MCID: MYL015
MIFTS: 25

Myeloproliferative Disorder with Eosinophilia malady

Aliases & Classifications for Myeloproliferative Disorder with Eosinophilia

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Aliases & Descriptions for Myeloproliferative Disorder with Eosinophilia:

Name: Myeloproliferative Disorder with Eosinophilia 46 9
 
Myeloproliferative Disorder, Chronic, with Eosinophilia 46


External Ids:

OMIM46 131440

Summaries for Myeloproliferative Disorder with Eosinophilia

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MalaCards based summary: Myeloproliferative Disorder with Eosinophilia, also known as myeloproliferative disorder, chronic, with eosinophilia, is related to eosinophilia and pdgfrb-associated chronic eosinophilic leukemia, and has symptoms including autosomal dominant inheritance, myeloproliferative disorder and malignant eosinophil proliferation. An important gene associated with Myeloproliferative Disorder with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Pathways in cancer and Signaling by FGFR. The compounds dasatinib and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Description from OMIM:46 131440

Related Diseases for Myeloproliferative Disorder with Eosinophilia

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Graphical network of the top 20 diseases related to Myeloproliferative Disorder with Eosinophilia:



Diseases related to myeloproliferative disorder with eosinophilia

Symptoms for Myeloproliferative Disorder with Eosinophilia

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Symptoms by clinical synopsis from OMIM:

131440

Clinical features from OMIM:

131440

HPO human phenotypes related to Myeloproliferative Disorder with Eosinophilia:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 myeloproliferative disorder HP:0005547
3 malignant eosinophil proliferation HP:0006782

Drugs & Therapeutics for Myeloproliferative Disorder with Eosinophilia

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Drug clinical trials:

Search ClinicalTrials for Myeloproliferative Disorder with Eosinophilia

Search NIH Clinical Center for Myeloproliferative Disorder with Eosinophilia

Genetic Tests for Myeloproliferative Disorder with Eosinophilia

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Anatomical Context for Myeloproliferative Disorder with Eosinophilia

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MalaCards organs/tissues related to Myeloproliferative Disorder with Eosinophilia:

31
T cells

Animal Models for Myeloproliferative Disorder with Eosinophilia or affiliated genes

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Publications for Myeloproliferative Disorder with Eosinophilia

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Articles related to Myeloproliferative Disorder with Eosinophilia:

idTitleAuthorsYear
1
Congenital and childhood myeloproliferative disorders with eosinophilia responsive to imatinib. (22488677)
2012
2
Myeloproliferative disorder with eosinophilia and ETV6-ABL gene rearrangement: efficacy of second-generation tyrosine kinase inhibitors. (19394693)
2009
3
Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration. (10741923)
2000
4
Cytogenetic response induced by interferon alpha in the myeloproliferative disorder with eosinophilia, T cell lymphoma and the chromosomal translocation t(8;13)(p11;q12) (9639434)
1998
5
A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5). (8943895)
1996

Variations for Myeloproliferative Disorder with Eosinophilia

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Expression for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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Search GEO for disease gene expression data for Myeloproliferative Disorder with Eosinophilia.

Pathways for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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Compounds for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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Compounds related to Myeloproliferative Disorder with Eosinophilia according to GeneCards Suite gene sharing:

(show all 25)
idCompoundScoreTop Affiliating Genes
1dasatinib44 50 1111.7PDGFRB, BCR
2ganglioside449.7BCR, PDGFRB
3gp 130449.7BCR, PDGFRB
4inositol 1,4,5 trisphosphate449.6BCR, PDGFRB
5imatinib44 50 1111.6PDGFRB, BCR
6phenylalanine449.6BCR, PDGFRB
7phosphotyrosine449.5PDGFRB, BCR
8busulfan44 50 1111.5BCR, IFNA2
9rituximab44 50 1111.5BCR, IFNA2
10cytarabine44 50 1111.5BCR, IFNA2
11ly294002449.4PDGFRB, BCR
12cyclophosphamide44 50 1111.4BCR, IFNA2
13phosphoinositide449.4PDGFRB, BCR
14genistein44 28 60 1 24 1114.3BCR, PDGFRB
15leucine449.3PDGFRB, BCR
165fluorouracil449.3PDGFRB, IFNA2
17agar449.3IFNA2, PDGFRB
18ribonucleic acid449.2PDGFRB, IFNA2
19methionine449.2IFNA2, PDGFRB
20thymidine44 2410.0BCR, IFNA2
21oxygen44 249.9PDGFRB, BCR, IFNA2
22cysteine448.8PDGFRB, BCR, IFNA2
23lipid448.8PDGFRB, BCR, IFNA2
24tyrosine448.8IFNA2, BCR, PDGFRB
25cisplatin44 50 60 1111.7PDGFRB, IFNA2

GO Terms for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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Biological processes related to Myeloproliferative Disorder with Eosinophilia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein autophosphorylationGO:00467779.3PDGFRB, BCR
2platelet-derived growth factor receptor signaling pathwayGO:00480089.2PDGFRB, BCR
3peptidyl-tyrosine phosphorylationGO:00181089.0PDGFRB, BCR

Molecular functions related to Myeloproliferative Disorder with Eosinophilia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.3PDGFRB, BCR

Sources for Myeloproliferative Disorder with Eosinophilia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet