MCID: MYL001
MIFTS: 52

Myelitis malady

Summaries for Myelitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myelitis involves the infection or the inflammation of white matter or gray matter of spinal cord which... more...

MalaCards: Myelitis is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Rheumatoid arthritis and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds endotoxin and estrogen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and lung, and related mouse phenotypes are skeleton and renal/urinary system.

Aliases & Classifications for Myelitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

myelitis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:322
NCIt39 C26832
MeSH34 D009187

Related Diseases for Myelitis

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17GeneCards, 18GeneDecks
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Diseases related to Myelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 269)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.9CD40LG, APOH
2systemic lupus erythematosus30.9IFNAR1, IFNB1, APOH, HLA-DPB1, CD40LG, IL17A
3neuromyelitis optica30.7IFNB1, MBP, AQP4
4multiple sclerosis30.6CCL11, IFNAR1, IFNB1, MBP, HLA-DPB1, IL17A
5pneumonia30.6IL6, IL17A, CCL11
6hepatitis30.6CCL11, IFNB1, CD40LG
7neuritis30.5MBP
8optic neuritis30.5IFNB1, MBP, AQP4
9encephalitis30.5AMPH, MBP, DPYSL5, IL17A, AQP4
10meningitis30.4IL6
11transverse myelitis30.4AQP4, APOH, MBP
12neuropathy30.4DPYSL5, MBP
13encephalomyelitis30.4IFNB1, MBP, IL17A, AQP4
14antiphospholipid syndrome30.3CD40LG, MTHFR, APOH
15lyme disease30.3CD40LG, MBP
16measles30.2IFNB1, MBP, CD40LG
17hepatitis b30.2MBP
18rubella30.2CD40LG
19lung cancer30.2DPYSL5
20influenza30.2IFNB1, CCL11
21hepatitis c30.2CD40LG, IFNB1, IFNAR1
22myasthenia gravis30.1HLA-DPB1, MBP
23viral hepatitis30.1IFNB1
24arthritis30.1IL17A, IL6
25herpes simplex30.1IFNB1, ATM, RNASEL
26sarcoidosis30.0CCL11
27sjogren's syndrome30.0CD40LG, APOH
28hypertension30.0MTHFR
29vasculitis30.0IL17A, CD40LG, APOH
30connective tissue disease30.0IL6, CD40LG, APOH
31mixed connective tissue disease29.9APOH
32meningoencephalitis29.9MBP
33atopic dermatitis29.9CCL11
34polyneuropathy29.9CD40LG, MBP
35dermatitis29.9CCL11, IL17A
36rheumatoid arthritis29.8CCL11, IFNB1, APOH, HLA-DPB1, ITGB3, MTHFR
37breast cancer29.8CCL11, AMPH, IFNB1, MBP, ITGB3, ATM
38leukemia29.8CCL11, IFNB1, MBP, ITGB3, ITGA2B, ATM
39glomerulonephritis29.7CD40LG
40dengue hemorrhagic fever29.7CD40LG
41malaria29.7IFNAR1
42leptospirosis29.7CD40LG
43myocarditis29.7IFNB1
44guillain-barre syndrome29.7MBP, CD40LG
45cholera29.7CCL11, IFNB1, IL17A
46psoriasis29.7CCL11, IL17A, IL6
47myocardial infarction29.6MTHFR, ITGA2B, ITGB3, CCL11
48acute leukemia29.6IL17A, MTHFR, ATM
49ulcerative colitis29.6IL6, IL17A, IFNB1, CCL11
50cervicitis10.4

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to myelitis

Clinical Features for Myelitis

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Drugs & Therapeutics for Myelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myelitis

Search NIH Clinical Center for Myelitis

Search CenterWatch for Myelitis

Genetic Tests for Myelitis

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Anatomical Context for Myelitis

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32MalaCards
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MalaCards organs/tissues related to Myelitis:

32
Spinal cord, Brain, Lung, Bone, Bone marrow, Breast, Kidney, Nk cells, Cervix, Salivary gland, Pancreas, B cells, T cells, Myeloid, Testes, Heart, Skin, Medulla oblongata

Animal Models for Myelitis or affiliated genes

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36MGI
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Publications for Myelitis

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50PubMed
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Articles related to Myelitis:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Pulse-triggered DTI sequence with reduced FOV and coronal acquisition at 3T for the assessment of the cervical spinal cord in patients with myelitis. (22918433)
2013
2
Transverse myelitis and acute motor sensory axonal neuropathy due to Legionella pneumophila: A case report. (24330286)
2013
3
Acute transverse myelitis (ascending myelitis) as the initial manifestation of Japanese encephalitis: a rare presentation. (23585973)
2013
4
Distinctive clinical and neuroimaging characteristics of longitudinally extensive transverse myelitis associated with aquaporin-4 autoantibodies. (23793787)
2013
5
Acute transverse myelitis after thoracic epidural anesthesia and analgesia: should anesthesia and analgesia be blamed? (23711605)
2013
6
Giant thoracic schwannoma masquerading as transverse myelitis. (23449928)
2013
7
Human herpes virus 6-associated myelitis following allogeneic bone marrow transplantation. (22415068)
2012
8
Transverse Myelitis Associated with Anti-Ro (SSA) Autoantibodies: A Record of Two Cases. (23198244)
2012
9
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
10
Atopic myelitis in a European woman residing in Japan. (20710010)
2011
11
Primary HIV infection with acute transverse myelitis. (21804292)
2011
12
Spinal epidural abscess with myelitis and meningitis caused by Streptococcus pneumoniae in a young child. (21756576)
2011
13
Toxocara canis myelitis: clinical features, magnetic resonance imaging (MRI) findings, and treatment outcome in 17 patients. (21862933)
2011
14
Images in clinical tropical medicine. Myelitis caused by infection of Angiostrongylus cantonensis. (21118917)
2010
15
Anaesthetic management of an obstetric patient with idiopathic acute transverse myelitis. (19944593)
2010
16
Transverse myelitis affecting more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients. (19022478)
2010
17
Parainfectious myelitis associated with parvovirus B19 infection. (20339862)
2010
18
Critical illness polyneuromyopathy in a child with severe demyelinating myelitis. (19264734)
2009
19
Identifying transverse myelitis in the emergency care arena. (20118863)
2009
20
Transverse myelitis as a rare, serious complication of Mycoplasma pneumoniae infection. (19748056)
2009
21
Encephalitis and myelitis associated with dengue viral infection clinical and neuroimaging features. (18467022)
2008
22
Acute partial transverse myelitis: risk factors for conversion to multiple sclerosis. (18312402)
2008
23
A case of longitudinally extensive transverse myelitis (LETM): neuromyelitis optica. (18560921)
2008
24
Eosinophilic myelitis, a souvenir from South East Asia. (17430865)
2007
25
Idiopathic acute transverse myelitis: application of the recent diagnostic criteria. (16924043)
2006
26
Urinary retention can be the sole initial manifestation of acute myelitis. (17092521)
2006
27
Demyelinating disorders: update on transverse myelitis. (16635433)
2006
28
Successful immunosuppressive treatment and long-term follow-up of anti-Ri-associated paraneoplastic myelitis. (16980662)
2006
29
Cardiac effects of acute myelitis. (16055208)
2006
30
Transverse myelitis following general and epidural anaesthesia in a paediatric patient. (16115254)
2005
31
Protein culprit found for transverse myelitis? (16265794)
2005
32
Acute transverse myelitis due to Coxsackie virus. (15851085)
2005
33
Recurrent transverse myelitis associates with anti-Ro (SSA) autoantibodies. (14718721)
2004
34
Severe myelitis following infection with Campylobacter enteritis. (14727151)
2004
35
Determinants of prognosis of acute transverse myelitis in children. (14521523)
2003
36
Cord damage elicits brain functional reorganization after a single episode of myelitis. (14581668)
2003
37
Transverse myelitis after vaccination. (12453095)
2002
38
Myelitis caused by Cladophialophora bantiana. (12076955)
2002
39
Efficacy of high dose steroid therapy in children with severe acute transverse myelitis. (11459911)
2001
40
Myelitis and ascending flaccid paralysis due to congenital toxoplasmosis. (11641828)
2001
41
Unusual complications of varicella infection: myocarditis, incessant ventricular tachycardia and transverse myelitis. (11229263)
1998
42
Transverse myelitis following mumps in an adult -- a case report with MRI correlation. (9405004)
1997
43
Usefulness of immunoadsorption therapy for systemic lupus erythematosus associated with transverse myelitis. A case report. (8964648)
1995
44
Lyme disease presenting as isolated acute urinary retention caused by transverse myelitis: an electrophysiological and urodynamical study. (8540796)
1995
45
MRI of sequela of transverse myelitis. (1408453)
1992
46
Acute syphilitic transverse myelitis: unusual presentation of meningovascular syphilis. (3679219)
1987
47
Transverse myelitis due to meningovascular syphilis. (6696656)
1984
48
Acute schistosomiasis with transverse myelitis in American students returning from Kenya. (6431248)
1984
49
Survival in traumatic transverse myelitis. (846754)
1977
50
Transverse myelitis - association with coxsackie B3 infection? (879841)
1977

Genetic Variations for Myelitis

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Expression for genes affiliated with Myelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelitis

Search GEO for disease gene expression data for Myelitis.

Pathways for genes affiliated with Myelitis

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Pathways related to Myelitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2HLA-DPB1
2
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9.9ITGB3, ITGA2B
3
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9.8IL17A, CD40LG, HLA-DPB1
49.7CD40LG, ITGB3, CCL11
5
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9.5IL6, ITGA2B, ITGB3
69.5ITGB3, ITGA2B, IL6
79.4AQP4, IL6, MBP
8
Immune response IFN alpha/beta signaling pathway
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9.4IFNAR1, IFNB1, RNASEL
99.3IFNAR1, IFNB1, ITGB3
109.3CCL11, IFNB1, IL6
119.3IFNAR1, IFNB1, IL6
129.2IL6, RNASEL, IFNB1
13
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9.2IL17A, IFNB1, IFNAR1, CCL11
14
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9.0IL6, CD40LG, HLA-DPB1, IFNAR1, CCL11
15
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8.7IFNAR1, IFNB1, HLA-DPB1, RNASEL, IL6
16
Hide members
8.7IFNAR1, IFNB1, HLA-DPB1, RNASEL, IL6
178.7IFNAR1, IFNB1, ITGB3, ITGA2B, IL6
18
Hide members
8.5IFNAR1, IFNB1, HLA-DPB1, CD40LG, RNASEL, IL6
19
Hide members
8.4CCL11, IFNAR1, IFNB1, ITGB3, ITGA2B, IL6

Compounds for genes affiliated with Myelitis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Myelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7APOH
2estrogen4410.7APOH
3pge24410.4CCL11
4serine4410.3IFNAR1, ITGA2B
5sandoglobulin4410.2CD40LG, IL6
6tirofiban44 1111.1CD40LG, ITGA2B, ITGB3
7abciximab44 1111.0CD40LG, ITGA2B, ITGB3
8prostaglandin4410.0IL17A, IFNB1
9groalpha4410.0IL6, IL17A, CCL11
10indomethacin44 59 28 1112.9MBP, IFNB1
112,5-oligoadenylate449.9RNASEL, IFNB1
12etanercept44 49 1111.9APOH, IL17A, IL6
13lipoteichoic acid449.7IFNB1, APOH, IL6
14p002449.6IL17A, MTHFR, APOH, IFNB1
15ribavirin44 49 1111.6IFNAR1, IFNB1, CD40LG, RNASEL
16aspirin44 49 28 2412.5CCL11, APOH, ITGB3, MTHFR, CD40LG
17prednisolone44 28 1111.5CCL11, MBP, APOH, IL6
18infliximab44 49 1111.5APOH, IL17A, IL6
19creatinine449.5IFNB1, MBP, APOH, IL17A
20poly(i-c)449.4IL6, IFNB1, IFNAR1, CCL11
21herbimycin a44 5910.4CCL11, IFNB1, CD40LG, IL6
22phosphatidylserine44 28 1111.4MBP, APOH, ITGB3, CD40LG
23mitoxantrone44 49 1111.3IFNB1, MBP, ATM
24heparin44 28 11 2412.3CCL11, IFNB1, APOH, MTHFR, CD40LG
25glutamate449.3AMPH, MBP, APOH, CD40LG, AQP4
26cyclophosphamide44 49 1111.3IFNB1, MBP, APOH, MTHFR
27methacholine44 1110.3CCL11, MBP, IL17A
28rantes449.3CCL11, IFNB1, CD40LG, IL17A, IL6
29actinomycin d449.2CCL11, IFNB1, CD40LG, IL17A, IL6
30ifn-alpha449.2IFNAR1, IFNB1, RNASEL, IL17A, IL6
31dexamethasone44 49 28 1112.2CCL11, IFNB1, CD40LG, IL6, AQP4
32n acetylcysteine449.2CCL11, MBP, ATM, CD40LG, IL6
33fibrinogen449.1APOH, ITGB3, ITGA2B, MTHFR, CD40LG, IL6
34ivig449.1IL6, CD40LG, APOH, MBP, IFNB1
35ly294002449.1CCL11, IFNB1, ATM, IL17A, IL6
36lysine449.0RNASEL, ITGA2B, ITGB3, APOH, IFNB1
37genistein44 28 59 2 11 2414.0CCL11, IFNB1, ATM, CD40LG, IL6
38cyclosporin a44 28 5911.0CCL11, MBP, MTHFR, CD40LG, IL17A, IL6
39lactate448.9MBP, APOH, ATM, CD40LG, IL6
40nitric oxide44 11 2410.8CCL11, APOH, ATM, RNASEL, IL17A, IL6
41methotrexate44 49 1110.8IFNB1, MBP, APOH, MTHFR, IL17A, IL6
42vegf448.7CCL11, IFNB1, APOH, ITGB3, CD40LG, IL17A
43thymidine44 249.7CCL11, IFNB1, MBP, MTHFR, IL17A, IL6
44cisplatin44 49 59 1111.5CD40LG, MTHFR, ATM, MBP, IFNB1
45cysteine448.5IFNB1, MBP, ITGB3, ITGA2B, MTHFR, CD40LG
46retinoic acid44 249.4CCL11, IFNB1, MBP, MTHFR, CD40LG, IL6
47threonine448.3CCL11, IFNB1, MBP, ITGB3, ATM, IL17A
48alanine448.1CCL11, IFNAR1, IFNB1, MBP, ITGB3, MTHFR
49tyrosine447.9CCL11, IFNAR1, IFNB1, MBP, ITGB3, ATM
50lipid447.6CCL11, AMPH, IFNB1, MBP, APOH, ITGB3

GO Terms for genes affiliated with Myelitis

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16Gene Ontology
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Cellular components related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:0310929.9ITGA2B, ITGB3
2external side of plasma membraneGO:0098979.1AQP4, IL6, IL17A, CD40LG, ITGA2B
3extracellular spaceGO:0056158.3CCL11, IFNB1, APOH, CD40LG, IL17A, IL6

Biological processes related to Myelitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.7IL6, ITGB3
2type I interferon-mediated signaling pathwayGO:0603379.4IFNAR1, IFNB1, RNASEL
3response to virusGO:0096159.4IFNB1, IFNAR1, CCL11
4B cell proliferationGO:0421009.4CD40LG, IFNB1
5platelet activationGO:0301689.4IL6, CD40LG, ITGA2B, ITGB3
6inflammatory responseGO:0069549.3CCL11, CD40LG, IL17A, IL6
7defense response to virusGO:0516079.1IFNAR1, IFNB1, RNASEL, IL6
8cytokine-mediated signaling pathwayGO:0192218.9IL6, RNASEL, HLA-DPB1, IFNB1, IFNAR1

Molecular functions related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL6, IL17A, CD40LG, IFNB1

Products for genes affiliated with Myelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet