Myelopathy, Htlv-1-Associated malady
Categories: Neuronal diseases, Infectious diseases, Rare diseases, Immune diseases
Aliases & Descriptions for Myelopathy, Htlv-1-Associated:
Orphanet epidemiological data:53
tropical spastic paraparesis:
Inheritance: Not applicable; Age of onset: Adult
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases, Immune diseases
NINDS:48 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus ? human T-cell lymphotrophic virus type 1 (also known as HTLV-1) ? and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.
MalaCards based summary: Myelopathy, Htlv-1-Associated, also known as tropical spastic paraparesis, is related to tropical spastic paraparesis and htlv-1 associated myelopathy/tropical spastic paraparesis, and has symptoms including myelopathy, spastic paraparesis and abnormal pyramidal signs. An important gene associated with Myelopathy, Htlv-1-Associated is CNTN2 (Contactin 2). Affiliated tissues include t cells, skin and lung.
Description from OMIM:51 159580
UMLS symptoms related to Myelopathy, Htlv-1-Associated:hemiparesis, hemiplegia, paresis, paraparesis, todd paralysis, quadriparesis, monoparesis, paresis anal sphincter
Drugs for Myelopathy, Htlv-1-Associated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 43)
Interventional clinical trials:(show all 19)
Search NIH Clinical Center for Myelopathy, Htlv-1-Associated
MalaCards organs/tissues related to Myelopathy, Htlv-1-Associated:35
T cells, Skin, Lung, Eye, Brain, Nk cells
Search GEO for disease gene expression data for Myelopathy, Htlv-1-Associated.
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet