MCID: MYL007
MIFTS: 59

Myeloma malady

Summaries for Myeloma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.

MalaCards: Myeloma, also known as multiple myeloma, is related to multiple myeloma and hodgkin's lymphoma. An important gene associated with Myeloma is WHSC1 (Wolf-Hirschhorn syndrome candidate 1), and among its related pathways are IL6-mediated signaling events and Immune response Oncostatin M signaling via JAK-Stat in human cells. The drugs carmustine and cisplatin and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotype normal.

Wikipedia:63 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

Aliases & Classifications for Myeloma

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60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek
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Aliases & Descriptions:

myeloma 8 10 44
multiple myeloma 60


External Ids:

Disease Ontology8 DOID:0070004

Related Diseases for Myeloma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myeloma:



Diseases related to myeloma

Clinical Features for Myeloma

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Drugs & Therapeutics for Myeloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Myeloma

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Anatomical Context for Myeloma

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32MalaCards
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MalaCards organs/tissues related to Myeloma:

32
Bone, Bone marrow, B cells, Endothelial, T cells, Kidney, Lung, Testis, Skin, Myeloid, Monocytes, Nk cells, Prostate, Breast, Testes, Liver, Pituitary, Heart, Thyroid, Whole blood, Spinal cord, Colon, Pancreas, Tongue, Lymph node, Brain, Ovary, Skeletal muscle

Animal Models for Myeloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myeloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287312.3ADAM9, LECT1, DAZAP2, IL6R, FGFR3, MCL1

Publications for Myeloma

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50PubMed
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Articles related to Myeloma:

(show top 50)    (show all 3972)
idTitleAuthorsYear
1
Replacement of bortezomib with carfilzomib for multiple myeloma patients progressing from bortezomib combination therapy. (24429497)
2014
2
Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma. (23671753)
2013
3
BAFF and APRIL as TNF superfamily molecules and angiogenesis parallel progression of human multiple myeloma. (24141333)
2013
4
Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma. (24248686)
2013
5
Trends in utilization and outcomes of autologous transplantation as early therapy for multiple myeloma. (23939198)
2013
6
Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation: a report from the French Society of Bone Marrow and Cellular Therapy. (23144198)
2013
7
Tubular nuclear accumulation of Snail and epithelial phenotypic changes in human myeloma cast nephropathy. (21315411)
2011
8
Integrin I^7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. (21474670)
2011
9
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
2010
10
Detecting methylation patterns of p16, MGMT, DAPK and E-cadherin genes in multiple myeloma patients. (19302404)
2010
11
Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. (19914305)
2010
12
Short or long survival in multiple myeloma. A simple method for determining the prognosis. (19052918)
2009
13
CD117 (c-kit) is aberrantly expressed in a subset of MGUS and multiple myeloma with unexpectedly good prognosis. (17767956)
2008
14
Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report. (18291467)
2008
15
Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism. (18846331)
2008
16
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. (17942756)
2008
17
JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation coexist, but originate from separate clones. (19129688)
2008
18
Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. (16385588)
2006
19
Bone destruction in multiple myeloma. (16831932)
2006
20
Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma. (16193335)
2006
21
New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway. (16454747)
2006
22
The significance of IGF-1, VEGF, IL-6 in multiple myeloma progression]. (16875552)
2006
23
Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival. (15638855)
2005
24
Immunomodulation of multiple myeloma. (15640623)
2004
25
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells. (15491288)
2004
26
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. (15070700)
2004
27
Burkholderia cenocepacia vaginal infection in patient with smoldering myeloma and chronic hepatitis C. (15550207)
2004
28
New insights into the pathophysiology of multiple myeloma. (12965277)
2003
29
Fibrinolytic activity in multiple myeloma. (14635202)
2003
30
Expression of parathyroid hormone-related protein (PTHrP) in multiple myeloma. (11940209)
2002
31
Enhanced antitumoral effectiveness of idiotype vaccination induced by the administration of Flt3 ligand combined with interleukin 2 against a murine myeloma. (11918538)
2002
32
Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. (11468182)
2001
33
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis. (11524732)
2001
34
Interleukin-10 gene promoter polymorphisms in multiple myeloma. (11307152)
2001
35
Smoldering, asymptomatic stage 1, and indolent myeloma. (12057049)
2000
36
Interferon in multiple myeloma--summary of treatment results and clinical implications. (11145439)
2000
37
CD9 expression enhances the susceptibility of myeloma cell lines to cell-mediated cytolysis. (10891455)
2000
38
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
1998
39
Taxol can induce phosphorylation of BCL-2 in multiple myeloma cells and potentiate dexamethasone-induced apoptosis. (9619919)
1998
40
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
1997
41
Serum oncostatin M in multiple myeloma: association with prognostic factors. (9012701)
1997
42
Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. (8695815)
1996
43
Whole blood harvested after granulocyte-colony stimulating factor (Neupogen) mobilization, and reinfused unprocessed after high-dose melphalan treatment, accelerates hematopoietic recovery in patients with multiple myeloma. (8635126)
1996
44
Interferon-alpha-2b with VMCP for induction in multiple myeloma: the Israel Myeloma Cooperative Group experience. (7591683)
1995
45
The role of interferon-alpha in the treatment of multiple myeloma]. (7699901)
1995
46
Alternating combination chemotherapy and interferon improves survival in poor prognosis multiple myeloma. (7542473)
1995
47
Plasma prekallikrein, coagulation and fibrinolytic parameters in myeloma patients. (1502028)
1992
48
Rapid disappearance of M-protein in multiple myeloma complicated by pneumonia during treatment with HLBI]. (1479692)
1992
49
DDAVP in acquired von Willebrand syndrome associated with multiple myeloma. (3088986)
1986
50
Localized and indolent myeloma. (7407416)
1980

Genetic Variations for Myeloma

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Expression for genes affiliated with Myeloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloma

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Pathways for genes affiliated with Myeloma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Myeloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2IL6R, MCL1, TNFSF11
2
Immune response Oncostatin M signaling via JAK-Stat in human cells
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11.0IL6R, STAT5A

Compounds for genes affiliated with Myeloma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1115.1IL6R, TNFSF11, STAT5A, MCL1, FGFR3, RASD1
2vegf4412.0LECT1, TNFSF11, STAT5A, MCL1, FGFR3, IL6R
3lipid4412.0IL6R, FGFR3, TNFSF11, STAT5A, MCL1, LECT1
4thalidomide44 49 59 1114.1FGFR3, IL6R, DKK1
5gp 1304410.9STAT5A, TNFSF11, IL6R

GO Terms for genes affiliated with Myeloma

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16Gene Ontology
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Biological processes related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monocyte chemotaxisGO:00254811.0IL6R, TNFSF11
2positive regulation of interleukin-2 biosynthetic processGO:04508610.7STAT5A, IRF4

Molecular functions related to Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.6WHSC1, PDZK1, IRF4, STAT5A, DKK1, MCL1

Products for genes affiliated with Myeloma

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Sources for Myeloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet