Aliases & Classifications for Myelitis

About this section

Myelitis, Aliases & Descriptions:

Name: Myelitis 9 41 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:322
NCIt38 C26832
MeSH33 D009187

Summaries for Myelitis

About this section


Wikipedia:63 Myelitis involves the infection or the inflammation of the white matter or gray matter of the spinal... more...

MalaCards based summary: Myelitis is related to transverse myelitis and neuromyelitis optica. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Arf6 signaling events and Integrin alphaIIb beta3 signaling. The compounds sandoglobulin and hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are renal/urinary system and respiratory system.

Related Diseases for Myelitis

About this section

Diseases related to Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1transverse myelitis32.3MBP, AQP4, APOH
2neuromyelitis optica31.5AQP4, MBP
3neuritis31.4MBP
4optic neuritis31.3MBP, AQP4
5acute disseminated encephalomyelitis31.1MBP, AQP4
6rubella31.0CD40LG
7encephalitis30.9AMPH, MBP, IL17A, AQP4
8lyme disease30.8CD40LG, MBP
9measles30.8CD40LG, MBP
10syphilis30.8APOH
11toxoplasmosis30.7CD40LG
12pneumonia30.7IL6, CCL11, IL17A
13vasculitis30.6APOH, IL17A, CD40LG
14antiphospholipid syndrome30.6APOH, CD40LG, MTHFR
15demyelinating disease30.6IL17A, MBP, AQP4
16polyneuropathy30.6MBP, CD40LG
17scrub typhus30.5CD40LG
18arthritis30.5IL17A, IL6
19tetanus30.5CD27, MBP, CD40LG
20common variable immunodeficiency30.5CD27, CD40LG
21myasthenia gravis30.4MBP, HLA-DPB1
22guillain-barre syndrome30.4CD40LG, MBP
23systemic lupus erythematosus30.4IL17A, HLA-DPB1, IL6, APOH, CD40LG, CD27
24connective tissue disease30.2APOH, CD40LG, IL6
25nephritis30.2IL17A, APOH, CD40LG
26lupus nephritis30.1APOH, CD40LG
27paraneoplastic syndromes30.0AMPH, IL6
28ulcerative colitis29.7IL17A, IL6, CCL11
29congenital heart disease29.6MTHFR, CD40LG, IL6
30myocardial infarction29.5CCL11, ITGA2B, ITGB3, MTHFR
31breast cancer29.4MBP, IL17A, ITGB3, MTHFR, AMPH, CCL11
32psoriasis29.3CCL11, IL17A, IL6
33rheumatoid arthritis28.4ITGB3, MTHFR, CCL11, APOH, HLA-DPB1, CD27
34leukemia28.3IL6, MBP, CD27, CD40LG, ITGA2B, CCL11
35acute transverse myelitis11.0
36lupus erythematosus10.7
37radiation myelitis10.6
38retinal artery occlusion10.6APOH
39hemorrhagic fever10.5CD40LG
40thrombophlebitis10.5APOH
41cervicitis10.5
42limbic encephalitis10.5AMPH
43idiopathic acute transverse myelitis10.5
44hepatitis10.5
45bronchiolitis10.4CCL11
46cryoglobulinemia10.4CD40LG, APOH
47meningitis10.4
48neuropathy10.4
49eclampsia10.3MTHFR
50spondyloarthropathy 110.3CD40LG, IL17A

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to myelitis

Symptoms for Myelitis

About this section

Drugs & Therapeutics for Myelitis

About this section

Drug clinical trials:

Search ClinicalTrials for Myelitis

Search NIH Clinical Center for Myelitis

Genetic Tests for Myelitis

About this section

Anatomical Context for Myelitis

About this section

MalaCards organs/tissues related to Myelitis:

31
Spinal cord, Brain, Bone, Bone marrow, Lung, Kidney, Breast, Heart, Colon, Pancreas, Salivary gland, Skin, Testes, Cervix, Myeloid, Nk cells, T cells, B cells, Medulla oblongata

Animal Models for Myelitis or affiliated genes

About this section

Publications for Myelitis

About this section

Articles related to Myelitis:

(show top 50)    (show all 797)
idTitleAuthorsYear
1
Acute idiopathic transverse myelitis in children: early predictors of relapse and disability. (25540303)
2015
2
Longitudinally extensive transverse myelitis in systemic lupus erythematosus: case report and review of the literature. (25544684)
2015
3
Predictors of recurrence following an initial episode of transverse myelitis. (25340060)
2014
4
Transverse myelitis associated with an itchy rash and hyperckemia: neuromyelitis optica associated with dermatitis herpetiformis. (24637913)
2014
5
An acute transverse myelitis attack after total body irradiation: a rare case. (23984124)
2013
6
Extensive myelitis associated with anti-NMDA receptor antibodies. (24373538)
2013
7
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
8
Pulse-triggered DTI sequence with reduced FOV and coronal acquisition at 3T for the assessment of the cervical spinal cord in patients with myelitis. (22918433)
2013
9
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
10
Human herpes virus 6-associated myelitis following allogeneic bone marrow transplantation. (22415068)
2012
11
Diagnosis and treatment of pediatric acute transverse myelitis. (23814937)
2012
12
Zoster myelitis in sickle cell anemia. (22246022)
2012
13
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
14
Stiff leg syndrome and myelitis with anti-amphiphysin antibodies: a common physiopathology? (21986240)
2011
15
Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis. (21523924)
2011
16
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
17
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
18
Mycoplasma pneumoniae--associated transverse myelitis and rhabdomyolysis. (19135630)
2009
19
Verminous myelitis in a pit bull puppy. (19407100)
2009
20
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
21
Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient. (18810606)
2008
22
A case of anti-aquaporin-4 and anti-glutamate receptor antibodies positive myelitis presented with modest clinical signs. (18460850)
2008
23
Evidence for a causal association between oral polio vaccine and transverse myelitis: A case history and review of the Literature. (16630313)
2006
24
Transverse myelitis following general and epidural anaesthesia in a paediatric patient. (16115254)
2005
25
Acute transverse myelitis and hepatitis C virus. (15888983)
2005
26
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
27
Recurrent transverse myelitis following neurobrucellosis: immunologic features and beneficial response to immunosuppression. (16036801)
2005
28
Percutaneous embolisation and transverse myelitis: a rare association. (15366806)
2004
29
Anterior horn cell involvement in myelitis with atopic diathesis (atopic myelitis). (15101198)
2004
30
Transverse myelitis occurring in association with primary biliary cirrhosis and Sjogren's syndrome. (12741480)
2003
31
Multiphasic demyelinating disorder with acute transverse myelitis in Japanese. (12814118)
2003
32
Necrotizing myelitis in an immunocompetent child: a case report with review of literature. (14701948)
2003
33
Non-progressive viral myelitis in X-linked agammaglobulinemia. (11891104)
2002
34
Acute transverse myelitis after Japanese B encephalitis vaccination in a 4-year-old girl. (11934518)
2002
35
Transverse myelitis associated with herpes simplex virus infection. (11732777)
2001
36
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
37
Efficacy of high dose steroid therapy in children with severe acute transverse myelitis. (11459911)
2001
38
Decrease in multiple sclerosis with acute transverse myelitis in Japan. (10494904)
1999
39
MR imaging of acute transverse myelitis. (10224833)
1999
40
Acute transverse myelitis due to spinal epidural hematoma-first manifestation of severe hemophilia. (10745339)
1999
41
Absence of thoracic radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for Stage III nonsmall-cell lung cancer. (9457819)
1998
42
A case of acute transverse myelitis affecting the entire length of the spinal cord. (9208267)
1997
43
Postural hypotension in a patient with acute myelitis. (8731714)
1996
44
Accelerated treatment and radiation myelitis. (1902318)
1991
45
Local stem cell depletion model for radiation myelitis. (3384725)
1988
46
Hyperbaric oxygen therapy for radiation myelitis. (4082347)
1985
47
Transverse myelitis due to meningovascular syphilis. (6696656)
1984
48
Leads from the MMWR. Acute schistosomiasis with transverse myelitis in American students returning from Kenya. (6471329)
1984
49
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
50
Syphilitic Meningo-Myelitis: Erysipelas: Recovery. (20759725)
1901

Variations for Myelitis

About this section

Expression for genes affiliated with Myelitis

About this section
Search GEO for disease gene expression data for Myelitis.

Pathways for genes affiliated with Myelitis

About this section

Pathways related to Myelitis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, ITGA2B
2
Show member pathways
9.7ITGA2B, ITGB3
39.7ITGA2B, ITGB3
49.7ITGA2B, ITGB3
59.6IL6, CCL11
6
Show member pathways
Serotonin Transporter Activity36
9.5ITGB3, AMPH
79.4CD40LG, ITGB3, CCL11
8
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.4CD40LG, IL6, IL17A
99.3HLA-DPB1, IL17A, IL6
10
Show member pathways
9.2HLA-DPB1, CD27, CD40LG
11
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.2IL6, ITGA2B, ITGB3
129.2IL6, ITGA2B, ITGB3
13
Show member pathways
9.2ITGA2B, ITGB3, AMPH
14
Show member pathways
9.0CD40LG, IL6, IL17A, HLA-DPB1
15
Show member pathways
9.0HLA-DPB1, CCL11, IL6, CD40LG
168.9MBP, IL6, AQP4
17
Show member pathways
8.9CCL11, ITGB3, ITGA2B, IL6
18
Show member pathways
8.9CCL11, ITGB3, ITGA2B, IL6
19
Show member pathways
8.4CCL11, IL17A, IL6, CD27, CD40LG

Compounds for genes affiliated with Myelitis

About this section

Compounds related to Myelitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1sandoglobulin4310.0CD40LG, IL6
2hydroxychloroquine43 1211.0APOH, CD40LG
3bio 12115910.0ITGA2B, ITGB3
4obtustatin5910.0ITGB3, ITGA2B
5tc-i 155910.0ITGA2B, ITGB3
6a 2869825910.0ITGA2B, ITGB3
7leukadherin 15910.0ITGA2B, ITGB3
8tirofiban43 1210.8ITGA2B, ITGB3, CD40LG
9abciximab43 1210.8ITGB3, ITGA2B, CD40LG
10vitamin b12439.8CD40LG, APOH, MTHFR
11etanercept43 49 1211.8APOH, IL17A, IL6
12infliximab43 49 1211.8IL6, APOH, IL17A
13groalpha439.8IL17A, CCL11, IL6
14dextran sulfate439.7CD40LG, APOH, IL6
15rituximab43 49 1211.7APOH, IL6, CD40LG
16p002439.7APOH, IL17A, MTHFR
17sele439.6MTHFR, ITGB3
18pravastatin43 49 28 24 1213.4IL6, CD40LG, MTHFR
19rantes439.4IL6, CD40LG, IL17A, CCL11
20methacholine43 49 1211.4CCL11, MBP, IL17A
21histamine43 28 2411.4AQP4, CCL11, CD40LG, IL6
22hyaluronic acid43 2410.3CCL11, IL6, CD40LG
23actinomycin d439.3IL6, IL17A, CCL11, CD40LG
24endotoxin439.2CCL11, IL17A, IL6, CD40LG, APOH
25pge2439.2CCL11, CD40LG, IL17A, IL6
26aspirin43 49 28 2412.2CD40LG, ITGB3, APOH, CCL11, MTHFR
27cocaine43 1210.2MBP, APOH, CD40LG
28dexamethasone43 49 28 1212.1IL17A, IL6, CD40LG, CCL11, AQP4
29phosphatidylserine43 28 1211.1CD40LG, MBP, APOH, ITGB3
30herbimycin a43 5910.0CD40LG, IL6, CCL11
31ivig439.0CD40LG, APOH, MBP, IL6
32prednisolone43 28 1211.0MBP, CCL11, IL6, APOH
33n acetylcysteine438.9CCL11, IL6, CD40LG, MBP
34vegf438.8IL6, IL17A, APOH, ITGB3, CCL11, CD40LG
35lactate438.7CD40LG, MBP, APOH, IL6
36heparin43 28 24 1211.7APOH, CD40LG, MTHFR, MBP, CCL11
37indomethacin43 28 59 1211.7IL6, CCL11, IL17A, CD40LG, MBP
38fibrinogen438.6IL6, ITGA2B, CD40LG, ITGB3, MTHFR, APOH
39methotrexate49 43 1210.6MTHFR, IL17A, IL6, MBP, APOH
40thymidine43 249.5IL6, CCL11, MTHFR, IL17A, MBP
41aspartate438.4ITGB3, CD40LG, MBP, MTHFR
42creatinine438.3IL17A, IL6, MBP, CD40LG, MTHFR, APOH
43cyclosporin a43 28 5910.2MBP, IL17A, MTHFR, CCL11, CD40LG, IL6
44retinoic acid43 249.2AQP4, MTHFR, IL6, CCL11, MBP, CD40LG
45alanine438.1ITGB3, CCL11, IL6, MBP, CD40LG, MTHFR
46glutamate438.0MBP, HLA-DPB1, CD40LG, MTHFR, AQP4, AMPH
47estrogen437.8MTHFR, ITGB3, IL17A, IL6, MBP, CD40LG
48lipid437.7AMPH, MBP, ITGB3, IL6, IL17A, CCL11
49serine437.7MTHFR, ITGB3, ITGA2B, CD27, CD40LG, MBP
50cysteine437.7AQP4, MTHFR, MBP, ITGA2B, CD40LG, CD27

GO Terms for genes affiliated with Myelitis

About this section

Cellular components related to Myelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:00310929.7ITGB3, ITGA2B
2integrin complexGO:00083059.7ITGB3, ITGA2B
3extracellular spaceGO:00056158.7CD40LG, IL6, IL17A, CCL11, APOH
4integral component of plasma membraneGO:00058878.2AQP4, CD40LG, CD27, ITGA2B, ITGB3
5external side of plasma membraneGO:00098978.2AQP4, ITGA2B, IL17A, IL6, CD27, CD40LG

Biological processes related to Myelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:00093149.9CCL11, AQP4
2negative regulation of lipid storageGO:00108889.4IL6, ITGB3
3platelet aggregationGO:00705279.4ITGA2B, ITGB3
4inflammatory responseGO:00069549.1CCL11, IL17A, IL6, CD40LG
5platelet activationGO:00301688.9CD40LG, IL6, ITGA2B, ITGB3

Molecular functions related to Myelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1CD40LG, IL6, IL17A
2protein bindingGO:00055156.6AMPH, CCL11, ITGB3, ITGA2B, IL6, MBP

Products for genes affiliated with Myelitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Myelitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet