MCID: MYL003
MIFTS: 56

Myeloid Sarcoma malady

Rare diseases, Cancer diseases, Blood diseases categories
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Summaries for Myeloid Sarcoma

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Wikipedia:65 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards based summary: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to acute myeloid leukemia and sarcoma. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are HIF-1-alpha transcription factor network and C-MYB transcription factor network. The compounds gemtuzumab ozogamicin and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Myeloid Sarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Myeloid Sarcoma, Aliases & Descriptions:

Name: Myeloid Sarcoma 8 42 10 48
Granulocytic Sarcoma 8 42 48 62
Extramedullary Myeloid Tumor 8 48 62
Chloroma 8 42 48
Myeloid Sarcoma Without Mention of Remission 8 62
Myeloid Sarcoma in Remission 8 62
 
Myeloid Sarcoma, Morphology 8
Myeloid Sarcoma, Disease 8
Sarcoma Granulocytic 44
Myeloid Sarcoma Nos 8
Monocytic Sarcoma 42
Erythroid Sarcoma 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
granulocytic sarcoma:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:8683
MeSH34 D023981
ICD9CM27 205.3
ICD10 via Orphanet26 C92.3
MESH via Orphanet35 D023981
ICD1025 C92.3

Related Diseases for Myeloid Sarcoma

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Diseases related to Myeloid Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1acute myeloid leukemia31.6NPM1, FLT3
2sarcoma31.5PTPRC, LYZ, CD34
3histiocytosis30.4LYZ, PGM1
4lymphoblastic lymphoma30.4MPO, PTPRC
5myeloid leukemia30.2PTPRC, MPO, FLT3, NPM1, CD33, CD34
6peripheral t-cell lymphoma30.2NCAM1, PTPRC
7myelodysplastic syndromes29.6SPN, MPO, FLT3, NPM1, CD33, CD34
8leukemia29.4SPN, FUT4, PTPRC, MPO, FLT3, LYZ
9chronic myeloid leukemia29.4PTPRC, MPO, FLT3, CD33, CD34
10acute lymphoblastic leukemia29.4PTPRC, MPO, FLT3, CD33, CD34
11acute promyelocytic leukemia29.3PTPRC, MPO, FLT3, NCAM1, NPM1, CD33
12acute leukemia29.0PTPRC, MPO, FLT3, NCAM1, NPM1, CD33
13duodenitis10.3
14mediastinitis10.3
15pdgfrb-associated chronic eosinophilic leukemia10.3FLT3, MPO
16skin disease10.3MPO, LYZ
17hematopoietic stem cell transplantation10.3
18myelofibrosis10.3
19gingivitis10.3
20periodontal disease10.3MPO, LYZ
21perineurioma10.3CD34
22colon adenoma10.2
23adenoma10.2
24cervicitis10.2
25meningitis10.2
26cork-handlers' disease10.2LYZ, MPO
27radiculopathy10.2
28appendicitis10.2
29adenocarcinoma10.2
30intestinal obstruction10.2
31prostatitis10.2
32vaginitis10.2
33acute myelomonocytic leukemia10.2
34essential thrombocythemia10.2
35leukopenia10.2MPO, NCAM1
36bone marrow cancer10.1FLT3, MPO
37reticulosarcoma10.1NPM1, PTPRC
38hypersensitivity reaction type ii disease10.1NCAM1, LYZ, MPO
39leukemia, acute nonlymphocytic10.1CD34, CD33
40hairy cell leukemia10.1FLT3, PTPRC
41malignant fibroxanthoma10.1LYZ, CD34
42embryonal rhabdomyosarcoma10.1PTPRC, NCAM1
43neuroendocrine carcinoma10.1NCAM1, PTPRC
44anaplastic large cell lymphoma10.0PTPRC, NPM1
45juvenile myelomonocytic leukemia10.0
46adenoiditis10.0
47kaposi's sarcoma10.0
48tonsillitis10.0
49cauda equina syndrome10.0
50germinoma10.0

Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Symptoms for Myeloid Sarcoma

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Drugs & Therapeutics for Myeloid Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

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MalaCards organs/tissues related to Myeloid Sarcoma:

32
Myeloid, Bone, Bone marrow, Monocytes, Breast, Liver, Cervix, Heart, Kidney, Skin, Uterus, Prostate, Appendix, Lymph node, Spleen, Brain, Small intestine, Lung, Thyroid, Salivary gland, Testis, B cells, Tongue, Pineal

Animal Models for Myeloid Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Myeloid Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9SPN, PTPRC, FLT3, NPM1, CD34
2MP:00053847.4CD34, NPM1, NCAM1, FLT3, PTPRC, FUT4
3MP:00053976.8CD34, SPN, FUT4, PTPRC, MPO, FLT3
4MP:00053876.6SPN, FUT4, PTPRC, MPO, FLT3, NPM1

Publications for Myeloid Sarcoma

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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Myeloid sarcoma as the presenting symptom of chronic myelogenous leukemia blast crisis. (24982578)
2014
2
Myeloid sarcoma preceding an acute promyelocytic leukaemia with neuromeningeal infiltration. (23716188)
2014
3
Oral myeloid sarcoma: two case reports. (25159834)
2014
4
De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. (23095217)
2013
5
Myeloid sarcoma developing in prexisting hydroxyurea-induced leg ulcer in a polycythemia vera patient. (24109489)
2013
6
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
7
Gingival myeloid sarcoma in myelodysplastic syndrome. (23288397)
2013
8
A "complicated" fracture: a Philadelphia chromosome-positive myeloid sarcoma of the bone. (23404583)
2013
9
Myeloid sarcoma with megakaryoblastic differentiation mimicking a sellar tumor. (24118374)
2013
10
Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p-deletion. (23314098)
2013
11
Gingival swelling and pleural effusion: non-leukemic myeloid sarcoma. (23336824)
2013
12
Surgical resection for isolated myeloid sarcoma arising from a rib. (23098984)
2012
13
Cutaneous myeloid sarcoma presenting as grey pigmented macules. (22278733)
2012
14
A case of inguinal sparganosis mimicking myeloid sarcoma. (23230335)
2012
15
Ocular myeloid sarcoma in a 10-year-old child. (22296819)
2012
16
Concomitant squamous cell carcinoma and myeloid sarcoma in pre-existing pterygium of the conjunctiva: diagnostic challenges. (22331932)
2012
17
Isolated recurrence of intracranial and temporal bone myeloid sarcoma--case report. (22198109)
2011
18
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation. (22185993)
2011
19
Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10A years. (21181316)
2011
20
Gastric myeloid sarcoma--a report of two cases addressing diagnostic issues. (22234125)
2011
21
Myeloid sarcoma: clinicopathologic, cytogenetic, and outcome analysis of 21 adult patients. (23213544)
2011
22
Myeloid sarcoma mimicking nasopharyngeal carcinoma. (21747080)
2011
23
Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. (21685467)
2011
24
Butterfly lesion of the corpus callosum: an unusual case of extramedullary myeloid sarcoma (granulocytic sarcoma). (21467855)
2011
25
Post-tonsillectomy pulmonary complication in a patient with tonsillar myeloid sarcoma. (21234822)
2011
26
Unusual nodular bone marrow appearances in a case of myeloid sarcoma. (21554261)
2011
27
Myeloid sarcoma in a child with acute myeloblastic leukaemia. (21711997)
2011
28
Myeloid sarcoma of the vagina: a report of 2 cases. (20354424)
2010
29
Therapy-related myeloid sarcoma with an NPM1 mutation. (20858094)
2010
30
Late relapse of acute myeloblastic leukemia as myeloid sarcoma causing radiculopathy. (20933282)
2010
31
Myeloid sarcoma in the nasal cavities that developed during the course of acute myelomonocytic leukemia. (21123976)
2010
32
Myeloid sarcoma involving the breast. (20698144)
2010
33
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
34
Myeloid sarcoma of the breast mimicking hamartoma on sonography. (19023005)
2008
35
Life-threatening conjunctival presentation of myeloid sarcoma. (19128384)
2008
36
Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. (18623376)
2008
37
Myeloid sarcoma in the central nervous system: case report and review of the literature. (18714643)
2008
38
Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)
2007
39
Myeloid sarcoma presenting as an isolated nodule in a patient with acute myelogenous leukemia. (17668545)
2007
40
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. (17170724)
2007
41
Isolated myeloid sarcoma presenting in all four eyelids. (17667120)
2007
42
Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16). (16740041)
2006
43
Myeloid sarcoma of the extrahepatic bile ducts presenting as obstructive jaundice. (16948823)
2006
44
Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. (17405266)
2006
45
Acute myeloid leukemia with concurrent myeloid sarcoma treated with autologous bone marrow transplantation: two illustrative cases and a literature review. (16273593)
2005
46
Myeloid sarcoma involving the testis. (16191514)
2005
47
Genomic profiling of myeloid sarcoma by array comparative genomic hybridization. (16080198)
2005
48
Primary myeloid sarcoma of the testicle with t(15;17). (15721636)
2005
49
FLT3 mutations in myeloid sarcoma. (15352981)
2004
50
Primary myeloid sarcoma of the gynecologic tract: a report of two cases progressing to acute myeloid leukemia. (12533040)
2002

Variations for Myeloid Sarcoma

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Expression for genes affiliated with Myeloid Sarcoma

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Expression patterns in normal tissues for genes affiliated with Myeloid Sarcoma

Search GEO for disease gene expression data for Myeloid Sarcoma.

Pathways for genes affiliated with Myeloid Sarcoma

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Pathways related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPM1, PGM1
29.3MPO, LYZ, CD34
39.3CD34, CD33, FLT3
48.7CD34, NCAM1, MPO, PTPRC
58.4CD34, NCAM1, PTPRC, SPN

Compounds for genes affiliated with Myeloid Sarcoma

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Sources:
50PharmGKB, 44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Myeloid Sarcoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1gemtuzumab ozogamicin50 44 1112.1CD33, FLT3
2monochloroacetic acid4410.1PTPRC, MPO
3naphthol as-d chloroacetate4410.1PTPRC, MPO
4[alcl]449.9PTPRC, NPM1
5fluorescein44 1110.9PTPRC, MPO
6mitoxantrone44 50 1111.8FLT3, MPO
7daunorubicin44 50 1111.8NPM1, FLT3, MPO
8fluorochrome449.8CD34, PTPRC
9fitc449.7CD34, PTPRC
10cytochalasin b449.6MPO, SPN
11n-acetyllactosamine44 2410.4PTPRC, FUT4
12polylactosamine449.3FUT4, SPN
13histamine44 28 2411.3NCAM1, MPO, PTPRC
14hematoxylin449.3PTPRC, NCAM1, CD34
15methylcellulose449.3CD34, FLT3
16lactate449.3MPO, FLT3, NCAM1, NPM1
17agarose449.3PTPRC, PGM1, FLT3, NPM1
1812-o-tetradecanoylphorbol 13-acetate449.2PTPRC, NCAM1, CD34
19doxorubicin44 50 1111.1FLT3, NCAM1, NPM1
20vegf449.0CD34, NCAM1, FLT3, MPO
21estrogen448.7PTPRC, NCAM1, NPM1, CD34
22fmlp448.7SPN, FUT4, PTPRC, MPO
23threonine448.5SPN, PTPRC, FLT3, NCAM1, NPM1
24sialic acid448.4NCAM1, PTPRC, FUT4, SPN
25polysaccharide448.4NCAM1, PTPRC, FUT4, SPN
26calcium44 50 24 1111.2SPN, PTPRC, MPO, NCAM1, NPM1, CD33
27paraffin448.1CD34, NPM1, NCAM1, MPO, PTPRC, SPN
28tyrosine447.7SPN, PTPRC, FLT3, NCAM1, NPM1, CD33
29retinoic acid44 248.4SPN, FUT4, MPO, FLT3, NCAM1, NPM1

GO Terms for genes affiliated with Myeloid Sarcoma

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Cellular components related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.4LYZ, PGM1, MPO, PTPRC, SPN
2external side of plasma membraneGO:0098978.1CD34, CD33, NCAM1, PTPRC, SPN
3cell surfaceGO:0099868.0SPN, FUT4, FLT3, NCAM1
4integral component of plasma membraneGO:0058877.9SPN, PTPRC, FLT3, CD33, CD34

Biological processes related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemopoiesisGO:0300979.6CD34, FLT3
2positive regulation of T cell proliferationGO:0421029.4PTPRC, SPN
3negative regulation of cell proliferationGO:0082859.2CD33, NPM1, FLT3
4signal transductionGO:0071658.6SPN, NPM1, CD33, CD34

Products for genes affiliated with Myeloid Sarcoma

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Sources for Myeloid Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet