MF
MCID: MYC006
MIFTS: 69

Mycosis Fungoides (MF) malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Mycosis Fungoides

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NIH Rare Diseases:42 Mycosis fungoides is a disease in which t-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. this condition is one of the most common types of t-cell lymphoma. mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. the rash may last for months or years without causing any symptoms. over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. finally, tumors form which may develop into ulcers and become infected. mycosis fungoides is difficult to cure. treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life. last updated: 1/26/2011

MalaCards based summary: Mycosis Fungoides, also known as mycosis fungoides of unspecified site, is related to lymphomatoid papulosis and anaplastic large cell lymphoma. An important gene associated with Mycosis Fungoides is CCL17 (chemokine (C-C motif) ligand 17), and among its related pathways are CXCR3-mediated signaling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs cyclophosphamide and etoposide and the compounds ccl19 and etanercept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Genetics Home Reference:21 Mycosis fungoides is the most common form of a type of cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain immune cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Although the skin is involved, the skin cells themselves are not cancerous. Mycosis fungoides usually occurs in adults over age 50, although affected children have been identified.

Wikipedia:65 Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form... more...

Description from OMIM:46 254400

Aliases & Classifications for Mycosis Fungoides

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Mycosis Fungoides, Aliases & Descriptions:

Name: Mycosis Fungoides 30 8 42 21 10 44 62
Mycosis Fungoides of Unspecified Site 8 62
Mycosis Fungoides Lymphoma 8 62
Alibert-Bazin Syndrome 42 21
 
Granuloma Fungoides 42 21
Mycosis Fungoides, Unspecified Site, Extranodal and Solid Organ Sites 8
Mycosis Fungoides Nos 8
Mf 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:8691
OMIM46 254400
NCIt39 C3246
MeSH34 D009182
ICD9CM27 202.1
ICD1025 C84.0

Related Diseases for Mycosis Fungoides

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Diseases related to Mycosis Fungoides via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1lymphomatoid papulosis31.4CCL17, CXCR3, TIA1
2anaplastic large cell lymphoma30.8CXCR3, CCL17, IL2RB
3dermatitis30.8CXCL10, CXCL11, CXCR3, CCL17, CCL22
4lichen planus30.7CXCL11, CXCR3
5cutaneous t cell lymphoma30.6TIA1, CXCL10, CXCR3, CCL17, IL2RB, CDKN2B
6atopic dermatitis30.6CCL17, CCL22
7hodgkin's lymphoma30.6TIA1, CCL17, CCL22, IL2RB
8b-cell lymphomas30.5CDKN2B, CCL17, CXCR3, TIA1
9sarcoidosis30.4CXCL10, CXCR3, IL2RB
10psoriasis30.4CXCL10, CXCR3, CXCR1, CCL17, CCR7, CCL22
11peripheral t-cell lymphoma30.4TIA1, CXCR3, IL2RB
12hepatitis30.4CXCL10, IL2RB
13non-hodgkin lymphoma30.3CDKN2B, IL2RB, CCR7
14skin disease30.3CCL17, CXCR1, CXCR3, CXCL11, CXCL10
15chronic lymphocytic leukemia30.2CXCR3, CCR7, CDKN2B
16systemic lupus erythematosus30.2CXCL10, CXCR3, CCR7, IL2RB
17uveitis30.1CXCL10, CXCL11, CXCR3, CXCR1
18ulcerative colitis30.0CXCL10, CXCR3, CXCR1, CCL17, CCL22
19leukemia29.7TIA1, CXCR3, CXCR1, CCR7, IL2RB, CD1A
20melanoma28.8TIA1, CXCL10, CXCR3, CXCR1, CCR7, IL2RB
21folliculotropic mycosis fungoides11.0
22parapsoriasis10.9
23follicular mucinosis10.9
24granuloma annulare10.6
25classical mycosis fungoides10.6
26pityriasis lichenoides10.6
27alopecia10.6
28t-cell leukemia10.6
29paragonimiasis10.5CCL17
30adult t-cell leukemia10.5
31vitiligo10.5
32acanthosis nigricans10.5
33malaria10.5IL2RB
34hematopoietic stem cell transplantation10.5
35xanthomatosis10.5
36myelofibrosis10.4
37composite lymphoma10.4
38hypohidrosis10.4
39leprosy10.4
40lupus erythematosus10.4
41acute myelomonocytic leukemia10.4
42exfoliative dermatitis10.4
43eosinophilic pneumonia10.4CCL22, CCL17
44coccidioidomycosis10.3
45cutaneous lupus erythematosus10.3
46erysipelas10.3
47dermatophytosis10.3
48eosinophilia10.3
49lung cancer10.3
50nephrotic syndrome10.3

Graphical network of the top 20 diseases related to Mycosis Fungoides:



Diseases related to mycosis fungoides

Symptoms for Mycosis Fungoides

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Clinical features from OMIM:

254400

Drugs & Therapeutics for Mycosis Fungoides

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Genetic Tests for Mycosis Fungoides

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Anatomical Context for Mycosis Fungoides

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MalaCards organs/tissues related to Mycosis Fungoides:

32
Skin, T cells, B cells, Bone, Lung, Lymph node, Bone marrow, Thymus, Colon, Testes, Myeloid, Eye, Skeletal muscle, Small intestine, Liver, Pancreas, Breast, Endothelial, Pituitary, Neutrophil

Animal Models for Mycosis Fungoides or affiliated genes

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MGI Mouse Phenotypes related to Mycosis Fungoides:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1TIA1, CXCL10, CXCR3, CCL17, CCR7, IL2RB
2MP:00053976.8TIA1, CXCL10, CXCR3, CCL17, CCR7, IL2RB

Publications for Mycosis Fungoides

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Articles related to Mycosis Fungoides:

(show top 50)    (show all 763)
idTitleAuthorsYear
1
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. (24131357)
2013
2
Ultraviolet A1 phototherapy for mycosis fungoides. (23082901)
2013
3
Positron emission tomography computed tomography in large cell transformation of mycosis fungoides. (23724793)
2013
4
Epidermotropic marginal zone lymphoma simulating mycosis fungoides(a8 ). (23531038)
2013
5
CD8(+) mycosis fungoides with esophageal involvement: A case report. (23255897)
2013
6
Unilesional Mycosis Fungoides: 3 different clinical presentations. (23830487)
2013
7
Reversible pituitary insufficiency due to bexarotene therapy in a patient with mycosis fungoides. (24068455)
2013
8
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. (23013351)
2013
9
Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. (22542448)
2012
10
Successful treatment of a folliculotropic mycosis fungoides with bexarotene and PUVA. (22240623)
2012
11
Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience. (22044137)
2012
12
Follicular mucinosis and mycosis-fungoides-like drug eruption due to leuprolide acetate: a case report and review. (22882386)
2012
13
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. (22121263)
2011
14
Mycosis fungoides stage IB progressing to cutaneous tumors. (22031631)
2011
15
Flow cytometric evaluation of skin biopsies for mycosis fungoides. (21552102)
2011
16
Simplified flow cytometric assessment in mycosis fungoides and SAczary syndrome. (22095381)
2011
17
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
18
More or less: copy number alterations in mycosis fungoides. (20231832)
2010
19
Free-floating collagen fibers in interstitial mycosis fungoides. (20145533)
2010
20
Immunoelectron microscopy in mycosis fungoides and benign dermatoses. Expression of CD3, CD4 and CD7 receptors. (19895171)
2010
21
Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous Lymphoma. (20128983)
2010
22
Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years. (19583687)
2009
23
Imiquimod in mycosis fungoides. (18424373)
2008
24
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
25
Safety and efficacy of low-dose bexarotene and PUVA in the treatment of patients with mycosis fungoides. (18429646)
2008
26
Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. (18349030)
2008
27
The treatment of unilesional mycosis fungoides with methyl aminolevulinate-photodynamic therapy. (18266688)
2008
28
Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. (18569636)
2008
29
Bexarotene monotherapy for patients with refractory early stage mycosis fungoides. (18405191)
2008
30
TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. (18204745)
2007
31
Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome. (17975162)
2007
32
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
33
Folliculotropic mycosis fungoides with CD30+ large-cell transformation in a young woman: beneficial effect of bexarotene. (17300259)
2007
34
Abnormal expression of interleukin-23 in mycosis fungoides/SAczary syndrome lesions. (17021762)
2006
35
Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. (16675558)
2006
36
Folliculotropic mycosis fungoides with central nervous system involvement: demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection. (12582395)
2003
37
p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides. (11850526)
2002
38
Cytokine profile of patients with mycosis fungoides and the immunomodulatory effect of AS101. (11720171)
2001
39
Alteration of cytokine genes and bcl-2 expression following immunotherapy with intralesional IFN-gamma in a patient with tumor-stage mycosis fungoides. (9621132)
1998
40
Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis? (9650701)
1998
41
Granulomatous mycosis fungoides with small intestinal involvement and a fatal outcome. (9580813)
1998
42
Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease. (7887663)
1995
43
Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells. (1731519)
1992
44
A case of classical mycosis fungoides associated with human T-cell lymphotropic virus type I. (2004007)
1991
45
Widespread eczematous dermatitis with erythematous facial plaques. Alopecia mucinosa (follicular mucinosis [FM]) with possible mycosis fungoides (MF). (1832536)
1991
46
Treatment of a case of mycosis fungoides and one of parapsoriasis en plaque with topical PUVA using a monofunctional furocoumarin derivative, 4,6,4'-trimethylangelicin. (2277144)
1990
47
Plutonium-induced mycosis fungoides and parapsoriasis en plaques--a new entity? (2298035)
1990
48
Follicular mucinosis, mycosis fungoides, and acute myeloid leukemia. (2341572)
1990
49
Depressed lymphokine activated killer cell activity in mycosis fungoides. A possible marker for aggressive disease. (2360838)
1990
50
Ultrastructure of abnormal cells in Sezary syndrome, mycosis fungoides, and parapsoriasis en plaque. (4253718)
1971

Variations for Mycosis Fungoides

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Expression for genes affiliated with Mycosis Fungoides

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Expression patterns in normal tissues for genes affiliated with Mycosis Fungoides

Search GEO for disease gene expression data for Mycosis Fungoides.

Pathways for genes affiliated with Mycosis Fungoides

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Pathways related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCL10, CXCL11, CXCR3
2
Show member pathways
Peptide GPCRs37
9.2CCR7, CXCR1, CXCR3
3
Show member pathways
8.3CCL22, CXCL10, CXCL11, CXCR3, CCL17, CCR7
4
Show member pathways
7.9CXCL10, CXCL11, CXCR3, CCL17, CCR7, IL2RB
5
Show member pathways
7.9CCL22, IL2RB, CXCL10, CXCL11, CXCR3, CCR7
6
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7.8CCL17, CXCL10, CXCL11, CXCR3, CXCR1, CCL22
7
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7.8CXCR1, CCR7, CXCR3, CXCL11, CXCL10, CCL22
8
Show member pathways
7.8CXCL10, CXCR1, CCL22, CXCL11, CXCR3, CCL17
9
Show member pathways
7.4IL2RB, CCL22, CCR7, CCL17, CXCR1, CXCR3
10
Show member pathways
7.1CXCL10, CXCL11, CDKN2B, IL2RB, CCL22, CCR7
11
Show member pathways
6.9CXCR3, CXCL11, CXCL10, CXCR1, CCR7, CCL17

Compounds for genes affiliated with Mycosis Fungoides

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Compounds related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1ccl192810.1CXCR3, CCR7
2etanercept44 50 1112.0CXCR3, IL2RB
3methacholine44 50 1111.9CCL22, IL2RB
4[alcl]449.8TIA1, CCL17
52,5-oligoadenylate449.8CXCL10, IL2RB
6allergens449.7CXCL10, CXCR3, CCL17
7infliximab44 50 1111.6CXCR3, CXCL10, IL2RB
8ifn-alpha449.6IL2RB, CXCR3, CXCL10
9larc449.6CCL22, CXCR3, CCL17, CCR7
10fitc449.5CCR7, CXCR1, IL2RB
11ribavirin44 50 1111.5CXCR3, CXCL10
12groalpha449.5CXCL10, CXCR1, CXCR3
13cyclosporin a44 28 6111.5IL2RB, CCL22, CXCL11, CCL17
14matrigel449.5CXCR3, CXCL10, CCR7
15il 10449.4CXCL10, CXCR3, CCL17, IL2RB
16neopterin449.3CXCL10, IL2RB
17histamine44 28 2411.3CXCR3, CCL22, CXCL10, IL2RB
18wortmannin449.3CXCR1, CXCR3, CXCL10
19superoxide44 2410.3IL2RB, CXCR1, CXCR3
20nitric oxide44 24 1111.2IL2RB, CCL17, CXCL10, CXCR3
21progesterone44 28 61 24 1113.2CXCR3, CXCL10, CXCL11, IL2RB
22leukotriene b444 61 2411.1CXCR1, CCL22, CXCL10, IL2RB
23endotoxin449.1IL2RB, CXCR3, CXCL10, CXCR1
24genistein44 28 61 2 24 1114.1CXCL10, IL2RB, CXCR1
25vegf449.0IL2RB, CXCL10, CXCR1, CXCR3
26pge2448.9CCR7, CXCR3, CXCL10, CCL22, IL2RB
27ccl444 289.7CCR7, CXCL10, CXCL11, CCL17, CXCR3, CCL22
28tacrolimus44 50 1110.7CXCL10, CXCR3, IL2RB, CCL22, CCR7, CCL17
29phosphatidylinositol448.7CXCR3, CXCL10, IL2RB, CXCR1, CCR7
30lipid448.5CCR7, CXCR1, IL2RB, CXCL10, CD1A
31retinoic acid44 249.3IL2RB, CDKN2B, CXCL10, CXCR1
32dexamethasone44 50 28 1111.2CCL17, CXCR1, IL2RB, CXCR3, CCL22, CXCL10
33tarc448.2CXCL10, CCL17, CCL22, CCR7, CXCR1, CXCR3
34ccl344 289.2CCL22, CCR7, CCL17, CXCR1, CXCR3, CXCL11
35tyrosine447.8CDKN2B, CXCL10, CXCR3, CCR7, IL2RB, CXCR1
36rantes447.8CXCR3, CXCR1, CCL17, CCR7, CCL22, IL2RB
37calcium44 50 24 1110.8IL2RB, CXCL11, CCL22, CCR7, CCL17, CXCL10

GO Terms for genes affiliated with Mycosis Fungoides

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Cellular components related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0CCL22, CCL17, CXCL11, CXCL10
2external side of plasma membraneGO:0098978.5IL2RB, CCR7, CXCR3, CXCL10

Biological processes related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell chemotaxisGO:0603269.8CCL22, CCL17
2negative regulation of angiogenesisGO:0165259.6CXCR3, CXCL10
3dendritic cell chemotaxisGO:0024079.6CCR7, CXCR1
4positive regulation of cAMP metabolic processGO:0308169.5CXCL10, CXCL11, CXCR3
5T cell chemotaxisGO:0108189.5CXCL11, CXCR3, CXCL10
6positive regulation of cAMP-mediated signalingGO:0439509.5CXCR3, CXCL10, CXCL11
7positive regulation of release of sequestered calcium ion into cytosolGO:0512819.4CXCR3, CXCL10, CXCL11
8cell-cell signalingGO:0072679.1CCL17, CXCL11, CCL22, CXCL10
9cell surface receptor signaling pathwayGO:0071669.1CXCL10, CXCR1, CXCR3
10chemokine-mediated signaling pathwayGO:0700988.9CXCL11, CXCR1, CXCL10, CCR7
11signal transductionGO:0071658.6IL2RB, CCL22, CXCL10, CXCL11
12G-protein coupled receptor signaling pathwayGO:0071868.6CXCR1, CXCR3, CCL17, CCR7, CXCL10
13chemotaxisGO:0069358.5CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCL22
14immune responseGO:0069558.4CXCL10, CXCL11, CCL17, CCR7, CCL22, CD1A
15inflammatory responseGO:0069548.1CXCL11, CXCR3, CXCR1, CCL17, CCR7, CCL22

Molecular functions related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.6CXCR1, CXCR3
2CXCR3 chemokine receptor bindingGO:0482489.3CXCL11, CXCL10
3chemokine activityGO:0080098.9CCL22, CCL17, CXCL11, CXCL10

Products for genes affiliated with Mycosis Fungoides

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