MCID: MYL003
MIFTS: 54

Myeloid Sarcoma malady

Cancer diseases, Blood diseases categories

Summaries for Myeloid Sarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to sarcoma and acute myeloid leukemia. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Hematopoietic cell lineage. The compounds naphthol as-d chloroacetate and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Myeloid Sarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
granulocytic sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

myeloid sarcoma 8 42 10 48
granulocytic sarcoma 8 42 48 60
chloroma 8 42 48
extramedullary myeloid tumor 8 48
myeloid sarcoma without mention of remission 8
myeloid sarcoma in remission 8
myeloid sarcoma, morphology 8
myeloid sarcoma, disease 8
sarcoma granulocytic 44
myeloid sarcoma nos 8
monocytic sarcoma 42
erythroid sarcoma 42


External Ids:

Disease Ontology8 DOID:8683
ICD9CM27 205.3
MeSH34 D023981
MESH via Orphanet35 D023981
ICD10 via Orphanet26 C92.3
SNOMED-CT via Orphanet57 35287006, 94719007
ICD1025 C92.3

Related Diseases for Myeloid Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Clinical Features for Myeloid Sarcoma

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Drugs & Therapeutics for Myeloid Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Search CenterWatch for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Myeloid Sarcoma:

32
Myeloid, Bone, Bone marrow, Monocytes, Breast, Cervix, Liver, Uterus, Skin, Kidney, Heart, Appendix, Prostate, Lymph node, B cells, Testis, Tongue, Salivary gland, Thyroid, Lung, Colon, Small intestine, Brain, Spleen, Pineal

Animal Models for Myeloid Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloid Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6NPM1, FLT3, CD34, PTPRC, SPN
2MP:00053846.9FUT4, SPN, PTPRC, CD34, NCAM1, FLT3
3MP:00053976.8FUT4, NPM1, FLT3, MPO, CD33, CD34
4MP:00053876.7NPM1, FLT3, MPO, CD33, CD34, PTPRC

Publications for Myeloid Sarcoma

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50PubMed
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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
One cancer destroys another: short report of a myeloid sarcoma causing ischaemic necrosis of an adenocarcinoma. (23922355)
2014
2
De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. (23095217)
2013
3
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
4
A "complicated" fracture: a Philadelphia chromosome-positive myeloid sarcoma of the bone. (23404583)
2013
5
Myeloid sarcoma with megakaryoblastic differentiation mimicking a sellar tumor. (24118374)
2013
6
Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion. (23314098)
2013
7
Gingival swelling and pleural effusion: non-leukemic myeloid sarcoma. (23336824)
2013
8
Conjunctival extrascleral extension of a myeloid sarcoma: a clinicopathological case report. (23629803)
2013
9
Is there a "gold" standard treatment for patients with isolated myeloid sarcoma? (23218987)
2013
10
Myeloid sarcoma of the head and neck region. (23530613)
2013
11
Thoracic t(9;22)-positive granulocytic sarcoma as initial presentation of chronic myeloid leukemia. (23763916)
2013
12
Clinicopathologic features and responses to radiotherapy of myeloid sarcoma. (24148102)
2013
13
Spontaneous remission in patients with acute myeloid leukemia with t(8;21) or cutaneous myeloid sarcoma: two case reports and a review of the literature. (23728561)
2013
14
Unusual coexistence of sinonasal myeloid sarcoma and acute fulminant invasive fungal sinusitis: a diagnostic dilemma. (23448530)
2013
15
Surgical resection for isolated myeloid sarcoma arising from a rib. (23098984)
2012
16
Erythroblastic sarcoma, an extremely rare variant of myeloid sarcoma. (22795354)
2012
17
Anterior chamber infiltrate in 3-month-old: rare presentation of myeloid sarcoma. (22744397)
2012
18
Isolated myeloid sarcoma without bone marrow involvement. (22398813)
2012
19
Primary myeloid sarcoma masquerading as an obstructing duodenal carcinoma. (23243527)
2012
20
Successful treatment of duodenal myeloid sarcoma with allogeneic bone marrow transplantation and additional radiotherapy. (22466836)
2012
21
Myeloid sarcoma: clinicopathologic, cytogenetic, and outcome analysis of 21 adult patients. (23213544)
2011
22
Butterfly lesion of the corpus callosum: an unusual case of extramedullary myeloid sarcoma (granulocytic sarcoma). (21467855)
2011
23
Unusual nodular bone marrow appearances in a case of myeloid sarcoma. (21554261)
2011
24
Myeloid sarcoma in a child with acute myeloblastic leukaemia. (21711997)
2011
25
Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia. (21556238)
2011
26
Secondary Leukemia in a non-Hodgkin's Lymphoma Patient Presenting as Myeloid Sarcoma of the Breast. (22937314)
2011
27
Utility of 18F-FDG PET/CT in identifying terminal ileal myeloid sarcoma in an asymptomatic patient. (21800353)
2011
28
Cardiac myeloid sarcoma: a case report and review of literature. (21941137)
2011
29
A case of myeloid sarcoma with correlation to JAK2V617F mutation, complicated by myelofibrosis and secondary acute myeloid leukemia. (22041374)
2011
30
Therapy-related myeloid sarcoma with an NPM1 mutation. (20858094)
2010
31
Late relapse of acute myeloblastic leukemia as myeloid sarcoma causing radiculopathy. (20933282)
2010
32
Therapy-related myelodysplastic syndrome presenting as fulminant heart failure secondary to myeloid sarcoma. (21544187)
2010
33
The Hammersmith Hospital hematopathology case of the month: myeloid sarcoma with Langerhans cell proliferation. (20536351)
2010
34
Myeloid Sarcoma of the Uterine Cervix as Presentation of Acute Myeloid Leukaemia after Treatment with Low-Dose Radioiodine for Thyroid Cancer: A Case Report and Review of the Literature. (20844570)
2009
35
Myeloid sarcoma of the prostate revealed by urinary retention: a case report. (21686890)
2009
36
Refractory de novo myeloid sarcoma: a case report and therapeutic strategy based on bone marrow minimal residual disease. (19513804)
2009
37
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
38
Myeloid sarcoma of the orbit. (19011308)
2008
39
Myeloid sarcoma presenting with bilateral proptosis and kidney infiltration. (17454781)
2007
40
Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study. (17974004)
2007
41
Myeloid sarcoma of the vulva as the presenting symptom in a patient with acute myeloid leukemia. (17499347)
2007
42
Sustained expression of nucleophosmin (NPM1) mutation at late relapse presenting as isolated myeloid sarcoma in a patient with acute myeloid leukemia. (17639390)
2007
43
Myeloid sarcoma of liver: an unusual cause of jaundice. Report of three cases and review of literature. (17355272)
2007
44
Myeloid sarcoma occurring concurrently with drug-induced gingival enlargement. (16579712)
2006
45
Myeloid sarcoma. (16220848)
2005
46
Subcutaneous myeloid sarcoma. (15655160)
2005
47
Myeloid sarcoma occurring in the maxillary gingiva: a case without leukemic manifestations. (15765782)
2005
48
Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. (15380340)
2004
49
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha. (14618084)
2003
50
Myeloid Sarcoma of the Superior Maxilla. Treatment by Surgery, Diathermy and Radium. (19987568)
1930

Genetic Variations for Myeloid Sarcoma

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Expression for genes affiliated with Myeloid Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Sarcoma

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Pathways for genes affiliated with Myeloid Sarcoma

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37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LYZ, CD34, MPO
29.3CD34, CD33, FLT3
38.9MPO, NCAM1, CD34, PTPRC
48.6SPN, PTPRC, CD34, NCAM1

Compounds for genes affiliated with Myeloid Sarcoma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Myeloid Sarcoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate4410.2PTPRC, MPO
2monochloroacetic acid4410.1PTPRC, MPO
3gemtuzumab ozogamicin44 1111.0CD33, FLT3
4fluorochrome449.7CD34, PTPRC
5fitc449.6PTPRC, CD34
6polylactosamine449.5FUT4, SPN
7daunorubicin44 49 1111.3NPM1, FLT3, MPO
8[alcl]449.3PTPRC, NPM1
9n-acetyllactosamine44 2410.2FUT4, PTPRC
10hematoxylin449.1NCAM1, MYH11, CD34, PTPRC
11fmlp449.0MPO, PTPRC, SPN, FUT4
12agarose448.9PTPRC, PGM1, FLT3, NPM1
13sialic acid448.9NCAM1, PTPRC, SPN, FUT4
14lactate448.8NPM1, FLT3, MPO, NCAM1
15polysaccharide448.8FUT4, SPN, PTPRC, NCAM1
16vegf448.7FLT3, MPO, NCAM1, MYH11, CD34
17progesterone44 59 28 11 2412.6NCAM1, MYH11, CD34, PTPRC
18threonine448.2NPM1, FLT3, NCAM1, PTPRC, SPN
19estrogen448.1NPM1, NCAM1, MYH11, CD34, PTPRC
20tyrosine447.5NPM1, FLT3, NCAM1, CD33, CD34, PTPRC
21paraffin447.5SPN, NPM1, MPO, NCAM1, MYH11, CD34
22retinoic acid44 247.9NPM1, FLT3, MPO, NCAM1, MYH11, CD34

GO Terms for genes affiliated with Myeloid Sarcoma

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16Gene Ontology
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Cellular components related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.5SPN, PTPRC, CD34, CD33, FLT3
2cell surfaceGO:0099868.3FLT3, NCAM1, SPN, FUT4
3external side of plasma membraneGO:0098978.2SPN, PTPRC, CD34, CD33, NCAM1

Products for genes affiliated with Myeloid Sarcoma

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Sources for Myeloid Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet