MCID: MYL003
MIFTS: 51

Myeloid Sarcoma

Categories: Rare diseases, Cancer diseases, Blood diseases, Immune diseases

Aliases & Classifications for Myeloid Sarcoma

MalaCards integrated aliases for Myeloid Sarcoma:

Name: Myeloid Sarcoma 12 49 55 14
Granulocytic Sarcoma 12 49 55 69
Extramedullary Myeloid Tumor 12 49 55
Chloroma 12 49 55
Sarcoma, Granulocytic 72
Sarcoma Granulocytic 51
Sarcoma, Myeloid 41

Characteristics:

Orphanet epidemiological data:

55
myeloid sarcoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:8683
ICD10 32 C92.3 C92.30
ICD9CM 34 205.3
MeSH 41 D023981
NCIt 46 C3520 C35815
Orphanet 55 ORPHA86850
MESH via Orphanet 42 D023981
UMLS via Orphanet 70 C0152276
ICD10 via Orphanet 33 C92.3
UMLS 69 C0152276

Summaries for Myeloid Sarcoma

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Acute myeloid leukemia .

MalaCards based summary : Myeloid Sarcoma, also known as granulocytic sarcoma, is related to myeloid leukemia and leukemia. An important gene associated with Myeloid Sarcoma is MPO (Myeloperoxidase), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Dexamethasone and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

Related Diseases for Myeloid Sarcoma

Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 myeloid leukemia 30.3 FLT3 KIT MPO NPM1
2 leukemia 29.8 FLT3 KIT KMT2A NPM1
3 myelofibrosis 29.8 FLT3 KIT MPO
4 leukemia, chronic myeloid 29.8 DNTT FLT3 KIT
5 blastic plasmacytoid dendritic cell 29.6 NCAM1 NPM1
6 acute biphenotypic leukemia 29.2 DNTT KMT2A MPO
7 chronic myelomonocytic leukemia 29.0 FLT3 KIT
8 lymphoblastic lymphoma 28.9 DNTT KMT2A MPO PTPRC
9 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 28.5 DNTT FLT3 KIT KMT2A MPO
10 myelodysplastic syndrome 28.2 ANPEP DNTT FLT3 KIT KMT2A NPM1
11 acute promyelocytic leukemia 27.9 ANPEP FLT3 MPO NCAM1 NPM1 PTPRC
12 acute leukemia 27.3 ANPEP DNTT FLT3 KIT KMT2A MPO
13 leukemia, acute myeloid 27.3 ANPEP DNTT FLT3 KIT KMT2A MPO
14 sarcoma 10.9
15 acute myeloid leukemia with minimal differentiation 10.4 FLT3 MPO
16 acute myeloblastic leukemia without maturation 10.4 FLT3 NPM1
17 chronic monocytic leukemia 10.3 MPO PTPRC
18 primary cutaneous anaplastic large cell lymphoma 10.3 NPM1 PTPRC
19 photokeratitis 10.3 DNTT PTPRC
20 epidural neoplasm 10.3 DNTT PTPRC
21 nodular lymphocyte predominant hodgkin lymphoma 10.3 PAX5 PTPRC
22 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.2 FLT3 KIT
23 hodgkin's lymphoma, lymphocytic depletion 10.2 PAX5 PTPRC
24 lymphatic system cancer 10.2 NPM1 PTPRC
25 tetrasomy 21 10.2 ANPEP DNTT
26 malignant leydig cell tumor 10.2 KIT PAX5
27 chronic eosinophilic leukemia 10.2 FLT3 KIT
28 extracutaneous mastocytoma 10.2 KIT PTPRC
29 diffuse cutaneous mastocytosis 10.2 KIT PTPRC
30 sarcomatoid squamous cell skin carcinoma 10.2 KIT PTPRC
31 conventional fibrosarcoma 10.1 KIT PTPRC
32 8p11 myeloproliferative syndrome 10.1 FLT3 KIT
33 testicular infarct 10.1 KIT PTPRC
34 gastric small cell carcinoma 10.1 NCAM1 PTPRC
35 cutaneous ganglioneuroma 10.1 KIT NCAM1
36 dendritic cell tumor 10.1 DNTT MPO PTPRC
37 core binding factor acute myeloid leukemia 10.1 FLT3 KIT
38 angiomyoma 10.1 KIT NCAM1
39 multiple cranial nerve palsy 10.1 MPO NCAM1
40 small cell neuroendocrine carcinoma 10.1 KIT NCAM1
41 plasma cell neoplasm 10.1 NCAM1 PTPRC
42 perineurioma 10.1 KIT NCAM1
43 rete testis neoplasm 10.1 KIT NCAM1
44 neurofibromatosis, type i 10.0 KIT NCAM1
45 lung lymphoma 10.0 NCAM1 PAX5
46 malignant skin fibrous histiocytoma 10.0 KIT NCAM1
47 acute myeloblastic leukemia with maturation 10.0 FLT3 KIT NPM1
48 anaplastic large cell lymphoma 10.0 NPM1 PAX5 PTPRC
49 large cell neuroendocrine carcinoma 10.0 KIT NCAM1
50 mast cell disease 10.0 KIT MPO

Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to Myeloid Sarcoma

Symptoms & Phenotypes for Myeloid Sarcoma

GenomeRNAi Phenotypes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

25 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.06 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.06 FLT3 KIT DNTT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.06 FLT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.06 FLT3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.06 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.06 FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.06 DNTT FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.06 MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.06 DNTT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.06 DNTT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.06 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.06 DNTT KIT MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.06 DNTT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.06 FLT3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.06 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.06 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.06 DNTT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.06 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.06 DNTT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.06 FLT3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.06 MPO
22 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.06 KIT
23 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.06 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.06 KIT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.06 MPO
26 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.06 MPO
27 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.06 MPO FLT3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.06 DNTT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.06 KIT
30 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.06 KIT
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.06 KIT

MGI Mouse Phenotypes related to Myeloid Sarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 ANPEP PAX5 DNTT FLT3 PTPRC KIT
2 cellular MP:0005384 9.87 NPM1 PAX5 FLT3 PTPRC KIT KMT2A
3 immune system MP:0005387 9.81 ANPEP PAX5 DNTT FLT3 PTPRC KIT
4 mortality/aging MP:0010768 9.56 NPM1 PAX5 FLT3 PTPRC KIT KMT2A
5 neoplasm MP:0002006 9.1 NPM1 PAX5 FLT3 PTPRC KIT KMT2A

Drugs & Therapeutics for Myeloid Sarcoma

Drugs for Myeloid Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Daunorubicin Approved Phase 3 20830-81-3 30323
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Idarubicin Approved Phase 3 58957-92-9 42890
5
Cytarabine Approved, Investigational Phase 3,Phase 2 147-94-4 6253
6
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Fludarabine Approved Phase 3,Phase 2 21679-14-1, 75607-67-9 30751
9
Busulfan Approved, Investigational Phase 3 55-98-1 2478
10
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 657311 5754
11
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
12
Thioguanine Approved Phase 3 154-42-7 2723601
13
Asparaginase Approved, Investigational Phase 3 9015-68-3
14
Aldesleukin Approved Phase 3,Phase 2 110942-02-4, 85898-30-2
15
Mitoxantrone Approved, Investigational Phase 3,Phase 2 65271-80-9 4212
16
Sorafenib Approved, Investigational Phase 3 284461-73-0 216239 406563
17
Bortezomib Approved, Investigational Phase 3 179324-69-7 387447 93860
18
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
20
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
21
Nicotinamide Approved, Investigational, Nutraceutical Phase 3 98-92-0 936
22
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
23 Dexamethasone acetate Phase 3 1177-87-3
24 Analgesics Phase 3,Phase 2
25 Alkylating Agents Phase 3,Phase 2
26 glucocorticoids Phase 3
27 Folic Acid Antagonists Phase 3
28 N-Methylaspartate Phase 3
29 Gastrointestinal Agents Phase 3
30 Topoisomerase Inhibitors Phase 3,Phase 2
31 Cortisol succinate Phase 3
32 Analgesics, Non-Narcotic Phase 3,Phase 2
33 Nucleic Acid Synthesis Inhibitors Phase 3
34 Vidarabine Phosphate Phase 3
35 Hormone Antagonists Phase 3
36 Dermatologic Agents Phase 3
37 Vitamin B Complex Phase 3
38 Hormones Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
40 Peripheral Nervous System Agents Phase 3,Phase 2
41 Hydrocortisone 17-butyrate 21-propionate Phase 3
42 Hydrocortisone acetate Phase 3
43 Hydrocortisone-17-butyrate Phase 3
44 Anti-Bacterial Agents Phase 3,Phase 2
45 Anti-HIV Agents Phase 3,Phase 2
46 Antiemetics Phase 3
47 Anti-Infective Agents Phase 3,Phase 2
48 Etoposide phosphate Phase 3
49 Immunosuppressive Agents Phase 3,Phase 2
50 Antimetabolites Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
2 Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT01371981 Phase 3 Asparaginase;Bortezomib;Cytarabine;Daunorubicin Hydrochloride;Etoposide;Mitoxantrone Hydrochloride;Sorafenib Tosylate
3 CIP-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Granulocytic Sarcoma Recruiting NCT02484391 Phase 2 6,8-Bis(benzylthio)octanoic Acid;Cytarabine;Mitoxantrone Hydrochloride
4 Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation Recruiting NCT02790515 Phase 2 Anti-thymocyte globulin (rabbit);Blinatumomab;Cyclophosphamide;Fludarabine;G-CSF;Melphalan;Mesna;Rituximab;Tacrolimus;Thiotepa;Sirolimus
5 Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia Recruiting NCT02658487 Phase 2 Cytarabine;Vosaroxin
6 Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior Transplantation Terminated NCT02259348 Phase 2 Cyclophosphamide;Fludarabine;Melphalan;Thiotepa;Rituximab
7 PET-CT in AML for Detection of Extramedullary AML Manifestations Completed NCT01278069
8 Central Nervous System (CNS) Involvement in Acute Myeloid Leukemia (AML) Not yet recruiting NCT03410407

Search NIH Clinical Center for Myeloid Sarcoma

Cochrane evidence based reviews: sarcoma, myeloid

Genetic Tests for Myeloid Sarcoma

Anatomical Context for Myeloid Sarcoma

MalaCards organs/tissues related to Myeloid Sarcoma:

38
Myeloid, Bone, Bone Marrow, T Cells, Breast, Kidney, Cervix

Publications for Myeloid Sarcoma

Articles related to Myeloid Sarcoma:

(show top 50) (show all 342)
# Title Authors Year
1
Role of Positron Emission Tomography Imaging in Myeloid Sarcoma. ( 29430131 )
2018
2
Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing. ( 28633614 )
2018
3
Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement. ( 29151502 )
2018
4
Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration. ( 29295844 )
2018
5
A Rare Cause of Paraplegia: Myeloid Sarcoma. ( 29393854 )
2018
6
Myeloid Sarcoma Presented as Generalized Lymphadenopathy: Mimicking Malignant Lymphoma. ( 29398826 )
2018
7
How Rare Is an Oral Presentation of Myeloid Sarcoma in the Infant? ( 28943463 )
2017
8
Myeloid sarcoma of the thyroid. ( 29236267 )
2017
9
Primary myeloid sarcoma of small bowel. ( 28596206 )
2017
10
Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: A report of four cases. ( 28927153 )
2017
11
Myeloid Sarcoma Presenting as Nasal and Orbital Mass: An Initial Manifestation of an Acute Myeloid Leukaemia. ( 28892915 )
2017
12
An unusual type of myeloid sarcoma localization following myelofibrosis: A case report and literature review. ( 28794969 )
2017
13
Use of magnetic resonance imaging for diagnosis and after treatment of patients with myeloid sarcoma of the brain. ( 29254273 )
2017
14
Cardiac Myeloid Sarcoma: Review of Literature. ( 28511492 )
2017
15
Myeloid sarcoma: A clinicopathological study with emphasis on diagnostic difficulties. ( 29237964 )
2017
16
Prostate Mass as a First Manifestation of Myeloid Sarcoma in a Patient With an Occult Acute Myeloid Leukemia-A Case Report. ( 28627396 )
2017
17
Isolated myeloid sarcoma of cervix: Aleukemic presentation. ( 29237986 )
2017
18
Myeloid sarcoma of the sigmoid colon: An unusual presentation of a rare condition. ( 28606757 )
2017
19
Multiple Nonleukemic Myeloid Sarcoma Associated Hemophagocytic Lymphohistiocytosis in an Adult. ( 29226650 )
2017
20
Isolated Intracranial Myeloid Sarcoma Occurring as Relapse in Acute Myeloid Leukemia. ( 28694637 )
2017
21
Myeloid sarcoma of the oral cavity: A case report and review of 89 cases from the literature. ( 29075423 )
2017
22
Myeloid sarcoma identified on liquid-based cervical cytology samples: A report of two cases. ( 28569009 )
2017
23
Isolated myeloid sarcoma as the first manifestation of acute myeloid leukemia: a case study. ( 29152275 )
2017
24
Cutaneous myeloid sarcoma associated with chronic myeloid leukemia. ( 29267445 )
2017
25
Intracranial Myeloid Sarcoma Metastasis Mimicking Acute Subdural Hematoma. ( 29201484 )
2017
26
Invasive Fungal Infection in Acute Myeloid Leukemia Associated with Myeloid Sarcoma of the Sinonasal Cavity: A Rare Case. ( 28607903 )
2017
27
Myeloid sarcoma causing airway obstruction. ( 28405080 )
2017
28
Clinical features and outcomes of extramedullary myeloid sarcoma in the United States: analysis using a national data set. ( 28841208 )
2017
29
Clinical characteristics, molecular profile and outcomes of myeloid sarcoma: a single institution experience over 13 years. ( 28574302 )
2017
30
Clinical characteristics and treatment outcomes of isolated myeloid sarcoma without bone marrow involvement: a single-institution experience. ( 29043233 )
2017
31
Extramedullary leukaemia presenting as cardiac myeloid sarcoma. ( 28513107 )
2017
32
Successful 5-azacytidine treatment of myeloid sarcoma and leukemia cutis associated with myelodysplastic syndrome: A case report and literature review. ( 28885352 )
2017
33
Myeloid Sarcoma in a Patient with Myelodysplastic Syndrome Associated with del(5q-): Case Report and Literature Review. ( 28801374 )
2017
34
Successful second allogeneic stem cell transplantation in a patient with T-lymphoblastic leukemia (T-ALL) relapsed as myeloid sarcoma. ( 28451803 )
2017
35
Extensive ulcerated lesions in a patient with cutaneous myeloid sarcoma responded to twice-daily fludarabine and cytarabine regimen. ( 28624256 )
2017
36
A myeloid sarcoma involving the small intestine, kidneys, mesentery, and mesenteric lymph nodes: A case report and literature review. ( 29049187 )
2017
37
T cell acute lymphoblastic lymphoma complicated with myeloid sarcoma in an adult: A case report. ( 29344261 )
2017
38
Hepatic myeloid sarcoma diagnosed at autopsy: A case report. ( 27773146 )
2016
39
Clinicopathological, Cytogenetic, and Prognostic Analysis of 131 Myeloid Sarcoma Patients. ( 27631510 )
2016
40
Clinicopathological features of myeloid sarcoma: Report of 39 cases and literature review. ( 27515547 )
2016
41
Myeloid sarcoma of the orbit without systemic recurrence of disease in an adult: A clinicopathological case report. ( 26905183 )
2016
42
Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature. ( 27313759 )
2016
43
Shoulder Myeloid Sarcoma: An Initial Presentation of CML Blast Crisis. ( 27408438 )
2016
44
Myeloid Sarcoma of the Hepatobiliary System: A Case Series and Review of the Literature. ( 27007946 )
2016
45
Myeloid Sarcoma in an Eyelid That Developed during Chemotherapy for Acute Myeloid Leukemia. ( 26889156 )
2016
46
Myeloid sarcoma of submandibular salivary gland. ( 27489709 )
2016
47
Isolated Uterine Myeloid Sarcoma Preceding the Diagnosis of Acute Myeloid Leukemia. ( 27376223 )
2016
48
Orbital myeloid sarcoma: Rare presentation of AML. ( 27074545 )
2016
49
Evidence for a role of decitabine in the treatment of myeloid sarcoma. ( 27817041 )
2016
50
Spontaneous remission of aleukemic cutaneous myeloid sarcoma followed by crisis of acute monoblastic leukemia. ( 26661142 )
2016

Variations for Myeloid Sarcoma

Expression for Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

Pathways for Myeloid Sarcoma

GO Terms for Myeloid Sarcoma

Cellular components related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 ANPEP KIT NCAM1 PTPRC

Biological processes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 9.32 KIT KMT2A
2 T cell differentiation GO:0030217 9.26 KIT PTPRC
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.16 FLT3 KIT
4 embryonic hemopoiesis GO:0035162 8.96 KIT KMT2A
5 myeloid progenitor cell differentiation GO:0002318 8.62 FLT3 KIT

Sources for Myeloid Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....