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Myeloma malady
27 drugs, 1034 genes, 25 tissues, 828 related diseases, 29 phenotypes, 2283 articles, clinical trials.

Summaries for Myeloma

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Disease Ontology: A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.6

MalaCards: Myeloma, also known as multiple myeloma, is related to carcinoma and leukemia. An important gene associated with Myeloma is IRF4 (interferon regulatory factor 4), and among its related pathways are STAT3 Pathway and Pathways in cancer. The drugs carmustine and cisplatin and the compounds serine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are cellular and homeostasis/metabolism.

Wikipedia: Multiple myeloma (from Greek myelo-, bone marrow), also known as plasma cell myeloma or Kahler\'s...44 more...

Aliases & Descriptions for Myeloma

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43UMLS, 6Disease Ontology, 8DISEASES, 32Novoseek
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myeloma 6 8 32
multiple myeloma 43

Related Diseases for Myeloma

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13GeneCards, 14GeneDecks
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Diseases related to myeloma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 825)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma163.5PIM2, PIK3CA, PIAS3, PIK3R2, PIK3R1, PIK3CG
2leukemia162.4PIM2, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
3prostatitis138.1PIM2, PIK3CA, PIAS3, PIK3R2, PIK3R1, PIK3CG
4thyroiditis108.2PIK3CA, PIK3R1, PIK3CG, LRP1, LRP2, NCAM1
5myeloid leukemia106.5PIM2, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP5
6lymphocytic leukemia105.9PIM2, PIK3CA, PIK3CG, NCAM1, PDE4A, RECK
7colon cancer98.8PIK3CA, PIK3R1, PIK3CG, LRP6, NCAM1, NCOR2
8cervicitis98.5PIK3CA, PIK3CG, NCR1, NCR2, PDE4A, RECK
9breast carcinoma98.4PIK3CA, PIK3R1, PIK3CG, LRP1, RECK, CNTN2
10hypoxia96.5PIK3CA, PIK3R1, PIK3CG, LRP1, LRP5, PDE4A
11sarcoma95.7PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1, PDE4A
12acute myeloid leukemia88.6PIM2, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP5
13adenoma80.3PIK3CA, NCAM1, NCOR2, PDE4A, RECK, CNTF
14anemia78.7NCAM1, RELA, SGK1, KIT, KITLG, VWF
15melanoma78.5PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, NCAM1
16acute leukemia77.8PIK3CA, NCAM1, NCOR2, KIT, KITLG, VWF
17pancreatitis77.3PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, LRP2
18squamous cell carcinoma76.3PIK3CA, RECK, RELA, VTN, PCNA, RB1
19adenocarcinoma74.4PIM2, PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1
20arthritis73.9PIK3CG, LRP1, LRP2, LRP5, PDCD5, PDE4A
21nephropathy73.8LRP1, LRP2, RELA, SGK1, KITLG, VWF
22neuronitis73.5PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, LRP2
23hepatocellular carcinoma73.4PIM2, PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK
24rheumatoid arthritis69.8PIK3CG, LRP1, LRP2, LRP5, PDCD5, PDE4A
25retinoblastoma69.2PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK, KIT
26diffuse large b-cell lymphoma68.6PIK3CA, PIK3CG, NCAM1, PDE4A, REL, RELA
27gastric cancer66.1PIK3CA, PIK3R1, PIK3CG, RECK, RELA, WARS
28pneumonia64.5PDE4A, RELA, VTN, RBP4, SELL, SERPINC1
29gonococcal synovitis63.3PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1, PDE4A
30non-hodgkin lymphoma62.7NCOR2, KITLG, SELL, NAT1, NAT2, VDR
31hematopoiesis59.1PIK3R1, PIK3CG, KIT, KITLG, PCNA, RB1
32neuroblastoma58.6PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1, NCOR2
33leukemia/lymphoma57.5PIM2, PIK3CA, PIK3CG, REL, CNTN2, KITLG
34esophagitis57.0PIK3CA, PIK3CG, NCAM1, PDCD5, PDE4A, RECK
35b-cell lymphomas56.8REL, RB1, MYC, BMI1, BLZF1, BIK
36mantle cell lymphoma56.7PIM2, PIK3CA, PIK3CG, KIT, SFRP1, RB1
37chronic lymphocytic leukemia55.7PDE4A, REL, SELL, BLZF1, BIRC2, BIRC3
38liver cancer55.6PIK3CG, SFRP2, RB1, SETD2, NAT1, NAT2
39lymphoblastic leukemia54.8PIK3CA, PIK3CG, LRP5, NCAM1, RECK, RELA
40fibrosis53.8PIK3CA, PIAS3, PIK3CG, LRP1, PDE4A, RECK
41measles53.7PIK3CA, PIK3R2, PIK3R1, PIK3CG, RECK, RELA
42t-cell leukemia53.7PIK3CG, REL, RELA, CNTN2, VAV1, MYC
43hodgkin's lymphoma53.1PIK3R1, PIK3CG, REL, SELP, BMI1, RAG2
44asthma52.4PIK3CA, PIK3R1, PIK3CG, LRP1, PDE4A, RECK
45immunodeficiency52.3SELL, MYD88, BMP6, BLZF1, PARP1, BCR
46thrombosis52.3PIK3CG, LRP1, RECK, VWF, VTN, PCNA
47lupus erythematosus51.7PIK3CG, LRP2, RECK, REL, CNTF, KIR3DS1
48alzheimer's disease50.4PIK3CA, PIK3R1, PIK3CG, LRP1, LRP2, LRP6
49neuropathy50.3NCAM1, PDE4A, CNTF, CNTFR, VWF, NAGLU
50ovarian carcinoma49.9PIK3CA, PIK3CG, PDCD5, RECK, REL, RELA

Graphical network of the top 20 diseases related to myeloma:



Graphical network of diseases related to myeloma

Clinical Features for Myeloma

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Drugs & Therapeutics for Myeloma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 aldesleukin, bortezomib, carmustine, cisplatin, cisplatin pwdr [va product], cyclophosphamide, doxorubicin hydrochloride, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, melphalan, melphalan hydrochloride, peginterferon alfa-2a, peginterferon alfa-2b, procarbazine, procarbazine hydrochloride, thalidomide, zoledronic, zoledronic acid

Genetic Tests for Myeloma

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Anatomical Context for Myeloma

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22MalaCards
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MalaCards organs/tissues related to myeloma:

22
Bone marrow, Whole blood, Lymph node, Brain, Heart, Skeletal muscle, Colon, Kidney, Liver, Lung, Thyroid, Breast, Skin, Ovary, Prostate, Testis, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pituitary, Testis germ

Phenotypes for genes affiliated with Myeloma

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25MGI
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MGI Mouse Phenotypes related to myeloma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:000538465.9PIM2, PIK3CA, PIK3R1, PIK3CG, LRP2, LRP5
2homeostasis/metabolism phenotypeMP:000537662.8PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, LRP2
3mortality/agingMP:001076852.0PIK3CA, LRP1, LRP5, LRP6, NCAM1, NCOR2
4cardiovascular system phenotypeMP:000538548.4PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, LRP5
5growth/size phenotypeMP:000537848.1PIM2, PIK3CA, PIK3R1, PIK3CG, LRP1, LRP2
6hematopoietic system phenotypeMP:000539741.1PIM2, NCR1, CNTF, KIT, SFRP1, PCNA
7nervous system phenotypeMP:000363138.6LRP1, LRP5, LRP6, PDE4A, RECK, REL
8behavior/neurological phenotypeMP:000538635.3PIK3CA, LRP1, LRP2, LRP5, LRP6, NCAM1
9normal phenotypeMP:000287334.5PIK3R1, LRP1, LRP5, LRP6, NCR1, RELA
10tumorigenesisMP:000200633.6PIK3CA, PIK3R2, PIK3R1, KIT, KITLG, RB1
11integument phenotypeMP:001077132.7PIK3CG, LRP6, RECK, REL, RELA, RELB
12skeleton phenotypeMP:000539031.5PIK3CG, LRP1, LRP2, LRP6, RECK, REL
13muscle phenotypeMP:000536931.2PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, RELA
14vision/eye phenotypeMP:000539130.6PIK3CA, LRP2, LRP5, LRP6, NCAM1, RELA
15digestive/alimentary phenotypeMP:000538127.2LRP2, LRP6, NCOR2, REL, RELB, KIT
16reproductive system phenotypeMP:000538925.8PIK3CA, LRP6, KIF11, SFRP2, SFRP4, SFRP5
17embryogenesis phenotypeMP:000538025.1PIK3CA, LRP5, LRP6, RECK, REL, KIT
18renal/urinary system phenotypeMP:000536723.3LRP2, LRP6, SGK1, KIT, SFRP4, SELP
19limbs/digits/tail phenotypeMP:000537121.6LRP5, LRP6, RECK, RELA, RELB, KIT
20liver/biliary system phenotypeMP:000537021.5LRP5, LRP6, NCOR2, RECK, REL, RELB
21adipose tissue phenotypeMP:000537519.6PIK3CA, PIK3R1, LRP1, LRP6, NCOR2, SFRP1
22craniofacial phenotypeMP:000538219.0LRP2, LRP5, LRP6, NCOR2, KIT, KITLG
23hearing/vestibular/ear phenotypeMP:000537717.4LRP2, LRP6, KIT, KITLG, RB1, NAGLU
24respiratory system phenotypeMP:000538816.8LRP2, LRP6, REL, RELB, SFRP4, NBEA
25endocrine/exocrine gland phenotypeMP:000537916.3LRP2, LRP5, RELB, SFRP2, SFRP5, SELL
26other phenotypeMP:000539514.8RECK, RELB, RARA, RARB, KDR, JAK2
27pigmentation phenotypeMP:000118614.6LRP5, KIT, KITLG, RB1, SERPINC1, NAGLU
28immune system phenotypeMP:0005387INFPIM2, LRP1, LRP5, PDE4A, REL, RELB
29no phenotypic analysisMP:0003012INFPIK3R1, LRP2, LRP6, SGK1, SFRP1, SFRP2

Publications for genes affiliated with Myeloma

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35PubMed
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Articles related to myeloma:

(show top 50)    (show all 2283)
idTitleAuthorsYearAffiliating Genes
1HOXB7 expression by myeloma cells regulates their pro -angiogenic properties in multiple myeloma patients. (21183939)Storti P.... Giuliani N.2011HOXB7
2Expression of WT1 gene in multiple myeloma patients a t diagnosis: is WT1 gene expression a useful marker in multiple myeloma? (20132661)Saatci C.... Ozkul Y.2010WT1
3UK Myeloma Forum (UKMF) and Nordic Myeloma Study Grou p (NMSG): guidelines for the investigation of newly detected M-proteins and the management of monoclonal gammopathy of undetermined significance (MGUS). (19673884)Bird J.... Low E.2009MYOM2
4Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. (19067746)Heider U.... Sezer O.2009DKK1
5Induction of myeloma-specific cytotoxic T lymphocytes ex vivo by CD40-activated B cells loaded with myeloma tumor antigens. (19277657)Kim S.K.... Lee J.J.2009TF, IL4
6Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin. (18415656)Kuroda J.... Maekawa T.2008XIAP, MCL1
7Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells. (18512025)ZdzisiA8ska B.... Kandefer-SzerszeA8 M.2008SPP1, IL6, TNFSF13B
8A biased Gm haplotype and Gm paraprotein allotype in multiple myeloma suggests a role for the Gm system in myeloma development. (17373937)Ilic V.... Stefanovic G.2007HLA-B
9The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis. (17848618)Colla S.... Giuliani N.2007SPP1, HIF1A, IL8
10In vitro expansion of gamma delta T cells with anti-myeloma cell activity by Phosphostim and IL-2 in patients with multiple myeloma. (17897296)BurjanadzAc M.... Lu Z.Y.2007IL2
11Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth. (17369488)Chen H.... Berenson J.R.2007PTN
12A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. (16293576)Gunn W.G.... Gregory C.A.2006IL6, DKK1
13Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma. (16732320)Mahtouk K.... Klein B.2006NRG3, NRG2
14Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients. (16900214)De Bruyne E.... Vanderkerken K.2006CD9, TSPAN32
15Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells. (15735670)Mahtouk K.... Klein B.2005AREG
16Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients. (16208410)Colla S.... Giuliani N.2005SPP1, RUNX2
17ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. (16044163)Suzuki A.... Esumi H.2005IGF1, NUAK1
18Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma. (15003892)Standal T.... Hjertner O.2004SPP1
19Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myeloma. (15015966)Hashimoto T.... Matsumoto T.2004CCL4, CCL3, BGLAP
20Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. (14737074)Giuliani N.... Bonati A.2004MAP2K1, MAPK1, IL6
21IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. (14615378)Lee J.W.... Choi S.J.2004IL3
22Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. (11943714)Ely S.A.... Knowles D.M.2002NCAM1
23Evaluation of bone disease in multiple myeloma: a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients. (12367766)Alexandrakis M.G.... Margioris A.N.2002B2M, CD36, BGLAP
24Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. (12393684)Giuliani N.... Rizzoli V.2002TNFSF11
25Sperm protein 17 (Sp17) in multiple myeloma: opportunity for myeloma-specific donor T cell infusion to enhance graft-versus-myeloma effect without increasing graft-versus-host disease risk. (11477539)Chiriva-Internati M.... Lim S.H.2001SPA17
26Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein. (11164109)Butch A.W.... Munshi N.C.2001IL4, CSF2, CD79A
27Myeloma isotype-switch variants in the murine 5T myeloma model: evidence that myeloma IgM and IgA expressing subclones can originate from the IgG expressing tumour. (11455984)Bakkus M.H.... Van Camp B.2001CD79A
28Treatment of multiple myeloma by antibody mediated im munotherapy and induction of myeloma selective antigens. (10707790)Treon S.P.... Anderson K.C.2000IFNG
29Myeloma progenitors in the blood of patients with aggressive or minimal disease: engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice. (10648422)Pilarski L.M.... Belch A.R.2000CSF3
30MPC-1-CD49e- immature myeloma cells include CD45+ subpopulations that can proliferate in response to IL-6 in human myelomas. (10233376)Fujii R.... Kawano M.M.1999IL6
31TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. (10557057)Gazitt Y.1999BCL2, TNFSF10
32Expression of beta 1 integrins (very late antigens-4 and -5) on myeloma cells and clinical correlates in patients with multiple myeloma. (9513075)Nishinarita S.... Horie T.1998ITGA4, ITGB1
33The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. (9531328)Jourdan M.... Klein B.1998ANXA5
34Both myeloma cells and bone marrow stromal cells are involved in the overproduction of interleukin 6 in multiple myeloma (11243111)Ding S.... Sun A.1998IL6
35Australian Leukaemia Study Group myeloma II: a randomized trial of intensive combination chemotherapy with or without interferon in patients with myeloma. (9136940)Joshua D.E.... Goldstein D.1997IFNA2
36Health-related quality of life assessed before and du ring chemotherapy predicts for survival in multiple myeloma. Nordic Myeloma Stu dy Group. (9136939)WislA... Hjorth M.1997IFNA2
37Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of proMMP-2, and induction of MMP-1 by myeloma cells. (9269785)BarillAc S.... Amiot M.1997MMP2, MMP1, OSM
38Serum markers of bone metabolism in multiple myeloma: prognostic value of the carboxy-terminal telopeptide of type I collagen (ICTP). Nordic Myeloma Study Group (NMSG). (9012695)Abildgaard N.... Heickendorff L.1997BGLAP, SIL1
39Measurement of health-related quality of life in mult iple myeloma. Nordic Myeloma Study Group. (8616024)WislA... Westin J.1996IFNA2
40Interferon-alpha 2b added to melphalan-prednisone for initial and maintenance therapy in multiple myeloma. A randomized, controlled trial. The Nordic Myeloma Study Group. (8533996)1996IFNA2
41Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor. (8555506)Gazitt Y.... Tricot G.1996CSF2
42Recombinant human erythropoietin in transfusion-depen dent anemic patients with multiple myeloma and non-Hodgkin's lymphoma--a random ized multicenter study. The European Study Group of Erythropoietin (Epoetin Bet a) Treatment in Multiple Myeloma and Non-Hodgkin's Lymphoma. (8639883)Osterborg A.... Peest D.1996EPO
43Interferon-alpha-2b with VMCP for induction in multiple myeloma: the Israel Myeloma Cooperative Group experience. (7591683)Cohen A.M.... Manor Y.1995IFNA2, IFNA1
44A comparison of polychemotherapy and melphalan/prednisone for primary remission induction, and interferon-alpha for maintenance treatment, in multiple myeloma. A prospective trial of the German Myeloma Treatment Group. (7718318)Peest D.... GAPbel B.1995IFNA1
45Assessment of the therapeutic potential of cytokines, cytotoxic drugs and effector cell populations for the treatment of multiple myeloma using the 5T33 murine myeloma model. (7493769)Manning L.S.... Cordingley F.T.1995IFNA1
46Tumour necrosis factor-alpha and interleukin 4 promote the differentiation of myeloma cell precursors in multiple myeloma. (7803239)Sawamura M.... Tsuchiya J.1994IL4
47Multiple myeloma with massive ascites fluid--immunophenotypic analysis of myeloma cell and its IL-6-dependent growth (7861616)Tatsumi T.... Shimazaki C.1994ICAM1, ITGA4, IL6
48Randomised trial of intravenous immunoglobulin as pro phylaxis against infection in plateau-phase multiple myeloma. The UK Group for Immunoglobulin Replacement Therapy in Multiple Myeloma. (7909099)Chapel H.M.... Prentice A.G.1994ALB
49Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient. (8051415)Takahashi T.... Yachi A.1994MUC1
50Colony stimulating activity in the serum of patients with multiple myeloma is enhanced by interleukin 3: a possible role for interle ukin 3 after high dose melphalan and autologous bone marrow transplantation for multiple myeloma. (2201402)Millar B.C.... McElwain T.J.1990IL3

Expression for genes affiliated with Myeloma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Myeloma

Pathways for genes affiliated with Myeloma

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36QIAGEN, 20KEGG, 41Thomson Reuters, 10EMD Millipore, 3Cell Signaling Technology, 37R&D Systems, 34PharmGKB
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Pathways related to myeloma according to GeneDecks:

(show top 50)    (show all 389)
idPathwayScoreTop Affiliating Genes
1STAT3 Pathway3626.1BRAF, MYC, BMP2, BMP4, BMP5, BMP6
2Pathways in cancer2023.0PIK3CA, PIAS3, PIK3R2, PIK3R1, PIK3CG, RELA
3Osteoclast differentiation2019.6PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA, RELB
4Influenza A2019.3PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA, MYD88
5Renin-Angiotensin Pathway3618.9PIK3R2, PIK3R1, KIT, KITLG, SEMA3A, VCAM1
6Signaling Involved in Cardiac Hypertrophy3618.2PIK3R2, PIK3R1, BRAF, RAF1, RAC1, LIF
7Toll-like receptor signaling pathway2018.1PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA, MYD88
8Focal adhesion2018.1PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF, VTN
9Neurotrophin signaling pathway2017.0PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA, BRAF
10Apoptotic Pathways in Synovial Fibroblasts3616.9PIK3R2, PIK3R1, KIT, KITLG, SEMA3A, BMP2
11Activation of PKC through GPCR3616.7PIK3R2, PIK3R1, KIT, KITLG, SEMA3A, BMP2
12Development_IGF-1 receptor signaling4116.5PIK3CA, PIK3R2, PIK3R1, REL, RELA, RELB
13Immune response_IL-4 signaling pathway4116.0PIK3CA, PIK3R2, PIK3R1, REL, RELA, RELB
14Immune response Fc epsilon RI pathway1016.0PIK3CA, PIK3R2, PIK3R1, REL, RELA, RELB
15Cell Cycle / Checkpoint Control315.8KIF11, PCNA, RB1, VCP, CHEK1, XRCC5
16Development_Prolactin receptor signaling4115.4PIK3CA, PIK3R2, PIK3R1, RELA, VAV1, MYC
17TGF-beta Signaling Pathways3715.4PIK3R2, PIK3R1, PIK3CG, NCOR2, REL, RELA
18Immune response ICOS pathway in T-helper cell1014.8PIK3CA, PIK3R2, PIK3R1, PIK3CG, REL, RELA
19Development_EGFR signaling pathway4114.8PIK3CA, PIK3R2, PIK3R1, REL, RELB, MYC
20TNF Signaling3614.8BID, BIRC2, BIRC3, CHUK, ATF6, ATF4
21IL-3 Pathway3614.7PIK3R2, PIK3R1, BRAF, RAF1, BCL2L1, CHUK
22Intestinal immune network for IgA production2014.7CD28, CD86, CD40LG, CD80, CD40, ITGA4
23Immune response T cell receptor signaling pathway1014.6REL, RELA, RELB, VAV1, RAF1, RAC1
24Cytokine production by Th17 cells in CF (Mouse model)4114.5REL, RELA, RELB, MYD88, CHUK, JAK2
25Cell cycle2014.5PCNA, RB1, MYC, CHEK1, ATM, CDK6
26IL-4 Pathway3614.4PIK3R2, PIK3R1, BRAF, RAF1, BCL2, BAD
27Development FGFR signaling pathway1014.3PIK3CA, PIK3R2, PIK3R1, RAF1, RAC1, PAK1
28Adipocytokine signaling pathway2014.3RELA, LEP, CHUK, MTOR, JAK2, CD36
29VEGF Signaling Pathway3414.2VEGFA, RAF1, KDR, ITGAV, ITGB3, FLT1
30NGF Pathway3614.1PIK3R2, PIK3R1, BRAF, MYC, RAF1, RAC1
31Regulation of actin cytoskeleton2014.1PIK3R2, PIK3R1, BRAF, VAV1, RAF1, PAK1
32Development_EPO-induced MAPK pathway4114.1PIK3CG, KIT, KITLG, VAV1, RAF1, RAC1
33Fas Signaling3614.1RB1, RAF1, BID, BIRC2, BIRC3, PAK1
34Mucin expression in CF via IL-6, IL-17 signaling pathways4114.0REL, RELA, RELB, CHUK, JUN, JUND
35Development VEGF-family signaling1013.8PIK3CA, PIK3R2, PIK3R1, VTN, RAF1, KDR
36Development_Flt3 signaling4113.7PIK3CA, PIK3R2, PIK3R1, VAV1, RAC1, PAK1
37ErbB Family Pathway3613.7PIK3R2, PIK3R1, BRAF, RAF1, PAK1, JUN
38Development Glucocorticoid receptor signaling1013.7REL, RELA, RELB, CEBPB, JUN, FOS
39Development_CNTF receptor signaling4113.6PIK3CA, PIK3R2, PIK3R1, CNTF, CNTFR, RAF1
40Development_FGF-family signaling4113.6PIK3CA, PIK3R2, PIK3R1, RAF1, RAC1, FGF2
41Immune response IL-6 signaling pathway1013.5REL, RELA, RELB, RAF1, CEBPB, JUND
42Epithelial cell signaling in Helicobacter pylori infection2013.3RELA, RAC1, PAK1, CHUK, JUN, MET
43Cytokine Network3613.3IL10, IL12A, IL12B, IL13, IL15, IL16
44Caspase Cascade3613.1BID, BIRC2, BIRC3, BAD, GZMB, GRB2
45Transcription Role of VDR in regulation of genes involved in osteoporosis1013.0VDR, BGLAP, JUN, FOS, IL1A, IL1B
46ErbB2-ErbB3 Heterodimers3613.0PIK3R2, PIK3R1, RAF1, BAD, FOXO3, GSK3A
47Common Cytokine Receptor Gamma-Chain Family Signaling Pathways3713.0PIK3R1, PIK3CG, BRAF, RAF1, BAD, FOXO1
48Cytoskeleton remodeling FAK signaling1012.8PIK3R2, RAF1, PAK1, KDR, ITGA2, FN1
49Transcription_Role of VDR in regulation of genes involved in osteoporosis4112.7VDR, BGLAP, JUN, FOS, IL1A, IL1B
50Development Leptin signaling via JAK/STAT and MAPK cascades1012.2PIAS3, LEP, JAK2, GRB2, MAPK3, MAP2K1

Compounds for genes affiliated with Myeloma

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Sources:
32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB
See all sources

Compounds related to myeloma according to GeneDecks:

(show top 50)    (show all 439)
idCompoundScoreTop Affiliating Genes
1serine32 60.0PIM2, PIK3CA, PIK3R1, PIK3CG, LRP1, LRP2
2dexamethasone32 42 34 9 9 52.7PIK3CA, PIK3R1, LRP1, NCAM1, PDE4A, REL
3vegf32 42.8PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1, PDE4A
4estrogen32 29.4PIK3R1, LRP5, NCOR2, VWF, PCNA, RBP4
5h2o232 26.4PIK3R1, PIK3CG, PDE4A, SGK1, CNTF, CNTN2
6etoposide32 42 9 9 28.9PIK3CA, PIK3R1, PIK3CG, RECK, CNTN2, PCNA
7heparin32 9 18 9 28.7PIK3CA, PIK3CG, LRP1, LRP2, NCAM1, RECK
8ly29400232 24.9PIK3CA, PIK3R1, PIK3CG, SGK1, VTN, VHL
9forskolin32 42 9 9 26.1PIK3R1, PDE4A, CNTF, CNTN2, BRAF, BMP2
10pge232 21.2PDE4A, CNTF, VTN, SETD2, VCAM1, BMP2
11hydrocortisone32 9 9 20.8KITLG, BMP6, LIF, BGLAP, KDR, MUC1
12pdtc32 18.8PIK3CA, PIK3CG, GCLM, SETD2, VCAM1, RAF1
13thalidomide32 42 9 9 21.2PDE4A, VTN, SELL, VEGFA, BIRC2, BIRC3
14prostaglandin32 17.8PDE4A, CNTF, KITLG, LIF, BDKRB2, SCT
15latex32 17.6CNTN2, KITLG, VWF, VTN, RBP4, NAGLU
16flavopiridol32 9 9 19.5PIK3CG, KIT, RB1, VEGFA, BID, BIRC5
17phorbol32 17.4REL, RBP4, SELL, MYC, RAF1, RAC1
18phospholipid32 17.3PIK3R1, LRP2, PDE4A, VWF, RBP4, RALA
19thymidylate32 17.0PCNA, RB1, VEGFA, VDR, BIRC5, BCL2
20phosphatidylserine32 9 9 18.8RECK, VWF, RAC1, BID, PARP1, BCL2
21depsipeptide32 16.7KITLG, RB1, BRAF, MYC, RAF1, LIF
22potassium32 9 18 9 19.2PIK3CA, NCAM1, PDE4A, SGK1, CNTF, KITLG
23p00332 15.4KIT, RB1, LEP, CHI3L1, MVP, MTRR
24sphingosine32 9 18 9 18.2PIK3R1, VCAM1, PAK1, BCL2L1, S1PR2, S1PR3
25suramin32 9 9 17.2LRP1, NCAM1, RECK, PCNA, VEGFA, BMP6
26n-(4-hydroxyphenyl)retinamide32 14.8CNTN2, RB1, RBP4, MYC, BMP6, RARA
27sialic acid32 14.7NCAM1, RECK, RBP4, SELL, NAGLU, BCR
284-hydroxynonenal32 18 15.7GCLM, MYC, PARP1, CHUK, BAX, MPO
29neomycin32 14.6KITLG, BMP2, CDKN2A, IL13, IL1A, IL3
30dbc-amp32 14.5LRP1, LRP2, NCAM1, PDE4A, NAGLU, BMP4
31uric acid32 18 15.3RBP4, NAGLU, LGALS1, LGALS9, UMOD, LEP
32parthenolide32 14.0PIK3CG, BID, BIRC3, BCL2L1, CHUK, JAK2
33erythromycin32 9 9 15.9VCAM1, BCL2L1, MPO, CD40LG, ITGB2, MMP2
34con a32 13.8LGALS1, LBR, CD28, CD79A, CD69, ITGB2
35ibuprofen32 9 18 9 16.7VCAM1, BMP6, BDNF, LEP, CHUK, MMP1
36ethidium bromide32 13.5VWF, VTN, BIRC5, PARP1, MVP, BAX
37fluticasone propionate32 42 9 9 16.5VCAM1, BGLAP, MPO, MMP9, IL13, IL16
38crcs32 13.4PIK3CA, RB1, BRAF, BIRC5, MUC1, MSH6
39acetaminophen32 34 9 18 9 17.4PCNA, NAT2, MYC, BCL2L1, B2M, ANXA5
40deoxyribonucleic acid32 13.4PCNA, NAT2, BMP2, BMP4, LIF, SCT
41mycophenolate mofetil32 9 9 15.2SELP, CD79A, CD36, CD40LG, CD40, MMP1
42pge132 13.0PDE4A, VWF, SELL, B2M, CD40, CD9
43kininogen32 13.0VWF, VTN, SELP, SERPINC1, CLEC3B, BDKRB1
44il-1232 12.9CD86, CD40LG, IL10, IL12B, IL12RB1, IL13
45cerivastatin32 9 9 14.9BMP2, RAC1, MMP1, CCL2, CCL5, ICAM1
46betulinic acid32 12.9BIRC5, PARP1, BCL2, BCL2L1, MCL1, FASLG
47go 697632 42 13.8PIK3CG, CHEK1, CDK1, CDH1, MMP2, IL8
48carbamazepine32 34 9 9 15.3NAGLU, CD36, IGFBP3, ALPP, GLUD1, CYP3A4
49cetuximab32 34 9 9 15.3BRAF, KDR, CDKN1B, CDKN3, AREG, FCGR1A
50apocynin32 11.9SETD2, VCAM1, RAC1, MPO, JUN, JAK2

GO Terms for genes affiliated with Myeloma

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Sources:
12Gene Ontology
See all sources

Cellular components related to myeloma according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563443.0PIAS3, LRP1, NCOR2, PDCD11, PDCD5, PDE4A
2cytoplasmGO:00573742.9PIAS3, PIK3CG, LRP1, PDCD5, RELA, WARS
3cytosolGO:00582937.7PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDCD11, PDE4A
4extracellular spaceGO:00561529.0LRP2, CNTF, KIT, KITLG, VTN, SFRP1
5integral to plasma membraneGO:00588726.3LRP1, NCR1, NCR2, CNTN2, KIR3DS1, KIR2DS4
6nucleoplasmGO:00565422.1NCOR2, REL, RELA, PCNA, RB1, VHL
7external side of plasma membraneGO:00989720.0NCAM1, KIT, VWF, SELL, SELP, VCAM1
8cell surfaceGO:00998617.3LRP6, NCAM1, CNTN2, SFRP1, SFRP4, BST2
9plasma membraneGO:005886INFPIK3R1, PIK3CG, LRP2, LRP5, LRP6, NCAM1
10extracellular regionGO:005576INFNCAM1, KITLG, VWF, VTN, SERPINC1, SEMA3A

Biological processes related to myeloma according to GeneDecks:

(show top 50)    (show all 74)
idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691527.1PDCD5, SGK1, SFRP5, SEMA3A, BOK, BNIP3
2immune responseGO:00695523.6KIR3DS1, VTN, VAV1, BMP6, RAG1, LIF
3positive regulation of transcription from RNA polymerase II promoterGO:04594422.2LRP5, LRP6, RELA, SFRP2, RB1, VEGFA
4positive regulation of cell proliferationGO:00828422.1LRP5, CNTF, CNTFR, KIT, SFRP1, SFRP2
5blood coagulationGO:00759621.6PIK3CA, PIK3R2, PIK3R1, PIK3CG, KIF11, VWF
6inflammatory responseGO:00695420.4PIK3CG, RELA, KIT, SELP, MYD88, BMP2
7negative regulation of apoptotic processGO:04306620.0PIK3CG, RELA, SFRP1, BRAF, VEGFA, MYC
8innate immune responseGO:04508719.8PIK3CG, RELA, BST2, MYD88, BCL10, BCL2
9negative regulation of cell proliferationGO:00828519.6PIM2, WARS, SFRP1, SFRP2, SFRP4, SFRP5
10response to drugGO:04249319.5LRP2, PDE4A, SFRP1, SFRP2, GCLM, MYC
11anti-apoptosisGO:00691619.4PIM2, PIK3CA, RELA, BRAF, VHL, BNIP3
12positive regulation of transcription, DNA-dependentGO:04589319.0PIM2, LRP5, LRP6, REL, RELA, SFRP1
13cell adhesionGO:00715518.9NCAM1, CNTN2, KITLG, VWF, VTN, SELL
14cytokine-mediated signaling pathwayGO:01922118.8NCAM1, RELA, KIT, VCAM1, MYD88, RANBP2
15induction of apoptosisGO:00691717.9PDCD5, BOK, BNIP3, BIK, BCL10, BCL2L11
16cell-cell signalingGO:00726717.6SFRP2, BST2, BMP2, CGB, CD33, CD70
17protein phosphorylationGO:00646817.4PIM2, SGK1, BRAF, BMPR1B, RARA, RAF1
18cell proliferationGO:00828317.0PIM2, LRP2, KITLG, PCNA, BST2, BOK
19platelet activationGO:03016816.7PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF, SELP
20negative regulation of transcription, DNA-dependentGO:04589216.6RELA, SFRP1, SFRP2, RB1, VDR, BMP2
21positive regulation of apoptotic processGO:04306516.4LRP6, SFRP1, SFRP2, SFRP4, BMP2, BMP4
22positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312316.1PIM2, REL, RELA, BST2, VAPA, MYD88
23leukocyte migrationGO:05090015.8PIK3CA, PIK3R2, PIK3R1, SELL, SELP, FYN
24angiogenesisGO:00152515.4PIK3CA, PIK3CG, WARS, SETD2, VEGFA, KDR
25T cell costimulationGO:03129515.3PIK3CA, PIK3R2, PIK3R1, VAV1, RAC1, PAK1
26response to hypoxiaGO:00166615.2VEGFA, VCAM1, BNIP3, BMP2, RAF1, PAK1
27regulation of apoptotic processGO:04298115.1SGK1, BTG1, VCP, RAF1, BIRC5, BCL3
28insulin receptor signaling pathwayGO:00828615.1PIK3CA, PIK3R2, PIK3R1, RAF1, MTOR, CDK1
29induction of apoptosis by intracellular signalsGO:00862914.7BNIP3, MYC, BMF, BID, BCL2, BCL2L1
30G1/S transition of mitotic cell cycleGO:00008214.7PIM2, PCNA, RB1, BCL2, CKS1B, UBC
31cellular response to mechanical stimulusGO:07126014.6BNIP3, MYD88, BCL10, CHEK1, BAD, BAK1
32induction of apoptosis by extracellular signalsGO:00862414.6VDR, VAV1, RAC1, BCL2L11, UBC, BAD
33fibroblast growth factor receptor signaling pathwayGO:00854314.5PIK3CA, PIK3R1, BRAF, RAF1, CHUK, UBC
34activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691914.5VCP, BOK, MYC, BCL2L11, BBC3, BAD
35response to lipopolysaccharideGO:03249614.4SELP, BDKRB1, P2RX7, CEBPB, JUN, JAK2
36positive regulation of cell migrationGO:03033514.4VEGFA, BMP2, KDR, JAK2, ITGAV, ITGB1
37positive regulation of NF-kappaB transcription factor activityGO:05109214.3RELA, MYD88, BCL10, CHUK, UBC, CD40
38protein autophosphorylationGO:04677714.3KIT, PAK1, KDR, ZAP70, MTOR, AURKA
39toll-like receptor signaling pathwayGO:00222414.2RELA, MYD88, BCL10, CHUK, UBC, JUN
40Toll signaling pathwayGO:00806314.0RELA, MYD88, CHUK, UBC, JUN, CD14
41interferon-gamma-mediated signaling pathwayGO:06033314.0NCAM1, VCAM1, CIITA, MT2A, B2M, JAK1
42positive regulation of peptidyl-serine phosphorylationGO:03313813.6PIK3CA, SFRP2, BRAF, VEGFA, RAF1, LIF
43MyD88-dependent toll-like receptor signaling pathwayGO:00275513.6RELA, MYD88, CHUK, UBC, JUN, CDK1
44T cell receptor signaling pathwayGO:05085213.5PIK3CA, PIK3R2, PIK3R1, RELA, PAK1, BCL10
45toll-like receptor 1 signaling pathwayGO:03413013.5RELA, MYD88, CHUK, UBC, JUN, CDK1
46toll-like receptor 2 signaling pathwayGO:03413413.5RELA, MYD88, CHUK, UBC, JUN, CDK1
47organ regenerationGO:03110013.1LRP2, LIF, LIFR, LCP1, BAK1, CEBPA
48agingGO:00756813.0LRP2, VDR, VCAM1, BAK1, JUN, GRB2
49regulation of immune responseGO:050776INFSELL, VCAM1, BCL6, B2M, CD3D, CD81
50virus-host interactionGO:019048INFPIK3R1, RELA, RB1, NACA, VCAM1, BNIP3

Molecular functions related to myeloma according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552423.2PIM2, PIK3CA, PIK3CG, SGK1, WARS, KIT
2cytokine activityGO:00512519.6CNTF, KITLG, VEGFA, BMP2, BMP4, BMP5
3receptor activityGO:00487217.3LRP1, SEMA3A, CD33, CD86, CD4, CD1D
4growth factor activityGO:00808317.2CNTF, KITLG, VEGFA, BMP2, BMP4, BMP5
5protein homodimerization activityGO:04280317.2LRP6, KIT, VWF, BST2, VEGFA, BNIP3
6protein kinase bindingGO:01990116.6RELA, KIF11, PAK1, BCL10, BCL2L1, BAD
7protein heterodimerization activityGO:04698216.4GCLM, BRAF, VEGFA, BOK, BNIP3, VAPA
8identical protein bindingGO:04280216.0RELA, CNTN2, SFRP1, PCNA, VCP, BNIP3
9receptor bindingGO:00510215.7LRP6, CNTFR, VCP, BMP2, RARA, LIF
10enzyme bindingGO:01989915.5PIAS3, BTG1, VHL, RARA, RAC1, BLZF1
11transcription factor bindingGO:00813415.3PDCD11, RELA, RB1, VHL, MYC, RARA
12transmembrane signaling receptor activityGO:00488813.8NCR2, LAG3, CD79A, CD27, CD3D, CD69
13tumor necrosis factor receptor bindingGO:00516413.3CD70, CD40LG, FASLG, FADD, CASP8, TRAF2
14protein bindingGO:005515INFPIK3CA, PIAS3, PIK3R2, PIK3R1, PIK3CG, LRP1

Sources for Myeloma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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