MF
MCID: MYC006
MIFTS: 66

Mycosis Fungoides (MF) malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Mycosis Fungoides

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22Genetics Home Reference, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Mycosis fungoides is a disease in which t-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. this condition is one of the most common types of t-cell lymphoma. mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. the rash may last for months or years without causing any symptoms. over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. finally, tumors form which may develop into ulcers and become infected. mycosis fungoides is difficult to cure. treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life. last updated: 1/26/2011

MalaCards: Mycosis Fungoides, also known as alibert-bazin syndrome, is related to cutaneous t cell lymphoma and lymphomatoid papulosis. An important gene associated with Mycosis Fungoides is CCL17 (chemokine (C-C motif) ligand 17), and among its related pathways are CXCR3-mediated signaling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs cyclophosphamide and etoposide and the compounds ccl19 and etanercept have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Genetics Home Reference:22 Mycosis fungoides is the most common form of a type of cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain immune cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Although the skin is involved, the skin cells themselves are not cancerous. Mycosis fungoides usually occurs in adults over age 50, although affected children have been identified.

Wikipedia:66 Mycosis fungoides (also known as Alibert-Bazin syndrome or granuloma fungoides), is the most common form... more...

Description from OMIM:48 254400

Aliases & Classifications for Mycosis Fungoides

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9Disease Ontology, 44NIH Rare Diseases, 22Genetics Home Reference, 11DISEASES, 46Novoseek, 32LifeMap Discovery™, 63UMLS, 59SNOMED-CT, 36MeSH, 48OMIM, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

mycosis fungoides 9 44 22 11 46 32 63
alibert-bazin syndrome 44 22
granuloma fungoides 44 22
mycosis fungoides, unspecified site, extranodal and solid organ sites 9
mycosis fungoides of unspecified site 9
mycosis fungoides lymphoma 9
mycosis fungoides nos 9
mf 9


External Ids:

Disease Ontology9 DOID:8691
MeSH36 D009182
OMIM48 254400
ICD9CM28 202.1
NCIt41 C3246
ICD1026 C84.0

Related Diseases for Mycosis Fungoides

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18GeneCards, 19GeneDecks
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Diseases related to Mycosis Fungoides via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous t cell lymphoma31.3CDKN2B, TIA1, CXCL10, CXCR3, CCL17, IL2RB
2lymphomatoid papulosis31.3CCL17, TIA1, CXCR3
3dermatitis30.9CXCL11, CCL22, CXCR3, CCL17, CXCL10
4psoriasis30.8CCL17, CXCL10, CCR7, CCL22, CXCR1, CXCR3
5b-cell lymphomas30.7TIA1, CCL17, CXCR3, CDKN2B
6leukemia30.7IL2RB, CDKN2B, CD1A, TIA1, CCR7, CXCR3
7hodgkin's lymphoma30.6TIA1, CCL22, IL2RB, CCL17
8anaplastic large cell lymphoma30.5CCL17, IL2RB, CXCR3
9skin disease30.5CCL17, CXCR3, CXCL11, CXCL10, CXCR1
10non-hodgkin lymphoma30.4IL2RB, CDKN2B, CCR7
11lichen planus30.3CXCL11, CXCR3
12atopic dermatitis30.3CCL17, CCL22
13b-cell chronic lymphocytic leukemia30.3CCR7, IL2RB, CXCR3
14sarcoidosis30.3CXCL10, CXCR3, IL2RB
15peripheral t-cell lymphoma30.3CXCR3, IL2RB, TIA1
16hepatitis30.3CXCL10, IL2RB
17chronic lymphocytic leukemia30.2CXCR3, CCR7, CDKN2B
18systemic lupus erythematosus30.2CXCL10, IL2RB, CCR7, CXCR3
19uveitis30.2CXCL11, CXCR3, CXCR1, CXCL10
20ulcerative colitis30.2CCL17, CCL22, CXCL10, CXCR1, CXCR3
21melanoma30.1CD1A, IL2RB, CCR7, TIA1, CXCR1, CXCL10
22parapsoriasis10.9
23folliculotropic mycosis fungoides10.9
24follicular mucinosis10.8
25granuloma annulare10.6
26classical mycosis fungoides10.6
27alopecia10.5
28t-cell leukemia10.5
29pityriasis lichenoides10.5
30acanthosis nigricans10.5
31adult t-cell leukemia10.5
32vitiligo10.5
33xanthomatosis10.5
34myelofibrosis10.4
35hypohidrosis10.4
36composite lymphoma10.4
37lupus erythematosus10.4
38acute myelomonocytic leukemia10.4
39exfoliative dermatitis10.4
40hematopoietic stem cell transplantation10.4
41polycythemia vera10.3
42marfan syndrome10.3
43polycythemia10.3
44essential thrombocythemia10.3
45cutaneous lupus erythematosus10.3
46erysipelas10.3
47coccidioidomycosis10.3
48dermatophytosis10.3
49eosinophilia10.3
50leprosy10.3

Graphical network of the top 20 diseases related to Mycosis Fungoides:



Diseases related to mycosis fungoides

Symptoms for Mycosis Fungoides

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48OMIM
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Clinical features from OMIM:

254400

Drugs & Therapeutics for Mycosis Fungoides

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discovery™, 63UMLS, 42NDF-RT
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Genetic Tests for Mycosis Fungoides

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Anatomical Context for Mycosis Fungoides

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34MalaCards
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MalaCards organs/tissues related to Mycosis Fungoides:

34
T cells, Skin, B cells, Bone, Lung, Lymph node, Bone marrow, Testes, Colon, Myeloid, Thymus, Pancreas, Endothelial, Small intestine, Breast, Skeletal muscle, Eye, Liver, Pituitary

Animal Models for Mycosis Fungoides or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mycosis Fungoides:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1TIA1, CXCL10, CXCR3, CCL17, CCR7, IL2RB
2MP:00053976.8TIA1, CXCL10, CXCR3, CCL17, CCR7, IL2RB

Publications for Mycosis Fungoides

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53PubMed
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Articles related to Mycosis Fungoides:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. (24131357)
2013
2
Ultraviolet A1 phototherapy for mycosis fungoides. (23082901)
2013
3
Positron emission tomography computed tomography in large cell transformation of mycosis fungoides. (23724793)
2013
4
Epidermotropic marginal zone lymphoma simulating mycosis fungoides(a8 ). (23531038)
2013
5
CD8(+) mycosis fungoides with esophageal involvement: A case report. (23255897)
2013
6
Unilesional Mycosis Fungoides: 3 different clinical presentations. (23830487)
2013
7
Reversible pituitary insufficiency due to bexarotene therapy in a patient with mycosis fungoides. (24068455)
2013
8
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. (23013351)
2013
9
Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. (22542448)
2012
10
Successful treatment of a folliculotropic mycosis fungoides with bexarotene and PUVA. (22240623)
2012
11
Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience. (22044137)
2012
12
Follicular mucinosis and mycosis-fungoides-like drug eruption due to leuprolide acetate: a case report and review. (22882386)
2012
13
Unilesional follicular mycosis fungoides: report of two cases withA progression to tumor stage andA review of the literature. (22882174)
2012
14
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. (22121263)
2011
15
Mycosis fungoides stage IB progressing to cutaneous tumors. (22031631)
2011
16
Flow cytometric evaluation of skin biopsies for mycosis fungoides. (21552102)
2011
17
Simplified flow cytometric assessment in mycosis fungoides and SAczary syndrome. (22095381)
2011
18
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
19
More or less: copy number alterations in mycosis fungoides. (20231832)
2010
20
Free-floating collagen fibers in interstitial mycosis fungoides. (20145533)
2010
21
Immunoelectron microscopy in mycosis fungoides and benign dermatoses. Expression of CD3, CD4 and CD7 receptors. (19895171)
2010
22
Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous Lymphoma. (20128983)
2010
23
Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years. (19583687)
2009
24
Imiquimod in mycosis fungoides. (18424373)
2008
25
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
26
Safety and efficacy of low-dose bexarotene and PUVA in the treatment of patients with mycosis fungoides. (18429646)
2008
27
Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. (18349030)
2008
28
The treatment of unilesional mycosis fungoides with methyl aminolevulinate-photodynamic therapy. (18266688)
2008
29
Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. (18569636)
2008
30
Bexarotene monotherapy for patients with refractory early stage mycosis fungoides. (18405191)
2008
31
TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. (18204745)
2007
32
Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome. (17975162)
2007
33
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
34
Folliculotropic mycosis fungoides with CD30+ large-cell transformation in a young woman: beneficial effect of bexarotene. (17300259)
2007
35
Abnormal expression of interleukin-23 in mycosis fungoides/SAczary syndrome lesions. (17021762)
2006
36
Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. (16675558)
2006
37
Folliculotropic mycosis fungoides with central nervous system involvement: demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection. (12582395)
2003
38
p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides. (11850526)
2002
39
Alteration of cytokine genes and bcl-2 expression following immunotherapy with intralesional IFN-gamma in a patient with tumor-stage mycosis fungoides. (9621132)
1998
40
Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis? (9650701)
1998
41
Granulomatous mycosis fungoides with small intestinal involvement and a fatal outcome. (9580813)
1998
42
Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease. (7887663)
1995
43
Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells. (1731519)
1992
44
A case of classical mycosis fungoides associated with human T-cell lymphotropic virus type I. (2004007)
1991
45
Widespread eczematous dermatitis with erythematous facial plaques. Alopecia mucinosa (follicular mucinosis [FM]) with possible mycosis fungoides (MF). (1832536)
1991
46
Treatment of a case of mycosis fungoides and one of parapsoriasis en plaque with topical PUVA using a monofunctional furocoumarin derivative, 4,6,4'-trimethylangelicin. (2277144)
1990
47
Plutonium-induced mycosis fungoides and parapsoriasis en plaques--a new entity? (2298035)
1990
48
Follicular mucinosis, mycosis fungoides, and acute myeloid leukemia. (2341572)
1990
49
Depressed lymphokine activated killer cell activity in mycosis fungoides. A possible marker for aggressive disease. (2360838)
1990
50
Ultrastructure of abnormal cells in Sezary syndrome, mycosis fungoides, and parapsoriasis en plaque. (4253718)
1971

Variations for Mycosis Fungoides

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Expression for genes affiliated with Mycosis Fungoides

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mycosis Fungoides

Search GEO for disease gene expression data for Mycosis Fungoides.

Pathways for genes affiliated with Mycosis Fungoides

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Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 54QIAGEN, 55R&D Systems, 56Reactome, 31KEGG
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Pathways related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCL10, CXCL11, CXCR3
2
Show member pathways
Peptide GPCRs39
9.2CCR7, CXCR1, CXCR3
3
Show member pathways
8.3CCL22, CXCL10, CXCL11, CXCR3, CCL17, CCR7
4
Show member pathways
7.9CXCL10, CXCL11, CXCR3, CCL17, CCR7, IL2RB
5
Show member pathways
7.9CCL22, IL2RB, CXCL10, CXCL11, CXCR3, CCR7
6
Show member pathways
7.8CCL17, CXCL10, CXCL11, CXCR3, CXCR1, CCL22
7
Show member pathways
7.8CXCR1, CCR7, CXCR3, CXCL11, CXCL10, CCL22
8
Show member pathways
7.8CXCL10, CXCR1, CCL22, CXCL11, CXCR3, CCL17
9
Show member pathways
7.4IL2RB, CCL22, CCR7, CCL17, CXCR1, CXCR3
10
Show member pathways
7.1CXCL10, CXCL11, CDKN2B, IL2RB, CCL22, CCR7
11
Show member pathways
6.9CXCR3, CXCL11, CXCL10, CXCR1, CCR7, CCL17

Compounds for genes affiliated with Mycosis Fungoides

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30IUPHAR, 46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1ccl193010.1CXCR3, CCR7
2etanercept46 52 1212.0IL2RB, CXCR3
3methacholine46 52 1211.9IL2RB, CCL22
4[alcl]469.8CCL17, TIA1
52,5-oligoadenylate469.8CXCL10, IL2RB
6allergens469.7CCL17, CXCR3, CXCL10
7infliximab46 52 1211.6IL2RB, CXCR3, CXCL10
8ifn-alpha469.6IL2RB, CXCR3, CXCL10
9larc469.6CXCR3, CCL17, CCR7, CCL22
10fitc469.5CXCR1, CCR7, IL2RB
11ribavirin46 52 1211.5CXCR3, CXCL10
12groalpha469.5CXCR1, CXCR3, CXCL10
13cyclosporin a46 30 6211.5CXCL11, CCL17, CCL22, IL2RB
14matrigel469.5CXCL10, CXCR3, CCR7
15il 10469.4CXCL10, CXCR3, CCL17, IL2RB
16neopterin469.3IL2RB, CXCL10
17histamine46 30 2511.3CXCL10, CXCR3, CCL22, IL2RB
18superoxide46 2510.3IL2RB, CXCR1, CXCR3
19wortmannin469.3CXCL10, CXCR3, CXCR1
20nitric oxide46 25 1211.2IL2RB, CCL17, CXCR3, CXCL10
21progesterone46 30 62 25 1213.2CXCL10, CXCL11, CXCR3, IL2RB
22leukotriene b446 62 2511.1CXCL10, CXCR1, CCL22, IL2RB
23endotoxin469.1CXCL10, CXCR3, CXCR1, IL2RB
24genistein46 30 62 3 25 1214.1CXCL10, CXCR1, IL2RB
25vegf469.0IL2RB, CXCR1, CXCR3, CXCL10
26pge2468.9CXCL10, CXCR3, CCR7, CCL22, IL2RB
27ccl446 309.7CXCL10, CXCL11, CXCR3, CCL17, CCR7, CCL22
28tacrolimus46 52 1210.7CXCL10, CXCR3, CCL17, CCR7, CCL22, IL2RB
29phosphatidylinositol468.7CXCL10, CXCR3, CXCR1, CCR7, IL2RB
30lipid468.5CD1A, IL2RB, CCR7, CXCR1, CXCL10
31retinoic acid46 259.3CDKN2B, IL2RB, CXCR1, CXCL10
32dexamethasone46 52 30 1211.2CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCL22
33ccl346 309.2CCL22, CXCL10, CCR7, CCL17, CXCR1, CXCR3
34tarc468.2CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
35tyrosine467.8CXCL10, CXCR3, CXCR1, CCR7, IL2RB, CDKN2B
36rantes467.8CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
37calcium46 52 25 1210.8CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7

GO Terms for genes affiliated with Mycosis Fungoides

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17Gene Ontology
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Cellular components related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0CCL22, CCL17, CXCL11, CXCL10
2external side of plasma membraneGO:0098978.5IL2RB, CCR7, CXCR3, CXCL10

Biological processes related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell chemotaxisGO:0603269.8CCL22, CCL17
2negative regulation of angiogenesisGO:0165259.6CXCR3, CXCL10
3dendritic cell chemotaxisGO:0024079.6CCR7, CXCR1
4positive regulation of cAMP metabolic processGO:0308169.5CXCL10, CXCL11, CXCR3
5T cell chemotaxisGO:0108189.5CXCL11, CXCR3, CXCL10
6positive regulation of cAMP-mediated signalingGO:0439509.5CXCR3, CXCL10, CXCL11
7positive regulation of release of sequestered calcium ion into cytosolGO:0512819.4CXCR3, CXCL10, CXCL11
8cell-cell signalingGO:0072679.1CCL17, CXCL11, CCL22, CXCL10
9cell surface receptor signaling pathwayGO:0071669.1CXCL10, CXCR1, CXCR3
10chemokine-mediated signaling pathwayGO:0700988.9CXCL11, CXCR1, CXCL10, CCR7
11signal transductionGO:0071658.6IL2RB, CCL22, CXCL10, CXCL11
12G-protein coupled receptor signaling pathwayGO:0071868.6CXCR1, CXCR3, CCL17, CCR7, CXCL10
13chemotaxisGO:0069358.5CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCL22
14immune responseGO:0069558.4CXCL10, CXCL11, CCL17, CCR7, CCL22, CD1A
15inflammatory responseGO:0069548.1CXCL11, CXCR3, CXCR1, CCL17, CCR7, CCL22

Molecular functions related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.6CXCR1, CXCR3
2CXCR3 chemokine receptor bindingGO:0482489.3CXCL11, CXCL10
3chemokine activityGO:0080098.9CCL22, CCL17, CXCL11, CXCL10

Products for genes affiliated with Mycosis Fungoides

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Sources for Mycosis Fungoides

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet