MCID: MYL005
MIFTS: 75

Myelofibrosis malady

Bone diseases, Immune diseases categories

Summaries for Myelofibrosis

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue. scarring of the bone marrow causes anemia, which can lead to fatigue and weakness, as well as pooling of the blood in abnormal sites like the liver and spleen, causing these organs to swell. although myelofibrosis can occur at any age, it typically develops after the age of 50. in most cases, myelofibrosis gets progressively worse. treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.    last updated: 8/17/2011

MalaCards: Myelofibrosis, also known as primary myelofibrosis, is related to leukemia and polycythemia. An important gene associated with Myelofibrosis is JAK2 (Janus kinase 2), and among its related pathways are Rho Family GTPases and Akt Signaling. The drug busulfan and the compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue, bone and bone marrow, and related mouse phenotypes are hematopoietic system and cellular.

Disease Ontology:8 A myeloma that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.

Genetics Home Reference:21 Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. Because of the fibrosis, the bone marrow is unable to make enough normal blood cells. The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis.

Wikipedia:63 Myelofibrosis, also known as myeloid metaplasia, chronic idiopathic myelofibrosis, osteomyelofibrosis... more...

Description from OMIM:46 254450

Aliases & Classifications for Myelofibrosis

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 21Genetics Home Reference, 34MeSH, 56SNOMED-CT, 46OMIM, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

myelofibrosis 8 42 22 10 44 30 60
primary myelofibrosis 8 42 21 44 60
agnogenic myeloid metaplasia 8 42 21 44
myeloid metaplasia 42 21 44 60
idiopathic myelofibrosis 42 21 44
chronic idiopathic myelofibrosis 8 21
megakaryocytic myelosclerosis 8 60
myelofibrosis with myeloid metaplasia 21
idiopathic bone marrow fibrosis 8
bone marrow fibrosis 8
myelosclerosis, nos 8
aleukemic myelosis 8
myelosclerosis 8


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Disease Ontology8 DOID:4971
MeSH34 D055728
OMIM46 254450
ICD9CM27 238.76
NCIt39 C2862

Related Diseases for Myelofibrosis

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17GeneCards, 18GeneDecks
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Diseases in the Myelofibrosis family:

Familial Myelofibrosis

Diseases related to Myelofibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.1IFNA2, BMP6, JAK2, GATA1, STAT5A, THPO
2polycythemia31.1CD177, EPO, IL3, THPO, MPL, STAT5A
3polycythemia vera31.1IFNA2, JAK2, STAT5A, FLT3, MPL, CD177
4acute leukemia30.9THPO, KIT, JAK2, GATA1, STAT5A, FLT3
5primary polycythemia30.8JAK2, STAT5A, EPO
6myeloid leukemia30.6FLT3, MPL, LIF, IL3, IL11, KIT
7osteosclerosis30.6TNFRSF11B, THPO
8thrombocytosis30.4THPO, IL11, IFNA2, JAK2, FLT3, MPL
9vascular disease30.4FGF2, PF4, JAK2
10leukemoid reaction30.4IL3, GATA1
11thrombocytopenia30.3IFNA2, GATA1, MPL, EPO, PF4, IL3
12sarcoma30.3JAK2, KIT, HMGA2, THPO
13megakaryocytic leukemia30.3GATA1, PF4, IL3, IL11, THPO
14pancytopenia30.2THPO, IL3, EPO, MPL
15hepatitis30.2IFNA2, AHSG
16myeloma30.2IFNA2, TNFRSF11B, JAK2, STAT5A, LIF, EPO
17multiple myeloma30.2TNFRSF11B
18obesity30.1JAK2, STAT5A, LIF, AHSG
19uremia30.1TNFRSF11B, EPO, AHSG, PF4
20chronic myeloid leukemia30.1GATA1, STAT5A, FLT3, MPL, CD177, EPO
21chronic myeloproliferative disease30.1JAK2, FLT3, MPL, THPO
22arthritis30.1FGF2, LIF, TNFRSF11B
23peritonitis30.1LIF
24hairy cell leukemia30.1IL3, FLT3, IFNA2
25monocytic leukemia30.1GATA1, LIF
26myeloid sarcoma30.1FLT3, KIT
27hyperparathyroidism30.1TNFRSF11B, EPO
28beta thalassemia30.0EPO, GATA1, TNFRSF11B
29acute lymphocytic leukemia29.9JAK2, GATA1, FLT3, MPL, IL3, KIT
30rheumatoid arthritis29.9TNFRSF11B, BMP6, JAK2, LIF, PF4, IL11
31systemic mastocytosis29.9IFNA2, JAK2, STAT5A, KIT
32hypersplenism29.9THPO
33hepatitis b29.9IFNA2
34hemorrhagic thrombocythemia29.9CD177
35porphyria29.9GATA1
36deficiency anemia29.7THPO, IFNA2, JAK2, GATA1, FLT3, MPL
37breast cancer29.7TNFRSF11B, BMP6, JAK2, STAT5A, FLT3, LIF
38neutropenia29.7IL3, IL11, THPO, EPO, CD177, LIF
39aplastic anemia29.7GATA1, FLT3, MPL, EPO, IL3, IL11
40adenocarcinoma29.7HMGA2, PF4, LIF, STAT5A, JAK2, BMP6
41ovarian cancer29.7IL11, IL3, LIF, JAK2, BMP6
42atherosclerosis29.7TNFRSF11B, BMP6, LIF, AHSG, PF4, FGF2
43glomerulonephritis29.7BMP6
44hypercalcemia29.7LIF, TNFRSF11B
45renal osteodystrophy29.7TNFRSF11B
46adenoma29.7STAT5A, LIF, HMGA2
47down syndrome29.7JAK2, GATA1, FLT3
48tuberculosis29.7IL11, PF4
49acute panmyelosis with myelofibrosis10.4
50acute myeloid leukemia10.4

Graphical network of the top 20 diseases related to Myelofibrosis:



Diseases related to myelofibrosis

Clinical Features for Myelofibrosis

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46OMIM
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Clinical features from OMIM:

254450

Drugs & Therapeutics for Myelofibrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myelofibrosis

Drug clinical trials:

Search ClinicalTrials for Myelofibrosis

Search NIH Clinical Center for Myelofibrosis

Search CenterWatch for Myelofibrosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myelofibrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myelofibrosis:
Peripheral blood-derived hematopoietic stem cells for treatment of myelofibrosis
Embryonic/Adult Cultured Cells Related to Myelofibrosis:
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Myelofibrosis

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22GTR
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Genetic tests related to Myelofibrosis:

id Genetic test Affiliating Genes
1 Myelofibrosis22

Anatomical Context for Myelofibrosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Myelofibrosis:

32
Bone, Bone marrow, Myeloid, Spleen, Liver, T cells, Endothelial, Monocytes, Nk cells, Lung, Prostate, Colon, Whole blood, B cells, Ovary, Spinal cord, Brain, Kidney, Breast, Lymph node, Testes

FMA organs/tissues related to Myelofibrosis:

14
The bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue

Animal Models for Myelofibrosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myelofibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8THPO, TNFRSF11B, JAK2, GATA1, STAT5A, FLT3
2MP:000538410.8STAT5A, GATA1, JAK2, TNFRSF11B, FLT3, MPL
3MP:000537610.8GATA1, STAT5A, FLT3, MPL, LIF, FKBP5
4MP:000537810.7GATA1, JAK2, BMP6, TNFRSF11B, STAT5A, FLT3
5MP:001076810.7FLT3, STAT5A, GATA1, JAK2, TNFRSF11B, MPL
6MP:000538710.7TNFRSF11B, JAK2, GATA1, STAT5A, FLT3, MPL
7MP:001077110.5HMGA2, LIF, GATA1
8MP:000538910.5LIF, BMP6
9MP:000200610.4STAT5A, FLT3, KIT
10MP:000539010.2FGF2, LIF, GATA1, JAK2, TNFRSF11B

Publications for Myelofibrosis

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50PubMed
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Articles related to Myelofibrosis:

(show top 50)    (show all 790)
idTitleAuthorsYear
1
Spinal cord compression due to extramedullary hematopoiesis in a patient with myelofibrosis. (24429645)
2014
2
JAK2 V617F mutation positive primary myelofibrosis with concomitant t(9;11;22)(q34;p15;q11.2) but no BCR/ABL fusion. (23389763)
2013
3
Polyploidy in myelofibrosis: analysis by cytogenetic and SNP array indicates association with advancing disease. (24341401)
2013
4
Successful treatment of a patient with multicentric Castleman's disease who presented with thrombocytopenia, ascites, renal failure and myelofibrosis using tocilizumab, an anti-interleukin-6 receptor antibody. (23812199)
2013
5
The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy. (23599270)
2013
6
JAK2 V617F, MPL W515L and JAK2 Exon 12 Mutations in Chinese Patients with Primary Myelofibrosis. (23359764)
2012
7
Myelofibrosis associated with rickets in a child with Down syndrome. (21913314)
2012
8
Emerging targeted therapies in myelofibrosis. (22780211)
2012
9
European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from prefibrotic primary myelofibrosis. (22058215)
2012
10
Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) - a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia. (20625903)
2011
11
Management of myelofibrosis--where next? (21651445)
2011
12
Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia. (23049357)
2011
13
The JAK2V617F allele burden and STAT3- and STAT5 phosphorylation in myeloproliferative neoplasms: early prefibrotic myelofibrosis compared with essential thrombocythemia, polycythemia vera and myelofibrosis. (21749449)
2011
14
Essential thrombocythemia versus early primary myelofibrosis: a multicenter study to validate the WHO classification. (21447832)
2011
15
Cutaneous lesion of lymphomatoid granulomatosis in a Korean woman with secondary myelofibrosis. (21453314)
2011
16
Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets. (20113333)
2010
17
Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patients. (20567824)
2010
18
Thrombosis in myelofibrosis: prior thrombosis is the only predictive factor and most venous events are provoked. (20884719)
2010
19
A 71-year-old woman with myelofibrosis, hypoxemia, and pulmonary hypertension. (21138888)
2010
20
Extramedullary hematopoiesis and myeloid metaplasia of the ovaries and tubes in a patient with myelofibrosis: case report and concise review of the reported cases. (20697095)
2010
21
International Prognostic Scoring System-independent cytogenetic risk categorization in primary myelofibrosis. (19901264)
2010
22
Successful treatment of severe extremity pain in myelofibrosis with low-dose single-fraction radiation therapy. (20799357)
2010
23
Pulmonary hypertension diagnosed by echocardiography during idiopathic myelofibrosis. A case report and a brief review of the literature. (22958626)
2010
24
Treatment considerations for primary myelofibrosis. (20739724)
2010
25
An interesting case of pachydermoperiostosis with idiopathic myelofibrosis associated with monosomy 22. (19659869)
2009
26
Primary myelofibrosis with concurrent precursor T-cell lymphoblastic lymphoma of the spleen in a 26-year-old patient. (19482354)
2009
27
Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. (19752087)
2009
28
Extramedullary peritoneal hematopoiesis combined with tuberculosis in a patient with primary myelofibrosis. (18850308)
2009
29
Mesenchymal stem cells from JAK2(V617F) mutant patients with primary myelofibrosis do not harbor JAK2 mutant allele. (17706283)
2008
30
Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines. (18349123)
2008
31
Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden. (18451307)
2008
32
Decreased JAK2 V617F allele burden level in a myelofibrosis with myeloid metaplasia patient with leukemic transformation. (18455791)
2008
33
Different involvement of the megakaryocytic lineage by the JAK2 V617F mutation in Polycythemia vera, essential thrombocythemia and chronic idiopathic myelofibrosis. (17262192)
2007
34
Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo. (17077140)
2006
35
Pure red cell aplasia and myelofibrosis in B-cell neoplasm. (16104450)
2005
36
Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia. (16110028)
2005
37
Thalidomide for the treatment of idiopathic myelofibrosis. (14962263)
2004
38
Myelofibrosis with myeloid metaplasia. (14560783)
2003
39
Altered transcription of the stem cell leukemia gene in myelofibrosis with myeloid metaplasia. (14513050)
2003
40
Treatment approaches in myelofibrosis with myeloid metaplasia: the old and the new. (12682877)
2003
41
Esophageal variceal ligation for esophageal variceal hemorrhage in a patient with portal and primary pulmonary hypertension complicating myelofibrosis. (11330433)
2001
42
Multicentric reticulohistiocytosis associated with idiopathic myelofibrosis. (11899135)
2001
43
Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders. (11185990)
2000
44
Successful treatment of acquired myelofibrosis with pure red cell aplasia by cyclosporine. (10050730)
1999
45
Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis. (9156253)
1997
46
Thrombopoietin-responsive essential thrombocythaemia with myelofibrosis. (9163612)
1997
47
The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats. (9432016)
1997
48
Combining interferon-alpha2b (IFN) and intravenous immunoglobulins IgG, IgM and IgA (IVIG) in rapid progressive myelofibrosis (MF) with Trisomy 1. (9092696)
1997
49
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. (8638610)
1996
50
Acute megakaryo-monocytic leukemia with acute myelofibrosis. (8892748)
1996

Genetic Variations for Myelofibrosis

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Expression for genes affiliated with Myelofibrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelofibrosis

Search GEO for disease gene expression data for Myelofibrosis.

Pathways for genes affiliated with Myelofibrosis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Myelofibrosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6BMP6, JAK2, STAT5A, FLT3, LIF, PF4
2
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10.6BMP6, JAK2, STAT5A, FLT3, LIF, PF4
3
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10.6BMP6, JAK2, LIF, PF4, FGF2, IL3
4
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10.6KIT, TNFRSF11B, JAK2, STAT5A, FLT3, MPL
5
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10.6BMP6, JAK2, STAT5A, FLT3, FGF2, IL3
610.6IFNA2, JAK2, STAT5A, MPL, LIF, EPO
710.5IFNA2, JAK2, EPO, FGF2, IL3, KIT
8
Hide members
10.5IFNA2, JAK2, GATA1, MPL, CD177, PF4
9
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10.5BMP6, LIF, FGF2, IL3, KIT, THPO
10
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10.5BMP6, FLT3, FGF2, IL3, KIT, THPO
11
Hide members
10.5BMP6, FLT3, FGF2, IL3, KIT, THPO
1210.5FLT3, EPO, IL3, IL11, KIT, THPO
13
Hide members
10.5JAK2, STAT5A, MPL, THPO
14
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.5JAK2, STAT5A, MPL, THPO
1510.5KIT, FGF2, FLT3, JAK2
16
Hide members
10.5JAK2, STAT5A, EPO, KIT
17
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10.5FLT3, FGF2, KIT, THPO
18
Hide members
10.5KIT, FGF2, STAT5A, JAK2
1910.5JAK2, GATA1, STAT5A, IL3
20
Hide members
10.5THPO, IL3, JAK2
21
Hide members
10.5BMP6, FGF2, IL3, THPO
22
Hide members
10.5IL3, FLT3, STAT5A, JAK2
23
Hide members
10.5IL3, STAT5A, JAK2, IFNA2
24
Development EPO-induced Jak-STAT pathway
Hide members
10.5EPO, STAT5A, JAK2
25
Hide members
10.5MPL, THPO
26
Immune response IL-2 activation and signaling pathway
Hide members
10.5IL3, STAT5A, JAK2
2710.5STAT5A, FGF2, IL3, IL11
28
Hide members
10.5BMP6, THPO

Compounds for genes affiliated with Myelofibrosis

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Myelofibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1MPL, STAT5A, JAK2, BMP6, TNFRSF11B, IFNA2
2vegf4411.0THPO, IL11, FGF2, KIT, PF4, EPO
3gp 1304411.0TNFRSF11B, BMP6, JAK2, STAT5A, FLT3, MPL
4thymidine44 2412.0JAK2, BMP6, IFNA2, STAT5A, PF4, THPO
5retinoic acid44 2412.0JAK2, THPO, HMGA2, IL11, IL3, BMP6
6phosphatidylinositol4411.0FLT3, THPO, KIT, IL11, IL3, FGF2
7cytarabine44 49 1113.0EPO, IL3, IL11, KIT, THPO, LIF
8agar4411.0LIF, MPL, IFNA2, THPO, FGF2, PF4
9methylcellulose4411.0IL11, THPO, FLT3, LIF, EPO, FGF2
10anagrelide44 1112.0IFNA2, JAK2, MPL, EPO, PF4, THPO
11hydroxyurea44 49 1113.0PF4, THPO, GATA1, EPO, IL3, IFNA2
12cyclosporin a44 28 5913.0JAK2, IL3, FGF2, IL11, FKBP5, LIF
13cysteine4411.0IL3, STAT5A, JAK2, MPL, AHSG, PF4
14imatinib44 49 1113.0FLT3, THPO, STAT5A, IL3, JAK2, KIT
15steroid4411.0FKBP5, GATA1, IFNA2, THPO, LIF, STAT5A
16rapamycin4411.0STAT5A, FLT3, JAK2, BMP6, EPO, THPO
17filgrastim44 1111.9THPO, IL11, IL3, EPO, IFNA2, LIF
18tgf beta14410.9IL11, THPO, PF4, TNFRSF11B, FLT3, BMP6
19estrogen4410.9AHSG, THPO, GATA1
20gm-csf44 2811.9THPO, STAT5A, IL11, LIF
21doxorubicin44 49 1112.9HMGA2, KIT, IL11, IL3, GATA1, FLT3
22pixy3214410.9THPO, EPO, IL3, IL11, FLT3
235fluorouracil4410.9THPO, MPL, KIT, IL11, IL3, PF4
24cycloheximide4410.9GATA1, FKBP5
25aspartate4410.9IL11, FLT3, GATA1, STAT5A, BMP6, JAK2
2612-o-tetradecanoylphorbol 13-acetate4410.9GATA1, IFNA2, IL11, IL3, PF4, LIF
27hydrocortisone44 2 59 1113.9FGF2, TNFRSF11B, LIF, STAT5A, EPO
28pd 98,0594410.9STAT5A, JAK2, FGF2, IL3, KIT, BMP6
29ly2940024410.9STAT5A, FGF2, BMP6, IL3, THPO, TNFRSF11B
30herbimycin a44 5911.9IL3, FGF2, BMP6, JAK2, STAT5A, IL11
31alanine4410.9STAT5A, MPL, PF4, JAK2, FGF2, IL3
32dexamethasone44 49 28 1113.9IL3, TNFRSF11B, FKBP5, FGF2, BMP6, LIF
33carboplatin44 49 1112.9THPO, EPO, IL11, IFNA2, LIF, IL3
34actinomycin d4410.9KIT, GATA1, JAK2, LIF, FGF2, IL3
35indomethacin44 59 28 1113.8PF4
36calcitriol44 59 11 2413.8IL11, BMP6, LIF, EPO, TNFRSF11B, IL3
37polyethylene glycol4410.8IFNA2, BMP6, PF4, IL11, THPO, MPL
38progesterone44 59 28 11 2414.8KIT, IL11, FKBP5, LIF, STAT5A, GATA1
39il 114410.8LIF, IL11, EPO, IL3
40azathioprine44 49 2 1113.8TNFRSF11B, IL11, EPO, GATA1, IFNA2, LIF
41rantes4410.7THPO, IL3, PF4, LIF, BMP6, IL11
42lactate4410.7BMP6, FLT3, PF4, LIF, EPO, IL3
43etoposide44 49 59 1113.7IL3, THPO, IFNA2, STAT5A, FLT3, PF4
44oligonucleotide4410.7GATA1, THPO, IL11, KIT, LIF, FLT3
45ascorbic acid44 2411.6LIF, EPO, FGF2, IL3, JAK2, TNFRSF11B
46glucose4410.6AHSG, IFNA2, PF4, IL11, LIF
47sb 20358044 5911.5TNFRSF11B, BMP6, THPO, LIF, STAT5A, JAK2
48butyrate4410.5JAK2, THPO, IL11, GATA1
49ag-12964410.4FLT3, KIT, IL3, STAT5A
50amifostine44 1111.2THPO, IL11, IL3, EPO

GO Terms for genes affiliated with Myelofibrosis

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16Gene Ontology
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Cellular components related to Myelofibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5TNFRSF11B, EPO, AHSG, PF4, FGF2, IL3
2extracellular spaceGO:00561510.3THPO, IFNA2, TNFRSF11B, BMP6, LIF, EPO

Biological processes related to Myelofibrosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828410.9KIT, JAK2, FLT3, LIF, EPO, FGF2
2blood coagulationGO:00759610.9IFNA2, JAK2, GATA1, MPL, CD177, PF4
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9KIT, IL3, EPO, JAK2
4positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9JAK2, GATA1, LIF, IL3, IL11
5positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.9KIT, LIF, JAK2, IFNA2
6peptidyl-tyrosine phosphorylationGO:01810810.9KIT, FLT3, STAT5A, JAK2
7positive regulation of transcription from RNA polymerase II promoterGO:04594410.9BMP6, GATA1, STAT5A, LIF, FGF2, IL11
8cytokine-mediated signaling pathwayGO:01922110.8KIT, PF4, FLT3, JAK2, IFNA2
9positive regulation of MAPK cascadeGO:04341010.8FLT3, LIF, IL11, KIT
10embryonic hemopoiesisGO:03516210.8GATA1, IL3, KIT
11negative regulation of cell proliferationGO:00828510.8JAK2, GATA1, FLT3, LIF, FGF2
12erythrocyte differentiationGO:03021810.8KIT, GATA1, JAK2
13positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.8KIT, FGF2, FLT3
14positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.8KIT, FLT3, JAK2
15tyrosine phosphorylation of Stat3 proteinGO:04250310.8JAK2, LIF
16myeloid progenitor cell differentiationGO:00231810.7FLT3, KIT
17mammary gland epithelium developmentGO:06118010.7STAT5A, JAK2
18platelet activationGO:03016810.7MPL, PF4, IL11, THPO
19positive regulation of phospholipase C activityGO:01086310.7KIT, FGF2
20megakaryocyte differentiationGO:03021910.7IL11, GATA1
21dendritic cell differentiationGO:09702810.6GATA1, FLT3
22positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.6LIF, KIT
23cell-cell signalingGO:00726710.6IFNA2, GATA1, IL3, IL11
24male gonad developmentGO:00858410.5HMGA2, KIT, GATA1
25positive regulation of macrophage differentiationGO:04565110.5LIF, PF4
26cellular response to thyroid hormone stimulusGO:09706710.4KIT, GATA1
27negative regulation of hormone secretionGO:04688810.2LIF, IL11

Molecular functions related to Myelofibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C2H2 zinc finger domain bindingGO:07074210.5HMGA2, GATA1
2cytokine activityGO:00512510.4THPO, IFNA2, TNFRSF11B, BMP6, LIF, FGF2
3growth factor activityGO:00808310.2BMP6, LIF, FGF2, IL3, IL11, THPO

Products for genes affiliated with Myelofibrosis

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  • Antibodies
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Sources for Myelofibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet