MCID: MYL007
MIFTS: 59

Myeloma malady

Summaries for Myeloma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.

MalaCards: Myeloma, also known as multiple myeloma, is related to multiple myeloma and hodgkin's lymphoma. An important gene associated with Myeloma is WHSC1 (Wolf-Hirschhorn syndrome candidate 1), and among its related pathways are IL6-mediated signaling events and Immune response Oncostatin M signaling via JAK-Stat in human cells. The drugs carmustine and cisplatin and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotype normal.

Wikipedia:63 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

Aliases & Classifications for Myeloma

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60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek
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Aliases & Descriptions:

myeloma 8 10 44
multiple myeloma 60


External Ids:

Disease Ontology8 DOID:0070004

Related Diseases for Myeloma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myeloma:



Diseases related to myeloma

Clinical Features for Myeloma

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Drugs & Therapeutics for Myeloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Myeloma

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Anatomical Context for Myeloma

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32MalaCards
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MalaCards organs/tissues related to Myeloma:

32
Bone, Bone marrow, B cells, Endothelial, T cells, Kidney, Lung, Skin, Testis, Myeloid, Monocytes, Prostate, Nk cells, Breast, Testes, Liver, Pituitary, Heart, Thyroid, Whole blood, Spinal cord, Colon, Pancreas, Lymph node, Tongue, Skeletal muscle, Ovary, Brain

Animal Models for Myeloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287312.3ADAM9, LECT1, DAZAP2, IL6R, FGFR3, MCL1

Publications for Myeloma

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50PubMed
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Articles related to Myeloma:

(show top 50)    (show all 3972)
idTitleAuthorsYear
1
Rapid-onset flaccid paraplegia caused by multiple myeloma dumbbell tumour. (24390704)
2014
2
Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway. (24025590)
2013
3
Multiple myeloma with diffuse osteosclerosis: Distinct from POEMS syndrome. (23890791)
2013
4
Microvesicles secreted from human multiple myeloma cells promote angiogenesis. (24374814)
2013
5
Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. (23902483)
2013
6
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. (23968501)
2013
7
From clinical trials to clinical practice: single-agent carfilzomib adverse events and their management in patients with relapsed and/or refractory multiple myeloma. (24319571)
2013
8
Allogeneic hematopoietic stem cell transplantation for multiple myeloma: what place, if any? (24146203)
2013
9
Nestin expression throughout multistep pathogenesis of multiple myeloma. (24329895)
2013
10
Perioperative Considerations in the Management of a Patient with Multiple Myeloma Undergoing Aortic Valve Replacement. (24325955)
2013
11
Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells. (22819074)
2012
12
Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation. (22427205)
2012
13
Pegylated liposomal doxorubicin: a review of its use in metastatic breast cancer, ovarian cancer, multiple myeloma and AIDS-related Kaposi's sarcoma. (22141391)
2011
14
Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets. (20721556)
2011
15
Comparison among immunologically different subtypes of 595 untreated multiple myeloma patients in northern China. (20511165)
2010
16
IgA orbital plasmacytoma in multiple myeloma. (20305517)
2010
17
Impedance cardiography in the diagnosis of capillary leak syndrome caused by doxorubicin therapy in a patient with myeloma multiplex. (20104463)
2010
18
Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. (20595817)
2010
19
Constitutively lower expressions of CD54 on primary myeloma cells and their different localizations in bone marrow. (19500134)
2009
20
Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease. (19181642)
2009
21
Expression of vascular cell adhesion molecule-1 in patients with multiple myeloma and its significance]. (19379571)
2009
22
Multiple myeloma presenting as cervical lymphadenopathy in a 16-year-old boy. (19715046)
2009
23
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity. (18172012)
2008
24
Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells. (18813856)
2008
25
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis. (18594024)
2008
26
Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. (17136320)
2007
27
OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. (17699852)
2007
28
Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma. (15512823)
2004
29
Bone marrow microvascular density and angiogenic growth factors in multiple myeloma. (15552270)
2004
30
Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. (12707028)
2003
31
Immunoglobulin A multiple myeloma presenting with Henoch-SchAPnlein purpura associated with reduced sialylation of IgA1. (12956761)
2003
32
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. (14500688)
2003
33
Occurrence of dysregulated oncogenes in primary plasma cells representing consecutive stages of myeloma pathogenesis: indications for different disease entities. (14531906)
2003
34
Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. (12786795)
2003
35
Cell cycle regulators in multiple myeloma: prognostic implications of p53 nuclear accumulation. (12605365)
2003
36
RANK (receptor activator of nuclear factor-kappaB) and RANKL expression in multiple myeloma. (11918537)
2002
37
Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells. (10929035)
2000
38
High-dose therapy in multiple myeloma: effect of positive selection of CD34+ peripheral blood stem cells on hematologic engraftment and clinical outcome. (10702815)
2000
39
Pyomyositis associated with Bacteroides fragilis in a patient with multiple myeloma. (9684625)
1998
40
Profound hypophosphatemia and isolated hyperphosphaturia in two cases of multiple myeloma. (9041222)
1997
41
Soluble interleukin-6 receptors in the serum in multiple myeloma]. (8998823)
1996
42
Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein. (8822942)
1996
43
The prognostic significance of the beta 2-microglobulin level of the blood serum in multiple myeloma patients]. (9026938)
1996
44
Cell surface expression and functional significance of adhesion molecules on human myeloma-derived cell lines. (7993788)
1994
45
Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. (7919347)
1994
46
Urinary N-acetyl-beta-D-glucosaminidase and gamma-glutamyl-transpeptidase activities for evaluation of renal disturbance in patients with multiple myeloma]. (1363243)
1992
47
Increased expression of the c-myc gene may be related to the aggressive transformation of human myeloma cells. (2025578)
1991
48
Myeloma colony growth and patient status: colony growth in plasma cell leukemia and suppressive effect of leukemic cells. (6741428)
1984
49
Concurrent pityriasis rotunda and acquired ichthyosis with IgG myeloma. (4433476)
1974
50
Multiple myeloma and pernicious anemia, (case report). (5262861)
1970

Genetic Variations for Myeloma

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Expression for genes affiliated with Myeloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloma

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Pathways for genes affiliated with Myeloma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Myeloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2IL6R, MCL1, TNFSF11
2
Immune response Oncostatin M signaling via JAK-Stat in human cells
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11.0IL6R, STAT5A

Compounds for genes affiliated with Myeloma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1115.1RASD1, IL6R, FGFR3, MCL1, STAT5A, TNFSF11
2vegf4412.0TNFSF11, STAT5A, MCL1, FGFR3, IL6R, LECT1
3lipid4412.0STAT5A, MCL1, FGFR3, IL6R, LECT1, TNFSF11
4thalidomide44 49 59 1114.1DKK1, FGFR3, IL6R
5gp 1304410.9IL6R, STAT5A, TNFSF11

GO Terms for genes affiliated with Myeloma

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16Gene Ontology
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Biological processes related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monocyte chemotaxisGO:00254811.0IL6R, TNFSF11
2positive regulation of interleukin-2 biosynthetic processGO:04508610.7STAT5A, IRF4

Molecular functions related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.6WHSC1, PDZK1, IRF4, STAT5A, DKK1, MCL1

Products for genes affiliated with Myeloma

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Sources for Myeloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet