MCID: MYL006
MIFTS: 72

Myeloid Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Immune diseases, Blood diseases categories

Summaries for Myeloid Leukemia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards: Myeloid Leukemia, also known as other myeloid leukemia, is related to acute myeloid leukemia and leukemia. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Notch Signaling Pathways and TGF-beta Signaling Pathways. The compounds gp 130 and ponatinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and craniofacial.

Aliases & Classifications for Myeloid Leukemia

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9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 23GTR, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 26ICD10
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Classifications:



Aliases & Descriptions:

myeloid leukemia 9 44 46 63
other myeloid leukemia 9 63
leukemia, myeloid 44 23
unspecified myeloid leukemia without mention of remission 9
myeloid leukemia, nos, without mention of remission 9
other myeloid leukemia without mention of remission 9
unspecified myeloid leukemia in remission 9
other myeloid leukemia in remission 9
myeloid leukemia, no icd-o subtype 9
myelogenous leukemia in remission 9
myeloid leukemia in remission 9
myeloid granulocytic leukemia 9
other myeloid leukemia nos 9
myeloid leukemia, disease 9
non-lymphocytic leukemia 9
leukemia myelogenous 9
myeloid leukemia nos 9
myeloid leukaemia 9
myeloid leukemias 9


External Ids:

Disease Ontology9 DOID:8692
ICD9CM28 205, 205.9
NCIt41 C3172
ICD1026 C92, C92.7

Related Diseases for Myeloid Leukemia

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18GeneCards, 19GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
myeloid leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
Acute Myeloid Leukemia with T(9;11)(p22;q23) Acute Myeloid Leukemia with T(8;16)(p11;p13)
Acute Myeloid Leukemia with T(6;9)(p23;q34)

Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 439)
idRelated DiseaseScoreTop Affiliating Genes
1acute myeloid leukemia32.7RUNX1, MLF1, FLT3, CEBPA, NPM1
2leukemia32.6RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, NPM1
3chronic myeloid leukemia32.4RUNX1, ABL1, PTPN11, FLT3, CBFB, CREBBP
4myelodysplastic syndromes31.8RUNX1, ABL1, MLF1, PTPN11, FLT3, CBFB
5acute promyelocytic leukemia31.2RUNX1, RUNX1T1, FLT3, CREBBP, NPM1
6wilms tumor31.1ABL1, FLT3, CREBBP
7chronic myelomonocytic leukemia31.1RUNX1, PTPN11, FLT3
8acute leukemia31.1MLF1, PTPN11, FLT3, CBFB, CEBPA, CREBBP
9myeloproliferative disorder31.0RUNX1, ABL1, PTPN11, FLT3
10refractory anemia31.0FLT3, RUNX1
11down syndrome31.0RUNX1, FLT3, ERG
12acute myeloid leukemia, adult30.9RUNX1, PTPN11, FLT3, NPM1
13breast cancer30.9RUNX3, RUNX1, RUNX2, ABL1, PTPN11, FLT3
14acute lymphocytic leukemia30.7RUNX1, ABL1, PICALM, PTPN11, FLT3, CBFB
15juvenile myelomonocytic leukemia30.6RUNX1, PTPN11, FLT3
16monocytic leukemia30.6LIF, RUNX1
17gastrointestinal stromal tumor30.6MYH11, FLT3, ABL1
18acute myelomonocytic leukemia30.5RUNX1, CBFB, CREBBP
19cleidocranial dysplasia30.1RUNX3, RUNX1, RUNX2, CBFB
20retinoblastoma30.1NPM1, CREBBP, CEBPA, ABL1, RUNX2, RUNX1
21colon cancer30.1CREBBP, PTPN11, ABL1, RUNX1, RUNX3
22cytogenetically normal acute myeloid leukemia10.8
23core binding factor acute myeloid leukemia10.8
24sarcoma10.8
25myeloid sarcoma10.7
26hematopoietic stem cell transplantation10.7
27endotheliitis10.7
28lymphoblastic leukemia10.7
29neutropenia10.6
30mastocytosis10.6
31systemic mastocytosis10.6
32graft versus host disease10.5
33subacute myeloid leukemia10.5
34myelofibrosis10.5
35tetraploidy10.5
36acute myeloid leukemia with multilineage dysplasia10.5
37thrombocytosis10.5
38diphtheria10.5
39aspergillosis10.5
40polycythemia10.5
41essential thrombocythemia10.5
42mn110.5
43philadelphia-negative chronic myeloid leukemia10.5
44diabetes insipidus10.5
45mediastinitis10.5
46familial acute myeloid leukemia with mutated cebpa10.5
47polycythemia vera10.5
48chronic lymphocytic leukemia10.5
49thrombocytopenia10.5
50refractory anemia with excess blasts10.5

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Symptoms for Myeloid Leukemia

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Drugs & Therapeutics for Myeloid Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Search CenterWatch for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

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23GTR
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Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia23

Anatomical Context for Myeloid Leukemia

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34MalaCards
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MalaCards organs/tissues related to Myeloid Leukemia:

34
Myeloid, Bone, Bone marrow, T cells, Monocytes, Endothelial, B cells, Breast, Lung, Testis, Nk cells, Testes, Skin, Colon, Kidney, Thyroid, Lymph node, Liver, Brain, Eye, B lymphoblasts, Spleen, Heart, Smooth muscle, Tonsil, Small intestine, Placenta, Pancreas, Pituitary

Animal Models for Myeloid Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Myeloid Leukemia:

38 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8RUNX1, PTPN11, FLT3, CBFB, CEBPA, CREBBP
2MP:00053829.8CREBBP, CBFB, PTPN11, ABL1, RUNX2
3MP:00030129.7RUNX3, RUNX1, RUNX2, PTPN11, CBFB, CEBPA
4MP:00053759.7RUNX3, PTPN11, LIF, CEBPA, CREBBP
5MP:00053919.6RUNX2, ABL1, PTPN11, LIF, CBFB, CEBPA
6MP:00053909.6RUNX3, RUNX1, RUNX2, ABL1, PTPN11, LIF
7MP:00053709.5RUNX1, RUNX2, ABL1, PICALM, PTPN11, LIF
8MP:00028739.5RUNX1, RUNX1T1, ABL1, PTPN11, CEBPA, CREBBP
9MP:00053809.4RUNX1, ABL1, PICALM, PTPN11, LIF, CBFB
10MP:00053889.4ABL1, RUNX2, RUNX1, RUNX3, PTPN11, MYH11
11MP:00053799.4RUNX3, RUNX2, PTPN11, LIF, CEBPA, CREBBP
12MP:00053699.4RUNX3, RUNX2, ABL1, MRVI1, PTPN11, MYH11
13MP:00107719.3RUNX3, RUNX1, RUNX1T1, RUNX2, PTPN11, MYH11
14MP:00036319.2RUNX3, RUNX1, RUNX2, ABL1, PTPN11, LIF
15MP:00053819.2RUNX3, RUNX1T1, RUNX2, ABL1, MRVI1, PTPN11
16MP:00053769.2PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
17MP:00053849.2PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
18MP:00053979.0PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
19MP:00053879.0PICALM, ABL1, RUNX2, RUNX1, RUNX3, PTPN11
20MP:00053858.9RUNX1, RUNX1T1, RUNX2, ABL1, MRVI1, PTPN11
21MP:00053788.8NPM1, RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1
22MP:00107688.6PICALM, MRVI1, ABL1, RUNX2, RUNX1T1, RUNX1

Publications for Myeloid Leukemia

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53PubMed
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Articles related to Myeloid Leukemia:

(show top 50)    (show all 4654)
idTitleAuthorsYear
1
Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. (24413389)
2014
2
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
3
Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. (24120526)
2014
4
Intraventricular hemorrhage in a patient with chronic myeloid leukemia and anterior communicating artery aneurysm. (23860156)
2013
5
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. (24035334)
2013
6
Treatment-, patient-, and disease-related factors and the emergence of adverse events with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia. (23553655)
2013
7
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. (23912609)
2013
8
Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as T-cell lymphoblastic lymphoma. (23486000)
2013
9
Mobilization of CD34(+)CD38(-) hematopoietic stem cells after priming in acute myeloid leukemia. (24179607)
2013
10
Dasatinib: a guide to its use in chronic myeloid leukemia in the EU. (23549840)
2013
11
Prognostic implication of BAALC gene expression in adult acute myeloid leukemia. (23865362)
2013
12
CAR T cells for acute myeloid leukemia: the LeY of the land. (24201214)
2013
13
Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells. (23878608)
2013
14
Interferon I+ may be back on track to treat acute myeloid leukemia. (23734314)
2013
15
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. (22929312)
2012
16
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
17
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-I_B and underlies its chemo-resistance. (23077289)
2012
18
High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group. (22915059)
2012
19
Synergistic effect of 5-azacytidine and NF-I_B inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells. (24139415)
2012
20
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. (22490330)
2012
21
DNMT3A mutations are rare in childhood acute myeloid leukemia. (21685466)
2011
22
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (21951951)
2011
23
Summary of 615 patients of chronic myeloid leukemia in Shanghai from 2001 to 2006. (20199658)
2010
24
A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. (21156465)
2010
25
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. (19637342)
2009
26
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
27
Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (18768433)
2008
28
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. (18616510)
2008
29
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells. (18268283)
2008
30
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. (18401414)
2008
31
Analysis of NPM1 gene mutations in acute myeloid leukemia]. (17877154)
2007
32
Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. (17822317)
2007
33
Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. (17064874)
2007
34
Adenomatoid tumor of the testis in a patient on imatinib therapy for chronic myeloid leukemia. (16923575)
2006
35
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells. (15744347)
2005
36
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (15840695)
2005
37
Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. (15034867)
2004
38
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (12393722)
2003
39
Acute myeloid leukemia associated with necrotizing temporal arteritis. (12672210)
2003
40
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
41
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
42
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. (12145683)
2002
43
Drug therapy of chronic myeloid leukemia]. (11831070)
2002
44
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
45
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. (11568008)
2001
46
Cytokine expression of T cells in chronic myeloid leukemia. (11775253)
2000
47
Induction of gp130 and LIF by differentiation inducers in human myeloid leukemia K562 cells. (10613356)
1999
48
Rearrangements and fusion gene of AML1 and MTG8 in acute myeloid leukemia M2b]. (7553157)
1995
49
Regulation of the expression of vimentin gene during the differentiation of mouse myeloid leukemia cells. (1970825)
1990
50
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984

Variations for Myeloid Leukemia

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Expression for genes affiliated with Myeloid Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Leukemia

Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

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51PathCards, 55R&D Systems, 5Cell Signaling Technology, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 56Reactome
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Compounds for genes affiliated with Myeloid Leukemia

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1gp 1304610.3PTPN11, FLT3, LIF
2ponatinib52 1211.3FLT3, ABL1
3tgf beta14610.3LIF, FLT3, RUNX2
4agarose4610.3FLT3, LIF, NPM1
5cytarabine46 52 1212.3ABL1, FLT3, LIF
6etoposide46 52 62 1213.3CREBBP, FLT3, PTPN11, RUNX1
7imatinib46 52 1212.2FLT3, PTPN11, ABL1, RUNX1
8doxorubicin46 52 1212.2NPM1, CREBBP, FLT3, RUNX1
9herbimycin a46 6211.2FLT3, PTPN11, ABL1
10fatty acid4610.1RUNX2, LIF, CEBPA, CREBBP, NPM1
11proline4610.1RUNX1, RUNX1T1, ABL1, PTPN11, CREBBP
12thymidine46 2511.1RUNX2, PTPN11, FLT3, LIF
13nitric oxide46 25 1212.0RUNX2, PTPN11, MYH11, LIF, CREBBP
14zinc46 2511.0RUNX1, RUNX1T1, RUNX2, ABL1, CREBBP, NPM1
15cisplatin46 52 62 1212.9CREBBP, LIF, PTPN11, ABL1
16atp46 3010.9ABL1, PTPN11, FLT3, LIF, CREBBP, NPM1
17threonine469.9RUNX1, RUNX1T1, ABL1, PTPN11, FLT3, CREBBP
18phosphatidylinositol469.8RUNX2, ABL1, PTPN11, FLT3, MYH11, LIF
19estrogen469.8RUNX2, ABL1, MYH11, LIF, CEBPA, CREBBP
20glucose469.8CREBBP, CEBPA, LIF, PTPN11, RUNX2
21oligonucleotide469.8RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, PTPN11
22oxygen46 2510.7RUNX2, ABL1, PTPN11, LIF, CREBBP
23vegf469.6RUNX3, RUNX1, RUNX2, ABL1, PTPN11, FLT3
24serine469.6RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, PTPN11
25tyrosine469.6RUNX1, RUNX2, ABL1, PTPN11, FLT3, LIF
26retinoic acid46 2510.5NPM1, RUNX3, RUNX1, RUNX2, ABL1, FLT3
27cysteine469.4ABL1, PTPN11, LIF, CREBBP, NPM1
28calcium46 52 25 1212.3RUNX2, ABL1, MRVI1, PTPN11, LIF, CREBBP

GO Terms for genes affiliated with Myeloid Leukemia

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17Gene Ontology
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Cellular components related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00079010.1CREBBP, RUNX2, RUNX3
2nucleusGO:0056348.5NPM1, RUNX3, RUNX1, RUNX2, ABL1, PICALM
3cytoplasmGO:0057378.3MLF2, MLF1, ABL1, RUNX2, RUNX3, PTPN11

Biological processes related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system neuron developmentGO:04893510.4RUNX3, RUNX1
2myeloid cell differentiationGO:03009910.3RUNX1, CBFB, CEBPA
3myeloid progenitor cell differentiationGO:00231810.3FLT3, MLF1, RUNX1
4hemopoiesisGO:03009710.3FLT3, PICALM, RUNX1
5definitive hemopoiesisGO:06021610.3CBFB, RUNX1
6hair follicle morphogenesisGO:03106910.3RUNX1, RUNX3
7cell maturationGO:04846910.2CEBPA, CBFB, RUNX2, RUNX3
8regulation of endocytosisGO:03010010.1PICALM, ABL1
9axon guidanceGO:00741110.0MYH11, PTPN11, ABL1, RUNX3
10transcription from RNA polymerase II promoterGO:00636610.0RUNX3, LIF, CBFB, CEBPA, ERG
11negative regulation of cell proliferationGO:0082859.9FLT3, LIF, CEBPA, NPM1
12positive regulation of transcription, DNA-templatedGO:0458939.7RUNX1, RUNX2, PICALM, CREBBP

Molecular functions related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1repressing transcription factor bindingGO:07049110.3RUNX2, RUNX1
2protein homodimerization activityGO:0428039.9RUNX1, RUNX1T1, FLT3, CEBPA, NPM1
3protein domain specific bindingGO:0199049.7PTPN11, MLF1, RUNX2
4sequence-specific DNA binding transcription factor activityGO:0037009.7RUNX3, RUNX1, RUNX1T1, RUNX2, CBFB, CEBPA
5ATP bindingGO:0055249.6RUNX3, RUNX1, RUNX2, ABL1, FLT3, MYH11
6DNA bindingGO:0036779.5RUNX1, RUNX1T1, ABL1, MLF1, CBFB, CEBPA
7protein bindingGO:0055158.2NPM1, RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1

Products for genes affiliated with Myeloid Leukemia

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  • Antibodies
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Sources for Myeloid Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet