MCID: MYL007
MIFTS: 53

Myeloma malady

Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Blood diseases categories

Summaries for Myeloma

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Disease Ontology:9 A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.

MalaCards based summary: Myeloma, also known as multiple myeloma, is related to multiple myeloma and plasmacytoma. An important gene associated with Myeloma is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Immune response IL 12 signaling pathway and Jak/Stat Pathway. The drugs carmustine and cisplatin and the compounds pd 173074 and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Myeloma

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Sources:
60UMLS, 9Disease Ontology, 11DISEASES, 43Novoseek
See all sources

Myeloma, Aliases & Descriptions:

Name: Myeloma 9 11 43
 
Multiple Myeloma 60


Classifications:



External Ids:

Disease Ontology9 DOID:0070004

Related Diseases for Myeloma

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Diseases in the Myeloma family:

Multiple Myeloma Familial Myeloma

Diseases related to Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 425)
idRelated DiseaseScoreTop Affiliating Genes
1multiple myeloma32.8CCND1, FGFR3
2plasmacytoma31.7IL6R, IRF4
3leukemia31.4IRF4, STAT5A, CCND1, IL6R, FGFR3
4hodgkin lymphoma31.0FGFR3, IL6R, IRF4
5waldenstrom macroglobulinemia30.9CCND1, IRF4
6b-cell lymphomas30.7IRF4, STAT5A, CCND1
7prostate cancer30.5ADAM9, DKK1, STAT5A, CCND1, IL6R, FGFR3
8malt lymphoma30.2CCND1, IRF4
9burkitt lymphoma30.0FGFR3, IL6R, CCND1, STAT5A, IRF4
10amyloidosis10.7
11plasma cell leukemia10.7
12endotheliitis10.6
13osteosclerotic myeloma10.6
14smoldering myeloma10.6
15hematopoietic stem cell transplantation10.5
16extramedullary plasmacytoma10.5
17al amyloidosis10.5
18macroglobulinemia10.5
19neuropathy10.5
20poems syndrome10.5
21chronic lymphocytic leukemia10.4
22pleomorphic adenoma10.4LECT1
23fanconi syndrome10.4
24non-secretory myeloma10.4
25peripheral neuropathy10.4
26light chain deposition disease10.4
27polyneuropathy10.4
28cutis laxa10.4
29glomerulonephritis10.4
30purpura10.3
31hypoxia10.3
32myelodysplastic syndrome10.3
33hypercalcemia10.3
34acquired cutis laxa10.3
35cryoglobulinemia10.3
36subcorneal pustular dermatosis10.3
37indolent myeloma10.3
38necrobiotic xanthogranuloma10.3
39familial myeloma10.3
40acute leukemia10.3
41arthritis10.3
42hepatitis10.3
43osteonecrosis10.3
44prostatitis10.3
45macroglossia10.3
46osteonecrosis of the jaw10.3
47myeloid leukemia10.2
48insulin-like growth factor i10.2
49keratopathy10.2
50gaucher's disease10.2

Graphical network of the top 20 diseases related to Myeloma:



Diseases related to myeloma

Symptoms for Myeloma

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Drugs & Therapeutics for Myeloma

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Genetic Tests for Myeloma

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Anatomical Context for Myeloma

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MalaCards organs/tissues related to Myeloma:

31
Bone, Bone marrow, B cells, T cells, Endothelial, Kidney, Lung, Skin, Testis, Myeloid, Neutrophil, Testes, Monocytes, Nk cells, Breast, Prostate, Liver, Pituitary, Heart, Whole blood, Thyroid, Spinal cord, Colon, Lymph node, Pancreas, Tongue, Brain, Skeletal muscle, Ovary

Animal Models for Myeloma or affiliated genes

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MGI Mouse Phenotypes related to Myeloma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9FGFR3, IL6R, CCND1, STAT5A, IRF4
2MP:00028739.4FGFR3, DAZAP2, LECT1, ADAM9, STAT5A, CCND1
3MP:00053768.9LECT1, NBEA, DKK1, STAT5A, CCND1, IL6R

Publications for Myeloma

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Articles related to Myeloma:

(show top 50)    (show all 4094)
idTitleAuthorsYear
1
Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis. (25898974)
2015
2
Cryptosporidiosis causing severe persistent diarrhea in a patient with multiple myeloma: A Case report and brief review of literature. (25006294)
2014
3
Treatment of multiple myeloma bone disease: experimental and clinical data. (25388648)
2014
4
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
2013
5
An old drug with a new future: bendamustine in multiple myeloma. (24053161)
2013
6
Cytogenetic classification in Korean multiple myeloma patients: Prognostic significance of hyperdiploidy with 47 to 50 chromosomes and the number of structural abnormalities. (24372944)
2013
7
How to determine bortezomib-based regimen for elderly patients with multiple myeloma: PAD versus CBd, an observational study. (24337419)
2013
8
Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. (23446999)
2013
9
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma-to strengthen the case toward renal replacement therapy? (25356216)
2013
10
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (22792345)
2012
11
Effects of short-hairpin RNA-inhibited I^-catenin expression on the growth of human multiple myeloma cells in vitro and in vivo. (22609776)
2012
12
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. (21420464)
2011
13
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
2010
14
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
15
Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (19762082)
2010
16
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. (20920357)
2010
17
Potentiation of (-)-epigallocatechin-3-gallate-induced apoptosis by bortezomib in multiple myeloma cells. (20011976)
2009
18
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling. (19755988)
2009
19
MDR1 diplotypes as prognostic markers in multiple myeloma. (18408561)
2008
20
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
21
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth. (17545613)
2007
22
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. (17640854)
2007
23
Heterogeneous expression of CD32 and CD32-mediated growth suppression in human myeloma cells. (16818279)
2006
24
Chemokines in multiple myeloma. (16982321)
2006
25
The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (17043023)
2006
26
Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells. (16396777)
2006
27
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. (15902294)
2005
28
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
2005
29
CIDP and isolated osteosclerotic myeloma. (15623724)
2004
30
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma. (15629043)
2004
31
Advances in biology and therapy of multiple myeloma. (14633785)
2003
32
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
2000
33
CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. (9823960)
1998
34
Interleukin-2-mediated modulation of plasma cell tumor growth in a model of multiple myeloma. (9458238)
1998
35
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
1998
36
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma. (9373192)
1997
37
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
1997
38
Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone. (8977259)
1996
39
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
40
Interferon-gamma in multiple myeloma. (8535185)
1995
41
Optimal blood stem cell mobilization using 10 micrograms/kg granulocyte colony-stimulating factor (G-CSF) alone for high-dose melphalan intensification in multiple myeloma: an intrapatient controlled study. (7522395)
1994
42
Objective response of multiple myeloma to cyclosporin A. (7696923)
1994
43
Potential use of IgA protease therapy in IgA myeloma patients. (8502191)
1993
44
Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. (1391937)
1992
45
Myeloma phenotype: clues to disease origin and manifestation. (1582972)
1992
46
In vitro growth pattern of myeloma cells in liquid suspension or semi-solid culture containing interleukin-6. (1954351)
1991
47
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. (2031968)
1991
48
Analysis of methylation in the c-MYC gene in five human myeloma cell lines. (2004018)
1991
49
Chronic neutrophilic leukemia and myeloma. Report on long survival. (6585081)
1984
50
Panhypopituitarism due to multiple myeloma. (5415797)
1970

Variations for Myeloma

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Clinvar genetic disease variations for Myeloma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564

Expression for genes affiliated with Myeloma

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Search GEO for disease gene expression data for Myeloma.

Pathways for genes affiliated with Myeloma

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Pathways related to Myeloma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IRF4, STAT5A
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
10.2CCND1, STAT5A
310.2CCND1, STAT5A
410.2CCND1, STAT5A
5
Show member pathways
Type III interferon signaling36
10.1IL6R, CCND1, STAT5A

Compounds for genes affiliated with Myeloma

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Compounds related to Myeloma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1pd 17307443 5911.2FGFR3, CCND1
2thalidomide43 49 59 1213.0FGFR3, IL6R, CCND1, DKK1
3progesterone43 28 59 24 1213.9IL6R, CCND1, STAT5A, DKK1
4imatinib43 49 1211.8FGFR3, CCND1, STAT5A
5vegf439.7LECT1, STAT5A, CCND1, IL6R, FGFR3

GO Terms for genes affiliated with Myeloma

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Cellular components related to Myeloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:000998610.0FGFR3, IL6R, MICA, ADAM9

Biological processes related to Myeloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:004508610.2STAT5A, IRF4
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2IL6R, FGFR3
3negative regulation of transcription from RNA polymerase II promoterGO:000012210.0FGFR3, WHSC1, CCND1, DKK1
4JAK-STAT cascadeGO:00072599.9STAT5A, FGFR3

Molecular functions related to Myeloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055158.7FGFR3, C1orf35, FCRL4, IRF4, ADAM9, DKK1

Products for genes affiliated with Myeloma

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  • Antibodies
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  • Proteins
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Sources for Myeloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet