MCID: MYL003
MIFTS: 48

Myeloid Sarcoma malady

Rare diseases, Cancer diseases, Blood diseases categories

Aliases & Classifications for Myeloid Sarcoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 43Novoseek, 38NCIt, 33MeSH, 55SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Myeloid Sarcoma, Aliases & Descriptions:

Name: Myeloid Sarcoma 9 41 11 47
Granulocytic Sarcoma 9 41 47 60
Chloroma 9 41 47
Myeloid Sarcoma Without Mention of Remission 9 60
Myeloid Sarcoma in Remission 9 60
Extramedullary Myeloid Tumor 9 47
 
Myeloid Sarcoma, Morphology 9
Myeloid Sarcoma, Disease 9
Sarcoma Granulocytic 43
Myeloid Sarcoma Nos 9
Monocytic Sarcoma 41
Erythroid Sarcoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
granulocytic sarcoma:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:8683
MeSH33 D023981
ICD9CM27 205.3
Orphanet47 86850
ICD10 via Orphanet26 C92.3
MESH via Orphanet34 D023981
ICD1025 C92.3

Summaries for Myeloid Sarcoma

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Wikipedia:63 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards based summary: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to sarcoma and chronic myelomonocytic leukemia. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are HIF-1-alpha transcription factor network and C-MYB transcription factor network. The compounds gemtuzumab ozogamicin and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Related Diseases for Myeloid Sarcoma

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Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.5LYZ, PTPRC, CD34
2chronic myelomonocytic leukemia30.5FLT3, MPO
3histiocytosis30.4LYZ, PGM1
4lymphoblastic lymphoma30.4PTPRC, MPO
5myeloid leukemia30.2PTPRC, NPM1, CD33, CD34, MPO, FLT3
6peripheral t-cell lymphoma30.2PTPRC, NCAM1
7myelodysplastic syndrome29.6MPO, NPM1, FLT3, CD33, CD34, SPN
8leukemia29.4PTPRC, FUT4, MPO, SPN, FLT3, LYZ
9acute leukemia29.0NCAM1, PTPRC, MPO, CD34, NPM1, FLT3
10duodenitis10.3
11mediastinitis10.3
12hematopoietic stem cell transplantation10.3
13myelofibrosis10.3
14gingivitis10.3
15vaginitis10.3
16periodontal disease10.3MPO, LYZ
17skin disease10.3LYZ, MPO
18perineurioma10.3CD34
19leukemia, acute myeloid10.2FLT3, NPM1
20colon adenoma10.2
21adenoma10.2
22cervicitis10.2
23meningitis10.2
24appendicitis10.2
25radiculopathy10.2
26adenocarcinoma10.2
27intestinal obstruction10.2
28prostatitis10.2
29acute myelomonocytic leukemia10.2
30essential thrombocythemia10.2
31cork-handlers' disease10.2LYZ, MPO
32leukopenia10.1NCAM1, MPO
33bone marrow cancer10.1MPO, FLT3
34reticulosarcoma10.1NPM1, PTPRC
35hypersensitivity reaction type ii disease10.1NCAM1, LYZ, MPO
36hcl-v10.1PTPRC, FLT3
37malignant fibroxanthoma10.1LYZ, CD34
38embryonal rhabdomyosarcoma10.1NCAM1, PTPRC
39neuroendocrine tumor10.1PTPRC, NCAM1
40tonsillitis10.0
41cauda equina syndrome10.0
42adenoiditis10.0
43germinoma10.0
44angiosarcoma10.0
45hermaphroditism10.0
46mature teratoma10.0
47microsporidiosis10.0
48testicular cancer10.0
49ectopic pregnancy10.0
50hypereosinophilic syndrome10.0

Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Symptoms for Myeloid Sarcoma

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Drugs & Therapeutics for Myeloid Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

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MalaCards organs/tissues related to Myeloid Sarcoma:

31
Myeloid, Bone, Bone marrow, Monocytes, Breast, Liver, Cervix, Brain, Heart, Kidney, Skin, Uterus, Prostate, Appendix, Lymph node, Spleen, Spinal cord, Small intestine, Lung, Thyroid, Salivary gland, Testis, B cells, Tongue, Pineal

Animal Models for Myeloid Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Myeloid Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9SPN, PTPRC, FLT3, NPM1, CD34
2MP:00053847.4CD34, NPM1, NCAM1, FLT3, PTPRC, FUT4
3MP:00053976.8CD34, SPN, FUT4, PTPRC, MPO, FLT3
4MP:00053876.6SPN, FUT4, PTPRC, MPO, FLT3, NPM1

Publications for Myeloid Sarcoma

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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Aggressive Myeloid Sarcoma Causing Recurrent Spinal Cord Compression. (25888811)
2015
2
Primary vaginal myeloid sarcoma: a rare case report and review of the literature. (25685570)
2015
3
Myeloid sarcoma as the presenting symptom of chronic myelogenous leukemia blast crisis. (24982578)
2014
4
Myeloid sarcoma preceding an acute promyelocytic leukaemia with neuromeningeal infiltration. (23716188)
2014
5
Myeloid sarcoma: a rare case of an orbital mass mimicking orbital pseudotumor requiring neurosurgical intervention. (25478260)
2014
6
Oral myeloid sarcoma: two case reports. (25159834)
2014
7
De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. (23095217)
2013
8
Myeloid sarcoma developing in prexisting hydroxyurea-induced leg ulcer in a polycythemia vera patient. (24109489)
2013
9
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
10
Gingival myeloid sarcoma in myelodysplastic syndrome. (23288397)
2013
11
A "complicated" fracture: a Philadelphia chromosome-positive myeloid sarcoma of the bone. (23404583)
2013
12
Myeloid sarcoma with megakaryoblastic differentiation mimicking a sellar tumor. (24118374)
2013
13
Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion. (23314098)
2013
14
Surgical resection for isolated myeloid sarcoma arising from a rib. (23098984)
2012
15
Cutaneous myeloid sarcoma presenting as grey pigmented macules. (22278733)
2012
16
A case of inguinal sparganosis mimicking myeloid sarcoma. (23230335)
2012
17
Ocular myeloid sarcoma in a 10-year-old child. (22296819)
2012
18
Concomitant squamous cell carcinoma and myeloid sarcoma in pre-existing pterygium of the conjunctiva: diagnostic challenges. (22331932)
2012
19
Isolated recurrence of intracranial and temporal bone myeloid sarcoma--case report. (22198109)
2011
20
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation. (22185993)
2011
21
Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10A years. (21181316)
2011
22
Gastric myeloid sarcoma--a report of two cases addressing diagnostic issues. (22234125)
2011
23
Myeloid sarcoma: clinicopathologic, cytogenetic, and outcome analysis of 21 adult patients. (23213544)
2011
24
Myeloid sarcoma mimicking nasopharyngeal carcinoma. (21747080)
2011
25
Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. (21685467)
2011
26
Butterfly lesion of the corpus callosum: an unusual case of extramedullary myeloid sarcoma (granulocytic sarcoma). (21467855)
2011
27
Post-tonsillectomy pulmonary complication in a patient with tonsillar myeloid sarcoma. (21234822)
2011
28
Myeloid sarcoma of the vagina: a report of 2 cases. (20354424)
2010
29
Therapy-related myeloid sarcoma with an NPM1 mutation. (20858094)
2010
30
Late relapse of acute myeloblastic leukemia as myeloid sarcoma causing radiculopathy. (20933282)
2010
31
Myeloid sarcoma in the nasal cavities that developed during the course of acute myelomonocytic leukemia. (21123976)
2010
32
Myeloid sarcoma involving the breast. (20698144)
2010
33
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
34
Myeloid sarcoma of the breast mimicking hamartoma on sonography. (19023005)
2008
35
Life-threatening conjunctival presentation of myeloid sarcoma. (19128384)
2008
36
Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. (18623376)
2008
37
Myeloid sarcoma in the central nervous system: case report and review of the literature. (18714643)
2008
38
Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)
2007
39
Myeloid sarcoma presenting as an isolated nodule in a patient with acute myelogenous leukemia. (17668545)
2007
40
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. (17170724)
2007
41
Isolated myeloid sarcoma presenting in all four eyelids. (17667120)
2007
42
Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16). (16740041)
2006
43
Myeloid sarcoma of the extrahepatic bile ducts presenting as obstructive jaundice. (16948823)
2006
44
Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. (17405266)
2006
45
Acute myeloid leukemia with concurrent myeloid sarcoma treated with autologous bone marrow transplantation: two illustrative cases and a literature review. (16273593)
2005
46
Myeloid sarcoma involving the testis. (16191514)
2005
47
Genomic profiling of myeloid sarcoma by array comparative genomic hybridization. (16080198)
2005
48
Primary myeloid sarcoma of the testicle with t(15;17). (15721636)
2005
49
FLT3 mutations in myeloid sarcoma. (15352981)
2004
50
Primary myeloid sarcoma of the gynecologic tract: a report of two cases progressing to acute myeloid leukemia. (12533040)
2002

Variations for Myeloid Sarcoma

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Expression for genes affiliated with Myeloid Sarcoma

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Search GEO for disease gene expression data for Myeloid Sarcoma.

Pathways for genes affiliated with Myeloid Sarcoma

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Pathways related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPM1, PGM1
29.3MPO, LYZ, CD34
39.3CD34, CD33, FLT3
48.7CD34, NCAM1, MPO, PTPRC
58.4CD34, NCAM1, PTPRC, SPN

Compounds for genes affiliated with Myeloid Sarcoma

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Sources:
49PharmGKB, 43Novoseek, 12DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

(show all 29)
idCompoundScoreTop Affiliating Genes
1gemtuzumab ozogamicin49 43 1212.1CD33, FLT3
2monochloroacetic acid4310.1PTPRC, MPO
3naphthol as-d chloroacetate4310.1PTPRC, MPO
4[alcl]439.9PTPRC, NPM1
5fluorescein43 1210.9PTPRC, MPO
6mitoxantrone43 49 1211.8FLT3, MPO
7daunorubicin43 49 1211.8NPM1, FLT3, MPO
8fluorochrome439.8CD34, PTPRC
9fitc439.7CD34, PTPRC
10cytochalasin b439.6MPO, SPN
11n-acetyllactosamine43 2410.4PTPRC, FUT4
12polylactosamine439.3FUT4, SPN
13histamine43 28 2411.3NCAM1, MPO, PTPRC
14hematoxylin439.3PTPRC, NCAM1, CD34
15methylcellulose439.3CD34, FLT3
16lactate439.3MPO, FLT3, NCAM1, NPM1
17agarose439.3PTPRC, PGM1, FLT3, NPM1
1812-o-tetradecanoylphorbol 13-acetate439.2PTPRC, NCAM1, CD34
19doxorubicin43 49 1211.1FLT3, NCAM1, NPM1
20vegf439.0CD34, NCAM1, FLT3, MPO
21estrogen438.7PTPRC, NCAM1, NPM1, CD34
22fmlp438.7SPN, FUT4, PTPRC, MPO
23threonine438.5SPN, PTPRC, FLT3, NCAM1, NPM1
24sialic acid438.4NCAM1, PTPRC, FUT4, SPN
25polysaccharide438.4NCAM1, PTPRC, FUT4, SPN
26calcium43 49 24 1211.2SPN, PTPRC, MPO, NCAM1, NPM1, CD33
27paraffin438.1CD34, NPM1, NCAM1, MPO, PTPRC, SPN
28tyrosine437.7SPN, PTPRC, FLT3, NCAM1, NPM1, CD33
29retinoic acid43 248.4SPN, FUT4, MPO, FLT3, NCAM1, NPM1

GO Terms for genes affiliated with Myeloid Sarcoma

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Cellular components related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.4LYZ, PGM1, MPO, PTPRC, SPN
2external side of plasma membraneGO:00098978.1CD34, CD33, NCAM1, PTPRC, SPN
3cell surfaceGO:00099868.0SPN, FUT4, FLT3, NCAM1
4integral component of plasma membraneGO:00058877.9SPN, PTPRC, FLT3, CD33, CD34

Biological processes related to Myeloid Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemopoiesisGO:00300979.6CD34, FLT3
2positive regulation of T cell proliferationGO:00421029.4PTPRC, SPN
3negative regulation of cell proliferationGO:00082859.2CD33, NPM1, FLT3
4signal transductionGO:00071658.6SPN, NPM1, CD33, CD34

Products for genes affiliated with Myeloid Sarcoma

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Sources for Myeloid Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet