MCID: MYL003
MIFTS: 49

Myeloid Sarcoma malady

Cancer, Blood categories

Summaries for Myeloid Sarcoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to acute myeloid leukemia and acute leukemia. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Hematopoietic cell lineage. The compounds naphthol as-d chloroacetate and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Myeloid Sarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 35MeSH, 40NCIt, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
granulocytic sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

myeloid sarcoma 8 43 10 49
granulocytic sarcoma 8 43 49 61
chloroma 8 43 49
extramedullary myeloid tumor 8 49
myeloid sarcoma without mention of remission 8
myeloid sarcoma in remission 8
myeloid sarcoma, morphology 8
myeloid sarcoma, disease 8
sarcoma granulocytic 45
myeloid sarcoma nos 8
monocytic sarcoma 43
erythroid sarcoma 43


External Ids:

Disease Ontology8 DOID:8683
ICD9CM27 205.3
MeSH35 D023981
MESH via Orphanet36 D023981
ICD10 via Orphanet26 C92.3
SNOMED-CT via Orphanet58 35287006, 94719007
ICD1025 C92.3

Related Diseases for Myeloid Sarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1acute myeloid leukemia31.2NPM1, FLT3
2acute leukemia31.1NPM1, FLT3, MPO, NCAM1, CD33, CD34
3adenoma30.2SPN
4acute myeloid leukemia, adult30.2NPM1, FLT3, NCAM1, CD34
5chronic myeloid leukemia30.2FLT3, MPO, CD33, CD34, PTPRC
6adenocarcinoma30.2SPN, CD34, MYH11, NCAM1
7chronic myelomonocytic leukemia30.0MPO, FLT3
8lymphoblastic lymphoma30.0PTPRC, MPO
9acute promyelocytic leukemia30.0NPM1, FLT3, MPO, NCAM1, CD33, PTPRC
10acute t cell leukemia10.4
11t-cell leukemia10.4
12uterine sarcoma10.3
13vagina sarcoma10.2
14spinal cord sarcoma10.2
15langerhans cell sarcoma10.2
16radiculopathy10.2
17testicular leukemia10.2
18central nervous system leukemia10.2
19appendicitis10.2
20bladder sarcoma10.2
21skin sarcoma10.2
22essential thrombocythemia10.2
23hematopoietic stem cell transplantation10.2
24megakaryocytic leukemia10.0
25juvenile myelomonocytic leukemia10.0
26kaposi's sarcoma10.0
27cauda equina syndrome10.0
28angiosarcoma10.0
29small intestinal sarcoma10.0
30testicular cancer10.0
31young syndrome10.0
32germinoma10.0
33hypereosinophilic syndrome10.0
34lymphoma, large-cell, immunoblastic10.0
35polymyositis10.0
36tetraploidy10.0
37myeloproliferative disorder10.0
38teratoma10.0
39bone fracture10.0
40ureteral obstruction10.0
41conjunctiva squamous cell carcinoma10.0
42polycythemia vera10.0
43obstructive jaundice10.0
44sparganosis10.0
45adult t-cell leukemia10.0
46brain sarcoma10.0
47pyoderma gangrenosum10.0
48breast lymphoma10.0
49n syndrome10.0
50bile duct sarcoma10.0

Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Clinical Features for Myeloid Sarcoma

Drugs & Therapeutics for Myeloid Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Myeloid Sarcoma

Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Search CenterWatch for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

Anatomical Context for Myeloid Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Myeloid Sarcoma:

33
Bone marrow, Lymph node, Spleen, Brain, Heart, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Uterus, Prostate, Testis, Cervix, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Tongue, Appendix, Pineal, Uterus corpus

Animal Models for Myeloid Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Myeloid Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6NPM1, FLT3, CD34, PTPRC, SPN
2MP:00053846.9FUT4, SPN, PTPRC, CD34, NCAM1, FLT3
3MP:00053976.8FUT4, NPM1, FLT3, MPO, CD33, CD34
4MP:00053876.7NPM1, FLT3, MPO, CD33, CD34, PTPRC

Publications for Myeloid Sarcoma

Sources:
51PubMed
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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Gingival myeloid sarcoma in myelodysplastic syndrome. (23288397)
2013
2
Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion. (23314098)
2013
3
Myeloid Sarcoma of the Nasopharynx Mimicking an Aggressive Lymphoma. (24101200)
2013
4
High-grade KIT-negative sarcoma of the small bowel in a patient with chronic myeloid leukemia receiving long-term tyrosine kinase inhibitors. (23439757)
2013
5
Testicular myeloid sarcoma: case report. (23580888)
2013
6
Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model. (23564351)
2013
7
Cutaneous myeloid sarcoma: natural history and biology of an uncommon manifestation of acute myeloid leukemia. (23165700)
2013
8
Clinical Characteristics and Prognosis of 23 Patients With Nonleukemic Myeloid Sarcoma. (23928547)
2013
9
Images in clinical medicine. Myeloid sarcoma. (24328467)
2013
10
Primary granulocytic sarcoma of lip - A rare extramedullary presentation of myeloid leukemia. (24049304)
2013
11
Surgical resection for isolated myeloid sarcoma arising from a rib. (23098984)
2012
12
Ocular myeloid sarcoma in a 10-year-old child. (22296819)
2012
13
Erythroblastic sarcoma, an extremely rare variant of myeloid sarcoma. (22795354)
2012
14
Utility of FDG PET/CT in the assessment of myeloid sarcoma. (22528910)
2012
15
A rare case of myeloid sarcoma presenting as an anorectal ulcer. (22666268)
2012
16
Autopsy case of primary myelofibrosis in which myeloid sarcoma was the initial manifestation of tumor progression. (22612514)
2012
17
Isolated myeloid sarcoma without bone marrow involvement. (22398813)
2012
18
Erythroleukemia presenting with myeloid sarcoma of the lung as detected by immunophenotypic analysis of bronchoalveolar lavage fluid. (22172464)
2012
19
Adult orbital myeloid sarcoma (granulocytic sarcoma): two cases and review of the literature. (23088361)
2012
20
Bilateral myeloid sarcoma of the breast and cerebrospinal fluid as a relapse of acute myeloid leukemia after stem-cell transplantation: a case report. (22734027)
2012
21
Myeloid sarcoma of the uterine cervix presenting as missed abortion. (22791383)
2012
22
Isolated recurrence of intracranial and temporal bone myeloid sarcoma--case report. (22198109)
2011
23
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation. (22185993)
2011
24
Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10A years. (21181316)
2011
25
Myeloid sarcoma in a one-month-old infant. (22110435)
2011
26
Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma. (22050091)
2011
27
Ocular myeloid sarcoma in a 10-year-old child. (22108369)
2011
28
Late relapse of acute myeloblastic leukemia as myeloid sarcoma causing radiculopathy. (20933282)
2010
29
Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium. (20513534)
2010
30
The Hammersmith Hospital hematopathology case of the month: myeloid sarcoma with Langerhans cell proliferation. (20536351)
2010
31
Myeloid sarcoma presenting as an anterior mediastinal mass invading the pericardium: Serial Imaging With F-18 FDG PET/CT. (20706048)
2010
32
Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. (19956024)
2009
33
Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia. (20110001)
2009
34
Myeloid sarcoma of the prostate revealed by urinary retention: a case report. (21686890)
2009
35
Primary myeloid sarcoma of the jejunum and greater omentum causing small intestine obstruction. (19902875)
2009
36
Myeloid sarcoma of the breast mimicking hamartoma on sonography. (19023005)
2008
37
Extramedullary myeloid sarcoma of the breast. (18711198)
2008
38
Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study. (17974004)
2007
39
Acute myeloid leukaemia presenting with mediastinal myeloid sarcoma: report of three cases and review of literature. (17325888)
2007
40
Bilateral orbital myeloid sarcoma as initial manifestation of acute myeloid leukemia. (17522781)
2007
41
PET-imaging as a useful tool for early detection of the relapse site in the management of primary myeloid sarcoma. (17194660)
2006
42
Myeloid sarcoma of the uterus presenting as vaginal bleeding. (16958646)
2006
43
Myeloid sarcoma involving the testis. (16191514)
2005
44
Genomic profiling of myeloid sarcoma by array comparative genomic hybridization. (16080198)
2005
45
Subcutaneous myeloid sarcoma. (15655160)
2005
46
Myeloid sarcoma involving the breast. (15628906)
2005
47
Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue. (8037168)
1994
48
The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat. (2152823)
1990
49
Myeloid sarcoma. Review of the literature and report of a case. (4716779)
1973
50
Myeloid Sarcoma of the Posterior Pillar of the Fauces. (19982933)
1923

Genetic Variations for Myeloid Sarcoma

Expression for genes affiliated with Myeloid Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

Pathways for genes affiliated with Myeloid Sarcoma

Sources:
38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LYZ, CD34, MPO
29.3CD34, CD33, FLT3
38.9MPO, NCAM1, CD34, PTPRC
48.6SPN, PTPRC, CD34, NCAM1

Compounds for genes affiliated with Myeloid Sarcoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Myeloid Sarcoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate4510.2PTPRC, MPO
2monochloroacetic acid4510.1PTPRC, MPO
3gemtuzumab ozogamicin45 1111.0CD33, FLT3
4fluorochrome459.7CD34, PTPRC
5fitc459.6PTPRC, CD34
6polylactosamine459.5FUT4, SPN
7daunorubicin45 50 1111.3NPM1, FLT3, MPO
8[alcl]459.3PTPRC, NPM1
9n-acetyllactosamine45 2410.2FUT4, PTPRC
10hematoxylin459.1NCAM1, MYH11, CD34, PTPRC
11fmlp459.0MPO, PTPRC, SPN, FUT4
12agarose458.9PTPRC, PGM1, FLT3, NPM1
13sialic acid458.9NCAM1, PTPRC, SPN, FUT4
14lactate458.8NPM1, FLT3, MPO, NCAM1
15polysaccharide458.8FUT4, SPN, PTPRC, NCAM1
16vegf458.7FLT3, MPO, NCAM1, MYH11, CD34
17progesterone45 60 29 11 2412.6NCAM1, MYH11, CD34, PTPRC
18threonine458.2NPM1, FLT3, NCAM1, PTPRC, SPN
19estrogen458.1NPM1, NCAM1, MYH11, CD34, PTPRC
20tyrosine457.5NPM1, FLT3, NCAM1, CD33, CD34, PTPRC
21paraffin457.5SPN, NPM1, MPO, NCAM1, MYH11, CD34
22retinoic acid45 247.9NPM1, FLT3, MPO, NCAM1, MYH11, CD34

GO Terms for genes affiliated with Myeloid Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.5SPN, PTPRC, CD34, CD33, FLT3
2cell surfaceGO:0099868.3FLT3, NCAM1, SPN, FUT4
3external side of plasma membraneGO:0098978.2SPN, PTPRC, CD34, CD33, NCAM1

Products for genes affiliated with Myeloid Sarcoma

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  • Lysates
  • Antibodies

Sources for Myeloid Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet