MCID: MYL003
MIFTS: 56

Myeloid Sarcoma malady

Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Myeloid Sarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to sarcoma and acute myeloid leukemia. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are HIF-1-alpha transcription factor network and C-MYB transcription factor network. The compounds gemtuzumab ozogamicin and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Myeloid Sarcoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 46Novoseek, 36MeSH, 41NCIt, 28ICD9CM, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
granulocytic sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

myeloid sarcoma 9 44 11 50
granulocytic sarcoma 9 44 50 63
chloroma 9 44 50
extramedullary myeloid tumor 9 50
myeloid sarcoma without mention of remission 9
myeloid sarcoma in remission 9
myeloid sarcoma, morphology 9
myeloid sarcoma, disease 9
sarcoma granulocytic 46
myeloid sarcoma nos 9
monocytic sarcoma 44
erythroid sarcoma 44


External Ids:

Disease Ontology9 DOID:8683
MeSH36 D023981
ICD9CM28 205.3
MESH via Orphanet37 D023981
ICD10 via Orphanet27 C92.3
SNOMED-CT via Orphanet60 35287006, 94719007
ICD1026 C92.3

Related Diseases for Myeloid Sarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7LYZ, PTPRC, CD34
2acute myeloid leukemia31.2FLT3, NPM1
3myeloid leukemia30.9PTPRC, NPM1, CD33, CD34, MPO, FLT3
4leukemia30.8PTPRC, FUT4, MPO, SPN, FLT3, LYZ
5chronic myelomonocytic leukemia30.1FLT3, MPO
6histiocytosis30.1LYZ, PGM1
7lymphoblastic lymphoma30.1PTPRC, MPO
8myeloproliferative disorder30.1MPO, FLT3
9myelodysplastic syndromes30.1MPO, NPM1, FLT3, CD33, CD34, SPN
10peripheral t-cell lymphoma30.1PTPRC, NCAM1
11acute leukemia30.0NCAM1, PTPRC, MPO, CD34, NPM1, FLT3
12chronic myeloid leukemia29.9MPO, PTPRC, CD34, CD33, FLT3
13acute promyelocytic leukemia29.9PTPRC, NPM1, NCAM1, MPO, FLT3, CD33
14mediastinitis10.3
15duodenitis10.3
16gingivitis10.3
17myelofibrosis10.3
18adenoma10.2
19cervicitis10.2
20meningitis10.2
21appendicitis10.2
22radiculopathy10.2
23adenocarcinoma10.2
24intestinal obstruction10.2
25prostatitis10.2
26vaginitis10.2
27essential thrombocythemia10.2
28hematopoietic stem cell transplantation10.2
29periodontal disease10.1MPO, LYZ
30skin disease10.1LYZ, MPO
31perineurioma10.1CD34
32cork-handlers' disease10.0LYZ, MPO
33leukopenia10.0NCAM1, MPO
34megakaryocytic leukemia10.0
35kaposi's sarcoma10.0
36tonsillitis10.0
37cauda equina syndrome10.0
38adenoiditis10.0
39juvenile myelomonocytic leukemia10.0
40angiosarcoma10.0
41facial paralysis10.0
42hermaphroditism10.0
43lymphoblastic leukemia10.0
44mature teratoma10.0
45microsporidiosis10.0
46testicular cancer10.0
47germinoma10.0
48hypereosinophilic syndrome10.0
49polymyositis10.0
50tetraploidy10.0

Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Symptoms for Myeloid Sarcoma

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Drugs & Therapeutics for Myeloid Sarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Myeloid Sarcoma

Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Search CenterWatch for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

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34MalaCards
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MalaCards organs/tissues related to Myeloid Sarcoma:

34
Myeloid, Bone, Bone marrow, Monocytes, Breast, Liver, Cervix, Skin, Heart, Uterus, Prostate, Kidney, Appendix, Lymph node, Salivary gland, Testis, Small intestine, B cells, Thyroid, Lung, Spleen, Tongue, Brain, Pineal

Animal Models for Myeloid Sarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Myeloid Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9SPN, PTPRC, FLT3, NPM1, CD34
2MP:00053847.4CD34, NPM1, NCAM1, FLT3, PTPRC, FUT4
3MP:00053976.8CD34, SPN, FUT4, PTPRC, MPO, FLT3
4MP:00053876.6SPN, FUT4, PTPRC, MPO, FLT3, NPM1

Publications for Myeloid Sarcoma

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53PubMed
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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Myeloid sarcoma preceding an acute promyelocytic leukaemia with neuromeningeal infiltration. (23716188)
2014
2
De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. (23095217)
2013
3
Myeloid sarcoma developing in prexisting hydroxyurea-induced leg ulcer in a polycythemia vera patient. (24109489)
2013
4
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
5
Gingival myeloid sarcoma in myelodysplastic syndrome. (23288397)
2013
6
A "complicated" fracture: a Philadelphia chromosome-positive myeloid sarcoma of the bone. (23404583)
2013
7
Myeloid sarcoma with megakaryoblastic differentiation mimicking a sellar tumor. (24118374)
2013
8
Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion. (23314098)
2013
9
Gingival swelling and pleural effusion: non-leukemic myeloid sarcoma. (23336824)
2013
10
Myeloid Sarcoma of the Nasopharynx Mimicking an Aggressive Lymphoma. (24101200)
2013
11
Surgical resection for isolated myeloid sarcoma arising from a rib. (23098984)
2012
12
Cutaneous myeloid sarcoma presenting as grey pigmented macules. (22278733)
2012
13
A case of inguinal sparganosis mimicking myeloid sarcoma. (23230335)
2012
14
Ocular myeloid sarcoma in a 10-year-old child. (22296819)
2012
15
Concomitant squamous cell carcinoma and myeloid sarcoma in pre-existing pterygium of the conjunctiva: diagnostic challenges. (22331932)
2012
16
Erythroblastic sarcoma, an extremely rare variant of myeloid sarcoma. (22795354)
2012
17
Isolated recurrence of intracranial and temporal bone myeloid sarcoma--case report. (22198109)
2011
18
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation. (22185993)
2011
19
Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10A years. (21181316)
2011
20
Gastric myeloid sarcoma--a report of two cases addressing diagnostic issues. (22234125)
2011
21
Myeloid sarcoma: clinicopathologic, cytogenetic, and outcome analysis of 21 adult patients. (23213544)
2011
22
Myeloid sarcoma mimicking nasopharyngeal carcinoma. (21747080)
2011
23
Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. (21685467)
2011
24
Butterfly lesion of the corpus callosum: an unusual case of extramedullary myeloid sarcoma (granulocytic sarcoma). (21467855)
2011
25
Post-tonsillectomy pulmonary complication in a patient with tonsillar myeloid sarcoma. (21234822)
2011
26
Unusual nodular bone marrow appearances in a case of myeloid sarcoma. (21554261)
2011
27
Myeloid sarcoma in a child with acute myeloblastic leukaemia. (21711997)
2011
28
Myeloid sarcoma of the vagina: a report of 2 cases. (20354424)
2010
29
Therapy-related myeloid sarcoma with an NPM1 mutation. (20858094)
2010
30
Late relapse of acute myeloblastic leukemia as myeloid sarcoma causing radiculopathy. (20933282)
2010
31
Myeloid sarcoma in the nasal cavities that developed during the course of acute myelomonocytic leukemia. (21123976)
2010
32
Myeloid sarcoma involving the breast. (20698144)
2010
33
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
34
Myeloid sarcoma of the breast mimicking hamartoma on sonography. (19023005)
2008
35
Life-threatening conjunctival presentation of myeloid sarcoma. (19128384)
2008
36
Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. (18623376)
2008
37
Myeloid sarcoma in the central nervous system: case report and review of the literature. (18714643)
2008
38
Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)
2007
39
Myeloid sarcoma presenting as an isolated nodule in a patient with acute myelogenous leukemia. (17668545)
2007
40
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. (17170724)
2007
41
Isolated myeloid sarcoma presenting in all four eyelids. (17667120)
2007
42
Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16). (16740041)
2006
43
Myeloid sarcoma of the extrahepatic bile ducts presenting as obstructive jaundice. (16948823)
2006
44
Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. (17405266)
2006
45
Acute myeloid leukemia with concurrent myeloid sarcoma treated with autologous bone marrow transplantation: two illustrative cases and a literature review. (16273593)
2005
46
Myeloid sarcoma involving the testis. (16191514)
2005
47
Genomic profiling of myeloid sarcoma by array comparative genomic hybridization. (16080198)
2005
48
Primary myeloid sarcoma of the testicle with t(15;17). (15721636)
2005
49
FLT3 mutations in myeloid sarcoma. (15352981)
2004
50
Primary myeloid sarcoma of the gynecologic tract: a report of two cases progressing to acute myeloid leukemia. (12533040)
2002

Variations for Myeloid Sarcoma

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Expression for genes affiliated with Myeloid Sarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

Pathways for genes affiliated with Myeloid Sarcoma

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51PathCards, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology
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Pathways related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPM1, PGM1
29.3MPO, LYZ, CD34
39.3CD34, CD33, FLT3
48.7CD34, NCAM1, MPO, PTPRC
58.4CD34, NCAM1, PTPRC, SPN

Compounds for genes affiliated with Myeloid Sarcoma

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Sources:
52PharmGKB, 46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Myeloid Sarcoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1gemtuzumab ozogamicin52 46 1212.1CD33, FLT3
2monochloroacetic acid4610.1PTPRC, MPO
3naphthol as-d chloroacetate4610.1PTPRC, MPO
4[alcl]469.9PTPRC, NPM1
5fluorescein46 1210.9PTPRC, MPO
6mitoxantrone46 52 1211.8FLT3, MPO
7daunorubicin46 52 1211.8NPM1, FLT3, MPO
8fluorochrome469.8CD34, PTPRC
9fitc469.7CD34, PTPRC
10cytochalasin b469.6MPO, SPN
11n-acetyllactosamine46 2510.4PTPRC, FUT4
12polylactosamine469.3FUT4, SPN
13histamine46 30 2511.3NCAM1, MPO, PTPRC
14hematoxylin469.3PTPRC, NCAM1, CD34
15methylcellulose469.3CD34, FLT3
16lactate469.3MPO, FLT3, NCAM1, NPM1
17agarose469.3PTPRC, PGM1, FLT3, NPM1
1812-o-tetradecanoylphorbol 13-acetate469.2PTPRC, NCAM1, CD34
19doxorubicin46 52 1211.1FLT3, NCAM1, NPM1
20vegf469.0CD34, NCAM1, FLT3, MPO
21estrogen468.7PTPRC, NCAM1, NPM1, CD34
22fmlp468.7SPN, FUT4, PTPRC, MPO
23threonine468.5SPN, PTPRC, FLT3, NCAM1, NPM1
24sialic acid468.4NCAM1, PTPRC, FUT4, SPN
25polysaccharide468.4NCAM1, PTPRC, FUT4, SPN
26calcium46 52 25 1211.2SPN, PTPRC, MPO, NCAM1, NPM1, CD33
27paraffin468.1CD34, NPM1, NCAM1, MPO, PTPRC, SPN
28tyrosine467.7SPN, PTPRC, FLT3, NCAM1, NPM1, CD33
29retinoic acid46 258.4SPN, FUT4, MPO, FLT3, NCAM1, NPM1

GO Terms for genes affiliated with Myeloid Sarcoma

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17Gene Ontology
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Cellular components related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.4LYZ, PGM1, MPO, PTPRC, SPN
2external side of plasma membraneGO:0098978.1SPN, CD34, CD33, NCAM1, PTPRC
3cell surfaceGO:0099868.0SPN, FUT4, FLT3, NCAM1
4integral component of plasma membraneGO:0058877.9CD34, SPN, PTPRC, FLT3, CD33

Biological processes related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemopoiesisGO:0300979.6CD34, FLT3
2positive regulation of T cell proliferationGO:0421029.4SPN, PTPRC
3negative regulation of cell proliferationGO:0082859.2CD33, FLT3, NPM1
4signal transductionGO:0071658.6CD34, SPN, NPM1, CD33

Products for genes affiliated with Myeloid Sarcoma

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  • Antibodies
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Sources for Myeloid Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet