MCID: MYC005
MIFTS: 49

Myocardial Stunning malady

Summaries for Myocardial Stunning

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63Wikipedia, 32MalaCards
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Wikipedia:63 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

MalaCards: Myocardial Stunning is related to ischemia and myocardial infarction. An important gene associated with Myocardial Stunning is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and Folate Metabolism. The compounds tetrahydrobiopterin and losartan have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Aliases & Classifications for Myocardial Stunning

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

myocardial stunning 8 10 44 60


External Ids:

Disease Ontology8 DOID:9767
MeSH34 D017682

Related Diseases for Myocardial Stunning

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17GeneCards, 18GeneDecks
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Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.1KCNJ5, CAT, SOD1, TNNT2, OPRD1, EDN1
2myocardial infarction31.1SLC9A3R2, PTGS2, SERPINC1, SLC9A1, SIX4, KCNJ5
3acute myocardial infarction30.7KCNJ5, CAT, SOD3, TNNT2, TNNI3, EDN1
4coronary artery disease30.6KCNJ5, SOD3, EDN1, AGTR2, AGTR1, AHSP
5hypertrophic cardiomyopathy30.5TNNI3, TNNT2
6hypertension30.1AGTR1, EDN1
7colon cancer30.1PTGS2, NOS2
8coronary stenosis10.4
9image syndrome10.3
10pulmonary edema10.1
11cerebritis10.1
12cervicitis10.1
13hyperthyroidism10.1
14kidney disease10.1
15peritonitis10.1
16alpha thalassemia10.0AHSP
17cystic fibrosis10.0SLC9A3R2
18malignant glioma10.0SLC9A1
19pneumonia10.0SOD3
20deficiency anemia10.0AHSP
21pheochromocytoma10.0AGTR2
22eclampsia10.0SERPINC1
23ureteral obstruction10.0AGTR1
24dementia10.0AGTR1
25purpura10.0SERPINC1
26nephrotic syndrome10.0SERPINC1
27obesity10.0SLC9A1, KCNJ5
28pulmonary embolism10.0SERPINC1
29thromboembolism10.0SERPINC1
30acute pancreatitis10.0SOD1
31bronchopulmonary dysplasia10.0SOD1
32mitral valve prolapse10.0AGTR1
33amyotrophic lateral sclerosis10.0SOD1
34pancreatitis10.0SOD1
35ovarian cancer10.0AGTR1
36hypoglycemia10.0OPRD1, KCNJ5
37hellp syndrome10.0SERPINC1
38hepatitis10.0CAT
39brain edema10.0SOD1
40infertility10.0CAT
41disseminated intravascular coagulation10.0SERPINC1
42leukemia10.0CAT
43astrocytoma10.0NOS2
44hypermethioninemia10.0SOD1
45stroke, ischemic10.0EDN1
46down syndrome10.0KCNJ5, SOD1
47glaucoma10.0EDN1
48renovascular hypertension10.0AHSP, AGTR1
49portal hypertension10.0EDN1
50vesicoureteral reflux10.0AGTR1, AGTR2

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to myocardial stunning

Clinical Features for Myocardial Stunning

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Drugs & Therapeutics for Myocardial Stunning

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Myocardial Stunning

Search CenterWatch for Myocardial Stunning

Genetic Tests for Myocardial Stunning

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Anatomical Context for Myocardial Stunning

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32MalaCards
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MalaCards organs/tissues related to Myocardial Stunning:

32
Heart, Endothelial, Brain, Colon, Kidney, Testes

Animal Models for Myocardial Stunning or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myocardial Stunning:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0SIX5, AGTR2
2MP:00053909.3SOD3, AGTR2, SIX4
3MP:00053678.7AGTR2, AGTR1, NOS2, PTGS2, SERPINC1, EDN1
4MP:00053697.5SOD1, TNNT2, TNNI3, EDN1, AGTR2, SIX5
5MP:00053857.3KCNJ5, SOD1, TNNT2, TNNI3, EDN1, AGTR2
6MP:00036317.1SOD1, OPRD1, EDN1, AGTR2, SIX4, SLC9A1
7MP:00053766.2SERPINC1, CAT, SOD3, SOD1, TNNT2, OPRD1
8MP:00107686.2EDN1, TNNI3, TNNT2, SOD1, SOD3, CAT

Publications for Myocardial Stunning

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50PubMed
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Articles related to Myocardial Stunning:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Non-invasive ventilation for severe TRALI and myocardial stunning: report and literature review. (22869453)
2012
2
Distinct effects of acute pretreatment with lipophilic and hydrophilic statins on myocardial stunning, arrhythmias and lethal injury in the rat heart subjected to ischemia/reperfusion. (22106818)
2011
3
Myocardial stunning after electroconvulsive therapy in patients with an apparently normal heart. (19225404)
2009
4
Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. (18094670)
2008
5
Diastolic Ca2+ overload caused by Na+/Ca2+ exchanger during the first minutes of reperfusion results in continued myocardial stunning. (17822695)
2007
6
Importance of gated imaging in both phases of myocardial perfusion SPECT: myocardial stunning after dipyridamole infusion. (16751586)
2006
7
Heart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament. (16470090)
2006
8
Utility of levosimendan, a new calcium sensitizing agent, in the treatment of cardiogenic shock due to myocardial stunning in patients with ST-elevation myocardial infarction: a series of cases. (15901754)
2005
9
Protease inhibitor leupeptin attenuates myocardial stunning in rat heart. (14704627)
2004
10
Xenon improves recovery from myocardial stunning in chronically instrumented dogs. (15333388)
2004
11
Myocardial stunning: an experimental act with a large clinical audience. (12868349)
2003
12
Increases in myocardial cyclic GMP attenuate contractile delay in myocardial stunning. (12269791)
2002
13
Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don>t. (11991727)
2002
14
Myocardial stunning reduces the effects of nitric oxide on coronary capillary perfusion in the rabbit. (12089601)
2002
15
TY-12533, a novel Na(+)/H(+) exchange inhibitor, prevents myocardial stunning in dogs. (11348635)
2001
16
Isoflurane-induced protection against myocardial stunning is independent of adenosine 1 (A(1)) receptor in isolated rat heart. (11493499)
2001
17
Hemin, inducer of heme-oxygenase 1, improves functional recovery from myocardial stunning in conscious dogs. (11505343)
2001
18
The novel glycolipid RC-552 attenuates myocardial stunning and reduces infarct size in dogs. (10860773)
2000
19
Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts. (11033115)
2000
20
Lack of nuclear apoptosis in cardiomyocytes and increased endothelin-1 levels in a rat heart model of myocardial stunning. (11005586)
2000
21
Reduction in the level of cardiac cyclic GMP worsens contractile delay in myocardial stunning. (10864491)
2000
22
Myocardial stunning caused by sympathetic nerve injury after an operation on cervical vertebrae. (10201624)
1999
23
Mild myocardial stunning affects platelet aggregation and certain hemostatic factors in swine. (10726020)
1999
24
Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning. (10484406)
1999
25
Ischemic threshold and myocardial stunning in the aging heart. (10622422)
1999
26
Is myocardial stunning of clinical importance? A surgeon's perspective. (9689441)
1998
27
Thoracic epidural anesthesia does not affect functional recovery from myocardial stunning in sevoflurane-anesthetized dogs. (9854664)
1998
28
Mitochondrial response to heart rate steps in isolated rabbit heart is slowed after myocardial stunning. (9201029)
1997
29
Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. (9168782)
1997
30
Myocardial stunning, hibernation, and ischemic preconditioning. (8910163)
1996
31
Nisoldipine attenuates myocardial stunning induced by multiple coronary occlusions in conscious pigs and this effect is independent of changes in hemodynamics or coronary blood flow. (8732494)
1996
32
Effects of a new endothelin receptor antagonist, TAK-044, on myocardial stunning in dogs. (8813544)
1996
33
Pharmacological evidence for persistent activation of ATP-sensitive potassium channels in the early phase of reperfusion and its protective role against myocardial stunning. (8901700)
1996
34
Diagnosis of myocardial stunning: a new use for myocardial contrast and dobutamine echocardiography. (8680143)
1995
35
Acute plaque rupture and myocardial stunning in patient with normal coronary arteriography. (7603266)
1995
36
Increased plasma levels of interleukin-6 and myocardial stunning after coronary reperfusion therapy. (7572634)
1995
37
Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs. (7814639)
1995
38
Ubiquity of myocardial stunning. (8534239)
1995
39
Norepinephrine, enoximone, and nitric oxide for treatment of myocardial stunning and pulmonary hypertension in a newborn with diaphragmatic hernia. (7666310)
1995
40
Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects. (8396504)
1993
41
Cellular and subcellular aspects of myocardial stunning. (8461518)
1993
42
Effect of transforming growth factor-beta 1 on myocardial stunning in the intact dog. (8340931)
1993
43
Protective effect of the protease inhibitor leupeptin against myocardial stunning. (7690085)
1993
44
Complete prevention of myocardial stunning, contracture, low-reflow, and edema after heart transplantation by blocking neutrophil adhesion molecules during reperfusion. (1360556)
1992
45
Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. (1301066)
1992
46
Myocardial stunning: a role for calcium antagonists during reperfusion? (1516108)
1992
47
Focused issue on myocardial stunning. (1756131)
1991
48
Effect of global myocardial stunning on Ca2(+)-sensitive myofibrillar ATPase activity and creatine kinase kinetics. (2144402)
1990
49
Myocardial stunning in dogs: preconditioning effect and influence of coronary collateral flow. (2200251)
1990
50
Sensitization of reperfused myocardium to subsequent coronary flow reductions. An extension of the concept of myocardial stunning. (3409506)
1988

Genetic Variations for Myocardial Stunning

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Expression for genes affiliated with Myocardial Stunning

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for genes affiliated with Myocardial Stunning

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49PharmGKB, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Myocardial Stunning

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Myocardial Stunning according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1tetrahydrobiopterin44 11 2412.3PTGS2, AHSP
2losartan44 49 28 1113.1EDN1
3alpha-phenyl-n-tert-butylnitrone4410.1SOD3, CAT, SOD1
4s-nitrosocysteine4410.1NOS2, AHSP, SOD1
5pyrogallol4410.0SOD1, SOD3, CAT
6isosorbide dinitrate44 49 1112.0AHSP, KCNJ5, EDN1
71,3-dimethyl-2-thiourea449.9CAT, EDN1, SOD1
8thiobarbituric acid449.9SOD1, SOD3, CAT
9trimetazidine449.9CAT, SOD1, EDN1
10ptio449.9NOS2, CAT, SOD1
11superoxide44 2410.8AHSP, AGTR1, OPRD1, SOD3, KCNJ5
12nadph44 2410.8AHSP, SOD3, SLC9A1, AGTR2
13prostaglandin449.8KCNJ5, AGTR2, AGTR1, AHSP
14captopril44 28 49 59 1113.8EDN1, AGTR2, AGTR1, AHSP
15nitrate449.7SOD3, EDN1, NOS2, KCNJ5
16glutamate449.7AGTR2, AGTR1, AHSP, OPRD1, KCNJ5
17ng-nitro-l-arginine449.7EDN1, AHSP, SOD1, NOS2
18xanthine44 2410.7AGTR2, CAT, SOD3, SOD1
198-isoprostane449.7SOD1, CAT, AGTR1, EDN1
20ang ii449.7AGTR2, EDN1, NOS2, AGTR1
21apocynin44 5910.6EDN1, NOS2, SOD1, CAT
22norepinephrine44 11 2411.6SLC9A1, AHSP, OPRD1, KCNJ5, AGTR2
23n(g)-nitro-l-arginine methyl ester449.6KCNJ5, SOD1, EDN1, NOS2, AHSP
24oxygen44 2410.5OPRD1, KCNJ5, SOD3, AGTR2, AHSP, NOS2
25silymarin449.5CAT, SOD1, NOS2, PTGS2
26phenylephrine44 28 11 2412.5NOS2, EDN1, AGTR1, AHSP
27cariporide449.5EDN1, SLC9A3R2, SLC9A1
28peroxynitrite449.5NOS2, SOD1, SOD3, CAT
29acetylcholine44 49 28 11 2413.5AHSP, AGTR1, OPRD1, SOD3, KCNJ5, NOS2
30s-nitroso-n-acetylpenicillamine449.5CAT, SOD1, EDN1, NOS2, AHSP
31cgmp44 2810.4AHSP, KCNJ5, EDN1, AGTR2, NOS2, AGTR1
32isoproterenol44 1110.4EDN1, AGTR1, AHSP, NOS2, OPRD1
33nitroglycerin44 1110.3KCNJ5, SOD1, AGTR1, AHSP, NOS2, EDN1
34thromboxane a244 2410.3PTGS2, AHSP, AGTR1, EDN1
35ebselen449.3CAT, SOD1, NOS2
36pdtc449.3NOS2, PTGS2, SOD1, CAT
37l-nmma449.2AGTR1, EDN1, SOD1, CAT, AHSP, NOS2
38potassium44 11 2411.2SLC9A1, AHSP, AGTR1, KCNJ5, TNNI3, OPRD1
39n acetylcysteine448.9SOD3, SOD1, NOS2, PTGS2, SERPINC1, AGTR1
40creatinine448.9TNNT2, TNNI3, SERPINC1, AGTR1, AGTR2, EDN1
41sodium nitroprusside448.8AHSP, KCNJ5, CAT, SOD3, SOD1, NOS2
42indomethacin44 59 28 1111.7EDN1, SOD1, CAT, KCNJ5, AGTR2, NOS2
43prostacyclin448.7SOD1, SERPINC1, PTGS2, NOS2, AHSP, AGTR1
44arginine448.5AHSP, NOS2, SERPINC1, SOD3, SOD1, OPRD1
45lactate448.5TNNI3, TNNT2, SOD1, SLC9A1, CAT, KCNJ5
46sodium44 249.5EDN1, OPRD1, KCNJ5, AGTR1, AGTR2, AHSP
47alanine448.5SOD3, SOD1, SERPINC1, SLC9A1, AGTR1, AGTR2
48lipid448.1SOD3, SOD1, CAT, KCNJ5, OPRD1, AGTR1
49nitric oxide44 11 249.5KCNJ5, CAT, PTGS2, NOS2, SLC9A3R2, AHSP
50calcium44 49 11 2410.4AHSP, KCNJ5, TNNT2, TNNI3, SLC9A1, OPRD1

GO Terms for genes affiliated with Myocardial Stunning

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16Gene Ontology
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Cellular components related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.6NOS2, SOD1, CAT
2troponin complexGO:0058619.6TNNI3, TNNT2

Biological processes related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR2, AGTR1
2hemoglobin metabolic processGO:02002710.2AHSP, CAT
3heart contractionGO:06004710.2SOD1, TNNI3
4removal of superoxide radicalsGO:01943010.2SOD1, SOD3
5response to copper ionGO:04668810.1SOD1, SOD3
6negative regulation of ATPase activityGO:03278010.1TNNI3, TNNT2
7elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.9AGTR1, EDN1
8regulation of blood pressureGO:0082179.8PTGS2, AGTR2, SOD1
9positive regulation of nitric oxide biosynthetic processGO:0454299.8EDN1, AGTR2, PTGS2
10positive regulation of smooth muscle contractionGO:0459879.8EDN1, PTGS2
11prostaglandin biosynthetic processGO:0015169.8EDN1, PTGS2
12superoxide anion generationGO:0425549.7SOD1, EDN1
13regulation of sensory perception of painGO:0519309.7SLC9A1, EDN1, OPRD1
14positive regulation of renal sodium excretionGO:0358159.6EDN1, AGTR2
15response to hypoxiaGO:0016669.6NOS2, EDN1, SOD3, CAT
16G-protein coupled receptor signaling pathwayGO:0071869.5OPRD1, EDN1, AGTR2, AGTR1

Molecular functions related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.0AGTR1, AGTR2
2troponin C bindingGO:0301729.8TNNT2, TNNI3
3superoxide dismutase activityGO:0047849.7SOD1, SOD3
4protein bindingGO:0055156.2SERPINC1, KCNJ5, SOD3, SOD1, TNNI3, OPRD1

Products for genes affiliated with Myocardial Stunning

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Sources for Myocardial Stunning

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet