MCID: MYL006
MIFTS: 64

Myeloid Leukemia malady

Cancer category

Summaries for Myeloid Leukemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards: Myeloid Leukemia, also known as other myeloid leukemia, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The compounds retinoic acid and serine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and growth/size.

Aliases & Classifications for Myeloid Leukemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

myeloid leukemia 8 43 45 61
other myeloid leukemia 8 61
leukemia, myeloid 43 22
unspecified myeloid leukemia without mention of remission 8
myeloid leukemia, nos, without mention of remission 8
other myeloid leukemia without mention of remission 8
unspecified myeloid leukemia in remission 8
other myeloid leukemia in remission 8
myeloid leukemia, no icd-o subtype 8
myelogenous leukemia in remission 8
myeloid granulocytic leukemia 8
myeloid leukemia in remission 8
other myeloid leukemia nos 8
myeloid leukemia, disease 8
non-lymphocytic leukemia 8
leukemia myelogenous 8
myeloid leukemia nos 8
myeloid leukaemia 8
myeloid leukemias 8


External Ids:

Disease Ontology8 DOID:8692
ICD9CM27 205, 205.9
NCIt40 C3172
ICD1025 C92, C92.7

Related Diseases for Myeloid Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 381)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.6RUNX1, RUNX1T1, NPM1, CREBBP, FLT3, MLF1
2acute myeloid leukemia32.6RUNX1, NPM1, PICALM, FLT3, MLF1
3chronic myeloid leukemia32.3RUNX1, PTPN11, KMT2A, ABL1, CBFB, FLT3
4acute myeloid leukemia, adult31.6NPM1, PTPN11, KMT2A, RUNX1, FLT3
5myelodysplastic syndromes31.4FLT3, CREBBP, NPM1, RUNX1, MLF1, CBFB
6myeloid sarcoma31.2FLT3, KMT2A
7acute promyelocytic leukemia31.1FLT3, KMT2A, NPM1, CREBBP, RUNX1, RUNX1T1
8wilms tumor31.1KMT2A, ABL1, FLT3, CREBBP
9acute myelomonocytic leukemia31.0CREBBP, KMT2A, CBFB, RUNX1
10acute monocytic leukemia30.9CREBBP, KMT2A
11chronic myelomonocytic leukemia30.9RUNX1, FLT3, PTPN11
12myeloproliferative disorder30.8ABL1, RUNX1, FLT3, KMT2A, PTPN11
13acute lymphocytic leukemia30.8CREBBP, PTPN11, KMT2A, ABL1, CBFB, FLT3
14thrombocytosis30.7LIF, FLT3
15polycythemia vera30.6FLT3
16juvenile myelomonocytic leukemia30.4FLT3, PTPN11, RUNX1
17gastrointestinal stromal tumor30.4FLT3, MYH11, ABL1
18down syndrome30.4ERG, RUNX1, FLT3
19colorectal cancer30.3CREBBP, RUNX3
20adenocarcinoma30.2PIK3CG, CREBBP, LIF, RUNX3, MYH11, KMT2A
21megakaryocytic leukemia30.2RUNX1, KMT2A
22thyroid cancer30.0FLT3, ABL1
23acute lymphoblastic leukemia, childhood30.0ABL1, FLT3, RUNX1, KMT2A, PTPN11
24cleidocranial dysplasia30.0RUNX1, CBFB, RUNX2, RUNX3
25t-cell leukemia11.3
26acute t cell leukemia11.2
27leukemia, t-cell, chronic11.0
28acute myeloid leukemia, childhood10.9
29leukemia, b-cell, chronic10.9
30core binding factor acute myeloid leukemia10.9
31leukemia, acute myeloid, therapy-related10.8
32lymphoid leukemia10.8
33n syndrome10.8
34hematopoietic stem cell transplantation10.7
35philadelphia-negative chronic myeloid leukemia10.7
36mastocytosis10.6
37systemic mastocytosis10.6
38leukemia, acute myeloid, somatic10.6
39subacute myeloid leukemia10.5
40refractory anemia10.5
41graft versus host disease10.5
42natural killer cell leukemia10.5
43mast-cell leukemia10.5
44familial acute myeloid leukemia with mutated cebpa10.5
45plasma cell leukemia10.5
46diphtheria10.5
47essential thrombocythemia10.5
48tetraploidy10.5
49aspergillosis10.5
50diabetes insipidus10.5

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Clinical Features for Myeloid Leukemia

Drugs & Therapeutics for Myeloid Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Search CenterWatch for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

Sources:
22GTR
See all sources

Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia22

Anatomical Context for Myeloid Leukemia

Animal Models for Myeloid Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Myeloid Leukemia:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076814.1PTPN11, KMT2A, ABL1, MYH11, LIF, ERG
2MP:000537813.9PICALM, PTPN11, KMT2A, ABL1, MYH11, CBFB
3MP:000538513.5PTPN11, KMT2A, ABL1, MYH11, LIF, CBFB
4MP:000539713.5ERG, PTPN11, KMT2A, ABL1, RUNX3, RUNX2
5MP:000538713.5FLT3, LIF, CBFB, ABL1, KMT2A, PTPN11
6MP:000538413.4ERG, RUNX3, PTPN11, KMT2A, ABL1, CBFB
7MP:000537613.4MYH11, ABL1, KMT2A, PTPN11, CBFB, LIF
8MP:000538112.7RUNX1T1, MRVI1, CREBBP, LIF, CBFB, MYH11
9MP:000537012.4PTPN11, RUNX2, RUNX1, CBFB, NPM1, PICALM
10MP:000536912.3MRVI1, RUNX3, ABL1, MYH11, LIF, PIK3CG
11MP:001077112.3RUNX3, RUNX1, NPM1, PIK3CG, LIF, MYH11
12MP:000363112.3KMT2A, LIF, CBFB, CREBBP, ABL1, NPM1
13MP:000538812.0PTPN11, ABL1, LIF, CREBBP, CBFB, RUNX2
14MP:000539011.8RUNX3, CREBBP, LIF, CBFB, PIK3CG, KMT2A
15MP:000200611.8CBFB, PTPN11, KMT2A, FLT3, CREBBP, NPM1
16MP:000301211.6RUNX2, RUNX3, KMT2A, PTPN11, CBFB, RUNX1
17MP:000538211.3RUNX2, CREBBP, CBFB, ABL1, KMT2A, PTPN11
18MP:000539111.0LIF, NPM1, RUNX2
19MP:000538010.8KMT2A

Publications for Myeloid Leukemia

Sources:
51PubMed
See all sources

Articles related to Myeloid Leukemia:

(show top 50)    (show all 4923)
idTitleAuthorsYear
1
Prediction of adverse events during Intensive Induction chemotherapy for acute myeloid leukemia or high-grade myelodysplastic syndromes. (24382796)
2014
2
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. (24415537)
2014
3
Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation? (24319183)
2013
4
Management options for refractory chronic myeloid leukemia: considerations for the elderly. (23615798)
2013
5
Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia. (23866735)
2013
6
Notch2 inhibits proliferation of chronic myeloid leukemia cells. (23599800)
2013
7
SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. (23443343)
2013
8
Nonhematopoietic cells represent a more rational target of inA vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors. (23747997)
2013
9
Activity of the hypoxia-activated prodrug, TH-302, in preclinical human acute myeloid leukemia models. (24088735)
2013
10
Gingival enlargement as an early diagnostic indicator in therapy-related acute myeloid leukemia: A rare case report and review of literature. (23869136)
2013
11
The PERK-eIF2I+ phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells. (23095523)
2012
12
The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia. (22995644)
2012
13
Chronic graft versus host disease with small bowel obstruction after unrelated hematopoietic stem cell transplantation in a patient with acute myeloid leukemia. (22783362)
2012
14
MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. (22493297)
2012
15
Diabetes insipidus as an atypical presentation of acute myeloid leukemia. (22424594)
2012
16
Relationships between the gene polymorphisms of drug metabolizing enzymes and the outcome of the first induction chemotherapy in patients with de novo acute myeloid leukemia]. (21518482)
2011
17
Detection of nucleophosmin and FMS-like tyrosine kinase-3 gene mutations in acute myeloid leukemia. (21245599)
2011
18
The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0. (20111912)
2010
19
Minimal residual disease diagnostics in patients with acute myeloid leukemia in the post-transplant period: comparison of peripheral blood and bone marrow analysis. (20849383)
2010
20
Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia: t(8;21) and inv(16) represent different clinical outcomes. (19126873)
2009
21
Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations. (19357705)
2009
22
A clinical trial for homoharringtonine and low-dose cytosine arabinoside combined with G-CSF or GM-CSF to treat the relapsed or refractory acute myeloid leukemia (AML), geriatric AML and advanced myelodysplastic syndromes]. (19292062)
2009
23
Trisomy of chromosome 8 in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of BCR-ABL tyrosine kinases]. (19708570)
2009
24
Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice. (18367491)
2008
25
Evaluation of beta-catenin activating mutations in chronic myeloid leukemia. (17977597)
2008
26
High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. (18272813)
2008
27
Myeloid leukemias express a broad spectrum of VEGF receptors including neuropilin-1 (NRP-1) and NRP-2. (17917967)
2007
28
Epigenetic regulation of brain expressed X-linked-2, a marker for acute myeloid leukemia with mixed lineage leukemia rearrangements. (17251904)
2007
29
Targeting receptor tyrosine kinase signaling in acute myeloid leukemia. (17658267)
2007
30
The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia. (17360938)
2007
31
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation. (16982329)
2006
32
Assessment of bone marrow mesenchymal stem cell biological characteristics and support hemotopoiesis function in patients with chronic myeloid leukemia. (16448696)
2006
33
Activation of Raf1 and the ERK pathway in response to l-ascorbic acid in acute myeloid leukemia cells. (15451031)
2005
34
Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. (12829595)
2003
35
Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa. (12697869)
2003
36
SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. (12649163)
2003
37
Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23. (11840285)
2002
38
Polymorphism analysis of CYP3A5 in myeloid leukemia. (11836601)
2002
39
Peripheral blood leucocytes ornithine decarboxylase activity in chronic myeloid leukemia patients: prognostic and therapeutic implications. (11839377)
2002
40
Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck. (10849448)
2000
41
Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan. (10049058)
1999
42
Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process. (9581849)
1998
43
Value of molecular monitoring during the treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B study. (8996121)
1997
44
Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. (8630412)
1996
45
Relapsing acute myeloid leukemia manifesting as hypopyon uveitis. (7872398)
1995
46
Acute myeloid leukemia M4 with bone marrow eosinophilia (M4Eo) and inv(16)(p13q22) exhibits a specific immunophenotype with CD2 expression. (8098967)
1993
47
Correlation between serum level of soluble L-selectin and leukocyte count in chronic myeloid and lymphocytic leukemia and during bone marrow transplantation. (7690331)
1993
48
Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis. (1540262)
1992
49
Human recombinant stem cell factor stimulates in vitro proliferation of acute myeloid leukemia cells and expands the clonogenic cell pool. (1378162)
1992
50
In vitro differentiation of leukemic cells to eosinophils in the presence of interleukin-5 in two cases of acute myeloid leukemia with the translocation (8;21)(q22;q22). (1688504)
1990

Genetic Variations for Myeloid Leukemia

Expression for genes affiliated with Myeloid Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myeloid Leukemia

Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Compounds for genes affiliated with Myeloid Leukemia

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2414.0RUNX2, RUNX3, RUNX1, NPM1, PIK3CG, CREBBP
2serine4513.0RUNX3, RUNX2, RUNX1, RUNX1T1, PIK3CG, CREBBP
3vegf4512.8LIF, PTPN11, FLT3, ABL1, CREBBP, PIK3CG
4tyrosine4512.7RUNX1, RUNX2, ABL1, LIF, FLT3, CREBBP
5oligonucleotide4512.6ABL1, RUNX3, RUNX2, RUNX1, RUNX1T1, FLT3
6threonine4512.6RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3, ABL1
7phosphatidylinositol4512.4MYH11, LIF, FLT3, ABL1, PTPN11, PIK3CG
8zinc45 2413.1RUNX1, KMT2A, ABL1, CREBBP, NPM1, RUNX1T1
9atp45 2913.1PTPN11, NPM1, CREBBP, KMT2A, ABL1, LIF
10etoposide45 50 60 1115.0PIK3CG, FLT3, KMT2A, PTPN11, RUNX1, CREBBP
11doxorubicin45 50 1114.0CREBBP, RUNX1, NPM1, FLT3, PIK3CG, KMT2A
12proline4511.9PTPN11, KMT2A, ABL1, CREBBP, RUNX1T1, RUNX1
13imatinib45 50 1113.8PTPN11, RUNX1, PIK3CG, FLT3, ABL1
14herbimycin a45 6012.5FLT3, ABL1, PTPN11, PIK3CG
15phosphotyrosine4511.5PIK3CG, ABL1, PTPN11, FLT3
16sb 20358045 6012.4LIF, PIK3CG, PTPN11, RUNX2
17roscovitine4511.3CREBBP, PIK3CG, RUNX2
18rapamycin4511.3FLT3, NPM1, PIK3CG, PTPN11
19phenylephrine45 29 11 2414.3LIF, PIK3CG, CREBBP
20actinomycin d4511.2PIK3CG, KMT2A, NPM1, LIF
21paclitaxel45 50 1113.2NPM1, LIF, PIK3CG
22gp 1304511.2PTPN11, FLT3, LIF
23pd 98,0594511.1LIF, RUNX2, CREBBP, PIK3CG
24af 104511.1PICALM, KMT2A
25cytarabine45 50 1113.1FLT3, LIF, ABL1
26estrogen4511.0KMT2A
27ag-12964511.0PIK3CG, FLT3
28ly2940024510.9RUNX2, MYH11, PTPN11, PIK3CG

GO Terms for genes affiliated with Myeloid Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1RUNX1, RUNX3, RUNX2, NPM1, PICALM, CREBBP
2cytoplasmGO:00573712.5MLF2, MLF1, CREBBP, RUNX2, NPM1, PIK3CG
3nuclear chromatinGO:00079011.1RUNX3, RUNX2, CREBBP

Biological processes related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589311.6PICALM, CREBBP, KMT2A, RUNX1, RUNX2
2myeloid progenitor cell differentiationGO:00231811.3MLF1, FLT3, RUNX1
3cell maturationGO:04846911.3CBFB, RUNX2, RUNX3
4hemopoiesisGO:03009711.3FLT3, PICALM, RUNX1
5axon guidanceGO:00741111.2ABL1, RUNX3, MYH11, PTPN11
6peripheral nervous system neuron developmentGO:04893511.0RUNX1, RUNX3
7regulation of cell adhesion mediated by integrinGO:03362811.0PTPN11, PIK3CG
8protein complex assemblyGO:00646111.0KMT2A, CREBBP, PICALM
9definitive hemopoiesisGO:06021610.9CBFB, RUNX1
10myeloid cell differentiationGO:03009910.9CBFB, RUNX1
11regulation of endocytosisGO:03010010.6PICALM, ABL1

Molecular functions related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.7PIK3CG, CREBBP, FLT3, MLF1, CBFB, MYH11
2sequence-specific DNA binding transcription factor activityGO:00370011.9ERG, RUNX3, KMT2A, CBFB, CREBBP, RUNX1T1
3ATP bindingGO:00552411.5RUNX3, RUNX2, RUNX1, PIK3CG, FLT3, MYH11
4protein homodimerization activityGO:04280311.4KMT2A, FLT3, NPM1, RUNX1T1, RUNX1

Products for genes affiliated with Myeloid Leukemia

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Myeloid Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet