MCID: MYL002
MIFTS: 32

Myelophthisic Anemia

Categories: Blood diseases

Aliases & Classifications for Myelophthisic Anemia

MalaCards integrated aliases for Myelophthisic Anemia:

Name: Myelophthisic Anemia 12 14
Myelophthisis 12 69
Anemia, Leukoerythroblastic 12
Anemia Leukoerythroblastic 12
Leukoerythroblastic Anemia 69
Leukoerythroblastosis 12
Anemia, Myelophthisic 41

Classifications:



External Ids:

Disease Ontology 12 DOID:2354
ICD10 32 D61.82
MeSH 41 D000750
NCIt 46 C36218
SNOMED-CT 64 2694001

Summaries for Myelophthisic Anemia

Disease Ontology : 12 An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas.

MalaCards based summary : Myelophthisic Anemia, also known as myelophthisis, is related to basal cell carcinoma 1 and basal cell carcinoma. An important gene associated with Myelophthisic Anemia is JAK2 (Janus Kinase 2), and among its related pathways/superpathways are Immune response IL-2 activation and signaling pathway and Development EPO-induced Jak-STAT pathway. Affiliated tissues include bone marrow, bone and prostate.

Wikipedia : 72 Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases... more...

Related Diseases for Myelophthisic Anemia

Graphical network of the top 20 diseases related to Myelophthisic Anemia:



Diseases related to Myelophthisic Anemia

Symptoms & Phenotypes for Myelophthisic Anemia

Drugs & Therapeutics for Myelophthisic Anemia

Search Clinical Trials , NIH Clinical Center for Myelophthisic Anemia

Cochrane evidence based reviews: anemia, myelophthisic

Genetic Tests for Myelophthisic Anemia

Anatomical Context for Myelophthisic Anemia

MalaCards organs/tissues related to Myelophthisic Anemia:

38
Bone Marrow, Bone, Prostate, Skin, Pancreas, Breast

Publications for Myelophthisic Anemia

Articles related to Myelophthisic Anemia:

(show all 19)
# Title Authors Year
1
An elderly man with hemolysis and myelophthisic anemia. ( 28697949 )
2017
2
Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia. ( 23147353 )
2013
3
Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. ( 20672367 )
2010
4
Familial hypercholesterolemia with unusual foamy histiocytes. Report of a case with myelophthisic anemia and xanthoma of the maxillary sinus. ( 3354509 )
1988
5
Giant basal cell carcinoma with metastases and myelophthisic anemia. ( 3784556 )
1986
6
Metastatic basal cell carcinoma of the skin. Metastasis to the skeletal system producing myelophthisic anemia. ( 7142473 )
1982
7
Liposarcoma metastatic to bone marrow presenting as myelophthisic anemia: a case report. ( 7351015 )
1980
8
Sarcoma with myelophthisic anemia: report of two cases. ( 723797 )
1978
9
Diminished bone marrow responsiveness to erythropoietin in myelophthisic anemia. ( 1260653 )
1976
10
Acute myelomonocytic leukemia manifested as myelophthisic anemia in a dog. ( 1066343 )
1976
11
Metastasizing basal cell carcinoma of the skin with myelophthisic anemia. ( 5212310 )
1968
12
Myelophthisic anemia resulting from carcinoma of the pancreas: a case report. ( 6040711 )
1967
13
Primary myelofibrosis. (normocytic myelophthisic anemia). Review and case presentation. ( 13704495 )
1961
14
Myelophthisic anemia in cancer of the breast. ( 14376412 )
1955
15
Myelophthisic anemia as terminal stage of polycythemia vera; protracted x-ray treatment followed by a myelosclerotic syndrome. ( 14932790 )
1952
16
Metastases in bone marrow and myelophthisic anemia from carcinoma of the prostate. ( 18137147 )
1949
17
Carcinoma of stomach with myelophthisic anemia and thrombocytopenia. ( 18870550 )
1948
18
Myelophthisic anemia the presenting manifestation of prostatic carcinoma with skeletal metastases; the effect of castration and stilbestrol. ( 18101771 )
1948
19
The effect of castration and di-ethyl stilboestrol in a patient with myelophthisic anemia secondary to carcinoma of the prostate. ( 20272558 )
1947

Variations for Myelophthisic Anemia

Expression for Myelophthisic Anemia

Search GEO for disease gene expression data for Myelophthisic Anemia.

Pathways for Myelophthisic Anemia

Pathways related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.56 JAK2 PTPN11
2
Show member pathways
11.5 JAK2 PTPN11
3
Show member pathways
11.43 JAK2 PTPN11
4 11.36 JAK2 PTPN11
5 11.3 JAK2 PTPN11
6
Show member pathways
11.27 JAK2 PTPN11
7
Show member pathways
11.2 JAK2 PTPN11
8 11.05 JAK2 PTPN11
9
Show member pathways
10.99 JAK2 PTPN11
10
Show member pathways
10.93 JAK2 PTPN11
11 10.89 JAK2 PTPN11
12 10.76 JAK2 PTPN11
13 10.52 JAK2 PTPN11
14
Show member pathways
10.1 JAK2 PTPN11

GO Terms for Myelophthisic Anemia

Biological processes related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.16 EPHA3 PTPN11
2 platelet-derived growth factor receptor signaling pathway GO:0048008 8.96 JAK2 PTPN11
3 hormone-mediated signaling pathway GO:0009755 8.62 JAK2 PTPN11

Molecular functions related to Myelophthisic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.96 JAK2 PTPN11
2 peptide hormone receptor binding GO:0051428 8.62 JAK2 PTPN11

Sources for Myelophthisic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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