Myelitis malady

Wikipedia: Myelitis involves the infection or the inflammation of white matter or gray matter of spinal cord which...⁴⁴ more...

MalaCards: Myelitis, also known as myelitis (disorder), is related to transverse myelitis and neuromyelitis optica. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Immune response_TLR signaling pathways and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds cyclophosphamide and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and breast, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Descriptions:

myelitis 6 30 8 32 43 myelitis (disorder) 6

Diseases related to myelitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 276)

id	Related Disease	Score	Top Affiliating Genes
1	transverse myelitis	33.9	AQP4, APOH, MBP
2	neuromyelitis optica	30.0	IL6, AQP4, MBP, IFNB1
3	encephalomyelitis	28.1	CD40LG, IL17A, IL6, AQP4, MBP, CCL11
4	systemic lupus erythematosus	27.6	CD40LG, IL17A, IL6, APOH, IFNB1
5	optic neuritis	26.1	CD40LG, AQP4, APOH, MBP, IFNB1, DPYSL5
6	neuritis	26.1	CD40LG, AQP4, APOH, MBP, IFNB1, DPYSL5
7	lupus erythematosus	25.7	MTHFR, CD40LG, IL17A, IL6, AQP4, APOH
8	herpes simplex	24.9	ATM, CD40LG, IL6, AQP4, MBP, IFNB1
9	multiple sclerosis	22.8	MTHFR, ATM, CD40LG, IL17A, IL6, AQP4
10	breast cancer	22.5	MTHFR, ATM, CD40LG, IL17A, IL6, MBP
11	acute disseminated encephalomyelitis	13.3	AQP4, MBP
12	collagenous colitis	13.3	CD40LG, APOH
13	evans' syndrome	13.2	IL6, APOH
14	cutaneous lupus erythematosus	13.1	CD40LG, IL17A, APOH
15	retinal vasculitis	13.1	APOH, IFNB1
16	nodular regenerative hyperplasia	13.1	IL6, APOH
17	cryptosporidiosis	13.1	CD40LG, CCL11
18	stiff-person syndrome	13.1	AMPH, DPYSL5
19	cerebral amyloid angiopathy	13.0	IL6, AQP4, MBP
20	tropical spastic paraparesis	13.0	MBP, IFNB1
21	central pontine myelinolysis	13.0	AQP4, MBP, IFNB1
22	gliosis	13.0	IL6, AQP4, MBP
23	chronic inflammatory demyelinating polyradiculoneuropathy	13.0	CD40LG, MBP, IFNB1
24	polyradiculoneuropathy	13.0	CD40LG, MBP, IFNB1
25	hepatitis a	13.0	CD40LG, APOH, RNASEL
26	meningoencephalitis	13.0	CD40LG, IL6, MBP
27	progressive multifocal leukoencephalopathy	12.9	CD40LG, MBP, IFNB1
28	polyarteritis nodosa	12.9	CD40LG, IL6, APOH
29	subacute sclerosing panencephalitis	12.9	IL17A, IL6, MBP
30	central nervous system disease	12.9	CD40LG, IL6, APOH
31	systemic scleroderma	12.9	CD40LG, IL17A, APOH
32	pyoderma gangrenosum	12.9	CD40LG, IL6, APOH
33	spinal cord disease	12.9	ATM, AQP4, MBP
34	pyoderma	12.9	CD40LG, IL6, APOH
35	neonatal stroke	12.9	MTHFR, AQP4
36	hepatic vein thrombosis	12.9	MTHFR, APOH
37	spinal cord infarction	12.9	MTHFR, APOH
38	amaurosis fugax	12.9	MTHFR, APOH
39	transient cerebral ischemia	12.9	MTHFR, APOH
40	q fever	12.9	CD40LG, IL6, APOH
41	common wart	12.9	IL6, IFNB1
42	mixed connective tissue disease	12.9	CD40LG, IL6, APOH
43	infectious mononucleosis	12.9	CD40LG, IL6, APOH
44	waldenstrom macroglobulinemia	12.9	CD40LG, IL6, MBP
45	systemic lupus erythematosus, association with	12.9	CD40LG, IL6, APOH
46	retinal vascular occlusion	12.9	MTHFR, APOH
47	parainfluenza virus type 3	12.9	IFNB1, RNASEL
48	leptospirosis	12.9	CD40LG, IL6, APOH
49	intracranial thrombosis	12.9	MTHFR, APOH
50	macroglobulinemia	12.9	CD40LG, IL6, MBP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myelitis:

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MGI Mouse Phenotypes related to myelitis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.1	IFNB1, MBP, IL6, ATM
2	hematopoietic system phenotype	MP:0005397	6.9	RNASEL, IFNB1, CCL11, MBP, IL6, IL17A
3	mortality/aging	MP:0010768	6.8	MBP, APOH, AQP4, IL6, IL17A, CD40LG
4	nervous system phenotype	MP:0003631	6.4	MTHFR, DPYSL5, AMPH, IFNB1, MBP, AQP4

Articles related to myelitis:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection. (18805556)	Heerlein K.... Wildemann B.	2009	AQP4
2	A case of anti-AQP4 antibody-positive recurrent myelitis overlapped with autoimmune disorders including incomplete CREST syndrome revealed multiple discontinuous cord lesions (19348177)	Takahashi M.... Matsumoto S.	2009	AQP4
3	Transverse myelitis: amphiphysin autoimmunity paraneoplastic syndrome in a woman with breast cancer. (19398941)	Virani S.... Abraham J.	2009	AMPH
4	Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis. (19917985)	Yanagawa K.... Nishizawa M.	2009	IL6, MBP, AQP4
5	Neuromyelitis optica (NMO) antibody positivity in patients with transverse myelitis and no visual manifestations. (18432545)	Hamnik S.E.... Jay W.	2008	MBP, AQP4
6	Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis. (18809833)	Tanaka M.... Kira J.I.	2008	CCL11
7	Intracellular immune dysfunction in myalgic encephalo myelitis/chronic fatigue syndrome: state of the art and therapeutic implication s. (18269338)	Nijs J.... FrAcmont M.	2008	RNASEL
8	Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. (18625857)	Waters P.... Vincent A.	2008	AQP4
9	Subacute transverse myelitis with Lyme profile dissoc iation. (19675732)	Walid M.S.... Ulm A.J.	2008	CD40LG
10	Interleukin-17 in transverse myelitis and multiple sclerosis. (18417225)	Graber J.J.... Calabresi P.A.	2008	IL17A
11	Longitudinal myelitis in patient with systemic lupus erythematosus, homozygous prothrombin G20210A and heterozygous MTHFR 677T. (17670851)	Touma Z.... Arayssi T.	2007	MTHFR
12	Ascending myelitis in association with herpes simplex virus. A case report. (9436377)	Miyamoto M.... Maruyama H.	1997	MBP
13	Recurrent demyelinating transverse myelitis in a high titer HBs-antigen carrier. (8856658)	Matsui M.... Kuroda Y.	1996	MBP
14	Bilateral optic neuritis and transverse myelitis ass ociated with anticardiolipin antibodies (8183007)	Arkuch Saade M.E.... Borges Trujillo R.	1994	APOH
15	Transverse myelitis: a manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies. (2313670)	Lavalle C.... AlarcA^n-Segovia D.	1990	APOH

Genes related to myelitis according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	AQP4	aquaporin 4	11.0	Publications
2	MBP	myelin basic protein	11.0	Publications
3	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
4	AMPH	amphiphysin	11.0	Publications
5	IL17A	interleukin 17A	11.0	Publications
6	CD40LG	CD40 ligand	11.0	Publications
7	NUDT15	nudix (nucleoside diphosphate linked moiety X)-type motif 15	11.0
8	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	11.0	Publications
9	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
10	DPYSL5	dihydropyrimidinase-like 5	11.0
11	IFNB1	interferon, beta 1, fibroblast	11.0
12	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
13	ATM	ataxia telangiectasia mutated	11.0
14	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to myelitis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Immune response_TLR signaling pathways41	9.0	IL6, CCL11, IFNB1
2	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	8.7	IFNB1, CCL11, IL6
3	Cytokine-cytokine receptor interaction20	8.3	CD40LG, IL17A, IL6, CCL11, IFNB1

Compounds related to myelitis according to GeneDecks:

(show top 50)    (show all 60)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	APOH
2	heparin32 9 18 9	13.2	MBP, CCL11
3	ivig32	10.2	MBP, IFNB1
4	pge232	10.1	IL17A, CCL11
5	ly29400232	10.1	IL6, IL17A
6	sandoglobulin32	10.0	CD40LG, IL6
7	edss32	9.9	MBP, IFNB1
8	estrogen32	9.8	MBP, APOH, MTHFR
9	methacholine32 9 9	11.8	CCL11, MBP, IL17A
10	etanercept32 9 9	11.7	APOH, IL6, IL17A
11	vegf32	9.7	CD40LG, APOH, IFNB1
12	endotoxin32	9.7	APOH, CCL11, IFNB1
13	infliximab32 9 9	11.6	IL17A, IL6, APOH
14	groalpha32	9.6	CCL11, IL6, IL17A
15	dextran sulfate32	9.6	APOH, IL6, CD40LG
16	lipoteichoic acid32	9.5	IFNB1, APOH, IL6
17	ribavirin32 34 9 9	12.5	RNASEL, IFNB1, CD40LG
18	prednisolone32 9 9	11.4	IL6, APOH, MBP, CCL11
19	2,5-oligoadenylate32	9.4	RNASEL, IFNB1, IL6
20	ccl432	9.3	IL17A, CCL11, IFNB1
21	poly(i-c)32	9.3	IFNB1, CCL11, IL6
22	vitamin b1232	9.3	APOH, CD40LG, MTHFR
23	peptidoglycan32	9.2	IFNB1, CCL11, IL6
24	ifn-alpha32	9.2	RNASEL, IFNB1, IL6, IL17A
25	mitoxantrone32 9 9	11.2	IFNB1, MBP, ATM
26	p00232	9.2	IFNB1, APOH, IL17A, MTHFR
27	ccl332	9.1	IFNB1, CCL11, IL6
28	aspirin32 34 18	11.1	CCL11, APOH, CD40LG, MTHFR
29	herbimycin a32 42	10.1	CD40LG, IL6, CCL11, IFNB1
30	rituximab32 34 9 9	12.1	APOH, IL6, CD40LG
31	prostaglandin32	9.1	IFNB1, CCL11, IL6, IL17A
32	neopterin32	9.0	CD40LG, IL6, IFNB1
33	rantes32	8.8	IFNB1, CCL11, IL6, IL17A, CD40LG
34	actinomycin d32	8.8	CD40LG, IL17A, IL6, CCL11, IFNB1
35	sb 20358032 42	9.7	IL17A, IL6, CCL11, IFNB1
36	glutamate32	8.7	AMPH, IFNB1, MBP, APOH, AQP4, MTHFR
37	lactate32	8.6	ATM, CD40LG, IL6, APOH, MBP
38	indomethacin32 9 9	10.6	IFNB1, CCL11, MBP, IL6, IL17A, CD40LG
39	n acetylcysteine32	8.6	CCL11, MBP, IL6, CD40LG, ATM
40	dexamethasone32 42 34 9 9	12.5	IFNB1, CCL11, AQP4, IL6, IL17A, CD40LG
41	cyclosporin a32 42	9.5	MTHFR, CD40LG, IL17A, IL6, MBP, CCL11
42	methotrexate32 34 42 9 9	12.4	IFNB1, MBP, APOH, IL6, IL17A, MTHFR
43	thymidine32 18	9.3	IFNB1, CCL11, MBP, IL6, IL17A, MTHFR
44	genistein32 9 18 9	11.3	IFNB1, CCL11, IL6, CD40LG, ATM
45	cisplatin32 34 9 9	11.3	IFNB1, MBP, CD40LG, ATM, MTHFR
46	alanine32	8.1	IFNB1, CCL11, MBP, IL6, CD40LG, MTHFR
47	nitric oxide32 9 18 9	11.1	RNASEL, CCL11, APOH, IL6, IL17A, ATM
48	creatinine32	8.1	IFNB1, MBP, APOH, IL6, IL17A, CD40LG
49	retinoic acid32 42 18	10.0	IFNB1, CCL11, MBP, AQP4, IL6, CD40LG
50	lipid32	7.5	AMPH, IFNB1, CCL11, MBP, APOH, IL6

Cellular components related to myelitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.1	CD40LG, IL17A, IL6, APOH, CCL11, IFNB1

Biological processes related to myelitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	B cell proliferation	GO:042100	9.6	CD40LG, IFNB1
2	defense response to virus	GO:051607	9.0	IL6, IFNB1, RNASEL
3	inflammatory response	GO:006954	8.6	CD40LG, IL17A, IL6, CCL11

Molecular functions related to myelitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.8	CD40LG, IL17A, IL6, IFNB1