MCID: MYL003
MIFTS: 54

Myeloid Sarcoma malady

Cancer diseases, Blood diseases categories

Summaries for Myeloid Sarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to sarcoma and acute myeloid leukemia. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Hematopoietic cell lineage. The compounds naphthol as-d chloroacetate and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Myeloid Sarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
granulocytic sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

myeloid sarcoma 8 42 10 48
granulocytic sarcoma 8 42 48 60
chloroma 8 42 48
extramedullary myeloid tumor 8 48
myeloid sarcoma without mention of remission 8
myeloid sarcoma in remission 8
myeloid sarcoma, morphology 8
myeloid sarcoma, disease 8
sarcoma granulocytic 44
myeloid sarcoma nos 8
monocytic sarcoma 42
erythroid sarcoma 42


External Ids:

Disease Ontology8 DOID:8683
ICD9CM27 205.3
MeSH34 D023981
MESH via Orphanet35 D023981
ICD10 via Orphanet26 C92.3
SNOMED-CT via Orphanet57 35287006, 94719007
ICD1025 C92.3

Related Diseases for Myeloid Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Clinical Features for Myeloid Sarcoma

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Drugs & Therapeutics for Myeloid Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Search CenterWatch for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Myeloid Sarcoma:

32
Myeloid, Bone, Bone marrow, Monocytes, Breast, Cervix, Liver, Uterus, Skin, Kidney, Heart, Appendix, Prostate, Lymph node, B cells, Testis, Tongue, Salivary gland, Thyroid, Lung, Colon, Small intestine, Brain, Spleen, Pineal

Animal Models for Myeloid Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloid Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6NPM1, FLT3, CD34, PTPRC, SPN
2MP:00053846.9FUT4, SPN, PTPRC, CD34, NCAM1, FLT3
3MP:00053976.8FUT4, NPM1, FLT3, MPO, CD33, CD34
4MP:00053876.7NPM1, FLT3, MPO, CD33, CD34, PTPRC

Publications for Myeloid Sarcoma

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50PubMed
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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Granulocytic sarcoma of the breast in acute myeloid leukemia: Two case reports. (24348837)
2014
2
Testicular Myeloid Sarcoma: An Unusual Presentation of Infant Acute Myeloid Leukemia. (24390442)
2014
3
Myeloid sarcoma developing in prexisting hydroxyurea-induced leg ulcer in a polycythemia vera patient. (24109489)
2013
4
Brachial Plexopathy due to Myeloid Sarcoma in a Patient With Acute Myeloid Leukemia After Allogenic Peripheral Blood Stem Cell Transplantation. (23705126)
2013
5
Misdiagnosed myeloid sarcoma of the vulva. (23489817)
2013
6
Chronic myelogenous leukemia presenting in blast phase with nodal, bilineal myeloid sarcoma and T-lymphoblastic lymphoma in a child. (23171293)
2013
7
Isolated central nervous system relapse presenting as myeloid sarcoma of acute myeloid leukemia after allogeneic peripheral blood stem cell transplantation. (22878457)
2013
8
Rare myeloid sarcoma/acute myeloid leukemia with adrenal mass after allogeneic mobilization peripheral blood stem cell transplantation. (24349834)
2013
9
Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma. (24354760)
2013
10
Myeloid sarcoma of the cheek and the maxillary sinus regions. (23557893)
2013
11
Orbital myeloid sarcoma presenting as massive proptosis. (23664602)
2013
12
Concomitant squamous cell carcinoma and myeloid sarcoma in pre-existing pterygium of the conjunctiva: diagnostic challenges. (22331932)
2012
13
Myeloid sarcoma and adenocarcinoma of the large bowel as collision tumors: a case report. (22648549)
2012
14
Clonal relationship between langerhans cell histiocytosis and myeloid sarcoma. (22382895)
2012
15
Frequent extramedullary recurrence of isolated myeloid sarcoma in the long-term follow-up. (22358067)
2012
16
Dysplastic megakaryocytes and eosinophilic precursors in the diagnosis of myeloid sarcoma on lymph node fine-needle aspiration cytology: a case series. (22555538)
2012
17
Myeloid sarcoma infiltration of aortic stent-graft causing chronic hemorrhage. (22891843)
2012
18
Gastric myeloid sarcoma--a report of two cases addressing diagnostic issues. (22234125)
2011
19
Post-tonsillectomy pulmonary complication in a patient with tonsillar myeloid sarcoma. (21234822)
2011
20
Pathology quiz case 2. Myeloid sarcoma (MS) of the submandibular gland. (21502486)
2011
21
A case of myeloid sarcoma with unusually extensive and rapidly progressive skin manifestations. (22065039)
2011
22
Myeloid sarcoma: current approach and therapeutic options. (23556098)
2011
23
Myeloid sarcoma of the vagina: a report of 2 cases. (20354424)
2010
24
Myeloid sarcoma in the nasal cavities that developed during the course of acute myelomonocytic leukemia. (21123976)
2010
25
Myeloid sarcoma involving the breast. (20698144)
2010
26
Acute myeloid leukaemia diagnosed by intra-oral myeloid sarcoma. A case report. (20512638)
2010
27
Spinal myeloid sarcoma in two non-leukemic patients. (21088356)
2010
28
Phlegmonous gastritis in a patient with myeloid sarcoma: a case report. (19644358)
2009
29
Myeloid sarcoma: extramedullary manifestation of myeloid disorders. (19687319)
2009
30
Temporal bone myeloid sarcoma. (20072695)
2009
31
Myeloid sarcoma of the small bowel associated with a CBFbeta/MYH11 fusion and inv(16)(p13q22): a case report. (19638550)
2009
32
Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma. (19387774)
2009
33
Myeloid sarcoma in essential thrombocythemia that transformed into acute myeloid leukemia. (19172381)
2009
34
Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. (18623376)
2008
35
Myeloid sarcoma in the central nervous system: case report and review of the literature. (18714643)
2008
36
Right atrial myeloid sarcoma causing superior vena cava syndrome. (18353162)
2008
37
Rapidly growing cobblestone-like nodules as a manifestation of myeloid sarcoma. (19002358)
2008
38
Acute promyelocytic leukaemia presenting with a myeloid sarcoma of the tongue. (18373707)
2008
39
Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. (16985182)
2007
40
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. (17170724)
2007
41
t(5;12)(q13;p13) in acute myeloid leukemia with preceding granulocytic sarcoma. (17854675)
2007
42
Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. (17405266)
2006
43
Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome: case report and review of literature. (16504290)
2006
44
Myeloid sarcoma of the maxillary bone. (16519776)
2006
45
Myeloid sarcoma of the appendix mimicking acute appendicitis. (15100117)
2004
46
Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. (14615822)
2003
47
Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. (10231412)
1999
48
Colonic adenomas with extramedullary myeloid tumor (granulocytic sarcoma). (10492089)
1999
49
Transformation of single myeloid precursor cells by the malignant histiocytosis sarcoma virus (MHSV): generation of growth-factor-independent myeloid colonies and permanent cell lines. (3366791)
1988
50
Cytologic diagnosis of myeloid sarcoma. (3857001)
1985

Genetic Variations for Myeloid Sarcoma

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Expression for genes affiliated with Myeloid Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Sarcoma

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Pathways for genes affiliated with Myeloid Sarcoma

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37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LYZ, CD34, MPO
29.3CD34, CD33, FLT3
38.9MPO, NCAM1, CD34, PTPRC
48.6SPN, PTPRC, CD34, NCAM1

Compounds for genes affiliated with Myeloid Sarcoma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Myeloid Sarcoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate4410.2PTPRC, MPO
2monochloroacetic acid4410.1PTPRC, MPO
3gemtuzumab ozogamicin44 1111.0CD33, FLT3
4fluorochrome449.7CD34, PTPRC
5fitc449.6PTPRC, CD34
6polylactosamine449.5FUT4, SPN
7daunorubicin44 49 1111.3NPM1, FLT3, MPO
8[alcl]449.3PTPRC, NPM1
9n-acetyllactosamine44 2410.2FUT4, PTPRC
10hematoxylin449.1NCAM1, MYH11, CD34, PTPRC
11fmlp449.0MPO, PTPRC, SPN, FUT4
12agarose448.9PTPRC, PGM1, FLT3, NPM1
13sialic acid448.9NCAM1, PTPRC, SPN, FUT4
14lactate448.8NPM1, FLT3, MPO, NCAM1
15polysaccharide448.8FUT4, SPN, PTPRC, NCAM1
16vegf448.7FLT3, MPO, NCAM1, MYH11, CD34
17progesterone44 59 28 11 2412.6NCAM1, MYH11, CD34, PTPRC
18threonine448.2NPM1, FLT3, NCAM1, PTPRC, SPN
19estrogen448.1NPM1, NCAM1, MYH11, CD34, PTPRC
20tyrosine447.5NPM1, FLT3, NCAM1, CD33, CD34, PTPRC
21paraffin447.5SPN, NPM1, MPO, NCAM1, MYH11, CD34
22retinoic acid44 247.9NPM1, FLT3, MPO, NCAM1, MYH11, CD34

GO Terms for genes affiliated with Myeloid Sarcoma

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16Gene Ontology
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Cellular components related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.5SPN, PTPRC, CD34, CD33, FLT3
2cell surfaceGO:0099868.3FLT3, NCAM1, SPN, FUT4
3external side of plasma membraneGO:0098978.2SPN, PTPRC, CD34, CD33, NCAM1

Products for genes affiliated with Myeloid Sarcoma

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Sources for Myeloid Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet