MCID: MYL007
MIFTS: 53

Myeloma malady

Summaries for Myeloma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.

MalaCards: Myeloma, also known as multiple myeloma, is related to hypercalcemia and arthritis. An important gene associated with Myeloma is WHSC1 (Wolf-Hirschhorn syndrome candidate 1), and among its related pathways are IL6-mediated signaling events and Immune response Oncostatin M signaling via JAK-Stat in human cells. The drugs carmustine and cisplatin and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Related mouse phenotype normal.

Wikipedia:64 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

Aliases & Classifications for Myeloma

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek
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Aliases & Descriptions:

myeloma 8 10 45
multiple myeloma 61


External Ids:

Disease Ontology8 DOID:0070004

Related Diseases for Myeloma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the multiple myeloma family:

myeloma familial myeloma

Diseases related to Myeloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia30.4IL6R, TNFSF11
2arthritis30.3IL6R, TNFSF11
3b-cell lymphomas30.0TNFSF11, IRF4, STAT5A, MCL1
4adenoma30.0IL6R, MCL1, STAT5A
5amyloidosis10.7
6plasma cell leukemia10.6
7smoldering myeloma10.6
8osteosclerotic myeloma10.6
9extramedullary plasmacytoma10.5
10hematopoietic stem cell transplantation10.5
11acute leukemia10.5
12macroglobulinemia10.5
13poems syndrome10.4
14t-cell leukemia10.4
15fanconi syndrome10.4
16light chain deposition disease10.4
17indolent myeloma10.3
18adult syndrome10.3
19cutis laxa10.3
20familial myeloma10.3
21cryoglobulinemia10.3
22mu chain disease10.3
23waldenstrom macroglobulinemia10.3
24acquired cutis laxa10.3
25hypoxia10.3
26subcorneal pustular dermatosis10.2
27osteonecrosis10.2
28macroglossia10.2
29n syndrome10.2
30scleredema10.2
31hepatitis c10.2
32herpes zoster10.2
33essential thrombocythemia10.2
34necrobiotic xanthogranuloma10.2
35peripheral t-cell lymphoma10.2
36graft versus host disease10.1
37bone lymphoma10.1
38xanthomatosis10.1
39acute myelomonocytic leukemia10.1
40amyloid neuropathy10.1
41acute myeloid leukemia10.1
42stevens-johnson syndrome10.1
43thrombotic thrombocytopenic purpura10.1
44pyoderma gangrenosum10.1
45pyomyositis10.1
46mantle cell lymphoma10.1
47arthropathy10.1
48bone development disease10.1
49vasculitis10.1
50chronic neutrophilic leukemia10.1

Graphical network of the top 20 diseases related to Myeloma:



Diseases related to myeloma

Clinical Features for Myeloma

Drugs & Therapeutics for Myeloma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Myeloma

Anatomical Context for Myeloma

Animal Models for Myeloma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Myeloma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287312.3ADAM9, LECT1, DAZAP2, IL6R, FGFR3, MCL1

Publications for Myeloma

Sources:
51PubMed
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Articles related to Myeloma:

(show top 50)    (show all 4000)
idTitleAuthorsYear
1
Rapid-onset flaccid paraplegia caused by multiple myeloma dumbbell tumour. (24390704)
2014
2
Cytogenetic and clinical risk factors for assessment of ultra high-risk multiple myeloma. (24342807)
2014
3
Time-to-diagnosis and symptoms of myeloma, lymphomas and leukaemias: a report from the Haematological Malignancy Research Network. (24238148)
2013
4
Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. (23902483)
2013
5
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. (23968501)
2013
6
From clinical trials to clinical practice: single-agent carfilzomib adverse events and their management in patients with relapsed and/or refractory multiple myeloma. (24319571)
2013
7
Allogeneic hematopoietic stem cell transplantation for multiple myeloma: what place, if any? (24146203)
2013
8
Unusual milia amyloidosis as initial signs of multiple myeloma-associated systemic amyloidosis. (23869927)
2013
9
A rare cause of gastrointestinal bleeding. Multiple myeloma with extramedullary gastroduodenal plasmacytoma. (23900105)
2013
10
Brain abscess caused by Nocardia cyriacigeorgica in two patients with multiple myeloma: novel agents, new spectrum of infections. (23906027)
2013
11
Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells. (24126540)
2013
12
Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets. (20721556)
2011
13
Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma. (21660045)
2011
14
Impedance cardiography in the diagnosis of capillary leak syndrome caused by doxorubicin therapy in a patient with myeloma multiplex. (20104463)
2010
15
Recurrent multiple myeloma presenting as a breast plasmacytoma. (21939175)
2010
16
Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. (20621094)
2010
17
Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. (19016584)
2009
18
Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1alpha. (18774952)
2008
19
Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line]. (17708799)
2007
20
From the bench to the bedside: emerging new treatments in multiple myeloma. (18070720)
2007
21
Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. (16497971)
2006
22
IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3. (16188230)
2005
23
The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation. (15761016)
2005
24
Angiopoietin-1 and myeloma-induced angiogenesis. (15621778)
2005
25
Randomized comparison of granulocyte colony-stimulating factor versus granulocyte-macrophage colony-stimulating factor plus intensive chemotherapy for peripheral blood stem cell mobilization and autologous transplantation in multiple myeloma. (15148493)
2004
26
Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma. (15512823)
2004
27
A VEGF-dependent autocrine loop mediates proliferation and capillarogenesis in bone marrow endothelial cells of patients with multiple myeloma. (15583754)
2004
28
IL-6-independent expression of Mcl-1 in human multiple myeloma. (12660820)
2003
29
Immunoglobulin A multiple myeloma presenting with Henoch-SchAPnlein purpura associated with reduced sialylation of IgA1. (12956761)
2003
30
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. (14500688)
2003
31
Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. (14679006)
2003
32
Role of cytogenetics in the prognosis of patients with multiple myeloma]. (14699690)
2003
33
RANK (receptor activator of nuclear factor-kappaB) and RANKL expression in multiple myeloma. (11918537)
2002
34
Molecular sequelae of proteasome inhibition in human multiple myeloma cells. (12391322)
2002
35
Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor. (12393395)
2002
36
Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. (11369623)
2001
37
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. (11562486)
2001
38
Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells. (10929035)
2000
39
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. (9490667)
1998
40
Multiple myeloma: new aspects of biology and treatment. (9597800)
1998
41
Collection, tumor contamination, and engraftment kinetics of highly purified hematopoietic progenitor cells to support high dose therapy in multiple myeloma. (9616143)
1998
42
Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein. (8822942)
1996
43
A new staging system for multiple myeloma based on the number of S-phase plasma cells. (7811998)
1995
44
Subcorneal pustular dermatosis at the injection site of recombinant human granulocyte-macrophage colony-stimulating factor in a patient with IgA myeloma. (8176021)
1994
45
Production of fibronectin and adherence to fibronectin by human myeloma cell lines. (7947265)
1994
46
Prognostic factors in multiple myeloma. Review of the literature]. (8081040)
1993
47
Increased expression of the c-myc gene may be related to the aggressive transformation of human myeloma cells. (2025578)
1991
48
Hypocomplementemic proliferative glomerulonephritis with C3 nephritic-factor-like activity in multiple myeloma. (2662048)
1989
49
Acquired cutis laxa associated with multiple myeloma. (942220)
1976
50
Multilocular myelomalacia following adhesive arachnoiditis. (13348822)
1956

Genetic Variations for Myeloma

Expression for genes affiliated with Myeloma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloma

Search GEO for disease gene expression data for Myeloma.

Pathways for genes affiliated with Myeloma

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
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Pathways related to Myeloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2IL6R, MCL1, TNFSF11
2
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
11.0IL6R, STAT5A

Compounds for genes affiliated with Myeloma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
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Compounds related to Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1115.1IL6R, TNFSF11, STAT5A, MCL1, FGFR3, RASD1
2vegf4512.0LECT1, TNFSF11, STAT5A, MCL1, FGFR3, IL6R
3lipid4512.0IL6R, FGFR3, TNFSF11, STAT5A, MCL1, LECT1
4thalidomide45 50 60 1114.1FGFR3, IL6R, DKK1
5gp 1304510.9STAT5A, TNFSF11, IL6R

GO Terms for genes affiliated with Myeloma

Sources:
16Gene Ontology
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Biological processes related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monocyte chemotaxisGO:00254811.0IL6R, TNFSF11
2positive regulation of interleukin-2 biosynthetic processGO:04508610.7STAT5A, IRF4

Molecular functions related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.6WHSC1, PDZK1, IRF4, STAT5A, DKK1, MCL1

Products for genes affiliated with Myeloma

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Myeloma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet