MCID: MYL006
MIFTS: 75

Myeloid Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Immune diseases, Blood diseases categories
Download this MalaCard

Summaries for Myeloid Leukemia

About this section


Fully expand this MalaCard
Wikipedia:65 Myeloid leukemia is a type of leukemia affecting myeloid tissue. more...

MalaCards based summary: Myeloid Leukemia, also known as myelogenous leukemia in remission, is related to acute myeloid leukemia and chronic myeloid leukemia. An important gene associated with Myeloid Leukemia is PICALM (phosphatidylinositol binding clathrin assembly protein), and among its related pathways are Notch Signaling Pathways and TGF-beta Signaling Pathways. The compounds gp 130 and ponatinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid tissue, myeloid and bone, and related mouse phenotypes are tumorigenesis and craniofacial.

Disease Ontology:8 A leukemia that is located in myeloid tissue.

Aliases & Classifications for Myeloid Leukemia

About this section

Myeloid Leukemia, Aliases & Descriptions:

Name: Myeloid Leukemia 8 42 44 62
Myelogenous Leukemia in Remission 8 62
Myeloid Granulocytic Leukemia 8 62
Other Myeloid Leukemia 8 62
Leukemia, Myeloid 42 22
Myeloid Leukemias 8 62
Unspecified Myeloid Leukemia Without Mention of Remission 8
Myeloid Leukaemia, Nos, Without Mention of Remission 62
Other Myeloid Leukemia Without Mention of Remission 8
Myeloid Leukemia, Nos, Without Mention of Remission 8
Unspecified Myeloid Leukemia, in Remission 62
Unspecified Myeloid Leukemia in Remission 8
 
Other Myeloid Leukemia, in Remission 62
Other Myeloid Leukemia in Remission 8
Myeloid Leukemia, No Icd-O Subtype 8
Myeloid Leukaemia in Remission 62
Myeloid Leukemia in Remission 8
Other Myeloid Leukemia Nos 8
Non-Lymphocytic Leukaemia 62
Myeloid Leukemia, Disease 8
Non-Lymphocytic Leukemia 8
Myeloid Leukemia Nos 8
Leukemia Myelogenous 8
Myeloid Leukaemia 8


Classifications:



External Ids:

Disease Ontology8 DOID:8692
NCIt39 C3172
ICD9CM27 205.9, 205
ICD1025 C92, C92.7

Related Diseases for Myeloid Leukemia

About this section

Diseases in the Acute Myeloid Leukemia family:

Chronic Myeloid Leukemia Subacute Myeloid Leukemia
myeloid leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
'acute Myeloid Leukemia with T(9;11)(p22;q23)' 'acute Myeloid Leukemia with T(6;9)(p23;q34)'

Diseases related to Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 449)
idRelated DiseaseScoreTop Affiliating Genes
1acute myeloid leukemia33.2FLT3, RUNX1, MLF1, NPM1, CEBPA
2chronic myeloid leukemia32.7PTPN11, CREBBP, CBFB, RUNX1, ABL1, FLT3
3leukemia32.2RUNX1T1, LIF, RUNX1, RUNX3, RUNX2, ABL1
4myelodysplastic syndromes32.0ABL1, MLF1, PTPN11, CBFB, CREBBP, NPM1
5acute promyelocytic leukemia31.6RUNX1T1, FLT3, NPM1, CREBBP, RUNX1
6wilms tumor31.5FLT3, ABL1, CREBBP
7acute lymphoblastic leukemia31.4ABL1, PTPN11, RUNX1, CREBBP, CBFB, FLT3
8refractory anemia31.4FLT3, RUNX1
9acute myeloid leukemia, adult31.3RUNX1, PTPN11, NPM1, FLT3
10juvenile myelomonocytic leukemia31.2FLT3, PTPN11, RUNX1
11down syndrome31.2RUNX1, FLT3, ERG
12acute leukemia31.1NPM1, CREBBP, FLT3, CEBPA, CBFB, RUNX1T1
13monocytic leukemia31.1LIF, RUNX1
14gastrointestinal stromal tumor31.0FLT3, MYH11, ABL1
15acute myelomonocytic leukemia31.0RUNX1, CBFB, CREBBP
16pdgfrb-associated chronic eosinophilic leukemia31.0FLT3, RUNX1, PTPN11
17breast cancer30.8NPM1, CREBBP, LIF, MYH11, FLT3, CBFB
18cleidocranial dysplasia30.6RUNX2, RUNX1, CBFB, RUNX3
19precursor t-cell acute lymphoblastic leukemia30.6RUNX1, ABL1, FLT3, PICALM
20retinoblastoma30.4RUNX1, RUNX2, ABL1, CEBPA, CREBBP, NPM1
21hematologic cancer30.3NPM1, CREBBP, PTPN11, ABL1, RUNX1T1, RUNX1
22cytogenetically normal acute myeloid leukemia10.9
23core binding factor acute myeloid leukemia10.9
24sarcoma10.8
25myeloid sarcoma10.8
26hematopoietic stem cell transplantation10.8
27lymphoblastic leukemia10.7
28endotheliitis10.7
29chronic myelomonocytic leukemia10.7
30neutropenia10.6
31mastocytosis10.6
32systemic mastocytosis10.6
33familial acute myeloid leukemia with mutated cebpa10.6
34graft versus host disease10.6
35myelofibrosis10.6
36subacute myeloid leukemia10.6
37diphtheria10.5
38tetraploidy10.5
39acute myeloid leukemia with multilineage dysplasia10.5
40thrombocytosis10.5
41diabetes insipidus10.5
42aspergillosis10.5
43polycythemia10.5
44essential thrombocythemia10.5
45mn110.5
46philadelphia-negative chronic myeloid leukemia10.5
47mediastinitis10.5
48chronic lymphocytic leukemia10.5
49multiple myeloma10.5
50polycythemia vera10.5

Graphical network of the top 20 diseases related to Myeloid Leukemia:



Diseases related to myeloid leukemia

Symptoms for Myeloid Leukemia

About this section

Drugs & Therapeutics for Myeloid Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Myeloid Leukemia

Search NIH Clinical Center for Myeloid Leukemia

Genetic Tests for Myeloid Leukemia

About this section

Genetic tests related to Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Myeloid Leukemia22

Anatomical Context for Myeloid Leukemia

About this section

MalaCards organs/tissues related to Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, T cells, Monocytes, Endothelial, B cells, Breast, Neutrophil, Lung, Testis, Nk cells, Testes, Colon, Skin, Kidney, Lymph node, Brain, Liver, Thyroid, Eye, Spleen, Thymus, Heart, Smooth muscle, Small intestine, Pancreas, Placenta, Prostate, Tonsil, B lymphoblasts, Pituitary

FMA organs/tissues related to Myeloid Leukemia:

14
Myeloid tissue

Animal Models for Myeloid Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Myeloid Leukemia:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8CEBPA, NPM1, CBFB, CREBBP, FLT3, PTPN11
2MP:00053829.8ABL1, PTPN11, CREBBP, RUNX2, CBFB
3MP:00030129.7RUNX3, RUNX1, RUNX2, PTPN11, CBFB, CEBPA
4MP:00053759.7LIF, CREBBP, CEBPA, PTPN11, RUNX3
5MP:00053919.6CBFB, NPM1, CEBPA, LIF, PTPN11, ABL1
6MP:00053909.6CBFB, LIF, PTPN11, CREBBP, ABL1, RUNX1
7MP:00053709.5LIF, ABL1, RUNX2, CBFB, NPM1, CEBPA
8MP:00028739.5ERG, RUNX1, RUNX1T1, ABL1, PTPN11, CEBPA
9MP:00053809.4LIF, ABL1, NPM1, ERG, CREBBP, CBFB
10MP:00053889.4PTPN11, MYH11, LIF, CBFB, CREBBP, RUNX1
11MP:00053799.4CREBBP, CEBPA, LIF, PTPN11, RUNX2, RUNX3
12MP:00053699.4PTPN11, RUNX3, MYH11, CEBPA, RUNX2, ABL1
13MP:00107719.3RUNX1T1, RUNX2, PTPN11, NPM1, LIF, CBFB
14MP:00036319.2PTPN11, LIF, CBFB, CREBBP, ERG, NPM1
15MP:00053819.2LIF, MYH11, RUNX1T1, CREBBP, CEBPA, CBFB
16MP:00053769.2CBFB, CEBPA, CREBBP, RUNX2, LIF, MYH11
17MP:00053849.2NPM1, CREBBP, FLT3, RUNX3, RUNX1, RUNX2
18MP:00053979.0RUNX3, RUNX1, RUNX2, ABL1, PTPN11, FLT3
19MP:00053879.0NPM1, CREBBP, ERG, LIF, CBFB, ABL1
20MP:00053858.9CBFB, CREBBP, ERG, NPM1, LIF, MYH11
21MP:00053788.8PICALM, CEBPA, MYH11, LIF, CBFB, CREBBP
22MP:00107688.6RUNX1T1, RUNX1, RUNX3, PTPN11, RUNX2, ABL1

Publications for Myeloid Leukemia

About this section

Articles related to Myeloid Leukemia:

(show top 50)    (show all 4782)
idTitleAuthorsYear
1
Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. (24413389)
2014
2
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
3
Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. (24120526)
2014
4
Intraventricular hemorrhage in a patient with chronic myeloid leukemia and anterior communicating artery aneurysm. (23860156)
2013
5
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. (24035334)
2013
6
Treatment-, patient-, and disease-related factors and the emergence of adverse events with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia. (23553655)
2013
7
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. (23912609)
2013
8
Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as T-cell lymphoblastic lymphoma. (23486000)
2013
9
Mobilization of CD34(+)CD38(-) hematopoietic stem cells after priming in acute myeloid leukemia. (24179607)
2013
10
Dasatinib: a guide to its use in chronic myeloid leukemia in the EU. (23549840)
2013
11
Prognostic implication of BAALC gene expression in adult acute myeloid leukemia. (23865362)
2013
12
CAR T cells for acute myeloid leukemia: the LeY of the land. (24201214)
2013
13
Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells. (23878608)
2013
14
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. (22929312)
2012
15
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
16
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-I_B and underlies its chemo-resistance. (23077289)
2012
17
High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group. (22915059)
2012
18
Synergistic effect of 5-azacytidine and NF-I_B inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells. (24139415)
2012
19
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. (22490330)
2012
20
DNMT3A mutations are rare in childhood acute myeloid leukemia. (21685466)
2011
21
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (21951951)
2011
22
Summary of 615 patients of chronic myeloid leukemia in Shanghai from 2001 to 2006. (20199658)
2010
23
A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. (21156465)
2010
24
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. (19637342)
2009
25
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
26
Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (18768433)
2008
27
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. (18616510)
2008
28
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells. (18268283)
2008
29
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. (18401414)
2008
30
Analysis of NPM1 gene mutations in acute myeloid leukemia]. (17877154)
2007
31
Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. (17822317)
2007
32
Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. (17064874)
2007
33
Adenomatoid tumor of the testis in a patient on imatinib therapy for chronic myeloid leukemia. (16923575)
2006
34
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells. (15744347)
2005
35
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (15840695)
2005
36
Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. (15034867)
2004
37
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (12393722)
2003
38
Acute myeloid leukemia associated with necrotizing temporal arteritis. (12672210)
2003
39
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
40
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
41
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. (12145683)
2002
42
Drug therapy of chronic myeloid leukemia]. (11831070)
2002
43
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
44
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. (11568008)
2001
45
Cytokine expression of T cells in chronic myeloid leukemia. (11775253)
2000
46
Induction of gp130 and LIF by differentiation inducers in human myeloid leukemia K562 cells. (10613356)
1999
47
In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor. (9815618)
1997
48
Rearrangements and fusion gene of AML1 and MTG8 in acute myeloid leukemia M2b]. (7553157)
1995
49
Regulation of the expression of vimentin gene during the differentiation of mouse myeloid leukemia cells. (1970825)
1990
50
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984

Variations for Myeloid Leukemia

About this section

Expression for genes affiliated with Myeloid Leukemia

About this section
Expression patterns in normal tissues for genes affiliated with Myeloid Leukemia

Search GEO for disease gene expression data for Myeloid Leukemia.

Pathways for genes affiliated with Myeloid Leukemia

About this section

Compounds for genes affiliated with Myeloid Leukemia

About this section

Compounds related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1gp 1304410.3PTPN11, FLT3, LIF
2ponatinib50 1111.3FLT3, ABL1
3tgf beta14410.3LIF, FLT3, RUNX2
4agarose4410.3FLT3, LIF, NPM1
5cytarabine44 50 1112.3ABL1, FLT3, LIF
6etoposide44 50 61 1113.3CREBBP, FLT3, PTPN11, RUNX1
7imatinib44 50 1112.2FLT3, PTPN11, ABL1, RUNX1
8doxorubicin44 50 1112.2NPM1, CREBBP, FLT3, RUNX1
9herbimycin a44 6111.2FLT3, PTPN11, ABL1
10fatty acid4410.1RUNX2, LIF, CEBPA, CREBBP, NPM1
11proline4410.1RUNX1, RUNX1T1, ABL1, PTPN11, CREBBP
12thymidine44 2411.1RUNX2, PTPN11, FLT3, LIF
13nitric oxide44 24 1112.0RUNX2, PTPN11, MYH11, LIF, CREBBP
14zinc44 2411.0RUNX1, RUNX1T1, RUNX2, ABL1, CREBBP, NPM1
15cisplatin44 50 61 1112.9CREBBP, LIF, PTPN11, ABL1
16atp44 2810.9ABL1, PTPN11, FLT3, LIF, CREBBP, NPM1
17threonine449.9RUNX1, RUNX1T1, ABL1, PTPN11, FLT3, CREBBP
18phosphatidylinositol449.8RUNX2, ABL1, PTPN11, FLT3, MYH11, LIF
19estrogen449.8RUNX2, ABL1, MYH11, LIF, CEBPA, CREBBP
20glucose449.8CREBBP, CEBPA, LIF, PTPN11, RUNX2
21oligonucleotide449.8RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, PTPN11
22oxygen44 2410.7RUNX2, ABL1, PTPN11, LIF, CREBBP
23vegf449.6RUNX3, RUNX1, RUNX2, ABL1, PTPN11, FLT3
24serine449.6RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1, PTPN11
25tyrosine449.6RUNX1, RUNX2, ABL1, PTPN11, FLT3, LIF
26retinoic acid44 2410.5NPM1, RUNX3, RUNX1, RUNX2, ABL1, FLT3
27cysteine449.4ABL1, PTPN11, LIF, CREBBP, NPM1
28calcium44 50 24 1112.3RUNX2, ABL1, MRVI1, PTPN11, LIF, CREBBP

GO Terms for genes affiliated with Myeloid Leukemia

About this section

Cellular components related to Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00079010.1CREBBP, RUNX2, RUNX3
2nucleusGO:0056348.5NPM1, RUNX3, RUNX1, RUNX2, ABL1, PICALM
3cytoplasmGO:0057378.3MLF2, MLF1, ABL1, RUNX2, RUNX3, PTPN11

Biological processes related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system neuron developmentGO:04893510.4RUNX3, RUNX1
2myeloid cell differentiationGO:03009910.3RUNX1, CBFB, CEBPA
3myeloid progenitor cell differentiationGO:00231810.3FLT3, MLF1, RUNX1
4hemopoiesisGO:03009710.3FLT3, PICALM, RUNX1
5definitive hemopoiesisGO:06021610.3CBFB, RUNX1
6hair follicle morphogenesisGO:03106910.3RUNX1, RUNX3
7cell maturationGO:04846910.2CEBPA, CBFB, RUNX2, RUNX3
8regulation of endocytosisGO:03010010.1PICALM, ABL1
9axon guidanceGO:00741110.0MYH11, PTPN11, ABL1, RUNX3
10transcription from RNA polymerase II promoterGO:00636610.0RUNX3, LIF, CBFB, CEBPA, ERG
11negative regulation of cell proliferationGO:0082859.9FLT3, LIF, CEBPA, NPM1
12positive regulation of transcription, DNA-templatedGO:0458939.7RUNX1, RUNX2, PICALM, CREBBP

Molecular functions related to Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1repressing transcription factor bindingGO:07049110.3RUNX2, RUNX1
2protein homodimerization activityGO:0428039.9RUNX1, RUNX1T1, FLT3, CEBPA, NPM1
3protein domain specific bindingGO:0199049.7PTPN11, MLF1, RUNX2
4sequence-specific DNA binding transcription factor activityGO:0037009.7RUNX3, RUNX1, RUNX1T1, RUNX2, CBFB, CEBPA
5ATP bindingGO:0055249.6RUNX3, RUNX1, RUNX2, ABL1, FLT3, MYH11
6DNA bindingGO:0036779.5RUNX1, RUNX1T1, ABL1, MLF1, CBFB, CEBPA
7protein bindingGO:0055158.2NPM1, RUNX3, RUNX1, RUNX1T1, RUNX2, ABL1

Products for genes affiliated with Myeloid Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Myeloid Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet