Myeloid Leukemia malady

Wikipedia: Myeloid leukemia is a type of leukemia affecting myeloid tissue.⁴⁴ more...

MalaCards: Myeloid Leukemia, also known as other myeloid leukemia, is related to leukemia and carcinoma. An important gene associated with Myeloid Leukemia is MLF1 (myeloid leukemia factor 1), and among its related pathways are G12-G13 in Cellular Signaling and Chemotaxis_CXCR4 signaling pathway. The drugs isotretinoin and pipobroman and the compounds cholesterol and calcium have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are skeleton and normal.

Aliases & Descriptions:

myeloid leukemia 6 7 30 32 43 other myeloid leukemia 6 43 myeloid leukemia, no icd-o subtype (morphologic abnormality) 6 unspecified myeloid leukemia without mention of remission 6 other myeloid leukemia nos (morphologic abnormality) 6 other myeloid leukemia without mention of remission 6 myeloid leukemia, nos, without mention of remission 6 other myeloid leukemia (morphologic abnormality) 6 myeloid leukemias (morphologic abnormality) 6 unspecified myeloid leukemia in remission 6 myeloid leukemia in remission (disorder) 6 other myeloid leukemia nos (disorder) 6 myeloid leukemia, disease (disorder) 6 other myeloid leukemia in remission 6

other myeloid leukemia (disorder) 6 myelogenous leukemia in remission 6 myeloid leukemia nos (disorder) 6 myeloid granulocytic leukemia 6 myeloid leukaemia (category) 6 myeloid leukemia (disorder) 6 myeloid leukemia, disease 6 non-lymphocytic leukemia 6 leukemia myelogenous 6 myelogenous leukemia 7 myeloid leukaemia 6 leukemia, myeloid 30 leukemia 43

Diseases related to myeloid leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 958)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	251.5	ZNF673, ZNF296, PIK3CB, PIK3CD, PIM2, PIK3CA
2	carcinoma	183.6	ZNF673, PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R3
3	prostatitis	157.1	ZNF673, PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R3
4	neuronitis	146.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	melanoma	137.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
6	pancreatitis	136.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
7	adenocarcinoma	132.7	PIK3CB, PIM2, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
8	hepatocellular carcinoma	127.6	PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1, PIK3CG
9	thyroiditis	121.8	PIK3CB, PIK3CA, PIK3R1, PICALM, PIK3C2A, PIK3CG
10	gastric cancer	117.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, PIM1
11	lymphoblastic leukemia	116.4	PIK3CA, PICALM, PIK3CG, LRP5, KLF5, NCAM1
12	myeloma	114.0	PIM2, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP5
13	sarcoma	113.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIAS4
14	neuroblastoma	112.6	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
15	lymphocytic leukemia	111.6	PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCL
16	colon cancer	111.2	PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, KLF5
17	cervicitis	109.7	PIK3CA, PIK3CG, PIN1, NCL, NCR1, NCR2
18	arthritis	109.3	PIK3CD, PIK3CG, PIN1, LRP5, KLF5, PDCD1
19	hypoxia	107.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3C2A
20	esophagitis	107.1	ZNF673, PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1
21	acute leukemia	106.0	PIK3CA, PICALM, SH3GL1, NCAM1, NCL, NCOA2
22	rheumatoid arthritis	104.2	PIK3CD, PIK3CG, PIN1, LRP5, KLF5, PDCD1
23	multiple myeloma	102.4	PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1, NCOR2
24	alzheimer's disease	94.0	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PICALM, PIK3CG
25	fibrosis	92.1	PIK3CA, PIK3CG, PIN1, KLF6, NCOA3, RECK
26	ovarian carcinoma	91.2	PIK3CA, PIK3CG, NCOA3, PDCD5, RECK, RELA
27	squamous cell carcinoma	90.5	PIK3CB, PIK3CA, PIN1, PIM1, NCL, NCOA3
28	cholesterol	90.1	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
29	chronic myeloid leukemia	89.8	PIK3CG, KIT, KITLG, KIR3DL1, PCBP2, SELP
30	adenoma	89.1	PIK3CA, NCAM1, NCOA2, NCOA3, NCOR1, NCOR2
31	anemia	88.3	PIM1, KLF1, KLF2, NCAM1, NCOR1, PDCD1
32	colon carcinoma	87.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KLF5
33	cervical cancer	87.4	PIK3CA, PIK3CG, PIN1, NCL, NCR1, NCR2
34	lupus erythematosus	84.6	PIK3CD, PIK3C2A, PIK3CG, NCL, NCR3, PDCD1
35	lung carcinoma	84.1	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
36	retinitis	84.0	PIK3CA, PIK3C2A, PIK3CG, PIM1, LRP5, KLF6
37	osteosarcoma	83.7	PIK3CB, PIK3CA, PIK3CG, LRP5, RECK, RELA
38	cerebritis	83.2	PIK3R1, PIK3C2A, PIK3CG, KLF6, NDE1, NCAM1
39	asthma	81.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
40	tuberculosis	81.6	PIM2, PIK3CG, PIM1, NCR1, PDCD1, RELA
41	multiple sclerosis	81.0	NCAM1, PDCD1, RELA, KIR2DS3, KIR2DS5, KIR3DL2
42	retinoblastoma	79.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6
43	hematopoiesis	78.3	PIK3CB, PIK3R1, PIK3CG, PIM1, KLF3, NCOA3
44	astrocytoma	75.8	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
45	hypertension	75.6	PIK3CB, PIK3R1, PIK3C2A, PIK3CG, PIM1, LRP5
46	acute lymphoblastic leukemia	72.4	PICALM, RECK, KIT, KITLG, KIR3DL1, RB1
47	thyroid carcinoma	71.5	PIK3CA, PIK3CG, KIR3DL2, KITLG, PCNA, RB1
48	influenza	70.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
49	obesity	70.3	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP5
50	leukemia/lymphoma	69.4	PIM2, PIK3CA, PIK3CG, PDCD1, KITLG, BUB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cytarabine, cytarabine liposome, doxorubicin hydrochloride, irinotecan, irinotecan hydrochloride, isotretinoin, methotrexate, methotrexate sodium, pipobroman, vincristine, vincristine sulfate

MalaCards organs/tissues related to myeloid leukemia:

²²

MGI Mouse Phenotypes related to myeloid leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	INF	PIK3CD, PIK3CG, KLF2, RECK, RELA, KIT
2	normal phenotype	MP:0002873	INF	PIK3R1, LRP5, KLF2, KLF3, KLF5, NCR1
3	no phenotypic analysis	MP:0003012	INF	PIK3CD, PIK3R1, RFWD2, NCOA2, SFRP1, SFRP2
4	nervous system phenotype	MP:0003631	INF	LRP5, NDE1, NCOR1, PDCD1, RECK, RELA
5	adipose tissue phenotype	MP:0005375	INF	PIK3CA, PIK3R1, PIK3C2A, KLF3, NCOA3, NCOR1
6	growth/size phenotype	MP:0005378	INF	PIK3CB, PIM2, PIK3CA, PIK3R1, PIR, PICALM
7	renal/urinary system phenotype	MP:0005367	INF	KLF1, NCOA3, PDCD1, REN, KIT, SELP
8	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRP5, NCAM1, NCOA2, NCOA3, NCOR1
9	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, KLF1, KLF6, RFWD2, NCOA2
10	reproductive system phenotype	MP:0005389	INF	PIK3CA, KLF6, RFWD2, NCOA2, NCOA3, REN
11	embryogenesis phenotype	MP:0005380	INF	PIK3CB, PIK3CA, PIR, PICALM, LRP5, KLF1
12	endocrine/exocrine gland phenotype	MP:0005379	22.0	LRP5, KLF5, RFWD2, NCOA2, SFRP2, SFRP5
13	pigmentation phenotype	MP:0001186	17.3	LRP5, RFWD2, KIT, KITLG, RB1, BRAF
14	other phenotype	MP:0005395	16.2	RECK, BUB1, RARG, RARA, RARB, PBX1
15	cardiovascular system phenotype	MP:0005385	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
16	tumorigenesis	MP:0002006	INF	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RFWD2, NCOA3
17	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PICALM
18	liver/biliary system phenotype	MP:0005370	INF	PICALM, LRP5, KLF1, KLF2, KLF6, NCOA3
19	hematopoietic system phenotype	MP:0005397	INF	PIM2, PIAS4, PICALM, PIM1, KLF1, KLF2
20	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R2, PIK3R1, PIK3CG, KLF2, KLF5
21	immune system phenotype	MP:0005387	INF	PIK3CD, PIM2, PIAS4, PIK3R5, PICALM, LRP5
22	digestive/alimentary phenotype	MP:0005381	INF	KLF5, NCOA3, NCOR2, KIT, KITLG, VWF
23	craniofacial phenotype	MP:0005382	INF	LRP5, KLF2, NCOA3, NCOR2, KIT, KITLG
24	respiratory system phenotype	MP:0005388	INF	KLF2, KLF5, SELL, SELP, NAB1, BRCA1
25	limbs/digits/tail phenotype	MP:0005371	INF	LRP5, RECK, RELA, KIT, KITLG, SFRP1
26	vision/eye phenotype	MP:0005391	INF	PIK3CA, PIN1, LRP5, NCAM1, PDCD1, RELA
27	hearing/vestibular/ear phenotype	MP:0005377	INF	NCOA3, KIT, KITLG, RB1, VDR, LMNA
28	cellular phenotype	MP:0005384	INF	PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1, PIK3R5
29	mortality/aging	MP:0010768	INF	PIK3CB, PIK3CA, PIAS4, PICALM, PIK3C2A, LRP5

Articles related to myeloid leukemia:

(show top 50)    (show all 2704)

id	Title	Authors	Year	Affiliating Genes
1	Functional variant (-1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chin ese population. (21518142)	Jiang L.... Zhou Y.	2011	MAP2K4
2	Low expression of MN1 associates with better treatmen t response in older patients with de novo cytogenetically normal acute myeloid leukemia. (21828125)	Schwind S.... Bloomfield C.D.	2011	MN1
3	Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Phi ladelphia-negative cells. (20471511)	Larsson N.... Fioretos T.	2010	PTPN11, NRAS, KRAS
4	IDH1 and IDH2 mutations are frequent genetic alterati ons in acute myeloid leukemia and confer adverse prognosis in cytogenetically n ormal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem du plication. (20567020)	Paschka P.... DAPhner K.	2010	IDH1, IDH2
5	Prevalence and prognostic implications of WT1 mutatio ns in pediatric acute myeloid leukemia (AML): a report from the Children's Onco logy Group. (20413658)	Ho P.A.... Meshinchi S.	2010	WT1
6	Quantification of the PRAME transcripts in patients with acute myeloid leukemia (20376794)	Zhu Z.H.... Xiao G.	2010	PRAME
7	Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leuk emia French Association group. (20625116)	Boissel N.... Preudhomme C.	2010	IDH1, IDH2
8	Sustained molecular response with interferon alfa mai ntenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia. (20142590)	Burchert A.... Hochhaus A.	2010	IFNA1
9	Novel RUNX1 mutations in familial platelet disorder w ith enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome. (19946261)	Jongmans M.C.... Hoogerbrugge N.	2010	RUNX1
10	Dasatinib inhibits the growth of molecularly heteroge neous myeloid leukemias. (20145167)	Guerrouahen B.S.... Corey S.J.	2010	KIT, FLT3
11	Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group. (19047294)	BA1chner T.... Hiddemann W.	2009	FLT3, NPM1
12	Differential methylation pattern of ID4, SFRP1, and S HP1 between acute myeloid leukemia and chronic myeloid leukemia. (19543515)	Uhm K.O.... Park S.H.	2009	PTPN6, SFRP1, ID4
13	Transforming growth-interacting factor (TGIF) regulat es proliferation and differentiation of human myeloid leukemia cells. (19699159)	Hamid R.... Brandt S.J.	2009	TGIF1
14	FLT3-ITD up-regulates MCL-1 to promote survival of st em cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. (19808698)	Yoshimoto G.... Akashi K.	2009	FLT3, MCL1
15	Inhibition of MDR1 does not sensitize primitive chron ic myeloid leukemia CD34+ cells to imatinib. (19394750)	Hatziieremia S.... rgensen H.G.	2009	ABCB1
16	FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia. (17967943)	Kim H.G.... Klug C.A.	2008	MYH11
17	Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (18450602)	Schlenk R.F.... Dohner H.	2008	FLT3, MLL, NRAS
18	Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. (18207572)	Muller P.... Rund D.	2008	NAT1, ABCG2, GSTT1
19	Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. (18270328)	Tomasson M.H.... Ley T.J.	2008	NTRK1, KIT, JAK2
20	Clinical significance of GSTM1 and GSTT1 polymorphisms in younger patients with acute myeloid leukemia of intermediate-risk cytogenetics. (18760837)	Lee H.S.... Lee K.H.	2008	GSTT1, GSTM1
21	Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD. (17881646)	Bunting K.D.... Hsi E.D.	2007	FLT3, STAT5B
22	Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. (17284714)	Hershman D.... Grann V.R.	2007	CSF3
23	Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand. (17258890)	Guilloton F.... Quillet-Mary A.	2007	GZMB, FASLG, MAP3K5
24	Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. (17097559)	Deshpande A.J.... Buske C.	2006	PICALM
25	An association between manganese superoxide dismutase polymorphism and outcome of chemotherapy in acute myeloid leukemia. (16769586)	Koistinen P.... Savolainen E.R.	2006	SOD2
26	NUP98 is fused to topoisomerase (DNA) IIbeta 180 kDa (TOP2B) in a patient with acute myeloid leukemia with a new t(3;11)(p24;p15). (16166424)	Nebral K.... Strehl S.	2005	NUP98
27	Breast cancer resistance protein in drug resistance of primitive CD34+38- cells in acute myeloid leukemia. (15788695)	Raaijmakers M.H.... Raymakers R.A.	2005	ABCG2
28	Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). (15345593)	Kindler T.... Fischer T.	2005	FLT3, STAT5A
29	Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. (15187020)	Shetzline S.E.... Gewirtz A.M.	2004	MYB, NMU, NMUR1
30	A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. (12461747)	Wechsler D.S.... Roulston D.	2003	MLL, PICALM, MLLT10
31	Iron overload in acute myeloid leukemia patients is not related to HFE and TFR2 gene mutations. (12969816)	Veneri D.... Pizzolo G.	2003	TFR2
32	High incidence of autoimmune alterations in chronic myeloid leukemia patients treated with interferon-alpha. (12605388)	Steegmann J.L.... FernA!ndez RaA+ada J.M.	2003	IFNA1
33	A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia. (12384447)	Spiekermann K.... Schnittger S.	2002	FLT3
34	The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. (11222388)	Smolich B.D.... Cherrington J.M.	2001	KIT, VEGFA, KITLG
35	The CDCREL1 gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) and its frequent expression in myeloid leukemia cell lines. (11170279)	Tatsumi K.... Hayashi Y.	2001	MLL
36	Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL. (11222392)	Li S.... Van Etten R.A.	2001	IL3, CSF2, CSF3
37	Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience. (11698272)	Petersdorf E.W.... McGlave P.	2001	HLA-DPA1
38	Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome. (10719368)	Streubel B.... Fonatsch C.	2000	MLL
39	The immunophenotype of 177 adults with acute myeloid leukemia: proposal of a prognostic score. (10910899)	Legrand O.... Marie J.P.	2000	ANPEP, MPO
40	Hematological and cytogenetic response of interferon alpha 2b alone and combined interferon alpha plus cytarabine as a first-line treatment in chronic myeloid leukemia. (10985480)	TA^thovA! E.... HlebaskovA! M.	2000	IFNA2, IFNA1
41	Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1. (10100620)	Hwang E.S.... Lee S.K.	1999	MKL1
42	Long-term follow-Up of the italian trial of interferon-alpha versus conventional chemotherapy in chronic myeloid leukemia. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. (9716581)		1998	IFNA1
43	In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation. (9714703)	Beghini A.... Larizza L.	1998	KIT
44	Effect of WT1 gene expression on cell growth and proliferation in myeloid leukemia cell lines (11263329)	Mi Y.... Bian S.	1998	WT1
45	Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group. (9362160)		1997	IFNA1
46	Vesnarinone exhibits antitumor effect against myeloid leukemia cells via apoptosis. (9328455)	Fujiwara H.... Tanaka H.	1997	MYC
47	Interferon-alpha and hydroxyurea in early chronic myeloid leukemia: a comparative analysis of the Italian and German chronic myeloid leukemia trials with interferon-alpha. (8652857)	Hasford J.... Zuffa E.	1996	IFNA1
48	Correlation of multidrug resistance (MDR1) protein ex pression with functional dye/drug efflux in acute myeloid leukemia by multipara meter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflu x- cases. (7545025)	Leith C.P.... Willman C.L.	1995	ABCB1
49	Treatment of Ph-positive chronic myeloid leukemia with alpha-interferon (ROFERON-A). The Italian Cooperative Study Group experience. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. (8251889)		1993	IFNA2, IFNA1
50	Self-renewal inhibition of acute myeloid leukemia clonogenic cells by biological inducers of differentiation. (1372669)	Ferrero D.... Pileri A.	1992	IFNG, CSF3, CSF1

Genes related to myeloid leukemia according to GeneCards:

(show top 50)    (show all 1150)

id	Symbol	Description	Score	GeneCards Section Context
1	MLF1	myeloid leukemia factor 1	11.1	Orthologs, Transcripts, Publications, Domains & Families (show all 7 sections) Aliases & Descriptions, Functions, Summaries
2	PICALM	phosphatidylinositol binding clathrin assembly protein	11.1	Publications, Aliases & Descriptions, Summaries
3	RUNX1	runt-related transcription factor 1	11.1	Publications, Aliases & Descriptions, Domains & Families, Functions (show all 5 sections) Pathways & Interactions
4	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11.1	Publications, Functions, Pathways & Interactions, Orthologs (show all 5 sections) Summaries
5	FLT3	fms-related tyrosine kinase 3	11.1	Publications, Functions, Pathways & Interactions, Summaries
6	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.1	Publications, Summaries
7	CBFB	core-binding factor, beta subunit	11.1	Publications, Functions, Summaries
8	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.1	Publications, Pathways & Interactions, Summaries
9	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	11.1	Publications, Pathways & Interactions, Summaries
10	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	11.1	Publications, Pathways & Interactions, Summaries
11	CREBBP	CREB binding protein	11.1	Publications, Functions, Summaries
12	MRVI1	murine retrovirus integration site 1 homolog	11.1	Summaries, Publications, Functions
13	NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	11.1	Publications, Summaries
14	BAALC	brain and acute leukemia, cytoplasmic	11.1	Publications, Summaries
15	MYH11	myosin, heavy chain 11, smooth muscle	11.1	Publications, Functions, Summaries
16	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	11.1	Publications, Functions, Summaries
17	LIF	leukemia inhibitory factor	11.1	Publications, Functions, Summaries
18	PCM1	pericentriolar material 1	11.1	Publications, Summaries
19	PRDM16	PR domain containing 16	11.1	Publications, Summaries
20	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	11.1	Publications, Aliases & Descriptions, Functions
21	RUNX3	runt-related transcription factor 3	11.1	Publications, Aliases & Descriptions, Domains & Families
22	CLC	Charcot-Leyden crystal protein	11.1	Publications, UniProt Related, Summaries
23	HOXB5	homeobox B5	11.1	Summaries
24	HOXB3	homeobox B3	11.1	Publications, Summaries
25	HOXB6	homeobox B6	11.1	Publications, Summaries
26	ASB2	ankyrin repeat and SOCS box containing 2	11.1	Publications, Summaries
27	CHIC2	cysteine-rich hydrophobic domain 2	11.1	Publications, Summaries
28	YTHDF2	YTH domain family, member 2	11.1	Publications, Summaries
29	ABI1	abl-interactor 1	11.1	Publications, Summaries, Orthologs
30	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	11.1	Publications, Summaries
31	CBFA2T2	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	11.1	Publications, Functions, Summaries
32	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	11.1	Publications, Summaries
33	KAT6B	K(lysine) acetyltransferase 6B	11.1	Publications, Summaries
34	MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	11.1	Publications, Functions, Summaries
35	NSD1	nuclear receptor binding SET domain protein 1	11.1	Publications, Summaries
36	NUP214	nucleoporin 214kDa	11.1	Publications, Summaries
37	MLF2	myeloid leukemia factor 2	11.0	Orthologs, Transcripts, Publications, Aliases & Descriptions (show all 7 sections) Domains & Families, Proteins, Functions
38	SEPT5	septin 5	11.0	Publications, Summaries
39	SEPT6	septin 6	11.0	Publications, Summaries
40	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	11.0	Publications, Summaries
41	RPL22	ribosomal protein L22	11.0	Publications, Summaries
42	AMLCR2	acute myeloid leukemia chromosome region 2	11.0	Aliases & Descriptions
43	SET	SET nuclear oncogene	11.0	Publications, Aliases & Descriptions, Orthologs
44	RUNX2	runt-related transcription factor 2	11.0	Publications, Domains & Families, Aliases & Descriptions
45	LOC100419977	myeloid leukemia factor 2 pseudogene	11.0	Aliases & Descriptions
46	MLRG	Myeloid leukemia-related gene (myeloid tumor suppressor)	11.0	Aliases & Descriptions, Publications
47	NRBP1	nuclear receptor binding protein 1	11.0	Publications, Aliases & Descriptions
48	BCR	breakpoint cluster region	11.0	Publications, Pathways & Interactions
49	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
50	MPO	myeloperoxidase	11.0	Publications

Pathways related to myeloid leukemia according to GeneDecks:

(show top 50)    (show all 470)

id	Pathway	Score	Top Affiliating Genes
1	G12-G13 in Cellular Signaling36	INF	PIK3R3, PIK3R2, PIK3R1, VAV1, RAF1, RAC1
2	Chemotaxis_CXCR4 signaling pathway41	INF	VAV1, RAC1, RASA1, JAK2, CDC42, GRB2
3	Chemotaxis CXCR4 signaling pathway10	INF	VAV1, RAF1, RAC1, RASA1, JAK2, CDC42
4	Pathways in cancer20	29.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	Akt Signaling36	23.2	PIK3R3, PIK3R1, PIK3CG, KIT, VEGFC, RAF1
6	Natural killer cell mediated cytotoxicity20	21.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
7	Colorectal Cancer Metastasis36	19.5	PIK3R3, PIK3R2, PIK3R1, LRP5, BRAF, MYC
8	T cell receptor signaling pathway20	18.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
9	Regulation of eIF4 and p70S6K36	17.8	PIK3R3, PIK3R2, PIK3R1, VEGFC, BAX, CD2
10	Development_FGFR signaling pathway41	16.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
11	Development FGFR signaling pathway10	16.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
12	Immune response CD16 signaling in NK cells10	16.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
13	Development Endothelin-1/EDNRA signaling10	16.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14	Development Endothelin-1/EDNRA transactivation of EGFR10	16.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
15	Cell adhesion_PLAU signaling41	16.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
16	NGF Pathway36	15.9	PIK3R3, PIK3R2, PIK3R1, BRAF, MYC, RAP1A
17	VEGF Signaling Pathway34	15.7	PIK3C2A, VEGFA, VEGFC, RAF1, KDR, ITGAV
18	Development_VEGF-family signaling41	15.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
19	Insulin Receptor Pathway36	15.4	PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, RAC2
20	Development_A3 receptor signaling41	15.3	PIK3R5, PIK3CG, RELA, MYC, RASGRF1, RAF1
21	Transcription_PPAR Pathway41	15.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
22	Development_FGF-family signaling41	15.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
23	Cell adhesion PLAU signaling10	14.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
24	CNTF Signaling36	14.7	PIK3R3, PIK3R2, PIK3R1, RAF1, LIFR, JAK1
25	Development TGF-beta receptor signaling10	14.6	RELA, RAF1, CHUK, XIAP, CDKN1A, CDKN2B
26	Development_Growth hormone signaling via PI3K/AKT and MAPK cascades41	14.5	PIK3R1, CEBPB, JUN, JUNB, JAK2, FOS
27	Development Angiotensin signaling via PYK210	14.5	PIK3R3, PIK3R2, PIK3R1, VAV1, RAF1, RAC1
28	Colorectal cancer20	14.5	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, PIK3R5
29	Development_Angiotensin signaling via PYK241	14.4	PIK3R3, PIK3R2, PIK3R1, VAV1, RAF1, RAC1
30	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	14.4	RELA, BIRC2, CHUK, BAX, JUN, IL2
31	Transcription PPAR Pathway10	14.3	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, NCOR1
32	TNF Signaling36	14.3	BID, BIRC2, BIRC3, CHUK, ATF1, JUN
33	BRCA1 Pathway36	14.0	RB1, BRCA1, BRCA2, RAD51, RAD50, CHEK1
34	Cell cycle_ESR1 regulation of G1/S transition41	13.9	NCOA3, RB1, RBL2, MYC, UBC, JUN
35	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	13.7	RELA, MYC, RAF1, BCL2, BAX, JUN
36	Adherens junction20	13.7	RAC1, RAC2, LEF1, CDC42, CDH1, MLLT4
37	G-protein signaling_Ras family GTPases in kinase cascades (scheme)41	13.7	BRAF, RAP1A, RAF1, RAC1, CEBPB, JUN
38	Apoptotic Pathways Triggered By HIV136	13.5	BID, BIRC2, BIRC3, BCL2, BCL2L1, CHUK
39	Cell cycle Cell cycle (generic schema)10	13.3	RB1, RBL2, RBL1, CDK6, CDK2, CDC25C
40	Development EGFR signaling pathway10	11.3	CBL, DUSP4
41	NFAT in Immune Response36	INF	PIK3R3, PIK3R2, PIK3R1, KIT, KITLG, VEGFC
42	Signal transduction_PTEN pathway41	INF	PCNA, ITGB1, CASP9, TSC2,
43	ERK5 Signaling36	INF	KIT, KITLG, VEGFC, MYC, BMP6, KDR
44	Immune response_IL-6 signaling pathway41	INF	RELA, RAF1, CEBPB, CEBPD, JUN, JUND
45	GDNF-Family Ligands and Receptor Interactions36	INF	PIK3R3, PIK3R2, PIK3R1, RAF1, RASA1, JUN
46	Signal transduction PTEN pathway10	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
47	Development Prolactin receptor signaling10	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
48	Renin-Angiotensin Pathway36	INF	PIK3R3, PIK3R2, PIK3R1, REN, KIT, KITLG
49	Nanog in Mammalian ESC Pluripotency36	INF	KIT, KITLG, BRAF, VEGFC, BMP6, RAF1
50	TGF-beta Signaling Pathways37	INF	PIK3CB, PIK3CD, PIK3R2, PIK3R1, PIK3CG, NCOR1

Compounds related to myeloid leukemia according to GeneDecks:

(show top 50)    (show all 417)

id	Compound	Score	Top Affiliating Genes
1	cholesterol32 9 18 9	INF	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, LRP5, NCOA2
2	calcium32 9 18 9	INF	PIK3CD, PIK3C2A, PIN1, PIM1, LRP5, NCL
3	gtp32	INF	PIK3CA, PIK3R1, PIK3C2A, RECK, SEPT9, BRAF
4	hyaluronic acid32 18	INF	VTN, VIM, MYC, BMP6, RAC1, B2M
5	cytochalasin d32 42	INF	PIK3CG, KITLG, VWF, VTN, SELE, SELL
6	arachidonic acid32 9 18 9	INF	PIK3CA, NCAM1, RECK, KITLG, VWF, SELP
7	tamoxifen32 34 9 9	INF	PIK3CA, NCOA2, NCOA3, NCOR1, NCOR2, VTN
8	colchicine32 9 9	INF	PIK3C2A, VIM, BRCA1, PARK2, ITGAL, ITGB2
9	fatty acid32	INF	PIK3C2A, RECK, BRAF, BRCA1, BNIP3, MYB
10	iron32 18	INF	PICALM, PIK3C2A, RECK, KITLG, VIM, MYCN
11	proline32	INF	PIK3R1, PIN1, PIM1, KLF5, VIM, BSG
12	thymidine32 18	INF	PIK3CA, PIK3R1, KIT, KITLG, PCNA, RB1
13	mg 13232 42	INF	PIK3CG, NCOA2, NCOR2, PCNA, BRCA1, VDR
14	lactacystin32	20.0	PIK3CG, NCOA2, RBL2, RBL1, SELE, BRCA1
15	folate32	18.7	RECK, VWF, SELE, VIM, NAT1, NAT2
16	isoproterenol32 9 9	18.3	PIK3R3, PIK3R2, PIK3R1, SELL, VIM, BRAF
17	caffeine32 34 9 18 9	19.9	PIK3R1, PCNA, NAT1, NAT2, BRCA1, VDR
18	ibmx32	15.8	RAP1A, RARB, RAF1, JUNB, CDK2, CDKN3
19	sulindac32 9 9	17.3	PCNA, BIRC5, BCL2, BCL2L1, BAX, SAT1
20	c2ceramide32	14.7	PIK3CG, BECN1, PARP1, BCL2L1, CHUK, UGCG
21	vincristine32 34 9 9	17.6	NCAM1, RECK, KIT, MYCN, BCL6, UGCG
22	tpck32	14.3	PIK3CG, PARP1, BCL2L1, JUN, IL1B, IL6
23	bryostatin 132	13.8	MYC, RASGRP1, BIRC2, BIRC5, BCL2, BCL2L1
24	phosphoserine32 18	14.8	PIN1, BRCA1, RAF1, BCR, FUCA1, JAK2
25	eb 108932	13.7	PCNA, VDR, PARP1, BCL2, BAX, CDK6
26	quinine32 9 9	15.5	RECK, KCNH2, IL10, IL3, IL4, IDO1
27	fitc32	13.4	VWF, PCNA, SELL, BIRC5, CD86, CD14
28	sp 60012532 42	13.7	PIK3CG, BID, BIK, BIRC2, BIRC3, CDKN1A
29	bisindolylmaleimide32	12.7	PIK3CB, RAF1, RAC1, CFLAR, FOS, MAPK3
30	arsenite32 18	INF	PIK3CA, PIK3R1, PIK3CG, PCNA, VEGFA, VDR
31	anisomycin32 42 9 9	INF	PIK3CG, MYC, RAF1, MTOR, CFLAR, JUN
32	phosphotyrosine32	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RECK, KIT
33	adpribose32	INF	PIK3CA, PIK3CG, PCNA, RB1, BRCA1, BRCA2
34	methionine32	INF	RECK, KIT, VWF, SERPINB2, VIM, MYB
35	rotenone32	INF	PIK3CG, PARP1, PARK2, BCL2, BCL2L1, BAD
36	aspartate32	INF	PIK3R1, PIK3C2A, PIN1, VTN, PCNA, PCNT
37	agarose32	INF	KIT, KITLG, VWF, BRCA1, MYC, MYCN
38	ionomycin32	INF	PIK3CB, PIM1, LMNB1, VAV1, RAP1A, RASGRF1
39	pd 98,05932	INF	PIK3CA, PIK3R1, PIK3CG, NCL, RECK, KIT
40	neopterin32	INF	CHIT1, LCN2, B2M, CD79A, CD14, CD4
41	mannitol32 9 9	INF	SELP, B2M, JAK2, CDC42, CDKN3, CDH1
42	atp32	INF	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIM1, NCAM1
43	irinotecan32 34 9 9	INF	KIT, BRAF, VEGFA, PARP1, BCL2L1, CHEK1
44	vitamin d32	INF	LRP5, NCOA2, NCOA3, NCOR1, NCOR2, VIM
45	glucose32	INF	KIT, BRAF, VEGFC, BNIP3, BID, CLEC12A
46	dihydrotestosterone32 9 18 9	INF	NCOA2, NCOA3, VIM, VDR, BMP6, LEP
47	o6-methylguanine32	INF	PCNA, BRAF, BRCA2, RAD51, RARB, RASSF1
48	ethanol32 34 9 18 9	INF	NCAM1, KITLG, RARB, BID, KCNH2, LEPR
49	indole-3-carbinol32	INF	BRCA1, BRCA2, BIRC5, PARP1, BCL2, BCL2L1
50	sodium nitroprusside32	INF	PIK3C2A, REN, VWF, PCNA, MYB, BMP6

Cellular components related to myeloid leukemia according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	INF	NCAM1, SFRP1, VEGFA, RARA, ULBP2, AXL
2	cytoplasm	GO:005737	INF	PIR, PIAS4, PIK3R5, PIK3C2A, PIK3CG, PIN1
3	perinuclear region of cytoplasm	GO:048471	INF	PICALM, SELE, SET, SEPT9, LPXN, LMNA
4	nucleus	GO:005634	INF	ZNF296, PIK3CB, PIR, PIAS4, PIK3R5, PICALM
5	nucleolus	GO:005730	INF	PIAS4, SH3D19, KLF5, RFWD2, NCL, NCOA3
6	cytosol	GO:005829	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
7	plasma membrane	GO:005886	INF	PIK3CD, PIK3R1, PIK3C2A, PIK3CG, PIM1, LRP5
8	external side of plasma membrane	GO:009897	INF	NCAM1, KIT, VWF, SELL, SELP, KDR
9	nucleoplasm	GO:005654	INF	PIN1, RFWD2, NCOA2, NCOA3, NCOR1, NCOR2
10	transcription factor complex	GO:005667	INF	RELA, RBL2, LMO2, RARG, USF1, BEX1
11	integral to plasma membrane	GO:005887	INF	NCR1, NCR2, NCR3, KIR2DS3, KIR2DS5, KIR3DL2
12	membrane	GO:016020	INF	PIK3R5, PIK3CG, RECK, REN, VEGFA, VEGFC
13	extracellular space	GO:005615	INF	REN, KIT, KITLG, VTN, SFRP1, SFRP2

Biological processes related to myeloid leukemia according to GeneDecks:

(show top 50)    (show all 87)

id	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:006954	INF	PIK3CD, PIK3CG, NCR3, RELA, KIT, SELE
2	cell proliferation	GO:008283	INF	PIM2, PIM1, KITLG, PCNA, BUB1, NBN
3	response to hypoxia	GO:001666	INF	VEGFA, BNIP3, RAF1, USF1, BCL2, SDC2
4	response to lipopolysaccharide	GO:032496	INF	SELE, SELP, CEBPB, JUN, JAK2, MMP9
5	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	PIAS4, NCOA2, NCOR1, NCOR2, VDR, LMO1
6	aging	GO:007568	INF	VDR, JUN, , GSN, GRB2, IL15
7	leukocyte migration	GO:050900	INF	PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELL, SELP
8	innate immune response	GO:045087	INF	PIK3CD, PIK3CG, PIN1, RELA, , VNN1
9	protein phosphorylation	GO:006468	INF	PIK3CD, PIM2, PIM1, BRAF, RARA, RAF1
10	response to organic cyclic compound	GO:014070	INF	SFRP1, SELP, LEF1, MSH2, ATF1, JUN
11	positive regulation of cell proliferation	GO:008284	INF	LRP5, KLF5, KIT, SFRP1, SFRP2, NBN
12	virus-host interaction	GO:019048	INF	PIK3R1, RELA, BUB1, RB1, RBL1, RBM15
13	negative regulation of apoptotic process	GO:043066	21.6	PIK3CG, PIM1, RELA, SFRP1, BRAF, VEGFA
14	nerve growth factor receptor signaling pathway	GO:048011	18.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, BRAF
15	induction of apoptosis	GO:006917	16.9	PDCD5, BOK, BNIP3, BIK, BCL2L11, BBC3
16	angiogenesis	GO:001525	16.7	PIK3CA, PIK3CG, KLF5, NCL, VEGFA, VEGFC
17	fibroblast growth factor receptor signaling pathway	GO:008543	16.7	PIK3CA, PIK3R1, BRAF, RAF1, CHUK, UBC
18	peptidyl-tyrosine phosphorylation	GO:018108	15.5	KIT, KDR, JAK1, JAK2, FLT1, FLT4
19	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	15.2	BOK, MYC, BCL2L10, BCL2L11, BBC3, BAD
20	Toll signaling pathway	GO:008063	14.8	RELA, CHUK, UBC, ATF1, JUN, CD14
21	toll-like receptor 4 signaling pathway	GO:034142	14.7	RELA, CHUK, UBC, ATF1, JUN, CD14
22	MyD88-dependent toll-like receptor signaling pathway	GO:002755	14.7	RELA, CHUK, UBC, ATF1, JUN, CDK1
23	induction of apoptosis by intracellular signals	GO:008629	14.6	BNIP3, MYC, BID, BCL2, BCL2L1, BCL2L11
24	toll-like receptor 2 signaling pathway	GO:034134	14.6	RELA, CHUK, UBC, ATF1, JUN, CDK1
25	toll-like receptor 3 signaling pathway	GO:034138	14.5	RELA, CHUK, UBC, ATF1, JUN, CD14
26	TRIF-dependent toll-like receptor signaling pathway	GO:035666	14.5	RELA, CHUK, UBC, ATF1, JUN, CD14
27	phosphatidylinositol-mediated signaling	GO:048015	14.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2A, PCNA
28	regulation of immune response	GO:050776	13.9	KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	13.9	KITLG, VTN, VEGFA, LIF, MTOR, JAK2
30	T cell costimulation	GO:031295	13.6	PIK3CA, PIK3R3, PIK3R2, PIK3R1, PDCD1, VAV1
31	platelet activation	GO:030168	INF	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
32	immune response	GO:006955	INF	NCR3, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR3DL1
33	positive regulation of cell migration	GO:030335	INF	VEGFA, KDR, LEF1, JAK2, CDH13, ITGAV
34	response to drug	GO:042493	INF	REN, SFRP1, SFRP2, NBN, VEGFC, MYC
35	cytokine-mediated signaling pathway	GO:019221	INF	PIN1, KLF6, NCAM1, RELA, KIT, LIFR
36	protein autophosphorylation	GO:046777	INF	PIM1, KIT, KDR, ULK3, CHEK2, MTOR
37	epidermal growth factor receptor signaling pathway	GO:007173	INF	PIK3CA, PIK3R1, PIK3C2A, RAF1, CLTC, CHUK
38	blood coagulation	GO:007596	INF	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
39	transforming growth factor beta receptor signaling pathway	GO:007179	INF	NCOR1, NCOR2, RBL1, MYC, PARP1, UBC
40	positive regulation of apoptotic process	GO:043065	INF	PIAS4, SFRP1, SFRP2, RARG, RARB, BID
41	Ras protein signal transduction	GO:007265	INF	RB1, RASGRP1, RAF1, RASGRP2, RASSF1, CDKN1A
42	anti-apoptosis	GO:006916	INF	PIM2, PIK3CA, RELA, SERPINB2, VNN1, NAIP
43	positive regulation of gene expression	GO:010628	INF	NCOA3, KIT, BRAF, VEGFA, VDR, LEF1
44	apoptotic process	GO:006915	INF	PIM1, PDCD1, PDCD5, SFRP5, PCNT, BUB1
45	negative regulation of cell proliferation	GO:008285	INF	PIM2, SFRP1, SFRP2, SFRP5, BTG1, VDR
46	interferon-gamma-mediated signaling pathway	GO:060333	INF	NCAM1, B2M, JAK1, JAK2, CD44, IRF1
47	insulin receptor signaling pathway	GO:008286	INF	PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3C2A
48	transcription, DNA-dependent	GO:006351	INF	ZNF296, PIAS4, KLF1, KLF2, KLF3, KLF6
49	cell cycle arrest	GO:007050	INF	RB1, NBN, MYC, RASSF1, MSH2, ATM
50	type I interferon-mediated signaling pathway	GO:060337	INF	JAK1, , IRF1, IRF2, IRF4, IRF8

Molecular functions related to myeloid leukemia according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	INF	, BTG1, BRCA1, RARA, RAC1, USF1
2	protein homodimerization activity	GO:042803	INF	KIT, VWF, SERPINF2, VEGFA, BNIP3, MZF1
3	sequence-specific DNA binding	GO:043565	INF	KLF2, VENTX, VDR, MYC, RARG, RARA
4	cytokine activity	GO:005125	16.2	KITLG, VEGFA, BMP6, LIF, CMTM5, FLT3LG
5	chromatin binding	GO:003682	16.1	NCOA2, NCOA3, RELA, LMO2, RAN, BCL6
6	double-stranded DNA binding	GO:003690	13.2	KLF6, MYC, RAD51, USF1, XRCC5, XRCC6
7	sequence-specific DNA binding transcription factor activity	GO:003700	INF	KLF1, KLF2, KLF3, KLF5, KLF6, RELA
8	growth factor activity	GO:008083	INF	KITLG, VEGFA, VEGFC, BMP6, LIF, CLEC11A
9	ATP binding	GO:005524	INF	PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3C2A, PIK3CG
10	protein kinase binding	GO:019901	INF	RELA, VIM, USF1, PARK2, BCL2L1, CHEK2
11	transcription factor binding	GO:008134	INF	PIM1, RELA, RB1, RBL1, NBN, NAB1
12	transcription regulatory region DNA binding	GO:044212	INF	KLF1, NCOR1, RELA, BRCA1, MZF1, BCOR
13	protein binding	GO:005515	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIR
14	protein tyrosine kinase activity	GO:004713	INF	KIT, KDR, BCR, JAK1, JAK2, FGFR1
15	protein heterodimerization activity	GO:046982	INF	BRAF, VEGFA, BOK, BNIP3, MYC, BMP6
16	protein kinase activity	GO:004672	INF	PIK3CG, BUB1, BRAF, RAF1, CHUK, AURKA