MDS
MCID: MYL040
MIFTS: 72

Myelodysplastic Syndromes (MDS) malady

Cancer category

Summaries for Myelodysplastic Syndromes

Sources:
43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. it contains immature cells, called stem cells. the stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. if you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. many of them die in the bone marrow. this means that you do not have enough healthy cells, which can lead to infection, anemia, or easy bleeding. myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. if you have symptoms, they may include shortness of breath weakness or feeling tired skin that is paler than usual easy bruising or bleeding pinpoint spots under the skin caused by bleeding fever or frequent infections myelodysplastic syndromes are rare. people at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants. nih national cancer institute

MalaCards: Myelodysplastic Syndromes, also known as dysmyelopoietic syndromes, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Myelodysplastic Syndromes is ACSL6 (acyl-CoA synthetase long-chain family member 6), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds tyrosine and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are hematopoietic system and cellular.

NIH Rare Diseases:43 Myelodysplastic syndromes (mds) are a rare group of blood disorders characterized by abnormal development of blood cells within the bone marrow. individuals with mds have abnormally low blood cell levels (low blood counts). signs and symptoms associated with mds include dizziness, fatigue, weakness, shortness of breath, bruising and bleeding, frequent infections, and headaches. in some cases, mds may progress to bone marrow failure or an acute leukemia. the exact cause of mds is unknown. it sometimes runs in families, but no disease-causing gene has been identified. treatment depends on the affected individual's age, general health, and type of mds and may include red cell and/or platelet transfusions and antibiotics. last updated: 3/23/2012

Wikipedia:64 The myelodysplastic syndromes (MDS) are hematological (blood-related) medical conditions with... more...

Description from OMIM:47 614286

Aliases & Classifications for Myelodysplastic Syndromes

Sources:
43NIH Rare Diseases, 22GTR, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 47OMIM, 61UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

myelodysplastic syndromes 43 22 45 34 31
dysmyelopoietic syndromes 61
myelodysplastic syndrome 47
mds 43


External Ids:

ICD1025 D46, D46.6, D46.9

Related Diseases for Myelodysplastic Syndromes

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Myelodysplastic Syndromes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.7IL3, CDKN2B, EPO, CSF3, MLF1, WT1
2acute myeloid leukemia31.5FLT3, MLF1, NUP214
3refractory anemia31.1IL3, CSF3, CDKN2B, EPO, FTMT, FLT3
4aplastic anemia31.1CSF3, GATA2, IL3, FLT3, EPO
5myeloproliferative disorder30.8CSF3, FLT3, EPO, IL3
6pancytopenia30.6IL3, EPO, CSF3
7pulmonary alveolar proteinosis30.6IL3
8thrombocytopenia30.6CSF3, EPO, IL3
9thalassemia30.6EPO
10wilms tumor30.5FLT3, WT1
11thrombocytosis30.5EPO, ASXL1, IL3, FLT3, CSF3
12chronic myeloid leukemia30.4NRAS, EPO, FLT3, GATA2, WT1, CSF3
13acute promyelocytic leukemia30.4CSF3, GATA2, FLT3, IL3, NRAS
14polycythemia vera30.1IL3, FLT3, ASXL1, EPO
15astrocytoma30.1CDKN2B
16precursor t-cell acute lymphoblastic leukemia29.9WT1, GATA2, IL3, CDKN2B, NUP214, FLT3
17acute lymphocytic leukemia29.9CDKN2B, FLT3, WT1, CSF3, GATA2, IL3
18acute myeloid leukemia, adult29.8WT1, FLT3, CDKN2B
19bone marrow cancer29.8FLT3, NRAS
20cyclic hematopoiesis29.8IL3, CSF3
21severe congenital neutropenia autosomal recessive 329.8IL3, CSF3
22leukemoid reaction29.8IL3, CSF3
23gastrointestinal stromal tumor29.8FLT3
24severe congenital neutropenia29.8CSF3, IL3
25diamond-blackfan anemia29.7EPO, IL3
26n syndrome11.1
27chronic myelomonocytic leukemia10.7
28char syndrome10.7
29t-cell leukemia10.6
30micro syndrome10.6
31adult syndrome10.6
32acute t cell leukemia10.6
33hematopoietic stem cell transplantation10.5
34relapsing polychondritis10.5
35juvenile myelomonocytic leukemia10.5
36hemoglobinuria10.5
37paroxysmal nocturnal hemoglobinuria10.5
38leukemia, acute myeloid, therapy-related10.5
39acute myelomonocytic leukemia10.4
40myelodysplastic syndrome, somatic10.4
41pyoderma gangrenosum10.4
42alpha thalassemia10.3
43graft versus host disease10.3
44hemochromatosis10.3
453-m syndrome10.3
46short syndrome10.3
47german syndrome10.3
48mast syndrome10.3
49down syndrome10.3
50good syndrome10.2

Graphical network of the top 20 diseases related to Myelodysplastic Syndromes:



Diseases related to myelodysplastic syndromes

Clinical Features for Myelodysplastic Syndromes

Sources:
47OMIM
See all sources

Clinical features from OMIM:

614286

Drugs & Therapeutics for Myelodysplastic Syndromes

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myelodysplastic Syndromes

Drug clinical trials:

Search ClinicalTrials for Myelodysplastic Syndromes

Search NIH Clinical Center for Myelodysplastic Syndromes

Search CenterWatch for Myelodysplastic Syndromes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myelodysplastic Syndromes cell therapies at LifeMap Discovery.

Genetic Tests for Myelodysplastic Syndromes

Sources:
22GTR
See all sources

Genetic tests related to Myelodysplastic Syndromes:

id Genetic test Affiliating Genes
1 Myelodysplastic Syndrome22

Anatomical Context for Myelodysplastic Syndromes

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Myelodysplastic Syndromes:

33
Bone marrow, Whole blood, Brain, Spinal cord, Lung, Skin, Placenta, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Myelodysplastic Syndromes:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
2 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Myelodysplastic Syndromes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Myelodysplastic Syndromes:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.2CDKN2B, ASXL1, TEC, IL3, EPO, NRAS
2MP:000538412.0GATA2, WT1, PURA, RPL22, ASXL1, FLT3
3MP:000538711.7RPL22, PURA, CSF3, WT1, FLT3, PRDM16
4MP:001076811.7NRAS, NUP214, CDKN2B, EPO, IL3, POGLUT1
5MP:000536710.7GATA2, RPL22

Publications for Myelodysplastic Syndromes

Sources:
51PubMed
See all sources

Articles related to Myelodysplastic Syndromes:

(show top 50)    (show all 1014)
idTitleAuthorsYear
1
The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes. (24080589)
2013
2
Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. (23980065)
2013
3
Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes. (22983574)
2013
4
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. (24220272)
2013
5
Higher-risk myelodysplastic syndromes with del(5q): is sequential azacitidine-lenalidomide combination the way to go? (23782079)
2013
6
Single nucleotide polymorphism array karyotyping: A diagnostic and prognostic tool in myelodysplastic syndromes with unsuccessful conventional cytogenetic testing. (24123380)
2013
7
Absent or extremely low neutrophil alkaline phosphatase activity levels in patients with myelodysplastic syndromes. (23411705)
2013
8
High levels of vascular endothelial growth factor protein expression are associated with an increased risk of transfusion dependence in myelodysplastic syndromes. (23429375)
2013
9
Role of flow cytometry in myelodysplastic syndromes: diagnosis, classification, prognosis and response assessment. (23808833)
2013
10
Unveiling the paradoxical nature of myelodysplastic syndromes (MDS): why hypercellular marrow strongly favors accelerated apoptosis. (24032679)
2013
11
How we treat lower-risk myelodysplastic syndromes. (23575446)
2013
12
Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes. (23869491)
2013
13
Response to pretransplant hypomethylating agents influences the outcome of allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndromes. (23113470)
2013
14
Platelet associated IgG may be related with thrombocytopenia in patients with myelodysplastic syndromes. (22129476)
2012
15
Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites. (22391389)
2012
16
Immunophenotypic analysis of erythroid dysplasia and its diagnostic application in myelodysplastic syndromes. (22032631)
2012
17
IPSS-independent prognostic value of plasma CXCL10, IL-7 and IL-6 levels in myelodysplastic syndromes. (21912394)
2012
18
Commentary on "Myelodysplastic syndromes: challenges to improving patient and caregiver satisfaction". (22735751)
2012
19
Update on cytogenetic and molecular changes in myelodysplastic syndromes. (21877899)
2012
20
Application of French prognostic score to patients with International Prognostic Scoring System intermediate-2 or high risk myelodysplastic syndromes treated with 5-azacitidine is able to predict overall survival and rate of response. (22112007)
2012
21
Why are myelodysplastic syndromes unrecognized and underdiagnosed? A primary care perspective. (22735746)
2012
22
Overexpression of MCM2 in myelodysplastic syndromes: association with bone marrow cell apoptosis and peripheral cytopenia. (22115939)
2012
23
DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia. (21981547)
2012
24
Microarray-based comparative genomic hybridization of cancer targets reveals novel, recurrent genetic aberrations in the myelodysplastic syndromes. (22200086)
2011
25
High bone marrow angiopoietin-1 expression is an independent poor prognostic factor for survival in patients with myelodysplastic syndromes. (21878936)
2011
26
Allogeneic stem cell transplantation for myelodysplastic syndromes: critical for cure? (22035747)
2011
27
Erythroid response and decrease of WT1 expression after proteasome inhibition by bortezomib in myelodysplastic syndromes. (20971509)
2011
28
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis. (20494930)
2010
29
Increase of telomerase activity and hTERT expression in myelodysplastic syndromes. (19270495)
2009
30
An assessment of erythroid response to epoetin alpha as a single agent versus in combination with granulocyte- or granulocyte-macrophage-colony-stimulating factor in myelodysplastic syndromes using a meta-analysis approach. (19152429)
2009
31
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia. (19114693)
2009
32
Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. (19638460)
2009
33
Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS). (19020538)
2009
34
Miliary tuberculosis with no pulmonary involvement in myelodysplastic syndromes: a curable, yet rarely diagnosed, disease: case report and review of the literature. (18339200)
2008
35
Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes. (18028430)
2008
36
Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts. (17654685)
2007
37
Strategies for achieving transfusion independence in myelodysplastic syndromes. (16935559)
2007
38
Efficacy of lenalidomide in myelodysplastic syndromes. (15703420)
2005
39
A retrospective analysis of myelodysplastic syndromes with thrombocytosis: reclassification of the cases by WHO proposals. (15725469)
2005
40
Hypochromic red blood cells in low-risk myelodysplastic syndromes: effects of treatment with hemopoietic growth factors. (15590394)
2004
41
WT1 gene expression: useful marker for minimal residual disease in childhood myelodysplastic syndromes and juvenile myelo-monocytic leukemia? (15182334)
2004
42
5-azacitidine: An alternative treatment of myelodysplastic syndromes in patient with refractory response to hematopoietic growth factor, a case report and review of literatures. (15011897)
2004
43
Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes. (12802501)
2003
44
Glutathione S-transferase theta 1 gene (GSTT1) defect in Japanese patients with myelodysplastic syndromes. (9401288)
1997
45
Analysis of the erythropoietin receptor gene in patients with myeloproliferative and myelodysplastic syndromes. (8709617)
1996
46
Activity of Fgr protein-tyrosine kinase is reduced in neutrophils of patients with myelodysplastic syndromes and chronic myelogenous leukemia. (8637216)
1996
47
Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. (8695816)
1996
48
Stem cell factor improvement of proliferation and maintenance of hemopoietic progenitors in myelodysplastic syndromes. (7508532)
1994
49
Prediction of response to treatment with human recombinant erythropoietin in myelodysplastic syndromes. (8371582)
1993
50
Acute febrile neutrophilic dermatosis (Sweet's syndrome) in association with myelodysplastic syndromes: a report of three cases and a review of the literature. (2679862)
1989

Genetic Variations for Myelodysplastic Syndromes

Expression for genes affiliated with Myelodysplastic Syndromes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelodysplastic Syndromes

Search GEO for disease gene expression data for Myelodysplastic Syndromes.

Pathways for genes affiliated with Myelodysplastic Syndromes

Sources:
52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database
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Compounds for genes affiliated with Myelodysplastic Syndromes

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.8CDKN2B, WT1, CSF3, NRAS, IL3, EPO
2methylcellulose4511.6CSF3, GATA2, FLT3, EPO, IL3
3cytarabine45 50 1113.5CSF3, FLT3, CDKN2B, EPO, IL3
4imatinib45 50 1113.5WT1, EPO, IL3, CSF3, FLT3
5cyclosporin a45 29 6013.5TEC, CSF3, WT1, EPO, IL3
6thymidine45 2412.5FLT3, CSF3, IL3, EPO, WT1
7pixy3214511.4IL3, EPO, FLT3, CSF3
8retinoic acid45 2412.4IL3, CDKN2B, CSF3, WT1, GATA2, FLT3
9hydroxyurea45 50 1113.4GATA2, CSF3, IL3, EPO
10gp 1304511.4IL3, CSF3, FLT3, EPO
115-aza-2deoxycytidine4511.4IL3, EPO, FLT3, CDKN2B
12daniplestim4511.3IL3, FLT3, CSF3
13pegfilgrastim45 1112.3CSF3, IL3, EPO
14il 114511.3EPO, CSF3, IL3
15lenalidomide45 1112.3CSF3, IL3, EPO
16amifostine45 1112.3EPO, CSF3, IL3
17idarubicin45 50 1113.3CSF3, IL3, FLT3
18etoposide45 50 60 1114.3FLT3, CSF3, WT1, IL3
19gemtuzumab ozogamicin45 1112.3CSF3, FLT3, WT1
20filgrastim45 1112.3IL3, CSF3, EPO
21gm-csf45 2912.3EPO, CSF3, IL3
22mitoxantrone45 50 1113.2FLT3, IL3, CSF3
23mycophenolate mofetil45 50 1113.2CSF3, EPO, IL3
24ribavirin45 50 1113.2IL3, EPO, CSF3
25doxycycline45 1112.2EPO, IL3, CDKN2B
26melphalan45 1112.2IL3, EPO, CSF3
27daunorubicin45 50 1113.2CSF3, IL3, FLT3
28metenolone acetate4511.1CSF3, EPO
29lenograstim4511.1CSF3, IL3
30mps-l4511.1CSF3, EPO
31antithymoglobulin4511.1EPO, CSF3
32carboplatin45 50 1113.1CSF3, EPO, IL3
33cytoxan4511.1CSF3, IL3
34carboxymethylcellulose4511.1EPO, CSF3
35molgramostim4511.1CSF3, IL3
36mesna4511.1IL3, CSF3
37thiotepa45 50 1113.0CSF3, IL3
38mafosfamide4511.0CSF3, IL3
39ara-ctp4511.0CSF3, IL3
40zidovudine45 1112.0IL3, EPO, CSF3
414-hydroperoxycyclophosphamide4511.0IL3, CSF3
42azathioprine45 50 2 1114.0EPO, CDKN2B, GATA2
43homoharringtonine45 1112.0IL3, CSF3
44aclarubicin4510.9IL3, CSF3
45doxorubicin45 50 1112.9CSF3, WT1, FLT3, IL3
46vincristine45 50 1112.9WT1, CSF3, IL3
47butyrate4510.8GATA2
48oligonucleotide4510.8NRAS, FLT3, WT1, PURA, GATA2
49ag-12964510.8FLT3, IL3
50benzidine4510.7GATA2, EPO

GO Terms for genes affiliated with Myelodysplastic Syndromes

Sources:
16Gene Ontology
See all sources

Cellular components related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:00566210.7PURA, PURB

Biological processes related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.4FLT3, PURA, IL3, EPO, FTMT, NRAS
2cellular response to cytokine stimulusGO:07134510.7FLT3, CSF3
3myeloid progenitor cell differentiationGO:00231810.6MLF1, FLT3
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4IL3, EPO

Molecular functions related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C2H2 zinc finger domain bindingGO:07074210.7GATA2, WT1
2SMAD bindingGO:04633210.5PRDM16, PURA, PURB

Products for genes affiliated with Myelodysplastic Syndromes

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Sources for Myelodysplastic Syndromes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet