Myelomonocytic Leukemia malady

MalaCards: Myelomonocytic Leukemia is related to juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. An important gene associated with Myelomonocytic Leukemia is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are ErbB2-ErbB3 Heterodimers and Colorectal cancer. The compounds vincristine and threonine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and myeloid, and related mouse phenotypes are other and respiratory system.

myelomonocytic leukemia 7 43

Diseases related to myelomonocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 492)

id	Related Disease	Score	Top Affiliating Genes
1	juvenile myelomonocytic leukemia	38.6	ARHGAP26, PTPN11, NF1
2	chronic myelomonocytic leukemia	37.0	MPO, JAK2, FLT3, ETV6, PTPN11, NF1
3	acute myelomonocytic leukemia	36.1	MPO, MLL, CBFB, ETV6, CREBBP, DNTT
4	myelodysplastic syndrome	31.7	KIR3DL1, RARA, RAN, BIRC5, MPO, JAK2
5	neurofibromatosis	30.9	RASA2, RAF1, RASA1, HRAS, PTPN11, NF1
6	myeloproliferative disorder	30.3	RAN, MPO, JAK2, MLL, FLT3, INPP5D
7	myelofibrosis	30.2	JAK2, IL3, CSF3
8	hodgkin's lymphoma	29.8	JAK2, MLL, FLT3, IL13, IL3, EZH2
9	leopard syndrome	29.5	BRAF, RAF1, CDKN3, HRAS, PTPN11, NF1
10	eosinophilia	28.5	MPO, JAK2, IL13, IL3, IL4, CBFB
11	immunodeficiency	27.8	KIR3DL1, CDKN3, IL13, IL4, CBL, CBLB
12	acute lymphocytic leukemia	27.6	RB1, MYC, RASA1, BIRC5, MPO, JAK2
13	non-hodgkin lymphoma	27.4	MYC, MYB, BIRC5, JAK2, CDK6, CDKN3
14	noonan syndrome	26.9	BRAF, RAF1, BIRC5, MPO, JUN, JAK2
15	chronic myeloid leukemia	24.3	KIR3DL1, MYC, MYB, RARA, RAF1, RAN
16	esophageal cancer	24.0	RB1, BRAF, MYC, RAN, BIRC5, MPO
17	leukemia	22.9	KIR3DL1, BTD, RB1, SEPT9, NACA, BRAF
18	osteosarcoma	22.5	RB1, NACA, MYC, RARA, RAN, BIRC5
19	lymphocytic leukemia	20.7	KIR3DL1, RB1, BRAF, MYC, MYB, RAF1
20	esophagitis	19.6	RB1, BRAF, MYC, RARA, RAF1, RAN
21	acute myeloid leukemia	19.2	RB1, SEPT9, BRAF, MYC, MYB, RASA2
22	myeloid leukemia	18.8	KIR3DL1, RB1, BRAF, MYC, MYB, RASA2
23	carcinoma	14.8	KIR3DL1, BTD, RB1, NACA, BRAF, MYC
24	bone marrow cancer	14.0	FLT3, IL3, NRAS, KRAS
25	acute megakaryoblastic leukemia	13.9	MPO, MLL, IL3, CSF2, RUNX1
26	acute myeloid leukemia, adult	13.9	JAK2, KRAS, RUNX1
27	stem cell leukemia	13.9	MPO, FLT3, RUNX1, GATA2
28	sm-ahnmd	13.9	JAK2, PDGFRA, PDGFRB, STAT5A
29	cyclic hematopoiesis	13.9	IL3, CSF1, CSF2, CSF3
30	hypereosinophilic syndrome	13.9	IL3, PDGFRA, PDGFRB, WT1
31	weaver syndrome	13.8	ASXL1, EZH2, NUP98
32	dyserythropoietic anemia with thrombocytopenia	13.8	IL3, CSF1, CSF2, CSF3
33	aplastic anemia	13.8	FLT3, IL3, CSF1, CSF2, CSF3, GATA2
34	leukemoid reaction	13.8	IL3, CSF2, CSF3
35	myeloid sarcoma	13.8	MPO, FLT3, NPM1, MYH11
36	chronic myeloproliferative disease	13.8	MPO, JAK2, FLT3, ETV6, PDGFRA, PDGFRB
37	alpha-thalassemia/mental retardation syndrome	13.7	ARHGAP26, CREBBP, WT1
38	granulocytopenia	13.7	IL3, TNF, CSF2, CSF3
39	pigmented villonodular synovitis	13.7	TP53, NF1, CSF1
40	chronic neutrophilic leukemia	13.7	MLL, CSF2, CSF3
41	pancytopenia	13.7	MLL, IL3, WT1, CSF1, CSF2, CSF3
42	choroid plexus carcinoma	13.6	TP53, PDGFRA, PDGFRB
43	cystic teratoma	13.6	CDKN3, TP53, PTEN, NRAS, CSF1
44	mastocytosis	13.6	RARA, MPO, JAK2, IL13, IL3, CBL
45	pulmonary alveolar proteinosis	13.6	IL3, TNF, CSF1, CSF2, CSF3, GATA2
46	severe congenital neutropenia	13.6	MPO, IL3, CSF2, CSF3
47	neurofibroma	13.6	RASA2, PTEN, SPRED1, NF1, PDGFRA, PDGFRB
48	lymphoproliferative syndrome	13.6	INPP5D, HRAS, PTPN11, NRAS, KRAS
49	felty's syndrome	13.6	IL3, CSF2, CSF3
50	newcastle disease	13.6	BIRC5, MX1, IRF1, TNF, PTPN11

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myelomonocytic leukemia:

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MGI Mouse Phenotypes related to myelomonocytic leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	other phenotype	MP:0005395	10.1	CSF1, PDGFRA, NF1, IL13, IRF2, JAK2
2	respiratory system phenotype	MP:0005388	10.0	MYH11, PRDM16, HIP1, NF1, SPRED1, CBL
3	craniofacial phenotype	MP:0005382	9.8	CSF2, MECOM, MLL, KAT6A, RASA1, HTT
4	limbs/digits/tail phenotype	MP:0005371	9.7	CBL, CBFB, MECOM, INPP5D, MLL, KAT6A
5	endocrine/exocrine gland phenotype	MP:0005379	9.7	GATA2, CDK6, HTT, ETV6, CSF1R, PRDM16
6	liver/biliary system phenotype	MP:0005370	9.3	RUNX1, MLL, KAT6A, MT1A, MYB, MECOM
7	pigmentation phenotype	MP:0001186	9.1	RB1, BRAF, MYC, CBL, TP53, PTEN
8	renal/urinary system phenotype	MP:0005367	8.8	MYH11, PDGFRB, BRAF, GATA2, KRAS, RARA
9	hearing/vestibular/ear phenotype	MP:0005377	8.6	MECOM, MLL, CDKN1A, RASA1, RARA, IL13
10	adipose tissue phenotype	MP:0005375	8.0	CSF2, RB1, BRAF, MYC, CDKN1A, CBL
11	no phenotypic analysis	MP:0003012	8.0	AIRE, TET2, RB1, PTPN3, PTPN11, HRAS
12	embryogenesis phenotype	MP:0005380	8.0	CBFB, NACA, BRAF, HTT, MECOM, MLL
13	digestive/alimentary phenotype	MP:0005381	7.9	MT1A, MYC, BRAF, RARA, RB1, MYH11
14	reproductive system phenotype	MP:0005389	7.5	CSF2, CSF1R, CSF1, STAT5A, DNMT3A, HIP1
15	hematopoietic system phenotype	MP:0005397	7.0	SIPA1, NRAS, SPRED1, CYCS, TET2, HOXA9
16	immune system phenotype	MP:0005387	7.0	WT1, AIRE, HOXA9, ETV6, EZH2, CBL
17	muscle phenotype	MP:0005369	6.9	RB1, BTD, NACA, MYH11, GAB2, CSF1
18	behavior/neurological phenotype	MP:0005386	6.9	BTD, CYCS, SPRED1, CREBBP, NF1, PDGFRA
19	normal phenotype	MP:0002873	6.5	GATA2, RUNX1, STAT5A, DNTT, HBG1, KRAS
20	tumorigenesis	MP:0002006	5.9	SIPA1, RUNX1, TET2, TNF, TP53, TRIM33
21	vision/eye phenotype	MP:0005391	5.7	NPM1, CSF1, SOS1, PRRX1, TNF, PTPN11
22	mortality/aging	MP:0010768	5.5	IRF1, RB1, MLL, CDKN1A, CDK6, JAK2
23	skeleton phenotype	MP:0005390	5.4	HIP1, INPP5D, IRF1, MLL, CDKN1A, JAK2
24	integument phenotype	MP:0010771	5.4	KAT6A, RAF1, MYB, MYC, BRAF, RB1
25	nervous system phenotype	MP:0003631	4.0	GATA2, NF1, CREBBP, SPRED1, CYCS, PTPN11
26	cardiovascular system phenotype	MP:0005385	3.9	CDKN1A, NACA, RB1, BRAF, MYC, CDK6
27	homeostasis/metabolism phenotype	MP:0005376	3.6	GATA2, RUNX1, CSF2, CSF1R, CSF1, SOS1
28	cellular phenotype	MP:0005384	2.7	CSF1R, CSF1, SOS1, NUP98, STAT5A, DNMT3A
29	growth/size phenotype	MP:0005378	2.2	STAT5A, PTPN11, PTPN3, PTEN, TET2, TNF

Articles related to myelomonocytic leukemia:

(show top 50)    (show all 124)

id	Title	Authors	Year	Affiliating Genes
1	Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia. (21784522)	Saito S.... Koike K.	2011	TP53
2	Transcription intermediary factor 1I^ is a tumor suppr essor in mouse and human chronic myelomonocytic leukemia. (21537084)	Aucagne R.... Delva L.	2011	TRIM33
3	Mutations of an E3 ubiquitin ligase c-Cbl but not TET 2 mutations are pathogenic in juvenile myelomonocytic leukemia. (20008299)	Muramatsu H.... Maciejewski J.P.	2010	PTPN11, CBL, NRAS
4	Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the pos sible presence of healthy persons with the mutations. (20595524)	Matsuda K.... Koike K.	2010	CBL
5	RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. (19282830)	Kuo M.C.... SHIH L.Y.	2009	RUNX1
6	TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. (19797729)	Kosmider O.... Solary E.	2009	TET2
7	Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases. (18818702)	Murati A.... Birnbaum D.	2009	MYB, KAT6A
8	Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation. (18784923)	Raepple D.... Scheele J.S.	2009	RASA1
9	Quantification of granulocyte-macrophage colony-stimulating factor hypersensitivity in juvenile myelomonocytic leukemia by 3H-thymidine assay. (18164384)	Tanaka M.... Kojima S.	2008	CSF2
10	Juvenile myelomonocytic leukemia with less aggressive clinical course and KRAS mutation. (18561174)	Imamura M.... Uchiyama M.	2008	KRAS
11	Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. (18287021)	Marcondes A.M.... Deeg H.J.	2008	IL32
12	Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia. (18024410)	de Vries A.C.... van den Heuvel-Eibrink M.M.	2007	BRAF
13	Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature. (17889707)	Zhang L.... Schreck R.	2007	NUP98, PRRX1
14	Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. (17353900)	Flotho C.... Niemeyer C.M.	2007	PTPN11, NF1
15	Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia. (17315019)	Kratz C.P.... Zenker M.	2007	SOS1
16	FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. (17936561)	Lee B.H.... Gilliland D.G.	2007	FLT3
17	Clinical and immunologic responses to very low-dose vaccination with WT1 peptide (5 microg/body) in a patient with chronic myelomonocytic leukemia. (17562620)	Kawakami M.... Sugiyama H.	2007	WT1
18	Unusual association of MLL rearrangement and secondary myelomonocytic leukemia in a 15-year-old patient treated for osteosarcoma. (17280715)	Brichard B.... Vermylen C.	2007	MLL
19	Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. (17332249)	Matsuda K.... Koike K.	2007	NRAS, KRAS
20	Activity of decitabine, a hypomethylating agent, in c hronic myelomonocytic leukemia. (17219444)	Aribi A.... Kantarjian H.	2007	TOP1
21	Survivin expression, apoptosis and proliferation in chronic myelomonocytic leukemia. (16529600)	Invernizzi R.... Ascari E.	2006	BIRC5
22	The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (15928039)	Kratz C.P.... Loh M.L.	2005	PTPN11
23	Mitogen-activated protein kinase pathway controls autoimmune regulator (AIRE) gene expression in granulo-monocyte colony stimulating factor (GM-CSF)-stimulated myelomonocytic leukemia OTC-4 cells. (15894121)	Nagafuchi S.... Shimizu N.	2005	AIRE
24	JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia. (16079889)	Tono C.... Ito E.	2005	JAK2
25	Activating FLT3 mutations are rare in children with juvenile myelomonocytic leukemia. (15390271)	Gratias E.J.... Emanuel P.D.	2005	FLT3
26	Viral infections in juvenile myelomonocytic leukemia: prevalence and clinical implications. (15454834)	Manabe A.... Nakahata T.	2004	MX1
27	Chronic myelomonocytic leukemia: myeloproliferative v ariant. (15087071)	Onida F.... Beran M.	2004	NRAS
28	Deletion of CBFB in a patient with acute myelomonocytic leukemia (AML M4Eo) and inversion 16. (15381374)	Egan N.... Cannell P.	2004	CBFB
29	Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. (12717436)	Tartaglia M.... Gelb B.D.	2003	PTPN11
30	Human herpesvirus 6 infection mimicking juvenile myelomonocytic leukemia in an infant. (11990701)	Lorenzana A.... Emanuel P.D.	2002	CSF2
31	A unique AML1 (CBF2A) rearrangement, t(1;21)(p32;q22), observed in a patient with acute myelomonocytic leukemia. (11566347)	Cherry A.M.... Natkunam Y.	2001	RUNX1
32	Trisomy 11 and a complex t(11;11;22) in a patient with acute myelomonocytic leukemia (AML-M4) following myelodysplasia (MDS): a cytogenetic study of a mechanism of leukemogenesis. (10640142)	Bernasconi P.... Bernasconi C.	2000	MLL
33	A novel variant of acute myelomonocytic leukemia carrying t(3;12)(q26;p13) with characteristics of 3q21q26 syndrome. (9695409)	Iwase S.... Yamada H.	1998	MECOM
34	Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (9834234)	Frankel A.E.... Eaves C.	1998	CSF2
35	Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937). (9615391)	Vrana J.A.... Grant S.	1998	CDK2, DYT10
36	Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells. (9770354)	Wang Z.... Grant S.	1998	MYC, CDK2, CDKN1A
37	Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. (9639526)	Side L.E.... Shannon K.M.	1998	NF1
38	EVI-1 gene expression in myeloid clonogenic cells from juvenile myelomonocytic leukemia (JMML). (9447818)	Privitera E.... Biondi A.	1997	RUNX1
39	Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16)(q23;p13) chromosome translocation. (9290955)	Satake N.... Kaneko Y.	1997	CREBBP, KAT6A
40	Interleukin (IL)-10, but not IL-4 or IL-13, inhibits cytokine production and growth in juvenile myelomonocytic leukemia cells. (9012477)	Iversen P.O.... Lopez A.F.	1997	IL13
41	Interleukin 10 inhibits growth and granulocyte/macrophage colony-stimulating factor production in chronic myelomonocytic leukemia cells. (8879210)	Geissler K.... Lechner K.	1996	IL3, CSF1
42	Extramedullary myeloid cell tumors arising in the set ting of chronic myelomonocytic leukemia. A report of two cases. (8554447)	Elenitoba-Johnson K.... Medeiros L.J.	1996	MPO
43	Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (8168137)	Golub T.R.... Gilliland D.G.	1994	ETV6
44	Acute myelomonocytic leukemia with t(10;11)(p13;q23): heterogeneity of breakpoints at 11q23 and association with recombinase activation. (7529550)	Height S.E.... Catovsky D.	1994	MLL
45	Philadelphia chromosome (Ph1) positive acute myelomonocytic leukemia with esophageal cancer: a case report (1507418)	Hara M.... Hoshijima T.	1992	MPO
46	Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. The Groupe FranAsais de CytogAcnActique HAcmatologique. (2070054)	Martiat P.... Rodhain J.	1991	NRAS
47	Interleukin 4 suppresses the spontaneous growth of ch ronic myelomonocytic leukemia cells. (2056118)	Akashi K.... Niho Y.	1991	IL4
48	M-CSF and M-CSF-receptor gene expression in acute myelomonocytic leukemias. (2154646)	Parwaresch M.R.... Radzun H.J.	1990	CSF1R, IL3, CSF1
49	The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia. (2303255)	Sutherland G.R.... West A.K.	1990	MT1A
50	RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia. (2205309)	Hirsch-Ginsberg C.... Stass S.A.	1990	RAN

Genes related to myelomonocytic leukemia according to GeneCards:

(show top 50)    (show all 97)

id	Symbol	Description	Score	GeneCards Section Context
1	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	11.1	Publications, Summaries
2	NF1	neurofibromin 1	11.1	Publications, Summaries, Functions
3	ASXL1	additional sex combs like 1 (Drosophila)	11.1	Publications, Summaries
4	SPECC1	sperm antigen with calponin homology and coiled-coil domains 1	11.1	Publications, Summaries
5	ARHGAP26	Rho GTPase activating protein 26	11.1	Summaries
6	SARNP	SAP domain containing ribonucleoprotein	11.1	Summaries, Publications
7	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0	Publications
8	RUNX1	runt-related transcription factor 1	11.0	Publications
9	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	11.0	Summaries
10	SEPT9	septin 9	11.0	Summaries, Publications
11	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
12	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
13	FLT3	fms-related tyrosine kinase 3	11.0	Publications
14	KAT6A	K(lysine) acetyltransferase 6A	11.0	Publications
15	TET2	tet methylcytosine dioxygenase 2	11.0	Publications
16	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
17	NUP98	nucleoporin 98kDa	11.0	Publications
18	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications
19	MPO	myeloperoxidase	11.0	Publications
20	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
21	RARA	retinoic acid receptor, alpha	11.0	Publications
22	JAK2	Janus kinase 2	11.0	Publications
23	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0
24	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
25	CDKN3	cyclin-dependent kinase inhibitor 3	11.0
26	SIPA1	signal-induced proliferation-associated 1	11.0	Publications
27	USP16	ubiquitin specific peptidase 16	11.0	Publications
28	DEFA3	defensin, alpha 3, neutrophil-specific	11.0	Publications
29	NACA	nascent polypeptide-associated complex alpha subunit	11.0	Publications
30	IL32	interleukin 32	11.0	Publications
31	DEFA1	defensin, alpha 1	11.0	Publications
32	HOXA9	homeobox A9	11.0	Publications
33	RAB4A	RAB4A, member RAS oncogene family	11.0	Publications
34	PRRX1	paired related homeobox 1	11.0	Publications
35	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	11.0	Publications
36	HBG1	hemoglobin, gamma A	11.0	Publications
37	GATA2	GATA binding protein 2	11.0
38	CBFB	core-binding factor, beta subunit	11.0	Publications
39	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
40	RAN	RAN, member RAS oncogene family	11.0	Publications
41	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
42	TRIM33	tripartite motif containing 33	11.0	Publications
43	RABEP1	rabaptin, RAB GTPase binding effector protein 1	11.0	Publications
44	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
45	HIP1	huntingtin interacting protein 1	11.0	Publications
46	SPRED1	sprouty-related, EVH1 domain containing 1	11.0	Publications
47	CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase	11.0	Publications
48	BTD	biotinidase	11.0	Publications
49	RASA2	RAS p21 protein activator 2	11.0	Publications
50	IRF2	interferon regulatory factor 2	11.0	Publications

Pathways related to myelomonocytic leukemia according to GeneDecks:

(show top 50)    (show all 245)

id	Pathway	Score	Top Affiliating Genes
1	ErbB2-ErbB3 Heterodimers36	10.6	RAF1, SOS1
2	Colorectal cancer20	10.5	BRAF
3	Adipocytokines & Insulin Signaling37	10.5	KRAS, PTPN11, CBL, BRAF, SOS1
4	Development_EPO-induced Jak-STAT pathway41	10.1	JAK2, CBL, STAT5A, RASA1, MYC
5	Pathway_PA16595942534	10.1	BRAF, RAF1, HRAS, NRAS, KRAS, FLT3
6	Non-small cell lung cancer20	9.9	RB1, HRAS, NRAS, CDK6, KRAS, SOS1
7	Development_EGFR signaling via small GTPases41	9.7	MYC, RAF1, CBL, HRAS
8	Development EPO-induced Jak-STAT pathway10	9.6	STAT5A, PTPN11, HRAS, CBL, JAK2, RASA1
9	Immune response IL-3 activation and signaling pathway10	9.4	RAF1, JUN, JAK2, INPP5D, IL3, HRAS
10	Immune response_IL-3 activation and signaling pathway41	9.4	INPP5D, SOS1, STAT5A, PTPN11, HRAS, IL3
11	Development EGFR signaling via small GTPases10	9.4	MYC, RAF1, CBL, HRAS, NRAS, KRAS
12	Development EPO-induced MAPK pathway10	9.4	RAF1, JUN, JAK2, INPP5D, CBL, SOS1
13	Development_EPO-induced MAPK pathway41	9.3	KRAS, NRAS, HRAS, CBL, INPP5D, JAK2
14	Development_Flt3 signaling41	9.3	SOS1, FLT3, STAT5A, PTPN11, HRAS, INPP5D
15	IL-3 Pathway36	9.3	STAT5A, JUN, NRAS, HRAS, BRAF, SOS1
16	Acute myeloid leukemia20	9.2	FLT3, BRAF, MYC, RARA, RAF1, RUNX1
17	Pathway_PA16598005034	9.2	KRAS, PDGFRA, NRAS, HRAS, BRAF, PDGFRB
18	Development Flt3 signaling10	9.2	PTPN11, RAF1, GAB2, JUN, FLT3, INPP5D
19	Fc epsilon RI signaling pathway20	9.1	HRAS, IL4, TNF, NRAS, KRAS, SOS1
20	Thrombopoietin Pathway36	9.1	SOS1, STAT5A, NRAS, HRAS, JAK2, JUN
21	Hematopoietic cell lineage20	9.1	FLT3, IL3, IL4, ANPEP, TNF, DNTT
22	PDGF Pathway36	9.0	RAF1, JAK2, STAT5A, SOS1, PDGFRB, PDGFRA
23	Endometrial cancer20	8.9	SOS1, KRAS, NRAS, PTEN, TP53, HRAS
24	EGF Pathway36	8.9	RAF1, RASA1, JUN, JAK2, NRAS, HRAS
25	Renal cell carcinoma20	8.9	NRAS, RAF1, JUN, HRAS, CREBBP, SOS1
26	IL-6 Pathway36	8.8	CSF2, CSF1, NRAS, HRAS, IL4, IL3
27	Akt Signaling36	8.8	IL4, CSF2, NRAS, TNF, CCND1, FLT3
28	Prolactin Signaling36	8.8	BRAF, MYC, RAF1, JUN, JAK2, HRAS
29	Glioblastoma Multiforme36	8.7	SOS1, PDGFRB, PDGFRA, NF1, NRAS, PTEN
30	Melanoma20	8.6	RB1, CDK6, RAF1, BRAF, CDKN1A, CCND1
31	Glioma20	8.5	HRAS, CCND1, CDKN1A, CDK6, RAF1, BRAF
32	Bladder cancer20	8.5	RAF1, NRAS, TP53, CCND1, HRAS, CDKN1A
33	Pancreatic Adenocarcinoma36	8.5	JAK2, PDGFRB, SOS1, STAT5A, FLT3, PDGFRA
34	Development_Prolactin receptor signaling41	8.5	STAT5A, SOS1, MYC, RAF1, CREBBP, PTPN11
35	Development Prolactin receptor signaling10	8.4	SOS1, STAT5A, MYC, RAF1, CREBBP, PTPN11
36	T cell receptor signaling pathway20	8.4	CSF2, SOS1, KRAS, NRAS, TNF, HRAS
37	MAPK signaling pathway20	8.4	PDGFRB, KRAS, PDGFRA, NF1, NRAS, SOS1
38	ErbB signaling pathway20	8.4	SOS1, BRAF, MYC, RAF1, JUN, CDKN1A
39	TRKA Signaling36	8.4	SOS1, BRAF, MYC, RAF1, HRAS, TP53
40	Jak-STAT signaling pathway20	8.3	IL3, IL13, JAK2, MYC, PTPN11, CBLB
41	Prostate cancer20	8.2	SOS1, KRAS, PDGFRB, PDGFRA, CREBBP, NRAS
42	Development_Thrombopoietin-regulated cell processes41	8.0	MYC, HRAS, BRAF, RAF1, BIRC5, JUN
43	Development Thrombopoietin-regulated cell processes10	8.0	BRAF, JUN, SOS1, MYC, RAF1, BIRC5
44	STAT3 Pathway36	7.9	JAK2, BRAF, MYC, RAF1, CDKN1A, CSF3
45	JAK-STAT Pathway36	7.9	SOS1, CSF1R, PDGFRB, PDGFRA, CREBBP, RAF1
46	Endothelin-1 Signaling Pathway36	7.8	TNF, JUN, IL13, IL3, IL4, HRAS
47	Chronic myeloid leukemia20	7.6	TP53, PTPN11, NRAS, KRAS, STAT5A, SOS1
48	ERK Signaling36	7.4	RAF1, SOS1, CSF1, CSF1R, BRAF, CSF2
49	Pathways in cancer20	6.9	STAT5A, KRAS, PDGFRA, CREBBP, NRAS, CYCS
50	Molecular Mechanisms of Cancer36	6.5	PTEN, TP53, HRAS, CBL, CCND1, IL3

Compounds related to myelomonocytic leukemia according to GeneDecks:

(show top 50)    (show all 277)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.5	MLL, CSF2
2	threonine32	10.3	RAF1, CDK6, MLL, FLT3, ANPEP, WT1
3	pge232	10.1	RAF1, IRF1, IL13, PTPN3
4	h2o232	10.0	MYB, RAN, MPO, JAK2, CDKN3, IL13
5	estrogen32	9.8	RARA, RAF1, ANXA2, HRAS, PTPN3, NF1
6	rapamycin32 42	10.3	RB1, BRAF, MYB, RAF1, JAK2, CDK6
7	agar32	9.1	RB1, BRAF, RARA, BIRC5, JAK2, CDK2
8	phosphotyrosine32	8.9	KIR3DL1, RASA2, RAF1, RASA1, JAK2, CDK2
9	cysteine32	8.9	BTD, MYB, RARA, RAF1, RAN, ANXA2
10	12-o-tetradecanoylphorbol 13-acetate32	8.8	RB1, BRAF, MYC, RARA, RAF1, JAK2
11	bryostatin 132	8.5	MYC, BIRC5, CDKN1A, CDK2, IL3, DYT10
12	5fluorouracil32	8.4	RB1, BIRC5, MPO, CDKN1A, CDK2, IL3
13	hydroxyurea32 9 9	10.4	MYC, JAK2, CDKN1A, CDK2, IL13, IL3
14	sb 20358032 42	9.2	RB1, BRAF, BIRC5, CDKN1A, IRF1, IL13
15	doxorubicin32 34 9 9	11.0	MYB, RAF1, CDK2, MLL, FLT3, IL13
16	depsipeptide32	8.0	RB1, BRAF, MYC, RAF1, CDKN1A, IL3
17	cytarabine32 34 9 9	10.9	RB1, MYC, MPO, JUN, CDKN1A, CDK2
18	chloramphenicol32 9 9	9.9	MYC, MYB, RARA, RAF1, MX1, MPO
19	zinc32 18	8.7	KIR3DL1, BTD, RB1, MYB, RARA, RAN
20	alanine32	7.7	BTD, BRAF, MYC, MYB, RARA, RAF1
21	lipid32	7.6	KIR3DL1, RB1, BRAF, MYB, RASA2, RARA
22	ly29400232	7.6	RARA, JUN, CDKN3, INPP5D, IL13, IL4
23	progesterone32 42 9 18 9	11.4	RB1, BRAF, MYB, RARA, BIRC5, CDKN1A
24	atp32	7.4	KIR3DL1, RB1, BRAF, RAN, BIRC5, MX1
25	vegf32	7.2	BRAF, MYC, RAF1, MPO, JAK2, CDKN1A
26	arsenite32 18	8.2	MYC, RARA, BIRC5, JUN, JAK2, CDK6
27	etoposide32 42 9 9	10.1	RB1, MYC, RARA, BIRC5, JUN, CDKN1A
28	calcitriol32 42 9 18 9	11.1	RB1, MYC, RARA, JUN, CDKN1A, CDK2
29	phosphoinositide32	7.1	BRAF, RARA, RAF1, BIRC5, JUN, JAK2
30	wortmannin32 42	7.9	BRAF, RAF1, BIRC5, JUN, JAK2, CDKN1A
31	lactacystin32	6.8	MYC, RAF1, BIRC5, JUN, JAK2, CDKN1A
32	herbimycin a32 42	7.7	MYC, RAF1, JUN, JAK2, CDK6, CDK2
33	paraffin32	6.7	RB1, BRAF, MYC, RARA, BIRC5, MPO
34	15-deoxy-delta-12,14-prostaglandin j232	6.7	MYC, BIRC5, JUN, JAK2, CDKN1A, CDK2
35	imatinib32 34 9 9	9.6	BRAF, MYC, MYB, RARA, RAF1, BIRC5
36	oxygen32 18	7.4	RB1, MYB, RAN, BIRC5, MT1A, MPO
37	cisplatin32 34 9 9	9.4	RB1, BRAF, MYC, RAF1, RAN, BIRC5
38	paclitaxel32 34 9 9	9.4	RB1, BRAF, MYC, RARA, RAF1, BIRC5
39	dexamethasone32 42 34 9 9	10.4	RB1, MYC, MYB, RARA, RAF1, BIRC5
40	genistein32 9 18 9	9.3	RB1, MYC, RAF1, BIRC5, JUN, JAK2
41	oligonucleotide32	6.1	KIR3DL1, RB1, BRAF, MYC, MYB, RARA
42	actinomycin d32	5.7	RB1, MYC, MYB, RARA, BIRC5, JUN
43	butyrate32	5.6	RB1, MYC, MYB, RARA, RAF1, BIRC5
44	pd 98,05932	5.5	RB1, BRAF, MYC, RARA, RAF1, BIRC5
45	phosphatidylinositol32	5.5	RB1, BRAF, MYC, RASA2, RARA, RAF1
46	thymidine32 18	6.3	RB1, MYC, MYB, RARA, RAF1, BIRC5
47	cycloheximide32	4.5	MYC, MYB, RARA, RAF1, BIRC5, MX1
48	retinoic acid32 42 18	5.8	RB1, BRAF, MYC, MYB, RARA, RAF1
49	serine32	2.9	BTD, RB1, BRAF, MYC, MYB, RARA
50	tyrosine32	2.6	KIR3DL1, BTD, RB1, BRAF, MYC, MYB

Cellular components related to myelomonocytic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	8.7	CDKN1A, CDK2, CCND1, CDK6
2	nucleolus	GO:005730	8.2	DNMT3A, DNTT, TOP1, WT1, SPRED1, AIRE
3	nucleoplasm	GO:005654	6.6	NUP98, CREBBP, WT1, TOP1, CDKN1A, STAT5A
4	cytosol	GO:005829	5.5	JAK2, CDK6, CDKN1A, CDK2, IRF2, ARHGAP26
5	cytoplasm	GO:005737	5.5	SPRED1, USP16, PDGFRA, NF1, CREBBP, WT1
6	nucleus	GO:005634	4.1	GATA2, SPECC1, SPRED1, CYCS, PTEN, TP53

Biological processes related to myelomonocytic leukemia according to GeneDecks:

(show all 48)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	10.7	JAK2, RAF1, NRAS
2	myeloid cell differentiation	GO:030099	10.7	KAT6A, CBFB, TET2, RUNX1
3	embryonic hemopoiesis	GO:035162	10.7	MLL, IL3, RUNX1, KAT6A
4	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.7	JAK2, FLT3, PDGFRA, PDGFRB, CBL
5	peptidyl-tyrosine phosphorylation	GO:018108	10.7	STAT5A, CSF1R, FLT3, PDGFRB, PDGFRA, JAK2
6	negative regulation of granulocyte differentiation	GO:030853	10.6	RUNX1, PRDM16, RARA
7	regulation of synaptic transmission, GABAergic	GO:032228	10.6	KRAS, HRAS, NRAS, NF1
8	positive regulation of Rac protein signal transduction	GO:035022	10.5	NRAS, HRAS, KRAS
9	regulation of long-term neuronal synaptic plasticity	GO:048169	10.4	HRAS, NRAS, NF1, KRAS
10	visual learning	GO:008542	10.4	HTT, NRAS, NF1, KRAS, HRAS
11	cellular response to cytokine stimulus	GO:071345	10.4	IL13, CSF1R, FLT3
12	striated muscle cell differentiation	GO:051146	10.4	HRAS, KRAS, RB1, NRAS
13	cytokine-mediated signaling pathway	GO:019221	10.3	CSF1R, NUP98, STAT5A, KRAS, IRF1, PTPN11
14	osteoclast differentiation	GO:030316	10.3	TNF, CSF1, CSF1R, GAB2
15	positive regulation of MAP kinase activity	GO:043406	10.2	KRAS, PDGFRB, TNF, FLT3
16	leukocyte migration	GO:050900	10.2	PTPN11, INPP5D, HRAS, NRAS, KRAS, SOS1
17	positive regulation of survival gene product expression	GO:045885	10.2	CSF2, IL3, STAT5A
18	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	CSF1R, PDGFRB, TNF, HRAS, BRAF, PDGFRA
19	epidermal growth factor receptor signaling pathway	GO:007173	10.1	SOS1, KRAS, CBL, PTEN, PTPN11, HRAS
20	phosphatidylinositol-mediated signaling	GO:048015	10.0	PDGFRB, GAB2, CSF1R, PDGFRA, PTEN
21	social behavior	GO:035176	10.0	KRAS, PTEN, HRAS, HTT
22	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	BRAF, SOS1, KRAS, PTPN11, PTEN, HRAS
23	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	IL4, CSF2, IL3, JAK2
24	small GTPase mediated signal transduction	GO:007264	9.9	KRAS, RAB4A, SOS1, BRAF, NRAS, HRAS
25	nerve growth factor receptor signaling pathway	GO:048011	9.9	BRAF, RAF1, HRAS, PTEN, NRAS, KRAS
26	positive regulation of DNA replication	GO:045740	9.9	CSF2, HRAS, IL3, JUN, PDGFRA
27	virus-host interaction	GO:019048	9.9	NPM1, NUP98, RB1, NACA, CREBBP, PDGFRA
28	dendritic cell differentiation	GO:097028	9.8	CSF2, IL4, FLT3
29	MAPK cascade	GO:000165	9.8	NF1, KRAS, NRAS, TNF, HRAS, RAF1
30	mitotic cell cycle G1/S transition DNA damage checkpoint	GO:031571	9.8	CDK2, CCND1, TP53
31	negative regulation of neuron apoptotic process	GO:043524	9.6	NRAS, KRAS, BRAF, RASA1, JUN, HTT
32	positive regulation of protein phosphorylation	GO:001934	9.5	CCND1, KRAS, CSF1R, TNF, HRAS
33	blood coagulation	GO:007596	9.4	INPP5D, IRF2, IRF1, CDK2, JAK2, RAF1
34	signal transduction	GO:007165	9.4	HRAS, CREBBP, CBLB, RAF1, RARA, RAN
35	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.2	MYC, DNMT3A, WT1, CREBBP, TNF, TP53
36	Ras protein signal transduction	GO:007265	9.2	TP53, HRAS, CDK2, KRAS, SOS1, RB1
37	positive regulation of fibroblast proliferation	GO:048146	9.1	PDGFRA, JUN, CDKN1A, MYC, CDK6
38	immune response	GO:006955	9.1	IL4, CSF3, CSF2, KIR3DL1, CBLB, IL13
39	cell cycle arrest	GO:007050	9.1	IRF1, CDKN3, CDK6, HRAS, TP53, CDKN1A
40	induction of apoptosis by intracellular signals	GO:008629	9.0	MYC, CYCS, TP53, HRAS, CDKN1A
41	positive regulation of cell proliferation	GO:008284	8.9	NRAS, PTEN, MYC, RARA, BIRC5, JAK2
42	apoptotic process	GO:006915	8.8	TP53, TNF, PTEN, HIP1, SOS1, CYCS
43	negative regulation of cell proliferation	GO:008285	8.3	NPM1, PTEN, TNF, HRAS, FLT3, IRF1
44	transcription, DNA-dependent	GO:006351	8.2	BIRC5, USP16, SARNP, KAT6A, ASXL1, IRF2
45	negative regulation of apoptotic process	GO:043066	8.1	CBL, CSF2, WT1, PTEN, TNF, TP53
46	negative regulation of transcription, DNA-dependent	GO:045892	8.0	JUN, MYB, RARA, KAT6A, RB1, IRF1
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	CREBBP, IRF1, MYC, GATA2, MYB, RARA
48	positive regulation of transcription, DNA-dependent	GO:045893	7.0	WT1, KAT6A, JUN, CDK2, MLL, MLLT11

Molecular functions related to myelomonocytic leukemia according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor-activated receptor activity	GO:005021	10.5	PDGFRB, FLT3, PDGFRA
2	regulatory region DNA binding	GO:000975	10.3	RUNX1, IRF2, IRF1
3	chromatin binding	GO:003682	9.7	TP53, AIRE, EZH2, MPO, RAN, TOP1
4	transcription coactivator activity	GO:003713	9.2	USP16, JUN, NPM1, RARA, PRDM16, CREBBP
5	cytokine activity	GO:005125	9.2	IL32, IL13, IL3, IL4, TNF, CSF1
6	protein homodimerization activity	GO:042803	9.1	BIRC5, JUN, MLL, FLT3, MECOM, PDGFRA
7	transcription factor binding	GO:008134	9.0	GATA2, RUNX1, TP53, JUN, KAT6A, RARA
8	protein heterodimerization activity	GO:046982	9.0	MYC, RARA, BIRC5, TP53, NPM1, RUNX1
9	sequence-specific DNA binding transcription factor activity	GO:003700	8.1	WT1, GATA2, RUNX1, PRRX1, IRF1, STAT5A
10	DNA binding	GO:003677	7.8	RB1, IRF2, TRIM33, TP53, TOP1, DNTT
11	protein binding	GO:005515	1.6	ASXL1, SEPT9, BRAF, MYC, MYB, RARA