MCID: MYL006
MIFTS: 72

Myeloid Leukemia malady

Cancer diseases, Immune diseases categories

Summaries for Myeloid Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards: Myeloid Leukemia, also known as other myeloid leukemia, is related to leukemia and acute leukemia. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The compounds retinoic acid and serine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are mortality/aging and growth/size.

Aliases & Classifications for Myeloid Leukemia

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

myeloid leukemia 8 42 44 60
other myeloid leukemia 8 60
leukemia, myeloid 42 22
unspecified myeloid leukemia without mention of remission 8
myeloid leukemia, nos, without mention of remission 8
other myeloid leukemia without mention of remission 8
unspecified myeloid leukemia in remission 8
other myeloid leukemia in remission 8
myeloid leukemia, no icd-o subtype 8
myelogenous leukemia in remission 8
myeloid granulocytic leukemia 8
myeloid leukemia in remission 8
other myeloid leukemia nos 8
myeloid leukemia, disease 8
non-lymphocytic leukemia 8
leukemia myelogenous 8
myeloid leukemia nos 8
myeloid leukaemia 8
myeloid leukemias 8


External Ids:

Disease Ontology8 DOID:8692
ICD9CM27 205, 205.9
NCIt39 C3172
ICD1025 C92, C92.7

Related Diseases for Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
myeloid leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 394)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.7ERG, PICALM, PIK3CG, NPM1, RUNX1T1, RUNX1
2acute leukemia32.6NPM1, RUNX1T1, RUNX1, PTPN11, KMT2A, ABL1
3acute myeloid leukemia32.5RUNX1, NPM1, PICALM, FLT3, MLF1
4chronic myeloid leukemia32.3RUNX1, PIK3CG, CREBBP, FLT3, CBFB, ABL1
5myeloid sarcoma31.2KMT2A, FLT3
6sarcoma31.2RUNX1, PIK3CG
7monocytic leukemia31.1KMT2A, LIF, RUNX1
8acute monocytic leukemia31.0KMT2A, CREBBP
9acute lymphocytic leukemia30.9RUNX1, PICALM, CREBBP, FLT3, CBFB, ABL1
10breast cancer30.8RUNX3, RUNX2, RUNX1, NPM1, PIK3CG, CREBBP
11down syndrome30.8RUNX1, FLT3, ERG
12myelofibrosis30.7LIF
13thrombocytosis30.7LIF, FLT3
14acute myeloid leukemia, adult30.7RUNX1, NPM1, FLT3, KMT2A, PTPN11
15polycythemia vera30.6FLT3
16myeloma30.6PIK3CG, LIF
17megakaryocytic leukemia30.4RUNX1, KMT2A
18acute promyelocytic leukemia30.4RUNX1, RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3
19juvenile myelomonocytic leukemia30.4RUNX1, FLT3, PTPN11
20gastrointestinal stromal tumor30.4FLT3, MYH11, ABL1
21colorectal cancer30.3CREBBP, RUNX3
22melanoma30.3PIK3CG, FLT3, ABL1, PTPN11
23adenocarcinoma30.2RUNX3, PIK3CG, CREBBP, LIF, MYH11, KMT2A
24acute myelomonocytic leukemia30.2RUNX1, CREBBP, CBFB, KMT2A
25thyroid cancer30.0FLT3, ABL1
26colon cancer29.9RUNX3, RUNX1, PIK3CG, CREBBP, ABL1, PTPN11
27retinoblastoma29.9ABL1, CREBBP, PIK3CG, NPM1, RUNX1, RUNX2
28cleidocranial dysplasia29.9RUNX3, RUNX2, RUNX1, CBFB
29childhood leukemia10.9
30acute t cell leukemia10.8
31t-cell leukemia10.8
32lymphoid leukemia10.8
33lymphoblastic leukemia10.7
34chronic lymphocytic leukemia10.6
35neutropenia10.6
36familial acute myeloid leukemia with mutated cebpa10.6
37systemic mastocytosis10.5
38subacute myeloid leukemia10.5
39graft versus host disease10.5
40natural killer cell leukemia10.5
41mast-cell leukemia10.5
42diphtheria10.5
43cytogenetically normal acute myeloid leukemia10.5
44aspergillosis10.5
45polycythemia10.5
46core binding factor acute myeloid leukemia10.5
47diabetes insipidus10.4
48central nervous system leukemia10.4
49mediastinitis10.4
50invasive aspergillosis10.4

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Clinical Features for Myeloid Leukemia

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Drugs & Therapeutics for Myeloid Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Search CenterWatch for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

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22GTR
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Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia22

Anatomical Context for Myeloid Leukemia

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32MalaCards
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MalaCards organs/tissues related to Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, T cells, Monocytes, Endothelial, B cells, Breast, Nk cells, Lung, Testis, Testes, Colon, Skin, Kidney, Lymph node, Brain, Liver, Thyroid, Placenta, Tonsil, Pancreas, Small intestine, Smooth muscle, Pituitary, Eye, Spleen, Heart, B lymphoblasts

Animal Models for Myeloid Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloid Leukemia:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076814.1PIK3CG, NPM1, MRVI1, RUNX1T1, RUNX1, RUNX2
2MP:000537813.9ERG, RUNX3, RUNX2, RUNX1, RUNX1T1, NPM1
3MP:000538513.5PIK3CG, NPM1, MRVI1, RUNX1T1, RUNX1, RUNX2
4MP:000539713.5PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
5MP:000538713.5PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
6MP:000538413.4PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
7MP:000537613.4CREBBP, PICALM, PIK3CG, RUNX1, RUNX2, RUNX3
8MP:000538112.7RUNX3, RUNX2, RUNX1T1, MRVI1, CREBBP, LIF
9MP:000537012.4RUNX2, RUNX1, NPM1, PICALM, LIF, CBFB
10MP:000536912.3RUNX3, RUNX2, MRVI1, PIK3CG, CREBBP, LIF
11MP:001077112.3RUNX3, RUNX1, RUNX1T1, NPM1, PIK3CG, LIF
12MP:000363112.3RUNX1, NPM1, CREBBP, LIF, CBFB, ABL1
13MP:000538812.0RUNX3, RUNX2, CREBBP, LIF, CBFB, ABL1
14MP:000539011.8RUNX3, PIK3CG, CREBBP, LIF, CBFB, KMT2A
15MP:000200611.8RUNX1, NPM1, CREBBP, FLT3, CBFB, KMT2A
16MP:000301211.6PTPN11, KMT2A, CBFB, RUNX1, RUNX2, RUNX3
17MP:000538211.3RUNX2, CREBBP, CBFB, ABL1, KMT2A, PTPN11
18MP:000539111.0LIF, NPM1, RUNX2
19MP:000538010.8KMT2A

Publications for Myeloid Leukemia

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50PubMed
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Articles related to Myeloid Leukemia:

(show top 50)    (show all 4899)
idTitleAuthorsYear
1
Treating chronic myeloid leukemia in the era of tyrosine kinase inhibitors. (23774684)
2013
2
Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients a8o60 years with newly diagnosed acute myeloid leukemia. (23877926)
2013
3
Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia. (23748345)
2013
4
Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis. (23459450)
2013
5
Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. (23704090)
2013
6
Somatic 15q Break After Long-Term Stable Disease in Acute Myeloid Leukemia. (24361186)
2013
7
MicroRNA profiling in chemoresistant and chemosensitive acute myeloid leukemia. (23689423)
2013
8
Mutated regions of nucleophosmin 1 elicit both CD4(+) and CD8(+) T-cell responses in patients with acute myeloid leukemia. (22592607)
2012
9
A somatic EZH2 mutation in childhood acute myeloid leukemia. (22266912)
2012
10
Megakaryoblastic leukemia presenting as pancytopenia and extensive myelofibrosis in a child diagnosed by myeloid markers and CD 31. (22754213)
2012
11
No asthma, no parasites is a rare type of leukemia: chronic myeloid neoplasm with eosinophilia and abnormality of platelet-derived growth factor receptor alpha. (23156891)
2012
12
Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22). (22403058)
2012
13
Dasatinib may overcome the negative prognostic impact of KIR2DS1 in newly diagnosed patients with chronic myeloid leukemia. (22822001)
2012
14
FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients. (22902056)
2012
15
Familial aggregation of acute myeloid leukemia and myelodysplastic syndromes. (22162584)
2012
16
MicroRNA-451 in chronic myeloid leukemia: miR-451-BCR-ABL regulatory loop? (21511335)
2011
17
The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia. (20570349)
2011
18
Relapse of Acute Myeloid Leukemia with t(16;21)(p11;q22) Mimicking Autoimmune Pancreatitis after Second Allogeneic Bone Marrow Transplantation. (22084695)
2011
19
Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias. (19901261)
2010
20
Expression of NF-kappaB mRNA in acute myeloid leukemia]. (20416168)
2010
21
Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival. (19626541)
2009
22
New mutations detected by denaturing high performance liquid chromatography during screening of exon 6 bcr-abl mutations in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. (19557636)
2009
23
Expression of the CDH13 gene and BCR/ABL fusion gene in chronic myeloid leukemia patients and their relationship]. (19199263)
2009
24
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. (18083845)
2008
25
Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. (18418409)
2008
26
Chronic meningitis by histoplasmosis: report of a child with acute myeloid leukemia. (19287853)
2008
27
Accumulating evidence for a role of p53 in multiple drug resistant acute myeloid leukemia. (18297513)
2008
28
TRIB1 overexpression in acute myeloid leukemia. (17574965)
2007
29
Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors. (16489085)
2006
30
Enhanced sensitivity to inhibition of SHP2, STAT5, and Gab2 expression in chronic myeloid leukemia (CML). (16278304)
2006
31
Long duration priapism in blast crisis of chronic myeloid leukemia. (15656063)
2004
32
Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation. (15122318)
2004
33
Mutation of CEBPA in familial acute myeloid leukemia. (15575056)
2004
34
High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia. (15159312)
2004
35
Bilateral orbital myeloid sarcoma as initial sign of acute myeloid leukemia: case report and review of the literature. (12523908)
2003
36
MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. (12676584)
2003
37
A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. (12933575)
2003
38
Unlike AML1, CBFbeta gene is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes. (11986246)
2002
39
In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo. (12453880)
2002
40
Microdissection and FISH investigations in acute myeloid leukemia: a step forward to full identification of complex karyotypic changes. (10731587)
2000
41
L-selectin expression is low on CD34+ cells from patients with chronic myeloid leukemia and interferon-a up-regulates this expression. (10681720)
2000
42
Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia. (11027640)
2000
43
Study on the sensitization of acute myeloid leukemia cell to daunorubicin by recombinant human interleukin-3]. (11498841)
1999
44
Coincidence of Gaucher's disease due to a private mutation and Ph' positive chronic myeloid leukemia. (9723584)
1998
45
Phenotypic conversion from t(8;21) acute myeloid leukemia to MLL gene rearrangement-positive acute lymphoblastic leukemia. (9844825)
1998
46
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. (9326217)
1997
47
Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. (8288641)
1994
48
Regulation of CD9 expression during 12-O-tetradecanoyl-phorbol-13-acetate- induced differentiation of human myeloid leukemia (HL-60) cells. (7848923)
1994
49
Expression of myeloid differentiation antigens in acute nonlymphocytic leukemia: increased concentration of CD33 antigen predicts poor outcome--a report from the Childrens Cancer Study Group. (1574028)
1992
50
Recurrent bilateral parotitis in acute myeloid leukemia. (1950368)
1991

Genetic Variations for Myeloid Leukemia

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Expression for genes affiliated with Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Leukemia

Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Myeloid Leukemia

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44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2414.0KMT2A, RUNX3, RUNX2, RUNX1, NPM1, PIK3CG
2serine4413.0RUNX3, RUNX2, RUNX1, RUNX1T1, PIK3CG, CREBBP
3vegf4412.8PIK3CG, RUNX1, RUNX2, RUNX3, CREBBP, FLT3
4tyrosine4412.7RUNX2, RUNX1, NPM1, PIK3CG, CREBBP, FLT3
5oligonucleotide4412.6RUNX3, RUNX2, RUNX1, RUNX1T1, FLT3, LIF
6threonine4412.6RUNX1, RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3
7phosphatidylinositol4412.4RUNX2, PIK3CG, CREBBP, FLT3, LIF, MYH11
8zinc44 2413.1RUNX2, RUNX1, RUNX1T1, NPM1, CREBBP, ABL1
9atp44 2813.1NPM1, CREBBP, FLT3, LIF, ABL1, KMT2A
10etoposide44 49 59 1115.0RUNX1, PIK3CG, CREBBP, FLT3, KMT2A, PTPN11
11doxorubicin44 49 1114.0RUNX1, NPM1, PIK3CG, CREBBP, FLT3, KMT2A
12proline4411.9RUNX1, RUNX1T1, CREBBP, ABL1, KMT2A, PTPN11
13imatinib44 49 1113.8RUNX1, PIK3CG, FLT3, ABL1, PTPN11
14herbimycin a44 5912.5PIK3CG, FLT3, ABL1, PTPN11
15phosphotyrosine4411.5PTPN11, ABL1, FLT3, PIK3CG
16sb 20358044 5912.4RUNX2, PIK3CG, LIF, PTPN11
17roscovitine4411.3CREBBP, PIK3CG, RUNX2
18rapamycin4411.3NPM1, PIK3CG, FLT3, PTPN11
19phenylephrine44 28 11 2414.3PIK3CG, CREBBP, LIF
20actinomycin d4411.2KMT2A, LIF, PIK3CG, NPM1
21paclitaxel44 49 1113.2NPM1, PIK3CG, LIF
22gp 1304411.2PTPN11, LIF, FLT3
23pd 98,0594411.1RUNX2, PIK3CG, CREBBP, LIF
24af 104411.1KMT2A, PICALM
25cytarabine44 49 1113.1ABL1, LIF, FLT3
26estrogen4411.0KMT2A
27ag-12964411.0FLT3, PIK3CG
28ly2940024410.9RUNX2, PIK3CG, MYH11, PTPN11

GO Terms for genes affiliated with Myeloid Leukemia

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16Gene Ontology
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Cellular components related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1ERG, RUNX3, RUNX2, RUNX1, NPM1, PICALM
2cytoplasmGO:00573712.5CREBBP, PIK3CG, NPM1, RUNX2, RUNX3, MLF1
3nuclear chromatinGO:00079011.1CREBBP, RUNX2, RUNX3

Biological processes related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589311.6KMT2A, CREBBP, PICALM, RUNX1, RUNX2
2myeloid progenitor cell differentiationGO:00231811.3MLF1, FLT3, RUNX1
3cell maturationGO:04846911.3CBFB, RUNX2, RUNX3
4hemopoiesisGO:03009711.3RUNX1, PICALM, FLT3
5axon guidanceGO:00741111.2RUNX3, MYH11, ABL1, PTPN11
6peripheral nervous system neuron developmentGO:04893511.0RUNX3, RUNX1
7regulation of cell adhesion mediated by integrinGO:03362811.0PTPN11, PIK3CG
8protein complex assemblyGO:00646111.0KMT2A, CREBBP, PICALM
9definitive hemopoiesisGO:06021610.9CBFB, RUNX1
10myeloid cell differentiationGO:03009910.9CBFB, RUNX1
11regulation of endocytosisGO:03010010.6ABL1, PICALM

Molecular functions related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.7ERG, RUNX3, RUNX2, RUNX1, RUNX1T1, MRVI1
2sequence-specific DNA binding transcription factor activityGO:00370011.9RUNX3, RUNX2, RUNX1, RUNX1T1, CREBBP, CBFB
3ATP bindingGO:00552411.5RUNX3, RUNX2, RUNX1, PIK3CG, FLT3, MYH11
4protein homodimerization activityGO:04280311.4KMT2A, FLT3, NPM1, RUNX1T1, RUNX1

Products for genes affiliated with Myeloid Leukemia

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  • Antibodies
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Sources for Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet