MCID: MYC002
MIFTS: 51

Mycobacterium Avium Complex Disease

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Mycobacterium Avium Complex Disease

MalaCards integrated aliases for Mycobacterium Avium Complex Disease:

Name: Mycobacterium Avium Complex Disease 12 14
Mycobacterium Avium-Intracellulare Infection 50 42 69
Mycobacterium Avium Infection 12 69
Mycobacterium Avium Complex 12 50
Infection Due to Mycobacterium Intracellulare 12
Mycobacterium Avium-Intracellulare 50
Mycobacterium Avium 50
Mac Disease 12
Mai 50

Classifications:



External Ids:

Disease Ontology 12 DOID:2755
MeSH 42 D015270
NCIt 47 C36197
SNOMED-CT 64 14009004 373436002
UMLS 69 C0026916

Summaries for Mycobacterium Avium Complex Disease

NIH Rare Diseases : 50 mycobacterium avium complex (mac) refers to infections caused by two types of bacteria: mycobacterium avium and mycobacterium intracellulare. mac primarily affects people with compromised immune systems (for example from aids, hairy cell leukemia, or immunosuppressive chemotherapy) or underlying lung disease. symptoms can be non-specific and may include fever, sweats, weight loss, abdominal pain, fatigue, chronic diarrhea, and anemia. it may cause local disease affecting the central nervous system, lymph nodes, soft tissue, or bones; or, it may cause multi-system disease also affecting other organs and systems. mac is spread when the bacteria, found in water, soil and dust particles, are inhaled or ingested. treatment for mac varies depending on the type and may include antibiotics, antituberculosis drugs, and/or surgery. last updated: 12/21/2015

MalaCards based summary : Mycobacterium Avium Complex Disease, also known as mycobacterium avium-intracellulare infection, is related to lymphoma and kaposi sarcoma. An important gene associated with Mycobacterium Avium Complex Disease is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clarithromycin and Clofazimine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and liver, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.

Wikipedia : 72 Mycobacterium avium-intracellulare infection (MAI) is an atypical mycobacterial infection, i.e. one with... more...

Related Diseases for Mycobacterium Avium Complex Disease

Diseases related to Mycobacterium Avium Complex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.3 IL10 IL6 TNF
2 kaposi sarcoma 29.9 IL6 SLC11A1 TNF
3 may-hegglin anomaly 12.2
4 disseminated infection with mycobacterium avium complex 12.2
5 may-thurner syndrome 12.1
6 myh9 related thrombocytopenia 11.2
7 immunodeficiency 31a, mycobacteriosis, autosomal dominant 11.1
8 androgen insensitivity syndrome, mild 11.0
9 prostate cancer 10.7
10 pure autonomic failure 10.7 IL10 TNF
11 acute ackee fruit intoxication 10.7 IL10 TNF
12 multiple familial trichoepithelioma 10.7 IL10 TNF
13 basidiobolomycosis 10.7 IL10 TNF
14 lagophthalmos 10.7 IL10 TNF
15 breast cancer 10.7
16 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
17 endosalpingiosis 10.7 IL10 TNF
18 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
19 essential tremor 10.6
20 idiopathic dilatation of the pulmonary artery 10.6 IL10 TNF
21 lupus erythematosus 10.6
22 schizophrenia 10.6
23 liver leiomyoma 10.6 IL10 TNF
24 encephalitis 10.6
25 aortic arch interruption 10.6 IL6 TNF
26 tarsal tunnel syndrome 10.6 IL10 TNF
27 plantar wart 10.6 IL10 TNF
28 cutaneous leishmaniasis 10.6 IL6 TNF
29 oropharyngeal cancer, childhood 10.6 IL10 TNF
30 crohn's disease 10.6
31 spirillary rat-bite fever 10.6 IL6 TNF
32 toxoplasmosis 10.6 IL6 TNF
33 dermatomyositis 10.6
34 dyslexia 5 10.6 IL6 TNF
35 chronic apical periodontitis 10.6 IL10 TNF
36 epstein-barr virus hepatitis 10.6 IL6 TNF
37 scrotal carcinoma 10.6 IL6 TNF
38 anencephaly and spina bifida x-linked 10.6 IL6 TNF
39 antigen-peptide-transporter 2 deficiency 10.6 IL6 TNF
40 vaginitis 10.6
41 papilledema 10.6 IL6 TNF
42 peroneal nerve paralysis 10.6 IL10 IL6
43 herpes zoster 10.6
44 spindle cell hemangioma 10.6 IL10 TNF
45 upper gum cancer 10.6 IL6 TNF
46 potato nose 10.6 IL6 TNF
47 drug rash with eosinophilia and systemic symptoms 10.6 IL10 IL6
48 alkhurma hemorrhagic fever 10.6 IL10 TNF
49 syringomyelia 10.6
50 multiple myeloma 10.6

Graphical network of the top 20 diseases related to Mycobacterium Avium Complex Disease:



Diseases related to Mycobacterium Avium Complex Disease

Symptoms & Phenotypes for Mycobacterium Avium Complex Disease

MGI Mouse Phenotypes related to Mycobacterium Avium Complex Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 SLC11A1 TNF IFNGR1 IL10 IL12RB1 IL31RA
2 digestive/alimentary MP:0005381 9.72 IFNGR1 IL10 IL6 SLC11A1 TNF
3 immune system MP:0005387 9.7 IFNGR1 IL10 IL12RB1 IL31RA IL6 SLC11A1
4 neoplasm MP:0002006 9.35 IFNGR1 IL10 IL6 SLC11A1 TNF
5 skeleton MP:0005390 9.1 BMP6 IFNGR1 IL10 IL31RA IL6 TNF

Drugs & Therapeutics for Mycobacterium Avium Complex Disease

Drugs for Mycobacterium Avium Complex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 670)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1 81103-11-9 84029
2
Clofazimine Approved, Investigational Phase 4,Phase 3,Phase 2 2030-63-9 2794
3
Rifabutin Approved Phase 4,Phase 3,Phase 2,Phase 1 72559-06-9 6323490
4
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
5
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
6
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
9
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
10
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
11
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
13
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
14 Racepinephrine Approved Phase 4,Phase 3
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
17
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
18
Topiramate Approved Phase 4,Phase 2,Phase 3 97240-79-4 5284627
19
Desflurane Approved Phase 4,Phase 3,Phase 2 57041-67-5 42113
20
Isoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 26675-46-7 3763
21
Montelukast Approved Phase 4 158966-92-8 5281040
22
Oxymetazoline Approved Phase 4 1491-59-4 4636
23
Phenylephrine Approved Phase 4 59-42-7 6041
24
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
25
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
26
Iron Approved Phase 4,Phase 2,Phase 1 7439-89-6 23925
27
Lopinavir Approved Phase 4,Phase 2,Phase 3,Phase 1 192725-17-0 92727
28
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
29
Ethambutol Approved Phase 4,Phase 3,Phase 2 74-55-5 3279 14052
30
Rifampin Approved Phase 4,Phase 3,Phase 2,Phase 1 13292-46-1 5458213 5381226
31
Ciprofloxacin Approved, Investigational Phase 4,Phase 2 85721-33-1 2764
32
Zoledronic acid Approved Phase 4 118072-93-8 68740
33
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
34
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3 58-14-0 4993
35
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
36
Sulfamethoxazole Approved Phase 4 723-46-6 5329
37
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
38
Darbepoetin alfa Approved, Investigational Phase 4,Phase 3 11096-26-7, 209810-58-2
39
Budesonide Approved Phase 4 51333-22-3 63006 5281004
40
Amodiaquine Approved Phase 4 86-42-0 2165
41
Artemether Approved Phase 4 71963-77-4 119380 68911
42
Artesunate Approved Phase 4 88495-63-0 6917864 5464098
43
Lumefantrine Approved Phase 4 82186-77-4 6437380
44
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
45
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2 154598-52-4 64139
46
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
47
Etanercept Approved, Investigational Phase 4 185243-69-0
48
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
49
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
50
Acetaminophen Approved Phase 4 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 585)

id Name Status NCT ID Phase Drugs
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
2 Deep Neuromuscular Blockade During Robotic Radical Prostatectomy Unknown status NCT02513693 Phase 4 Standard neuromuscular blockade;Deep neuromuscular blockade
3 Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
4 Safety Evaluation of Dexmedetomidine for EBUS-TBNA Unknown status NCT01381627 Phase 4 Remifentanil;Dexmedetomidine
5 Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients Unknown status NCT01710163 Phase 4 Lithium;Aripiprazole
6 Macugen for Proliferative Diabetic Retinopathy Study With Extended Dosing (M-PDRS ED) Unknown status NCT01486771 Phase 4 Macugen ® (pegaptanib sodium)
7 Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
8 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4 Topiramate
9 Desflurane-induced Myocardial Protection Unknown status NCT02019797 Phase 4 Desflurane
10 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4 Montelukast;Placebo
11 ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia Unknown status NCT01415284 Phase 4 Hydroxyethylstarch 130/0.4
12 Azithromycin in the Treatment of M. Avium Complex Lung Disease Completed NCT00599079 Phase 4 Azithromycin
13 Use of Clarithromycin and Rifabutin for the Treatment of M. Avium Complex (MAC) Lung Disease Completed NCT00598897 Phase 4 clarithromycin, rifabutin
14 Use of Azithromycin and Rifabutin Administered 3 Times Weekly for the Treatment of M. Avium Complex (MAC) Lung Disease Completed NCT00598962 Phase 4 Azithromycin;Rifabutin/rifampin
15 Clarithromycin v Ciprofloxacin Added to Rifampicin + Ethambutol, for Opportunist Mycobacterial Pulmonary Disease Completed NCT00367913 Phase 4 Addition of clarithromycin to rifampicin and ethambutol;Addition of Ciprofloxacin to rifampicin and ethambutol
16 Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients Completed NCT01129336 Phase 4 Zoledronic acid;Standard Therapy
17 Inflammation and Coronary Artery Disease: Role of AT1-Receptor Antagonism Completed NCT00274144 Phase 4 telmisartan 40 mg;placebo 40 mg
18 Clarithromycin for the Treatment of Infections Caused by Nontuberculous Mycobacteria (NTM) Completed NCT00600769 Phase 4 Clarithromycin
19 Hemodynamic Responses of Different Laryngoscopes Completed NCT02469363 Phase 4
20 Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Completed NCT00786812 Phase 4 Nilotinib
21 Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery Completed NCT01477151 Phase 4 Volatile anesthetic
22 Bispectral Index (BIS) Versus Electronic Alerts in the Prevention of Anesthesia Awareness: the Michigan Awareness Control Study Completed NCT00689091 Phase 4
23 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
24 Exploratory Phase II Study of INC424 Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
25 A Study of Rifabutin, Used Alone or With Ethambutol in the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in Patients With AIDS Completed NCT00002343 Phase 4 Ethambutol hydrochloride;Rifabutin
26 A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropo Completed NCT00773513 Phase 4 Darbepoetin Alfa;Epoetin Alfa;Epoetin Beta;methoxy polyethylene glycol-epoetin beta
27 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
28 Efficacy and Tolerability of Symbicort as an add-on Treatment to Spiriva Compare With Spiriva Alone in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01397890 Phase 4 Budesonide/formoterol (Symbicort® Turbuhaler®);Tiotropium (SpirivaTM)
29 In Vivo Efficacy of Artemether-Lumefantrine and Artesunate-Amodiaquine for Uncomplicated P. Falciparum Malaria Completed NCT02637128 Phase 4 artemether-lumefantrine (AL);artesunate-amodiaquine (ASAQ)
30 Effects of Propofol and Isoflurane on Pulmonary Vascular Resistance Completed NCT01212523 Phase 4 propofol and isoflurane
31 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed NCT01310582 Phase 4 Desflurane;Sevoflurane
32 Immediate Versus Deferred Start of Anti-HIV Therapy in HIV-Infected Adults Being Treated for Tuberculosis Completed NCT00108862 Phase 4
33 Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening Completed NCT01578850 Phase 4 Etanercept;placebo
34 Safety and Efficacy Study of Paliperidone Extended Release (ER) Among Thai Schizophrenia Participants Completed NCT01387542 Phase 4 Paliperidone extended release (ER)
35 Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum. Completed NCT01930747 Phase 4 rocuronium;Sevoflurane;remifentanyl
36 A Study of EGb 761® (Tanakan®) in Dementia of Alzheimer Type Onset in Patients Suffering From Memory Complaints Completed NCT00276510 Phase 4 EGb 761® (Tanakan®)
37 Effect of Remifentanil on Postoperative Cognition Function in Patients Undergoing Major Abdominal Surgery Completed NCT01627873 Phase 4 Remifentanil;Fentanyl
38 A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nep Completed NCT00168857 Phase 4 telmisartan;losartan
39 Evaluating the Safety of Immediate Versus Deferred Isoniazid Preventive Therapy Among HIV-Infected Pregnant Women Completed NCT01494038 Phase 4 Isoniazid (INH);Placebo for isoniazid (INH)
40 A Study of Enfuvirtide (Fuzeon) in Participants With Advanced Human Immunodeficiency Virus (HIV) Infection Completed NCT02582983 Phase 4 Enfuvirtide
41 Does Saxagliptin Reduce the Risk of Cardiovascular Events When Used Alone or Added to Other Diabetes Medications Completed NCT01107886 Phase 4 Saxagliptin;Placebo
42 Low Dose Atazanavir/r Versus Standard Dose Atazanavir/r (LASA) Completed NCT01159223 Phase 4 ATV/r
43 IMPAACT 1077HS: Examining Benefits of HAART Continuation in Postpartum Women Completed NCT00955968 Phase 4 Highly active antiretroviral therapy (HAART)
44 CMR Rate of Newly Diagnosed CML-CP Patients Treated With Nilotinib Completed NCT01227577 Phase 4 Nilotinib
45 An Exploratory Trial to Assess the Improvement of Adverse Events in Chronic Myelogenous Leukemia Patients Treated With Imatinib When Switched to Nilotinib Treatment Completed NCT00980018 Phase 4 Nilotinib
46 Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited Settings Completed NCT00084136 Phase 4 Atazanavir;Didanosine (enteric-coated);Efavirenz;Emtricitabine;Emtricitabine/Tenofovir disoproxil fumarate;Lamivudine/Zidovudine
47 Hepatitis B Vaccination in HIV-infected Adults Completed NCT02713620 Phase 4
48 Hepatitis B Vaccination in HIV-infected Adults With Low CD4 Cell Counts Completed NCT02732054 Phase 4
49 Study Evaluating Whether the Bispectral Index Prevents Patients at Higher Risk From Being Awake During Surgery and Anesthesia Completed NCT00682825 Phase 4
50 Scalp Nerve Block and Opioid Consumption in Brain Surgery Completed NCT02057367 Phase 4 Scalp block with 0.5% plain Marcaine;Scalp block with 0.9% normal saline

Search NIH Clinical Center for Mycobacterium Avium Complex Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: mycobacterium avium-intracellulare infection

Genetic Tests for Mycobacterium Avium Complex Disease

Anatomical Context for Mycobacterium Avium Complex Disease

MalaCards organs/tissues related to Mycobacterium Avium Complex Disease:

39
Lung, Breast, Liver, Bone, Lymph Node, Testes, Heart

Publications for Mycobacterium Avium Complex Disease

Articles related to Mycobacterium Avium Complex Disease:

(show top 50) (show all 79)
id Title Authors Year
1
Mycobacterium avium Complex Disease. ( 28429679 )
2017
2
Impact of cavity and infiltration on pulmonary function and health-related quality of life in pulmonary Mycobacterium avium complex disease: A 3-dimensional computed tomographic analysis. ( 28427555 )
2017
3
Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease. ( 28922807 )
2017
4
The clinical efficacy of a clarithromycin-based regimen for Mycobacterium avium complex disease: A nationwide post-marketing study. ( 28254517 )
2017
5
Cerebral air embolism likely due to pulmonary Mycobacterium avium complex disease. ( 27206904 )
2016
6
Preliminary Evaluation of a Sitafloxacin-Containing Regimen for Relapsed or Refractory Pulmonary Mycobacterium avium Complex Disease. ( 27704005 )
2016
7
Increasing patients with pulmonary Mycobacterium avium complex disease and associated underlying diseases in Japan. ( 25640532 )
2015
8
Validation of a commercial serodiagnostic kit for diagnosing pulmonary Mycobacterium avium complex disease. ( 25519798 )
2015
9
Recurrence of Disseminated Mycobacterium avium Complex Disease in a Patient with Anti-Gamma Interferon Autoantibodies by Reinfection. ( 25653414 )
2015
10
Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes. ( 26819743 )
2015
11
Characteristics of pulmonary Mycobacterium avium complex disease diagnosed later in follow-up after negative mycobacterial study including bronchoscopy. ( 26365483 )
2015
12
Disseminated Mycobacterium avium complex disease in a patient with left ventricular assist device (Heart Mate II). ( 26397297 )
2015
13
Retrospective investigation of combination therapy with clarithromycin and levofloxacin for pulmonary Mycobacterium avium complex disease. ( 26819735 )
2015
14
Role of Th1/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease. ( 24446514 )
2014
15
Prevalence and risk factors for chronic co-infection in pulmonary Mycobacterium avium complex disease. ( 25478192 )
2014
16
Pilot quasi-randomized controlled study of herbal medicine Hochuekkito as an adjunct to conventional treatment for progressed pulmonary Mycobacterium avium complex disease. ( 25093868 )
2014
17
Serodiagnosis of Mycobacterium avium complex disease in humans: translational research from basic mycobacteriology to clinical medicine. ( 25241680 )
2014
18
Opinions Differ by Expertise in Mycobacterium avium Complex Disease. ( 24083335 )
2013
19
Clinical characteristics and prevalence of pneumothorax in patients with pulmonary Mycobacterium avium complex disease. ( 23196652 )
2013
20
High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease. ( 23676171 )
2013
21
The pharmacokinetics and pharmacodynamics of pulmonary Mycobacterium avium complex disease treatment. ( 22744719 )
2012
22
A Case of Follicular Bronchiolitis as the Histological Counterpart to Nodular Opacities in Bronchiectatic Mycobacterium avium Complex Disease. ( 23133778 )
2012
23
Distinguishing tuberculosis from Mycobacterium avium complex disease using an interferon-gamma release assay. ( 21756514 )
2011
24
Clinical usefulness of combination chemotherapy for pulmonary Mycobacterium avium complex disease. ( 21094662 )
2010
25
A case of familial pulmonary mycobacterium avium complex disease. ( 20467183 )
2010
26
Bronchoscopic microsampling to analyze the epithelial lining fluid of patients with pulmonary Mycobacterium avium complex disease. ( 18824886 )
2008
27
Mycobacterium avium complex disease: prognostic implication of high-resolution computed tomography findings. ( 18321941 )
2008
28
High-resolution computed tomography in Mycobacterium avium complex disease: one step forward, two steps back. ( 18757707 )
2008
29
Clinical factors on cavitary and nodular bronchiectatic types in pulmonary Mycobacterium avium complex disease. ( 18703856 )
2008
30
The microbiological and clinical effects of combined therapy according to guidelines on the treatment of pulmonary Mycobacterium avium complex disease in Japan - including a follow-up study. ( 16954651 )
2007
31
A double-blind randomized study of aminoglycoside infusion with combined therapy for pulmonary Mycobacterium avium complex disease. ( 16750618 )
2007
32
Sibling cases of Mycobacterium avium complex disease associated with hematological disease. ( 17109096 )
2006
33
Chronic necrotizing pulmonary aspergillosis as a complication of pulmonary Mycobacterium avium complex disease. ( 17052313 )
2006
34
Relationship between clinical efficacy of treatment of pulmonary Mycobacterium avium complex disease and drug-sensitivity testing of Mycobacterium avium complex isolates. ( 16944258 )
2006
35
Chronic necrotizing pulmonary aspergillosis complicated by a cavitary lesion caused by Pulmonary Mycobacterium-avium complex disease. ( 15805716 )
2005
36
Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG study. ( 16131307 )
2005
37
SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease. ( 15328125 )
2004
38
A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome. ( 14557969 )
2003
39
Clinical analysis of pulmonary Mycobacterium avium complex disease in association with corticosteroid treatment. ( 12673411 )
2003
40
Head and neck manifestation of mycobacterium avium complex disease as a consequence of return of immunocompetency in AIDS. ( 11743478 )
2001
41
Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000. ( 11692307 )
2001
42
Serum interleukin-6 (IL-6), IL-10, tumor necrosis factor (TNF) alpha, soluble type II TNF receptor, and transforming growth factor beta levels in human immunodeficiency virus type 1-infected individuals with Mycobacterium avium complex disease. ( 11136787 )
2001
43
Familial pulmonary Mycobacterium avium complex disease. ( 10806169 )
2000
44
Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: A randomized, double-blind, placebo-controlled trial. The AIDS Clinical Trials Group 196/Terry Beirn Community Programs for Clinical Research on AIDS 009 Protocol Team. ( 10762562 )
2000
45
Discontinuation of prophylaxis for Mycobacterium avium complex disease in HIV-infected patients who have a response to antiretroviral therapy. Terry Beirn Community Programs for Clinical Research on AIDS. ( 10766581 )
2000
46
Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. ( 11020135 )
2000
47
Potential association between calcified thoracic lymphadenopathy due to previous Histoplasma capsulatum infection and pulmonary Mycobacterium avium complex disease. ( 10372850 )
1999
48
A prospective randomized trial of four three-drug regimens in the treatment of disseminated Mycobacterium avium complex disease in AIDS patients: excess mortality associated with high-dose clarithromycin. Terry Beirn Community Programs for Clinical Research on AIDS. ( 10433575 )
1999
49
The pathophysiology of disseminated Mycobacterium avium complex disease in AIDS. ( 10099120 )
1999
50
Pulmonary Mycobacterium avium complex disease without dissemination in HIV-infected patients. ( 9498982 )
1998

Variations for Mycobacterium Avium Complex Disease

Expression for Mycobacterium Avium Complex Disease

Search GEO for disease gene expression data for Mycobacterium Avium Complex Disease.

Pathways for Mycobacterium Avium Complex Disease

Pathways related to Mycobacterium Avium Complex Disease according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 IFNGR1 IL10 IL12RB1 IL31RA IL6 SLC11A1
2
Show member pathways
13.43 BMP6 IFNGR1 IL10 IL12RB1 IL6 TNF
3
Show member pathways
13.3 BMP6 IFNGR1 IL10 IL12RB1 IL6 TNF
4
Show member pathways
13.21 BMP6 IL10 IL12RB1 IL6 TNF
5
Show member pathways
13.1 IFNGR1 IL10 IL12RB1 IL31RA IL6 TNF
6
Show member pathways
13.09 BMP6 IL10 IL12RB1 IL6 TNF
7
Show member pathways
12.7 IFNGR1 IL10 IL6 TNF
8
Show member pathways
12.45 IFNGR1 IL10 IL12RB1 TNF
9
Show member pathways
12.4 IL10 IL12RB1 IL6 TNF
10
Show member pathways
12.27 IL10 IL6 TNF
11
Show member pathways
12.12 IFNGR1 IL6 TNF
12
Show member pathways
12.11 IFNGR1 IL10 TNF
13
Show member pathways
12.04 IFNGR1 IL6 TNF
14 12.04 IFNGR1 IL6 TNF
15 12.02 IL10 IL6 TNF
16
Show member pathways
12 IL10 IL6 TNF
17 11.99 IFNGR1 IL10 IL6 TNF
18
Show member pathways
11.94 IFNGR1 IL10 IL12RB1 IL6
19
Show member pathways
11.89 IFNGR1 IL10 IL12RB1 IL6 TNF
20 11.85 IL10 IL6 TNF
21 11.83 IL10 IL6 TNF
22 11.73 IL10 IL6 TNF
23 11.64 IL10 IL12RB1 TNF
24 11.6 IL10 IL6 TNF
25 11.59 IL10 IL6 TNF
26 11.55 IL10 IL6 TNF
27 11.4 IFNGR1 IL10 IL12RB1 IL6
28 11.36 IL10 IL6 TNF
29 11.34 IL10 IL6 TNF
30 11.31 IFNGR1 IL6
31
Show member pathways
11.28 IL10 TNF
32 11.18 IL6 TNF
33 11.16 IL6 TNF
34 11.09 IL10 IL6 TNF
35
Show member pathways
11.05 IFNGR1 IL10 IL12RB1 IL6 TNF
36 11.04 IL10 IL6 TNF
37 11 IL6 TNF
38 10.99 BMP6 IL10 IL6 TNF
39 10.92 IL6 TNF
40 10.91 IL10 IL6 TNF

GO Terms for Mycobacterium Avium Complex Disease

Cellular components related to Mycobacterium Avium Complex Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IL12RB1 IL31RA IL6 TNF

Biological processes related to Mycobacterium Avium Complex Disease according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.96 BMP6 IL10 IL6 SLC11A1 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.91 IL10 IL31RA IL6 TNF
3 defense response to bacterium GO:0042742 9.8 IL10 SLC11A1 TNF
4 response to lipopolysaccharide GO:0032496 9.79 IL10 IL6 SLC11A1
5 cytokine-mediated signaling pathway GO:0019221 9.77 IL12RB1 IL31RA IL6
6 cellular response to lipopolysaccharide GO:0071222 9.72 IL10 IL6 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.7 IL10 IL6 TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.66 IL6 TNF
9 response to activity GO:0014823 9.65 BMP6 IL10
10 cellular response to estradiol stimulus GO:0071392 9.65 IL10 IL6
11 response to bacterium GO:0009617 9.65 IL6 SLC11A1
12 immune response GO:0006955 9.65 BMP6 IL10 IL6 SLC11A1 TNF
13 negative regulation of mitotic cell cycle GO:0045930 9.64 IL10 TNF
14 positive regulation of phagocytosis GO:0050766 9.64 SLC11A1 TNF
15 positive regulation of cytokine secretion GO:0050715 9.63 IL10 TNF
16 positive regulation of cytokine production GO:0001819 9.62 SLC11A1 TNF
17 negative regulation of interleukin-6 production GO:0032715 9.62 IL10 TNF
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.6 IL10 TNF
19 positive regulation of chemokine production GO:0032722 9.58 IL6 TNF
20 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
21 cellular response to hepatocyte growth factor stimulus GO:0035729 9.57 IL10 IL6
22 inflammatory response GO:0006954 9.55 BMP6 IL10 IL6 SLC11A1 TNF
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL10 TNF
24 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
25 positive regulation of interferon-gamma production GO:0032729 9.5 IL12RB1 SLC11A1 TNF
26 multicellular organismal iron ion homeostasis GO:0060586 9.49 BMP6 SLC11A1
27 positive regulation of T-helper 1 type immune response GO:0002827 9.48 IL12RB1 SLC11A1
28 endothelial cell apoptotic process GO:0072577 9.46 IL10 TNF
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
30 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.4 IL6 TNF
31 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
32 defense response to protozoan GO:0042832 9.13 IL10 IL6 SLC11A1
33 response to glucocorticoid GO:0051384 8.92 BMP6 IL10 IL6 TNF

Molecular functions related to Mycobacterium Avium Complex Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP6 IL10 IL6
2 cytokine receptor activity GO:0004896 9.26 IL12RB1 IL31RA
3 cytokine activity GO:0005125 9.26 BMP6 IL10 IL6 TNF
4 cytokine binding GO:0019955 8.8 IFNGR1 IL12RB1 IL31RA

Sources for Mycobacterium Avium Complex Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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