Mycosis Fungoides malady
Categories: Rare diseases, Cancer diseases, Skin diseases, Blood diseases, Immune diseases
Aliases & Descriptions for Mycosis Fungoides:
Orphanet epidemiological data:52
mycosis fungoides, alibert-bazin type:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases, Blood diseases, Immune diseases
ICD10: 29 28
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
NIH Rare Diseases:46 Mycosis fungoides is a disease in which t-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. this condition is one of the most common types of t-cell lymphoma. mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. the rash may last for months or years without causing any symptoms. over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. finally, tumors form which may develop into ulcers and become infected. mycosis fungoides is difficult to cure. treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life. last updated: 1/26/2011
MalaCards based summary: Mycosis Fungoides, also known as alibert-bazin syndrome, is related to systemic lupus erythematosus and folliculotropic mycosis fungoides, and has symptoms including dry skin, eczema and skin rash. An important gene associated with Mycosis Fungoides is TNFRSF1B (TNF Receptor Superfamily Member 1B), and among its related pathways are IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Rheumatoid arthritis. The drugs cyclophosphamide and etoposide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone, and related mouse phenotypes are digestive/alimentary and neoplasm.
Genetics Home Reference:24 Mycosis fungoides is the most common form of a type of blood cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Although the skin is involved, the skin cells themselves are not cancerous. Mycosis fungoides usually occurs in adults over age 50, although affected children have been identified.
OMIM:50 Mycosis fungoides is a malignant T-cell lymphoma of the skin, first reported (and named) by Alibert (1835). (254400) more...
Wikipedia:69 Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form... more...
Symptoms by clinical synopsis from OMIM:254400
Clinical features from OMIM:254400
Symptoms:52 (show all 23)
HPO human phenotypes related to Mycosis Fungoides:(show all 27)
UMLS symptoms related to Mycosis Fungoides:umbilical discharge, osler's node, abnormal granulation tissue, skin symptom
FDA approved drugs:
Drugs for Mycosis Fungoides (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 190)
Interventional clinical trials:(show top 50) (show all 367)
Search NIH Clinical Center for Mycosis Fungoides
Inferred drug relations via UMLS66/NDF-RT44:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Mycosis Fungoides cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Mycosis Fungoides:
Embryonic/Adult Cultured Cells Related to Mycosis Fungoides:
MalaCards organs/tissues related to Mycosis Fungoides:34
T cells, Skin, Bone, Bone marrow, B cells, Lung, Breast
MGI Mouse Phenotypes related to Mycosis Fungoides:39
Articles related to Mycosis Fungoides:(show top 50) (show all 881)
Cosmic variations for Mycosis Fungoides:8
Search GEO for disease gene expression data for Mycosis Fungoides.
Pathways related to Mycosis Fungoides according to GeneCards Suite gene sharing:(show all 38)
Cellular components related to Mycosis Fungoides according to GeneCards Suite gene sharing:
Biological processes related to Mycosis Fungoides according to GeneCards Suite gene sharing:(show all 22)
Molecular functions related to Mycosis Fungoides according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet