MCID: MYL020
MIFTS: 50

Myelomeningocele malady

Categories: Rare diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Myelomeningocele

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 27GTR, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
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Summaries for Myelomeningocele

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NIH Rare Diseases:48 Myelomeningocele is the most severe form of spina bifida. It happens when parts of the spinal cord and nerves come through the open part of the spine. It causes nerve damage and other disabilities. Seventy to ninety percent of children with this condition also have too much fluid on their brains (hydrocephalus). This happens because fluid that protects the brain and spinal cord is unable to drain like it should. The fluid builds up, causing pressure and swelling. Without treatment, a person’s head grows too big, and they may have brain damage. Other disorders of the spinal cord may be seen, including syringomyelia and hip dislocation. The cause of myelomeningocele is unknown. However, low levels of folic acid in a woman's body before and during early pregnancy is thought to play a part in this type of birth defect. Last updated: 1/11/2013

MalaCards based summary: Myelomeningocele, also known as meningomyelocele, is related to neural tube defects, folate-sensitive and spina bifida aperta. An important gene associated with Myelomeningocele is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways are Folate-Alcohol and Cancer Pathway and Wnt / Hedgehog / Notch. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Disease Ontology:11 A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes.

CDC:2 Spina bifida is a major birth defect of a person’s spine. With good quality medical care people with spina bifida can reach their full potential. If you have spina bifida, or know someone who does, it’s important to get the facts so that you can make the best possible health care choices.

Related Diseases for Myelomeningocele

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Diseases related to Myelomeningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1neural tube defects, folate-sensitive30.5MTHFD1, MTHFR, MTR, MTRR
2spina bifida aperta28.7MTHFD1, MTHFR, T, VANGL1, VANGL2
3neural tube defects26.5CBS, CELSR1, DACT1, MTHFD1, MTHFR, MTR
4renal agenesis meningomyelocele mullerian defect11.8
5chiari malformation type ii11.3
6chiari malformation11.2
7schwartz cohen-addad lambert syndrome10.8
8heterotaxy, visceral, 1, x-linked10.8
9critical limb ischemia10.2CELSR1, DACT1, SCRIB
10hydrocephalus10.2
11functional diarrhea10.2CBS, MTHFR
12candidiasis, familial, 6, autosomal dominant10.1CBS, MTHFR
13homocystinuria due to mthfr deficiency10.1MTHFR, MTR
14noma10.1MTHFD1, MTHFR
15neurogenic bladder10.1
16cervicitis10.1
17serine deficiency10.0MTHFR, MTR
18vaginal adenoma10.0PRICKLE1, VANGL1, VANGL2
19scoliosis10.0
20methylmalonic aciduria and homocystinuria type cblg10.0MTHFR, MTR
21congenital intrinsic factor deficiency10.0MTR, MTRR
22x-linked disease9.9MTR, MTRR
23dysferlinopathy9.9MTR, MTRR
24neurogenic bowel9.8
25cerebritis9.8
26diastematomyelia9.8
27clubfoot9.8
28apraxia9.8CBS, MTHFR
29homocystinuria due to defect in methylation cbl g9.8MTHFR, MTR, MTRR
30x-linked congenital generalized hypertrichosis9.8MTHFR, MTR, MTRR
31agammaglobulinemia 29.7MTHFR, MTR, MTRR
32spinal cord injury9.7
33meningocele9.7
34constipation9.7
35syringomyelia9.7
36strabismus9.7
37encephalocele9.7
38tethered cord syndrome9.7
39syringohydromyelia9.7
40exostosis9.7MTHFD1, MTR
41obesity9.6
42focal dermal hypoplasia9.6
43anencephaly9.6
44cerebral palsy9.6
45tethered spinal cord syndrome9.6
46choroiditis9.6
47urethritis9.6
48epilepsy9.6
49teratoma9.6
50congenital diaphragmatic hernia9.6

Graphical network of the top 20 diseases related to Myelomeningocele:



Diseases related to myelomeningocele

Symptoms & Phenotypes for Myelomeningocele

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MGI Mouse Phenotypes related to Myelomeningocele according to GeneCards Suite gene sharing:

41 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.5CELSR1, PAX3, PRICKLE1, T, VANGL2
2MP:00053779.1CELSR1, PAX3, PRICKLE1, SCRIB, VANGL1, VANGL2
3MP:00053819.1DACT1, PAX3, PRICKLE1, SCRIB, T, VANGL2
4MP:00053679.0DACT1, PAX3, PRICKLE1, SCRIB, T, VANGL2
5MP:00053889.0CELSR1, PAX3, PRICKLE1, SCRIB, VANGL1, VANGL2
6MP:00030128.8DACT1, MTHFR, PAX3, PRICKLE1, SCRIB, T
7MP:00053898.6CELSR1, DACT1, MTHFR, SCRIB, T, VANGL1
8MP:00053918.5CELSR1, MTHFR, PAX3, PRICKLE1, SCRIB, VANGL2
9MP:00053858.3DACT1, MTHFD1, PAX3, PRICKLE1, T, VANGL1
10MP:00053908.3CELSR1, DACT1, MTHFR, PAX3, PRICKLE1, T
11MP:00053807.7CELSR1, DACT1, MTHFD1, PAX3, PRICKLE1, SCRIB
12MP:00053717.5CELSR1, DACT1, MTHFD1, MTHFR, PAX3, PRICKLE1
13MP:00036317.4CELSR1, DACT1, MTHFD1, MTHFR, PAX3, PRICKLE1
14MP:00107686.9CELSR1, DACT1, MTHFD1, MTHFR, MTR, PAX3
15MP:00053786.6CELSR1, DACT1, MTHFD1, MTHFR, MTRR, PAX3

Drugs & Therapeutics for Myelomeningocele

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Drugs for Myelomeningocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 477651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2
Oxybutyninapproved, investigationalPhase 4675633-20-54634
Synonyms:
1508-65-2 (hydrochloride)
4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester
4-(diethylamino)-2-butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate
4-(diethylamino)-2-butynyl-alpha-phenylcyclohexaneglycolate
4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
4-Diethylamino-2-butinyl alpha-cyclohexylmandelat
4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate
5633-20-5
AC-2153
AC1L1ILV
BPBio1_000214
BRD-A65013509-003-03-8
BSPBio_000194
Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester
C07360
CCRIS 1923
CHEBI:7856
CHEMBL1231
CID4634
Cyclohexaneglycolic acid, .alpha.-phenyl-, 4-(diethylamino)-2-butynyl ester
Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester
Cystrin
D00465
DB01062
Ditropan
Ditropan, Lyrinel XL, Oxytrol, Oxybutynin
FT-0082890
HSDB 3270
I06-2117
L000923
LS-28714
 
Lopac0_000923
MolPort-003-849-741
NCGC00015767-06
NCGC00089795-02
Oxibutinina
Oxibutinina [INN-Spanish]
Oxibutyninum
Oxybutinin
Oxybutynin
Oxybutynin (USAN/INN)
Oxybutynin Base
Oxybutynin Chloride
Oxybutynin Hydrochloride
Oxybutynin [USAN:INN:BAN]
Oxybutynin topical gel
Oxybutynine
Oxybutynine [INN-French]
Oxybutyninum
Oxybutyninum [INN-Latin]
Oxytrol
Oxytrol (TN)
Pollakisu
Prestwick0_000287
Prestwick1_000287
Prestwick2_000287
Prestwick3_000287
S1754_Selleck
SPBio_002413
Transdermal patch
UNII-K9P6MC7092
oxybutynin
oxybutynin topical gel
transdermal patch
3onabotulinumtoxinAPhase 4626
4abobotulinumtoxinAPhase 4626
5Botulinum ToxinsPhase 4669
6Neurotransmitter AgentsPhase 4, Phase 217734
7Peripheral Nervous System AgentsPhase 422776
8Botulinum Toxins, Type APhase 4630
9Cholinergic AgentsPhase 4, Phase 23846
10incobotulinumtoxinAPhase 4635
11Neuromuscular AgentsPhase 41129
12
Darifenacinapproved, investigationalPhase 222133099-04-4444031
Synonyms:
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
133099-04-4
2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
AC-302
AC1L9FKY
CHEBI:391960
CHEMBL1346
CID444031
D03654
 
DB00496
Darifenacin
Darifenacin (USAN/INN)
Darifenacina
Darifenacinum
Darifénacine
Emselex
Enablex
LS-187359
MolPort-005-943-011
NCGC00168775-01
STOCK6S-73577
darifenacin
13Cholinergic AntagonistsPhase 21658
14Muscarinic AntagonistsPhase 21134
15Methenamine hippuratePhase 19
16MethenaminePhase 19
17AcidophilusNutraceuticalPhase 1518
18
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
19ColaNutraceutical1881

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Effect of Botulinum Toxin in Neurogenic Bladders in Children With MyelomeningoceleUnknown statusNCT00175123Phase 4
2Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord LesionsCompletedNCT01208584Phase 4
32 Week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Yrs) With Neurogenic Detrusor OveractivitySuspendedNCT00712322Phase 2
4Bacteriuria Eradication Through ProbioticsUnknown statusNCT00717600Phase 1
5Fetoscopic Meningomyelocele Repair StudyRecruitingNCT02230072Phase 1
6Reciprocating Gait Orthoses for Paraplegia PatientsUnknown statusNCT02227407
7Management of Myelomeningocele Study (MOMS)CompletedNCT00060606
8Feasibility of the Portable YouGrabber SystemCompletedNCT02368223
9Prenatal Surgical Repair of Fetal MyelomeningoceleRecruitingNCT01983345
10Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0RecruitingNCT02509377
11Extended Criteria For Fetal Myelomeningocele RepairRecruitingNCT02664207
12Evaluation of Hysterotomy Site After Open Fetal SurgeryRecruitingNCT02493062
13Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
14Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled TrialRecruitingNCT02361450
15Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord InjuryRecruitingNCT01606618
16Psychosocial Adjustment of Adolescents With Spina BifidaActive, not recruitingNCT00891891
17Reliability of the Melbourne AssessmentActive, not recruitingNCT02595411
18Prenatal Endoscopic Repair of Fetal Spina BifidaNot yet recruitingNCT02390895

Search NIH Clinical Center for Myelomeningocele


Cochrane evidence based reviews: meningomyelocele

Genetic Tests for Myelomeningocele

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Genetic tests related to Myelomeningocele:

id Genetic test Affiliating Genes
1 Myelomeningocele27

Anatomical Context for Myelomeningocele

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MalaCards organs/tissues related to Myelomeningocele:

36
Spinal cord, Brain, Bone, Skin, Colon, Heart, Smooth muscle

Publications for Myelomeningocele

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Articles related to Myelomeningocele:

(show top 50)    (show all 647)
idTitleAuthorsYear
1
Ultrasound functional evaluation of fetuses with myelomeningocele: study of the interpretation of results. (27997256)
2017
2
Ten-year survival of Ugandan infants after myelomeningocele closure. (27767901)
2017
3
Fetal surgery for myelomeningocele: current clinical practice and translational research. (27830929)
2017
4
Reliability of extended dorsal intercostal artery perforator propeller flaps for reconstruction of large myelomeningocele defects. (27894916)
2017
5
Surgical Management of Hip Problems in Myelomeningocele: A Review Article. (27517062)
2016
6
Latex sensitization in patients with myelomeningocele undergoing urological procedures: prevalence and associated factors. (27033690)
2016
7
Correlation of mortality with lesion level in patients with myelomeningocele: a population-based study. (27911247)
2016
8
Trends in epidemiology and hospitalization utilization for myelomeningocele repair from 2000 to 2009. (27112355)
2016
9
Fetal Heart Rate during in Utero Myelomeningocele Repair: Effect of Anesthesia and Analgesia. (27509040)
2016
10
A decision-making guide for the closure of myelomeningocele skin defects with or without primary repair. (27104629)
2016
11
Prenatal surgery for myelomeningocele. (26866841)
2016
12
High-Dose Desflurane for Tocolysis During Intrapartum Myelomeningocele Repair in a Patient with Post-Adriamycin Cardiomyopathy. (27182782)
2016
13
Closure of Myelomeningocele Defects Using a Limberg Flap or Direct Repair. (26848442)
2016
14
Urological Outcome of the Xiao Procedure in Children with Myelomeningocele and Lipomyelomeningocele Undergoing Spinal Cord Detethering: Results of a Randomized, Prospective, Double-Blind Study. (27288694)
2016
15
Use of dermal regeneration template to close a giant myelomeningocele in a newborn. (27503247)
2016
16
Independence in self-care activities in children with myelomeningocele: exploring factors based on the International Classification of Function model. (27830629)
2016
17
Footloose: Spinal Myoclonus after Myelomeningocele Repair. (26968832)
2016
18
Adults with myelomeningocele and other forms of spinal dysraphism: hospital care in the United States since the turn of the millennium. (26926705)
2016
19
Neurosurgery concepts: Key perspectives on intrathecal fluorescein for detecting intraoperative cerebrospinal fluid leak during endoscopic endonasal surgery, spinal intraarterial chemotherapy, oligoastrocytoma classification by in situ molecular genetics, and prenatal myelomeningocele closure and the need for cerebrospinal fluid shunt placement. (27857862)
2016
20
Managing fecal incontinence in patients with myelomeningocele in Sub-Saharan Africa: Role of antegrade continence enema (ACE). (27634558)
2016
21
Genetic association of the glycine cleavage system genes and myelomeningocele. (27620832)
2016
22
Kyphectomy in Children With Severe Myelomeningocele-Related Kyphosis. (27927508)
2016
23
The impact of mode of delivery on infant neurologic outcomes in myelomeningocele. (27242203)
2016
24
Quantitative Analysis of Lower Leg Adipose Tissue Distribution in Youth with Myelomeningocele. (26961265)
2016
25
Commentary on "Bone Mineral Content in Infants With Myelomeningocele, With and Without Treadmill Stepping Practice". (27088681)
2016
26
Congenital high airway obstruction syndrome (CHAOS) associated with cervical myelomeningocele. (27874207)
2016
27
Prevalence of latex allergy in a population of patients diagnosed with myelomeningocele. (26914072)
2016
28
Rate of shunt revision as a function of age in patients with shunted hydrocephalus due to myelomeningocele. (27798984)
2016
29
The surgical treatment of spinal deformity in children with myelomeningocele: the role of personalized three-dimensional printed models. (27902634)
2016
30
Health-related quality of life in children with myelomeningocele: a systematic review of the literature. (27381478)
2016
31
Cervical myelomeningocele associated with multiple spinal anomalies. (26994553)
2016
32
Myelomeningocele - a single institute analysis of the years 2007 to 2015. (27086130)
2016
33
Five-Level Posterior Total En Bloc Spondylectomy of Severe Myelomeningocele Kyphosis. (26975984)
2016
34
Impact on family and parental stress of prenatal vs postnatal repair of myelomeningocele. (27263997)
2016
35
Re: Prenatal ultrasound evaluation of segmental level of neurological lesion in fetuses with myelomeningocele: development of a new technique. E.Carreras, A. Maroto, T. Illescas, M. MelAcndez, S. ArAcvalo, J. L. PeirA^, C. G. GarcA-a-Fontecha, M. Belfort and A. Cuxart. Ultrasound Obstet Gynecol 2016; 47: 162-167. (26833638)
2016
36
Management of Lumbosacral Myelomeningocele. (28090243)
2016
37
Right-Sided Congenital Diaphragmatic Hernia and Myelomeningocele: A Rare Association. (28043315)
2016
38
Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele? (27598183)
2016
39
Lack of efficacy of an intradural somatic-to-autonomic nerve anastomosis (Xiao procedure) for bladder control in children with myelomeningocele and lipomyelomeningocele: results of a prospective, randomized, double-blind study. (27137626)
2016
40
An Ideal Flap Alternative for Closure of Myelomeningocele Defects: Dorsal Intercostal Artery Perforator Flap. (28005733)
2016
41
Thirty-day outcomes after postnatal myelomeningocele repair: a National Surgical Quality Improvement Program Pediatric database analysis. (27258591)
2016
42
Bone Mineral Content in Infants With Myelomeningocele, With and Without Treadmill Stepping Practice. (27088680)
2016
43
Does shunt selection affect the rate of early shunt complications in neonatal myelomeningocele-associated hydrocephalus? -a multi-center report. (27593850)
2016
44
The Management of Myelomeningocele Study: obstetrical outcomes and risk factors for obstetrical complications following prenatal surgery. (27496687)
2016
45
Prenatal myelomeningocele repair: Do bladders better? (27862250)
2016
46
Survey on Current Postnatal Surgical Management of Myelomeningocele in Germany. (27273605)
2016
47
Sequential morphological change of Chiari malformation type II following surgical repair of myelomeningocele. (26936599)
2016
48
Current Selection Criteria and Perioperative Therapy Used for Fetal Myelomeningocele Surgery. (26855109)
2016
49
Maternal gene-micronutrient interactions related to one-carbon metabolism and the risk of myelomeningocele among offspring. (27384413)
2016
50
Walking activity during daily living in children with myelomeningocele. (27384911)
2016

Variations for Myelomeningocele

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Expression for genes affiliated with Myelomeningocele

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Search GEO for disease gene expression data for Myelomeningocele.

Pathways for genes affiliated with Myelomeningocele

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Pathways related to Myelomeningocele according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CBS, MTHFR
29.4PAX3, SCRIB, VANGL1
3
Show member pathways
9.4CBS, MTHFR, MTR
4
Show member pathways
9.4MTHFR, MTRR
5
Show member pathways
9.1MTR, MTRR
69.1MTR, MTRR
7
Show member pathways
8.9DACT1, PRICKLE1, SCRIB, VANGL2
8
Show member pathways
8.8CBS, MTR, MTRR
9
Show member pathways
8.3MTHFD1, MTHFR, MTR, MTRR
10
Show member pathways
8.0CBS, MTHFD1, MTHFR, MTR, MTRR

GO Terms for genes affiliated with Myelomeningocele

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Cellular components related to Myelomeningocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058296.9CBS, DACT1, MTHFD1, MTHFR, MTR, MTRR

Biological processes related to Myelomeningocele according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1homocysteine metabolic processGO:005066710.6CBS, MTHFR
2apical protein localizationGO:004517610.4CELSR1, VANGL2
3establishment of body hair planar orientationGO:004810510.4CELSR1, VANGL2
4establishment of planar polarityGO:000173610.4CELSR1, VANGL2
5hair follicle developmentGO:000194210.4CELSR1, VANGL2
6lateral sprouting involved in lung morphogenesisGO:006049010.4CELSR1, VANGL2
7orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:006048810.4CELSR1, VANGL2
8planar cell polarity pathway involved in neural tube closureGO:009017910.3CELSR1, VANGL2
9planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:006048910.3CELSR1, VANGL2
10tetrahydrofolate interconversionGO:003599910.2MTHFD1, MTHFR
11post-anal tail morphogenesisGO:003634210.2T, VANGL2
12transsulfurationGO:001934610.2CBS, MTHFD1
13homocysteine catabolic processGO:004341810.1CBS, MTRR
14anterior/posterior pattern specificationGO:000995210.0CELSR1, T, VANGL2
15cobalamin metabolic processGO:00092359.8MTR, MTRR
16sulfur amino acid metabolic processGO:00000969.7MTR, MTRR
17folic acid metabolic processGO:00466559.5MTHFD1, MTHFR, MTRR
18methionine metabolic processGO:00065559.5MTHFD1, MTHFR, MTRR
19Wnt signaling pathway, planar cell polarity pathwayGO:00600719.4CELSR1, PRICKLE1, VANGL1, VANGL2
20wound healingGO:00420609.3CELSR1, SCRIB, VANGL2
21methionine biosynthetic processGO:00090869.2MTHFD1, MTR, MTRR
22oxidation-reduction processGO:00551149.1CBS, MTHFD1, MTHFR, MTRR
23neural tube closureGO:00018438.7CELSR1, MTHFD1, PRICKLE1, SCRIB, T, VANGL2

Molecular functions related to Myelomeningocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:007234110.8CBS, MTHFR
2NADP bindingGO:005066110.2MTHFR, MTRR
3protein bindingGO:00055155.2CBS, CELSR1, DACT1, MTHFD1, MTR, MTRR

Sources for Myelomeningocele

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet