MCID: MYL006
MIFTS: 72

Myeloid Leukemia malady

Cancer diseases, Immune diseases categories

Summaries for Myeloid Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards: Myeloid Leukemia, also known as other myeloid leukemia, is related to leukemia and acute leukemia. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Transcriptional misregulation in cancer and Pathways in cancer. The compounds retinoic acid and serine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are mortality/aging and growth/size.

Aliases & Classifications for Myeloid Leukemia

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

myeloid leukemia 8 42 44 60
other myeloid leukemia 8 60
leukemia, myeloid 42 22
unspecified myeloid leukemia without mention of remission 8
myeloid leukemia, nos, without mention of remission 8
other myeloid leukemia without mention of remission 8
unspecified myeloid leukemia in remission 8
other myeloid leukemia in remission 8
myeloid leukemia, no icd-o subtype 8
myelogenous leukemia in remission 8
myeloid granulocytic leukemia 8
myeloid leukemia in remission 8
other myeloid leukemia nos 8
myeloid leukemia, disease 8
non-lymphocytic leukemia 8
leukemia myelogenous 8
myeloid leukemia nos 8
myeloid leukaemia 8
myeloid leukemias 8


External Ids:

Disease Ontology8 DOID:8692
ICD9CM27 205, 205.9
NCIt39 C3172
ICD1025 C92, C92.7

Related Diseases for Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
myeloid leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 394)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.7ERG, PICALM, PIK3CG, NPM1, RUNX1T1, RUNX1
2acute leukemia32.6NPM1, RUNX1T1, RUNX1, PTPN11, KMT2A, ABL1
3acute myeloid leukemia32.5RUNX1, NPM1, PICALM, FLT3, MLF1
4chronic myeloid leukemia32.3RUNX1, PIK3CG, CREBBP, FLT3, CBFB, ABL1
5myeloid sarcoma31.2KMT2A, FLT3
6sarcoma31.2RUNX1, PIK3CG
7monocytic leukemia31.1KMT2A, LIF, RUNX1
8acute monocytic leukemia31.0KMT2A, CREBBP
9acute lymphocytic leukemia30.9RUNX1, PICALM, CREBBP, FLT3, CBFB, ABL1
10breast cancer30.8RUNX3, RUNX2, RUNX1, NPM1, PIK3CG, CREBBP
11down syndrome30.8RUNX1, FLT3, ERG
12myelofibrosis30.7LIF
13thrombocytosis30.7LIF, FLT3
14acute myeloid leukemia, adult30.7RUNX1, NPM1, FLT3, KMT2A, PTPN11
15polycythemia vera30.6FLT3
16myeloma30.6PIK3CG, LIF
17megakaryocytic leukemia30.4RUNX1, KMT2A
18acute promyelocytic leukemia30.4RUNX1, RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3
19juvenile myelomonocytic leukemia30.4RUNX1, FLT3, PTPN11
20gastrointestinal stromal tumor30.4FLT3, MYH11, ABL1
21colorectal cancer30.3CREBBP, RUNX3
22melanoma30.3PIK3CG, FLT3, ABL1, PTPN11
23adenocarcinoma30.2RUNX3, PIK3CG, CREBBP, LIF, MYH11, KMT2A
24acute myelomonocytic leukemia30.2RUNX1, CREBBP, CBFB, KMT2A
25thyroid cancer30.0FLT3, ABL1
26colon cancer29.9RUNX3, RUNX1, PIK3CG, CREBBP, ABL1, PTPN11
27retinoblastoma29.9ABL1, CREBBP, PIK3CG, NPM1, RUNX1, RUNX2
28cleidocranial dysplasia29.9RUNX3, RUNX2, RUNX1, CBFB
29childhood leukemia10.9
30acute t cell leukemia10.8
31t-cell leukemia10.8
32lymphoid leukemia10.8
33lymphoblastic leukemia10.7
34chronic lymphocytic leukemia10.6
35neutropenia10.6
36familial acute myeloid leukemia with mutated cebpa10.6
37systemic mastocytosis10.5
38subacute myeloid leukemia10.5
39graft versus host disease10.5
40natural killer cell leukemia10.5
41mast-cell leukemia10.5
42diphtheria10.5
43cytogenetically normal acute myeloid leukemia10.5
44aspergillosis10.5
45polycythemia10.5
46core binding factor acute myeloid leukemia10.5
47diabetes insipidus10.4
48central nervous system leukemia10.4
49mediastinitis10.4
50invasive aspergillosis10.4

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Clinical Features for Myeloid Leukemia

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Drugs & Therapeutics for Myeloid Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Search CenterWatch for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

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22GTR
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Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia22

Anatomical Context for Myeloid Leukemia

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32MalaCards
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MalaCards organs/tissues related to Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, T cells, Monocytes, Endothelial, B cells, Breast, Nk cells, Lung, Testis, Testes, Colon, Skin, Kidney, Lymph node, Brain, Liver, Thyroid, Placenta, Tonsil, Pancreas, Small intestine, Smooth muscle, Pituitary, Eye, Spleen, Heart, B lymphoblasts

Animal Models for Myeloid Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloid Leukemia:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076814.1PIK3CG, NPM1, MRVI1, RUNX1T1, RUNX1, RUNX2
2MP:000537813.9ERG, RUNX3, RUNX2, RUNX1, RUNX1T1, NPM1
3MP:000538513.5PIK3CG, NPM1, MRVI1, RUNX1T1, RUNX1, RUNX2
4MP:000539713.5PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
5MP:000538713.5PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
6MP:000538413.4PICALM, PIK3CG, NPM1, RUNX1, RUNX2, RUNX3
7MP:000537613.4CREBBP, PICALM, PIK3CG, RUNX1, RUNX2, RUNX3
8MP:000538112.7RUNX3, RUNX2, RUNX1T1, MRVI1, CREBBP, LIF
9MP:000537012.4RUNX2, RUNX1, NPM1, PICALM, LIF, CBFB
10MP:000536912.3RUNX3, RUNX2, MRVI1, PIK3CG, CREBBP, LIF
11MP:001077112.3RUNX3, RUNX1, RUNX1T1, NPM1, PIK3CG, LIF
12MP:000363112.3RUNX1, NPM1, CREBBP, LIF, CBFB, ABL1
13MP:000538812.0RUNX3, RUNX2, CREBBP, LIF, CBFB, ABL1
14MP:000539011.8RUNX3, PIK3CG, CREBBP, LIF, CBFB, KMT2A
15MP:000200611.8RUNX1, NPM1, CREBBP, FLT3, CBFB, KMT2A
16MP:000301211.6PTPN11, KMT2A, CBFB, RUNX1, RUNX2, RUNX3
17MP:000538211.3RUNX2, CREBBP, CBFB, ABL1, KMT2A, PTPN11
18MP:000539111.0LIF, NPM1, RUNX2
19MP:000538010.8KMT2A

Publications for Myeloid Leukemia

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50PubMed
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Articles related to Myeloid Leukemia:

(show top 50)    (show all 4899)
idTitleAuthorsYear
1
Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children. (23677335)
2013
2
Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells. (22976128)
2013
3
The development of dasatinib as a treatment for chronic myeloid leukemia (CML): from initial studies to application in newly diagnosed patients. (23942795)
2013
4
Translocation t(1;11)(q21;q23): a new finding in congenital acute myeloid leukemia. (24001130)
2013
5
Deregulation of Mitochondrial ATPsyn-I^ in Acute Myeloid Leukemia Cells and with Increased Drug Resistance. (24391795)
2013
6
Role of anti-apoptotic pathways activated by BCR/ABL in the resistance of chronic myeloid leukemia cells to tyrosine kinase inhibitors. (24273759)
2013
7
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism. (24008673)
2013
8
Mees' lines in an acute myeloid leukemia patient. (24385821)
2013
9
FLAGIDA-lite is an effective regimen for patients between 70 and 80 years with acute myeloid leukemia or refractory anemia with excess blasts-2 and is feasible as outpatient treatment. (22015963)
2012
10
High-grade supraclavicular soft tissue sarcoma as secondary malignancy after successful treatment of acute myeloid leukemia: case report and literature review. (22281128)
2012
11
BCR-ABL mutations in chronic myeloid leukemia. (22054731)
2011
12
Hyperostosis - an unusual radiographic presentation of Myelodysplastic Syndrome transformed to Acute Myeloid Leukemia. (22470698)
2010
13
ML223: A Small Molecule Probe With In Vivo Activity Against Acute Myeloid Leukemia Subtype M4Eo (23658951)
2010
14
Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome. (19946261)
2010
15
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. (19808698)
2009
16
Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib. (19394750)
2009
17
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. (19878872)
2009
18
Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on patients with advanced myelodysplastic syndrome or acute myeloid leukemia transformed from myelodysplastic syndrome. (19672772)
2009
19
Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association. (19536888)
2009
20
Correlation of Fms-like tyrosine kinase 3 (FLT3) gene expression to FLT3/internal tandem duplication mutation in peripheral blood of acute myeloid leukemia.]. (19635202)
2009
21
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (18450602)
2008
22
Polymorphisms of RAD51(G135C) and XRCC3(C241T) genes and correlations thereof with prognosis and clinical outcomes of acute myeloid leukemia]. (18581889)
2008
23
Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. (18670883)
2008
24
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. (17972951)
2008
25
Vitamin D3 induces autophagy of human myeloid leukemia cells. (18628207)
2008
26
Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions. (18492691)
2008
27
Combination of SK-7041, one of novel histone deacetylase inhibitors, and STI571-induced synergistic apoptosis in chronic myeloid leukemia. (17762392)
2007
28
Bortezomib activity and in vitro interactions with anthracyclines and cytarabine in acute myeloid leukemia cells are independent of multidrug resistance mechanisms and p53 status. (17096161)
2007
29
Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. (17244680)
2007
30
Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia. (17928883)
2007
31
Breakthrough trichosporonosis in patients with acute myeloid leukemia receiving micafungin. (16840220)
2006
32
FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia. (16410383)
2006
33
L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms. (15313465)
2004
34
Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. (15339852)
2004
35
A novel cryptic translocation t(12;17)(p13;p12-p13) in a secondary acute myeloid leukemia results in a fusion of the ETV6 gene and the antisense strand of the PER1 gene. (12661008)
2003
36
Heterozygous PU.1 mutations are associated with acute myeloid leukemia. (12130514)
2002
37
Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition. (10777489)
2000
38
Chronic myeloid leukemia cells resistant to interferon-alpha lack STAT1 expression. (11920164)
2000
39
Immunity to WT1 in the animal model and in patients with acute myeloid leukemia. (10942395)
2000
40
P-glycoprotein and terminal transferase expression identify prognostic subsets within cytogenetic risk classes in acute myeloid leukemia. (10374859)
1999
41
Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia. (9885206)
1999
42
Functional expression of Fas (CD95) in acute myeloid leukemia cells in the context of CD34 and CD38 expression: possible correlation with sensitivity to chemotherapy. (9389707)
1997
43
Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the Children's Cancer Group. (9207434)
1997
44
Clinical significance of LEA-1 expression in adult acute myeloid leukemia. (8642844)
1996
45
Mixed-lineage acute myeloid leukemia associated with a suprasellar dysgerminoma. (7847266)
1995
46
HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. (7517211)
1994
47
Purification and characterization of a ubenimex (Bestatin)-sensitive aminopeptidase B-like enzyme from K562 human chronic myeloid leukemia cells. (8143849)
1994
48
Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase. (8398907)
1993
49
Therapy of chronic myeloid leukemia with interferon, alone or combined. Preliminary experience]. (1816638)
1991
50
Is trisomy 22 in acute myeloid leukemia a primary abnormality or only a secondary change associated with inversion 16? (2790767)
1989

Genetic Variations for Myeloid Leukemia

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Expression for genes affiliated with Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Leukemia

Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Myeloid Leukemia

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44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2414.0KMT2A, RUNX3, RUNX2, RUNX1, NPM1, PIK3CG
2serine4413.0RUNX3, RUNX2, RUNX1, RUNX1T1, PIK3CG, CREBBP
3vegf4412.8PIK3CG, RUNX1, RUNX2, RUNX3, CREBBP, FLT3
4tyrosine4412.7RUNX2, RUNX1, NPM1, PIK3CG, CREBBP, FLT3
5oligonucleotide4412.6RUNX3, RUNX2, RUNX1, RUNX1T1, FLT3, LIF
6threonine4412.6RUNX1, RUNX1T1, NPM1, PIK3CG, CREBBP, FLT3
7phosphatidylinositol4412.4RUNX2, PIK3CG, CREBBP, FLT3, LIF, MYH11
8zinc44 2413.1RUNX2, RUNX1, RUNX1T1, NPM1, CREBBP, ABL1
9atp44 2813.1NPM1, CREBBP, FLT3, LIF, ABL1, KMT2A
10etoposide44 49 59 1115.0RUNX1, PIK3CG, CREBBP, FLT3, KMT2A, PTPN11
11doxorubicin44 49 1114.0RUNX1, NPM1, PIK3CG, CREBBP, FLT3, KMT2A
12proline4411.9RUNX1, RUNX1T1, CREBBP, ABL1, KMT2A, PTPN11
13imatinib44 49 1113.8RUNX1, PIK3CG, FLT3, ABL1, PTPN11
14herbimycin a44 5912.5PIK3CG, FLT3, ABL1, PTPN11
15phosphotyrosine4411.5PTPN11, ABL1, FLT3, PIK3CG
16sb 20358044 5912.4RUNX2, PIK3CG, LIF, PTPN11
17roscovitine4411.3CREBBP, PIK3CG, RUNX2
18rapamycin4411.3NPM1, PIK3CG, FLT3, PTPN11
19phenylephrine44 28 11 2414.3PIK3CG, CREBBP, LIF
20actinomycin d4411.2KMT2A, LIF, PIK3CG, NPM1
21paclitaxel44 49 1113.2NPM1, PIK3CG, LIF
22gp 1304411.2PTPN11, LIF, FLT3
23pd 98,0594411.1RUNX2, PIK3CG, CREBBP, LIF
24af 104411.1KMT2A, PICALM
25cytarabine44 49 1113.1ABL1, LIF, FLT3
26estrogen4411.0KMT2A
27ag-12964411.0FLT3, PIK3CG
28ly2940024410.9RUNX2, PIK3CG, MYH11, PTPN11

GO Terms for genes affiliated with Myeloid Leukemia

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16Gene Ontology
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Cellular components related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.1ERG, RUNX3, RUNX2, RUNX1, NPM1, PICALM
2cytoplasmGO:00573712.5CREBBP, PIK3CG, NPM1, RUNX2, RUNX3, MLF1
3nuclear chromatinGO:00079011.1CREBBP, RUNX2, RUNX3

Biological processes related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589311.6KMT2A, CREBBP, PICALM, RUNX1, RUNX2
2myeloid progenitor cell differentiationGO:00231811.3MLF1, FLT3, RUNX1
3cell maturationGO:04846911.3CBFB, RUNX2, RUNX3
4hemopoiesisGO:03009711.3RUNX1, PICALM, FLT3
5axon guidanceGO:00741111.2RUNX3, MYH11, ABL1, PTPN11
6peripheral nervous system neuron developmentGO:04893511.0RUNX3, RUNX1
7regulation of cell adhesion mediated by integrinGO:03362811.0PTPN11, PIK3CG
8protein complex assemblyGO:00646111.0KMT2A, CREBBP, PICALM
9definitive hemopoiesisGO:06021610.9CBFB, RUNX1
10myeloid cell differentiationGO:03009910.9CBFB, RUNX1
11regulation of endocytosisGO:03010010.6ABL1, PICALM

Molecular functions related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.7ERG, RUNX3, RUNX2, RUNX1, RUNX1T1, MRVI1
2sequence-specific DNA binding transcription factor activityGO:00370011.9RUNX3, RUNX2, RUNX1, RUNX1T1, CREBBP, CBFB
3ATP bindingGO:00552411.5RUNX3, RUNX2, RUNX1, PIK3CG, FLT3, MYH11
4protein homodimerization activityGO:04280311.4KMT2A, FLT3, NPM1, RUNX1T1, RUNX1

Products for genes affiliated with Myeloid Leukemia

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Sources for Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet