MCID: MYL003
MIFTS: 54

Myeloid Sarcoma malady

Cancer diseases, Blood diseases categories

Summaries for Myeloid Sarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A myeloid sarcoma (chloroma, granulocytic sarcoma,extramedullary myeloid tumor), is a solid tumor... more...

MalaCards: Myeloid Sarcoma, also known as granulocytic sarcoma, is related to sarcoma and acute myeloid leukemia. An important gene associated with Myeloid Sarcoma is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Hematopoietic cell lineage. The compounds naphthol as-d chloroacetate and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Myeloid Sarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 27ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
granulocytic sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

myeloid sarcoma 8 42 10 48
granulocytic sarcoma 8 42 48 60
chloroma 8 42 48
extramedullary myeloid tumor 8 48
myeloid sarcoma without mention of remission 8
myeloid sarcoma in remission 8
myeloid sarcoma, morphology 8
myeloid sarcoma, disease 8
sarcoma granulocytic 44
myeloid sarcoma nos 8
monocytic sarcoma 42
erythroid sarcoma 42


External Ids:

Disease Ontology8 DOID:8683
ICD9CM27 205.3
MeSH34 D023981
MESH via Orphanet35 D023981
ICD10 via Orphanet26 C92.3
SNOMED-CT via Orphanet57 35287006, 94719007
ICD1025 C92.3

Related Diseases for Myeloid Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myeloid Sarcoma:



Diseases related to myeloid sarcoma

Clinical Features for Myeloid Sarcoma

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Drugs & Therapeutics for Myeloid Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myeloid Sarcoma

Search NIH Clinical Center for Myeloid Sarcoma

Search CenterWatch for Myeloid Sarcoma

Genetic Tests for Myeloid Sarcoma

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Anatomical Context for Myeloid Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Myeloid Sarcoma:

32
Myeloid, Bone, Bone marrow, Monocytes, Breast, Liver, Cervix, Heart, Uterus, Skin, Prostate, Kidney, Appendix, Lymph node, Colon, Small intestine, Salivary gland, B cells, Testis, Thyroid, Spleen, Lung, Brain, Tongue, Pineal

Animal Models for Myeloid Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloid Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6NPM1, FLT3, CD34, PTPRC, SPN
2MP:00053846.9FUT4, SPN, PTPRC, CD34, NCAM1, FLT3
3MP:00053976.8FUT4, NPM1, FLT3, MPO, CD33, CD34
4MP:00053876.7NPM1, FLT3, MPO, CD33, CD34, PTPRC

Publications for Myeloid Sarcoma

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50PubMed
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Articles related to Myeloid Sarcoma:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Testicular myeloid sarcoma: case report. (23580888)
2013
2
A case of nonleukemic myeloid sarcoma with FIP1L1-PDGFRA rearrangement: an unusual presentation of a rare disease. (23232855)
2013
3
Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge. (24109526)
2013
4
Cutaneous myeloid sarcoma presenting as grey pigmented macules. (22278733)
2012
5
A case of inguinal sparganosis mimicking myeloid sarcoma. (23230335)
2012
6
Ocular myeloid sarcoma in a 10-year-old child. (22296819)
2012
7
Utility of FDG PET/CT in the assessment of myeloid sarcoma. (22528910)
2012
8
Primary nasal histiocytic sarcoma of macrophage-myeloid cell type in a cat. (22520253)
2012
9
A rare case of myeloid sarcoma presenting as an anorectal ulcer. (22666268)
2012
10
Aberrant expression of myeloid and B cell markers in an aggressive multiple-site myeloid sarcoma. (22134831)
2012
11
MRI for evaluation of myeloid sarcoma in adults: a single-institution 10-year experience. (23169708)
2012
12
Low back pain and lumbar radiculopathy as harbingers of acute myeloid leukemia recurrence in a patient with myeloid sarcoma. (22546081)
2012
13
Erythroleukemia presenting with myeloid sarcoma of the lung as detected by immunophenotypic analysis of bronchoalveolar lavage fluid. (22172464)
2012
14
Complete response of myeloid sarcoma with FIP1L1-PDGFRA -associated myeloproliferative neoplasms to imatinib mesylate monotherapy. (22722648)
2012
15
Isolated vaginal myeloid sarcoma in a 16-year-old girl. (21658983)
2012
16
Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: a report from the Children's Oncology Group. (21618422)
2012
17
Pineal region myeloid sarcoma. (22560847)
2012
18
Isolated intracranial myeloid sarcoma. (22990280)
2012
19
Myeloid sarcoma of the heart. (22506643)
2012
20
Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10A years. (21181316)
2011
21
Myeloid sarcoma mimicking nasopharyngeal carcinoma. (21747080)
2011
22
Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. (21685467)
2011
23
Primary myeloid sarcoma with megakaryocytic differentiation in lymph nodes and skin. (21934262)
2011
24
Nonleukemic myeloid sarcoma of the liver: a case report and review of literature. (21484146)
2011
25
Myeloid sarcoma with t(11;19)(q23;p13.3) (MLL-ELL) in the uterine cervix. (21501132)
2011
26
State of the art in myeloid sarcoma. (21883967)
2011
27
Morphological diagnosis of myeloid sarcomas]. (20131502)
2009
28
Primary myelofibrosis relapsed with duodenal myeloid sarcoma after allogeneic stem cell transplantation. (19860605)
2009
29
Extensive involvement of the gastrointestinal tract by a de novo presentation of the monoblastic type of myeloid sarcoma: a case report of a rare entity that is often misdiagnosed. (20010158)
2009
30
Myeloid sarcoma of the stomach. (19028230)
2008
31
Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma: a retrospective study from the SFGM-TC. (18606981)
2008
32
Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)
2007
33
Isolated myeloid sarcoma presenting in all four eyelids. (17667120)
2007
34
Intracranial myeloid sarcoma: conventional and advanced MRI findings. (17684068)
2007
35
Acute myeloid leukaemia presenting with mediastinal myeloid sarcoma: report of three cases and review of literature. (17325888)
2007
36
Acute myeloid leukemia presenting as obstructive jaundice caused by granulocytic sarcoma. (20485638)
2007
37
Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16). (16740041)
2006
38
Megakaryoblastic differentiation of myeloid sarcoma in a patient with essential thrombocythemia. (17107920)
2006
39
Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature. (16707383)
2006
40
Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia. (16574551)
2006
41
Acute myeloid leukemia with concurrent myeloid sarcoma treated with autologous bone marrow transplantation: two illustrative cases and a literature review. (16273593)
2005
42
Primary myeloid sarcoma of the testicle with t(15;17). (15721636)
2005
43
Myeloid sarcoma of appendix mimicking acute appendicitis. (16048393)
2005
44
Bilateral orbital myeloid sarcoma as initial sign of acute myeloid leukemia: case report and review of the literature. (12523908)
2003
45
Myeloid sarcoma of both kidneys, the brain, and multiple bones in a nonleukemic child. (12950136)
2003
46
c-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma. (11698000)
2001
47
Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue. (8037168)
1994
48
Myeloid Sarcoma of the Tibia. Resection of Upper Third of Tibia, followed by Bolting of the Bones together with Living Fibula. (19975614)
1912
49
Excision of Large Myeloid Sarcoma of the Ischium. (19975696)
1912
50
Excision of the Upper End of the Tibia for Myeloid Sarcoma as a Substitute for Amputation: With a Record of Two Cases. (20757973)
1898

Genetic Variations for Myeloid Sarcoma

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Expression for genes affiliated with Myeloid Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloid Sarcoma

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Pathways for genes affiliated with Myeloid Sarcoma

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37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LYZ, CD34, MPO
29.3CD34, CD33, FLT3
38.9MPO, NCAM1, CD34, PTPRC
48.6SPN, PTPRC, CD34, NCAM1

Compounds for genes affiliated with Myeloid Sarcoma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Myeloid Sarcoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate4410.2PTPRC, MPO
2monochloroacetic acid4410.1PTPRC, MPO
3gemtuzumab ozogamicin44 1111.0CD33, FLT3
4fluorochrome449.7CD34, PTPRC
5fitc449.6PTPRC, CD34
6polylactosamine449.5FUT4, SPN
7daunorubicin44 49 1111.3NPM1, FLT3, MPO
8[alcl]449.3PTPRC, NPM1
9n-acetyllactosamine44 2410.2FUT4, PTPRC
10hematoxylin449.1NCAM1, MYH11, CD34, PTPRC
11fmlp449.0MPO, PTPRC, SPN, FUT4
12agarose448.9PTPRC, PGM1, FLT3, NPM1
13sialic acid448.9NCAM1, PTPRC, SPN, FUT4
14lactate448.8NPM1, FLT3, MPO, NCAM1
15polysaccharide448.8FUT4, SPN, PTPRC, NCAM1
16vegf448.7FLT3, MPO, NCAM1, MYH11, CD34
17progesterone44 59 28 11 2412.6NCAM1, MYH11, CD34, PTPRC
18threonine448.2NPM1, FLT3, NCAM1, PTPRC, SPN
19estrogen448.1NPM1, NCAM1, MYH11, CD34, PTPRC
20tyrosine447.5NPM1, FLT3, NCAM1, CD33, CD34, PTPRC
21paraffin447.5SPN, NPM1, MPO, NCAM1, MYH11, CD34
22retinoic acid44 247.9NPM1, FLT3, MPO, NCAM1, MYH11, CD34

GO Terms for genes affiliated with Myeloid Sarcoma

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16Gene Ontology
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Cellular components related to Myeloid Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.5FLT3, CD33, CD34, PTPRC, SPN
2cell surfaceGO:0099868.3NCAM1, SPN, FUT4, FLT3
3external side of plasma membraneGO:0098978.2CD34, NCAM1, SPN, PTPRC, CD33

Products for genes affiliated with Myeloid Sarcoma

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Sources for Myeloid Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet