Myocardial Infarction Susceptibility malady

MalaCards: Myocardial Infarction Susceptibility, also known as myocardial infarction, is related to acute myocardial infarction and atherosclerosis. An important gene associated with Myocardial Infarction Susceptibility is MCI2 (Myocardial infarction, susceptiblity to, 2). The drugs timolol and verapamil and the compounds diethylmaleate and hyaluronic acid have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and liver/biliary system.

myocardial infarction susceptibility 33 myocardial infarction 43

Diseases related to myocardial infarction susceptibility by text searches and GeneDecks gene sharing:

(show top 50)    (show all 253)

id	Related Disease	Score	Top Affiliating Genes
1	acute myocardial infarction	39.3	MMP2, APOB, APOE, OLR1, LTA, ACE
2	atherosclerosis	35.6	ESR1, TNFSF4
3	blindness	32.2	APOB, APOE, ESR1, ACE, THBD
4	thrombophilia	31.2	APOB, APOE, ACE, THBD
5	ischemic heart disease	30.8	APOB, OLR1, ACE
6	thrombosis	30.8	MMP2, APOB, APOE, ESR1, OLR1, LTA
7	hyperhomocysteinemia	30.5	APOB, APOE, ACE, THBD
8	ischemia	30.3	MMP2, APOB, APOE, ESR1, AIF1, OLR1
9	cholesterol	30.3	LRP8, MMP2, APOB, APOE, ESR1, TNFSF4
10	homocysteine	30.2	MMP2, APOB, APOE, ESR1, LTA, ACE
11	hypertension	30.2	LRP8, GCLC, MMP2, APOB, APOE, ESR1
12	type 2 diabetes mellitus	30.0	APOB, APOE, ACE, THBD
13	coronary heart disease	29.9	LGALS2, MMP2, APOB, APOE, ESR1, TNFSF4
14	coronary stenosis	29.7	APOB, APOE, OLR1, ACE
15	diabetes mellitus	29.7	GCLC, MMP2, APOB, APOE, ESR1, OLR1
16	antiphospholipid syndrome	29.3	LRP8, MMP2, APOB, THBD
17	atrial fibrillation	29.2	MMP2, APOE, ESR1, ACE, THBD
18	obesity, association with	29.1	APOB, ESR1, ACE
19	hypercholesterolemia	29.0	APOB, APOE, ESR1, OLR1, ACE, THBD
20	familial hypercholesterolemia	28.9	APOB, APOE, ESR1, ACE, THBD
21	insulin resistance	28.9	APOB, APOE, ESR1, OLR1, LTA, ACE
22	cerebrovascular disease	28.6	APOB, APOE, OLR1, LTA, ACE, THBD
23	sinusitis	28.5	MMP2, LTA, ACE, THBD
24	obesity	28.4	MMP2, APOB, APOE, ESR1, AIF1, OLR1
25	alzheimer's disease	28.4	APOE, ACE
26	hemolytic anemia	28.3	GCLC, GCLM, THBD
27	asthma	28.2	GCLC, GCLM, AIF1, LTA
28	diabetic retinopathy	28.0	MMP2, APOE, LTA, ACE, THBD
29	myocardial infarction	27.7	LRP8, GCLC, GCLM, LGALS2, MIAT, ESR1
30	periodontitis	27.3	MMP2, APOE, ESR1, LTA, ACE, THBD
31	dementia	26.9	LRP8, MMP2, APOB, APOE, ESR1, ACE
32	hypothyroidism	26.9	APOB, APOE, LTA, ACE, THBD
33	nephrotic syndrome	26.9	APOB, APOE, LTA, ACE, THBD
34	arteriosclerosis	26.7	MMP2, APOB, APOE, ACE
35	cerebrovascular accident	26.7	APOB, APOE, AIF1, ACE, THBD
36	cadasil	26.5	APOB, APOE, OLR1, LTA, ACE, THBD
37	hepatitis	26.4	LRP8, GCLC, MMP2, APOB, APOE, ESR1
38	essential hypertension	26.2	MMP2, APOB, APOE, TNFSF4, OLR1, LTA
39	systemic lupus erythematosus	26.0	MMP2, APOB, APOE, ESR1, AIF1, TNFSF4
40	lupus erythematosus	26.0	MMP2, APOB, APOE, ESR1, AIF1, TNFSF4
41	fibrosis	25.7	GCLC, MMP2, APOB, APOE, ESR1, AIF1
42	rheumatoid arthritis	25.2	LGALS2, MMP2, APOB, APOE, ESR1, AIF1
43	arthritis	25.2	LGALS2, MMP2, APOB, APOE, ESR1, AIF1
44	multiple sclerosis	24.9	MMP2, APOB, APOE, ESR1, LTA, ACE
45	cerebral infarction	24.8	LGALS2, APOB, APOE, ESR1, AIF1, TNFSF4
46	nephropathy	24.2	GCLM, MMP2, APOB, APOE, ESR1, OLR1
47	cerebritis	23.9	LRP8, LGALS2, MMP2, APOB, APOE, ESR1
48	neuronitis	23.4	LRP8, GCLC, GCLM, MMP2, MIAT, APOE
49	eisenmenger syndrome	13.1	ACE, THBD
50	cerebral atherosclerosis	13.0	APOE, ACE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acebutolol, acebutolol hydrochloride, alteplase,recombinant, anisindione, anistreplase, atenolol, bisoprolol, bisoprolol fumarate, carvedilol, carvedilol phosphate, dalteparin, dalteparin sodium, enoxaparin, eptifibatide, esmolol, esmolol hydrochloride, heparin, heparin calcium, heparin sodium, heparin sodium (beef lung), heparin sodium (beef), heparin sodium (pork), labetalol, labetalol hydrochloride, lidocaine hydrochloride, metoprolol, metoprolol succinate, metoprolol tartrate, nadolol, nitroglycerin, penbutolol, penbutolol sulfate, pindolol, propranolol, propranolol hydrochloride, reteplase,recombinant, streptokinase, sulfinpyrazone, tenecteplase, timolol, timolol hemihydrate, timolol maleate, tirofiban, tirofiban hydrochloride, urokinase, verapamil, verapamil hydrochloride

MGI Mouse Phenotypes related to myocardial infarction susceptibility:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	10.2	OLR1
2	liver/biliary system phenotype	MP:0005370	9.6	APOB, GCLC
3	growth/size phenotype	MP:0005378	7.3	LRP8, THBD, ACE, LTA, APOE, APOB
4	cellular phenotype	MP:0005384	7.2	LRP8, GCLC, GCLM, APOE, ESR1, TNFSF4
5	cardiovascular system phenotype	MP:0005385	6.5	MMP2, THBD, ACE, LTA, OLR1, TNFSF4
6	homeostasis/metabolism phenotype	MP:0005376	6.2	THBD, ACE, LTA, OLR1, TNFSF4, ESR1
7	mortality/aging	MP:0010768	5.9	ACE, LTA, ESR1, APOE, LRP8, GCLC

Articles related to myocardial infarction susceptibility:

id	Title	Authors	Year	Affiliating Genes
1	Association of matrix metalloproteinase-2 gene promot er polymorphism with myocardial infarction susceptibility in a Mexican populati on. (19700865)	Delgado-Enciso I.... Ortiz-Lopez R.	2009	MMP2
2	Identification of 46 novel SNPs in the 130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21. (12920609)	Iida A.... Nakamura Y.	2003	AIF1

Genes related to myocardial infarction susceptibility according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	MCI2	Myocardial infarction, susceptiblity to, 2	11.0
2	MIAT	myocardial infarction associated transcript (non-protein coding)	11.0
3	LGALS2	lectin, galactoside-binding, soluble, 2	11.0
4	TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	11.0
5	GCLM	glutamate-cysteine ligase, modifier subunit	11.0
6	OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	11.0
7	LRP8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	11.0
8	GCLC	glutamate-cysteine ligase, catalytic subunit	11.0
9	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0
10	THBD	thrombomodulin	11.0
11	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0
12	ESR1	estrogen receptor 1	11.0
13	AIF1	allograft inflammatory factor 1	11.0	Publications
14	APOB	apolipoprotein B (including Ag(x) antigen)	11.0
15	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
16	APOE	apolipoprotein E	11.0

Compounds related to myocardial infarction susceptibility according to GeneDecks:

(show all 45)

id	Compound	Score	Top Affiliating Genes
1	diethylmaleate32	10.2	GCLM, GCLC
2	hyaluronic acid32 18	11.2	LTA, THBD
3	sitosterol32	9.7	APOE, APOB
4	campesterol32 18	10.7	APOB, APOE
5	ascorbic acid32 18	10.6	MMP2, OLR1
6	desogestrel32 9 9	11.6	APOB, ESR1
7	sele32	9.6	ACE, APOE
8	lercanidipine32 9 9	11.6	ACE, MMP2
9	isradipine32 9 42 9	12.6	ACE, APOB
10	cholestyramine32	9.5	APOB, APOE
11	lathosterol32 18	10.5	APOB, APOE
12	kininogen32	9.4	ACE, THBD, APOB
13	pdtc32	9.4	MMP2, GCLC, GCLM
14	fluvastatin32 34 9 9	12.3	THBD, APOE, APOB
15	losartan32 34 9 9	12.3	THBD, ACE, APOE, OLR1
16	pentoxifylline32 9 9	11.3	LTA, MMP2, THBD
17	xbai32	9.3	APOB, APOE, ESR1
18	betacarotene32	9.3	THBD, APOE, APOB
19	retinyl palmitate32 18	10.2	APOE, APOB
20	4-hydroxynonenal32 18	10.2	GCLC, GCLM, APOB, APOE
21	simvastatin32 34 42 9 18 9	14.1	APOB, OLR1, THBD, APOE
22	pioglitazone32 9 9	11.1	MMP2, APOB, OLR1
23	vitamin d32	9.0	LTA, THBD, APOE, ESR1
24	thyroxine32 18	10.0	APOB, APOE, THBD, LTA
25	captopril32 42 9 9	12.0	ACE, MMP2, APOB
26	warfarin32 34 9 18 9	13.0	THBD, APOB, APOE, ACE
27	homocysteine32 18	10.0	THBD, APOB, APOE
28	nitric oxide32 9 18 9	11.9	THBD, ACE, LTA, GCLM, OLR1, LRP8
29	phospholipid32	8.8	THBD, LRP8, OLR1, APOE, APOB
30	prednisolone32 9 9	10.7	MMP2, APOB, LTA, THBD
31	lovastatin32 42 9 9	11.7	APOB, APOE, MMP2
32	folate32	8.5	MMP2, THBD, APOE, APOB
33	rosiglitazone32 9 18 9	11.5	APOE, APOB, MMP2
34	actinomycin d32	8.5	ESR1, THBD, APOE, LTA
35	paraffin32	8.4	LTA, APOE, MMP2, ESR1, THBD
36	pravastatin32 34 9 18 9	12.3	MMP2, APOB, APOE, OLR1, THBD
37	atorvastatin32 34 9 18 9	12.3	MMP2, THBD, OLR1, APOE, APOB
38	aspirin32 34 18	10.2	MMP2, APOB, APOE, ACE, THBD
39	creatinine32	8.1	APOB, APOE, ACE, THBD, MMP2
40	cholesterol32 9 18 9	11.1	THBD, ACE, LTA, OLR1, APOE, LRP8
41	h2o232	8.0	LTA, APOE, MMP2, APOB, THBD
42	lipid32	8.0	LRP8, APOE, APOB, THBD, ACE, LTA
43	cycloheximide32	7.8	MMP2, APOE, THBD, LTA, ESR1, APOB
44	vegf32	7.7	APOE, ESR1, LTA, THBD, APOB, MMP2
45	estrogen32	7.6	APOB, LTA, APOE, MMP2, THBD, ESR1

Cellular components related to myocardial infarction susceptibility according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	low-density lipoprotein particle	GO:034362	9.3	APOB, APOE
2	intermediate-density lipoprotein particle	GO:034363	9.2	APOB, APOE
3	chylomicron	GO:042627	9.0	APOB, APOE
4	extracellular space	GO:005615	7.1	MMP2, THBD, ACE, LTA, TNFSF4, APOE

Biological processes related to myocardial infarction susceptibility according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cysteine metabolic process	GO:006534	10.1	GCLC, GCLM
2	regulation of blood vessel size	GO:050880	10.0	GCLC, GCLM
3	glutamate metabolic process	GO:006536	10.0	GCLM, GCLC
4	glutathione biosynthetic process	GO:006750	9.8	GCLM, GCLC
5	negative regulation of platelet activation	GO:010544	9.8	THBD, APOE
6	negative regulation of blood coagulation	GO:030195	9.6	THBD, APOE
7	positive regulation of nitric-oxide synthase activity	GO:051000	9.6	APOE, ESR1
8	lipoprotein metabolic process	GO:042157	9.3	APOB, APOE, OLR1
9	cholesterol metabolic process	GO:008203	9.3	APOE, APOB, TNFSF4
10	response to lipopolysaccharide	GO:032496	9.1	THBD, LTA, APOB
11	leukocyte migration	GO:050900	8.9	THBD, APOB, OLR1

Molecular functions related to myocardial infarction susceptibility according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate-cysteine ligase activity	GO:004357	9.6	GCLC, GCLM
2	low-density lipoprotein particle receptor binding	GO:050750	9.3	APOB, APOE