MCID: MYL007
MIFTS: 61

Myeloma malady

Genetic diseases, Cancer diseases, Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases categories
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Summaries for Myeloma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.

MalaCards: Myeloma, also known as multiple myeloma, is related to multiple myeloma and leukemia. An important gene associated with Myeloma is IRF4 (interferon regulatory factor 4), and among its related pathways are Immune response IL 12 signaling pathway and Jak/Stat Pathway. The drugs cyclophosphamide and thalidomide and the compounds pd 173074 and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are tumorigenesis and normal.

Wikipedia:65 Plasma cell myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as multiple myeloma or Kahler\'s... more...

Aliases & Classifications for Myeloma

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62UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek
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Classifications:



Aliases & Descriptions:

myeloma 8 10 45
multiple myeloma 62


External Ids:

Disease Ontology8 DOID:0070004

Related Diseases for Myeloma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Multiple Myeloma family:

myeloma Familial Myeloma

Diseases related to Myeloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 449)
idRelated DiseaseScoreTop Affiliating Genes
1multiple myeloma32.4CCND1, FGFR3
2leukemia31.3FGFR3, CCND1, STAT5A, IRF4, IL6R
3plasmacytoma31.3IL6R, IRF4
4hodgkin's lymphoma30.9FGFR3, IRF4, IL6R
5b-cell lymphomas30.3IRF4, STAT5A, CCND1
6non-hodgkin lymphoma30.3CCND1, IL6R, IRF4
7prostate cancer30.3FGFR3, IL6R, CCND1, STAT5A, DKK1, ADAM9
8malt lymphoma29.8IRF4, CCND1
9amyloidosis10.7
10plasma cell leukemia10.6
11endotheliitis10.6
12osteosclerotic myeloma10.6
13smoldering myeloma10.6
14hematopoietic stem cell transplantation10.5
15al amyloidosis10.5
16macroglobulinemia10.5
17extramedullary plasmacytoma10.5
18neuropathy10.5
19poems syndrome10.4
20chronic lymphocytic leukemia10.4
21fanconi syndrome10.4
22non-secretory myeloma10.4
23peripheral neuropathy10.4
24polyneuropathy10.4
25light chain deposition disease10.4
26cutis laxa10.3
27glomerulonephritis10.3
28purpura10.3
29hypercalcemia10.3
30cryoglobulinemia10.3
31hepatitis10.3
32myelodysplastic syndromes10.3
33familial myeloma10.3
34hypoxia10.3
35acquired cutis laxa10.3
36indolent myeloma10.2
37osteonecrosis10.2
38arthritis10.2
39osteosclerosis10.2
40prostatitis10.2
41macroglossia10.2
42osteonecrosis of the jaw10.2
43subcorneal pustular dermatosis10.2
44acute leukemia10.2
45scleredema10.2
46gaucher's disease10.2
47monoclonal gammopathy of uncertain significance10.2
48keratopathy10.2
49myeloid leukemia10.2
50essential thrombocythemia10.2

Graphical network of the top 20 diseases related to Myeloma:



Diseases related to myeloma

Symptoms for Myeloma

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Drugs & Therapeutics for Myeloma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Myeloma

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Anatomical Context for Myeloma

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33MalaCards
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MalaCards organs/tissues related to Myeloma:

33
Bone, Bone marrow, B cells, Endothelial, T cells, Kidney, Lung, Skin, Testis, Monocytes, Myeloid, Prostate, Nk cells, Breast, Testes, Liver, Pituitary, Heart, Thyroid, Whole blood, Spinal cord, Colon, Tongue, Pancreas, Lymph node, Brain, Ovary, Skeletal muscle

Animal Models for Myeloma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Myeloma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8FGFR3, IL6R, CCND1, STAT5A, IRF4
2MP:00028739.4IL6R, DAZAP2, LECT1, ADAM9, STAT5A, CCND1
3MP:00053768.9FGFR3, LECT1, NBEA, RASD1, PDZK1, IL6R

Publications for Myeloma

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52PubMed
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Articles related to Myeloma:

(show top 50)    (show all 3932)
idTitleAuthorsYear
1
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
2013
2
An old drug with a new future: bendamustine in multiple myeloma. (24053161)
2013
3
Cytogenetic classification in Korean multiple myeloma patients: Prognostic significance of hyperdiploidy with 47 to 50 chromosomes and the number of structural abnormalities. (24372944)
2013
4
How to determine bortezomib-based regimen for elderly patients with multiple myeloma: PAD versus CBd, an observational study. (24337419)
2013
5
Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma. (23758184)
2013
6
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (22792345)
2012
7
Effects of short-hairpin RNA-inhibited I^-catenin expression on the growth of human multiple myeloma cells in vitro and in vivo. (22609776)
2012
8
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. (21420464)
2011
9
Targeting integrin-linked kinase increases apoptosis and decreases invasion of myeloma cell lines and inhibits IL-6 and VEGF secretion from BMSCs. (20625942)
2011
10
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
2010
11
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
12
Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (19762082)
2010
13
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. (20920357)
2010
14
Potentiation of (-)-epigallocatechin-3-gallate-induced apoptosis by bortezomib in multiple myeloma cells. (20011976)
2009
15
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling. (19755988)
2009
16
MDR1 diplotypes as prognostic markers in multiple myeloma. (18408561)
2008
17
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
18
Detection and quantification of functionally defined hematopoietic progenitor cells and tissue specific mRNA within the peripheral blood of myeloma patients after administration of granulocyte colony-stimulating factor and erythropoietin. (18028434)
2008
19
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. (18182077)
2008
20
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth. (17545613)
2007
21
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. (17640854)
2007
22
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth. (17173546)
2007
23
Heterogeneous expression of CD32 and CD32-mediated growth suppression in human myeloma cells. (16818279)
2006
24
Chemokines in multiple myeloma. (16982321)
2006
25
The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (17043023)
2006
26
Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells. (16396777)
2006
27
Differential expression of vascular endothelial growth factors and their receptors in multiple myeloma. (16870555)
2006
28
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. (15902294)
2005
29
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
2005
30
CIDP and isolated osteosclerotic myeloma. (15623724)
2004
31
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma. (15629043)
2004
32
Advances in biology and therapy of multiple myeloma. (14633785)
2003
33
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
2000
34
CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. (9823960)
1998
35
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
1998
36
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma. (9373192)
1997
37
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
1997
38
Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone. (8977259)
1996
39
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
40
Interferon-gamma in multiple myeloma. (8535185)
1995
41
Optimal blood stem cell mobilization using 10 micrograms/kg granulocyte colony-stimulating factor (G-CSF) alone for high-dose melphalan intensification in multiple myeloma: an intrapatient controlled study. (7522395)
1994
42
Objective response of multiple myeloma to cyclosporin A. (7696923)
1994
43
Potential use of IgA protease therapy in IgA myeloma patients. (8502191)
1993
44
Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. (1391937)
1992
45
Myeloma phenotype: clues to disease origin and manifestation. (1582972)
1992
46
In vitro growth pattern of myeloma cells in liquid suspension or semi-solid culture containing interleukin-6. (1954351)
1991
47
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. (2031968)
1991
48
Analysis of methylation in the c-MYC gene in five human myeloma cell lines. (2004018)
1991
49
Chronic neutrophilic leukemia and myeloma. Report on long survival. (6585081)
1984
50
Panhypopituitarism due to multiple myeloma. (5415797)
1970

Variations for Myeloma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Myeloma:

1
id Gene Name Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564

Expression for genes affiliated with Myeloma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloma

Search GEO for disease gene expression data for Myeloma.

Pathways for genes affiliated with Myeloma

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50PathCards, 60Thomson Reuters, 5Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Myeloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IRF4, STAT5A
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
10.2CCND1, STAT5A
310.2CCND1, STAT5A
410.2CCND1, STAT5A
5
Show member pathways
Type III interferon signaling38
10.1IL6R, CCND1, STAT5A

Compounds for genes affiliated with Myeloma

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pd 17307445 6111.2FGFR3, CCND1
2thalidomide45 51 61 1113.0CCND1, DKK1, IL6R, FGFR3
3progesterone45 29 61 24 1113.9IL6R, CCND1, STAT5A, DKK1
4imatinib45 51 1111.8STAT5A, CCND1, FGFR3
5vegf459.7FGFR3, LECT1, STAT5A, CCND1, IL6R

GO Terms for genes affiliated with Myeloma

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16Gene Ontology
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Cellular components related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00998610.0FGFR3, IL6R, MICA, ADAM9

Biological processes related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:04508610.2IRF4, STAT5A
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.1IL6R, FGFR3
3negative regulation of transcription from RNA polymerase II promoterGO:00012210.0DKK1, CCND1, WHSC1, FGFR3
4JAK-STAT cascadeGO:0072599.9STAT5A, FGFR3

Molecular functions related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.7FGFR3, C1orf35, FCRL4, IRF4, ADAM9, DKK1

Products for genes affiliated with Myeloma

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Myeloma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet