MCID: MYL001
MIFTS: 51

Myelitis malady

Summaries for Myelitis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Myelitis involves the infection or the inflammation of white matter or gray matter of spinal cord which... more...

MalaCards: Myelitis is related to transverse myelitis and systemic lupus erythematosus. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Rheumatoid arthritis and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds endotoxin and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are skeleton and renal/urinary system.

Aliases & Classifications for Myelitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

myelitis 8 43 10 45 61


External Ids:

Disease Ontology8 DOID:322
NCIt40 C26832
MeSH35 D009187

Related Diseases for Myelitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Myelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1transverse myelitis31.7APOH, MBP, AQP4
2systemic lupus erythematosus30.9IL6, IL17A, CD40LG, HLA-DPB1, IFNAR1, APOH
3neuromyelitis optica30.8IFNB1, AQP4, MBP
4antiphospholipid syndrome30.4MTHFR, CD40LG, APOH
5hepatitis c30.3IFNB1, CD40LG, IFNAR1
6lyme disease30.3MBP, CD40LG
7measles30.3IFNB1, MBP, CD40LG
8rubella30.2CD40LG
9viral hepatitis30.2IFNB1
10arthritis30.2IL6, IL17A
11sjogren's syndrome30.1APOH, CD40LG
12vasculitis30.1APOH, CD40LG, IL17A
13hepatitis b29.9MBP
14mixed connective tissue disease29.9APOH
15meningoencephalitis29.9MBP
16atopic dermatitis29.9CCL11
17leptospirosis29.7CD40LG
18lupus nephritis29.7APOH, CD40LG
19nephritis29.7CD40LG, APOH, IL17A
20thromboembolism29.7APOH, MTHFR
21down syndrome29.7IFNAR1, MTHFR
22cholera29.7CCL11, IFNB1, IL17A
23acute leukemia29.7IL17A, MTHFR, ATM
24ulcerative colitis29.7CCL11, IL6, IFNB1, IL17A
25acute transverse myelitis11.0
26radiation myelitis10.6
27idiopathic acute transverse myelitis10.5
28herpes zoster10.3
29acute disseminated encephalomyelitis10.2
30n syndrome10.2
31mumps10.2
32hepatitis a10.2
33guillain-barr� syndrome10.2
34axonal neuropathy10.1
35primary biliary cirrhosis10.1
36aseptic meningitis10.1
37japanese encephalitis10.1
38tetanus10.1
39brown syndrome10.1
40secondary acute transverse myelitis10.1
41acute motor axonal neuropathy10.1
42hepatitis e10.1
43spastic paraparesis10.1
44foix-alajouanine syndrome10.1
45neuritis10.0MBP
46retinal artery occlusion10.0APOH
47hemorrhagic fever10.0CD40LG
48glomerulonephritis10.0CD40LG
49dengue hemorrhagic fever10.0CD40LG
50autoimmune hemolytic anemia10.0CD40LG

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to myelitis

Clinical Features for Myelitis

Drugs & Therapeutics for Myelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myelitis

Drug clinical trials:

Search ClinicalTrials for Myelitis

Search NIH Clinical Center for Myelitis

Search CenterWatch for Myelitis

Genetic Tests for Myelitis

Anatomical Context for Myelitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Myelitis:

33
Bone marrow, Whole blood, Brain, Spinal cord, Heart, Small intestine, Kidney, Lung, Pancreas, Salivary gland, Breast, Skin, Cervix, Myeloid, Nk cells, T cells, B cells, Medulla oblongata

Animal Models for Myelitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myelitis

Sources:
51PubMed
See all sources

Articles related to Myelitis:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Imaging acute spinal myelitis with (18)F-FDG PET/CT. (24158185)
2014
2
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
3
Acute transverse myelitis in a child with Lyme disease and a review of literature. (23498570)
2013
4
Efficacy of infliximab in neuro-BehAset's disease presenting with isolated longitudinally extensive transverse myelitis. (24178704)
2013
5
Analysis of prognostic factors associated with longitudinally extensive transverse myelitis. (23037550)
2013
6
Modifications of longitudinally extensive transverse myelitis and brainstem lesions in the course of neuromyelitis optica (NMO): a population-based, descriptive study. (23566260)
2013
7
Longitudinally extensive varicella-zoster virus myelitis in a patient with multiple sclerosis. (23759816)
2013
8
Acute myelitis in a patient with vogt-koyanagi-harada disease: case report and review of the literature. (23346163)
2013
9
Diagnostic value of a "wide-range" quantitative nested real-time PCR assay for varicella zoster virus myelitis. (23934732)
2013
10
Longitudinally extensive transverse myelitis associated with dengue fever. (22605876)
2012
11
Features of varicella zoster virus myelitis and dependence on immune status. (22564884)
2012
12
Stiff leg syndrome and myelitis with anti-amphiphysin antibodies: a common physiopathology? (21986240)
2011
13
Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis. (21523924)
2011
14
Risk factors and outcomes of Guillain-BarrAc syndrome with acute myelitis. (21215910)
2011
15
Treatment of acute transverse myelitis and its early complications. (22810928)
2011
16
Teaching Video NeuroImages: Painful legs, moving toes associated with partial transverse myelitis. (21041780)
2010
17
Acute transverse myelitis in psoriatic arthritis. (20012314)
2010
18
Mycoplasma pneumoniae--associated transverse myelitis and rhabdomyolysis. (19135630)
2009
19
Self-inflicted oral injury in an infant with transverse myelitis. (19886938)
2009
20
Transverse myelitis associated with Salmonella nontyphi infection. (19434021)
2009
21
Transverse myelitis and vaccines: a multi-analysis. (19880568)
2009
22
Simultaneous transverse myelitis and acute motor axonal neuropathy in an adult. (18940993)
2008
23
Tuberculous myelitis diagnosed by elevated adenosine deaminase activity in cerebrospinal fluid. (18617398)
2008
24
Thymic hyperplasia in a patient with recurrent transverse myelitis with clinical resolution after thymectomy. (18281453)
2008
25
Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. (17570566)
2007
26
Neuroimaging of tuberculous myelitis: analysis of ten cases and review of literature. (16808820)
2006
27
Occipital neuralgia as an isolated symptom of C2 myelitis. (16942479)
2006
28
Catastrophic transverse myelitis in a patient with systemic lupus erythematosus. (17029050)
2005
29
Transverse myelitis due to echovirus type 30. (16421057)
2005
30
Anterior horn cell involvement in myelitis with atopic diathesis (atopic myelitis). (15101198)
2004
31
Recurrent varicella-zoster virus myelitis in an immunocompetent patient. (15319558)
2004
32
Longitudinal myelitis in a pregnant patient with SLE. (14984826)
2004
33
Recurrent longitudinal myelitis as primary manifestation of SLE. (15557531)
2004
34
Transverse myelitis secondary to coexistent Lyme disease and babesiosis. (12828297)
2003
35
Acute transverse myelitis associated with coxiella burnetii infection. (12532936)
2002
36
Rapid onset transverse myelitis in adolescence: implications for pathogenesis and prognosis. (10325728)
1999
37
A case of acute transverse myelitis affecting the entire length of the spinal cord. (9208267)
1997
38
Micturition disturbance in acute transverse myelitis. (8856855)
1996
39
Recurrent demyelinating transverse myelitis in a high titer HBs-antigen carrier. (8856658)
1996
40
Transverse myelitis: a complication of systemic lupus erythematosus that is associated with the antiphospholipid syndrome. (8686111)
1996
41
MR imaging of transverse myelitis using Gd-DTPA. (1564531)
1992
42
Recurrent transverse myelitis, myasthenia gravis, and autoantibodies. (1416813)
1992
43
Urinary dysfunction in transverse myelitis. (2359154)
1990
44
CT myelography and MR imaging of acute transverse myelitis. (3597883)
1987
45
Transverse myelitis associated with mycoplasma pneumoniae infection. (6282515)
1982
46
Sarcoidosis as a cause of transverse myelitis: case report. (7254896)
1981
47
Intramedullary tumor metastasis simulating radiation myelitis: report of a case. (7284968)
1981
48
Transverse myelitis. (7374316)
1980
49
Transverse myelitis with systemic lupus erythematosus. (69693)
1977
50
Tabes dorsalis of sudden onset associated with possible transverse myelitis. (5430348)
1970

Genetic Variations for Myelitis

Expression for genes affiliated with Myelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myelitis

Search GEO for disease gene expression data for Myelitis.

Pathways for genes affiliated with Myelitis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Myelitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2HLA-DPB1
2
Hide members
9.9ITGB3, ITGA2B
3
Hide members
9.8IL17A, CD40LG, HLA-DPB1
49.7CD40LG, ITGB3, CCL11
5
Hide members
9.5IL6, ITGA2B, ITGB3
69.5ITGB3, ITGA2B, IL6
79.4AQP4, IL6, MBP
8
Immune response IFN alpha/beta signaling pathway
Hide members
9.4IFNAR1, IFNB1, RNASEL
99.3IFNAR1, IFNB1, ITGB3
109.3CCL11, IFNB1, IL6
119.3IFNAR1, IFNB1, IL6
129.2IL6, RNASEL, IFNB1
13
Hide members
9.2IL17A, IFNB1, IFNAR1, CCL11
14
Hide members
9.0IL6, CD40LG, HLA-DPB1, IFNAR1, CCL11
15
Hide members
8.7IFNAR1, IFNB1, HLA-DPB1, RNASEL, IL6
16
Hide members
8.7IFNAR1, IFNB1, HLA-DPB1, RNASEL, IL6
178.7IFNAR1, IFNB1, ITGB3, ITGA2B, IL6
18
Hide members
8.5IFNAR1, IFNB1, HLA-DPB1, CD40LG, RNASEL, IL6
19
Hide members
8.4CCL11, IFNAR1, IFNB1, ITGB3, ITGA2B, IL6

Compounds for genes affiliated with Myelitis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Myelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.7APOH
2estrogen4510.7APOH
3pge24510.4CCL11
4serine4510.3IFNAR1, ITGA2B
5sandoglobulin4510.2IL6, CD40LG
6tirofiban45 1111.1ITGB3, CD40LG, ITGA2B
7abciximab45 1111.0CD40LG, ITGA2B, ITGB3
8prostaglandin4510.0IFNB1, IL17A
9groalpha4510.0CCL11, IL6, IL17A
10indomethacin45 60 29 1112.9IFNB1, MBP
112,5-oligoadenylate459.9RNASEL, IFNB1
12etanercept45 50 1111.9IL17A, IL6, APOH
13lipoteichoic acid459.7APOH, IL6, IFNB1
14p002459.6IFNB1, MTHFR, IL17A, APOH
15ribavirin45 50 1111.6IFNB1, IFNAR1, RNASEL, CD40LG
16aspirin45 50 29 2412.5CD40LG, MTHFR, ITGB3, CCL11, APOH
17prednisolone45 29 1111.5IL6, MBP, CCL11, APOH
18infliximab45 50 1111.5IL17A, APOH, IL6
19creatinine459.5IL17A, IFNB1, APOH, MBP
20poly(i-c)459.4IL6, CCL11, IFNAR1, IFNB1
21herbimycin a45 6010.4CD40LG, IL6, CCL11, IFNB1
22phosphatidylserine45 29 1111.4CD40LG, ITGB3, APOH, MBP
23mitoxantrone45 50 1111.3IFNB1, MBP, ATM
24heparin45 29 11 2412.3APOH, MTHFR, CD40LG, IFNB1, CCL11
25glutamate459.3AQP4, CD40LG, APOH, AMPH, MBP
26cyclophosphamide45 50 1111.3MBP, APOH, MTHFR, IFNB1
27methacholine45 1110.3MBP, CCL11, IL17A
28rantes459.3IL17A, CD40LG, IL6, IFNB1, CCL11
29actinomycin d459.2IL17A, CD40LG, IL6, CCL11, IFNB1
30ifn-alpha459.2IFNAR1, RNASEL, IL17A, IL6, IFNB1
31dexamethasone45 50 29 1112.2AQP4, IL6, IFNB1, CCL11, CD40LG
32n acetylcysteine459.2CD40LG, IL6, CCL11, MBP, ATM
33fibrinogen459.1IL6, CD40LG, APOH, MTHFR, ITGA2B, ITGB3
34ivig459.1CD40LG, IL6, IFNB1, MBP, APOH
35ly294002459.1IL17A, ATM, CCL11, IFNB1, IL6
36lysine459.0APOH, RNASEL, ITGA2B, ITGB3, IFNB1
37genistein45 29 60 2 11 2414.0IL6, CD40LG, IFNB1, CCL11, ATM
38cyclosporin a45 29 6011.0IL6, MBP, IL17A, CD40LG, CCL11, MTHFR
39lactate458.9APOH, ATM, CD40LG, IL6, MBP
40nitric oxide45 11 2410.8APOH, RNASEL, IL17A, CCL11, ATM, IL6
41methotrexate45 50 1110.8IL6, MBP, APOH, MTHFR, IL17A, IFNB1
42vegf458.7CCL11, IFNB1, CD40LG, IL6, APOH, IL17A
43thymidine45 249.7IL17A, MBP, IFNB1, IL6, CCL11, MTHFR
44cisplatin45 50 60 1111.5CD40LG, MTHFR, MBP, IFNB1, ATM
45cysteine458.5ITGB3, AQP4, CD40LG, MTHFR, ITGA2B, MBP
46retinoic acid45 249.4IFNB1, CCL11, MBP, MTHFR, CD40LG, IL6
47threonine458.3CCL11, MBP, ITGB3, ATM, IL17A, IFNB1
48alanine458.1ITGB3, IL6, MBP, IFNB1, CCL11, IFNAR1
49tyrosine457.9IL6, IFNAR1, MBP, ITGB3, ATM, IL17A
50lipid457.6IL6, CCL11, IFNB1, MBP, ATM, IL17A

GO Terms for genes affiliated with Myelitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:0310929.9ITGA2B, ITGB3
2external side of plasma membraneGO:0098979.1AQP4, ITGA2B, CD40LG, IL17A, IL6
3extracellular spaceGO:0056158.3IL6, CCL11, IFNB1, APOH, CD40LG, IL17A

Biological processes related to Myelitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:0108889.7ITGB3, IL6
2type I interferon-mediated signaling pathwayGO:0603379.4RNASEL, IFNB1, IFNAR1
3response to virusGO:0096159.4IFNB1, CCL11, IFNAR1
4B cell proliferationGO:0421009.4IFNB1, CD40LG
5platelet activationGO:0301689.4CD40LG, ITGA2B, ITGB3, IL6
6inflammatory responseGO:0069549.3IL17A, CD40LG, CCL11, IL6
7defense response to virusGO:0516079.1IFNB1, IFNAR1, IL6, RNASEL
8cytokine-mediated signaling pathwayGO:0192218.9IFNAR1, RNASEL, HLA-DPB1, IL6, IFNB1

Molecular functions related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL6, IL17A, CD40LG, IFNB1

Products for genes affiliated with Myelitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet