MCID: MYL015
MIFTS: 15

Myeloproliferative Disorder with Eosinophilia malady

Summaries for Myeloproliferative Disorder with Eosinophilia

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47OMIM, 33MalaCards
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MalaCards: Myeloproliferative Disorder with Eosinophilia is related to myeloproliferative disorder and pdgfrb-associated chronic eosinophilic leukemia. An important gene associated with Myeloproliferative Disorder with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Tyrosine Kinases / Adaptors and G-protein signaling H-RAS regulation pathway. The compounds 5fluorouracil and busulfan have been mentioned in the context of this disorder.

Description from OMIM:47 131440

Aliases & Classifications for Myeloproliferative Disorder with Eosinophilia

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47OMIM
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Aliases & Descriptions:

myeloproliferative disorder with eosinophilia 47


Related Diseases for Myeloproliferative Disorder with Eosinophilia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myeloproliferative Disorder with Eosinophilia:



Diseases related to myeloproliferative disorder with eosinophilia

Clinical Features for Myeloproliferative Disorder with Eosinophilia

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47OMIM
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Clinical features from OMIM:

131440

Clinical synopsis from OMIM:

131440

Drugs & Therapeutics for Myeloproliferative Disorder with Eosinophilia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Myeloproliferative Disorder with Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Myeloproliferative Disorder with Eosinophilia

Search NIH Clinical Center for Myeloproliferative Disorder with Eosinophilia

Search CenterWatch for Myeloproliferative Disorder with Eosinophilia

Genetic Tests for Myeloproliferative Disorder with Eosinophilia

Anatomical Context for Myeloproliferative Disorder with Eosinophilia

Animal Models for Myeloproliferative Disorder with Eosinophilia or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Myeloproliferative Disorder with Eosinophilia

Genetic Variations for Myeloproliferative Disorder with Eosinophilia

Expression for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloproliferative Disorder with Eosinophilia

Search GEO for disease gene expression data for Myeloproliferative Disorder with Eosinophilia.

Pathways for genes affiliated with Myeloproliferative Disorder with Eosinophilia

Sources:
4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0BCR, PDGFRB
2
G-protein signaling H-RAS regulation pathway
Hide members
9.0BCR, PDGFRB

Compounds for genes affiliated with Myeloproliferative Disorder with Eosinophilia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
15fluorouracil459.5PDGFRB, IFNA2
2busulfan45 1110.5BCR, IFNA2
3rituximab45 50 1111.4BCR, IFNA2
4agar459.4IFNA2, PDGFRB
5cytarabine45 50 1111.4BCR, IFNA2
6cyclophosphamide45 50 1111.4IFNA2, BCR
7dasatinib45 50 1111.4PDGFRB, BCR
8ganglioside459.3PDGFRB, BCR
9methionine459.3IFNA2, PDGFRB
10gp 130459.3PDGFRB, BCR
11inositol 1,4,5 trisphosphate459.2PDGFRB, BCR
12ribonucleic acid459.2PDGFRB, IFNA2
13imatinib45 50 1111.2PDGFRB, BCR
14phenylalanine459.1PDGFRB, BCR
15oxygen45 249.8PDGFRB, IFNA2, BCR
16cysteine458.8IFNA2, BCR, PDGFRB
17lipid458.7PDGFRB, IFNA2, BCR
18phosphotyrosine458.7PDGFRB, BCR
19tyrosine458.5BCR, PDGFRB, IFNA2

GO Terms for genes affiliated with Myeloproliferative Disorder with Eosinophilia

Sources:
16Gene Ontology
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Biological processes related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autophosphorylationGO:0467779.0BCR, PDGFRB
2platelet-derived growth factor receptor signaling pathwayGO:0480088.7BCR, PDGFRB

Molecular functions related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.0BCR, PDGFRB

Products for genes affiliated with Myeloproliferative Disorder with Eosinophilia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myeloproliferative Disorder with Eosinophilia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet