MCID: MYL006
MIFTS: 72

Myeloid Leukemia malady

Cancer diseases, Immune diseases categories

Summaries for Myeloid Leukemia

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards: Myeloid Leukemia, also known as other myeloid leukemia, is related to leukemia and acute leukemia. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The compounds retinoic acid and serine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are mortality/aging and growth/size.

Aliases & Classifications for Myeloid Leukemia

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

myeloid leukemia 8 42 44 60
other myeloid leukemia 8 60
leukemia, myeloid 42 22
unspecified myeloid leukemia without mention of remission 8
myeloid leukemia, nos, without mention of remission 8
other myeloid leukemia without mention of remission 8
unspecified myeloid leukemia in remission 8
other myeloid leukemia in remission 8
myeloid leukemia, no icd-o subtype 8
myelogenous leukemia in remission 8
myeloid granulocytic leukemia 8
myeloid leukemia in remission 8
other myeloid leukemia nos 8
myeloid leukemia, disease 8
non-lymphocytic leukemia 8
leukemia myelogenous 8
myeloid leukemia nos 8
myeloid leukaemia 8
myeloid leukemias 8


External Ids:

Disease Ontology8 DOID:8692
ICD9CM27 205, 205.9
NCIt39 C3172
ICD1025 C92, C92.7

Related Diseases for Myeloid Leukemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
myeloid leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 394)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.7ERG, PICALM, PIK3CG, NPM1, RUNX1T1, RUNX1
2acute leukemia32.6NPM1, RUNX1T1, RUNX1, PTPN11, KMT2A, ABL1
3acute myeloid leukemia32.5RUNX1, NPM1, PICALM, FLT3, MLF1
4chronic myeloid leukemia32.3RUNX1, PIK3CG, CREBBP, FLT3, CBFB, ABL1
5myeloid sarcoma31.2KMT2A, FLT3
6sarcoma31.2RUNX1, PIK3CG
7monocytic leukemia31.1KMT2A, LIF, RUNX1
8acute monocytic leukemia31.0KMT2A, CREBBP
9acute lymphocytic leukemia30.9RUNX1, PICALM, CREBBP, FLT3, CBFB, ABL1
10breast cancer30.8RUNX3, RUNX2, RUNX1, NPM1, PIK3CG, CREBBP
11down syndrome30.8RUNX1, FLT3, ERG
12myelofibrosis30.7LIF
13thrombocytosis30.7LIF, FLT3
14acute myeloid leukemia, adult30.7RUNX1, NPM1, FLT3, KMT2A, PTPN11
15polycythemia vera30.6FLT3
16myeloma30.6PIK3CG, LIF
17megakaryocytic leukemia30.4RUNX1, KMT2A
18acute promyelocytic leukemia30.4RUNX1, RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3
19juvenile myelomonocytic leukemia30.4RUNX1, FLT3, PTPN11
20gastrointestinal stromal tumor30.4FLT3, MYH11, ABL1
21colorectal cancer30.3CREBBP, RUNX3
22melanoma30.3PIK3CG, FLT3, ABL1, PTPN11
23adenocarcinoma30.2RUNX3, PIK3CG, CREBBP, LIF, MYH11, KMT2A
24acute myelomonocytic leukemia30.2RUNX1, CREBBP, CBFB, KMT2A
25thyroid cancer30.0FLT3, ABL1
26colon cancer29.9RUNX3, RUNX1, PIK3CG, CREBBP, ABL1, PTPN11
27retinoblastoma29.9ABL1, CREBBP, PIK3CG, NPM1, RUNX1, RUNX2
28cleidocranial dysplasia29.9RUNX3, RUNX2, RUNX1, CBFB
29childhood leukemia10.9
30acute t cell leukemia10.8
31t-cell leukemia10.8
32lymphoid leukemia10.8
33lymphoblastic leukemia10.7
34chronic lymphocytic leukemia10.6
35neutropenia10.6
36familial acute myeloid leukemia with mutated cebpa10.6
37systemic mastocytosis10.5
38subacute myeloid leukemia10.5
39graft versus host disease10.5
40natural killer cell leukemia10.5
41mast-cell leukemia10.5
42diphtheria10.5
43cytogenetically normal acute myeloid leukemia10.5
44aspergillosis10.5
45polycythemia10.5
46core binding factor acute myeloid leukemia10.5
47diabetes insipidus10.4
48central nervous system leukemia10.4
49mediastinitis10.4
50invasive aspergillosis10.4

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Clinical Features for Myeloid Leukemia

About this section

Drugs & Therapeutics for Myeloid Leukemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Search CenterWatch for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

About this section
Sources:
22GTR
See all sources

Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia22

Anatomical Context for Myeloid Leukemia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, T cells, Monocytes, Endothelial, B cells, Breast, Nk cells, Lung, Testis, Testes, Colon, Skin, Kidney, Lymph node, Brain, Liver, Thyroid, Placenta, Tonsil, Pancreas, Small intestine, Smooth muscle, Pituitary, Eye, Spleen, Heart, B lymphoblasts

Animal Models for Myeloid Leukemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Myeloid Leukemia:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076814.1PIK3CG, NPM1, MRVI1, RUNX1T1, RUNX1, RUNX2
2MP:000537813.9ERG, RUNX3, RUNX2, RUNX1, RUNX1T1, NPM1
3MP:000538513.5PIK3CG, NPM1, MRVI1, RUNX1T1, RUNX1, RUNX2
4MP:000539713.5PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
5MP:000538713.5PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
6MP:000538413.4PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
7MP:000537613.4CREBBP, PICALM, PIK3CG, RUNX1, RUNX2, RUNX3
8MP:000538112.7RUNX3, RUNX2, RUNX1T1, MRVI1, CREBBP, LIF
9MP:000537012.4RUNX2, RUNX1, NPM1, PICALM, LIF, CBFB
10MP:000536912.3RUNX3, RUNX2, MRVI1, PIK3CG, CREBBP, LIF
11MP:001077112.3RUNX3, RUNX1, RUNX1T1, NPM1, PIK3CG, LIF
12MP:000363112.3RUNX1, NPM1, CREBBP, LIF, CBFB, ABL1
13MP:000538812.0RUNX3, RUNX2, CREBBP, LIF, CBFB, ABL1
14MP:000539011.8RUNX3, PIK3CG, CREBBP, LIF, CBFB, KMT2A
15MP:000200611.8RUNX1, NPM1, CREBBP, FLT3, CBFB, KMT2A
16MP:000301211.6PTPN11, KMT2A, CBFB, RUNX1, RUNX2, RUNX3
17MP:000538211.3RUNX2, CREBBP, CBFB, ABL1, KMT2A, PTPN11
18MP:000539111.0LIF, NPM1, RUNX2
19MP:000538010.8KMT2A

Publications for Myeloid Leukemia

About this section
Sources:
50PubMed
See all sources

Articles related to Myeloid Leukemia:

(show top 50)    (show all 4899)
idTitleAuthorsYear
1
Grover Disease (Transient Acantholytic Dermatosis) in Acute Myeloid Leukemia on FDG PET/CT. (24152615)
2014
2
CAR T cells for acute myeloid leukemia: the LeY of the land. (24201214)
2013
3
Health conditions and quality of life in survivors of childhood acute myeloid leukemia comparing post remission chemotherapy to BMT: A report from the children's oncology group. (24285698)
2013
4
Chemomodulation of sequential high-dose cytarabine by fludarabine in relapsed or refractory acute myeloid leukemia: a randomized trial of the AMLCG. (24150216)
2013
5
(6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression. (24378438)
2013
6
"To switch or not to switch: that is the question"-more than 10% of ratio @ 3 months: how to treat chronic myeloid leukemia patients with this response? (23806235)
2013
7
Chronic myeloid leukemia: overview of new agents and comparative analysis. (23572291)
2013
8
Combinatorial molecular marker assays of WT1, survivin, and TERT at initial diagnosis of adult acute myeloid leukemia. (23826993)
2013
9
Preclinical and phase i results of decitabine in combination with midostaurin (PKC412) for newly diagnosed elderly or relapsed/refractory adult patients with acute myeloid leukemia. (23798029)
2013
10
Measuring the symptom burden associated with the treatment of chronic myeloid leukemia. (23777764)
2013
11
BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy. (23812934)
2013
12
Stem cell maintenance and disease progression in chronic myeloid leukemia. (23550022)
2013
13
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. (22124213)
2012
14
The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL (tumor necrosis factor I+-related apoptosis-inducing ligand) by regulating the antiapoptotic protein Bcl-xL. (22898820)
2012
15
Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis in chronic myeloid leukemia (CML) cells. (22330069)
2012
16
miR-29a and miR-142-3p downregulation and diagnostic implication in human acute myeloid leukemia. (21678057)
2012
17
Expression of four major WT1 splicing variants in acute and chronic myeloid leukemia patients analyzed by newly developed four real-time RT PCRs. (22555024)
2012
18
Bone infarcts in a case of chronic myeloid leukemia: chronic phase. (23997459)
2012
19
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia. (21993668)
2012
20
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (21951951)
2011
21
High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. (20732714)
2011
22
Differential prognosis impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. (21454467)
2011
23
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. (20421455)
2010
24
Implementation of direct sequencing as a method of ABL gene mutations analysis in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitor]. (21591355)
2010
25
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. (19797526)
2009
26
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. (19075190)
2009
27
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
28
Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia. (18524988)
2008
29
HOX gene regulation in acute myeloid leukemia: CDX marks the spot? (17881901)
2007
30
NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia. (17213804)
2007
31
Identification of novel nuclear localization signals of Drosophila myeloid leukemia factor. (18159124)
2007
32
Expression of MAC-1 (CD11b) in acute myeloid leukemia (AML) is associated with an unfavorable prognosis. (16550517)
2006
33
Clinical implications of angiogenic factors in patients with acute or chronic leukemia: hepatocyte growth factor levels have prognostic impact, especially in patients with acute myeloid leukemia. (16019534)
2005
34
Gender aspects in chronic myeloid leukemia: long-term results from randomized studies. (15830009)
2005
35
High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. (15173080)
2004
36
Core binding factor acute myeloid leukemia. Cancer and Leukemia Group B (CALGB) Study 8461. (15124687)
2004
37
Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia. (15014900)
2004
38
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. (14726504)
2004
39
Childhood and adolescent lymphoid and myeloid leukemia. (15561680)
2004
40
Efficacy and toxicity of low-dose melphalan in myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. (12937849)
2003
41
Acute disseminated encephalomyelitis (ADEM) after allogeneic bone marrow transplantation for acute myeloid leukemia. (12574963)
2003
42
Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22. (11379876)
2001
43
Mylotarg approved for patients with CD33+ acute myeloid leukemia. (11899326)
2000
44
Safe mobilization of normal progenitors in advanced chronic myeloid leukemia with intensive chemotherapy and granulocyte-colony stimulating factor. (10071133)
1999
45
Inhibition by ascorbic acid of apoptosis induced by oxidative stress in HL-60 myeloid leukemia cells. (10075088)
1999
46
The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias. (9234595)
1997
47
MTS1 expression and prognosis in acute myeloid leukemia. (9402846)
1997
48
T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination. (9379684)
1997
49
Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody. (3304620)
1987
50
The therapeutic application of radioactive phosphorus with special reference to the treatment of primary polycythemia and chronic myeloid leukemia. (15407496)
1949

Genetic Variations for Myeloid Leukemia

About this section

Expression for genes affiliated with Myeloid Leukemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myeloid Leukemia

Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

About this section
Sources:
29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
See all sources

Compounds for genes affiliated with Myeloid Leukemia

About this section
Sources:
44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2414.0KMT2A, RUNX3, RUNX2, RUNX1, NPM1, PIK3CG
2serine4413.0RUNX3, RUNX2, RUNX1, RUNX1T1, PIK3CG, CREBBP
3vegf4412.8PIK3CG, RUNX1, RUNX2, RUNX3, CREBBP, FLT3
4tyrosine4412.7RUNX2, RUNX1, NPM1, PIK3CG, CREBBP, FLT3
5oligonucleotide4412.6RUNX3, RUNX2, RUNX1, RUNX1T1, FLT3, LIF
6threonine4412.6RUNX1, RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3
7phosphatidylinositol4412.4RUNX2, PIK3CG, CREBBP, FLT3, LIF, MYH11
8zinc44 2413.1RUNX2, RUNX1, RUNX1T1, NPM1, CREBBP, ABL1
9atp44 2813.1NPM1, CREBBP, FLT3, LIF, ABL1, KMT2A
10etoposide44 49 59 1115.0RUNX1, PIK3CG, CREBBP, FLT3, KMT2A, PTPN11
11doxorubicin44 49 1114.0RUNX1, NPM1, PIK3CG, CREBBP, FLT3, KMT2A
12proline4411.9RUNX1, RUNX1T1, CREBBP, ABL1, KMT2A, PTPN11
13imatinib44 49 1113.8RUNX1, PIK3CG, FLT3, ABL1, PTPN11
14herbimycin a44 5912.5PIK3CG, FLT3, ABL1, PTPN11
15phosphotyrosine4411.5PTPN11, ABL1, FLT3, PIK3CG
16sb 20358044 5912.4RUNX2, PIK3CG, LIF, PTPN11
17roscovitine4411.3CREBBP, PIK3CG, RUNX2
18rapamycin4411.3NPM1, PIK3CG, FLT3, PTPN11
19phenylephrine44 28 11 2414.3PIK3CG, CREBBP, LIF
20actinomycin d4411.2KMT2A, LIF, PIK3CG, NPM1
21paclitaxel44 49 1113.2NPM1, PIK3CG, LIF
22gp 1304411.2PTPN11, LIF, FLT3
23pd 98,0594411.1RUNX2, PIK3CG, CREBBP, LIF
24af 104411.1KMT2A, PICALM
25cytarabine44 49 1113.1ABL1, LIF, FLT3
26estrogen4411.0KMT2A
27ag-12964411.0FLT3, PIK3CG
28ly2940024410.9RUNX2, PIK3CG, MYH11, PTPN11

GO Terms for genes affiliated with Myeloid Leukemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1RUNX1, RUNX3, RUNX2, NPM1, PICALM, CREBBP
2cytoplasmGO:00573712.5MLF2, MLF1, CREBBP, RUNX2, NPM1, PIK3CG
3nuclear chromatinGO:00079011.1RUNX3, RUNX2, CREBBP

Biological processes related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589311.6KMT2A, CREBBP, PICALM, RUNX1, RUNX2
2myeloid progenitor cell differentiationGO:00231811.3MLF1, FLT3, RUNX1
3cell maturationGO:04846911.3CBFB, RUNX2, RUNX3
4hemopoiesisGO:03009711.3RUNX1, PICALM, FLT3
5axon guidanceGO:00741111.2RUNX3, MYH11, ABL1, PTPN11
6peripheral nervous system neuron developmentGO:04893511.0RUNX3, RUNX1
7regulation of cell adhesion mediated by integrinGO:03362811.0PTPN11, PIK3CG
8protein complex assemblyGO:00646111.0KMT2A, CREBBP, PICALM
9definitive hemopoiesisGO:06021610.9CBFB, RUNX1
10myeloid cell differentiationGO:03009910.9CBFB, RUNX1
11regulation of endocytosisGO:03010010.6ABL1, PICALM

Molecular functions related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.7ERG, RUNX3, RUNX2, RUNX1, RUNX1T1, MRVI1
2sequence-specific DNA binding transcription factor activityGO:00370011.9RUNX3, RUNX2, RUNX1, RUNX1T1, CREBBP, CBFB
3ATP bindingGO:00552411.5RUNX3, RUNX2, RUNX1, PIK3CG, FLT3, MYH11
4protein homodimerization activityGO:04280311.4KMT2A, FLT3, NPM1, RUNX1T1, RUNX1

Products for genes affiliated with Myeloid Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myeloid Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet