MCID: MYL020
MIFTS: 50

Myelomeningocele malady

Categories: Rare diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Myelomeningocele

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 25GTR, 48Novoseek, 2CDC, 37MeSH, 28ICD10, 43NCIt, 66UMLS, 29ICD10 via Orphanet, 60SNOMED-CT
See all MalaCards sources

Summaries for Myelomeningocele

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NIH Rare Diseases:46 Myelomeningocele is the most severe form of spina bifida. it happens when parts of the spinal cord and nerves come through the open part of the spine. it causes nerve damage and other disabilities. seventy to ninety percent of children with this condition also have too much fluid on their brains (hydrocephalus). this happens because fluid that protects the brain and spinal cord is unable to drain like it should. the fluid builds up, causing pressure and swelling. without treatment, a person’s head grows too big, and they may have brain damage. other disorders of the spinal cord may be seen, including syringomyelia and hip dislocation. the cause of myelomeningocele is unknown. however, low levels of folic acid in a woman's body before and during early pregnancy is thought to play a part in this type of birth defect. last updated: 1/11/2013

MalaCards based summary: Myelomeningocele, also known as meningomyelocele, is related to spina bifida aperta and neural tube defects, folate-sensitive. An important gene associated with Myelomeningocele is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways are Folate-Alcohol and Cancer Pathway and Wnt / Hedgehog / Notch. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Disease Ontology:11 A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes.

CDC:2 Spina bifida is a major birth defect of a person’s spine. With good quality medical care people with spina bifida can reach their full potential. If you have spina bifida, or know someone who does, it’s important to get the facts so that you can make the best possible health care choices.

Related Diseases for Myelomeningocele

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Diseases related to Myelomeningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1spina bifida aperta28.6MTHFD1, MTHFR, T, VANGL1, VANGL2
2neural tube defects, folate-sensitive28.6MTHFD1, MTHFR, MTR, MTRR
3neural tube defects24.8CBS, CELSR1, DACT1, MTHFD1, MTHFR, MTR
4renal agenesis meningomyelocele mullerian defect11.9
5schwartz cohen-addad lambert syndrome11.0
6chiari malformation10.6
7chiari malformation type ii10.6
8hydrocephalus10.3
9functional diarrhea10.2CBS, MTHFR
10critical limb ischemia10.2CELSR1, DACT1, SCRIB
11neurogenic bladder10.2
12candidiasis, familial, 6, autosomal dominant10.2CBS, MTHFR
13cervicitis10.2
14scoliosis10.1
15noma10.1MTHFD1, MTHFR
16homocystinuria due to mthfr deficiency10.0MTHFR, MTR
17neurogenic bowel10.0
18cerebritis10.0
19diastematomyelia9.9
20clubfoot9.9
21vaginal adenoma9.9PRICKLE1, VANGL1, VANGL2
22heterotaxy, visceral, 1, x-linked9.9
23congenital laryngeal palsy9.9
24spinal cord injury9.9
25meningocele9.9
26constipation9.9
27syringomyelia9.9
28strabismus9.9
29encephalocele9.9
30tethered cord syndrome9.9
31syringohydromyelia9.9
32serine deficiency9.8MTHFR, MTR
33methylmalonic aciduria and homocystinuria type cblg9.8MTHFR, MTR
34apraxia9.8CBS, MTHFR
35obesity9.8
36focal dermal hypoplasia9.8
37anencephaly9.8
38cerebral palsy9.8
39tethered spinal cord syndrome9.8
40choroiditis9.8
41urethritis9.8
42epilepsy9.8
43teratoma9.8
44sleep disorder9.8
45talipes equinovarus9.8
46lipomyelomeningocele9.8
47growth hormone deficiency9.8
48spasticity9.8
49congenital intrinsic factor deficiency9.7MTR, MTRR
50x-linked disease9.7MTR, MTRR

Graphical network of the top 20 diseases related to Myelomeningocele:



Diseases related to myelomeningocele

Symptoms for Myelomeningocele

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Drugs & Therapeutics for Myelomeningocele

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Drugs for Myelomeningocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
OxybutyninPhase 4655633-20-54634
Synonyms:
1508-65-2 (hydrochloride)
4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester
4-(diethylamino)-2-butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate
4-(diethylamino)-2-butynyl-alpha-phenylcyclohexaneglycolate
4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
4-Diethylamino-2-butinyl alpha-cyclohexylmandelat
4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate
5633-20-5
AC-2153
AC1L1ILV
BPBio1_000214
BRD-A65013509-003-03-8
BSPBio_000194
Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester
C07360
CCRIS 1923
CHEBI:7856
CHEMBL1231
CID4634
Cyclohexaneglycolic acid, .alpha.-phenyl-, 4-(diethylamino)-2-butynyl ester
Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester
Cystrin
D00465
DB01062
Ditropan
Ditropan, Lyrinel XL, Oxytrol, Oxybutynin
FT-0082890
HSDB 3270
I06-2117
L000923
LS-28714
 
Lopac0_000923
MolPort-003-849-741
NCGC00015767-06
NCGC00089795-02
Oxibutinina
Oxibutinina [INN-Spanish]
Oxibutyninum
Oxybutinin
Oxybutynin
Oxybutynin (USAN/INN)
Oxybutynin Base
Oxybutynin Chloride
Oxybutynin Hydrochloride
Oxybutynin [USAN:INN:BAN]
Oxybutynin topical gel
Oxybutynine
Oxybutynine [INN-French]
Oxybutyninum
Oxybutyninum [INN-Latin]
Oxytrol
Oxytrol (TN)
Pollakisu
Prestwick0_000287
Prestwick1_000287
Prestwick2_000287
Prestwick3_000287
S1754_Selleck
SPBio_002413
Transdermal patch
UNII-K9P6MC7092
oxybutynin
oxybutynin topical gel
transdermal patch
2
AcetylcholinePhase 475251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
3
DarifenacinPhase 222133099-04-4444031
Synonyms:
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
133099-04-4
2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
AC-302
AC1L9FKY
CHEBI:391960
CHEMBL1346
CID444031
D03654
 
DB00496
Darifenacin
Darifenacin (USAN/INN)
Darifenacina
Darifenacinum
Darifénacine
Emselex
Enablex
LS-187359
MolPort-005-943-011
NCGC00168775-01
STOCK6S-73577
darifenacin
4ACIDOPHILUSNutraceuticalPhase 1502
5
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
6COLANutraceutical1824

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord LesionsCompletedNCT01208584Phase 4
2Effect of Botulinum Toxin in Neurogenic Bladders in Children With MyelomeningoceleActive, not recruitingNCT00175123Phase 4
32 Week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Yrs) With Neurogenic Detrusor OveractivitySuspendedNCT00712322Phase 2
4Fetoscopic Meningomyelocele Repair StudyRecruitingNCT02230072Phase 1
5Bacteriuria Eradication Through ProbioticsEnrolling by invitationNCT00717600Phase 1
6Management of Myelomeningocele Study (MOMS)CompletedNCT00060606
7Feasibility of the Portable YouGrabber SystemCompletedNCT02368223
8Prenatal Surgical Repair of Fetal MyelomeningoceleRecruitingNCT01983345
9Extended Criteria For Fetal Myelomeningocele RepairRecruitingNCT02664207
10Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0RecruitingNCT02509377
11Evaluation of Hysterotomy Site After Open Fetal SurgeryRecruitingNCT02493062
12Reciprocating Gait Orthoses for Paraplegia PatientsRecruitingNCT02227407
13Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
14Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled TrialRecruitingNCT02361450
15Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord InjuryRecruitingNCT01606618
16Reliability of the Melbourne AssessmentActive, not recruitingNCT02595411
17Psychosocial Adjustment of Adolescents With Spina BifidaActive, not recruitingNCT00891891
18Prenatal Endoscopic Repair of Fetal Spina BifidaNot yet recruitingNCT02390895

Search NIH Clinical Center for Myelomeningocele


Cochrane evidence based reviews: meningomyelocele

Genetic Tests for Myelomeningocele

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Genetic tests related to Myelomeningocele:

id Genetic test Affiliating Genes
1 Myelomeningocele25

Anatomical Context for Myelomeningocele

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MalaCards organs/tissues related to Myelomeningocele:

34
Spinal cord, Brain, Bone, Skin, Colon, Heart, Smooth muscle

Animal Models for Myelomeningocele or affiliated genes

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Publications for Myelomeningocele

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Articles related to Myelomeningocele:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Surgical Management of Hip Problems in Myelomeningocele: A Review Article. (27517062)
2016
2
Latex sensitization in patients with myelomeningocele undergoing urological procedures: prevalence and associated factors. (27033690)
2016
3
Trends in epidemiology and hospitalization utilization for myelomeningocele repair from 2000 to 2009. (27112355)
2016
4
Fetal Heart Rate during in Utero Myelomeningocele Repair: Effect of Anesthesia and Analgesia. (27509040)
2016
5
Clinical and ultrasonographic criteria for using ventriculoperitoneal shunts in newborns with myelomeningocele. (26352494)
2015
6
Surgical results of strabismus correction in patients with myelomeningocele. (25714531)
2015
7
OP-21 QUALITY OF LIFE BEFORE AND AFTER BIOFEEDBACK TREATMENT IN MYELOMENINGOCELE PATIENT. (26439562)
2015
8
Bladder Function After Fetal Surgery for Myelomeningocele. (26416930)
2015
9
Muscle ultrasound quantifies segmental neuromuscular outcome in pediatric myelomeningocele. (24210858)
2014
10
Bladder Changes After Several Coverage Modalities in the Surgically Induced Model of Myelomeningocele in Lambs. (24126194)
2014
11
Predictors of the need for cerebrospinal fluid diversion in patients with myelomeningocele. (24877604)
2014
12
Family-based association study between SLC2A1, HK1, and LEPR polymorphisms with myelomeningocele in Chile. (23427181)
2013
13
Treatment of spinal deformity associated with myelomeningocele in young children with the use of the four-rib construct. (23787773)
2013
14
Fetal surgery for myelomeningocele: a critical appraisal. (23572465)
2013
15
Fetal myelomeningocele repair: a new standard of care. (22840506)
2012
16
Open fetal surgery for myelomeningocele. (22380954)
2012
17
Prenatal versus postnatal repair of myelomeningocele. (21714661)
2011
18
Latencies obtained of the somatosensory evoked potentials of the median and tibial nerve in rhesus monkey undergoing intrauterine laminectomy to simulate myelomeningocele. (22380994)
2011
19
Decreased incidence of myelomeningocele at birth: effect of folic acid recommendations or prenatal diagnostics? (21552997)
2011
20
Repeated Botulinum-A toxin injection in the treatment of neuropathic bladder dysfunction and poor bladder compliance in children with myelomeningocele. (21674597)
2011
21
Double myelomeningocele: case report. (21513453)
2011
22
Fetal surgery for myelomeningocele? (21306233)
2011
23
Transanal irrigation in myelomeningocele children: an alternative, safe and valid approach for neurogenic constipation. (20084075)
2010
24
Local and regional flap closure in myelomeningocele repair: a 15-year review. (20195618)
2010
25
Bone mineral density in children with myelomeningocele. (18811711)
2009
26
Bulbar urethral ligation for managing persistent urinary incontinence in young men with myelomeningocele. (19245443)
2009
27
Oral findings and dental care in a patient with myelomeningocele: case report of a 3-year-old child. (20126914)
2009
28
Independence in the toilet activity in children and adolescents with myelomeningocele--managing clean intermittent catheterization in a hospital setting. (19604172)
2009
29
Primary closure of large thoracolumbar myelomeningocele with bilateral latissimus dorsi flaps. (19338414)
2009
30
Vascular and apoptotic changes in the placode of myelomeningocele mice during the final stages of in utero development. (18671624)
2008
31
Complications of clean intermittent catheterization in young females with myelomeningocele: 10 to 19 years of followup. (17632181)
2007
32
New anchoring method for tarsal tendon transfers in myelomeningocele patients. (19308534)
2007
33
Intrauterine surgery in myelomeningocele. (17716961)
2007
34
Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta? (17556822)
2007
35
Double myelomeningocele in a neonate: Case report and review of the literature. (15936872)
2006
36
Evaluation of sexual function in young men with spina bifida and myelomeningocele using the International Index of Erectile Function. (16504267)
2006
37
Influence of family environment on language outcomes in children with myelomeningocele. (16101655)
2005
38
Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele. (16190875)
2005
39
Kyphectomy in myelomeningocele with a modified Dunn-McCarthy technique followed by an anterior inlayed strut graft. (14714245)
2004
40
Prenatal intervention for urinary obstruction and myelomeningocele. (15707516)
2004
41
Botulinum-A toxin injection into the detrusor: a safe alternative in the treatment of children with myelomeningocele with detrusor hyperreflexia. (14713840)
2004
42
Grip force parameters in precision grip of individuals with myelomeningocele. (12647926)
2003
43
Maternal-fetal surgery for treatment of myelomeningocele. (12696793)
2003
44
Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. (12632366)
2003
45
Fetal surgery for myelomeningocele: panacea or peril? (12557043)
2003
46
Preservation of renal function in children with myelomeningocele managed with basic newborn evaluation and close followup. (12478177)
2003
47
Treatment of neuropathic bladder using botulinum toxin A in a 1-year-old child with myelomeningocele. (11793122)
2001
48
Ambulation in Patients with Myelomeningocele: A 12-Year Follow-up. (17053651)
2001
49
Peripheral chemoreceptor function in children with myelomeningocele and Arnold-Chiari malformation type 2. (7634879)
1995
50
Bladder-outlet reconstruction in neurogenic bladder due to myelomeningocele. (3337968)
1988

Variations for Myelomeningocele

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Expression for genes affiliated with Myelomeningocele

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Search GEO for disease gene expression data for Myelomeningocele.

Pathways for genes affiliated with Myelomeningocele

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Pathways related to Myelomeningocele according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.6CBS, MTHFR
29.5PAX3, SCRIB, VANGL1
3
Show member pathways
9.4MTHFR, MTRR
49.1MTR, MTRR
5
Show member pathways
9.1MTR, MTRR
6
Show member pathways
9.1CBS, MTHFR, MTR
7
Show member pathways
9.1CBS, MTHFR, MTR
8
Show member pathways
9.0DACT1, PRICKLE1, SCRIB, VANGL2
9
Show member pathways
8.5CBS, MTR, MTRR
10
Show member pathways
8.4MTHFD1, MTHFR, MTR, MTRR
11
Show member pathways
7.7CBS, MTHFD1, MTHFR, MTR, MTRR

GO Terms for genes affiliated with Myelomeningocele

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Cellular components related to Myelomeningocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058296.7CBS, DACT1, MTHFD1, MTHFR, MTR, MTRR

Biological processes related to Myelomeningocele according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:006048910.3CELSR1, VANGL2
2lateral sprouting involved in lung morphogenesisGO:006049010.3CELSR1, VANGL2
3orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:006048810.3CELSR1, VANGL2
4planar cell polarity pathway involved in neural tube closureGO:009017910.3CELSR1, VANGL2
5establishment of body hair planar orientationGO:004810510.3CELSR1, VANGL2
6tetrahydrofolate interconversionGO:003599910.3MTHFD1, MTHFR
7post-anal tail morphogenesisGO:003634210.2T, VANGL2
8establishment of planar polarityGO:000173610.2CELSR1, VANGL2
9apical protein localizationGO:004517610.1CELSR1, VANGL2
10transsulfurationGO:00193469.9CBS, MTHFD1
11anterior/posterior pattern specificationGO:00099529.8CELSR1, T, VANGL2
12sulfur amino acid metabolic processGO:00000969.7MTR, MTRR
13cobalamin metabolic processGO:00092359.7MTR, MTRR
14hair follicle developmentGO:00019429.6CELSR1, VANGL2
15homocysteine catabolic processGO:00434189.6CBS, MTRR
16homocysteine metabolic processGO:00506679.6CBS, MTHFR
17methionine metabolic processGO:00065559.6MTHFD1, MTHFR, MTRR
18Wnt signaling pathway, planar cell polarity pathwayGO:00600719.5CELSR1, PRICKLE1, VANGL1, VANGL2
19wound healingGO:00420609.4CELSR1, SCRIB, VANGL2
20methionine biosynthetic processGO:00090869.3MTHFD1, MTR, MTRR
21folic acid metabolic processGO:00466559.1MTHFD1, MTHFR, MTRR
22neural tube closureGO:00018438.6CELSR1, MTHFD1, PRICKLE1, SCRIB, T, VANGL2
23oxidation-reduction processGO:00551148.0CBS, MTHFD1, MTHFR, MTRR

Molecular functions related to Myelomeningocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:007234110.0CBS, MTHFR
2NADP bindingGO:00506619.8MTHFR, MTRR
3protein bindingGO:00055155.2CBS, CELSR1, DACT1, MTHFD1, MTR, MTRR

Sources for Myelomeningocele

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
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30ICD9CM
31IUPHAR
32KEGG
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39MGI
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65Tumor Gene Family of Databases
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