MCID: MYH002
MIFTS: 15

Myh9-Related Disorders malady

Summaries for Myh9-Related Disorders

Sources:
19GeneReviews, 33MalaCards
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MalaCards: Myh9-Related Disorders is related to myh9 related thrombocytopenia and cataract. An important gene associated with Myh9-Related Disorders is MYH9 (myosin, heavy chain 9, non-muscle), and among its related pathways are Sweet Taste Signaling and Sertoli-Sertoli Cell Junction Dynamics. The compounds (+-)-blebbistatin and (r)-(+)-blebbistatin have been mentioned in the context of this disorder.

GeneReviews summary for myh9

Aliases & Classifications for Myh9-Related Disorders

Sources:
19GeneReviews
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Aliases & Descriptions:

myh9-related disorders 19


Related Diseases for Myh9-Related Disorders

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myh9-Related Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1myh9 related thrombocytopenia30.7MYH9
2cataract10.0MYH9
3myocarditis10.0MYH6

Clinical Features for Myh9-Related Disorders

Drugs & Therapeutics for Myh9-Related Disorders

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Myh9-Related Disorders

Drug clinical trials:

Search ClinicalTrials for Myh9-Related Disorders

Search NIH Clinical Center for Myh9-Related Disorders

Search CenterWatch for Myh9-Related Disorders

Genetic Tests for Myh9-Related Disorders

Anatomical Context for Myh9-Related Disorders

Animal Models for Myh9-Related Disorders or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Myh9-Related Disorders

Sources:
51PubMed
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Articles related to Myh9-Related Disorders:

idTitleAuthorsYear
1
MYH9-related disorders: report on a patient of Greek origin presenting with macroscopic hematuria and presenile cataract, caused by an R1165C mutation. (22627578)
2012
2
MYH9 related platelet disorders - often unknown and misdiagnosed. (21567368)
2011
3
Renal manifestations of patients with MYH9-related disorders. (21210153)
2011
4
CKD in MYH9-related disorders. (19726116)
2009
5
Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders. (19630815)
2009
6
MYH9-related platelet disorders. (19408192)
2009
7
Rod mutations associated with MYH9-related disorders disrupt nonmuscle myosin-IIA assembly. (15339844)
2005
8
Ultrastructural analysis of granulocyte inclusions in genetically confirmed MYH9-related disorders. (15020273)
2004
9
Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders. (11918549)
2002
10
MYH9-Related Disorders (20301740)
1993

Genetic Variations for Myh9-Related Disorders

Expression for genes affiliated with Myh9-Related Disorders

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myh9-Related Disorders

Search GEO for disease gene expression data for Myh9-Related Disorders.

Pathways for genes affiliated with Myh9-Related Disorders

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore
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Compounds for genes affiliated with Myh9-Related Disorders

Sources:
60Tocris Bioscience
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Compounds related to Myh9-Related Disorders according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1(+-)-blebbistatin609.1MYH9, MYH6
2(r)-(+)-blebbistatin609.1MYH9, MYH6
3(s)-(-)-blebbistatin609.0MYH9, MYH6
4bts608.8MYH9, MYH6

GO Terms for genes affiliated with Myh9-Related Disorders

Sources:
16Gene Ontology
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Cellular components related to Myh9-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stress fiberGO:0017259.1MYH9, MYH6

Biological processes related to Myh9-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1in utero embryonic developmentGO:0017019.1MYH9, MYH6
2ATP catabolic processGO:0062008.8MYH9, MYH6

Molecular functions related to Myh9-Related Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin-dependent ATPase activityGO:0308989.2MYH9, MYH6
2microfilament motor activityGO:0001469.1MYH9, MYH6
3actin bindingGO:0037799.1MYH9, MYH6
4ATPase activityGO:0168879.0MYH6, MYH9
5calmodulin bindingGO:0055168.8MYH9, MYH6

Products for genes affiliated with Myh9-Related Disorders

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myh9-Related Disorders

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet