MCID: MYL001
MIFTS: 52

Myelitis malady

Summaries for Myelitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myelitis involves the infection or the inflammation of white matter or gray matter of spinal cord which... more...

MalaCards: Myelitis is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Rheumatoid arthritis and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds endotoxin and estrogen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are skeleton and renal/urinary system.

Aliases & Classifications for Myelitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

myelitis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:322
NCIt39 C26832
MeSH34 D009187

Related Diseases for Myelitis

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17GeneCards, 18GeneDecks
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Diseases related to Myelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 269)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.9CD40LG, APOH
2systemic lupus erythematosus30.9IFNAR1, IFNB1, APOH, HLA-DPB1, CD40LG, IL17A
3neuromyelitis optica30.7IFNB1, MBP, AQP4
4multiple sclerosis30.6CCL11, IFNAR1, IFNB1, MBP, HLA-DPB1, IL17A
5pneumonia30.6IL6, IL17A, CCL11
6hepatitis30.6CCL11, IFNB1, CD40LG
7neuritis30.5MBP
8optic neuritis30.5IFNB1, MBP, AQP4
9encephalitis30.5AMPH, MBP, DPYSL5, IL17A, AQP4
10meningitis30.4IL6
11transverse myelitis30.4AQP4, APOH, MBP
12neuropathy30.4DPYSL5, MBP
13encephalomyelitis30.4IFNB1, MBP, IL17A, AQP4
14antiphospholipid syndrome30.3CD40LG, MTHFR, APOH
15lyme disease30.3CD40LG, MBP
16measles30.2IFNB1, MBP, CD40LG
17hepatitis b30.2MBP
18rubella30.2CD40LG
19lung cancer30.2DPYSL5
20influenza30.2IFNB1, CCL11
21hepatitis c30.2CD40LG, IFNB1, IFNAR1
22myasthenia gravis30.1HLA-DPB1, MBP
23viral hepatitis30.1IFNB1
24arthritis30.1IL17A, IL6
25herpes simplex30.1IFNB1, ATM, RNASEL
26sarcoidosis30.0CCL11
27sjogren's syndrome30.0CD40LG, APOH
28hypertension30.0MTHFR
29vasculitis30.0IL17A, CD40LG, APOH
30connective tissue disease30.0IL6, CD40LG, APOH
31mixed connective tissue disease29.9APOH
32meningoencephalitis29.9MBP
33atopic dermatitis29.9CCL11
34polyneuropathy29.9CD40LG, MBP
35dermatitis29.9CCL11, IL17A
36rheumatoid arthritis29.8CCL11, IFNB1, APOH, HLA-DPB1, ITGB3, MTHFR
37breast cancer29.8CCL11, AMPH, IFNB1, MBP, ITGB3, ATM
38leukemia29.8CCL11, IFNB1, MBP, ITGB3, ITGA2B, ATM
39glomerulonephritis29.7CD40LG
40dengue hemorrhagic fever29.7CD40LG
41malaria29.7IFNAR1
42leptospirosis29.7CD40LG
43myocarditis29.7IFNB1
44guillain-barre syndrome29.7MBP, CD40LG
45cholera29.7CCL11, IFNB1, IL17A
46psoriasis29.7CCL11, IL17A, IL6
47myocardial infarction29.6MTHFR, ITGA2B, ITGB3, CCL11
48acute leukemia29.6IL17A, MTHFR, ATM
49ulcerative colitis29.6IL6, IL17A, IFNB1, CCL11
50cervicitis10.4

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to myelitis

Clinical Features for Myelitis

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Drugs & Therapeutics for Myelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myelitis

Drug clinical trials:

Search ClinicalTrials for Myelitis

Search NIH Clinical Center for Myelitis

Search CenterWatch for Myelitis

Genetic Tests for Myelitis

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Anatomical Context for Myelitis

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32MalaCards
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MalaCards organs/tissues related to Myelitis:

32
Spinal cord, Brain, Bone, Lung, Bone marrow, Breast, Kidney, B cells, T cells, Nk cells, Myeloid, Cervix, Testes, Skin, Heart, Salivary gland, Pancreas, Medulla oblongata

Animal Models for Myelitis or affiliated genes

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Sources:
36MGI
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Publications for Myelitis

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50PubMed
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Articles related to Myelitis:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Extensive myelitis associated with anti-NMDA receptor antibodies. (24373538)
2013
2
Transverse myelitis. (23186897)
2013
3
Childhood transverse myelitis and its mimics. (23608689)
2013
4
Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis. (23329376)
2013
5
Acute myelitis associated with HCV infection. (23771965)
2013
6
Immune-mediated myelitis following hepatitis B vaccination. (22498789)
2012
7
Spectrum disorder of neuromyelitis optica in a patient presenting with intractable vomiting and hiccups, transverse myelitis and acute encephalopathy. (22925418)
2012
8
Anti-AQP(4) antibody in idiopathic acute transverse myelitis with recurrent clinical course: frequency of positivity and influence in prognosis. (22925751)
2012
9
Prognostic factors of acute partial transverse myelitis. (23117920)
2012
10
Acute transverse myelitis and antiphospholipid antibodies in lupus. No evidence for anticoagulation. (20840379)
2011
11
Transverse myelitis and polymyositis associated with antiphospholipid antibody syndrome. (20493629)
2010
12
The epidemiology of transverse myelitis. (20035902)
2010
13
Clinical characteristics, prognosis, and seropositivity to the anti-aquaporin-4 antibody in Korean patients with longitudinally extensive transverse myelitis. (20049472)
2010
14
Tonic spasms in acute transverse myelitis. (19017560)
2009
15
Concurrent reactive arthritis and myelitis - a case report. (19486539)
2009
16
Mycophenolate mofetil and intravenous dexamethasone in the treatment of persistent lupus myelitis. (17343303)
2007
17
Longitudinal myelitis in patient with systemic lupus erythematosus, homozygous prothrombin G20210A and heterozygous MTHFR 677T. (17670851)
2007
18
Neurological picture. Acute longitudinal myelitis as the initial manifestation of SjAPgren's syndrome. (16705200)
2006
19
Treatment related myelitis in Hodgkin's lymphoma following stem cell transplant, chemotherapy and radiation: a case report and review of the literature. (16617406)
2006
20
A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis. (16211620)
2006
21
Idiopathic inflammatory demyelinating disorders after acute transverse myelitis. (16879297)
2006
22
Autologous blood stem cell transplantation in refractory systemic lupus erythematodes with recurrent longitudinal myelitis and cerebral infarction. (16686265)
2006
23
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
24
Recurrent transverse myelitis following neurobrucellosis: immunologic features and beneficial response to immunosuppression. (16036801)
2005
25
Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica. (15708229)
2005
26
Transverse myelitis and chronic urticaria in systemic lupus erythematosus. Case report. (15824831)
2005
27
Necrotizing myelitis in an immunocompetent child: a case report with review of literature. (14701948)
2003
28
Eosinophilic myelitis associated with atopic diathesis: a combined neuroimaging and histopathological study. (12557017)
2003
29
Human herpesvirus-7 infection of the CNS with acute myelitis in an adult bone marrow recipient. (12476296)
2002
30
Acute transverse myelitis in a 7-month-old boy. (11587418)
2001
31
Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets. (10967179)
2000
32
Neurophysiological studies in acute transverse myelitis. (11200687)
2000
33
Decrease in multiple sclerosis with acute transverse myelitis in Japan. (10494904)
1999
34
Transverse myelitis. Comparison with spinal cord presentations of multiple sclerosis. (9484367)
1998
35
Refractory hiccough heralding transverse myelitis in the primary antiphospholipid syndrome. (9493149)
1998
36
MR imaging of acute transverse myelitis (myelopathy). (9715996)
1998
37
Acute transverse myelitis caused by Coxsackie virus B4 infection: a case report. (9741555)
1998
38
Idiopathic transverse myelitis: MR characteristics. (8791931)
1996
39
Successful treatment of transverse myelitis in a child with systemic lupus erythematosus. (8677025)
1996
40
Myasthenia gravis, acute transverse myelitis, and HTLV-I. (8583226)
1995
41
Sequential development of acute meningoencephalitis and transverse myelitis caused by Epstein-Barr virus during infectious mononucleosis. (7970962)
1994
42
Myelitis following chickenpox: a case report. (8414043)
1993
43
Acute transverse myelitis associated with Mycoplasma pneumoniae infection: a case report and review of the literature. (1565540)
1992
44
Transverse myelitis following mumps in children. (1515767)
1992
45
Acute transverse myelitis in the emergency department: a case report and review of the literature. (1787286)
1991
46
Local stem cell depletion model for radiation myelitis. (3384725)
1988
47
Transverse myelitis and optic neuritis in systemic lupus erythematosus: a case report with magnetic resonance imaging findings. (3632736)
1987
48
Relapse of lupus transverse myelitis mimicked by vertebral fractures and spinal cord compression. (4063006)
1985
49
Transverse myelitis complicating Mycoplasma pneumoniae infection. (876926)
1977
50
Radiation myelitis of the dorsolumbar spinal cord. (5801130)
1969

Genetic Variations for Myelitis

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Expression for genes affiliated with Myelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelitis

Search GEO for disease gene expression data for Myelitis.

Pathways for genes affiliated with Myelitis

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Pathways related to Myelitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2HLA-DPB1
2
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9.9ITGB3, ITGA2B
3
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9.8IL17A, CD40LG, HLA-DPB1
49.7CD40LG, ITGB3, CCL11
5
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9.5IL6, ITGA2B, ITGB3
69.5ITGB3, ITGA2B, IL6
79.4AQP4, IL6, MBP
8
Immune response IFN alpha/beta signaling pathway
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9.4IFNAR1, IFNB1, RNASEL
99.3IFNAR1, IFNB1, ITGB3
109.3CCL11, IFNB1, IL6
119.3IFNAR1, IFNB1, IL6
129.2IL6, RNASEL, IFNB1
13
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9.2IL17A, IFNB1, IFNAR1, CCL11
14
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9.0IL6, CD40LG, HLA-DPB1, IFNAR1, CCL11
15
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8.7IFNAR1, IFNB1, HLA-DPB1, RNASEL, IL6
16
Hide members
8.7IFNAR1, IFNB1, HLA-DPB1, RNASEL, IL6
178.7IFNAR1, IFNB1, ITGB3, ITGA2B, IL6
18
Hide members
8.5IFNAR1, IFNB1, HLA-DPB1, CD40LG, RNASEL, IL6
19
Hide members
8.4CCL11, IFNAR1, IFNB1, ITGB3, ITGA2B, IL6

Compounds for genes affiliated with Myelitis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Myelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7APOH
2estrogen4410.7APOH
3pge24410.4CCL11
4serine4410.3IFNAR1, ITGA2B
5sandoglobulin4410.2IL6, CD40LG
6tirofiban44 1111.1ITGB3, CD40LG, ITGA2B
7abciximab44 1111.0CD40LG, ITGA2B, ITGB3
8prostaglandin4410.0IFNB1, IL17A
9groalpha4410.0CCL11, IL6, IL17A
10indomethacin44 59 28 1112.9IFNB1, MBP
112,5-oligoadenylate449.9RNASEL, IFNB1
12etanercept44 49 1111.9IL17A, IL6, APOH
13lipoteichoic acid449.7APOH, IL6, IFNB1
14p002449.6IFNB1, MTHFR, IL17A, APOH
15ribavirin44 49 1111.6IFNB1, IFNAR1, RNASEL, CD40LG
16aspirin44 49 28 2412.5CD40LG, MTHFR, ITGB3, CCL11, APOH
17prednisolone44 28 1111.5IL6, MBP, CCL11, APOH
18infliximab44 49 1111.5IL17A, APOH, IL6
19creatinine449.5IL17A, IFNB1, APOH, MBP
20poly(i-c)449.4IL6, CCL11, IFNAR1, IFNB1
21herbimycin a44 5910.4CD40LG, IL6, CCL11, IFNB1
22phosphatidylserine44 28 1111.4CD40LG, ITGB3, APOH, MBP
23mitoxantrone44 49 1111.3IFNB1, MBP, ATM
24heparin44 28 11 2412.3APOH, MTHFR, CD40LG, IFNB1, CCL11
25glutamate449.3AQP4, CD40LG, APOH, AMPH, MBP
26cyclophosphamide44 49 1111.3MBP, APOH, MTHFR, IFNB1
27methacholine44 1110.3MBP, CCL11, IL17A
28rantes449.3IL17A, CD40LG, IL6, IFNB1, CCL11
29actinomycin d449.2IL17A, CD40LG, IL6, CCL11, IFNB1
30ifn-alpha449.2IFNAR1, RNASEL, IL17A, IL6, IFNB1
31dexamethasone44 49 28 1112.2AQP4, IL6, IFNB1, CCL11, CD40LG
32n acetylcysteine449.2CD40LG, IL6, CCL11, MBP, ATM
33fibrinogen449.1IL6, CD40LG, APOH, MTHFR, ITGA2B, ITGB3
34ivig449.1CD40LG, IL6, IFNB1, MBP, APOH
35ly294002449.1IL17A, ATM, CCL11, IFNB1, IL6
36lysine449.0APOH, RNASEL, ITGA2B, ITGB3, IFNB1
37genistein44 28 59 2 11 2414.0IL6, CD40LG, IFNB1, CCL11, ATM
38cyclosporin a44 28 5911.0IL6, MBP, IL17A, CD40LG, CCL11, MTHFR
39lactate448.9APOH, ATM, CD40LG, IL6, MBP
40nitric oxide44 11 2410.8APOH, RNASEL, IL17A, CCL11, ATM, IL6
41methotrexate44 49 1110.8IL6, MBP, APOH, MTHFR, IL17A, IFNB1
42vegf448.7CCL11, IFNB1, CD40LG, IL6, APOH, IL17A
43thymidine44 249.7IL17A, MBP, IFNB1, IL6, CCL11, MTHFR
44cisplatin44 49 59 1111.5CD40LG, MTHFR, MBP, IFNB1, ATM
45cysteine448.5ITGB3, AQP4, CD40LG, MTHFR, ITGA2B, MBP
46retinoic acid44 249.4IFNB1, CCL11, MBP, MTHFR, CD40LG, IL6
47threonine448.3CCL11, MBP, ITGB3, ATM, IL17A, IFNB1
48alanine448.1ITGB3, IL6, MBP, IFNB1, CCL11, IFNAR1
49tyrosine447.9IL6, IFNAR1, MBP, ITGB3, ATM, IL17A
50lipid447.6IL6, CCL11, IFNB1, MBP, ATM, IL17A

GO Terms for genes affiliated with Myelitis

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16Gene Ontology
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Cellular components related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:0310929.9ITGA2B, ITGB3
2external side of plasma membraneGO:0098979.1AQP4, IL6, IL17A, CD40LG, ITGA2B
3extracellular spaceGO:0056158.3CCL11, IFNB1, APOH, CD40LG, IL17A, IL6

Biological processes related to Myelitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.7IL6, ITGB3
2type I interferon-mediated signaling pathwayGO:0603379.4IFNAR1, IFNB1, RNASEL
3response to virusGO:0096159.4IFNB1, IFNAR1, CCL11
4B cell proliferationGO:0421009.4CD40LG, IFNB1
5platelet activationGO:0301689.4IL6, CD40LG, ITGA2B, ITGB3
6inflammatory responseGO:0069549.3CCL11, CD40LG, IL17A, IL6
7defense response to virusGO:0516079.1IFNAR1, IFNB1, RNASEL, IL6
8cytokine-mediated signaling pathwayGO:0192218.9IL6, RNASEL, HLA-DPB1, IFNB1, IFNAR1

Molecular functions related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL6, IL17A, CD40LG, IFNB1

Products for genes affiliated with Myelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet