MCID: MYL005
MIFTS: 68

Myelofibrosis malady

Genetic diseases, Rare diseases, Blood diseases, Cancer diseases, Bone diseases, Immune diseases categories

Aliases & Classifications for Myelofibrosis

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Myelofibrosis, Aliases & Descriptions:

Name: Myelofibrosis 30 9 41 11 43 22 60
Primary Myelofibrosis 9 41 21 43 47 60
Agnogenic Myeloid Metaplasia 9 41 21 43 47
Idiopathic Myelofibrosis 41 21 43 47
Myeloid Metaplasia 41 21 43 60
Myelofibrosis with Myeloid Metaplasia 41 21 47
 
Myelosclerosis with Myeloid Metaplasia 41 47
Megakaryocytic Myelosclerosis 9 60
Chronic Idiopathic Myelofibrosis 21
Bone Marrow Fibrosis 9
Aleukemic Myelosis 9
Myelosclerosis 9


Classifications:



Characteristics (Orphanet epidemiological data):

47
primary myelofibrosis:
Prevalence: 1-9/100000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:4971
NCIt38 C2862
MeSH33 D055728
ICD9CM27 238.76
Orphanet47 824
ICD10 via Orphanet26 D47.4

Summaries for Myelofibrosis

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NIH Rare Diseases:41 Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue. scarring of the bone marrow causes anemia, which can lead to fatigue and weakness, as well as pooling of the blood in abnormal sites like the liver and spleen, causing these organs to swell. although myelofibrosis can occur at any age, it typically develops after the age of 50. in most cases, myelofibrosis gets progressively worse. treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.    last updated: 8/17/2011

MalaCards based summary: Myelofibrosis, also known as primary myelofibrosis, is related to polycythemia and myelofibrosis with myeloid metaplasia, somatic. An important gene associated with Myelofibrosis is SH2B3 (SH2B adaptor protein 3), and among its related pathways are Growth hormone receptor signaling and Immune response Oncostatin M signaling via JAK Stat in human cells. The drug busulfan and the compounds filgrastim and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue, bone and bone marrow, and related mouse phenotypes are tumorigenesis and integument.

Disease Ontology:9 A myeloma that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.

Genetics Home Reference:21 Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. Because of the fibrosis, the bone marrow is unable to make enough normal blood cells. The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis.

Wikipedia:63 Myelofibrosis, also known as osteomyelofibrosis, is a rare bone marrow cancer. It is currently... more...

Related Diseases for Myelofibrosis

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Diseases in the Myelofibrosis family:

Familial Myelofibrosis

Diseases related to Myelofibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia31.4EPO, MPL, THPO, JAK2, STAT5A, CD177
2myelofibrosis with myeloid metaplasia, somatic31.2SH2B3, JAK2
3leukemoid reaction31.2GATA1, IL3
4splenomegaly31.1THPO, MPL, EPO, JAK2, IFNA2
5pancytopenia30.8THPO, MPL, EPO, IL3
6systemic mastocytosis30.8TET2
7chronic myeloproliferative disease30.8THPO, MPL, JAK2
8megakaryocytic leukemia30.8THPO, PF4, IL3, GATA1
9chronic myelomonocytic leukemia30.8MPL, JAK2, STAT5A, KIT
10essential thrombocythemia30.7PF4, MPL, THPO, EPO, JAK2, CD177
11sarcoma30.7HMGA2, KIT, JAK2, THPO
12hypersplenism30.7THPO
13myeloid leukemia30.6THPO, MPL, JAK2, STAT5A, IL3, BMP6
14myelodysplastic syndrome30.6CD177, GATA1, KIT, IL3, STAT5A, JAK2
15obesity30.5AHSG, JAK2, STAT5A
16thrombocytopenia30.4THPO, MPL, PF4, EPO, IFNA2, IL3
17uremia30.4AHSG, TNFRSF11B, PF4, EPO
18refractory anemia30.3THPO, MPL, EPO, JAK2, IL3, KIT
19polyarteritis nodosa30.3IFNA2
20polycythemia vera30.3CD177, HMGA2, KIT, IL3, IFNA2, STAT5A
21aplastic anemia30.2THPO, MPL, EPO, IL3, GATA1
22thrombocytosis30.2CD177, IL3, IFNA2, JAK2, EPO, PF4
23leukemia30.0KIT, BMP6, IL3, IFNA2, STAT5A, JAK2
24neutropenia30.0THPO, MPL, EPO, IFNA2, IL3, CD177
25myeloma29.9TNFRSF11B, PF4, EPO, JAK2, STAT5A, IFNA2
26breast cancer29.9FGF2, GATA1, CALR, BMP6, JAK2
27deficiency anemia29.9THPO, MPL, EPO, JAK2, IFNA2, IL3
28rheumatoid arthritis29.9THPO, TNFRSF11B, PF4, JAK2, BMP6, CALR
29atherosclerosis29.9AHSG, TNFRSF11B, PF4, BMP6, FGF2
30acute leukemia29.8THPO, MPL, EPO, JAK2, STAT5A, IL3
31adenocarcinoma29.6PF4, JAK2, STAT5A, BMP6, CALR, HMGA2
32acute panmyelosis with myelofibrosis10.6
33purpura10.6THPO
34arteriovenous fistula10.5EPO
35erythrocytosis, somatic10.5SH2B3, JAK2
36acquired polycythemia10.5EPO, JAK2
37bone marrow cancer10.5MPL, JAK2
38thrombocytopenia due to platelet alloimmunization10.5THPO, MPL
39thrombocytopenia, x-linked10.5GATA1, THPO
40diamond-blackfan anemia10.5EPO, IL3
41bronchiolitis obliterans10.5BMP6
42thrombocytopenia, congenital amegakaryocytic10.4IL3, MPL, THPO
43hypereosinophilic syndrome, idiopathic, resistant to imatinib10.4KIT, IL3
44severe congenital neutropenia10.4THPO, JAK2, IL3
45primary polycythemia10.4EPO, JAK2, STAT5A
46intermittent claudication10.4PF4, FGF2
47dedifferentiated liposarcoma10.4HMGA2, KIT
48iron deficiency anemia10.4EPO, THPO
49thrombocytopenic purpura, autoimmune10.4THPO, MPL, IFNA2
50corneal neovascularization10.4FGF2, PF4

Graphical network of the top 20 diseases related to Myelofibrosis:



Diseases related to myelofibrosis

Symptoms for Myelofibrosis

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Drugs & Therapeutics for Myelofibrosis

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Drug clinical trials:

Search ClinicalTrials for Myelofibrosis

Search NIH Clinical Center for Myelofibrosis

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Myelofibrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myelofibrosis:
Peripheral blood-derived hematopoietic stem cells for treatment of myelofibrosis
Embryonic/Adult Cultured Cells Related to Myelofibrosis:
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Myelofibrosis

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Genetic tests related to Myelofibrosis:

id Genetic test Affiliating Genes
1 Myelofibrosis22

Anatomical Context for Myelofibrosis

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MalaCards organs/tissues related to Myelofibrosis:

31
Bone, Bone marrow, Myeloid, Spleen, Liver, T cells, Endothelial, Monocytes, Whole blood, Nk cells, Neutrophil, Colon, Lung, Prostate, B cells, Lymph node, Brain, Spinal cord, Kidney, Breast, Ovary, Testes

FMA organs/tissues related to Myelofibrosis:

14
The bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue

Animal Models for Myelofibrosis or affiliated genes

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Publications for Myelofibrosis

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Articles related to Myelofibrosis:

(show top 50)    (show all 843)
idTitleAuthorsYear
1
Mutations and long-term outcome of 217 young patients with essential thrombocythemia or early primary myelofibrosis. (25801912)
2015
2
Durable remission with rituximab in a patient with an unusual variant of Castleman's disease with myelofibrosis -TAFRO syndrome. (25808231)
2015
3
Response to ruxolitinib in patients with intermediate-1-, intermediate-2-, and high-risk myelofibrosis: results of the UK ROBUST Trial. (25824940)
2015
4
Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis. (25037629)
2014
5
Efficacy and safety of ruxolitinib in Asian patients with myelofibrosis. (25315076)
2014
6
SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. (23558523)
2013
7
Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosis. (24176039)
2013
8
Reversible bone marrow aplasia induced by pegylated interferon-I+-2a therapy in a patient with primary myelofibrosis. (24067929)
2013
9
Chromosome 5q deletion is extremely rare in patients with myelofibrosis. (23391517)
2013
10
Myelofibrosis in Philadelphia chromosome-negative myeloproliferative neoplasms is associated with aberrant karyotypes. (23571153)
2013
11
Lymphodepletion chemotherapy followed by donor leukocytes for post-transplantation relapse of myelofibrosis after previous donor leukocyte infusion failure. (23110685)
2013
12
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management. (23349007)
2013
13
The relationship of the active and latent forms of TGF-I^1 with marrow fibrosis in essential thrombocythemia and primary myelofibrosis. (22200991)
2012
14
Myelofibrosis: a cause of increased transfusion requirement in a child with I^-thalassemia intermedia. (22009011)
2012
15
Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis--an entity different from adults. (22389089)
2012
16
Guideline for the diagnosis and management of myelofibrosis. (22651893)
2012
17
JAK2 V617F, MPL W515L and JAK2 Exon 12 Mutations in Chinese Patients with Primary Myelofibrosis. (23359764)
2012
18
GR SNP helps transform myelofibrosis. (23065009)
2012
19
Evaluating the serial use of the Myelofibrosis Symptom Assessment Form for measuring symptomatic improvement: performance in 87 myelofibrosis patients on a JAK1 and JAK2 inhibitor (INCB018424) clinical trial. (21480207)
2011
20
Ruxolitinib for the treatment of myelofibrosis. (22146225)
2011
21
Bone marrow fibrosis in myeloproliferative neoplasms-associated myelofibrosis: deconstructing a myth? (21296418)
2011
22
The surgical palliative treatment of myelofibrosis. Personal experience. (21682106)
2011
23
Improved outcomes using tacrolimus/sirolimus for graft-versus-host disease prophylaxis with a reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplant as treatment of myelofibrosis. (19786111)
2010
24
Pyoderma gangrenosum associated with chronic idiopathic myelofibrosis after coronary artery bypass graft surgery. (19846444)
2010
25
Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets. (20113333)
2010
26
Thrombosis in primary myelofibrosis: incidence and risk factors. (19965680)
2010
27
Toxic epidermal necrolysis in a patient with primary myelofibrosis receiving thalidomide therapy. (19052692)
2009
28
Lenalidomide plus prednisone results in durable clinical, histopathologic, and molecular responses in patients with myelofibrosis. (19720904)
2009
29
Massive eyelid thickening in pachydermoperiostosis with myelofibrosis. (19617796)
2009
30
JAK2(V617F) allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis. (19616600)
2009
31
The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea. (18266209)
2008
32
Plasma cell leukemia with myelofibrosis. (19039200)
2008
33
Myelofibrosis in a child with EBV-associated hemophagocytic lymphohistiocytosis. (18454467)
2008
34
A higher JAK2 V617F-mutated clone is observed in platelets than in granulocytes from essential thrombocythemia patients, but not in patients with polycythemia vera and primary myelofibrosis. (17361221)
2007
35
Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis, advanced polycythemia vera, and essential thrombocythemia. (17317589)
2007
36
No influence of V617F mutation in JAK2 on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for myelofibrosis. (17162218)
2006
37
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. (16834459)
2006
38
Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia. (15755503)
2005
39
A patient with TP53 germline mutation developed Bowen's disease and myelodysplastic syndrome with myelofibrosis after chemotherapy against ovarian cancer. (15942101)
2005
40
Acute panmyelosis with myelofibrosis: clinical, immunophenotypic and cytogenetic study of twelve cases. (15223649)
2004
41
Systemic lupus erythematosus presenting with pancytopenia due to bone marrow myelofibrosis in a 22-year-old male. (16163223)
2004
42
Impaired NK cell differentiation of blood-derived CD34+ progenitors from patients with myeloid metaplasia with myelofibrosis. (12706407)
2003
43
SU6668 in idiopathic myelofibrosis--a rational therapeutic approach targeting several tyrosine kinases of importance for the myeloproliferation and the development of bone marrow fibrosis and angiogenesis. (12888313)
2003
44
Lack of alteration in GATA-1 expression in CD34+ hematopoietic progenitors from patients with idiopathic myelofibrosis. (12788793)
2003
45
The therapy of myelofibrosis: targeting pathogenesis. (12430941)
2002
46
Esophageal variceal ligation for esophageal variceal hemorrhage in a patient with portal and primary pulmonary hypertension complicating myelofibrosis. (11330433)
2001
47
Erythroleukemia following erythropoietin therapy, extramedullary hematopoiesis, and splenectomy in a patient with myelofibrosis and myeloid metaplasia. (11391725)
2001
48
Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis. (10550553)
1999
49
Laparoscopically assisted splenectomy following preoperative splenic artery embolization using contour emboli for myelofibrosis with massive splenomegaly. (10804000)
1999
50
Myelofibrosis secondary to renal osteodystrophy. (8730443)
1996

Variations for Myelofibrosis

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Clinvar genetic disease variations for Myelofibrosis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1SH2B3NM_005475.2(SH2B3): c.603_607delGCGCT (p.Arg202Glnfs)deletionPathogenicGRCh37Chr 12, 111856552: 111856556

Expression for genes affiliated with Myelofibrosis

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Search GEO for disease gene expression data for Myelofibrosis.

Pathways for genes affiliated with Myelofibrosis

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Pathways related to Myelofibrosis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9JAK2, STAT5A
29.9STAT5A, JAK2
39.9STAT5A, JAK2
49.9FGF2, KIT, JAK2
59.8KIT, GATA1, IL3
6
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.7JAK2, STAT5A, FGF2
7
Show member pathways
9.7JAK2, STAT5A, IL3
8
Show member pathways
Immune response IL 3 activation and signaling pathway58
9.7IL3, JAK2, STAT5A
9
Show member pathways
9.7IL3, STAT5A, JAK2
109.7GATA1, IFNA2, JAK2, SH2B3
119.6THPO, EPO, IL3, KIT
12
Show member pathways
EPO Receptor Signaling36
EPO signaling pathway36
9.6SH2B3, JAK2, STAT5A, EPO
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.6STAT5A, JAK2, THPO, MPL
14
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.6MPL, THPO, JAK2, STAT5A
15
Show member pathways
9.6STAT5A, JAK2, MPL, FGF2
169.5IL3, JAK2, STAT5A, GATA1
17
Show member pathways
9.5THPO, IL3, BMP6, FGF2
18
Show member pathways
9.4STAT5A, IFNA2, IL3, JAK2
19
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.4STAT5A, JAK2, EPO, KIT, SH2B3
20
Show member pathways
9.4SH2B3, STAT5A, FGF2, JAK2, KIT
21
Show member pathways
9.3THPO, IL3, BMP6, KIT, FGF2
22
Show member pathways
9.3FGF2, THPO, IL3, BMP6, KIT
23
Show member pathways
9.3BMP6, FGF2, THPO, IL3, KIT
24
Show member pathways
9.3THPO, IL3, BMP6, FGF2, KIT
25
Show member pathways
9.3IL3, BMP6, KIT, FGF2, THPO
269.2IL3, IFNA2, EPO, KIT, JAK2, FGF2
27
Show member pathways
9.1THPO, JAK2, IL3, KIT, FGF2, BMP6
28
Show member pathways
Type III interferon signaling36
9.1EPO, JAK2, STAT5A, IFNA2, IL3, MPL
29
Show member pathways
8.7JAK2, THPO, IL3, KIT, FGF2, BMP6
30
Show member pathways
8.7PF4, JAK2, FGF2, THPO, IL3, BMP6
31
Show member pathways
8.7SH2B3, CD177, PF4, GATA1, IFNA2, JAK2
32
Show member pathways
8.3KIT, THPO, FGF2, BMP6, IL3, STAT5A
33
Show member pathways
8.3FGF2, THPO, PF4, JAK2, KIT, STAT5A
34
Show member pathways
8.1IL3, FGF2, KIT, BMP6, IFNA2, STAT5A
35
Show member pathways
7.8IL3, KIT, BMP6, MPL, IFNA2, STAT5A

Compounds for genes affiliated with Myelofibrosis

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Compounds related to Myelofibrosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1filgrastim43 1210.9THPO, EPO, IFNA2, IL3
2methylcellulose439.8IL3, KIT, THPO, EPO, FGF2
3bleomycin43 1210.6EPO, IFNA2, FGF2, BMP6, CALR
4gm-csf43 2810.5STAT5A, THPO, BMP6, EPO, IL3
5anagrelide43 1210.5THPO, IFNA2, JAK2, EPO, PF4, MPL
6polyethylene glycol439.3PF4, THPO, MPL, IFNA2, BMP6
7actinomycin d439.3THPO, FGF2, GATA1, KIT, IL3, HMGA2
8chondroitin sulfate43 2410.3BMP6, PF4, TNFRSF11B, THPO, FGF2
95fluorouracil439.3KIT, PF4, THPO, IFNA2, MPL, IL3
10ascorbic acid43 2410.3FGF2, TNFRSF11B, IL3, EPO, JAK2, IFNA2
11vincristine43 49 1211.3BMP6, IFNA2, IL3, KIT, FGF2
12iron43 2410.2GATA1, THPO, MPL, EPO, IFNA2, CALR
13cytarabine43 49 1211.2STAT5A, IL3, KIT, GATA1, EPO, THPO
14aspirin43 49 28 2412.2THPO, TNFRSF11B, MPL, PF4, JAK2, BMP6
15hydrocortisone43 2 59 1212.2BMP6, EPO, STAT5A, IL3, TNFRSF11B, FGF2
16imatinib43 49 1211.2BMP6, JAK2, EPO, THPO, KIT, STAT5A
17butyrate439.2GATA1, IL3, JAK2, EPO, BMP6, THPO
18vitamin d439.1BMP6, CALR, GATA1, TNFRSF11B, EPO, AHSG
19pd 98,059439.1KIT, THPO, JAK2, STAT5A, IL3, BMP6
20lysine439.0PF4, IFNA2, CALR, MPL, TNFRSF11B, THPO
21hydroxyurea43 49 1211.0KIT, IFNA2, JAK2, EPO, PF4, THPO
22tgf beta1439.0BMP6, PF4, TNFRSF11B, THPO, FGF2
2312-o-tetradecanoylphorbol 13-acetate439.0JAK2, IFNA2, PF4, IL3, BMP6, GATA1
24sb 20358043 5910.0STAT5A, FGF2, THPO, JAK2, BMP6, TNFRSF11B
25histamine43 28 2411.0IFNA2, KIT, PF4, THPO, IL3, BMP6
26lactate438.9KIT, THPO, PF4, EPO, IL3, CALR
27rapamycin438.9THPO, JAK2, STAT5A, IL3, FKBP5, BMP6
28doxorubicin43 49 1210.9TNFRSF11B, HMGA2, GATA1, KIT, IFNA2, IL3
29ly294002438.9EPO, JAK2, STAT5A, IL3, BMP6, FGF2
30polysaccharide438.8THPO, PF4, IL3, BMP6, CALR, FGF2
31heparin43 28 24 1211.8BMP6, IL3, PF4, FGF2, CALR, THPO
32cyclosporin a43 28 5910.8FGF2, JAK2, EPO, TNFRSF11B, FKBP5, STAT5A
33indomethacin43 28 59 1211.8JAK2, STAT5A, IFNA2, THPO, BMP6, PF4
34aspartate438.8IFNA2, EPO, KIT, GATA1, BMP6, TNFRSF11B
35gp 130438.7EPO, MPL, JAK2, STAT5A, IL3, KIT
36dexamethasone43 49 28 1211.6IL3, FKBP5, THPO, TNFRSF11B, STAT5A, FGF2
37cycloheximide438.6TNFRSF11B, JAK2, FKBP5, STAT5A, BMP6, KIT
38agar438.5STAT5A, JAK2, IFNA2, MPL, THPO, IL3
39alanine438.5MPL, FGF2, BMP6, IL3, IFNA2, JAK2
40glucose438.4AHSG, THPO, TNFRSF11B, PF4, JAK2, STAT5A
41phosphatidylinositol438.3BMP6, KIT, FGF2, MPL, TNFRSF11B, STAT5A
42steroid438.3THPO, PF4, JAK2, FKBP5, STAT5A, TNFRSF11B
43thymidine43 249.3JAK2, IL3, FGF2, STAT5A, IFNA2, PF4
44serine438.3MPL, STAT5A, CALR, BMP6, JAK2, KIT
45progesterone43 28 59 24 1212.2TNFRSF11B, FKBP5, STAT5A, IFNA2, BMP6, KIT
46estrogen438.1AHSG, FGF2, KIT, IFNA2, JAK2, STAT5A
47cysteine438.1KIT, IFNA2, TNFRSF11B, IL3, THPO, AHSG
48retinoic acid43 248.9GATA1, IL3, TNFRSF11B, JAK2, STAT5A, IFNA2
49vegf437.8FGF2, IFNA2, BMP6, KIT, GATA1, JAK2
50tyrosine437.0MPL, PF4, EPO, JAK2, STAT5A, IFNA2

GO Terms for genes affiliated with Myelofibrosis

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Cellular components related to Myelofibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.4TNFRSF11B, PF4, EPO, IFNA2, IL3, CALR
2extracellular spaceGO:00056157.3FGF2, THPO, AHSG, TNFRSF11B, PF4, EPO

Biological processes related to Myelofibrosis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:001086310.4FGF2, KIT
2negative regulation of intracellular steroid hormone receptor signaling pathwayGO:003314410.3HMGA2, CALR
3cellular response to thyroid hormone stimulusGO:009706710.3GATA1, KIT
4erythrocyte differentiationGO:003021810.2JAK2, KIT, GATA1
5mammary gland epithelium developmentGO:006118010.2STAT5A, JAK2
6myeloid cell differentiationGO:003009910.2THPO, TET2
7negative regulation of bone mineralizationGO:003050210.2AHSG, GATA1
8positive regulation of DNA replicationGO:004574010.2CALR, IL3, EPO
9chaperone-mediated protein foldingGO:006107710.2CALR, FKBP5
10positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.2JAK2, IL3, GATA1
11positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2JAK2, IFNA2, KIT
12stem cell differentiationGO:004886310.1KIT, HMGA2
13response to testosteroneGO:003357410.1EPO, CALR
14positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.1JAK2, KIT, HMGA2
15positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1KIT, IL3, JAK2, EPO
16embryonic hemopoiesisGO:003516210.1SH2B3, IL3, KIT, GATA1
17response to magnesium ionGO:003202610.0BMP6, TNFRSF11B
18male gonad developmentGO:000858410.0KIT, HMGA2, GATA1
19positive regulation of phagocytosisGO:005076610.0CALR, AHSG
20peptidyl-tyrosine phosphorylationGO:001810810.0KIT, STAT5A, JAK2
21JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.8STAT5A, JAK2
22response to axon injuryGO:00486789.8EPO, FGF2
23skeletal system developmentGO:00015019.7BMP6, TNFRSF11B, AHSG
24cytokine-mediated signaling pathwayGO:00192219.7PF4, JAK2, IFNA2, KIT
25positive regulation of gene expressionGO:00106289.7HMGA2, KIT, CALR, PF4
26positive regulation of cell proliferationGO:00082849.7EPO, JAK2, IL3, CALR, KIT, FGF2
27negative regulation of transcription, DNA-templatedGO:00458929.6IFNA2, CALR, HMGA2, FGF2
28signal transductionGO:00071659.4TNFRSF11B, EPO, JAK2, KIT, HMGA2, FGF2
29blood coagulationGO:00075969.1CD177, THPO, SH2B3, MPL, PF4, JAK2
30positive regulation of transcription from RNA polymerase II promoterGO:00459448.8TET2, PF4, STAT5A, BMP6, HMGA2, GATA1

Molecular functions related to Myelofibrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1C2H2 zinc finger domain bindingGO:007074210.0GATA1, HMGA2
2growth factor activityGO:00080839.4THPO, IL3, BMP6, FGF2
3cytokine activityGO:00051258.9FGF2, BMP6, IL3, IFNA2, TNFRSF11B, THPO
4protein bindingGO:00055157.7TET2, SH2B3, EPO, JAK2, STAT5A, IFNA2

Products for genes affiliated with Myelofibrosis

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Sources for Myelofibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet