MCID: MYH009
MIFTS: 21

Myh7-Related Dilated Cardiomyopathy malady

Categories: Genetic diseases, Cardiovascular diseases, Rare diseases, Neuronal diseases, Ear diseases

Aliases & Classifications for Myh7-Related Dilated Cardiomyopathy

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Aliases & Descriptions for Myh7-Related Dilated Cardiomyopathy:

Name: Myh7-Related Dilated Cardiomyopathy 24
Cardiomyopathy, Dilated, 1s 68
 
Dilated Cardiomyopathy 1s 24
Cmd1s 24

Classifications:



Summaries for Myh7-Related Dilated Cardiomyopathy

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MalaCards based summary: Myh7-Related Dilated Cardiomyopathy, also known as cardiomyopathy, dilated, 1s, is related to cardiomyopathy, dilated, 1e and campomelic dysplasia. An important gene associated with Myh7-Related Dilated Cardiomyopathy is MYH7 (Myosin Heavy Chain 7), and among its related pathways are Dilated cardiomyopathy and Cardiac muscle contraction.

Related Diseases for Myh7-Related Dilated Cardiomyopathy

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Diseases in the Cardiomyopathy family:

Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1a
Cardiomyopathy, Dilated, 1v Cardiomyopathy, Dilated, 1d
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 1z Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1gg Cardiomyopathy, Dilated, 1l
Cardiomyopathy, Dilated, 1k Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1p Cardiomyopathy, Dilated, 1j
Cardiomyopathy, Dilated, 2b Cardiomyopathy, Dilated, 1q
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1t Cardiomyopathy, Dilated, 1ee
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1r
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff Cardiomyopathy, Dilated, 3b
Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Dilated Cardiomyopathy 1c Dilated Cardiomyopathy 1aa
Dilated Cardiomyopathy 1b Lmna-Related Dilated Cardiomyopathy
Cardiomyopathy Due to Anthracyclines Mypn-Related Cardiomyopathy
Abcc9-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Actn2-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Cryab-Related Dilated Cardiomyopathy
Csrp3-Related Dilated Cardiomyopathy Des-Related Dilated Cardiomyopathy
Dsg2-Related Dilated Cardiomyopathy Eya4-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Gatad1-Related Dilated Cardiomyopathy
Lama4-Related Dilated Cardiomyopathy Ldb3-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
myh7-related dilated cardiomyopathy Nexn-Related Dilated Cardiomyopathy
Pln-Related Dilated Cardiomyopathy Prdm16-Related Dilated Cardiomyopathy
Psen1-Related Dilated Cardiomyopathy Psen2-Related Dilated Cardiomyopathy
Rbm20-Related Dilated Cardiomyopathy Scn5a-Related Dilated Cardiomyopathy
Sdha-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Taz-Related Dilated Cardiomyopathy Tcap-Related Dilated Cardiomyopathy
Tmpo-Related Dilated Cardiomyopathy Tnnc1-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Tnnt2-Related Dilated Cardiomyopathy
Tpm1-Related Dilated Cardiomyopathy Ttn-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy

Diseases related to Myh7-Related Dilated Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy, dilated, 1e10.9
2campomelic dysplasia10.9
3cardiomyopathy, dilated, 1a10.9
4pervasive developmental disorder9.9MYH7, TPM1
5pfeiffer rockelein syndrome9.9MYH7, SCN5A
6mosaic trisomy 19.8MYH7, SCN5A
7retinitis pigmentosa 189.8MYH7, SCN5A
8long qt syndrome 99.8MYH7, TPM1
9xanthogranulomatous pyelonephritis9.8MYH7, SCN5A
10trs2-related diamond-blackfan anemia with mandibulofacial dysostosis9.7MYH7, SCN5A, TPM1
11ndp-related retinopathy of prematurity9.7MYH7, SCN5A, TPM1
12selenon-related myopathy9.7MYH7, SCN5A, TPM1
13sema4a-related retinitis pigmentosa9.7MYH7, SCN5A, TPM1
14sudden infant death syndrome9.7MYH7, SCN5A, TPM1
15tardbp-related frontotemporal dementia9.7MYH7, SCN5A, TPM1
16primary cutaneous gamma/delta-positive t-cell lymphoma9.7MYH7, SCN5A, TPM1
17pollen allergy9.7MYH7, SCN5A, TPM1
18cdkl5-related angelman-like syndrome9.7MYH7, SCN5A, TPM1
19emery-dreifuss muscular dystrophy, dominant type9.6MYH7, SCN5A, TPM1

Graphical network of diseases related to Myh7-Related Dilated Cardiomyopathy:



Diseases related to myh7-related dilated cardiomyopathy

Symptoms & Phenotypes for Myh7-Related Dilated Cardiomyopathy

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Drugs & Therapeutics for Myh7-Related Dilated Cardiomyopathy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Myh7-Related Dilated Cardiomyopathy

Genetic Tests for Myh7-Related Dilated Cardiomyopathy

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Genetic tests related to Myh7-Related Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Myh7-Related Dilated Cardiomyopathy24 MYH7

Anatomical Context for Myh7-Related Dilated Cardiomyopathy

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Publications for Myh7-Related Dilated Cardiomyopathy

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Variations for Myh7-Related Dilated Cardiomyopathy

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Clinvar genetic disease variations for Myh7-Related Dilated Cardiomyopathy:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MYH7NM_ 000257.3(MYH7): c.1594T> C (p.Ser532Pro)SNVPathogenicrs121913642GRCh37Chr 14, 23897088: 23897088
2MYH7NM_ 000257.3(MYH7): c.2710C> T (p.Arg904Cys)SNVPathogenicrs727503253GRCh37Chr 14, 23893328: 23893328
3TPM1NM_ 001018005.1(TPM1): c.688G> A (p.Asp230Asn)SNVPathogenicrs199476317GRCh37Chr 15, 63354462: 63354462
4SCN5ANM_ 198056.2(SCN5A): c.665G> A (p.Arg222Gln)SNVPathogenicrs45546039GRCh37Chr 3, 38655272: 38655272
5MYH7NM_ 000257.3(MYH7): c.1988G> A (p.Arg663His)SNVPathogenicrs371898076GRCh37Chr 14, 23896042: 23896042
6MYH7NM_ 000257.3(MYH7): c.5740G> A (p.Glu1914Lys)SNVLikely pathogenicrs397516254GRCh37Chr 14, 23883018: 23883018

Expression for genes affiliated with Myh7-Related Dilated Cardiomyopathy

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Search GEO for disease gene expression data for Myh7-Related Dilated Cardiomyopathy.

Pathways for genes affiliated with Myh7-Related Dilated Cardiomyopathy

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Pathways related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3MYH7, TPM1
29.3MYH7, TPM1
3
Show member pathways
8.5MYH7, SCN5A, TPM1

GO Terms for genes affiliated with Myh7-Related Dilated Cardiomyopathy

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Cellular components related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myofibrilGO:00300169.9MYH7, TPM1
2sarcomereGO:00300179.9MYH7, TPM1
3stress fiberGO:00017259.9MYH7, TPM1
4Z discGO:00300189.0MYH7, SCN5A

Biological processes related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:00069369.9MYH7, TPM1
2muscle filament slidingGO:00300499.8MYH7, TPM1
3regulation of heart rateGO:00020279.4MYH7, SCN5A
4ventricular cardiac muscle tissue morphogenesisGO:00550109.3MYH7, TPM1
5cardiac muscle contractionGO:00600489.1MYH7, SCN5A, TPM1

Molecular functions related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:00037799.9MYH7, TPM1
2calmodulin bindingGO:00055169.0MYH7, SCN5A

Sources for Myh7-Related Dilated Cardiomyopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet