MCID: MYH009
MIFTS: 20

Myh7-Related Dilated Cardiomyopathy malady

Genetic diseases, Cardiovascular diseases, Rare diseases, Muscle diseases categories

Aliases & Classifications for Myh7-Related Dilated Cardiomyopathy

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Aliases & Descriptions for Myh7-Related Dilated Cardiomyopathy:

Name: Myh7-Related Dilated Cardiomyopathy 22
Cardiomyopathy, Dilated, 1y 22
 
Cmd1 22


Classifications:



Summaries for Myh7-Related Dilated Cardiomyopathy

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MalaCards based summary: Myh7-Related Dilated Cardiomyopathy, also known as cardiomyopathy, dilated, 1y, is related to cardiomyopathy, dilated, 1e and scn5a-associated dilated cardiomyopathy. An important gene associated with Myh7-Related Dilated Cardiomyopathy is MYH7 (Myosin, Heavy Chain 7, Cardiac Muscle, Beta), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cardiac muscle contraction.

Related Diseases for Myh7-Related Dilated Cardiomyopathy

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Diseases in the Cardiomyopathy family:

Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1a
Cardiomyopathy, Dilated, 1v Cardiomyopathy, Dilated, 1d
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 1z Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1gg Cardiomyopathy, Dilated, 1l
Cardiomyopathy, Dilated, 1k Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1p Cardiomyopathy, Dilated, 1j
Cardiomyopathy, Dilated, 2b Cardiomyopathy, Dilated, 1q
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1t Cardiomyopathy, Dilated, 1ee
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1r
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff Cardiomyopathy, Dilated, 3b
Dilated Cardiomyopathy Lmna-Related Dilated Cardiomyopathy
Cardiomyopathy Due to Anthracyclines Familial Dilated Cardiomyopathy
Abcc9-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Actn2-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Csrp3-Related Dilated Cardiomyopathy
Des-Related Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Dsg2-Related Dilated Cardiomyopathy Eya4-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Gatad1-Related Dilated Cardiomyopathy
Lama4-Related Dilated Cardiomyopathy Ldb3-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
myh7-related dilated cardiomyopathy Nexn-Related Dilated Cardiomyopathy
Pln-Related Dilated Cardiomyopathy Psen1-Related Dilated Cardiomyopathy
Psen2-Related Dilated Cardiomyopathy Rbm20-Related Dilated Cardiomyopathy
Scn5a-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Taz-Related Dilated Cardiomyopathy Tcap-Related Dilated Cardiomyopathy
Tmpo-Related Dilated Cardiomyopathy Tnnc1-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Tnnt2-Related Dilated Cardiomyopathy
Tpm1-Related Dilated Cardiomyopathy Ttn-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy

Diseases related to Myh7-Related Dilated Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy, dilated, 1e30.6MYH7, SCN5A, TPM1
2scn5a-associated dilated cardiomyopathy10.3
3scn5a-related dilated cardiomyopathy10.3
4campomelic dysplasia10.2
5cardiomyopathy, dilated, 1a10.1
6tpm1-related dilated cardiomyopathy10.1
7rete ovarii adenoma9.9MYH7, TPM1
8cardiomyopathy, familial hypertrophic9.9MYH7, TPM1
9invasive bladder transitional cell carcinoma9.9MYH7, TPM1
10nephrogenic adenoma of urinary bladder9.8MYH7, SCN5A
11muscular dystrophy9.8MYH7, TPM1
12fat necrosis of breast9.8MYH7, TPM1
13congenital hemolytic anemia9.8MYH7, SCN5A
14myh7-related familial hypertrophic cardiomyopathy9.7MYH7, SCN5A, TPM1
15scn5a-related brugada syndrome9.7MYH7, SCN5A, TPM1
16scn5a-related romano ward syndrome9.7MYH7, SCN5A, TPM1
17sulfate transporter-related osteochondrodysplasia9.7MYH7, SCN5A, TPM1
18left-sided gallbladder9.7MYH7, SCN5A, TPM1
19septate vagina9.7MYH7, SCN5A, TPM1
20noonan syndrome 19.6MYH7, SCN5A, TPM1
21drug-induced hepatitis9.6MYH7, SCN5A, TPM1
22cardiomyopathy with or without skeletal myopathy9.6MYH7, SCN5A, TPM1

Graphical network of the top 20 diseases related to Myh7-Related Dilated Cardiomyopathy:



Diseases related to myh7-related dilated cardiomyopathy

Symptoms for Myh7-Related Dilated Cardiomyopathy

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Drugs & Therapeutics for Myh7-Related Dilated Cardiomyopathy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Myh7-Related Dilated Cardiomyopathy

Genetic Tests for Myh7-Related Dilated Cardiomyopathy

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Genetic tests related to Myh7-Related Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Myh7-Related Dilated Cardiomyopathy22 MYH7

Anatomical Context for Myh7-Related Dilated Cardiomyopathy

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Animal Models for Myh7-Related Dilated Cardiomyopathy or affiliated genes

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Publications for Myh7-Related Dilated Cardiomyopathy

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Variations for Myh7-Related Dilated Cardiomyopathy

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Clinvar genetic disease variations for Myh7-Related Dilated Cardiomyopathy:

5 (show all 15)
id Gene Variation Type Significance SNP ID Assembly Location
1TPM1NM_001018005.1(TPM1): c.160G> A (p.Glu54Lys)single nucleotide variantPathogenicrs104894505GRCh37Chr 15, 63336271: 63336271
2TPM1NM_001018005.1(TPM1): c.118G> A (p.Glu40Lys)single nucleotide variantPathogenicrs104894501GRCh37Chr 15, 63336229: 63336229
3MYH7NM_000257.3(MYH7): c.1573G> A (p.Glu525Lys)single nucleotide variantLikely pathogenic, Pathogenicrs606231324GRCh37Chr 14, 23897714: 23897714
4MYH7NM_000257.3(MYH7): c.5378_5380delTGC (p.Leu1793del)deletionPathogenicrs587779396GRCh37Chr 14, 23884383: 23884385
5MYH7NM_000257.3(MYH7): c.2710C> T (p.Arg904Cys)single nucleotide variantPathogenicrs727503253GRCh37Chr 14, 23893328: 23893328
6TPM1NM_001018005.1(TPM1): c.688G> A (p.Asp230Asn)single nucleotide variantPathogenicrs199476317GRCh37Chr 15, 63354462: 63354462
7SCN5ANM_198056.2(SCN5A): c.665G> A (p.Arg222Gln)single nucleotide variantLikely pathogenic, Pathogenicrs45546039GRCh37Chr 3, 38655272: 38655272
8MYH7NM_000257.3(MYH7): c.1106G> A (p.Arg369Gln)single nucleotide variantPathogenicrs397516089GRCh37Chr 14, 23899016: 23899016
9MYH7NM_000257.3(MYH7): c.3578G> A (p.Arg1193His)single nucleotide variantLikely pathogenic, Pathogenicrs397516187GRCh37Chr 14, 23889202: 23889202
10MYH7NM_000257.3(MYH7): c.5740G> A (p.Glu1914Lys)single nucleotide variantPathogenicrs397516254GRCh37Chr 14, 23883018: 23883018
11MYH7NM_000257.3(MYH7): c.602T> C (p.Ile201Thr)single nucleotide variantLikely pathogenic, Pathogenicrs397516258GRCh37Chr 14, 23901007: 23901007
12SCN5ANM_198056.2(SCN5A): c.1567C> T (p.Arg523Cys)single nucleotide variantLikely pathogenic, Pathogenicrs199473119GRCh37Chr 3, 38645526: 38645526
13SCN5ANM_198056.2(SCN5A): c.3823G> A (p.Asp1275Asn)single nucleotide variantPathogenicrs137854618GRCh37Chr 3, 38607917: 38607917
14SCN5ANM_000335.4(SCN5A): c.2549_2550dupTG (p.Phe851Cysfs)duplicationPathogenicrs397514450GRCh37Chr 3, 38627419: 38627420
15SCN5ANM_000335.4(SCN5A): c.4780G> C (p.Asp1594His)single nucleotide variantPathogenicrs137854607GRCh37Chr 3, 38595800: 38595800

Expression for genes affiliated with Myh7-Related Dilated Cardiomyopathy

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Search GEO for disease gene expression data for Myh7-Related Dilated Cardiomyopathy.

Pathways for genes affiliated with Myh7-Related Dilated Cardiomyopathy

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Pathways related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3MYH7, TPM1
29.3MYH7, TPM1
3
Show member pathways
8.5MYH7, SCN5A, TPM1

GO Terms for genes affiliated with Myh7-Related Dilated Cardiomyopathy

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Cellular components related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1stress fiberGO:00017259.5MYH7, TPM1
2sarcomereGO:00300179.3MYH7, TPM1
3Z discGO:00300189.0MYH7, SCN5A

Biological processes related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ventricular cardiac muscle tissue morphogenesisGO:00550109.4MYH7, TPM1
2muscle contractionGO:00069369.3MYH7, TPM1
3muscle filament slidingGO:00300499.0MYH7, TPM1
4regulation of heart rateGO:00020278.9MYH7, SCN5A
5cardiac muscle contractionGO:00600488.5MYH7, SCN5A, TPM1

Molecular functions related to Myh7-Related Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:00037799.3MYH7, TPM1
2calmodulin bindingGO:00055169.2MYH7, SCN5A

Sources for Myh7-Related Dilated Cardiomyopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet