MCID: MYC013
MIFTS: 41

Mycobacterium Abscessus

Categories: Rare diseases

Aliases & Classifications for Mycobacterium Abscessus

MalaCards integrated aliases for Mycobacterium Abscessus:

Name: Mycobacterium Abscessus 50
Mycobacterium Abscessus Infection 50
M. Abscessus 50

Classifications:



Summaries for Mycobacterium Abscessus

MalaCards based summary : Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to mycobacterium kansasii and colobomatous microphthalmia. An important gene associated with Mycobacterium Abscessus is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Azithromycin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Mycobacterium abscessus complex (MABSC) is a group of rapidly growing, multidrug-resistant... more...

Related Diseases for Mycobacterium Abscessus

Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
id Related Disease Score Top Affiliating Genes
1 mycobacterium kansasii 23.5 CFTR CLEC7A CXCL8 HMOX1 IFNGR2 MSRA
2 colobomatous microphthalmia 11.0
3 immunodeficiency 28, mycobacteriosis 11.0
4 neutrophil-specific granule deficiency 10.6 TLR1 TLR2
5 intestinal botulism 10.5 CLEC7A SYK
6 mycobacterium malmoense 10.5 CXCL8 TLR2
7 cystic fibrosis 10.5
8 mycobacterium chelonae 10.4
9 deafness, autosomal recessive 62 10.4 CFTR CLEC7A TLR2
10 rickettsialpox 10.3 TLR2 TNF
11 lung disease 10.3
12 mycobacterium xenopi 10.3 CXCL8 NLRP3 TLR2
13 total internal ophthalmoplegia 10.3 CLEC7A CXCL8
14 walker dyson syndrome 10.3 NLRP3 TNF
15 autoimmune retinopathy 10.3 CFTR TNF
16 antigen-peptide-transporter 2 deficiency 10.3 TLR2 TNF
17 multiple sclerosis 5 10.2 NLRP3 TNF
18 not otherwise specified 3-mga-uria type 10.2 CFTR TLR2 TNF
19 mycobacterium fortuitum 10.1
20 pneumonia 10.1
21 trichosporonosis 10.1 TLR1 TLR2 TNF
22 bartonellosis 10.1 TLR1 TLR2 TNF
23 melioidosis 10.1 TLR1 TLR2 TNF
24 uterine adnexa cancer 10.1 TLR1 TLR2 TNF
25 alkhurma hemorrhagic fever 10.1 CLEC7A TLR2 TNF
26 gastric ulcer 10.1 TLR1 TLR2 TNF
27 otitis media 10.1
28 keratitis 10.1
29 osteomyelitis 10.1
30 endocarditis 10.1
31 endophthalmitis 10.1
32 basidiobolomycosis 10.1 CXCL8 TNF
33 spirillary rat-bite fever 10.1 CXCL8 TNF
34 bacteremia 10.0
35 mastitis 10.0
36 lymphadenitis 10.0
37 tuberculosis 10.0
38 peritonitis 10.0
39 aspartylglucosaminuria 10.0 TLR1 TLR2 TNF
40 tarsal tunnel syndrome 10.0 CXCL8 TNF
41 arthritis 10.0
42 plantar wart 10.0 CXCL8 TNF
43 tumefactive multiple sclerosis 9.9 CXCL8 TLR2 TNF
44 testicular infarct 9.9 CXCL8 TLR2 TNF
45 amyotrophic lateral sclerosis type 10 9.9 CXCL8 TNF
46 palmoplantar keratosis 9.9 CXCL8 TLR2 TNF
47 senile reticular retinal degeneration 9.9 CXCL8 NLRP3 TNF
48 atrophy of prostate 9.9 CXCL8 TLR2 TNF
49 lip cancer 9.9 CXCL8 NLRP3 TNF
50 sheehan syndrome 9.9 CXCL8 TLR2 TNF

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to Mycobacterium Abscessus

Symptoms & Phenotypes for Mycobacterium Abscessus

MGI Mouse Phenotypes related to Mycobacterium Abscessus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 HMOX1 TNF IFNGR2 NLRP3 SQSTM1 SYK
2 homeostasis/metabolism MP:0005376 9.96 CLEC7A TLR2 HMOX1 TNF IFNGR2 MSRA
3 immune system MP:0005387 9.85 CLEC7A HMOX1 TNF IFNGR2 NLRP3 SQSTM1
4 liver/biliary system MP:0005370 9.5 TLR2 HMOX1 TNF NLRP3 SQSTM1 SYK
5 respiratory system MP:0005388 9.1 CLEC7A TLR2 HMOX1 TNF SYK CFTR

Drugs & Therapeutics for Mycobacterium Abscessus

Drugs for Mycobacterium Abscessus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
2
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
3
Tigecycline Approved Phase 2 220620-09-7 5282044
4
Amikacin Approved, Vet_approved Phase 2 37517-28-5 37768
5
Nitric Oxide Approved Phase 2 10102-43-9 145068
6 Anti-Bacterial Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Antibiotics, Antitubercular Phase 2
9 Anti-Asthmatic Agents Phase 2
10 Antioxidants Phase 2
11 Autonomic Agents Phase 2
12 Bronchodilator Agents Phase 2
13 Endothelium-Dependent Relaxing Factors Phase 2
14 Neurotransmitter Agents Phase 2
15 Peripheral Nervous System Agents Phase 2
16 Protective Agents Phase 2
17 Respiratory System Agents Phase 2
18 Vasodilator Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Azithromycin in the Treatment of M. Avium Complex Lung Disease Completed NCT00599079 Phase 4 Azithromycin
2 Tigecycline for Treatment of Rapidly Growing Mycobacteria Completed NCT00600600 Phase 2 Tigecycline
3 Liposomal Amikacin for Inhalation (LAI) in the Treatment of Mycobacterium Abscessus Lung Disease Recruiting NCT03038178 Phase 2 LAI plus multi-drug regimen
4 Inhaled Nitric Oxide for Cystic Fibrosis Patients With MABSC Recruiting NCT03208764 Phase 2 Nitric Oxide
5 Inhaled Amikacin Treatment for Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2 Amikacin
6 The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease Unknown status NCT02005094
7 The Incidence of Nontuberculous Mycobacterial Pulmonary Infection in Bilateral Bronchiectasis and Bronchiolitis Unknown status NCT01354912
8 PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis Recruiting NCT02419989
9 Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease Not yet recruiting NCT02832843

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

Anatomical Context for Mycobacterium Abscessus

MalaCards organs/tissues related to Mycobacterium Abscessus:

39
Lung, Skin, Testes, Breast, Colon, T Cells, Prostate

Publications for Mycobacterium Abscessus

Articles related to Mycobacterium Abscessus:

(show top 50) (show all 458)
id Title Authors Year
1
Antagonism between front line antibiotics clarithromycin and amikacin used for the treatment of Mycobacterium abscessus infections is mediated by the whiB7 gene. ( 28874379 )
2017
2
Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport. ( 28920054 )
2017
3
Multidrug-resistant Mycobacterium abscessus threatens patients with cystic fibrosis. ( 27956215 )
2017
4
Selection of Resistance to Clarithromycin in Mycobacterium abscessus Subspecies. ( 27799212 )
2017
5
Detection of Mycobacterium chelonae, Mycobacterium abscessus Group, and Mycobacterium fortuitum Complex by a Multiplex Real-Time PCR Directly from Clinical Samples Using the BD MAX System. ( 28190461 )
2017
6
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
7
Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease. ( 28011608 )
2017
8
Mycobacterium abscessus glycopeptidolipids inhibit macrophage apoptosis and bacterial spreading by targeting mitochondrial cyclophilin D. ( 28837151 )
2017
9
Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. ( 28077517 )
2017
10
Trehalose Polyphleates, External Cell Wall Lipids in Mycobacterium abscessus, Are Associated with the Formation of Clumps with Cording Morphology, Which Have Been Associated with Virulence. ( 28790995 )
2017
11
Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins. ( 28760902 )
2017
12
Predominance of clarithromycin-susceptible Mycobacterium massiliense subspecies: Characterization of the Mycobacterium abscessus complex at a tertiary acute care hospital. ( 28874233 )
2017
13
Multi-Drug Resistant Surgical Site Infection Due to Mycobacterium abscessus Complex. ( 28934511 )
2017
14
Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense. ( 28011609 )
2017
15
Genomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazil. ( 28884021 )
2017
16
Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. ( 28903728 )
2017
17
Pediatric Dental Clinic-Associated Outbreak of Mycobacterium abscessus Infection. ( 28903524 )
2017
18
Mycobacterium abscessus glossitis. ( 28948933 )
2017
19
Anti-interferon-I^ autoantibody-associated disseminated Mycobacterium abscessus infection mimicking parotid cancer with multiple metastases: A case report. ( 28953638 )
2017
20
galK-based suicide vector mediated allelic exchange in Mycobacterium abscessus. ( 28933689 )
2017
21
Reinstating Mycobacterium massiliense and Mycobacterium bolletii as species of the Mycobacterium abscessus complex. ( 28820087 )
2017
22
Systematic review and meta-analyses of the effect of chemotherapy on pulmonary Mycobacterium abscessus outcomes and disease recurrence. ( 28807911 )
2017
23
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish. ( 28807917 )
2017
24
Granulomatous Lobular Mastitis Associated with Mycobacterium abscessus in South China: A Case Report and Review of the Literature. ( 28286681 )
2017
25
Mycobacterium abscessus WhiB7 regulates a species -specific repertoire of genes to confer extreme antibiotic resistance. ( 28874378 )
2017
26
Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro. ( 28923867 )
2017
27
Peritoneal dialysis-associated catheter infection caused by Mycobacterium abscessus in an elderly patient who was successfully treated with catheter removal. ( 28795380 )
2017
28
A Patient-Based Analysis of the Geographic Distribution of Mycobacterium avium complex, Mycobacterium abscessus, and Mycobacterium kansasii Infections in the United States. ( 28390637 )
2017
29
Notes from the Field: Mycobacterium abscessus Infections Among Patients of a Pediatric Dentistry Practice - Georgia, 2015. ( 27054966 )
2016
30
Failure of the Amikacin, Cefoxitin, and Clarithromycin Combination Regimen for Treating Pulmonary Mycobacterium abscessus Infection. ( 27458221 )
2016
31
Radiologic computed tomography features of Mycobacterium abscessus in cystic fibrosis. ( 27460837 )
2016
32
Mycobacterium abscessus scleritis after a Baerveldt glaucoma implant. ( 27552708 )
2016
33
Pseudooutbreak of rapidly growing mycobacteria due to Mycobacterium abscessus subsp bolletii in a digestive and respiratory endoscopy unit caused by the same clone as that of a countrywide outbreak. ( 27524260 )
2016
34
MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus. ( 27513974 )
2016
35
Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications. ( 26884275 )
2016
36
Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. ( 27806130 )
2016
37
Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium abscessus pulmonary disease in outpatient settings: a case series. ( 27506679 )
2016
38
Mycobacterium abscessus Infection After Facial Injection With Autologous Fat: A Case Report. ( 27220017 )
2016
39
Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence. ( 27495169 )
2016
40
Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. ( 27690688 )
2016
41
Treatment of Mycobacterium abscessus Infection. ( 26890211 )
2016
42
Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. ( 27439605 )
2016
43
18 Cases of pulmonary Mycobacterium abscessus: Clinical difference depending on the presence or absence of Mycobacterium avium complex. ( 27430867 )
2016
44
Management of Mycobacterium abscessus Infection After Medical Tourism in Cosmetic Surgery and a Review of Literature. ( 26835829 )
2016
45
Prevalence and Antimicrobial Susceptibility of Mycobacterium abscessus in a General Hospital, China. ( 27003165 )
2016
46
Eradication of Mycobacterium abscessus Pulmonary Infection in a Child With Idiopathic Bronchiectasis. ( 27896296 )
2016
47
Persistent Mycobacterium abscessus infection secondary to interferon-I^ autoantibodies. ( 27009440 )
2016
48
Cutaneous Mycobacterium abscessus infection following hair transplant. ( 27663154 )
2016
49
Tigecycline Is Highly Efficacious against Mycobacterium abscessus Pulmonary Disease. ( 26926649 )
2016
50
Moxifloxacin's Limited Efficacy in the Hollow-Fiber Model of Mycobacterium abscessus Disease. ( 27067317 )
2016

Variations for Mycobacterium Abscessus

Expression for Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for Mycobacterium Abscessus

Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CLEC7A CXCL8 HMOX1 IFNGR2 NLRP3 SERPINA1
2
Show member pathways
13.2 CXCL8 HMOX1 IFNGR2 SQSTM1 SYK TNF
3
Show member pathways
12.64 CXCL8 IFNGR2 NLRP3 TLR2 TNF
4
Show member pathways
12.58 CXCL8 IFNGR2 SQSTM1 SYK TLR1 TLR2
5 12.37 HMOX1 SYK TLR1 TLR2 TNF
6
Show member pathways
12.19 CFTR CXCL8 TLR2 TNF
7
Show member pathways
12.11 CFTR CLEC7A CXCL8 HMOX1 NLRP3 SYK
8
Show member pathways
12.1 CXCL8 IFNGR2 TNF
9 12.03 IFNGR2 TLR1 TLR2 TNF
10 11.96 HMOX1 SERPINA1 SQSTM1
11 11.94 HMOX1 SQSTM1 TNF
12 11.9 IFNGR2 SQSTM1 SYK TNF
13 11.89 CLEC7A IFNGR2 SYK TLR1 TLR2 TNF
14 11.84 CXCL8 HMOX1 TNF
15 11.76 CXCL8 TLR2 TNF
16
Show member pathways
11.76 IFNGR2 TLR1 TLR2 TNF
17 11.75 CXCL8 SYK TNF
18 11.71 CXCL8 TLR2 TNF
19 11.68 CLEC7A TLR1 TLR2
20
Show member pathways
11.65 CFTR CXCL8 IFNGR2 TLR1 TLR2 TNF
21 11.62 CXCL8 NLRP3 TNF
22 11.45 CXCL8 TLR2 TNF
23 11.42 CXCL8 HMOX1 SERPINA1 TNF
24 11.39 CXCL8 TLR2 TNF
25 11.03 NLRP3 TLR1 TLR2
26 11.01 CXCL8 TNF
27 10.82 CXCL8 HMOX1 TNF

GO Terms for Mycobacterium Abscessus

Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.35 HMOX1 IFNGR2 NLRP3 SERPINA1 SQSTM1
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.88 CXCL8 HMOX1 SQSTM1 SYK
2 innate immune response GO:0045087 9.8 CLEC7A NLRP3 SYK TLR1 TLR2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.74 NLRP3 TLR2 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.73 CXCL8 NLRP3 TNF
5 regulation of sequence-specific DNA binding transcription factor activity GO:0051090 9.6 HMOX1 SYK
6 positive regulation of interleukin-8 production GO:0032757 9.59 TLR2 TNF
7 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 TLR2 TNF
8 defense response GO:0006952 9.56 CXCL8 NLRP3 TLR1 TNF
9 embryonic digestive tract development GO:0048566 9.55 CXCL8 TNF
10 positive regulation of chemokine production GO:0032722 9.54 TLR2 TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.52 SQSTM1 TNF
12 cell activation GO:0001775 9.51 TLR1 TLR2
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.49 SQSTM1 TNF
14 response to molecule of bacterial origin GO:0002237 9.48 CXCL8 TLR2
15 regulation of cytokine secretion GO:0050707 9.46 TLR1 TLR2
16 positive regulation of chemokine biosynthetic process GO:0045080 9.43 HMOX1 TNF
17 immune system process GO:0002376 9.43 CLEC7A NLRP3 SQSTM1 SYK TLR1 TLR2
18 cellular response to triacyl bacterial lipopeptide GO:0071727 9.37 TLR1 TLR2
19 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.32 TLR1 TLR2
20 inflammatory response GO:0006954 9.17 CLEC7A CXCL8 NLRP3 SYK TLR1 TLR2
21 detection of triacyl bacterial lipopeptide GO:0042495 9.16 TLR1 TLR2

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.26 NLRP3 TLR2
2 lipopeptide binding GO:0071723 9.16 TLR1 TLR2
3 signaling pattern recognition receptor activity GO:0008329 8.96 CLEC7A TLR2
4 Toll-like receptor binding GO:0035325 8.62 SYK TLR2

Sources for Mycobacterium Abscessus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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