MF
MCID: MYC006
MIFTS: 71

Mycosis Fungoides (MF) malady

Cancer diseases, Immune diseases categories

Summaries for Mycosis Fungoides

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42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Mycosis fungoides is a disease in which t-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. this condition is one of the most common types of t-cell lymphoma. mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. the rash may last for months or years without causing any symptoms. over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. finally, tumors form which may develop into ulcers and become infected. mycosis fungoides is difficult to cure. treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life. last updated: 1/26/2011

MalaCards: Mycosis Fungoides, also known as alibert-bazin syndrome, is related to cutaneous t cell lymphoma and leukemia. An important gene associated with Mycosis Fungoides is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are Akt Signaling and PAK Pathway. The drugs cyclophosphamide and etoposide and the compounds calcium and tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are cellular and immune system.

Genetics Home Reference:21 Mycosis fungoides is the most common form of a type of cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain immune cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Although the skin is involved, the skin cells themselves are not cancerous. Mycosis fungoides usually occurs in adults over age 50, although affected children have been identified.

Wikipedia:63 Mycosis fungoides (also known as Alibert-Bazin syndrome or granuloma fungoides), is the most common form... more...

Description from OMIM:46 254400

Aliases & Classifications for Mycosis Fungoides

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 46OMIM, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

mycosis fungoides 8 42 21 10 44 30 60
alibert-bazin syndrome 42 21
granuloma fungoides 42 21
mycosis fungoides, unspecified site, extranodal and solid organ sites 8
mycosis fungoides of unspecified site 8
mycosis fungoides lymphoma 8
mycosis fungoides nos 8
mf 8


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Disease Ontology8 DOID:8691
MeSH34 D009182
OMIM46 254400
NCIt39 C3246
ICD9CM27 202.1
ICD1025 C84.0

Related Diseases for Mycosis Fungoides

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17GeneCards, 18GeneDecks
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Diseases related to Mycosis Fungoides via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous t cell lymphoma31.5CCR10, CCL17, CCR4, GZMB, TNFRSF8, IL2
2leukemia30.9CCR7, GZMB, IL2RB, IL7, IL2RA, CXCR3
3psoriasis30.8CCR10, CCL17, CCR4, CCR7, CCL22, GZMB
4dermatitis30.8CCL22, CCR4, CXCL9, CXCL10, CXCL11, CXCR3
5skin disease30.7IL7, CXCL9, CXCL10, CXCL11, CXCR3, CD7
6t-cell leukemia30.7CCR4, TNFRSF8, ITGAL, CD7, IL2RA, IL2RB
7hodgkin's lymphoma30.6CCL22, CCR4, IL2, CCL17, GZMB, TNFRSF8
8acute leukemia30.6IL2, IL7, CD7, CDKN2B
9lung cancer30.5IL2
10melanoma30.4CDKN2B, GZMB, CCR10, CCR4, CCR7, CD1A
11anaplastic large cell lymphoma30.4CCR4, CCL17, GZMB, TNFRSF8, CXCR3, IL2RA
12non-hodgkin lymphoma30.4CCR7, GZMB, TNFRSF8, ITGAL, CDKN2B, IL2RA
13eosinophilia30.4CCR4, CCL17, CCR3, IL2RA, IL2RB, IL2
14leprosy30.4IL2
15nephrotic syndrome30.4IL2RA
16sarcoidosis30.2CCR4, GZMB, CXCR3, CXCL10, CXCL9, IL2RA
17systemic lupus erythematosus30.2CCR7, CCR4, ITGAL, CXCR3, CXCL10, IL2RA
18uveitis30.2CCR4, CXCR3, CXCL11, CXCL10, CXCL9, IL2RA
19lichen planus30.2CXCL9, CXCL11, CXCR3, ITGAL, GZMB
20ulcerative colitis30.2CCL22, CCL17, GZMB, CXCR3, CXCL10, IL2RA
21chronic lymphocytic leukemia30.2CCR7, ITGAL, CDKN2B, CXCR3, IL2RA, IL7
22atopic dermatitis30.2CCR3, CCL17, CCL22
23myeloid leukemia30.1ITGAL, CDKN2B
24sarcoma30.1IL2, CD1A
25glomerulonephritis30.1ITGAL, CXCL9
26esophagitis30.1CCR3
27alopecia areata30.1GZMB
28kaposi's sarcoma30.1CXCL10, TNFRSF8, CCR3
29hepatitis30.1GZMB, CXCL10, IL2RB
30parapsoriasis10.9
31follicular mucinosis10.8
32granuloma annulare10.6
33alopecia10.5
34classical mycosis fungoides10.5
35acanthosis nigricans10.5
36adult t-cell leukemia10.5
37vitiligo10.5
38adult lymphoma10.4
39subcutaneous mycosis10.4
40xanthomatosis10.4
41folliculotropic mycosis fungoides10.4
42myelofibrosis10.4
43hypohidrosis10.4
44composite lymphoma10.4
45lupus erythematosus10.4
46primary systemic mycosis10.4
47marfan syndrome10.3
48polycythemia vera10.3
49polycythemia10.3
50cutaneous lupus erythematosus10.3

Graphical network of the top 20 diseases related to Mycosis Fungoides:



Diseases related to mycosis fungoides

Clinical Features for Mycosis Fungoides

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46OMIM
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Clinical features from OMIM:

254400

Drugs & Therapeutics for Mycosis Fungoides

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Genetic Tests for Mycosis Fungoides

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Anatomical Context for Mycosis Fungoides

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32MalaCards
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MalaCards organs/tissues related to Mycosis Fungoides:

32
Skin, T cells, B cells, Bone, Lung, Lymph node, Bone marrow, Colon, Thymus, Myeloid, Testes, Breast, Skeletal muscle, Pancreas, Small intestine, Liver, Eye, Endothelial, Pituitary

Animal Models for Mycosis Fungoides or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mycosis Fungoides:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.6CCR10, CCR3, GZMB, ITGAL, CDKN2B, CD7
2MP:000538710.6IL2, CCR7, CCR4, CCL17, CCR10, CCR3
3MP:000539710.3TNFRSF8, GZMB, CCR3, CCR10, CCR4, CCR7

Publications for Mycosis Fungoides

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50PubMed
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Articles related to Mycosis Fungoides:

(show top 50)    (show all 732)
idTitleAuthorsYear
1
Prognostic factors and risk stratification in early mycosis fungoides. (23547839)
2014
2
NKp46-Specific Expression on Skin-Resident CD4(+) Lymphocytes in Mycosis Fungoides and SAczary Syndrome. (23900021)
2014
3
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. (23013351)
2013
4
Dermoscopy of early stage mycosis fungoides. (22404051)
2013
5
miR-155 is involved in tumor progression of mycosis fungoides. (23711069)
2013
6
Racial differences in mycosis fungoides: a retrospective study with a focus on eosinophilia. (23374234)
2013
7
Clinicopathological features of mycosis fungoides in patients exposed to Agent Orange during the Vietnam War. (23724870)
2013
8
Hyperpigmented mycosis fungoides: a rare variant. (23898362)
2013
9
Allogeneic hematopoietic stem cell transplantation in mycosis fungoides. (24346924)
2013
10
Overexpression of hypoxia-inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides-Cutaneous T-cell lymphoma: Clinical implications. (24127318)
2013
11
Acral erosive mycosis fungoides: successful treatment with localised radiotherapy. (23595169)
2013
12
Reduced-intensity conditioning followed by cord blood transplantation in a patient with refractory folliculotropic mycosis fungoides. (23943312)
2013
13
Lymphoepithelioma-like carcinoma in a patient with mycosis fungoides. (22527441)
2012
14
Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. (21704421)
2012
15
Solitary mycosis fungoides: a distinct clinicopathologic entity with a good prognosis: a series of 15 cases and literature review. (22533993)
2012
16
A practical approach to accurate classification and staging of mycosis fungoides and SAczary syndrome. (23223768)
2012
17
Simplified flow cytometric assessment in mycosis fungoides and SAczary syndrome. (22095381)
2011
18
Treatment of ankylosing spondylitis by extracorporeal photochemotherapy given for mycosis fungoides: a potential treatment option? (21778904)
2011
19
Multicenter photopheresis intervention trial in early-stage mycosis fungoides. (21575927)
2011
20
Is PUVA maintenance therapy necessary in patients with early-stage mycosis fungoides? Evaluation of a treatment guideline over a 28-month follow-up. (21375528)
2011
21
miRNA expression profiling of mycosis fungoides. (21406335)
2011
22
Differential patterns of CXCR3, CCR3, and CCR10 expression in mycosis fungoides, Sezary syndrome and CD30(+) lymphoproliferative disorders: immunohistochemical study of 43 samples. (21868202)
2011
23
Clinical roundtable monograph. The management of aggressive T-cell lymphoma: a discussion on transformed mycosis fungoides. (21344783)
2010
24
Mycosis fungoides: A case report. (23100994)
2010
25
Folliculotropic mycosis fungoides: clinicopathological features and outcome in a series of 20 cases. (20079954)
2010
26
Prevalence of Human Herpesvirus-8 (HHV-8) in untreated patients with early stage Mycosis Fungoides (A retrospective study). (21475551)
2010
27
Phototherapy for mycosis fungoides in a patient with coincident systemic lupus erythematosus. (20466187)
2010
28
Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years. (19583687)
2009
29
Foreign-body-associated granulomatous slack skin in folliculotropic mycosis fungoides of childhood. (19476528)
2009
30
Low-dose gemcitabine efficacious in three patients with tumor-stage mycosis fungoides. (19858049)
2009
31
Analysis of extracutaneous spread in mycosis fungoides. (19554021)
2009
32
The conundrum of parapsoriasis versus patch stage of mycosis fungoides. (19439874)
2009
33
Flow cytometry immunophenotyping in mycosis fungoides. (18694688)
2008
34
Immunopathogenesis of mycosis fungoides/SAczary syndrome (cutaneous T-cell lymphoma). (19169210)
2008
35
Unilateral mycosis fungoides. (18713605)
2008
36
Denileukin diftitox therapy for patients with tumour-stage mycosis fungoides. (18405182)
2008
37
Mycosis fungoides: pathophysiology and emerging therapies. (18086343)
2007
38
Mycosis fungoides palmaris et plantaris--an unusual variant of cutaneous T-cell lymphoma. (16436350)
2006
39
Expression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome). (15305382)
2004
40
Folliculotropic mycosis fungoides with central nervous system involvement: demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection. (12582395)
2003
41
Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis. (11589730)
2001
42
Interferon-alpha-associated development of bullous lesions in mycosis fungoides. (10681616)
2000
43
Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis? (9650701)
1998
44
Yellow nail syndrome in a patient with mycosis fungoides. (8496432)
1993
45
Guttate parapsoriasis/digitate dermatosis (small plaque parapsoriasis) is mycosis fungoides. (1345135)
1992
46
Adenosine deaminase activity in sera of patients with psoriasis, mycosis fungoides and adult T cell leukemia. (1362831)
1992
47
Soluble IL2 receptor serum levels and epidermal cytokines in mycosis fungoides and related disorders. (1685826)
1991
48
Depressed lymphokine activated killer cell activity in mycosis fungoides. A possible marker for aggressive disease. (2360838)
1990
49
Immunotactoid glomerulopathy associated with mycosis fungoides. (2235815)
1990
50
Coexistence of pemphigus foliaceus and mycosis fungoides. (3158289)
1985

Genetic Variations for Mycosis Fungoides

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Expression for genes affiliated with Mycosis Fungoides

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mycosis Fungoides

Search GEO for disease gene expression data for Mycosis Fungoides.

Pathways for genes affiliated with Mycosis Fungoides

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.7IL2, IL2RB, IL7, CCL22, CCR7, CCR4
2
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10.7CXCL11, CXCL10, CXCL9, IL2RA, IL7, IL2RB
3
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10.7CCL22, CCR7, CCR4, CCL17, CCR3, TNFRSF8
4
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10.6CCR10, CCL17, CCR4, CCR7, CCL22, CCR3
5
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10.6CCL22, CCR7, CCR4, CCL17, CCR10, CCR3
6
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10.6CCL17, CCR4, CCR7, CCL22, CCR10, CCR3
710.6CCL22, CCR7, CCR4, CCL17, CCR10, CCR3
8
Hide members
10.6CCL22, CCR7, CCR4, CCL17, CCR10, CCR3
9
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10.6CCL17, CCR4, CCR7, CCL22, CCR3, ITGAL
10
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10.6CCL22, CCL17, ITGAL, IL2RA, IL7, IL2RB
11
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10.5ITGAL, IL2RA, IL7, IL7, IL2RB, IL2
1210.5ITGAL, CDKN2B, IL2RA, IL2RB, IL2
13
Hide members
10.5CXCR3, CCR3, CCR10, CCR4, CCR7
1410.5ITGAL, CXCR3, CXCL11, CXCL10, CXCL9
15
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10.5IL2, IL2RB, IL2RA, CXCL10
16
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10.5IL2RA, IL7, IL2RB, IL2
17
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10.5IL2RA, IL7, IL2RB, IL2
1810.5IL2, IL2RB, IL7, IL2RA
19
Hide members
10.5IL2, IL2RB, IL7, IL2RA
20
Hide members
10.5IL2, IL2RB, IL2RA, GZMB
2110.5GZMB, IL2RA, IL2RB, IL2
22
Hide members
10.5GZMB, IL2RA, IL2RB, IL2
2310.5GZMB, IL2RA, IL2RB, IL2
2410.5CD1A, CD7, IL2RA, IL7
25
Hide members
10.5IL2, CXCL9, CXCL10, CXCL11
2610.5IL2RA, IL2RB, IL2
27
Hide members
10.5IL2, IL2RB, IL2RA
28
Immune response IL-2 activation and signaling pathway
Hide members
10.5IL2RA, IL2RB, IL2
2910.5IL2RA, IL2RB, IL2
30
Hide members
10.5IL2, IL2RB, IL2RA
31
Hide members
10.5CCR10, GZMB, ITGAL, IL2RA

Compounds for genes affiliated with Mycosis Fungoides

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.1CCR10, CXCL11, IL2RB, IL7, CXCL9, CXCL10
2tacrolimus44 49 1113.1GZMB, IL2, IL2RB, IL7, IL2RA, CXCL10
3tyrosine4411.1ITGAL, CCR3, GZMB, TNFRSF8, IL2, IL2RB
4ccl444 2812.1CCR7, CCL22, CCR4, IL7, CXCL9, CXCL10
5tarc4411.0CXCL9, CCL22, CXCL10, CXCL11, CXCR3, CCR3
6ccl344 2812.0CXCL9, CCR7, CCL22, CCR4, CCL17, CCR3
7rantes4411.0CCR7, GZMB, ITGAL, CXCL11, IL2RA, IL7
8cyclosporin a44 28 5913.0GZMB, TNFRSF8, CCL22, IL2RA, IL7, CXCL11
9histamine44 28 2413.0CXCL10, CXCR3, CCR3, IL2, IL2RB, IL7
10il 104411.0IL2RA, CXCL9, CXCL10, CXCR3, CCL17, IL2RB
11dexamethasone44 49 28 1114.0CCL17, CCR3, GZMB, CXCL11, CXCL9, IL7
12thymidine44 2412.0IL2, IL2RB, IL7, IL2RA, CXCL10, TNFRSF8
13larc4411.0CXCR3, CCR4, CCR7, CCL22, CCL17
14ifn-alpha4411.0CXCL9, CXCR3, IL2RB, CXCL10, IL2, IL2RA
15lipid4411.0IL2RB, IL7, CXCL10, CD1A, ITGAL, TNFRSF8
16azathioprine44 49 2 1114.0IL2RB, IL2RA, CDKN2B, IL2, GZMB, ITGAL
17prednisolone44 28 1113.0CCR4, IL2, GZMB, ITGAL, IL2RA, IL2RB
18cyclophosphamide44 49 1112.9CXCL9, IL2RA, ITGAL, IL7, IL2RB, IL2
19vegf4410.9IL2RA, CXCL10, IL2, CXCR3, GZMB, IL2RB
20ionomycin4410.9IL2, ITGAL, CXCL9, IL2RA, IL7, IL2RB
21neopterin4410.9GZMB, CXCL10, IL2RA, IL2, IL2RB
22basiliximab44 1111.9IL7, IL2RB, IL2RA, IL2
23allergens4410.9ITGAL, CXCL10, CCL17, IL7, CXCR3
24phosphatidylinositol4410.9IL2RB, CCR7, CXCL9, IL7, ITGAL, CXCR3
25leukotriene b444 59 2412.9CCL22, ITGAL, CXCL10, IL7, IL2RB
26nitric oxide44 11 2412.9CCL17, GZMB, ITGAL, IL2RB, IL7, CXCL9
27pge24410.9IL2, ITGAL
28okt34410.9IL2RA, IL7, IL2RB, IL2
29[alcl]4410.9CCR4, CCL17, TNFRSF8, GZMB
30fitc4410.9IL2RA, ITGAL, CCR7, IL2RB
31denileukin diftitox44 49 1112.9IL2RA, IL2RB, IL2
322,5-oligoadenylate4410.9IL2RA, IL2, IL2RB, CXCL10
33ctla4-ig4410.8IL7, IL2RB, IL2
34retinoic acid44 2411.8ITGAL, CDKN2B, IL2RB, CCR3, CCR4, GZMB
35infliximab44 49 1112.8IL2RB, CXCL10, CXCR3, IL2RA
36c-d4t4410.8IL7, IL2, IL2RA
37alpha-galactosylceramide4410.8GZMB, IL2, IL7
38genistein44 28 59 2 11 2415.8CXCL10, IL2RA, IL7, CCR3, IL2RB, IL2
39endotoxin4410.8CXCR3
40daclizumab44 1111.8IL2RB, IL2RA, IL2
41alemtuzumab44 1111.7IL2RA, IL2, IL2RB
42chloroquine44 2 49 28 1114.7ITGAL, IL2RA, CXCL10, IL2
43levamisole44 1111.7IL2RA, IL2RB, IL2
44chromium4410.7IL2RB, GZMB, IL2
45heparin44 28 11 2413.7IL2RA, IL7, CXCR3, GZMB, ITGAL, CCR3
46alanine4410.6CCR7, ITGAL, CXCL10, IL7, GZMB, CCR3
47r-il-24410.5IL2RB, IL2
48ccl282810.5CCR3, CCR10
49mycophenolate4410.4IL2RA, IL2RB
50lentinan4410.2IL2RA, IL2RB

GO Terms for genes affiliated with Mycosis Fungoides

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16Gene Ontology
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Cellular components related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.6IL2RB, CCR7, CCR4, ITGAL, CXCR3, CXCL10
2extracellular spaceGO:00561510.6CCL22, CCL17, CCR3, CXCL11, CXCL10, CXCL9
3integral to plasma membraneGO:00588710.6IL2RB, CXCR3, CD1A, CCR3, CCR10, CCR4
4plasma membraneGO:00588610.5CCR7, CCR4, CCR10, CCR3, TNFRSF8, ITGAL
5extracellular regionGO:00557610.3CCL22, CCL17, CXCL11, CXCL10, CXCL9, IL7

Biological processes related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9IL2, CCL22, CCR7, IL2RA, CXCL9, CXCL10
2chemotaxisGO:00693510.8CXCL9, CXCL10, CXCL11, CXCR3, CCR3, CCR10
3inflammatory responseGO:00695410.8CCL22, CCR7, CCR4, CCL17, CCR3, ITGAL
4elevation of cytosolic calcium ion concentrationGO:00720410.7CCR7, CCR4, CCR10, CCR3, CXCR3, IL2
5cell-cell signalingGO:00726710.7CCL22, CCL17, CXCL11, CXCL10, CXCL9, IL7
6regulation of T cell homeostatic proliferationGO:04601310.6IL2, IL2RA
7signal transductionGO:00716510.6CCL22, TNFRSF8, ITGAL, CXCL11, CXCL10, CXCL9
8G-protein coupled receptor signaling pathwayGO:00718610.5CXCL9, CCR10, CCL17, CCR7
9positive regulation of leukocyte chemotaxisGO:00269010.4CXCL10, CXCL11
10positive regulation of T cell differentiationGO:04558210.2IL2RA, IL7

Molecular functions related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.6CCR3, CCR10, CCR4, CCR7
2chemokine activityGO:00800910.6CCL22, CCL17, CXCL11, CXCL10, CXCL9
3interleukin-2 bindingGO:01997610.5IL2RB, IL2RA
4chemokine receptor activityGO:00495010.4CXCR3, CCR3, CCR4
5interleukin-2 receptor activityGO:00491110.2IL2RB, IL2RA

Products for genes affiliated with Mycosis Fungoides

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Sources for Mycosis Fungoides

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet