MCID: MYC006
MIFTS: 62

Mycosis Fungoides malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Mycosis Fungoides

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Aliases & Descriptions for Mycosis Fungoides:

Name: Mycosis Fungoides 30 8 42 21 10 44 61
Alibert-Bazin Syndrome 42 21
Granuloma Fungoides 42 21
Mycosis Fungoides, Unspecified Site, Extranodal and Solid Organ Sites 8
 
Mycosis Fungoides of Unspecified Site 8
Mycosis Fungoides Lymphoma 8
Mycosis Fungoides Nos 8
Mf 8


Classifications:



External Ids:

Disease Ontology8 DOID:8691
MeSH33 D009182
NCIt39 C3246
ICD9CM27 202.1
ICD1025 C84.0

Summaries for Mycosis Fungoides

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NIH Rare Diseases:42 Mycosis fungoides is a disease in which t-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. this condition is one of the most common types of t-cell lymphoma. mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. the rash may last for months or years without causing any symptoms. over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. finally, tumors form which may develop into ulcers and become infected. mycosis fungoides is difficult to cure. treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life. last updated: 1/26/2011

MalaCards based summary: Mycosis Fungoides, also known as alibert-bazin syndrome, is related to lymphomatoid papulosis and anaplastic large cell lymphoma, and has symptoms including eczema, pruritus and lymphoma. An important gene associated with Mycosis Fungoides is CCL17 (chemokine (C-C motif) ligand 17), and among its related pathways are CXCR3-mediated signaling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The drugs methotrexate and methotrexate sodium and the compounds ccl19 and etanercept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Genetics Home Reference:21 Mycosis fungoides is the most common form of a type of cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain immune cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Although the skin is involved, the skin cells themselves are not cancerous. Mycosis fungoides usually occurs in adults over age 50, although affected children have been identified.

Wikipedia:64 Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form... more...

Related Diseases for Mycosis Fungoides

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Diseases related to Mycosis Fungoides via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1lymphomatoid papulosis31.5CCL17, TIA1, CXCR3
2anaplastic large cell lymphoma30.9CCL17, IL2RB, CXCR3
3dermatitis30.8CXCL11, CCL22, CXCR3, CCL17, CXCL10
4atopic dermatitis30.8CCL17, CCL22
5hodgkin lymphoma30.7TIA1, CCL22, IL2RB, CCL17
6lichen planus30.7CXCL11, CXCR3
7cutaneous t cell lymphoma30.6CDKN2B, TIA1, CXCL10, CXCR3, CCL17, IL2RB
8b-cell lymphomas30.5TIA1, CCL17, CXCR3, CDKN2B
9psoriasis30.4CCL17, CXCL10, CCR7, CCL22, CXCR1, CXCR3
10peripheral t-cell lymphoma30.4CXCR3, IL2RB, TIA1
11hepatitis30.4CXCL10, IL2RB
12skin disease30.3CCL17, CXCR3, CXCL11, CXCL10, CXCR1
13chronic lymphocytic leukemia30.2CXCR3, CCR7, CDKN2B
14systemic lupus erythematosus30.1CXCL10, IL2RB, CCR7, CXCR3
15uveitis30.1CXCL11, CXCR3, CXCR1, CXCL10
16ulcerative colitis30.0CCL17, CCL22, CXCL10, CXCR1, CXCR3
17lung cancer29.9CXCL10, CXCR1, CCR7, CDKN2B
18leukemia29.7IL2RB, CDKN2B, CD1A, TIA1, CCR7, CXCR3
19melanoma28.8CD1A, IL2RB, CCR7, TIA1, CXCR1, CXCL10
20folliculotropic mycosis fungoides11.0
21parapsoriasis10.9
22follicular mucinosis10.9
23granuloma annulare10.6
24pityriasis lichenoides10.6
25classical mycosis fungoides10.6
26alopecia10.6
27t-cell leukemia10.6
28adult t-cell leukemia10.5
29acanthosis nigricans10.5
30paragonimiasis10.5CCL17
31malaria10.5IL2RB
32hematopoietic stem cell transplantation10.5
33xanthomatosis10.5
34myelofibrosis10.4
35leprosy10.4
36hypohidrosis10.4
37composite lymphoma10.4
38lupus erythematosus10.4
39exfoliative dermatitis10.4
40primary cutaneous anaplastic large cell lymphoma10.4
41eosinophilic pneumonia10.4CCL17, CCL22
42marfan syndrome10.4
43cutaneous lupus erythematosus10.3
44erysipelas10.3
45folliculitis10.3
46coccidioidomycosis10.3
47dermatophytosis10.3
48eosinophilia10.3
49nephrotic syndrome10.3
50acute myelomonocytic leukemia10.3

Graphical network of the top 20 diseases related to Mycosis Fungoides:



Diseases related to mycosis fungoides

Symptoms for Mycosis Fungoides

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HPO human phenotypes related to Mycosis Fungoides:

(show all 7)
id Description Frequency HPO Source Accession
1 eczema HP:0000964
2 pruritus HP:0000989
3 lymphoma HP:0002665
4 lymphadenopathy HP:0002716
5 neoplasm of the skin HP:0008069
6 erythema HP:0010783
7 skin plaque HP:0200035

Drugs & Therapeutics for Mycosis Fungoides

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Valchlor13 MECHLORETHAMINE HYDROCHLORIDE Ceptaris Therapeutics Approved August 2013
FDA Label: Valchlor
Malady that Drug Treats: Stage IA/IB mycosisfungoides-type cutaneous T-cell lymphoma
Indications and Usage:13 VALCHLOR is an alkylating drug indicated for the topical treatment; of Stage IA and IB mycosis fungoides type cutaneous T cell; lymphoma in patients who have received prior skin directed therapy; (1).  
DrugBank Targets:11 1. DNA
Mechanism of Action:13 
Target: rapidly-proliferating cells
Action: inhibitor
FDA: Mechlorethamine, also known as nitrogen mustard, is an alkylating agent which inhibits rapidly proliferating cells.

Drug clinical trials:

Search ClinicalTrials for Mycosis Fungoides

Search NIH Clinical Center for Mycosis Fungoides

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Mycosis Fungoides cell therapies at LifeMap Discovery.

Genetic Tests for Mycosis Fungoides

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Anatomical Context for Mycosis Fungoides

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MalaCards organs/tissues related to Mycosis Fungoides:

31
Skin, T cells, B cells, Bone, Lung, Lymph node, Bone marrow, Thymus, Colon, Testes, Eye, Skeletal muscle, Small intestine, Liver, Pancreas, Breast, Myeloid, Endothelial, Pituitary, Neutrophil

Animal Models for Mycosis Fungoides or affiliated genes

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MGI Mouse Phenotypes related to Mycosis Fungoides:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1CXCL10, CXCR3, CCL17, CCR7, IL2RB, CDKN2B
2MP:00053976.8CDKN2B, TIA1, CXCL10, CXCR3, CCL17, CCR7

Publications for Mycosis Fungoides

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Articles related to Mycosis Fungoides:

(show top 50)    (show all 785)
idTitleAuthorsYear
1
Mycosis fungoides: association of KIR ligands and HLA-DQB1*05 with bad prognosis of the disease. (25753140)
2015
2
Co-existence of various clinical and histopathological features of mycosis fungoides in a young female. (25814741)
2015
3
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. (24131357)
2013
4
Ultraviolet A1 phototherapy for mycosis fungoides. (23082901)
2013
5
Positron emission tomography computed tomography in large cell transformation of mycosis fungoides. (23724793)
2013
6
Epidermotropic marginal zone lymphoma simulating mycosis fungoides(a8 ). (23531038)
2013
7
CD8(+) mycosis fungoides with esophageal involvement: A case report. (23255897)
2013
8
Unilesional Mycosis Fungoides: 3 different clinical presentations. (23830487)
2013
9
Reversible pituitary insufficiency due to bexarotene therapy in a patient with mycosis fungoides. (24068455)
2013
10
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. (23013351)
2013
11
Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. (22542448)
2012
12
Successful treatment of a folliculotropic mycosis fungoides with bexarotene and PUVA. (22240623)
2012
13
Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience. (22044137)
2012
14
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. (22121263)
2011
15
Mycosis fungoides stage IB progressing to cutaneous tumors. (22031631)
2011
16
Flow cytometric evaluation of skin biopsies for mycosis fungoides. (21552102)
2011
17
Simplified flow cytometric assessment in mycosis fungoides and SAczary syndrome. (22095381)
2011
18
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
19
More or less: copy number alterations in mycosis fungoides. (20231832)
2010
20
Free-floating collagen fibers in interstitial mycosis fungoides. (20145533)
2010
21
Immunoelectron microscopy in mycosis fungoides and benign dermatoses. Expression of CD3, CD4 and CD7 receptors. (19895171)
2010
22
Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous Lymphoma. (20128983)
2010
23
Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years. (19583687)
2009
24
Imiquimod in mycosis fungoides. (18424373)
2008
25
Fatal outcome due to bacterial superinfection of eczema herpeticum in a patient with mycosis fungoides. (18713601)
2008
26
Safety and efficacy of low-dose bexarotene and PUVA in the treatment of patients with mycosis fungoides. (18429646)
2008
27
Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. (18349030)
2008
28
The treatment of unilesional mycosis fungoides with methyl aminolevulinate-photodynamic therapy. (18266688)
2008
29
Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. (18569636)
2008
30
Bexarotene monotherapy for patients with refractory early stage mycosis fungoides. (18405191)
2008
31
TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. (18204745)
2007
32
Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome. (17975162)
2007
33
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
34
Folliculotropic mycosis fungoides with CD30+ large-cell transformation in a young woman: beneficial effect of bexarotene. (17300259)
2007
35
Abnormal expression of interleukin-23 in mycosis fungoides/SAczary syndrome lesions. (17021762)
2006
36
Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. (16675558)
2006
37
Folliculotropic mycosis fungoides with central nervous system involvement: demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection. (12582395)
2003
38
p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides. (11850526)
2002
39
Cytokine profile of patients with mycosis fungoides and the immunomodulatory effect of AS101. (11720171)
2001
40
Alteration of cytokine genes and bcl-2 expression following immunotherapy with intralesional IFN-gamma in a patient with tumor-stage mycosis fungoides. (9621132)
1998
41
Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis? (9650701)
1998
42
Granulomatous mycosis fungoides with small intestinal involvement and a fatal outcome. (9580813)
1998
43
Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease. (7887663)
1995
44
Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells. (1731519)
1992
45
A case of classical mycosis fungoides associated with human T-cell lymphotropic virus type I. (2004007)
1991
46
Widespread eczematous dermatitis with erythematous facial plaques. Alopecia mucinosa (follicular mucinosis [FM]) with possible mycosis fungoides (MF). (1832536)
1991
47
Treatment of a case of mycosis fungoides and one of parapsoriasis en plaque with topical PUVA using a monofunctional furocoumarin derivative, 4,6,4'-trimethylangelicin. (2277144)
1990
48
Plutonium-induced mycosis fungoides and parapsoriasis en plaques--a new entity? (2298035)
1990
49
Follicular mucinosis, mycosis fungoides, and acute myeloid leukemia. (2341572)
1990
50
Depressed lymphokine activated killer cell activity in mycosis fungoides. A possible marker for aggressive disease. (2360838)
1990

Variations for Mycosis Fungoides

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Cosmic variations for Mycosis Fungoides:

6
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1532KRAShaematopoietic and lymphoid tissue,skin,lymphoid neoplasm,cutaneous T cell lymphoma1

Expression for genes affiliated with Mycosis Fungoides

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Search GEO for disease gene expression data for Mycosis Fungoides.

Pathways for genes affiliated with Mycosis Fungoides

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Pathways related to Mycosis Fungoides according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCL10, CXCL11, CXCR3
2
Show member pathways
8.3CCL22, CXCL10, CXCL11, CXCR3, CCL17, CCR7
3
Show member pathways
7.9CXCL10, CXCL11, CXCR3, CCL17, CCR7, IL2RB
4
Show member pathways
7.9CCL22, IL2RB, CXCL10, CXCL11, CXCR3, CCR7
5
Show member pathways
7.8CCL17, CXCL10, CXCL11, CXCR3, CXCR1, CCL22
6
Show member pathways
7.8CXCR1, CCR7, CXCR3, CXCL11, CXCL10, CCL22
7
Show member pathways
7.8CXCL10, CXCR1, CCL22, CXCL11, CXCR3, CCL17
8
Show member pathways
7.4IL2RB, CCL22, CCR7, CCL17, CXCR1, CXCR3
9
Show member pathways
7.1CXCL10, CXCL11, CDKN2B, IL2RB, CCL22, CCR7
10
Show member pathways
6.9CXCR3, CXCL11, CXCL10, CXCR1, CCR7, CCL17

Compounds for genes affiliated with Mycosis Fungoides

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Compounds related to Mycosis Fungoides according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1ccl192810.1CXCR3, CCR7
2etanercept44 50 1112.0CXCR3, IL2RB
3methacholine44 50 1111.9CCL22, IL2RB
4[alcl]449.8TIA1, CCL17
52,5-oligoadenylate449.8CXCL10, IL2RB
6allergens449.7CXCL10, CXCR3, CCL17
7infliximab44 50 1111.6CXCR3, CXCL10, IL2RB
8ifn-alpha449.6IL2RB, CXCR3, CXCL10
9larc449.6CCL22, CXCR3, CCL17, CCR7
10fitc449.5CCR7, CXCR1, IL2RB
11ribavirin44 50 1111.5CXCR3, CXCL10
12groalpha449.5CXCL10, CXCR1, CXCR3
13cyclosporin a44 28 6011.5IL2RB, CCL22, CXCL11, CCL17
14matrigel449.5CXCR3, CXCL10, CCR7
15il 10449.4CXCL10, CXCR3, CCL17, IL2RB
16neopterin449.3CXCL10, IL2RB
17histamine44 28 2411.3CXCR3, CCL22, CXCL10, IL2RB
18wortmannin449.3CXCR1, CXCR3, CXCL10
19superoxide44 2410.3IL2RB, CXCR1, CXCR3
20nitric oxide44 24 1111.2IL2RB, CCL17, CXCL10, CXCR3
21progesterone44 28 60 24 1113.2CXCR3, CXCL10, CXCL11, IL2RB
22leukotriene b444 60 2411.1CXCR1, CCL22, CXCL10, IL2RB
23endotoxin449.1IL2RB, CXCR3, CXCL10, CXCR1
24genistein44 28 60 1 24 1114.1CXCL10, IL2RB, CXCR1
25vegf449.0IL2RB, CXCL10, CXCR1, CXCR3
26pge2448.9CCR7, CXCR3, CXCL10, CCL22, IL2RB
27ccl444 289.7CCR7, CXCL10, CXCL11, CCL17, CXCR3, CCL22
28tacrolimus44 50 1110.7CXCL10, CXCR3, IL2RB, CCL22, CCR7, CCL17
29phosphatidylinositol448.7CXCR3, CXCL10, IL2RB, CXCR1, CCR7
30lipid448.5CCR7, CXCR1, IL2RB, CXCL10, CD1A
31retinoic acid44 249.3IL2RB, CDKN2B, CXCL10, CXCR1
32dexamethasone44 50 28 1111.2CCL17, CXCR1, IL2RB, CXCR3, CCL22, CXCL10
33tarc448.2CXCL10, CCL17, CCL22, CCR7, CXCR1, CXCR3
34ccl344 289.2CCL22, CCR7, CCL17, CXCR1, CXCR3, CXCL11
35tyrosine447.8CDKN2B, CXCL10, CXCR3, CCR7, IL2RB, CXCR1
36rantes447.8CXCR3, CXCR1, CCL17, CCR7, CCL22, IL2RB
37calcium44 50 24 1110.8IL2RB, CXCL11, CCL22, CCR7, CCL17, CXCL10

GO Terms for genes affiliated with Mycosis Fungoides

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Cellular components related to Mycosis Fungoides according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056159.0CCL22, CCL17, CXCL11, CXCL10
2external side of plasma membraneGO:00098978.5IL2RB, CCR7, CXCR3, CXCL10

Biological processes related to Mycosis Fungoides according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cell chemotaxisGO:00603269.8CCL17, CCL22
2negative regulation of angiogenesisGO:00165259.6CXCR3, CXCL10
3dendritic cell chemotaxisGO:00024079.6CCR7, CXCR1
4positive regulation of cAMP metabolic processGO:00308169.5CXCR3, CXCL11, CXCL10
5T cell chemotaxisGO:00108189.5CXCL10, CXCL11, CXCR3
6positive regulation of cAMP-mediated signalingGO:00439509.5CXCR3, CXCL11, CXCL10
7positive regulation of release of sequestered calcium ion into cytosolGO:00512819.4CXCR3, CXCL11, CXCL10
8cell-cell signalingGO:00072679.1CXCL10, CXCL11, CCL17, CCL22
9cell surface receptor signaling pathwayGO:00071669.1CXCR1, CXCR3, CXCL10
10chemokine-mediated signaling pathwayGO:00700988.9CXCL10, CXCL11, CXCR1, CCR7
11signal transductionGO:00071658.6IL2RB, CCL22, CXCL11, CXCL10
12G-protein coupled receptor signaling pathwayGO:00071868.6CXCL10, CXCR3, CXCR1, CCL17, CCR7
13chemotaxisGO:00069358.5CCL22, CCL17, CXCR1, CXCR3, CXCL11, CXCL10
14immune responseGO:00069558.4CXCL10, CXCL11, CCL17, CCR7, CCL22, CD1A
15inflammatory responseGO:00069548.1CXCL10, CXCL11, CXCR3, CXCR1, CCL17, CCR7

Molecular functions related to Mycosis Fungoides according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.6CXCR1, CXCR3
2CXCR3 chemokine receptor bindingGO:00482489.3CXCL11, CXCL10
3chemokine activityGO:00080098.9CCL22, CCL17, CXCL11, CXCL10

Sources for Mycosis Fungoides

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet