MCID: MYL005
MIFTS: 75

Myelofibrosis malady

Bone diseases, Immune diseases categories

Summaries for Myelofibrosis

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue. scarring of the bone marrow causes anemia, which can lead to fatigue and weakness, as well as pooling of the blood in abnormal sites like the liver and spleen, causing these organs to swell. although myelofibrosis can occur at any age, it typically develops after the age of 50. in most cases, myelofibrosis gets progressively worse. treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.    last updated: 8/17/2011

MalaCards: Myelofibrosis, also known as primary myelofibrosis, is related to leukemia and polycythemia. An important gene associated with Myelofibrosis is JAK2 (Janus kinase 2), and among its related pathways are Rho Family GTPases and Akt Signaling. The drug busulfan and the compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue, bone and bone marrow, and related mouse phenotypes are hematopoietic system and cellular.

Disease Ontology:8 A myeloma that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.

Genetics Home Reference:21 Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. Because of the fibrosis, the bone marrow is unable to make enough normal blood cells. The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis.

Wikipedia:63 Myelofibrosis, also known as myeloid metaplasia, chronic idiopathic myelofibrosis, osteomyelofibrosis... more...

Description from OMIM:46 254450

Aliases & Classifications for Myelofibrosis

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 21Genetics Home Reference, 34MeSH, 56SNOMED-CT, 46OMIM, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

myelofibrosis 8 42 22 10 44 30 60
primary myelofibrosis 8 42 21 44 60
agnogenic myeloid metaplasia 8 42 21 44
myeloid metaplasia 42 21 44 60
idiopathic myelofibrosis 42 21 44
chronic idiopathic myelofibrosis 8 21
megakaryocytic myelosclerosis 8 60
myelofibrosis with myeloid metaplasia 21
idiopathic bone marrow fibrosis 8
bone marrow fibrosis 8
myelosclerosis, nos 8
aleukemic myelosis 8
myelosclerosis 8


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Disease Ontology8 DOID:4971
MeSH34 D055728
OMIM46 254450
ICD9CM27 238.76
NCIt39 C2862

Related Diseases for Myelofibrosis

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17GeneCards, 18GeneDecks
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Diseases in the Myelofibrosis family:

Familial Myelofibrosis

Diseases related to Myelofibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.1IFNA2, BMP6, JAK2, GATA1, STAT5A, THPO
2polycythemia31.1CD177, EPO, IL3, THPO, MPL, STAT5A
3polycythemia vera31.1IFNA2, JAK2, STAT5A, FLT3, MPL, CD177
4acute leukemia30.9THPO, KIT, JAK2, GATA1, STAT5A, FLT3
5primary polycythemia30.8JAK2, STAT5A, EPO
6myeloid leukemia30.6FLT3, MPL, LIF, IL3, IL11, KIT
7osteosclerosis30.6TNFRSF11B, THPO
8thrombocytosis30.4THPO, IL11, IFNA2, JAK2, FLT3, MPL
9vascular disease30.4FGF2, PF4, JAK2
10leukemoid reaction30.4IL3, GATA1
11thrombocytopenia30.3IFNA2, GATA1, MPL, EPO, PF4, IL3
12sarcoma30.3JAK2, KIT, HMGA2, THPO
13megakaryocytic leukemia30.3GATA1, PF4, IL3, IL11, THPO
14pancytopenia30.2THPO, IL3, EPO, MPL
15hepatitis30.2IFNA2, AHSG
16myeloma30.2IFNA2, TNFRSF11B, JAK2, STAT5A, LIF, EPO
17multiple myeloma30.2TNFRSF11B
18obesity30.1JAK2, STAT5A, LIF, AHSG
19uremia30.1TNFRSF11B, EPO, AHSG, PF4
20chronic myeloid leukemia30.1GATA1, STAT5A, FLT3, MPL, CD177, EPO
21chronic myeloproliferative disease30.1JAK2, FLT3, MPL, THPO
22arthritis30.1FGF2, LIF, TNFRSF11B
23peritonitis30.1LIF
24hairy cell leukemia30.1IL3, FLT3, IFNA2
25monocytic leukemia30.1GATA1, LIF
26myeloid sarcoma30.1FLT3, KIT
27hyperparathyroidism30.1TNFRSF11B, EPO
28beta thalassemia30.0EPO, GATA1, TNFRSF11B
29acute lymphocytic leukemia29.9JAK2, GATA1, FLT3, MPL, IL3, KIT
30rheumatoid arthritis29.9TNFRSF11B, BMP6, JAK2, LIF, PF4, IL11
31systemic mastocytosis29.9IFNA2, JAK2, STAT5A, KIT
32hypersplenism29.9THPO
33hepatitis b29.9IFNA2
34hemorrhagic thrombocythemia29.9CD177
35porphyria29.9GATA1
36deficiency anemia29.7THPO, IFNA2, JAK2, GATA1, FLT3, MPL
37breast cancer29.7TNFRSF11B, BMP6, JAK2, STAT5A, FLT3, LIF
38neutropenia29.7IL3, IL11, THPO, EPO, CD177, LIF
39aplastic anemia29.7GATA1, FLT3, MPL, EPO, IL3, IL11
40adenocarcinoma29.7HMGA2, PF4, LIF, STAT5A, JAK2, BMP6
41ovarian cancer29.7IL11, IL3, LIF, JAK2, BMP6
42atherosclerosis29.7TNFRSF11B, BMP6, LIF, AHSG, PF4, FGF2
43glomerulonephritis29.7BMP6
44hypercalcemia29.7LIF, TNFRSF11B
45renal osteodystrophy29.7TNFRSF11B
46adenoma29.7STAT5A, LIF, HMGA2
47down syndrome29.7JAK2, GATA1, FLT3
48tuberculosis29.7IL11, PF4
49acute panmyelosis with myelofibrosis10.4
50acute myeloid leukemia10.4

Graphical network of the top 20 diseases related to Myelofibrosis:



Diseases related to myelofibrosis

Clinical Features for Myelofibrosis

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46OMIM
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Clinical features from OMIM:

254450

Drugs & Therapeutics for Myelofibrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myelofibrosis

Drug clinical trials:

Search ClinicalTrials for Myelofibrosis

Search NIH Clinical Center for Myelofibrosis

Search CenterWatch for Myelofibrosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myelofibrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myelofibrosis:
Peripheral blood-derived hematopoietic stem cells for treatment of myelofibrosis
Embryonic/Adult Cultured Cells Related to Myelofibrosis:
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Myelofibrosis

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22GTR
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Genetic tests related to Myelofibrosis:

id Genetic test Affiliating Genes
1 Myelofibrosis22

Anatomical Context for Myelofibrosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Myelofibrosis:

32
Bone, Bone marrow, Myeloid, Spleen, Liver, T cells, Endothelial, Monocytes, Nk cells, B cells, Prostate, Lung, Whole blood, Colon, Breast, Lymph node, Brain, Spinal cord, Testes, Kidney, Ovary

FMA organs/tissues related to Myelofibrosis:

14
The bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue

Animal Models for Myelofibrosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myelofibrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.8THPO, TNFRSF11B, JAK2, GATA1, STAT5A, FLT3
2MP:000538410.8STAT5A, GATA1, JAK2, TNFRSF11B, FLT3, MPL
3MP:000537610.8GATA1, STAT5A, FLT3, MPL, LIF, FKBP5
4MP:000537810.7GATA1, JAK2, BMP6, TNFRSF11B, STAT5A, FLT3
5MP:001076810.7FLT3, STAT5A, GATA1, JAK2, TNFRSF11B, MPL
6MP:000538710.7TNFRSF11B, JAK2, GATA1, STAT5A, FLT3, MPL
7MP:001077110.5HMGA2, LIF, GATA1
8MP:000538910.5LIF, BMP6
9MP:000200610.4STAT5A, FLT3, KIT
10MP:000539010.2FGF2, LIF, GATA1, JAK2, TNFRSF11B

Publications for Myelofibrosis

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50PubMed
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Articles related to Myelofibrosis:

(show top 50)    (show all 790)
idTitleAuthorsYear
1
Lymphodepletion chemotherapy followed by donor leukocytes for post-transplantation relapse of myelofibrosis after previous donor leukocyte infusion failure. (23110685)
2013
2
Allogeneic hematopoietic stem cell transplantation for infants with idiopathic myelofibrosis. (24102929)
2013
3
SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis. (23660863)
2013
4
The ERCC2 Gln/Gln polymorphism at codon 751 is not associated with leukaemic transformation in primary myelofibrosis. (23672414)
2013
5
CD14(bright)CD16(low) intermediate monocytes expressing Tie2 are increased in the peripheral blood of patients with primary myelofibrosis. (24333662)
2013
6
Primary myelofibrosis: when the clone manifests with Rh phenotype splitting. (24149913)
2013
7
U2AF1 mutations in primary myelofibrosis are strongly associated with anemia and thrombocytopenia despite clustering with JAK2V617F and normal karyotype. (24097336)
2013
8
The role of cytokines in the initiation and progression of myelofibrosis. (23415024)
2013
9
Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis. (23373780)
2013
10
A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF). (23330839)
2013
11
Ruxolitinib for the treatment of myelofibrosis: a NICE single technology appraisal. (23996108)
2013
12
Restoration of response to ruxolitinib upon brief withdrawal in two patients with myelofibrosis. (24273107)
2013
13
Prognostic implications and clinical characteristics associated with bone marrow fibrosis in patients with myelofibrosis. (23343175)
2013
14
The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation. (22234678)
2012
15
Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis. (22300941)
2012
16
Autopsy case of primary myelofibrosis in which myeloid sarcoma was the initial manifestation of tumor progression. (22612514)
2012
17
IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F. (21912393)
2012
18
Spleens of myelofibrosis patients contain malignant hematopoietic stem cells. (23023702)
2012
19
Management of myelofibrosis: a survey of current practice in the United Kingdom. (22944622)
2012
20
Advances in the management of myelofibrosis. (23042420)
2012
21
Red blood cell transfusion-dependency implies a poor survival in primary myelofibrosis irrespective of IPSS and DIPSS. (20884708)
2011
22
Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. (21712540)
2011
23
Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis. (21447007)
2011
24
Improved outcomes using tacrolimus/sirolimus for graft-versus-host disease prophylaxis with a reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplant as treatment of myelofibrosis. (19786111)
2010
25
JAK inhibition in myelofibrosis. (21158663)
2010
26
Therapeutic options for patients with myelofibrosis in blast phase. (20627294)
2010
27
Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation. (20005966)
2010
28
Successful control of acute myelofibrosis with lenalidomide. (21274282)
2010
29
Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis. (21030572)
2010
30
The role of splenectomy in myelofibrosis with myeloid metaplasia. (21224796)
2010
31
Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells. (20858855)
2010
32
Allogeneic hematopoietic cell transplantation for myelofibrosis: a 10-year experience at single institution. (20890908)
2010
33
Primary myelofibrosis in a patient who developed primary biliary cirrhosis, autoimmune hemolytic anemia and fibrillary glomerulonephritis. (18575863)
2008
34
Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease. (18206727)
2008
35
A higher JAK2 V617F-mutated clone is observed in platelets than in granulocytes from essential thrombocythemia patients, but not in patients with polycythemia vera and primary myelofibrosis. (17361221)
2007
36
Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time. (17107350)
2006
37
High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension. (16418333)
2006
38
Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis. (15927672)
2005
39
Bone marrow expression of vascular endothelial growth factor in myelofibrosis with myeloid metaplasia. (15613104)
2005
40
Hairy cell leukemia (HCL) with extensive myelofibrosis responds to thalidomide. (15978949)
2005
41
Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia. (15578075)
2005
42
Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF). (15621770)
2004
43
Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L. (9864154)
1999
44
Myelofibrosis: experimental models and human studies. (11012187)
1998
45
Improvement of erythropoiesis during treatment with deferiprone in a patient with myelofibrosis and transfusional hemosiderosis. (8619408)
1996
46
Plasma cell leukemia with myelofibrosis. (8086511)
1994
47
Establishment of a novel granulocytic sarcoma cell line which can adhere to dermal fibroblasts from a patient with granulocytic sarcoma in dermal tissues and myelofibrosis. (1419799)
1992
48
Acquired hemoglobin H disease associated with idiopathic myelofibrosis and hereditary adenosine deaminase deficiency. (7415771)
1980
49
Periostitis associated with myelofibrosis. (87252)
1979
50
Nodular regenerative hyperplasia of the liver in a case of myelofibrosis with extramedullary hematopoiesis and secondary portal venous hypertension. (453099)
1979

Genetic Variations for Myelofibrosis

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Expression for genes affiliated with Myelofibrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myelofibrosis

Search GEO for disease gene expression data for Myelofibrosis.

Pathways for genes affiliated with Myelofibrosis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Myelofibrosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6BMP6, JAK2, STAT5A, FLT3, LIF, PF4
2
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10.6BMP6, JAK2, STAT5A, FLT3, LIF, PF4
3
Hide members
10.6BMP6, JAK2, LIF, PF4, FGF2, IL3
4
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10.6KIT, TNFRSF11B, JAK2, STAT5A, FLT3, MPL
5
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10.6BMP6, JAK2, STAT5A, FLT3, FGF2, IL3
610.6IFNA2, JAK2, STAT5A, MPL, LIF, EPO
710.5IFNA2, JAK2, EPO, FGF2, IL3, KIT
8
Hide members
10.5IFNA2, JAK2, GATA1, MPL, CD177, PF4
9
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10.5BMP6, LIF, FGF2, IL3, KIT, THPO
10
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10.5BMP6, FLT3, FGF2, IL3, KIT, THPO
11
Hide members
10.5BMP6, FLT3, FGF2, IL3, KIT, THPO
1210.5FLT3, EPO, IL3, IL11, KIT, THPO
13
Hide members
10.5JAK2, STAT5A, MPL, THPO
14
Development Thrombopoetin signaling via JAK-STAT pathway
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10.5JAK2, STAT5A, MPL, THPO
1510.5KIT, FGF2, FLT3, JAK2
16
Hide members
10.5JAK2, STAT5A, EPO, KIT
17
Hide members
10.5FLT3, FGF2, KIT, THPO
18
Hide members
10.5KIT, FGF2, STAT5A, JAK2
1910.5JAK2, GATA1, STAT5A, IL3
20
Hide members
10.5THPO, IL3, JAK2
21
Hide members
10.5BMP6, FGF2, IL3, THPO
22
Hide members
10.5IL3, FLT3, STAT5A, JAK2
23
Hide members
10.5IL3, STAT5A, JAK2, IFNA2
24
Development EPO-induced Jak-STAT pathway
Hide members
10.5EPO, STAT5A, JAK2
25
Hide members
10.5MPL, THPO
26
Immune response IL-2 activation and signaling pathway
Hide members
10.5IL3, STAT5A, JAK2
2710.5STAT5A, FGF2, IL3, IL11
28
Hide members
10.5BMP6, THPO

Compounds for genes affiliated with Myelofibrosis

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Myelofibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1MPL, STAT5A, JAK2, BMP6, TNFRSF11B, IFNA2
2vegf4411.0THPO, IL11, FGF2, KIT, PF4, EPO
3gp 1304411.0TNFRSF11B, BMP6, JAK2, STAT5A, FLT3, MPL
4thymidine44 2412.0JAK2, BMP6, IFNA2, STAT5A, PF4, THPO
5retinoic acid44 2412.0JAK2, THPO, HMGA2, IL11, IL3, BMP6
6phosphatidylinositol4411.0FLT3, THPO, KIT, IL11, IL3, FGF2
7cytarabine44 49 1113.0EPO, IL3, IL11, KIT, THPO, LIF
8agar4411.0LIF, MPL, IFNA2, THPO, FGF2, PF4
9methylcellulose4411.0IL11, THPO, FLT3, LIF, EPO, FGF2
10anagrelide44 1112.0IFNA2, JAK2, MPL, EPO, PF4, THPO
11hydroxyurea44 49 1113.0PF4, THPO, GATA1, EPO, IL3, IFNA2
12cyclosporin a44 28 5913.0JAK2, IL3, FGF2, IL11, FKBP5, LIF
13cysteine4411.0IL3, STAT5A, JAK2, MPL, AHSG, PF4
14imatinib44 49 1113.0FLT3, THPO, STAT5A, IL3, JAK2, KIT
15steroid4411.0FKBP5, GATA1, IFNA2, THPO, LIF, STAT5A
16rapamycin4411.0STAT5A, FLT3, JAK2, BMP6, EPO, THPO
17filgrastim44 1111.9THPO, IL11, IL3, EPO, IFNA2, LIF
18tgf beta14410.9IL11, THPO, PF4, TNFRSF11B, FLT3, BMP6
19estrogen4410.9AHSG, THPO, GATA1
20gm-csf44 2811.9THPO, STAT5A, IL11, LIF
21doxorubicin44 49 1112.9HMGA2, KIT, IL11, IL3, GATA1, FLT3
22pixy3214410.9THPO, EPO, IL3, IL11, FLT3
235fluorouracil4410.9THPO, MPL, KIT, IL11, IL3, PF4
24cycloheximide4410.9GATA1, FKBP5
25aspartate4410.9IL11, FLT3, GATA1, STAT5A, BMP6, JAK2
2612-o-tetradecanoylphorbol 13-acetate4410.9GATA1, IFNA2, IL11, IL3, PF4, LIF
27hydrocortisone44 2 59 1113.9FGF2, TNFRSF11B, LIF, STAT5A, EPO
28pd 98,0594410.9STAT5A, JAK2, FGF2, IL3, KIT, BMP6
29ly2940024410.9STAT5A, FGF2, BMP6, IL3, THPO, TNFRSF11B
30herbimycin a44 5911.9IL3, FGF2, BMP6, JAK2, STAT5A, IL11
31alanine4410.9STAT5A, MPL, PF4, JAK2, FGF2, IL3
32dexamethasone44 49 28 1113.9IL3, TNFRSF11B, FKBP5, FGF2, BMP6, LIF
33carboplatin44 49 1112.9THPO, EPO, IL11, IFNA2, LIF, IL3
34actinomycin d4410.9KIT, GATA1, JAK2, LIF, FGF2, IL3
35indomethacin44 59 28 1113.8PF4
36calcitriol44 59 11 2413.8IL11, BMP6, LIF, EPO, TNFRSF11B, IL3
37polyethylene glycol4410.8IFNA2, BMP6, PF4, IL11, THPO, MPL
38progesterone44 59 28 11 2414.8KIT, IL11, FKBP5, LIF, STAT5A, GATA1
39il 114410.8LIF, IL11, EPO, IL3
40azathioprine44 49 2 1113.8TNFRSF11B, IL11, EPO, GATA1, IFNA2, LIF
41rantes4410.7THPO, IL3, PF4, LIF, BMP6, IL11
42lactate4410.7BMP6, FLT3, PF4, LIF, EPO, IL3
43etoposide44 49 59 1113.7IL3, THPO, IFNA2, STAT5A, FLT3, PF4
44oligonucleotide4410.7GATA1, THPO, IL11, KIT, LIF, FLT3
45ascorbic acid44 2411.6LIF, EPO, FGF2, IL3, JAK2, TNFRSF11B
46glucose4410.6AHSG, IFNA2, PF4, IL11, LIF
47sb 20358044 5911.5TNFRSF11B, BMP6, THPO, LIF, STAT5A, JAK2
48butyrate4410.5JAK2, THPO, IL11, GATA1
49ag-12964410.4FLT3, KIT, IL3, STAT5A
50amifostine44 1111.2THPO, IL11, IL3, EPO

GO Terms for genes affiliated with Myelofibrosis

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16Gene Ontology
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Cellular components related to Myelofibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5TNFRSF11B, EPO, AHSG, PF4, FGF2, IL3
2extracellular spaceGO:00561510.3THPO, IFNA2, TNFRSF11B, BMP6, LIF, EPO

Biological processes related to Myelofibrosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828410.9KIT, JAK2, FLT3, LIF, EPO, FGF2
2blood coagulationGO:00759610.9IFNA2, JAK2, GATA1, MPL, CD177, PF4
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9KIT, IL3, EPO, JAK2
4positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9JAK2, GATA1, LIF, IL3, IL11
5positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.9KIT, LIF, JAK2, IFNA2
6peptidyl-tyrosine phosphorylationGO:01810810.9KIT, FLT3, STAT5A, JAK2
7positive regulation of transcription from RNA polymerase II promoterGO:04594410.9BMP6, GATA1, STAT5A, LIF, FGF2, IL11
8cytokine-mediated signaling pathwayGO:01922110.8KIT, PF4, FLT3, JAK2, IFNA2
9positive regulation of MAPK cascadeGO:04341010.8FLT3, LIF, IL11, KIT
10embryonic hemopoiesisGO:03516210.8GATA1, IL3, KIT
11negative regulation of cell proliferationGO:00828510.8JAK2, GATA1, FLT3, LIF, FGF2
12erythrocyte differentiationGO:03021810.8KIT, GATA1, JAK2
13positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.8KIT, FGF2, FLT3
14positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.8KIT, FLT3, JAK2
15tyrosine phosphorylation of Stat3 proteinGO:04250310.8JAK2, LIF
16myeloid progenitor cell differentiationGO:00231810.7FLT3, KIT
17mammary gland epithelium developmentGO:06118010.7STAT5A, JAK2
18platelet activationGO:03016810.7MPL, PF4, IL11, THPO
19positive regulation of phospholipase C activityGO:01086310.7KIT, FGF2
20megakaryocyte differentiationGO:03021910.7IL11, GATA1
21dendritic cell differentiationGO:09702810.6GATA1, FLT3
22positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.6LIF, KIT
23cell-cell signalingGO:00726710.6IFNA2, GATA1, IL3, IL11
24male gonad developmentGO:00858410.5HMGA2, KIT, GATA1
25positive regulation of macrophage differentiationGO:04565110.5LIF, PF4
26cellular response to thyroid hormone stimulusGO:09706710.4KIT, GATA1
27negative regulation of hormone secretionGO:04688810.2LIF, IL11

Molecular functions related to Myelofibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C2H2 zinc finger domain bindingGO:07074210.5HMGA2, GATA1
2cytokine activityGO:00512510.4THPO, IFNA2, TNFRSF11B, BMP6, LIF, FGF2
3growth factor activityGO:00808310.2BMP6, LIF, FGF2, IL3, IL11, THPO

Products for genes affiliated with Myelofibrosis

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  • Antibodies
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Sources for Myelofibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet