MCID: MYC013
MIFTS: 45

Mycobacterium Abscessus

Categories: Rare diseases

Aliases & Classifications for Mycobacterium Abscessus

MalaCards integrated aliases for Mycobacterium Abscessus:

Name: Mycobacterium Abscessus 49
Mycobacterium Abscessus Infection 49
M. Abscessus 49

Classifications:



Summaries for Mycobacterium Abscessus

MalaCards based summary : Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to mycobacterium chelonae and mycobacterium kansasii. An important gene associated with Mycobacterium Abscessus is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Azithromycin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Mycobacterium abscessus complex (MABSC) is a group of rapidly growing, multidrug-resistant... more...

Related Diseases for Mycobacterium Abscessus

Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 mycobacterium chelonae 31.3 CXCL8 TLR2
2 mycobacterium kansasii 30.2 CXCL8 NLRP3 TLR2
3 mycobacterium tuberculosis 1 30.1 TLR1 TLR2 TNF
4 nontuberculous mycobacterial lung disease 30.1 CFTR TLR2 TNF
5 endocarditis 30.0 CXCL8 TLR2 TNF
6 otitis media 30.0 CXCL8 TLR2 TNF
7 pneumonia 30.0 CXCL8 TLR2 TNF
8 peritonitis 29.9 CXCL8 TLR2 TNF
9 lung disease 29.5 CFTR CXCL8 SERPINA1 TNF
10 meningitis 29.5 CXCL8 NLRP3 TLR2 TNF
11 bronchiolitis 29.4 CXCL8 TLR1 TNF
12 bronchiectasis 29.3 CFTR CXCL8 SERPINA1 TLR2
13 macs syndrome 11.2
14 cystic fibrosis 10.6
15 fibrosis of extraocular muscles, congenital, 1 10.6
16 neurosyphilis 10.4 TLR1 TLR2
17 subcutaneous mycosis 10.3 CLEC7A SYK
18 mycobacterium fortuitum 10.3
19 aspergillosis 10.2 CFTR CLEC7A TLR2
20 osteomyelitis 10.2
21 trench fever 10.2 TLR2 TNF
22 endophthalmitis 10.2
23 keratitis, hereditary 10.2
24 common wart 10.1 CLEC7A CXCL8
25 vulvar vestibulitis syndrome 10.1 NLRP3 TNF
26 autoimmune pancreatitis 10.1 CFTR TNF
27 mastitis 10.1
28 lymphadenitis 10.1
29 bacteremia 2 10.1
30 periodic fever, familial, autosomal dominant 10.1 NLRP3 TNF
31 arthritis 10.1
32 penicilliosis 10.0 TLR1 TLR2 TNF
33 q fever 10.0 TLR1 TLR2 TNF
34 melioidosis 10.0 TLR1 TLR2 TNF
35 lyme disease 10.0 TLR1 TLR2 TNF
36 filariasis 10.0 TLR1 TLR2 TNF
37 primary systemic mycosis 10.0 CLEC7A TLR2 TNF
38 tungiasis 10.0 CXCL8 TNF
39 streptococcal toxic-shock syndrome 10.0 CXCL8 TNF
40 scleritis 10.0
41 rheumatoid arthritis 10.0
42 keratopathy 10.0
43 prostatitis 10.0
44 cervicitis 10.0
45 trichuriasis 9.9 CXCL8 TNF
46 alveolar echinococcosis 9.9 TLR2 TNF
47 sebaceous gland disease 9.9 CXCL8 TLR2
48 clonorchiasis 9.9 CXCL8 TNF
49 tuberculous meningitis 9.9 CXCL8 TLR2 TNF
50 middle ear disease 9.9 CXCL8 TLR2 TNF

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to Mycobacterium Abscessus

Symptoms & Phenotypes for Mycobacterium Abscessus

MGI Mouse Phenotypes related to Mycobacterium Abscessus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 SQSTM1 SYK CFTR TLR1 TLR2 CLEC7A
2 homeostasis/metabolism MP:0005376 9.96 NLRP3 SQSTM1 SYK CFTR CLEC7A TLR2
3 immune system MP:0005387 9.85 SQSTM1 SYK CFTR TLR1 TLR2 CLEC7A
4 liver/biliary system MP:0005370 9.5 NLRP3 SQSTM1 SYK CFTR TLR2 HMOX1
5 respiratory system MP:0005388 9.1 SYK CFTR CLEC7A TLR2 HMOX1 TNF

Drugs & Therapeutics for Mycobacterium Abscessus

Drugs for Mycobacterium Abscessus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
2
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
3
Tigecycline Approved Phase 2 220620-09-7 5282044
4
Nitric Oxide Approved Phase 2 10102-43-9 145068
5
Amikacin Approved, Investigational, Vet_approved Phase 2 37517-28-5 37768
6 Anti-Bacterial Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Respiratory System Agents Phase 2
9 Neurotransmitter Agents Phase 2
10 Vasodilator Agents Phase 2
11 Peripheral Nervous System Agents Phase 2
12 Anti-Asthmatic Agents Phase 2
13 Endothelium-Dependent Relaxing Factors Phase 2
14 Protective Agents Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Antioxidants Phase 2
17 Autonomic Agents Phase 2
18 Bronchodilator Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Azithromycin in the Treatment of M. Avium Complex Lung Disease Completed NCT00599079 Phase 4 Azithromycin
2 Tigecycline for Treatment of Rapidly Growing Mycobacteria Completed NCT00600600 Phase 2 Tigecycline
3 Liposomal Amikacin for Inhalation (LAI) in the Treatment of Mycobacterium Abscessus Lung Disease Recruiting NCT03038178 Phase 2 LAI plus multi-drug regimen
4 Inhaled Nitric Oxide for Patients With MABSC Recruiting NCT03208764 Phase 2 Nitric Oxide
5 Inhaled Amikacin Treatment for Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2 Amikacin
6 The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease Unknown status NCT02005094
7 The Incidence of Nontuberculous Mycobacterial Pulmonary Infection in Bilateral Bronchiectasis and Bronchiolitis Unknown status NCT01354912
8 Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease Recruiting NCT02832843
9 The Italian REgistry of Pulmonary Non-tuberculous mycobactEria Recruiting NCT03339063

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

Anatomical Context for Mycobacterium Abscessus

MalaCards organs/tissues related to Mycobacterium Abscessus:

38
Lung, Skin, Testes, Colon, T Cells, Prostate, Neutrophil

Publications for Mycobacterium Abscessus

Articles related to Mycobacterium Abscessus:

(show top 50) (show all 481)
# Title Authors Year
1
<i>Mycobacterium abscessus</i> Complex Infections: A Retrospective Cohort Study. ( 29450214 )
2018
2
<i>Mycobacterium abscessus</i> Smooth And Rough Morpohotypes Form Antimicrobial-Tolerant Biofilm Phenotypes But Are Killed by Acetic Acid. ( 29311080 )
2018
3
In vitro activity of tedizolid against the Mycobacterium abscessus complex. ( 29217419 )
2018
4
Identification of genes required for<i>Mycobacterium abscessus</i>growth in vivo with a prominent role of the ESX-4 locus. ( 29343644 )
2018
5
Mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. ( 28988958 )
2018
6
Complete Genome Sequence of a Type Strain of<i>Mycobacterium abscessus</i>subsp.<i>bolletii</i>, a Member of the<i>Mycobacterium abscessus</i>Complex. ( 29437099 )
2018
7
Mycobacterium abscessus infections in lung transplant recipients: 15-year experience from a single institution. ( 29359872 )
2018
8
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for rapid identification of<i>Mycobacterium abscessus</i>. ( 29386727 )
2018
9
A Successful Aggressive Surgical and Medical approach to Pulmonary Artery Obstruction due to Mycobacterium abscessus Infection post Lung Transplantation. ( 29359876 )
2018
10
In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice. ( 29421865 )
2018
11
Inhaled Granulocyte-Macrophage Colony Stimulating Factor for<b> <i>Mycobacterium Abscessus</i> </b>in Cystic Fibrosis. ( 29419443 )
2018
12
Establishment and validation of<i>Galleria mellonella</i>as a novel model organism to study<i>Mycobacterium abscessus</i>infection, pathogenesis and treatment. ( 29437630 )
2018
13
Association between sequevar and antibiotic treatment outcome in patients with Mycobacterium abscessus complex infections in Japan. ( 29227218 )
2018
14
galK-based suicide vector mediated allelic exchange in Mycobacterium abscessus. ( 28933689 )
2017
15
Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease. ( 28011608 )
2017
16
<i>Mycobacterium abscessus</i> disease in lung transplant recipients: Diagnosis and management. ( 29276785 )
2017
17
Genomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazil. ( 28884021 )
2017
18
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish. ( 28807917 )
2017
19
<i>Aspergillus fumigatus</i> pre-exposure worsens pathology and improves control of<i>Mycobacterium abscessus</i>pulmonary infection in mice. ( 29263106 )
2017
20
Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus. ( 29193368 )
2017
21
Systematic review and meta-analyses of the effect of chemotherapy on pulmonary Mycobacterium abscessus outcomes and disease recurrence. ( 28807911 )
2017
22
Multi-Drug Resistant Surgical Site Infection Due to Mycobacterium abscessus Complex. ( 28934511 )
2017
23
Pleurisy Caused by Mycobacterium abscessus in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature. ( 29269658 )
2017
24
Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan. ( 29059250 )
2017
25
Detection of Mycobacterium chelonae, Mycobacterium abscessus Group, and Mycobacterium fortuitum Complex by a Multiplex Real-Time PCR Directly from Clinical Samples Using the BD MAX System. ( 28190461 )
2017
26
Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense. ( 28011609 )
2017
27
Antibiotic resistance in<i>Mycobacterium Abscessus</i>and<i>Mycobacterium Fortuitum</i>isolates from Malaysian patients. ( 29171453 )
2017
28
Selection of Resistance to Clarithromycin in Mycobacterium abscessus Subspecies. ( 27799212 )
2017
29
Pediatric Dental Clinic-Associated Outbreak of Mycobacterium abscessus Infection. ( 28903524 )
2017
30
Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro. ( 28923867 )
2017
31
Multidrug-resistant Mycobacterium abscessus threatens patients with cystic fibrosis. ( 27956215 )
2017
32
Trehalose Polyphleates, External Cell Wall Lipids in Mycobacterium abscessus, Are Associated with the Formation of Clumps with Cording Morphology, Which Have Been Associated with Virulence. ( 28790995 )
2017
33
Mycobacterium abscessus glycopeptidolipids inhibit macrophage apoptosis and bacterial spreading by targeting mitochondrial cyclophilin D. ( 28837151 )
2017
34
Mycobacterium abscessus glossitis. ( 28948933 )
2017
35
Activity of rifabutin and hemi-synthetic derivatives against Mycobacterium abscessus. ( 29205119 )
2017
36
Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins. ( 28760902 )
2017
37
Anti-interferon-I^ autoantibody-associated disseminated Mycobacterium abscessus infection mimicking parotid cancer with multiple metastases: A case report. ( 28953638 )
2017
38
Granulomatous Lobular Mastitis Associated with Mycobacterium abscessus in South China: A Case Report and Review of the Literature. ( 28286681 )
2017
39
Antagonism between front line antibiotics clarithromycin and amikacin used for the treatment of Mycobacterium abscessus infections is mediated by the whiB7 gene. ( 28874379 )
2017
40
Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. ( 28903728 )
2017
41
Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. ( 28077517 )
2017
42
Mycobacterium abscessus WhiB7 regulates a species -specific repertoire of genes to confer extreme antibiotic resistance. ( 28874378 )
2017
43
Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport. ( 28920054 )
2017
44
Peritoneal dialysis-associated catheter infection caused by Mycobacterium abscessus in an elderly patient who was successfully treated with catheter removal. ( 28795380 )
2017
45
A Patient-Based Analysis of the Geographic Distribution of Mycobacterium avium complex, Mycobacterium abscessus, and Mycobacterium kansasii Infections in the United States. ( 28390637 )
2017
46
Genetic correlates of clarithromycin susceptibility among isolates of the Mycobacterium abscessus group and the potential clinical applicability of a PCR-based analysis of erm(41). ( 29272470 )
2017
47
Reinstating Mycobacterium massiliense and Mycobacterium bolletii as species of the Mycobacterium abscessus complex. ( 28820087 )
2017
48
Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease. ( 29329759 )
2017
49
Predominance of clarithromycin-susceptible Mycobacterium massiliense subspecies: Characterization of the Mycobacterium abscessus complex at a tertiary acute care hospital. ( 28874233 )
2017
50
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017

Variations for Mycobacterium Abscessus

Expression for Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for Mycobacterium Abscessus

Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CLEC7A CXCL8 HMOX1 IFNGR2 NLRP3 SERPINA1
2
Show member pathways
13.22 CXCL8 HMOX1 IFNGR2 SQSTM1 SYK TNF
3
Show member pathways
12.66 CXCL8 IFNGR2 NLRP3 TLR2 TNF
4
Show member pathways
12.44 CXCL8 SYK TLR2 TNF
5 12.41 HMOX1 SYK TLR1 TLR2 TNF
6
Show member pathways
12.37 CXCL8 IFNGR2 TLR1 TLR2 TNF
7
Show member pathways
12.21 CFTR CXCL8 TLR2 TNF
8
Show member pathways
12.12 CXCL8 IFNGR2 TNF
9
Show member pathways
12.1 CFTR CLEC7A CXCL8 HMOX1 NLRP3 SYK
10
Show member pathways
12.08 IFNGR2 NLRP3 SQSTM1 TNF
11 12.04 IFNGR2 TLR1 TLR2 TNF
12
Show member pathways
12 CXCL8 SQSTM1 TLR1 TLR2 TNF
13 11.98 HMOX1 SERPINA1 SQSTM1
14 11.95 HMOX1 SQSTM1 TNF
15 11.92 IFNGR2 SQSTM1 SYK TNF
16 11.89 CLEC7A IFNGR2 SYK TLR1 TLR2 TNF
17 11.86 CXCL8 HMOX1 TNF
18 11.77 CXCL8 TLR2 TNF
19 11.76 CXCL8 SYK TNF
20
Show member pathways
11.75 IFNGR2 TLR1 TLR2 TNF
21 11.73 CXCL8 TLR2 TNF
22 11.7 CLEC7A TLR1 TLR2
23
Show member pathways
11.65 CFTR CXCL8 IFNGR2 TLR1 TLR2 TNF
24 11.64 CXCL8 NLRP3 TNF
25 11.47 CXCL8 TLR2 TNF
26 11.41 CXCL8 TLR2 TNF
27 11.36 CXCL8 HMOX1 SERPINA1 TNF
28 11.03 NLRP3 TLR1 TLR2
29 11.02 CXCL8 TNF
30 10.86 CXCL8 HMOX1 TNF

GO Terms for Mycobacterium Abscessus

Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.43 CFTR HMOX1 IFNGR2 NLRP3 SERPINA1 SQSTM1
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.91 CXCL8 HMOX1 SQSTM1 SYK
2 innate immune response GO:0045087 9.83 CLEC7A NLRP3 SYK TLR1 TLR2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 NLRP3 TLR2 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.74 CXCL8 NLRP3 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.65 NLRP3 TLR2 TNF
6 regulation of DNA binding transcription factor activity GO:0051090 9.62 HMOX1 SYK
7 positive regulation of interleukin-8 production GO:0032757 9.61 TLR2 TNF
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.6 TLR2 TNF
9 positive regulation of chemokine production GO:0032722 9.58 TLR2 TNF
10 embryonic digestive tract development GO:0048566 9.58 CXCL8 TNF
11 cell activation GO:0001775 9.56 TLR1 TLR2
12 defense response GO:0006952 9.56 CXCL8 NLRP3 TLR1 TNF
13 negative regulation of growth of symbiont in host GO:0044130 9.55 SQSTM1 TNF
14 positive regulation of interleukin-8 secretion GO:2000484 9.54 TLR1 TLR2
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.52 SQSTM1 TNF
16 response to molecule of bacterial origin GO:0002237 9.51 CXCL8 TLR2
17 regulation of cytokine secretion GO:0050707 9.49 TLR1 TLR2
18 positive regulation of chemokine biosynthetic process GO:0045080 9.46 HMOX1 TNF
19 immune system process GO:0002376 9.43 CLEC7A NLRP3 SQSTM1 SYK TLR1 TLR2
20 cytokine secretion involved in immune response GO:0002374 9.4 NLRP3 TLR2
21 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.37 TLR1 TLR2
22 cellular response to triacyl bacterial lipopeptide GO:0071727 9.32 TLR1 TLR2
23 inflammatory response GO:0006954 9.17 CLEC7A CXCL8 NLRP3 SYK TLR1 TLR2
24 detection of triacyl bacterial lipopeptide GO:0042495 9.16 TLR1 TLR2

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.26 NLRP3 TLR2
2 lipopeptide binding GO:0071723 9.16 TLR1 TLR2
3 signaling pattern recognition receptor activity GO:0008329 8.96 CLEC7A TLR2
4 Toll-like receptor binding GO:0035325 8.62 SYK TLR2

Sources for Mycobacterium Abscessus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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