MCID: MYL006
MIFTS: 64

Myeloid Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Immune diseases, Blood diseases categories

Summaries for Myeloid Leukemia

About this section


Wikipedia:63 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards based summary: Myeloid Leukemia, also known as myeloid leukemia in remission, is related to leukemia and myelodysplastic syndrome. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Notch Signaling Pathways and TGF-beta Signaling Pathways. The compounds gp 130 and ponatinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid tissue, myeloid and bone, and related mouse phenotypes are tumorigenesis and craniofacial.

Disease Ontology:9 A leukemia that is located in myeloid tissue.

Aliases & Classifications for Myeloid Leukemia

About this section

Myeloid Leukemia, Aliases & Descriptions:

Name: Myeloid Leukemia 9 41 43 60
Myeloid Leukemia in Remission 9 60
Leukemia, Myeloid 41 22
Unspecified Myeloid Leukemia Without Mention of Remission 9
Other Myeloid Leukemia Without Mention of Remission 9
Myeloid Leukemia, Nos, Without Mention of Remission 9
Unspecified Myeloid Leukemia in Remission 9
Other Myeloid Leukemia, in Remission 60
Other Myeloid Leukemia in Remission 9
Myeloid Leukemia, No Icd-O Subtype 9
 
Myelogenous Leukemia in Remission 9
Myeloid Granulocytic Leukemia 9
Other Myeloid Leukemia Nos 9
Myeloid Leukemia, Disease 9
Non-Lymphocytic Leukemia 9
Other Myeloid Leukemia 9
Leukemia Myelogenous 9
Myeloid Leukemia Nos 9
Myeloid Leukaemia 9
Myeloid Leukemias 9


Classifications:



External Ids:

Disease Ontology9 DOID:8692
NCIt38 C3172
ICD9CM27 205, 205.9
ICD1025 C92, C92.7

Related Diseases for Myeloid Leukemia

About this section

Diseases in the Myeloid Leukemia family:

Leukemia, Acute Myeloid Leukemia, Chronic Myeloid
Subacute Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
'acute Myeloid Leukemia with T(9;11)(p22;q23)' 'acute Myeloid Leukemia with T(6;9)(p23;q34)'

Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.2RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, NPM1
2myelodysplastic syndrome32.0RUNX1, ABL1, MLF1, PTPN11, FLT3, CBFB
3chronic myelomonocytic leukemia31.6RUNX1, PTPN11, FLT3
4wilms tumor31.5ABL1, FLT3, CREBBP
5acute myeloid leukemia, adult31.5RUNX1, PTPN11, FLT3, NPM1
6leukemia, acute myeloid31.4RUNX1, MLF1, FLT3, CEBPA, NPM1
7refractory anemia31.4FLT3, RUNX1
8leukemia, chronic myeloid31.4RUNX1, ABL1, PTPN11, FLT3, CBFB, CREBBP
9down syndrome31.2RUNX1, FLT3, ERG
10acute leukemia31.1MLF1, PTPN11, FLT3, CBFB, CEBPA, CREBBP
11leukemia, acute promyelocytic31.1RUNX1, RUNX1T1, FLT3, CREBBP, NPM1
12gastrointestinal stromal tumor31.0MYH11, FLT3, ABL1
13acute myelomonocytic leukemia31.0RUNX1, CBFB, CREBBP
14monocytic leukemia31.0LIF, RUNX1
15breast cancer30.8RUNX3, RUNX1, RUNX2, ABL1, PTPN11, FLT3
16colorectal cancer30.7CREBBP, PTPN11, ABL1, RUNX1, RUNX3
17cleidocranial dysplasia30.6RUNX3, RUNX1, RUNX2, CBFB
18precursor t-cell acute lymphoblastic leukemia30.6FLT3, PICALM, ABL1, RUNX1
19retinoblastoma30.4NPM1, CREBBP, CEBPA, ABL1, RUNX2, RUNX1
20leukemia, acute lymphoblastic30.3RUNX1, ABL1, PICALM, PTPN11, FLT3, CBFB
21hematologic cancer30.3RUNX1, RUNX1T1, ABL1, PICALM, PTPN11, FLT3
22cytogenetically normal acute myeloid leukemia11.0
23core binding factor acute myeloid leukemia10.9
24sarcoma10.9
25myeloid sarcoma10.8
26hematopoietic stem cell transplantation10.8
27lymphoblastic leukemia10.7
28endotheliitis10.7
29neutropenia10.7
30mastocytosis10.6
31systemic mastocytosis10.6
32familial acute myeloid leukemia with mutated cebpa10.6
33acute myeloid leukemia with multilineage dysplasia10.6
34myelofibrosis10.6
35subacute myeloid leukemia10.6
36thrombocytosis10.5
37diphtheria10.5
38essential thrombocythemia10.5
39philadelphia-negative chronic myeloid leukemia10.5
40tetraploidy10.5
41aspergillosis10.5
42diabetes insipidus10.5
43mediastinitis10.5
44polycythemia10.5
45aplastic anemia10.5
46multiple myeloma10.5
47chronic lymphocytic leukemia10.5
48thrombocytopenia10.5
49eosinophilia10.5
50myeloma10.5

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Symptoms for Myeloid Leukemia

About this section

Drugs & Therapeutics for Myeloid Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

About this section

Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia22

Anatomical Context for Myeloid Leukemia

About this section

MalaCards organs/tissues related to Myeloid Leukemia:

31
Myeloid, Bone, Bone marrow, T cells, Monocytes, Endothelial, B cells, Neutrophil, Breast, Lung, Testis, Nk cells, Colon, Testes, Skin, Kidney, Lymph node, Brain, Liver, Thyroid, Eye, Spleen, Thymus, Heart, Smooth muscle, Pancreas, Placenta, Prostate, Tonsil, B lymphoblasts, Pituitary

FMA organs/tissues related to Myeloid Leukemia:

14
Myeloid tissue

Animal Models for Myeloid Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Myeloid Leukemia:

35 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8RUNX1, PTPN11, FLT3, CBFB, CEBPA, CREBBP
2MP:00053829.8CREBBP, CBFB, PTPN11, ABL1, RUNX2
3MP:00030129.7RUNX3, RUNX1, RUNX2, PTPN11, CBFB, CEBPA
4MP:00053759.7RUNX3, PTPN11, LIF, CEBPA, CREBBP
5MP:00053919.6RUNX2, ABL1, PTPN11, LIF, CBFB, CEBPA
6MP:00053909.6RUNX3, RUNX1, RUNX2, ABL1, PTPN11, LIF
7MP:00053709.5RUNX1, RUNX2, ABL1, PICALM, PTPN11, LIF
8MP:00028739.5RUNX1, RUNX1T1, ABL1, PTPN11, CEBPA, CREBBP
9MP:00053809.4RUNX1, ABL1, PICALM, PTPN11, LIF, CBFB
10MP:00053889.4ABL1, RUNX2, RUNX1, RUNX3, PTPN11, MYH11
11MP:00053799.4RUNX3, RUNX2, PTPN11, LIF, CEBPA, CREBBP
12MP:00053699.4RUNX3, RUNX2, ABL1, MRVI1, PTPN11, MYH11
13MP:00107719.3RUNX3, RUNX1, RUNX1T1, RUNX2, PTPN11, MYH11
14MP:00036319.2RUNX3, RUNX1, RUNX2, ABL1, PTPN11, LIF
15MP:00053819.2RUNX3, RUNX1T1, RUNX2, ABL1, MRVI1, PTPN11
16MP:00053769.2PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
17MP:00053849.2PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
18MP:00053979.0PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
19MP:00053879.0PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
20MP:00053858.9RUNX1, RUNX1T1, RUNX2, ABL1, MRVI1, PTPN11
21MP:00053788.8NPM1, RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1
22MP:00107688.6PICALM, MRVI1, ABL1, RUNX2, RUNX1T1, RUNX1

Publications for Myeloid Leukemia

About this section

Articles related to Myeloid Leukemia:

(show top 50)    (show all 4848)
idTitleAuthorsYear
1
Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. (24413389)
2014
2
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
3
Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. (24120526)
2014
4
Intraventricular hemorrhage in a patient with chronic myeloid leukemia and anterior communicating artery aneurysm. (23860156)
2013
5
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. (24035334)
2013
6
Treatment-, patient-, and disease-related factors and the emergence of adverse events with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia. (23553655)
2013
7
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. (23912609)
2013
8
Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as T-cell lymphoblastic lymphoma. (23486000)
2013
9
Mobilization of CD34(+)CD38(-) hematopoietic stem cells after priming in acute myeloid leukemia. (24179607)
2013
10
Dasatinib: a guide to its use in chronic myeloid leukemia in the EU. (23549840)
2013
11
Prognostic implication of BAALC gene expression in adult acute myeloid leukemia. (23865362)
2013
12
CAR T cells for acute myeloid leukemia: the LeY of the land. (24201214)
2013
13
Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells. (23878608)
2013
14
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. (22929312)
2012
15
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
16
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-I_B and underlies its chemo-resistance. (23077289)
2012
17
High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group. (22915059)
2012
18
Synergistic effect of 5-azacytidine and NF-I_B inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells. (24139415)
2012
19
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. (22490330)
2012
20
DNMT3A mutations are rare in childhood acute myeloid leukemia. (21685466)
2011
21
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (21951951)
2011
22
Summary of 615 patients of chronic myeloid leukemia in Shanghai from 2001 to 2006. (20199658)
2010
23
A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. (21156465)
2010
24
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. (19637342)
2009
25
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
26
Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (18768433)
2008
27
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. (18616510)
2008
28
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells. (18268283)
2008
29
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. (18401414)
2008
30
Analysis of NPM1 gene mutations in acute myeloid leukemia]. (17877154)
2007
31
Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. (17822317)
2007
32
Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. (17064874)
2007
33
Adenomatoid tumor of the testis in a patient on imatinib therapy for chronic myeloid leukemia. (16923575)
2006
34
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells. (15744347)
2005
35
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (15840695)
2005
36
Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. (15034867)
2004
37
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (12393722)
2003
38
Acute myeloid leukemia associated with necrotizing temporal arteritis. (12672210)
2003
39
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
40
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
41
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. (12145683)
2002
42
Drug therapy of chronic myeloid leukemia]. (11831070)
2002
43
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
44
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. (11568008)
2001
45
Cytokine expression of T cells in chronic myeloid leukemia. (11775253)
2000
46
Induction of gp130 and LIF by differentiation inducers in human myeloid leukemia K562 cells. (10613356)
1999
47
In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor. (9815618)
1997
48
Rearrangements and fusion gene of AML1 and MTG8 in acute myeloid leukemia M2b]. (7553157)
1995
49
Regulation of the expression of vimentin gene during the differentiation of mouse myeloid leukemia cells. (1970825)
1990
50
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984

Variations for Myeloid Leukemia

About this section

Expression for genes affiliated with Myeloid Leukemia

About this section
Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

About this section

Compounds for genes affiliated with Myeloid Leukemia

About this section

Compounds related to Myeloid Leukemia according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1gp 1304310.3PTPN11, FLT3, LIF
2ponatinib49 1211.3FLT3, ABL1
3tgf beta14310.3LIF, FLT3, RUNX2
4agarose4310.3FLT3, LIF, NPM1
5cytarabine43 49 1212.3ABL1, FLT3, LIF
6etoposide43 49 59 1213.3CREBBP, FLT3, PTPN11, RUNX1
7imatinib43 49 1212.2FLT3, PTPN11, ABL1, RUNX1
8doxorubicin43 49 1212.2NPM1, CREBBP, FLT3, RUNX1
9herbimycin a43 5911.2FLT3, PTPN11, ABL1
10fatty acid4310.1RUNX2, LIF, CEBPA, CREBBP, NPM1
11proline4310.1RUNX1, RUNX1T1, ABL1, PTPN11, CREBBP
12thymidine43 2411.1RUNX2, PTPN11, FLT3, LIF
13nitric oxide43 24 1212.0RUNX2, PTPN11, MYH11, LIF, CREBBP
14zinc43 2411.0RUNX1, RUNX1T1, RUNX2, ABL1, CREBBP, NPM1
15cisplatin43 49 59 1212.9CREBBP, LIF, PTPN11, ABL1
16atp43 2810.9ABL1, PTPN11, FLT3, LIF, CREBBP, NPM1
17threonine439.9RUNX1, RUNX1T1, ABL1, PTPN11, FLT3, CREBBP
18phosphatidylinositol439.8RUNX2, ABL1, PTPN11, FLT3, MYH11, LIF
19estrogen439.8RUNX2, ABL1, MYH11, LIF, CEBPA, CREBBP
20glucose439.8CREBBP, CEBPA, LIF, PTPN11, RUNX2
21oligonucleotide439.8RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, PTPN11
22oxygen43 2410.7RUNX2, ABL1, PTPN11, LIF, CREBBP
23vegf439.6RUNX3, RUNX1, RUNX2, ABL1, PTPN11, FLT3
24serine439.6RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, PTPN11
25tyrosine439.6RUNX1, RUNX2, ABL1, PTPN11, FLT3, LIF
26retinoic acid43 2410.5NPM1, RUNX3, RUNX1, RUNX2, ABL1, FLT3
27cysteine439.4ABL1, PTPN11, LIF, CREBBP, NPM1
28calcium43 49 24 1212.3RUNX2, ABL1, MRVI1, PTPN11, LIF, CREBBP

GO Terms for genes affiliated with Myeloid Leukemia

About this section

Cellular components related to Myeloid Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:000079010.1CREBBP, RUNX2, RUNX3
2nucleusGO:00056348.5NPM1, RUNX3, RUNX1, RUNX2, ABL1, PICALM
3cytoplasmGO:00057378.3MLF2, MLF1, ABL1, RUNX2, RUNX3, PTPN11

Biological processes related to Myeloid Leukemia according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system neuron developmentGO:004893510.4RUNX3, RUNX1
2myeloid cell differentiationGO:003009910.3RUNX1, CBFB, CEBPA
3myeloid progenitor cell differentiationGO:000231810.3FLT3, MLF1, RUNX1
4hemopoiesisGO:003009710.3FLT3, PICALM, RUNX1
5definitive hemopoiesisGO:006021610.3CBFB, RUNX1
6hair follicle morphogenesisGO:003106910.3RUNX1, RUNX3
7cell maturationGO:004846910.2CEBPA, CBFB, RUNX2, RUNX3
8regulation of endocytosisGO:003010010.1PICALM, ABL1
9axon guidanceGO:000741110.0MYH11, PTPN11, ABL1, RUNX3
10transcription from RNA polymerase II promoterGO:000636610.0RUNX3, LIF, CBFB, CEBPA, ERG
11negative regulation of cell proliferationGO:00082859.9FLT3, LIF, CEBPA, NPM1
12positive regulation of transcription, DNA-templatedGO:00458939.7RUNX1, RUNX2, PICALM, CREBBP

Molecular functions related to Myeloid Leukemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1repressing transcription factor bindingGO:007049110.3RUNX2, RUNX1
2protein homodimerization activityGO:00428039.9RUNX1, RUNX1T1, FLT3, CEBPA, NPM1
3protein domain specific bindingGO:00199049.7PTPN11, MLF1, RUNX2
4sequence-specific DNA binding transcription factor activityGO:00037009.7RUNX3, RUNX1, RUNX1T1, RUNX2, CBFB, CEBPA
5ATP bindingGO:00055249.6RUNX3, RUNX1, RUNX2, ABL1, FLT3, MYH11
6DNA bindingGO:00036779.5RUNX1, RUNX1T1, ABL1, MLF1, CBFB, CEBPA
7protein bindingGO:00055158.2NPM1, RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1

Products for genes affiliated with Myeloid Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Myeloid Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet