MCID: MYL015
MIFTS: 25

Myeloproliferative Disorder with Eosinophilia malady

Summaries for Myeloproliferative Disorder with Eosinophilia

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48OMIM, 34MalaCards
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MalaCards: Myeloproliferative Disorder with Eosinophilia is related to eosinophilia and myeloproliferative disorder. An important gene associated with Myeloproliferative Disorder with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Pathways in cancer and Signaling by FGFR. The compounds dasatinib and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Description from OMIM:48 131440

Aliases & Classifications for Myeloproliferative Disorder with Eosinophilia

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48OMIM
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Aliases & Descriptions:

myeloproliferative disorder with eosinophilia 48


Related Diseases for Myeloproliferative Disorder with Eosinophilia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Myeloproliferative Disorder with Eosinophilia:



Diseases related to myeloproliferative disorder with eosinophilia

Symptoms for Myeloproliferative Disorder with Eosinophilia

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48OMIM
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Symptoms by clinical synopsis from OMIM:

131440

Clinical features from OMIM:

131440

Drugs & Therapeutics for Myeloproliferative Disorder with Eosinophilia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Myeloproliferative Disorder with Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Myeloproliferative Disorder with Eosinophilia

Search NIH Clinical Center for Myeloproliferative Disorder with Eosinophilia

Search CenterWatch for Myeloproliferative Disorder with Eosinophilia

Genetic Tests for Myeloproliferative Disorder with Eosinophilia

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Anatomical Context for Myeloproliferative Disorder with Eosinophilia

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34MalaCards
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MalaCards organs/tissues related to Myeloproliferative Disorder with Eosinophilia:

34
T cells

Animal Models for Myeloproliferative Disorder with Eosinophilia or affiliated genes

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Publications for Myeloproliferative Disorder with Eosinophilia

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53PubMed
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Articles related to Myeloproliferative Disorder with Eosinophilia:

idTitleAuthorsYear
1
Congenital and childhood myeloproliferative disorders with eosinophilia responsive to imatinib. (22488677)
2012
2
Myeloproliferative disorder with eosinophilia and ETV6-ABL gene rearrangement: efficacy of second-generation tyrosine kinase inhibitors. (19394693)
2009
3
Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration. (10741923)
2000
4
Cytogenetic response induced by interferon alpha in the myeloproliferative disorder with eosinophilia, T cell lymphoma and the chromosomal translocation t(8;13)(p11;q12) (9639434)
1998
5
A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5). (8943895)
1996

Variations for Myeloproliferative Disorder with Eosinophilia

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Expression for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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Pathways for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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51PathCards, 31KEGG, 56Reactome, 61Thomson Reuters, 5Cell Signaling Technology
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Compounds for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1dasatinib46 52 1211.7PDGFRB, BCR
2ganglioside469.7BCR, PDGFRB
3gp 130469.7BCR, PDGFRB
4inositol 1,4,5 trisphosphate469.6BCR, PDGFRB
5imatinib46 52 1211.6PDGFRB, BCR
6phenylalanine469.6BCR, PDGFRB
7phosphotyrosine469.5PDGFRB, BCR
8busulfan46 52 1211.5BCR, IFNA2
9rituximab46 52 1211.5BCR, IFNA2
10cytarabine46 52 1211.5BCR, IFNA2
11ly294002469.4PDGFRB, BCR
12cyclophosphamide46 52 1211.4BCR, IFNA2
13phosphoinositide469.4PDGFRB, BCR
14genistein46 30 62 3 25 1214.3BCR, PDGFRB
15leucine469.3PDGFRB, BCR
165fluorouracil469.3PDGFRB, IFNA2
17agar469.3IFNA2, PDGFRB
18ribonucleic acid469.2PDGFRB, IFNA2
19methionine469.2IFNA2, PDGFRB
20thymidine46 2510.0BCR, IFNA2
21oxygen46 259.9PDGFRB, BCR, IFNA2
22cysteine468.8PDGFRB, BCR, IFNA2
23lipid468.8PDGFRB, BCR, IFNA2
24tyrosine468.8IFNA2, BCR, PDGFRB
25cisplatin46 52 62 1211.7PDGFRB, IFNA2

GO Terms for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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17Gene Ontology
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Biological processes related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autophosphorylationGO:0467779.3PDGFRB, BCR
2platelet-derived growth factor receptor signaling pathwayGO:0480089.2PDGFRB, BCR
3peptidyl-tyrosine phosphorylationGO:0181089.0PDGFRB, BCR

Molecular functions related to Myeloproliferative Disorder with Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3PDGFRB, BCR

Products for genes affiliated with Myeloproliferative Disorder with Eosinophilia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myeloproliferative Disorder with Eosinophilia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet