MCID: MYL001
MIFTS: 55

Myelitis malady

Rare diseases, Neuronal diseases categories
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Summaries for Myelitis

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Wikipedia:65 Myelitis involves the infection or the inflammation of the white matter or gray matter of the spinal... more...

MalaCards based summary: Myelitis is related to transverse myelitis and neuromyelitis optica. An important gene associated with Myelitis is AQP4 (aquaporin 4), and among its related pathways are Arf6 signaling events and Integrin alphaIIb beta3 signaling. The compounds sandoglobulin and hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Classifications for Myelitis

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Myelitis, Aliases & Descriptions:

Name: Myelitis 8 42 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:322
MeSH34 D009187
NCIt39 C26832

Related Diseases for Myelitis

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Diseases related to Myelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1transverse myelitis32.3MBP, AQP4, APOH
2neuromyelitis optica31.5AQP4, MBP
3neuritis31.4MBP
4optic neuritis31.3MBP, AQP4
5rubella31.1CD40LG
6acute disseminated encephalomyelitis31.0MBP, AQP4
7encephalitis30.9AMPH, MBP, IL17A, AQP4
8lyme disease30.8CD40LG, MBP
9measles30.8CD40LG, MBP
10syphilis30.8APOH
11toxoplasmosis30.7CD40LG
12pneumonia30.7IL6, CCL11, IL17A
13vasculitis30.6APOH, IL17A, CD40LG
14antiphospholipid syndrome30.6APOH, CD40LG, MTHFR
15demyelinating disease30.6IL17A, MBP, AQP4
16scrub typhus30.5CD40LG
17arthritis30.5IL17A, IL6
18tetanus30.5CD27, MBP, CD40LG
19common variable immunodeficiency30.5CD27, CD40LG
20ankylosing spondylitis30.5CD40LG, IL17A
21polyneuropathy30.4MBP, CD40LG
22myasthenia gravis30.4MBP, HLA-DPB1
23guillain-barre syndrome30.4CD40LG, MBP
24systemic lupus erythematosus30.4IL17A, HLA-DPB1, IL6, APOH, CD40LG, CD27
25connective tissue disease30.2APOH, CD40LG, IL6
26nephritis30.2IL17A, APOH, CD40LG
27lupus nephritis30.1APOH, CD40LG
28paraneoplastic syndromes30.0AMPH, IL6
29thromboembolism30.0APOH, MTHFR
30multiple sclerosis29.9AQP4, CCL11, IL17A, IL6, MBP, CD27
31ulcerative colitis29.7IL17A, IL6, CCL11
32congenital heart disease29.6MTHFR, CD40LG, IL6
33myocardial infarction29.5CCL11, ITGA2B, ITGB3, MTHFR
34breast cancer29.4MBP, IL17A, ITGB3, MTHFR, AMPH, CCL11
35psoriasis29.3CCL11, IL17A, IL6
36rheumatoid arthritis28.4ITGB3, MTHFR, CCL11, APOH, HLA-DPB1, CD27
37leukemia28.3IL6, MBP, CD27, CD40LG, ITGA2B, CCL11
38acute transverse myelitis11.0
39lupus erythematosus10.7
40radiation myelitis10.6
41retinal artery occlusion10.6APOH
42hemorrhagic fever10.5CD40LG
43thrombophlebitis10.5APOH
44limbic encephalitis10.5AMPH
45cervicitis10.5
46hepatitis10.5
47idiopathic acute transverse myelitis10.5
48bronchiolitis10.4CCL11
49cryoglobulinemia10.4CD40LG, APOH
50meningitis10.4

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to myelitis

Symptoms for Myelitis

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Drugs & Therapeutics for Myelitis

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Drug clinical trials:

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Search NIH Clinical Center for Myelitis

Genetic Tests for Myelitis

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Anatomical Context for Myelitis

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MalaCards organs/tissues related to Myelitis:

32
Spinal cord, Brain, Bone, Lung, Bone marrow, Kidney, Breast, Heart, Pancreas, Salivary gland, Skin, Testes, Cervix, Myeloid, Nk cells, T cells, B cells, Medulla oblongata

Animal Models for Myelitis or affiliated genes

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Publications for Myelitis

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Articles related to Myelitis:

(show top 50)    (show all 772)
idTitleAuthorsYear
1
Predictors of recurrence following an initial episode of transverse myelitis. (25340060)
2014
2
Transverse myelitis associated with an itchy rash and hyperckemia: neuromyelitis optica associated with dermatitis herpetiformis. (24637913)
2014
3
An acute transverse myelitis attack after total body irradiation: a rare case. (23984124)
2013
4
Extensive myelitis associated with anti-NMDA receptor antibodies. (24373538)
2013
5
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
6
Pulse-triggered DTI sequence with reduced FOV and coronal acquisition at 3T for the assessment of the cervical spinal cord in patients with myelitis. (22918433)
2013
7
Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. (23917095)
2013
8
Human herpes virus 6-associated myelitis following allogeneic bone marrow transplantation. (22415068)
2012
9
Diagnosis and treatment of pediatric acute transverse myelitis. (23814937)
2012
10
Zoster myelitis in sickle cell anemia. (22246022)
2012
11
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
12
Stiff leg syndrome and myelitis with anti-amphiphysin antibodies: a common physiopathology? (21986240)
2011
13
Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis. (21523924)
2011
14
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report. (21615962)
2011
15
Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis. (21803375)
2011
16
Mycoplasma pneumoniae--associated transverse myelitis and rhabdomyolysis. (19135630)
2009
17
Verminous myelitis in a pit bull puppy. (19407100)
2009
18
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
19
Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient. (18810606)
2008
20
A case of anti-aquaporin-4 and anti-glutamate receptor antibodies positive myelitis presented with modest clinical signs. (18460850)
2008
21
Evidence for a causal association between oral polio vaccine and transverse myelitis: A case history and review of the Literature. (16630313)
2006
22
Transverse myelitis following general and epidural anaesthesia in a paediatric patient. (16115254)
2005
23
Acute transverse myelitis and hepatitis C virus. (15888983)
2005
24
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
25
Recurrent transverse myelitis following neurobrucellosis: immunologic features and beneficial response to immunosuppression. (16036801)
2005
26
Percutaneous embolisation and transverse myelitis: a rare association. (15366806)
2004
27
Anterior horn cell involvement in myelitis with atopic diathesis (atopic myelitis). (15101198)
2004
28
Transverse myelitis occurring in association with primary biliary cirrhosis and Sjogren's syndrome. (12741480)
2003
29
Multiphasic demyelinating disorder with acute transverse myelitis in Japanese. (12814118)
2003
30
Necrotizing myelitis in an immunocompetent child: a case report with review of literature. (14701948)
2003
31
Non-progressive viral myelitis in X-linked agammaglobulinemia. (11891104)
2002
32
Acute transverse myelitis after Japanese B encephalitis vaccination in a 4-year-old girl. (11934518)
2002
33
Transverse myelitis associated with herpes simplex virus infection. (11732777)
2001
34
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck. (11710599)
2001
35
Efficacy of high dose steroid therapy in children with severe acute transverse myelitis. (11459911)
2001
36
Characteristics and course of urinary tract dysfunction after acute transverse myelitis in. (11463178)
2001
37
Decrease in multiple sclerosis with acute transverse myelitis in Japan. (10494904)
1999
38
MR imaging of acute transverse myelitis. (10224833)
1999
39
Acute transverse myelitis due to spinal epidural hematoma-first manifestation of severe hemophilia. (10745339)
1999
40
Absence of thoracic radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for Stage III nonsmall-cell lung cancer. (9457819)
1998
41
A case of acute transverse myelitis affecting the entire length of the spinal cord. (9208267)
1997
42
Postural hypotension in a patient with acute myelitis. (8731714)
1996
43
Corynebacterium jeikeium meningitis and transverse myelitis in a neutropenic patient. (1425720)
1992
44
Accelerated treatment and radiation myelitis. (1902318)
1991
45
Local stem cell depletion model for radiation myelitis. (3384725)
1988
46
Hyperbaric oxygen therapy for radiation myelitis. (4082347)
1985
47
Transverse myelitis due to meningovascular syphilis. (6696656)
1984
48
Leads from the MMWR. Acute schistosomiasis with transverse myelitis in American students returning from Kenya. (6471329)
1984
49
Optic neuritis, transverse myelitis, and anti-DNA antibodies nine years after thymectomy for myasthenia gravis. (6610427)
1984
50
Syphilitic Meningo-Myelitis: Erysipelas: Recovery. (20759725)
1901

Variations for Myelitis

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Expression for genes affiliated with Myelitis

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Expression patterns in normal tissues for genes affiliated with Myelitis

Search GEO for disease gene expression data for Myelitis.

Pathways for genes affiliated with Myelitis

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Pathways related to Myelitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ITGB3, ITGA2B
2
Show member pathways
9.7ITGA2B, ITGB3
39.7ITGA2B, ITGB3
49.7ITGA2B, ITGB3
59.6IL6, CCL11
6
Show member pathways
Serotonin Transporter Activity37
9.5ITGB3, AMPH
79.4CD40LG, ITGB3, CCL11
8
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4CD40LG, IL6, IL17A
99.3HLA-DPB1, IL17A, IL6
10
Show member pathways
9.2HLA-DPB1, CD27, CD40LG
11
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.2IL6, ITGA2B, ITGB3
129.2IL6, ITGA2B, ITGB3
13
Show member pathways
9.2ITGA2B, ITGB3, AMPH
14
Show member pathways
9.0CD40LG, IL6, IL17A, HLA-DPB1
15
Show member pathways
9.0HLA-DPB1, CCL11, IL6, CD40LG
168.9MBP, IL6, AQP4
17
Show member pathways
8.9CCL11, ITGB3, ITGA2B, IL6
18
Show member pathways
8.9CCL11, ITGB3, ITGA2B, IL6
19
Show member pathways
8.4CCL11, IL17A, IL6, CD27, CD40LG

Compounds for genes affiliated with Myelitis

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Compounds related to Myelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1sandoglobulin4410.0CD40LG, IL6
2hydroxychloroquine44 1111.0APOH, CD40LG
3bio 12116110.0ITGA2B, ITGB3
4obtustatin6110.0ITGB3, ITGA2B
5tc-i 156110.0ITGA2B, ITGB3
6a 2869826110.0ITGA2B, ITGB3
7leukadherin 16110.0ITGA2B, ITGB3
8tirofiban44 1110.8ITGA2B, ITGB3, CD40LG
9abciximab44 1110.8ITGB3, ITGA2B, CD40LG
10vitamin b12449.8CD40LG, APOH, MTHFR
11etanercept44 50 1111.8APOH, IL17A, IL6
12infliximab44 50 1111.8IL6, APOH, IL17A
13groalpha449.8IL17A, CCL11, IL6
14dextran sulfate449.7CD40LG, APOH, IL6
15rituximab44 50 1111.7APOH, IL6, CD40LG
16p002449.7APOH, IL17A, MTHFR
17sele449.6MTHFR, ITGB3
18pravastatin44 50 28 24 1113.4IL6, CD40LG, MTHFR
19rantes449.4IL6, CD40LG, IL17A, CCL11
20methacholine44 50 1111.4CCL11, MBP, IL17A
21histamine44 28 2411.4AQP4, CCL11, CD40LG, IL6
22hyaluronic acid44 2410.3CCL11, IL6, CD40LG
23actinomycin d449.3IL6, IL17A, CCL11, CD40LG
24endotoxin449.2CCL11, IL17A, IL6, CD40LG, APOH
25pge2449.2CCL11, CD40LG, IL17A, IL6
26aspirin44 50 28 2412.2CD40LG, ITGB3, APOH, CCL11, MTHFR
27cocaine44 1110.2MBP, APOH, CD40LG
28dexamethasone44 50 28 1112.1IL17A, IL6, CD40LG, CCL11, AQP4
29phosphatidylserine44 28 1111.1CD40LG, MBP, APOH, ITGB3
30herbimycin a44 6110.0CD40LG, IL6, CCL11
31ivig449.0CD40LG, APOH, MBP, IL6
32prednisolone44 28 1111.0MBP, CCL11, IL6, APOH
33n acetylcysteine448.9CCL11, IL6, CD40LG, MBP
34vegf448.8IL6, IL17A, APOH, ITGB3, CCL11, CD40LG
35lactate448.7CD40LG, MBP, APOH, IL6
36heparin44 28 24 1111.7APOH, CD40LG, MTHFR, MBP, CCL11
37indomethacin44 28 61 1111.7IL6, CCL11, IL17A, CD40LG, MBP
38fibrinogen448.6IL6, ITGA2B, CD40LG, ITGB3, MTHFR, APOH
39methotrexate50 44 1110.6MTHFR, IL17A, IL6, MBP, APOH
40thymidine44 249.5IL6, CCL11, MTHFR, IL17A, MBP
41aspartate448.4ITGB3, CD40LG, MBP, MTHFR
42creatinine448.3IL17A, IL6, MBP, CD40LG, MTHFR, APOH
43cyclosporin a44 28 6110.2MBP, IL17A, MTHFR, CCL11, CD40LG, IL6
44retinoic acid44 249.2AQP4, MTHFR, IL6, CCL11, MBP, CD40LG
45alanine448.1ITGB3, CCL11, IL6, MBP, CD40LG, MTHFR
46glutamate448.0MBP, HLA-DPB1, CD40LG, MTHFR, AQP4, AMPH
47estrogen447.8MTHFR, ITGB3, IL17A, IL6, MBP, CD40LG
48lipid447.7AMPH, MBP, ITGB3, IL6, IL17A, CCL11
49serine447.7MTHFR, ITGB3, ITGA2B, CD27, CD40LG, MBP
50cysteine447.7AQP4, MTHFR, MBP, ITGA2B, CD40LG, CD27

GO Terms for genes affiliated with Myelitis

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Cellular components related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:0310929.7ITGA2B, ITGB3
2integrin complexGO:0083059.7ITGA2B, ITGB3
3extracellular spaceGO:0056158.7APOH, CCL11, IL17A, IL6, CD40LG
4integral component of plasma membraneGO:0058878.2CD40LG, CD27, ITGA2B, ITGB3, AQP4
5external side of plasma membraneGO:0098978.2CD40LG, AQP4, ITGA2B, IL17A, IL6, CD27

Biological processes related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:0093149.9CCL11, AQP4
2negative regulation of lipid storageGO:0108889.4IL6, ITGB3
3platelet aggregationGO:0705279.4ITGA2B, ITGB3
4inflammatory responseGO:0069549.1CCL11, IL17A, IL6, CD40LG
5platelet activationGO:0301688.9CD40LG, IL6, ITGA2B, ITGB3

Molecular functions related to Myelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1CD40LG, IL6, IL17A
2protein bindingGO:0055156.6AMPH, CCL11, ITGB3, ITGA2B, IL6, MBP

Products for genes affiliated with Myelitis

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Sources for Myelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet