MCID: MYC006
MIFTS: 72

Mycosis Fungoides malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Mycosis Fungoides

About this section


NIH Rare Diseases:43 Mycosis fungoides is a disease in which t-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. this condition is one of the most common types of t-cell lymphoma. mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. the rash may last for months or years without causing any symptoms. over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. finally, tumors form which may develop into ulcers and become infected. mycosis fungoides is difficult to cure. treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life. last updated: 1/26/2011

MalaCards based summary: Mycosis Fungoides, also known as mycosis fungoides of unspecified site, is related to cutaneous t cell lymphoma and lymphomatoid papulosis, and has symptoms including eczema, pruritus and lymphoma. An important gene associated with Mycosis Fungoides is CCL17 (chemokine (C-C motif) ligand 17), and among its related pathways are CXCR3-mediated signaling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs cyclophosphamide and etoposide and the compounds ccl19 and etanercept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Genetics Home Reference:23 Mycosis fungoides is the most common form of a type of cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain immune cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Although the skin is involved, the skin cells themselves are not cancerous. Mycosis fungoides usually occurs in adults over age 50, although affected children have been identified.

Wikipedia:65 Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form... more...

Aliases & Classifications for Mycosis Fungoides

About this section

Mycosis Fungoides, Aliases & Descriptions:

Name: Mycosis Fungoides 32 10 43 23 12 45 62
Mycosis Fungoides of Unspecified Site 10 62
Mycosis Fungoides Lymphoma 10 62
Alibert-Bazin Syndrome 43 23
 
Granuloma Fungoides 43 23
Mycosis Fungoides, Unspecified Site, Extranodal and Solid Organ Sites 10
Mycosis Fungoides Nos 10
Mf 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology10 DOID:8691
MeSH35 D009182
NCIt40 C3246
ICD9CM29 202.1
ICD1027 C84.0

Related Diseases for Mycosis Fungoides

About this section

Diseases related to Mycosis Fungoides via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous t cell lymphoma31.4TIA1, CXCL10, CXCR3, CCL17, IL2RB, CDKN2B
2lymphomatoid papulosis31.3CCL17, CXCR3, TIA1
3dermatitis31.0CXCL10, CXCL11, CXCR3, CCL17, CCL22
4psoriasis30.9CXCL10, CXCR3, CXCR1, CCL17, CCR7, CCL22
5leukemia30.8TIA1, CXCR3, CXCR1, CCR7, IL2RB, CD1A
6b-cell lymphomas30.8CDKN2B, CCL17, CXCR3, TIA1
7hodgkin lymphoma30.8TIA1, CCL17, CCL22, IL2RB
8anaplastic large cell lymphoma30.7CXCR3, CCL17, IL2RB
9skin disease30.6CCL17, CXCR1, CXCR3, CXCL11, CXCL10
10atopic dermatitis30.5CCL17, CCL22
11lung cancer30.4CXCL10, CXCR1, CCR7, CDKN2B
12lichen planus30.3CXCL11, CXCR3
13melanoma30.3TIA1, CXCL10, CXCR3, CXCR1, CCR7, IL2RB
14peripheral t-cell lymphoma30.3TIA1, CXCR3, IL2RB
15hepatitis30.3CXCL10, IL2RB
16chronic lymphocytic leukemia30.2CXCR3, CCR7, CDKN2B
17systemic lupus erythematosus30.2CXCL10, CXCR3, CCR7, IL2RB
18uveitis30.2CXCL10, CXCL11, CXCR3, CXCR1
19ulcerative colitis30.2CXCL10, CXCR3, CXCR1, CCL17, CCL22
20folliculotropic mycosis fungoides11.0
21parapsoriasis11.0
22follicular mucinosis10.9
23granuloma annulare10.6
24pityriasis lichenoides10.6
25classical mycosis fungoides10.6
26alopecia10.6
27t-cell leukemia10.6
28adult t-cell leukemia10.5
29acanthosis nigricans10.5
30hematopoietic stem cell transplantation10.5
31xanthomatosis10.5
32myelofibrosis10.4
33leprosy10.4
34hypohidrosis10.4
35composite lymphoma10.4
36lupus erythematosus10.4
37exfoliative dermatitis10.4
38primary cutaneous anaplastic large cell lymphoma10.4
39marfan syndrome10.4
40cutaneous lupus erythematosus10.3
41erysipelas10.3
42folliculitis10.3
43coccidioidomycosis10.3
44dermatophytosis10.3
45eosinophilia10.3
46nephrotic syndrome10.3
47acute myelomonocytic leukemia10.3
48granulomatous slack skin disease10.3
49pigmented purpuric eruption10.3
50localized pagetoid reticulosis10.3

Graphical network of the top 20 diseases related to Mycosis Fungoides:



Diseases related to mycosis fungoides

Symptoms for Mycosis Fungoides

About this section

HPO human phenotypes related to Mycosis Fungoides:

(show all 7)
id Description Frequency HPO Source Accession
1 eczema HP:0000964
2 pruritus HP:0000989
3 lymphoma HP:0002665
4 lymphadenopathy HP:0002716
5 neoplasm of the skin HP:0008069
6 erythema HP:0010783
7 skin plaque HP:0200035

Drugs & Therapeutics for Mycosis Fungoides

About this section

Genetic Tests for Mycosis Fungoides

About this section

Anatomical Context for Mycosis Fungoides

About this section

MalaCards organs/tissues related to Mycosis Fungoides:

33
Skin, T cells, B cells, Bone, Lung, Lymph node, Bone marrow, Thymus, Colon, Testes, Eye, Skeletal muscle, Small intestine, Liver, Pancreas, Breast, Myeloid, Endothelial, Pituitary, Neutrophil

Animal Models for Mycosis Fungoides or affiliated genes

About this section

MGI Mouse Phenotypes related to Mycosis Fungoides:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1CXCL10, CXCR3, CCL17, CCR7, IL2RB, CDKN2B
2MP:00053976.8CDKN2B, TIA1, CXCL10, CXCR3, CCL17, CCR7

Publications for Mycosis Fungoides

About this section

Articles related to Mycosis Fungoides:

(show top 50)    (show all 785)
idTitleAuthorsYear
1
Mycosis fungoides: association of KIR ligands and HLA-DQB1*05 with bad prognosis of the disease. (25753140)
2015
2
Co-existence of various clinical and histopathological features of mycosis fungoides in a young female. (25814741)
2015
3
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. (24131357)
2013
4
Ultraviolet A1 phototherapy for mycosis fungoides. (23082901)
2013
5
Positron emission tomography computed tomography in large cell transformation of mycosis fungoides. (23724793)
2013
6
Epidermotropic marginal zone lymphoma simulating mycosis fungoides(a8 ). (23531038)
2013
7
CD8(+) mycosis fungoides with esophageal involvement: A case report. (23255897)
2013
8
Unilesional Mycosis Fungoides: 3 different clinical presentations. (23830487)
2013
9
Reversible pituitary insufficiency due to bexarotene therapy in a patient with mycosis fungoides. (24068455)
2013
10
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. (23013351)
2013
11
Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. (22542448)
2012
12
Successful treatment of a folliculotropic mycosis fungoides with bexarotene and PUVA. (22240623)
2012
13
Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience. (22044137)
2012
14
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. (22121263)
2011
15
Mycosis fungoides stage IB progressing to cutaneous tumors. (22031631)
2011
16
Flow cytometric evaluation of skin biopsies for mycosis fungoides. (21552102)
2011
17
Simplified flow cytometric assessment in mycosis fungoides and SAczary syndrome. (22095381)
2011
18
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
19
More or less: copy number alterations in mycosis fungoides. (20231832)
2010
20
Free-floating collagen fibers in interstitial mycosis fungoides. (20145533)
2010
21
Immunoelectron microscopy in mycosis fungoides and benign dermatoses. Expression of CD3, CD4 and CD7 receptors. (19895171)
2010
22
Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous Lymphoma. (20128983)
2010
23
Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years. (19583687)
2009
24
Imiquimod in mycosis fungoides. (18424373)
2008
25
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
26
Safety and efficacy of low-dose bexarotene and PUVA in the treatment of patients with mycosis fungoides. (18429646)
2008
27
Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. (18349030)
2008
28
The treatment of unilesional mycosis fungoides with methyl aminolevulinate-photodynamic therapy. (18266688)
2008
29
Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. (18569636)
2008
30
Bexarotene monotherapy for patients with refractory early stage mycosis fungoides. (18405191)
2008
31
TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. (18204745)
2007
32
Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome. (17975162)
2007
33
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
34
Folliculotropic mycosis fungoides with CD30+ large-cell transformation in a young woman: beneficial effect of bexarotene. (17300259)
2007
35
Abnormal expression of interleukin-23 in mycosis fungoides/SAczary syndrome lesions. (17021762)
2006
36
Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. (16675558)
2006
37
Folliculotropic mycosis fungoides with central nervous system involvement: demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection. (12582395)
2003
38
p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides. (11850526)
2002
39
Cytokine profile of patients with mycosis fungoides and the immunomodulatory effect of AS101. (11720171)
2001
40
Alteration of cytokine genes and bcl-2 expression following immunotherapy with intralesional IFN-gamma in a patient with tumor-stage mycosis fungoides. (9621132)
1998
41
Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis? (9650701)
1998
42
Granulomatous mycosis fungoides with small intestinal involvement and a fatal outcome. (9580813)
1998
43
Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease. (7887663)
1995
44
Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells. (1731519)
1992
45
A case of classical mycosis fungoides associated with human T-cell lymphotropic virus type I. (2004007)
1991
46
Widespread eczematous dermatitis with erythematous facial plaques. Alopecia mucinosa (follicular mucinosis [FM]) with possible mycosis fungoides (MF). (1832536)
1991
47
Treatment of a case of mycosis fungoides and one of parapsoriasis en plaque with topical PUVA using a monofunctional furocoumarin derivative, 4,6,4'-trimethylangelicin. (2277144)
1990
48
Plutonium-induced mycosis fungoides and parapsoriasis en plaques--a new entity? (2298035)
1990
49
Follicular mucinosis, mycosis fungoides, and acute myeloid leukemia. (2341572)
1990
50
Depressed lymphokine activated killer cell activity in mycosis fungoides. A possible marker for aggressive disease. (2360838)
1990

Variations for Mycosis Fungoides

About this section

Cosmic variations for Mycosis Fungoides:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1532KRAShaematopoietic and lymphoid tissue,skin,lymphoid neoplasm,cutaneous T cell lymphoma1

Expression for genes affiliated with Mycosis Fungoides

About this section

Search GEO for disease gene expression data for Mycosis Fungoides.

Pathways for genes affiliated with Mycosis Fungoides

About this section

Pathways related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCL10, CXCL11, CXCR3
2
Show member pathways
Peptide GPCRs38
9.2CCR7, CXCR1, CXCR3
3
Show member pathways
8.3CXCL10, CXCL11, CXCR3, CCL17, CCR7, CCL22
4
Show member pathways
7.9CCL22, CCR7, CCL17, CXCR3, CXCL11, CXCL10
5
Show member pathways
7.9CXCL10, IL2RB, CCL22, CCR7, CCL17, CXCR3
6
Show member pathways
7.8CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
7
Show member pathways
7.8CCL22, CXCL10, CXCL11, CXCR3, CXCR1, CCL17
8
Show member pathways
7.8CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
9
Show member pathways
7.4CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
10
Show member pathways
7.1CXCL10, CXCL11, CXCR3, CCL17, CCR7, CCL22
11
Show member pathways
6.9CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7

Compounds for genes affiliated with Mycosis Fungoides

About this section

Compounds related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1ccl193010.1CXCR3, CCR7
2etanercept45 51 1312.0IL2RB, CXCR3
3methacholine45 51 1311.9IL2RB, CCL22
4[alcl]459.8CCL17, TIA1
52,5-oligoadenylate459.8CXCL10, IL2RB
6allergens459.7CCL17, CXCR3, CXCL10
7infliximab45 51 1311.6IL2RB, CXCR3, CXCL10
8ifn-alpha459.6IL2RB, CXCR3, CXCL10
9larc459.6CXCR3, CCL17, CCR7, CCL22
10fitc459.5CXCR1, CCR7, IL2RB
11ribavirin45 51 1311.5CXCR3, CXCL10
12groalpha459.5CXCR1, CXCR3, CXCL10
13cyclosporin a45 30 6111.5CXCL11, CCL17, CCL22, IL2RB
14matrigel459.5CXCL10, CXCR3, CCR7
15il 10459.4CXCL10, CXCR3, CCL17, IL2RB
16neopterin459.3IL2RB, CXCL10
17histamine45 30 2611.3CXCL10, CXCR3, CCL22, IL2RB
18superoxide45 2610.3IL2RB, CXCR1, CXCR3
19wortmannin459.3CXCL10, CXCR3, CXCR1
20nitric oxide45 26 1311.2IL2RB, CCL17, CXCR3, CXCL10
21progesterone45 30 61 26 1313.2CXCL10, CXCL11, CXCR3, IL2RB
22leukotriene b445 61 2611.1CXCL10, CXCR1, CCL22, IL2RB
23endotoxin459.1CXCL10, CXCR3, CXCR1, IL2RB
24genistein45 30 61 3 26 1314.1CXCL10, CXCR1, IL2RB
25vegf459.0IL2RB, CXCR1, CXCR3, CXCL10
26pge2458.9CXCL10, CXCR3, CCR7, CCL22, IL2RB
27ccl445 309.7CXCL10, CXCL11, CXCR3, CCL17, CCR7, CCL22
28tacrolimus45 51 1310.7CXCL10, CXCR3, CCL17, CCR7, CCL22, IL2RB
29phosphatidylinositol458.7CXCL10, CXCR3, CXCR1, CCR7, IL2RB
30lipid458.5CD1A, IL2RB, CCR7, CXCR1, CXCL10
31retinoic acid45 269.3CDKN2B, IL2RB, CXCR1, CXCL10
32dexamethasone45 51 30 1311.2CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCL22
33ccl345 309.2CCL22, CXCL10, CCR7, CCL17, CXCR1, CXCR3
34tarc458.2CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
35tyrosine457.8CXCL10, CXCR3, CXCR1, CCR7, IL2RB, CDKN2B
36rantes457.8CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7
37calcium45 51 26 1310.8CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7

GO Terms for genes affiliated with Mycosis Fungoides

About this section

Cellular components related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056159.0CCL22, CCL17, CXCL11, CXCL10
2external side of plasma membraneGO:00098978.5IL2RB, CCR7, CXCR3, CXCL10

Biological processes related to Mycosis Fungoides according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell chemotaxisGO:00603269.8CCL17, CCL22
2negative regulation of angiogenesisGO:00165259.6CXCR3, CXCL10
3dendritic cell chemotaxisGO:00024079.6CCR7, CXCR1
4positive regulation of cAMP metabolic processGO:00308169.5CXCR3, CXCL11, CXCL10
5T cell chemotaxisGO:00108189.5CXCL10, CXCL11, CXCR3
6positive regulation of cAMP-mediated signalingGO:00439509.5CXCR3, CXCL11, CXCL10
7positive regulation of release of sequestered calcium ion into cytosolGO:00512819.4CXCR3, CXCL11, CXCL10
8cell-cell signalingGO:00072679.1CXCL10, CXCL11, CCL17, CCL22
9cell surface receptor signaling pathwayGO:00071669.1CXCR1, CXCR3, CXCL10
10chemokine-mediated signaling pathwayGO:00700988.9CXCL10, CXCL11, CXCR1, CCR7
11signal transductionGO:00071658.6IL2RB, CCL22, CXCL11, CXCL10
12G-protein coupled receptor signaling pathwayGO:00071868.6CXCL10, CXCR3, CXCR1, CCL17, CCR7
13chemotaxisGO:00069358.5CCL22, CCL17, CXCR1, CXCR3, CXCL11, CXCL10
14immune responseGO:00069558.4CXCL10, CXCL11, CCL17, CCR7, CCL22, CD1A
15inflammatory responseGO:00069548.1CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7

Molecular functions related to Mycosis Fungoides according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.6CXCR1, CXCR3
2CXCR3 chemokine receptor bindingGO:00482489.3CXCL11, CXCL10
3chemokine activityGO:00080098.9CCL22, CCL17, CXCL11, CXCL10

Products for genes affiliated with Mycosis Fungoides

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Mycosis Fungoides

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet