MCID: MYL001
MIFTS: 54

Myelitis malady

Rare diseases, Neuronal diseases categories

Summaries for Myelitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Myelitis involves the infection or the inflammation of white matter or gray matter of spinal cord which... more...

MalaCards: Myelitis is related to transverse myelitis and neuromyelitis optica. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Arf6 signaling events and Integrin alphaIIb beta3 signaling. The compounds sandoglobulin and hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Classifications for Myelitis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

myelitis 9 44 11 46 63


External Ids:

Disease Ontology9 DOID:322
MeSH36 D009187
NCIt41 C26832

Related Diseases for Myelitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Myelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1transverse myelitis31.9APOH, AQP4, MBP
2neuromyelitis optica31.0MBP, AQP4
3systemic lupus erythematosus30.8HLA-DPB1, APOH, IL17A, IL6, CD27, CD40LG
4neuritis30.8MBP
5optic neuritis30.8MBP, AQP4
6pneumonia30.7CCL11, IL17A, IL6
7encephalitis30.7AMPH, AQP4, IL17A, MBP
8encephalomyelitis30.6AQP4, IL17A, MBP
9acute disseminated encephalomyelitis30.6MBP, AQP4
10multiple sclerosis30.5HLA-DPB1, AQP4, CCL11, IL17A, IL6, MBP
11rubella30.5CD40LG
12measles30.4MBP, CD40LG
13antiphospholipid syndrome30.4APOH, MTHFR, CD40LG
14lyme disease30.4MBP, CD40LG
15tetanus30.3MBP, CD27, CD40LG
16arthritis30.3IL6, IL17A
17myasthenia gravis30.3HLA-DPB1, MBP
18vasculitis30.2CD40LG, IL17A, APOH
19syphilis30.2APOH
20toxoplasmosis30.2CD40LG
21connective tissue disease30.1APOH, IL6, CD40LG
22polyneuropathy30.1MBP, CD40LG
23scrub typhus29.9CD40LG
24guillain-barre syndrome29.9MBP, CD40LG
25ankylosing spondylitis29.9CD40LG, IL17A
26nephritis29.9APOH, IL17A, CD40LG
27breast cancer29.8AMPH, CCL11, MTHFR, ITGB3, IL17A, MBP
28lupus nephritis29.8CD40LG, APOH
29paraneoplastic syndromes29.8AMPH, IL6
30thromboembolism29.8MTHFR, APOH
31ulcerative colitis29.7IL6, IL17A, CCL11
32congenital heart disease29.7CD40LG, IL6, MTHFR
33myocardial infarction29.7ITGA2B, ITGB3, MTHFR, CCL11
34psoriasis29.6IL6, IL17A, CCL11
35rheumatoid arthritis29.6HLA-DPB1, APOH, CCL11, MTHFR, ITGB3, IL17A
36leukemia29.6CCL11, MTHFR, ITGB3, ITGA2B, IL17A, IL6
37acute transverse myelitis11.0
38lupus erythematosus10.7
39radiation myelitis10.6
40cervicitis10.4
41hepatitis10.4
42idiopathic acute transverse myelitis10.4
43meningitis10.4
44neuropathy10.4
45herpes zoster10.3
46mumps10.2
47cerebritis10.2
48paraplegia10.2
49schistosomiasis10.2
50hepatitis c10.2

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to myelitis

Symptoms for Myelitis

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Drugs & Therapeutics for Myelitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Myelitis

Genetic Tests for Myelitis

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Anatomical Context for Myelitis

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34MalaCards
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MalaCards organs/tissues related to Myelitis:

34
Spinal cord, Brain, Bone, Lung, Bone marrow, Kidney, Breast, Skin, B cells, Pancreas, Salivary gland, T cells, Nk cells, Myeloid, Heart, Testes, Medulla oblongata

Animal Models for Myelitis or affiliated genes

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Sources:
38MGI
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Publications for Myelitis

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Sources:
53PubMed
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Articles related to Myelitis:

(show top 50)    (show all 736)
idTitleAuthorsYear
1
An acute transverse myelitis attack after total body irradiation: a rare case. (23984124)
2013
2
Extensive myelitis associated with anti-NMDA receptor antibodies. (24373538)
2013
3
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
4
Pulse-triggered DTI sequence with reduced FOV and coronal acquisition at 3T for the assessment of the cervical spinal cord in patients with myelitis. (22918433)
2013
5
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
6
Human herpes virus 6-associated myelitis following allogeneic bone marrow transplantation. (22415068)
2012
7
Diagnosis and treatment of pediatric acute transverse myelitis. (23814937)
2012
8
Zoster myelitis in sickle cell anemia. (22246022)
2012
9
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
10
Stiff leg syndrome and myelitis with anti-amphiphysin antibodies: a common physiopathology? (21986240)
2011
11
Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis. (21523924)
2011
12
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
13
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
14
Magnetic resonance images of herpes zoster myelitis presenting with Brown-SAcquard syndrome. (20385921)
2010
15
Mycoplasma pneumoniae--associated transverse myelitis and rhabdomyolysis. (19135630)
2009
16
Verminous myelitis in a pit bull puppy. (19407100)
2009
17
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
18
Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient. (18810606)
2008
19
A case of anti-aquaporin-4 and anti-glutamate receptor antibodies positive myelitis presented with modest clinical signs. (18460850)
2008
20
Evidence for a causal association between oral polio vaccine and transverse myelitis: A case history and review of the Literature. (16630313)
2006
21
Transverse myelitis following general and epidural anaesthesia in a paediatric patient. (16115254)
2005
22
Acute transverse myelitis and hepatitis C virus. (15888983)
2005
23
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
24
Recurrent transverse myelitis following neurobrucellosis: immunologic features and beneficial response to immunosuppression. (16036801)
2005
25
Percutaneous embolisation and transverse myelitis: a rare association. (15366806)
2004
26
Anterior horn cell involvement in myelitis with atopic diathesis (atopic myelitis). (15101198)
2004
27
Transverse myelitis occurring in association with primary biliary cirrhosis and Sjogren's syndrome. (12741480)
2003
28
Multiphasic demyelinating disorder with acute transverse myelitis in Japanese. (12814118)
2003
29
Necrotizing myelitis in an immunocompetent child: a case report with review of literature. (14701948)
2003
30
Non-progressive viral myelitis in X-linked agammaglobulinemia. (11891104)
2002
31
Acute transverse myelitis after Japanese B encephalitis vaccination in a 4-year-old girl. (11934518)
2002
32
Transverse myelitis associated with herpes simplex virus infection. (11732777)
2001
33
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
34
Efficacy of high dose steroid therapy in children with severe acute transverse myelitis. (11459911)
2001
35
Characteristics and course of urinary tract dysfunction after acute transverse myelitis in. (11463178)
2001
36
Decrease in multiple sclerosis with acute transverse myelitis in Japan. (10494904)
1999
37
MR imaging of acute transverse myelitis. (10224833)
1999
38
Acute transverse myelitis due to spinal epidural hematoma-first manifestation of severe hemophilia. (10745339)
1999
39
Absence of thoracic radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for Stage III nonsmall-cell lung cancer. (9457819)
1998
40
A case of acute transverse myelitis affecting the entire length of the spinal cord. (9208267)
1997
41
Postural hypotension in a patient with acute myelitis. (8731714)
1996
42
Corynebacterium jeikeium meningitis and transverse myelitis in a neutropenic patient. (1425720)
1992
43
Accelerated treatment and radiation myelitis. (1902318)
1991
44
Local stem cell depletion model for radiation myelitis. (3384725)
1988
45
Hyperbaric oxygen therapy for radiation myelitis. (4082347)
1985
46
Transverse myelitis due to meningovascular syphilis. (6696656)
1984
47
Leads from the MMWR. Acute schistosomiasis with transverse myelitis in American students returning from Kenya. (6471329)
1984
48
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
49
Transient iatrogenic transverse myelitis. (900457)
1977
50
Syphilitic Meningo-Myelitis: Erysipelas: Recovery. (20759725)
1901

Variations for Myelitis

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Expression for genes affiliated with Myelitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelitis

Search GEO for disease gene expression data for Myelitis.

Pathways for genes affiliated with Myelitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 58SinoBiological, 55R&D Systems, 54QIAGEN
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Pathways related to Myelitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, ITGA2B
2
Show member pathways
9.7ITGA2B, ITGB3
39.7ITGA2B, ITGB3
49.7ITGA2B, ITGB3
59.6IL6, CCL11
6
Show member pathways
Serotonin Transporter Activity39
9.5ITGB3, AMPH
79.4CD40LG, ITGB3, CCL11
8
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.4CD40LG, IL6, IL17A
99.3HLA-DPB1, IL17A, IL6
10
Show member pathways
9.2HLA-DPB1, CD27, CD40LG
11
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.2IL6, ITGA2B, ITGB3
129.2IL6, ITGA2B, ITGB3
13
Show member pathways
9.2ITGA2B, ITGB3, AMPH
14
Show member pathways
9.0CD40LG, IL6, IL17A, HLA-DPB1
15
Show member pathways
9.0HLA-DPB1, CCL11, IL6, CD40LG
168.9MBP, IL6, AQP4
17
Show member pathways
8.9CCL11, ITGB3, ITGA2B, IL6
18
Show member pathways
8.9CCL11, ITGB3, ITGA2B, IL6
19
Show member pathways
8.4CCL11, IL17A, IL6, CD27, CD40LG

Compounds for genes affiliated with Myelitis

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Myelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1sandoglobulin4610.0CD40LG, IL6
2hydroxychloroquine46 1211.0APOH, CD40LG
3obtustatin6210.0ITGB3, ITGA2B
4a 2869826210.0ITGB3, ITGA2B
5bio 12116210.0ITGB3, ITGA2B
6leukadherin 16210.0ITGB3, ITGA2B
7tc-i 156210.0ITGB3, ITGA2B
8tirofiban46 1210.8CD40LG, ITGA2B, ITGB3
9abciximab46 1210.8CD40LG, ITGA2B, ITGB3
10vitamin b12469.8APOH, MTHFR, CD40LG
11etanercept46 52 1211.8APOH, IL17A, IL6
12infliximab46 52 1211.8IL6, IL17A, APOH
13groalpha469.8CCL11, IL17A, IL6
14dextran sulfate469.7APOH, IL6, CD40LG
15rituximab46 52 1211.7CD40LG, IL6, APOH
16p002469.7IL17A, MTHFR, APOH
17sele469.6MTHFR, ITGB3
18pravastatin46 52 30 25 1213.4MTHFR, IL6, CD40LG
19rantes469.4CD40LG, IL6, IL17A, CCL11
20methacholine46 52 1211.4CCL11, IL17A, MBP
21histamine46 30 2511.4AQP4, CCL11, IL6, CD40LG
22hyaluronic acid46 2510.3CD40LG, IL6, CCL11
23actinomycin d469.3CCL11, IL17A, IL6, CD40LG
24endotoxin469.2APOH, CCL11, IL17A, IL6, CD40LG
25pge2469.2CCL11, IL17A, IL6, CD40LG
26aspirin46 52 30 2512.2APOH, CCL11, MTHFR, ITGB3, CD40LG
27cocaine46 1210.2CD40LG, MBP, APOH
28dexamethasone46 52 30 1212.1AQP4, CCL11, IL17A, IL6, CD40LG
29phosphatidylserine46 30 1211.1CD40LG, MBP, ITGB3, APOH
30herbimycin a46 6210.0CCL11, IL6, CD40LG
31ivig469.0APOH, IL6, MBP, CD40LG
32prednisolone46 30 1211.0APOH, CCL11, IL6, MBP
33n acetylcysteine468.9CD40LG, MBP, IL6, CCL11
34vegf468.8APOH, CCL11, ITGB3, IL17A, IL6, CD40LG
35lactate468.7CD40LG, MBP, IL6, APOH
36heparin46 30 25 1211.7APOH, CCL11, MTHFR, MBP, CD40LG
37indomethacin46 30 62 1211.7CCL11, IL17A, IL6, MBP, CD40LG
38fibrinogen468.6CD40LG, IL6, ITGA2B, ITGB3, MTHFR, APOH
39methotrexate52 46 1210.6APOH, MTHFR, IL17A, IL6, MBP
40thymidine46 259.5MBP, IL6, IL17A, MTHFR, CCL11
41aspartate468.4CD40LG, MBP, ITGB3, MTHFR
42creatinine468.3APOH, MTHFR, IL17A, IL6, MBP, CD40LG
43cyclosporin a46 30 6210.2CCL11, MTHFR, IL17A, IL6, MBP, CD40LG
44retinoic acid46 259.2AQP4, CCL11, MTHFR, IL6, MBP, CD40LG
45alanine468.1CCL11, MTHFR, ITGB3, IL6, MBP, CD40LG
46glutamate468.0HLA-DPB1, APOH, AMPH, AQP4, MTHFR, MBP
47estrogen467.8APOH, MTHFR, ITGB3, IL17A, IL6, MBP
48lipid467.7APOH, AMPH, CCL11, ITGB3, IL17A, IL6
49serine467.7MTHFR, ITGB3, ITGA2B, MBP, CD27, CD40LG
50cysteine467.7AQP4, MTHFR, ITGB3, ITGA2B, MBP, CD27

GO Terms for genes affiliated with Myelitis

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Sources:
17Gene Ontology
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Cellular components related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:0310929.7ITGA2B, ITGB3
2integrin complexGO:0083059.7ITGA2B, ITGB3
3extracellular spaceGO:0056158.7APOH, CCL11, IL17A, IL6, CD40LG
4integral component of plasma membraneGO:0058878.2CD40LG, CD27, ITGA2B, ITGB3, AQP4
5external side of plasma membraneGO:0098978.2CD40LG, AQP4, ITGA2B, IL17A, IL6, CD27

Biological processes related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:0093149.9CCL11, AQP4
2negative regulation of lipid storageGO:0108889.4IL6, ITGB3
3platelet aggregationGO:0705279.4ITGA2B, ITGB3
4inflammatory responseGO:0069549.1CCL11, IL17A, IL6, CD40LG
5platelet activationGO:0301688.9CD40LG, IL6, ITGA2B, ITGB3

Molecular functions related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1CD40LG, IL6, IL17A
2protein bindingGO:0055156.6AMPH, CCL11, ITGB3, ITGA2B, IL6, MBP

Products for genes affiliated with Myelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myelitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet