MCID: MYC013
MIFTS: 41

Mycobacterium Abscessus malady

Categories: Rare diseases

Aliases & Classifications for Mycobacterium Abscessus

Aliases & Descriptions for Mycobacterium Abscessus:

Name: Mycobacterium Abscessus 50
Mycobacterium Abscessus Infection 50
M. Abscessus 50

Classifications:



Summaries for Mycobacterium Abscessus

MalaCards based summary : Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to colobomatous microphthalmia and immunodeficiency 28, mycobacteriosis. An important gene associated with Mycobacterium Abscessus is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Azithromycin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Mycobacterium abscessus is a rapidly growing mycobacterium that is a common water contaminant. It was... more...

Related Diseases for Mycobacterium Abscessus

Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 colobomatous microphthalmia 11.0
2 immunodeficiency 28, mycobacteriosis 11.0
3 cystic fibrosis 10.5
4 mycobacterium chelonae 10.4
5 lung disease 10.3
6 nguyen syndrome 10.2 TLR1 TLR2
7 myeloid proliferations related to down syndrome 10.2 CXCL8 TLR2
8 inflammatory bowel disease 2 10.2 CFTR CLEC7A TLR2
9 myoclonic astatic epilepsy 10.1 CXCL8 NLRP3 TLR2
10 asymptomatic dengue 10.1 CLEC7A SYK
11 pneumonia 10.1
12 mycobacterium fortuitum 10.1
13 nystagmus, congenital motor, autosomal recessive 10.1 CFTR TLR2 TNF
14 autosomal dominant intermediate charcot-marie-tooth 10.1 CFTR TNF
15 endophthalmitis 10.1
16 otitis media 10.1
17 keratitis 10.1
18 endocarditis 10.1
19 parasitic ichthyosporea infectious disease 10.1 TLR1 TLR2 TNF
20 rickettsialpox 10.0 TLR1 TLR2 TNF
21 congenital hypothyroidism 10.0 CLEC7A TLR2 TNF
22 mansonelliasis 10.0 TLR1 TLR2 TNF
23 uterine adnexa cancer 10.0 TLR1 TLR2 TNF
24 bacteremia 10.0
25 tuberculosis 10.0
26 osteomyelitis 10.0
27 warthin tumor 10.0 NLRP3 TNF
28 conidiobolomycosis 10.0 CXCL8 TNF
29 atrial septal defect 6 10.0 TLR1 TLR2 TNF
30 ulcerative proctitis 10.0 CXCL8 TLR2 TNF
31 spotted fever 10.0 TLR2 TNF
32 inappropriate adh syndrome 10.0 CXCL8 TLR2 TNF
33 ovarian cystic teratoma 10.0 CXCL8 TLR2 TNF
34 senile reticular retinal degeneration 10.0 CXCL8 NLRP3 TNF
35 malignant histiocytosis 10.0 CXCL8 NLRP3 TNF
36 thymic neuroendocrine carcinoma 10.0 CXCL8 TNF
37 skin conditions 10.0 CXCL8 NLRP3 TNF
38 unilateral hypoactive labyrinth 10.0 CXCL8 TLR2 TNF
39 baritosis 10.0 CXCL8 NLRP3 TNF
40 mastitis 10.0
41 arthritis 10.0
42 peritonitis 10.0
43 lymphadenitis 10.0
44 asbestosis 10.0 CXCL8 TLR2 TNF
45 keratomalacia 10.0 CXCL8 TLR2 TNF
46 nephropathy with pretibial epidermolysis bullosa and deafness 10.0 CXCL8 TLR2 TNF
47 ectothrix infectious disease 10.0 CLEC7A CXCL8 TLR1 TLR2
48 pyelonephritis 10.0 CFTR CXCL8 TNF
49 sclerosing adenosis of breast 10.0 CXCL8 TLR2 TNF
50 pigmentation disease 10.0 CXCL8 TLR2 TNF

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to Mycobacterium Abscessus

Symptoms & Phenotypes for Mycobacterium Abscessus

MGI Mouse Phenotypes related to Mycobacterium Abscessus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 NLRP3 SQSTM1 SYK TLR1 TLR2 TNF
2 homeostasis/metabolism MP:0005376 9.96 NLRP3 SQSTM1 SYK TLR2 TNF CFTR
3 immune system MP:0005387 9.85 CFTR CLEC7A HMOX1 IFNGR2 NLRP3 SQSTM1
4 liver/biliary system MP:0005370 9.5 CFTR HMOX1 NLRP3 SQSTM1 SYK TLR2
5 respiratory system MP:0005388 9.1 CFTR CLEC7A HMOX1 SYK TLR2 TNF

Drugs & Therapeutics for Mycobacterium Abscessus

Drugs for Mycobacterium Abscessus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
2
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
3
Tigecycline Approved Phase 2 220620-09-7 5282044
4
Amikacin Approved, Vet_approved Phase 2 37517-28-5 37768
5 Anti-Bacterial Agents Phase 2
6 Anti-Infective Agents Phase 2
7 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Azithromycin in the Treatment of M. Avium Complex Lung Disease Completed NCT00599079 Phase 4
2 Tigecycline for Treatment of Rapidly Growing Mycobacteria Completed NCT00600600 Phase 2
3 Liposomal Amikacin for Inhalation (LAI) in the Treatment of Mycobacterium Abscessus Lung Disease Recruiting NCT03038178 Phase 2
4 Inhaled Amikacin Treatment for Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2
5 The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease Unknown status NCT02005094
6 The Incidence of Nontuberculous Mycobacterial Pulmonary Infection in Bilateral Bronchiectasis and Bronchiolitis Unknown status NCT01354912
7 PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis Recruiting NCT02419989
8 Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease Not yet recruiting NCT02832843

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

Anatomical Context for Mycobacterium Abscessus

MalaCards organs/tissues related to Mycobacterium Abscessus:

39
Lung, Skin, Testes, Breast, Colon, T Cells, Prostate

Publications for Mycobacterium Abscessus

Articles related to Mycobacterium Abscessus:

(show top 50) (show all 435)
id Title Authors Year
1
Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease. ( 28011608 )
2017
2
Multidrug-resistant Mycobacterium abscessus threatens patients with cystic fibrosis. ( 27956215 )
2017
3
Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense. ( 28011609 )
2017
4
Selection of Resistance to Clarithromycin in Mycobacterium abscessus Subspecies. ( 27799212 )
2017
5
Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. ( 28077517 )
2017
6
Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence. ( 27495169 )
2016
7
Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium abscessus pulmonary disease in outpatient settings: a case series. ( 27506679 )
2016
8
Mycobacterium abscessus as a Cause of Chronic Meningitis: A Rare Clinical Entity. ( 27079354 )
2016
9
Treatment of Mycobacterium abscessus Infection. ( 26890211 )
2016
10
Standardized interpretation of antibiotic susceptibility testing and resistance genotyping for Mycobacterium abscessus with regard to subspecies and erm41 sequevar. ( 27147307 )
2016
11
18 Cases of pulmonary Mycobacterium abscessus: Clinical difference depending on the presence or absence of Mycobacterium avium complex. ( 27430867 )
2016
12
Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. ( 27806130 )
2016
13
Pseudooutbreak of rapidly growing mycobacteria due to Mycobacterium abscessus subsp bolletii in a digestive and respiratory endoscopy unit caused by the same clone as that of a countrywide outbreak. ( 27524260 )
2016
14
Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591. ( 27999011 )
2016
15
Emended description of Mycobacterium abscessus, Mycobacterium abscessus subs. abscessus, Mycobacterium abscessus subsp. bolletii and designation of Mycobacterium abscessus subsp. massiliense comb. nov. ( 27499141 )
2016
16
Failure of the Amikacin, Cefoxitin, and Clarithromycin Combination Regimen for Treating Pulmonary Mycobacterium abscessus Infection. ( 27458221 )
2016
17
Pulmonary Mycobacterium abscessus Infection in a Patient with Triple A Syndrome. ( 27080471 )
2016
18
Management of Mycobacterium abscessus Infection After Medical Tourism in Cosmetic Surgery and a Review of Literature. ( 26835829 )
2016
19
Moxifloxacin's Limited Efficacy in the Hollow-Fiber Model of Mycobacterium abscessus Disease. ( 27067317 )
2016
20
Resazurin Microtiter Assay for Clarithromycin Susceptibility Testing of Clinical Isolates of Mycobacterium abscessus Group. ( 27169515 )
2016
21
Acquisition of Mycobacterium abscessus among ventilator-dependent patients in Taiwan chronic respiratory care facilities. ( 27064349 )
2016
22
Cystic teratoma mimicking recurrent pleural effusion, complicated by Mycobacterium abscessus infection. ( 27516884 )
2016
23
MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus. ( 27513974 )
2016
24
Disseminated Mycobacterium abscessus Complex Infection Manifesting as Multiple Areas of Lymphadenitis and Skin Abscess in the Preclinical Stage of Acute Lymphocytic Leukemia. ( 27374685 )
2016
25
Evaluation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Mycobacterium abscessus Subspecies According to Whole-Genome Sequencing. ( 27682129 )
2016
26
Bactericidal and intracellular activity of I^-lactams against Mycobacterium abscessus. ( 26929268 )
2016
27
Radiologic computed tomography features of Mycobacterium abscessus in cystic fibrosis. ( 27460837 )
2016
28
Mycobacterium abscessus Lung Infection: A Case Report. ( 27403004 )
2016
29
Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. ( 27439605 )
2016
30
Cutaneous Mycobacterium abscessus infection following hair transplant. ( 27663154 )
2016
31
Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-I^ Autoantibodies. ( 27419165 )
2016
32
Mycobacterium abscessus scleritis after a Baerveldt glaucoma implant. ( 27552708 )
2016
33
Biochemical Characterization of I^-Lactamases from Mycobacterium abscessus Complex and Genetic Environment of the I^-Lactamase-Encoding Gene. ( 27429159 )
2016
34
Mycobacterium abscessus complex bacteremia due to prostatitis after prostate biopsy. ( 27998503 )
2016
35
Erratum for Brown-Elliott et al., Utility of Sequencing the erm(41) Gene in Isolates of Mycobacterium abscessus subsp. abscessus with Low and Intermediate Clarithromycin MICs. ( 27016591 )
2016
36
Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications. ( 26884275 )
2016
37
MgtC as a Host-Induced Factor and Vaccine Candidate against Mycobacterium abscessus Infection. ( 27481243 )
2016
38
Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. ( 27690688 )
2016
39
GenoType NTM-DR for Identifying Mycobacterium abscessus Subspecies and Determining Molecular Resistance. ( 27030487 )
2016
40
Eradication of Mycobacterium abscessus Pulmonary Infection in a Child With Idiopathic Bronchiectasis. ( 27896296 )
2016
41
Allele-specific duplex polymerase chain reaction to differentiate Mycobacterium abscessus subspecies and to detect highly clarithromycin-resistant isolates. ( 27514964 )
2016
42
A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus. ( 27121350 )
2016
43
The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages. ( 27906132 )
2016
44
Successful antibiotic treatment of pulmonary disease caused by Mycobacterium abscessus subsp. abscessus with C-to-T mutation at position 19 in erm(41) gene: case report. ( 27188784 )
2016
45
A Novel Therapeutic Approach using Mesenchymal Stem Cells to Protect against Mycobacterium abscessus. ( 26946350 )
2016
46
Survival of Mycobacterium abscessus isolated from people with cystic fibrosis in artificially generated aerosols. ( 27660513 )
2016
47
Notes from the Field: Mycobacterium abscessus Infections Among Patients of a Pediatric Dentistry Practice - Georgia, 2015. ( 27054966 )
2016
48
Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection. ( 27637463 )
2016
49
Persistent Mycobacterium abscessus infection secondary to interferon-I^ autoantibodies. ( 27009440 )
2016
50
Tigecycline Is Highly Efficacious against Mycobacterium abscessus Pulmonary Disease. ( 26926649 )
2016

Variations for Mycobacterium Abscessus

Expression for Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for Mycobacterium Abscessus

Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 CLEC7A CXCL8 HMOX1 IFNGR2 NLRP3 SERPINA1
2
Show member pathways
13.2 CXCL8 HMOX1 IFNGR2 SQSTM1 SYK TNF
3
Show member pathways
12.65 CXCL8 IFNGR2 NLRP3 TLR2 TNF
4
Show member pathways
12.58 CXCL8 IFNGR2 SQSTM1 SYK TLR1 TLR2
5 12.39 HMOX1 SYK TLR1 TLR2 TNF
6
Show member pathways
12.2 CFTR CXCL8 TLR2 TNF
7
Show member pathways
12.11 CXCL8 IFNGR2 TNF
8
Show member pathways
12.11 CFTR CLEC7A CXCL8 HMOX1 NLRP3 SYK
9 12.04 IFNGR2 TLR1 TLR2 TNF
10
Show member pathways
12.04 CXCL8 SQSTM1 TLR1 TLR2 TNF
11 11.97 HMOX1 SERPINA1 SQSTM1
12 11.94 HMOX1 SQSTM1 TNF
13 11.92 IFNGR2 SQSTM1 SYK TNF
14 11.89 CLEC7A IFNGR2 SYK TLR1 TLR2 TNF
15 11.84 CXCL8 HMOX1 TNF
16
Show member pathways
11.79 IFNGR2 TLR1 TLR2 TNF
17 11.76 CXCL8 TLR2 TNF
18 11.75 CXCL8 SYK TNF
19 11.72 CXCL8 TLR2 TNF
20 11.69 CLEC7A TLR1 TLR2
21
Show member pathways
11.65 CFTR CXCL8 IFNGR2 TLR1 TLR2 TNF
22 11.63 CXCL8 NLRP3 TNF
23 11.46 CXCL8 TLR2 TNF
24 11.42 CXCL8 HMOX1 SERPINA1 TNF
25 11.4 CXCL8 TLR2 TNF
26 11.05 NLRP3 TLR1 TLR2
27 11.01 CXCL8 TNF
28 10.86 CXCL8 HMOX1 TNF

GO Terms for Mycobacterium Abscessus

Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.91 CXCL8 HMOX1 SQSTM1 SYK
2 innate immune response GO:0045087 9.85 CLEC7A NLRP3 SYK TLR1 TLR2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 NLRP3 TLR2 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.74 CXCL8 NLRP3 TNF
5 regulation of sequence-specific DNA binding transcription factor activity GO:0051090 9.62 HMOX1 SYK
6 positive regulation of macroautophagy GO:0016239 9.61 HMOX1 SQSTM1
7 positive regulation of interleukin-8 production GO:0032757 9.6 TLR2 TNF
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.59 TLR2 TNF
9 embryonic digestive tract development GO:0048566 9.58 CXCL8 TNF
10 positive regulation of chemokine production GO:0032722 9.56 TLR2 TNF
11 defense response GO:0006952 9.56 CXCL8 NLRP3 TLR1 TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.55 SQSTM1 TNF
13 cell activation GO:0001775 9.54 TLR1 TLR2
14 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.52 SQSTM1 TNF
15 response to molecule of bacterial origin GO:0002237 9.51 CXCL8 TLR2
16 regulation of cytokine secretion GO:0050707 9.49 TLR1 TLR2
17 positive regulation of chemokine biosynthetic process GO:0045080 9.48 HMOX1 TNF
18 leukocyte activation involved in immune response GO:0002366 9.43 CLEC7A SYK
19 immune system process GO:0002376 9.43 CLEC7A NLRP3 SQSTM1 SYK TLR1 TLR2
20 cellular response to molecule of fungal origin GO:0071226 9.4 CLEC7A SYK
21 cellular response to triacyl bacterial lipopeptide GO:0071727 9.37 TLR1 TLR2
22 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.32 TLR1 TLR2
23 inflammatory response GO:0006954 9.17 CLEC7A CXCL8 NLRP3 SYK TLR1 TLR2
24 detection of triacyl bacterial lipopeptide GO:0042495 9.16 TLR1 TLR2

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.26 NLRP3 TLR2
2 lipopeptide binding GO:0071723 9.16 TLR1 TLR2
3 signaling pattern recognition receptor activity GO:0008329 8.96 CLEC7A TLR2
4 Toll-like receptor binding GO:0035325 8.62 SYK TLR2

Sources for Mycobacterium Abscessus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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