MCID: MYC007
MIFTS: 82

Myocardial Infarction malady

Summaries for Myocardial Infarction

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Each year over a million people in the u.s. have a heart attack. about half of them die. many people have permanent heart damage or die because they don't get help immediately. it's important to know the symptoms of a heart attack and call 9-1-1 if someone is having them. those symptoms include chest discomfort - pressure, squeezing, or pain shortness of breath discomfort in the upper body - arms, shoulder, neck, back nausea, vomiting, dizziness, lightheadedness, sweating these symptoms can sometimes be different in women. what exactly is a heart attack? most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. often this leads to an irregular heartbeat - called an arrhythmia - that causes a severe decrease in the pumping function of the heart. a blockage that is not treated within a few hours causes the affected heart muscle to die. nih: national heart, lung, and blood institute

MalaCards: Myocardial Infarction, also known as myocardial infarctions, is related to acute myocardial infarction and coronary artery disease,. An important gene associated with Myocardial Infarction is MIAT (myocardial infarction associated transcript (non-protein coding)), and among its related pathways are Apoptosis Modulation and Signaling and Keap1-Nrf2 Pathway. The drugs acebutolol and atenolol and the compounds nitric oxide and lipid have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia:64 Myocardial infarction (from Latin: Infarctus myocardii, MI) or acute myocardial infarction (AMI) is the... more...

Description from OMIM:47 608446

Aliases & Classifications for Myocardial Infarction

Sources:
8Disease Ontology, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

myocardial infarction 8 47 10 45 31 61
myocardial infarctions 8 22
heart attack 8 34
mi - myocardial infarction 8
myocardial infarction nos 8
myocardial infarct 8
attack - heart 8


External Ids:

Disease Ontology8 DOID:5844
MeSH35 D009203
NCIt40 C27996

Related Diseases for Myocardial Infarction

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Myocardial Infarction family:

posterior myocardial infarction acute myocardial infarction
myocardial infarction, susceptibility to, 1 myocardial infarction 2

Diseases related to Myocardial Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 435)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction32.6CKM, OLR1, ACE
2coronary artery disease,31.5ACE, MEF2A, ITGB3, PPIG, GJA4, OLR1
3atherosclerosis31.2PPIG, PTGIS, ITGB3, PROCR, CIITA, GJA4
4coronary heart disease31.2PROCR, ITGB3, LTA, OLR1, ACE
5stroke, ischemic31.1PTGIS
6hypercholesterolemia30.8ACE, OLR1
7antiphospholipid syndrome30.8PROCR
8systemic lupus erythematosus30.8CIITA, PROCR, LTA, TNFSF4
9thromboembolism30.8PROCR
10insulin resistance30.7LTA, MEF2A, ACE
11vascular disease30.6OLR1, MEF2A, PTGIS, ACE, ITGB3
12kawasaki disease30.6CIITA
13thrombophilia30.6PROCR
14arthritis30.5GZMB, CASP1, LTA, CIITA
15asthma30.3CIITA, GZMB, ITGB3
16septic shock30.3LTA, CASP1, CIITA
17systemic scleroderma30.2ACE, CIITA, CASP1
18cadasil30.0MEF2A, LTA, CASP1, PPIG, ITGB3, CIITA
19alzheimer's disease30.0OLR1, MEF2A, CASP1, LRP8, PPIG
20adenocarcinoma30.0PPIG, GCLM, CASP1, PTGIS, ESR1
21graves' disease30.0CIITA, LTA
22colorectal cancer30.0GZMB, PPIG
23tuberculosis29.9CIITA, PPIG, GZMB
24inferior myocardial infarction11.3
25cardiogenic shock11.1
26cardiac rupture11.0
27posterior myocardial infarction11.0
28coronary thrombosis11.0
29silent myocardial infarction10.9
30angina pectoris10.9
31septal myocardial infarction10.9
32coronary aneurysm10.9
33myocardial infarction 210.9
34anteroseptal myocardial infarction10.8
35coronary artery aneurysm10.8
36myocardial infarction susceptibility10.8
37acute myocarditis10.7
38myocardial infarction, decreased10.7
39dextrocardia10.7
40lateral myocardial infarction10.7
41spontaneous coronary artery dissection10.7
42ventricular septal defect10.7
43apical myocardial infarction10.7
44atrioventricular block10.7
45subendocardial myocardial infarction10.6
46n syndrome10.6
47wolff-parkinson-white syndrome10.6
48anterolateral myocardial infarction10.6
49posterolateral myocardial infarction10.6
50hemopericardium10.6

Graphical network of the top 20 diseases related to Myocardial Infarction:



Diseases related to myocardial infarction

Clinical Features for Myocardial Infarction

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608446

Drugs & Therapeutics for Myocardial Infarction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myocardial Infarction

Drug clinical trials:

Search ClinicalTrials for Myocardial Infarction

Search NIH Clinical Center for Myocardial Infarction

Search CenterWatch for Myocardial Infarction

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Myocardial Infarction cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Myocardial Infarction:
ADRCs, adipose-derived regenerative cells for treatment of cardiovascular disease
AMI MultiStem
AMR-001, bone marrow-derived CD34+ cells for myocardial infarction
Autologous bone marrow-derived mononuclear cells for myocardial infarction
Bone marrow or peripheral blood-derived stem cells for treatment of myocardial ischemia
Bone marrow-derived adult mononuclear cells for heart diseases
Bone marrow-derived CD133+ vs. mononuclear cells for treatment of myocardial infarction
Bone marrow-derived mesenchymal stem cells for treatment of myocardial ischemia
Bone marrow-derived mononuclear cells for acute myocardial infarction
Bone marrow-derived mononuclear cells for myocardial infarction
Bone marrow-derived mononuclear cells for myocardial infarction
Bone marrow-derived mononuclear cells for myocardial infarction
Bone marrow-derived mononuclear cells for treatment of myocardial infarction
Bone marrow-derived progenitor cells for myocardial infarction
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Cardiosphere-derived autologous stem cells for reverse ventricular dysfunction
Cardiosphere-derived cells for the treatment of myocardial infarction
CD133+ bone marrow-derived stem cells in conjuction with coronary artery bypass grafting
Combination therapy of mononuclear cells with laser for coronary disease
Early endothelial progenitor cells for acute myocardial infarction
Embryonic stem cell-derived cardiomyocyte transplantation for myocardial infarction
Embryonic stem cell-derived cardiomyocytes for treatment of myocardial infarction
Enriched bone marrow-derived progenitor cells for heart diseases
Hearticellgram
Hydrogels with cardiomyocytes for myocardial repair
Mesenchymal precursor cells for cardiovascular diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
MyoCell
Prochymal
Sca-1-positive cardiac progenitor cells for treatment of myocardial infarction
Stem cell therapy for treatment of acute myocardial infarction
StempeucelAMI
Umbilical cord blood-derived CD133 positive cells for treatment of myocardial infarction
Embryonic/Adult Cultured Cells Related to Myocardial Infarction:
Adipose-derived stem and regenerative cell, PMIDs: 21082397, 22281257
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 22004910, 22052917
Bone marrow-derived autologous CD34+cells (AMR-001), PMID: 21167340
Bone marrow-derived mononuclear cells, PMID: 19002124
Bone marrow-derived mononuclear cells
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells, PMIDs: 22137069, 19699857, 20445812, 20524773
Bone marrow-derived CD133+ hematopoietic stem cells
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells, PMID: 22834565
Bone marrow-derived mononuclear cells, PMID: 22834565
Bone marrow-derived mononuclear cells (family), PMIDs: 22192151, 21414223
Bone marrow-derived mononuclear cells (family), PMIDs: 16889856, 16382259
Bone marrow-derived mesenchymal stem cells, PMIDs: 16889856, 16382259
Bone marrow-derived mononuclear cells
Bone marrow-derived progenitor cells, PMIDs: 20448133, 16159812, 18293890
Bone marrow-derived mesenchymal stem cells , PMIDs: 21392602, 22940024
Bone marrow-derived mononuclear cells (family), PMIDs: 21392602, 22940024
Porcine bone marrow-derived mesenchymal stem cells, PMIDs: 21392602, 22940024
Cardiosphere-derived cells, PMID: 22336189
Cardiosphere-derived cells, PMIDs: 17283259, 22336189
Bone marrow-derived CD133+ cells, PMID: 17320570
Bone marrow-derived mononuclear cells (family)
eNOS-transfected endothelial progenitor cells, PMIDs: 21362705, 22239631
Peripheral blood-derived endothelial progenitor cells, PMIDs: 21362705, 22239631
Cardiomyocyte-like cells, PMID: 17980256
Cardiomyocyte-like cells, PMID: 22040108
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived mesenchymal stem cells (family)
Neonatal rat ventricular cardiomyocytes , PMID: 21783246
Cardiomyocyte-like cells, PMID: 21783246
Mesenchymal Precursor Cells (STRO-3 selected), PMIDs: 20850099, 21155976
Bone marrow-derived mononuclear cells, PMIDs: 21323410, 20631864
Bone marrow-derived mesenchymal stem cells, PMIDs: 21323410, 20631864
Skeletal myoblasts (MyoCell, PMIDs: 19051139, 15615560, 16446778
Cardiac progenitor cells (Sca1+), PMID: 21980409
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived CD34+/CXCR4+ cells
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444
Umbilical cord blood-derived CD133+ cells, PMID: 16195418

Genetic Tests for Myocardial Infarction

Sources:
22GTR
See all sources

Genetic tests related to Myocardial Infarction:

id Genetic test Affiliating Genes
1 Myocardial Infarction22

Anatomical Context for Myocardial Infarction

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Myocardial Infarction:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
3 HeartMyocardiumCardiomyocytes Potential therapeutic candidate, affected by disease

Animal Models for Myocardial Infarction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myocardial Infarction

Sources:
51PubMed
See all sources

Articles related to Myocardial Infarction:

(show top 50)    (show all 6095)
idTitleAuthorsYear
1
Preventive angioplasty in myocardial infarction. (24428479)
2014
2
Comparison between drug-eluting and bare metal stent on ST-elevation myocardial infarction outcome: Should second-generation drug-eluting stent be preferred? (24365386)
2013
3
Clinical outcomes of everolimus- and zotarolimus-eluting stents in patients with acute myocardial infarction for small coronary artery disease. (24314902)
2013
4
Association of gender, tumor necrosis factor inhibitor therapy, and myocardial infarction risk in patients with psoriasis. (24034374)
2013
5
Impairment of vascular endothelial function following reperfusion therapy in patients with acute myocardial infarction. (23771713)
2013
6
Impact of cardiac magnet resonance imaging on management of ventricular septal rupture after acute myocardial infarction. (23710303)
2013
7
Outcomes following percutaneous coronary intervention and coronary artery bypass grafting surgery in Chinese, South Asian and White patients with acute myocardial infarction: administrative data analysis. (24369071)
2013
8
Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. (22513132)
2012
9
Incidental finding of cor triatriatum sinister in an adult post-myocardial infarction. (21257322)
2011
10
Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial. (21093861)
2011
11
Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study. (21672190)
2011
12
Cardiac rupture in acute myocardial infarction: post-mortem MR imaging. (22214911)
2011
13
Cost effectiveness of eplerenone in patients with heart failure after acute myocardial infarction who were taking both ACE inhibitors and beta-blockers: subanalysis of the EPHESUS. (20104935)
2010
14
Synergistic activity of Fagonia arabica and Heteropneustes fossilis extracts against myocardial, cerebral infarction, and embolism disorder in mice. (21814440)
2010
15
Association of the insulin-like growth factor1 gene with myocardial infarction in Japanese subjects. (21039458)
2010
16
Analysis of polymorphism of three positions of promoter region of TNF- gene in patients with ischemic heart disease, unstable angina and myocardial infarction]. (20146672)
2010
17
Expression of genes connected with nuclear factor kappa B (NFkappaB) estimated by oligonucleotide microarray analysis HG-U133A in patients with acute myocardial infarction]. (19928652)
2009
18
B-type natriuretic peptide as predictor of heart failure in patients with acute ST elevation myocardial infarction, single-vessel disease, and complete revascularization: follow-up study. (19839068)
2009
19
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (18178577)
2008
20
Cardiac troponin I vs EuroSCORE: myocardial infarction and hospital mortality. (18381864)
2008
21
Thunderclap headache as the presenting symptom of myocardial infarction. (17501856)
2007
22
Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction. (16939410)
2007
23
The effect of glycoprotein IIIa A1/A2 gene polymorphism on one-year outcome in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. (17206538)
2006
24
Right bundle branch block during the acute phase of myocardial infarction: modern redefinitions of old concepts. (16269420)
2006
25
Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction. (16611201)
2006
26
Plasminogen activator inhibitor-1 4G/5G polymorphism and efficacy of reperfusion therapy in acute myocardial infarction. (16175011)
2005
27
Up-regulated synthesis of mature-type adrenomedullin in coronary circulation immediately after reperfusion in patients with anterior acute myocardial infarction. (15927712)
2005
28
Early initiation of statin therapy in patients with acute myocardial infarction after successful percutaneous coronary intervention]. (15532243)
2004
29
Hepatocyte growth factor production may be related to the inflammatory response in patients with acute myocardial infarction. (11922273)
2002
30
A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats. (11399246)
2001
31
Beta-blockers, angiotensin-converting enzyme inhibitors, and calcium antagonists in treatment of elderly patients with acute myocardial infarction. (10860176)
2000
32
Homocyst(e)ine and the C677T mutation of methylenetetrahydrofolate reductase in survivors of premature myocardial infarction. (11074245)
2000
33
Vascular and haemostatic gene polymorphisms associated with non-fatal myocardial infarction: a critical review. (10806985)
2000
34
Tobacco smoking modifies association between Gln-Arg192 polymorphism of human paraoxonase gene and risk of myocardial infarction. (10978258)
2000
35
Age-related serum levels of insulin-like growth factor-I, -II and IGF-binding protein-3 following myocardial infarction. (10931745)
2000
36
Argatroban and alteplase in patients with acute myocardial infarction: the ARGAMI Study. (11122543)
2000
37
Associations of fibrinogen, factor VII and PAI-1 with baseline findings among 10,500 male participants in a prospective study of myocardial infarction--the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction. (9843166)
1998
38
Acute myocardial infarction associated with hypereosinophilic syndrome in a young man. (9293413)
1997
39
Patient preferences for thrombolytic therapy in acute myocardial infarction. (9343805)
1997
40
Thrombolytic and antithrombotic treatment in myocardial infarction: main achievements and future perspectives. (7591320)
1995
41
The peak of creatine phosphokinase level in the acute phase of myocardial infarction in patients with and without ischemic precedents]. (7609890)
1995
42
Prehospital-initiated vs hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Intervention Trial. (8355383)
1993
43
Analytical and clinical evaluation of creatine kinase MB mass assay by IMx: comparison with MB isoenzyme activity and serum myoglobin for early diagnosis of myocardial infarction. (1458571)
1992
44
Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction. (1279272)
1992
45
Effects of smoking on HDL subfractions in myocardial infarction patients: effects on lecithin-cholesterol acyltransferase and hepatic lipase. (2029776)
1991
46
Influence of angiotensin-converting enzyme inhibition on cardiac function in myocardial infarction. (2181851)
1990
47
Silent myocardial infarction complicated by asymptomatic ventricular septal defect and deferred rupture of left ventricular pseudoaneurysm. (15227401)
1990
48
Coronary artery aneurysm and myocardial infarction resulting in sudden death of a 6 year-old child: a case report. (6113758)
1980
49
Cardiac rupture after myocardial infarction. (727135)
1978
50
Correlation of electrocardiographic and vectorcardiographic findings in diagnosis of infero-posterior myocardial infarction. (5559190)
1971

Genetic Variations for Myocardial Infarction

Expression for genes affiliated with Myocardial Infarction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myocardial Infarction

Search GEO for disease gene expression data for Myocardial Infarction.

Pathways for genes affiliated with Myocardial Infarction

Sources:
38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Myocardial Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0LTA, GZMB, CASP1
210.8GCLM, GCLC
310.8GCLM, GCLC

Compounds for genes affiliated with Myocardial Infarction

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Myocardial Infarction according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1nitric oxide45 11 2414.8LTA, CKM, GCLM, CASP1, GZMB, PROCR
2lipid4512.7PROCR, LTA, OLR1, LRP8, ACE, PTGIS
3calcium45 50 11 2415.2CIITA, GZMB, CASP1, ITGB3, CKM, PROCR
4serine4512.1CKM, CASP1, CIITA, GZMB, MEF2A, PROCR
5steroid4512.0ESR1, LTA, CIITA, ITGB3, MEF2A, PPIG
6cysteine4511.9GCLC, CKM, OLR1, CIITA, ITGB3, GZMB
7oxygen45 2412.8PTGIS, OLR1, GCLC, CIITA, CKM, CASP1
8cyclosporin a45 29 6013.8CASP1, PPIG, LTA, CIITA, MEF2A, GZMB
9cholesterol45 29 11 2414.8PTGIS, ACE, LRP8, OLR1, LTA, CIITA
10vegf4511.7LTA, CASP1, GZMB, ITGB3, PROCR, ESR1
11retinoic acid45 2412.5CASP1, LTA, GJA4, GZMB, MEF2A, ESR1
12cisplatin45 50 60 1114.5CASP1, GCLC, GCLM, GZMB, PPIG
13glucose4511.5GZMB, CKM, MEF2A, OLR1
14endotoxin4511.4CASP1, CIITA, PROCR, LTA
15aspirin45 50 29 2414.3PTGIS, CASP1, ITGB3, ACE
16z-dqmd-fmk60 2912.3CASP1, PPIG, GZMB
17az 104178086011.3CASP1, GZMB, PPIG
18z-devd-fmk60 2912.3PPIG, CASP1, GZMB
19dexamethasone45 50 29 1114.3LTA, PPIG, GZMB, CASP1, CIITA
20z-vad-fmk45 6012.3GZMB, PPIG, CASP1
21clopidogrel50 45 11 2414.3PPIG, ACE, ITGB3
22pravastatin45 50 29 11 2415.1CASP1, PPIG, OLR1
234-hydroxynonenal45 2412.1GCLC, CASP1, GCLM
24diethylmaleate4511.0GCLM, GCLC
25actinomycin d4510.8CIITA, CASP1, LTA, ESR1
26sele4510.8ITGB3, ACE
27toxin-14510.7LTA, CIITA

GO Terms for genes affiliated with Myocardial Infarction

Sources:
16Gene Ontology
See all sources

Cellular components related to Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate-cysteine ligase complexGO:01710910.8GCLM, GCLC

Biological processes related to Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of mitochondrial depolarizationGO:05190010.9GCLM, GCLC
2response to nitrosative stressGO:05140910.9GCLM, GCLC
3cysteine metabolic processGO:00653410.8GCLM, GCLC
4glutathione biosynthetic processGO:00675010.8GCLM, GCLC
5glutamate metabolic processGO:00653610.7GCLC, GCLM
6regulation of blood vessel sizeGO:05088010.5GCLM, GCLC

Molecular functions related to Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.2CASP1, GZMB, PPIG, MEF2A, ITGB3, CIITA
2activating transcription factor bindingGO:03361310.8CIITA, MEF2A
3glutamate-cysteine ligase activityGO:00435710.7GCLM, GCLC

Products for genes affiliated with Myocardial Infarction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myocardial Infarction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet