MDS
MCID: MYL040
MIFTS: 64

Myelodysplastic Syndromes (MDS) malady

Cancer diseases category

Summaries for Myelodysplastic Syndromes

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42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. it contains immature cells, called stem cells. the stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. if you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. many of them die in the bone marrow. this means that you do not have enough healthy cells, which can lead to infection, anemia, or easy bleeding. myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. if you have symptoms, they may include shortness of breath weakness or feeling tired skin that is paler than usual easy bruising or bleeding pinpoint spots under the skin caused by bleeding fever or frequent infections myelodysplastic syndromes are rare. people at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants. nih national cancer institute

MalaCards: Myelodysplastic Syndromes, also known as dysmyelopoietic syndromes, is related to leukemia and acute leukemia. An important gene associated with Myelodysplastic Syndromes is ACSL6 (acyl-CoA synthetase long-chain family member 6), and among its related pathways are Transcriptional misregulation in cancer and Interferon Signaling. The compounds tyrosine and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related mouse phenotypes are hematopoietic system and cellular.

NIH Rare Diseases:42 Myelodysplastic syndromes (mds) are a rare group of blood disorders characterized by abnormal development of blood cells within the bone marrow. individuals with mds have abnormally low blood cell levels (low blood counts). signs and symptoms associated with mds include dizziness, fatigue, weakness, shortness of breath, bruising and bleeding, frequent infections, and headaches. in some cases, mds may progress to bone marrow failure or an acute leukemia. the exact cause of mds is unknown. it sometimes runs in families, but no disease-causing gene has been identified. treatment depends on the affected individual's age, general health, and type of mds and may include red cell and/or platelet transfusions and antibiotics. last updated: 3/23/2012

Wikipedia:63 The myelodysplastic syndromes (MDS) are hematological (blood-related) medical conditions with... more...

Description from OMIM:46 614286

Aliases & Classifications for Myelodysplastic Syndromes

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42NIH Rare Diseases, 22GTR, 46OMIM, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

myelodysplastic syndromes 42 22 44 33 30
dysmyelopoietic syndromes 60
myelodysplastic syndrome 46
mds 42


External Ids:

ICD1025 D46, D46.6, D46.9

Related Diseases for Myelodysplastic Syndromes

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17GeneCards, 18GeneDecks
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Diseases related to Myelodysplastic Syndromes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 338)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.8EPO, CDKN2B, NUP214, NRAS, PRDM16, FLT3
2acute leukemia31.7FLT3, GATA2, WT1, EPO, MLF1, CDKN2B
3myeloid leukemia31.6CDKN2B, IL3, WT1, MLF1, FLT3, GATA2
4acute myeloid leukemia31.5NUP214, MLF1, FLT3
5aplastic anemia31.1IL3, EPO, FLT3, GATA2
6myelofibrosis30.6IL3, EPO
7pancytopenia30.6EPO, IL3
8thrombocytosis30.5ASXL1, IL3, EPO, FLT3
9chronic myeloid leukemia30.4NRAS, CDKN2B, EPO, FLT3, IL3, GATA2
10acute lymphocytic leukemia30.2IL3, GATA2, WT1, FLT3, CDKN2B
11refractory anemia30.1CDKN2B, FLT3, FTMT, WT1, EPO, IL3
12polycythemia vera30.1ASXL1, IL3, EPO, FLT3
13ovarian cancer30.1NRAS, IL3
14astrocytoma30.1CDKN2B
15deficiency anemia29.8FLT3, IL3, EPO
16polycythemia29.8IL3, EPO
17gastrointestinal stromal tumor29.8FLT3
18diamond-blackfan anemia29.7EPO, IL3
19adult syndrome10.6
20muscular dystrophy10.5
21relapsing polychondritis10.5
22juvenile myelomonocytic leukemia10.5
23hemoglobinuria10.4
24sideroblastic anemia10.4
25pyoderma10.4
26pulmonary alveolar proteinosis10.4
27pyoderma gangrenosum10.4
28childhood leukemia10.4
29lymphoblastic leukemia10.4
30myeloma10.4
31neutropenia10.4
32thalassemia10.4
33thrombocytopenia10.4
34breast cancer10.4
35pure red-cell aplasia10.3
36alpha thalassemia10.3
37multiple myeloma10.3
38graft versus host disease10.3
39hemochromatosis10.3
40eosinophilia10.3
41sarcoma10.3
42hepatitis10.3
43myelodysplastic syndrome, somatic10.3
44refractory anemia with excess blasts-110.3
45hemolytic anemia10.2
46histiocytosis10.2
47intestinal disease10.2
48pneumonia10.2
49t-cell leukemia10.2
50vasculitis10.2

Graphical network of the top 20 diseases related to Myelodysplastic Syndromes:



Diseases related to myelodysplastic syndromes

Clinical Features for Myelodysplastic Syndromes

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46OMIM
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Clinical features from OMIM:

614286

Drugs & Therapeutics for Myelodysplastic Syndromes

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Myelodysplastic Syndromes

Search CenterWatch for Myelodysplastic Syndromes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myelodysplastic Syndromes cell therapies at LifeMap Discovery.

Genetic Tests for Myelodysplastic Syndromes

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22GTR
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Genetic tests related to Myelodysplastic Syndromes:

id Genetic test Affiliating Genes
1 Myelodysplastic Syndrome22

Anatomical Context for Myelodysplastic Syndromes

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Myelodysplastic Syndromes:

32
Bone, Bone marrow, Skin, Testes, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Myelodysplastic Syndromes:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
2 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Myelodysplastic Syndromes or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myelodysplastic Syndromes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.0RPL22, ASXL1, TEC, IL3, EPO, CDKN2B
2MP:000538411.9FLT3, GATA2, WT1, PURA, RPL22, NRAS
3MP:000538711.7RPL22, ASXL1, TEC, IL3, CDKN2B, NRAS
4MP:001076811.7GATA2, FLT3, PRDM16, NRAS, POGLUT1, NUP214

Publications for Myelodysplastic Syndromes

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Genetic Variations for Myelodysplastic Syndromes

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Myelodysplastic Syndromes:

62
id Symbol AA change Variation ID SNP ID
1GATA2p.Thr354MetVAR_066406
2SETBP1p.Asp868AsnVAR_063807
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser869AsnVAR_069852
5SETBP1p.Thr873ArgVAR_069857

Expression for genes affiliated with Myelodysplastic Syndromes

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelodysplastic Syndromes

Search GEO for disease gene expression data for Myelodysplastic Syndromes.

Pathways for genes affiliated with Myelodysplastic Syndromes

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Myelodysplastic Syndromes

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44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.4FLT3, TEC, NRAS, WT1, CDKN2B, EPO
2methylcellulose4411.3IL3, GATA2, FLT3, EPO
3cytarabine44 49 1113.3CDKN2B, IL3, EPO, FLT3
4imatinib44 49 1113.3IL3, WT1, FLT3, EPO
55-aza-2deoxycytidine4411.3FLT3, CDKN2B, EPO, IL3
6butyrate4411.2WT1, GATA2, IL3, EPO
7pixy3214411.2FLT3, EPO, IL3
8oligonucleotide4411.2FLT3, GATA2, WT1, PURA, NRAS
9doxycycline44 1112.1CDKN2B, EPO, IL3
10hydroxyurea44 49 1113.1IL3, EPO, GATA2
11gp 1304411.1IL3, EPO, FLT3
12azathioprine44 49 2 1114.1CDKN2B, GATA2, EPO
13daniplestim4411.0IL3, FLT3
14pegfilgrastim44 1112.0EPO, IL3
15il 114411.0IL3, EPO
16lenalidomide44 1112.0EPO, IL3
17ag-12964410.9IL3, FLT3
18amifostine44 1111.9EPO, IL3
19idarubicin44 49 1112.8IL3, FLT3
20benzidine4410.7EPO, GATA2
21gemtuzumab ozogamicin44 1111.6FLT3, WT1
22filgrastim44 1111.4EPO, IL3

GO Terms for genes affiliated with Myelodysplastic Syndromes

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16Gene Ontology
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Cellular components related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:00566210.7PURA, PURB

Biological processes related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.1NRAS, PURA, IL3, EPO, FTMT, FLT3
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.7IL3, EPO
3myeloid progenitor cell differentiationGO:00231810.4MLF1, FLT3

Molecular functions related to Myelodysplastic Syndromes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C2H2 zinc finger domain bindingGO:07074210.7GATA2, WT1
2SMAD bindingGO:04633210.5PRDM16, PURA, PURB

Products for genes affiliated with Myelodysplastic Syndromes

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Sources for Myelodysplastic Syndromes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet