYK
40histamine45 29 2410.6SYK, IL8, TNF, TLR2
41superoxide45 249.5TNF, SYK, IL8, TLR2
42n acetylcysteine458.5IL8, CFTR, TNF, SYK
43genistein45 29 61 3 24 1113.4IL8, TNF, CFTR, SYK
44nitric oxide45 24 1110.2IL8, SYK, SERPINA1, TNF, TLR2
45lipid458.0TNF, TLR2, SYK, SERPINA1, MSRA
46dexamethasone45 51 29 1110.9CLEC7A, TLR2, CFTR, TNF, SYK, IL8
47cysteine457.9CFTR, SYK, IL8, MSRA, SERPINA1, TLR2
48serine457.4SQSTM1, TLR2, CFTR, TNF, SERPINA1, SYK
49oxygen45 248.3MSRA, SYK, SQSTM1, IL8, TLR2, SERPINA1
50h2o2457.3MSRA, IL8, SERPINA1, TNF, CFTR, TLR2

GO Terms for genes affiliated with Mycobacterium Abscessus

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16Gene Ontology
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Cellular components related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.1TNF, CFTR, TLR2
2external side of plasma membraneGO:0098978.9CLEC7A, TNF, TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:00275210.2CLEC7A, TLR2
2positive regulation of tumor necrosis factor productionGO:03276010.0TLR2, CLEC7A
3positive regulation of interleukin-18 productionGO:0327419.9TLR2, TNF
4positive regulation of chemokine productionGO:0327229.8TNF, TLR2
5negative regulation of growth of symbiont in hostGO:0441309.8TNF, TLR2
6regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.8SQSTM1, TNF
7positive regulation of NF-kappaB import into nucleusGO:0423469.8TNF, TLR2
8lipopolysaccharide-mediated signaling pathwayGO:0316639.8TLR2, TNF
9positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, TLR2
10defense response to Gram-positive bacteriumGO:0508309.7TNF, TLR2
11cellular response to molecule of fungal originGO:0712269.7SYK, CLEC7A
12leukocyte activation involved in immune responseGO:0023669.7CLEC7A, SYK
13positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432809.6NLRP3, TNF
14embryonic digestive tract developmentGO:0485669.6TNF, IL8
15positive regulation of interleukin-6 productionGO:0327559.5TNF, TLR2
16positive regulation of NF-kappaB transcription factor activityGO:0510929.5NLRP3, TNF, TLR2
17response to hypoxiaGO:0016669.4TLR2, TNF, SERPINA1
18response to cytokineGO:0340979.3SERPINA1, CFTR
19calcium-mediated signalingGO:0197229.2TNF, IL8
20neutrophil chemotaxisGO:0305939.2SYK, IL8
21positive regulation of cytokine secretionGO:0507159.1TLR2, TNF, SYK
22negative regulation of cell proliferationGO:0082859.0IL8, TNF, TLR2
23innate immune responseGO:0450878.9NLRP3, SYK, CLEC7A, TLR2
24inflammatory responseGO:0069548.7NLRP3, IL8, CLEC7A, TNF, TLR2

Molecular functions related to Mycobacterium Abscessus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signaling pattern recognition receptor activityGO:0083299.9CLEC7A, TLR2
2peptidoglycan bindingGO:0428349.7NLRP3, TLR2
3protease bindingGO:0020209.4SERPINA1, TNF
4protein bindingGO:0055156.3TLR2, CFTR, TNF, SERPINA1, IL8, SYK

Products for genes affiliated with Mycobacterium Abscessus

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Sources for Mycobacterium Abscessus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet