MCID: MYC005
MIFTS: 51

Myocardial Stunning malady

Cardiovascular diseases category

Summaries for Myocardial Stunning

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66Wikipedia, 34MalaCards
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Wikipedia:66 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

MalaCards: Myocardial Stunning is related to ischemia and myocardial infarction. An important gene associated with Myocardial Stunning is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds alpha-phenyl-n-tert-butylnitrone and pyrogallol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are renal/urinary system and skeleton.

Aliases & Classifications for Myocardial Stunning

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

myocardial stunning 9 11 46 63


External Ids:

Disease Ontology9 DOID:9767
MeSH36 D017682

Related Diseases for Myocardial Stunning

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18GeneCards, 19GeneDecks
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Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.8EDN1, KCNJ5, AHSP, TNNT2, SOD1, CAT
2myocardial infarction30.6AGTR1, AGTR2, SLC9A3R2, SLC9A1, SOD3, SERPINC1
3coronary artery disease30.6TNNI3, SERPINC1, TNNT2, AGTR1, AHSP, EDN1
4acute myocardial infarction30.4SLC9A1, AGTR1, SOD3, CAT, SERPINC1, EDN1
5hypertension30.3EDN1, AGTR1
6endotheliitis10.5
7artery disease10.4
8hypertrophic cardiomyopathy10.4
9aneurysm10.3
10hypoxia10.3
11blindness10.3
12cardiogenic shock10.3
13pulmonary edema10.1
14cerebritis10.1
15cervicitis10.1
16colon cancer10.1
17coronary stenosis10.1
18hyperthyroidism10.1
19kidney disease10.1
20peritonitis10.1
21spontaneous coronary artery dissection10.1
22stress cardiomyopathy10.1
23morphine dependence10.1OPRD1
24hypermethioninemia10.1SOD1
25coronary thrombosis10.1SERPINC1
26diabetic cataract10.1CAT
27renovascular hypertension10.1AHSP, AGTR1
28hyperaldosteronism10.1AGTR1, KCNJ5
29low renin hypertension10.1EDN1
30conn's syndrome10.1AGTR2, AGTR1
31familial restrictive cardiomyopathy10.1TNNT2, TNNI3
32eclampsia10.1SERPINC1
33congestive heart failure10.1TNNI3, TNNT2
34sudden cardiac death multi-gene panels10.1KCNJ5, TNNI3, TNNT2
35vesicoureteral reflux10.1AGTR2, AGTR1
36coronary artery vasospasm10.1AHSP, EDN1
37familial hypertrophic cardiomyopathy10.1TNNI3, TNNT2
38raynaud disease10.1EDN1, AGTR1
39esophagitis10.0SLC9A1, CAT
40pneumoconiosis10.0CAT, SOD1
41cor pulmonale10.0EDN1, AGTR1
42intermediate coronary syndrome10.0SERPINC1, TNNT2, TNNI3
43senile cataract10.0CAT, SOD1
44hyperhomocysteinemia10.0SOD1, SERPINC1, SOD3
45portal hypertension10.0EDN1, AGTR1
46diabetic angiopathy10.0CAT, EDN1
47cerebrovascular disease10.0AGTR1, AGTR2, SERPINC1, KCNJ5
48peyronie's disease10.0NOS2, SOD1
49hyperinsulinism10.0AGTR1, KCNJ5, EDN1
50arteriosclerosis10.0SOD1, AHSP, EDN1

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to myocardial stunning

Symptoms for Myocardial Stunning

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Drugs & Therapeutics for Myocardial Stunning

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Myocardial Stunning

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Anatomical Context for Myocardial Stunning

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34MalaCards
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MalaCards organs/tissues related to Myocardial Stunning:

34
Heart, Endothelial, Brain, Colon, Kidney, Testes

Animal Models for Myocardial Stunning or affiliated genes

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38MGI
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Publications for Myocardial Stunning

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53PubMed
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Articles related to Myocardial Stunning:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction: a meta-analysis of prospective trials. (23575990)
2013
2
High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine. (23806450)
2013
3
Non-invasive ventilation for severe TRALI and myocardial stunning: report and literature review. (22869453)
2012
4
Nitric oxide has no obligatory role in isoflurane late preconditioning against myocardial stunning. (23044225)
2012
5
Complex I syndrome in myocardial stunning and the effect of adenosine. (21723387)
2011
6
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine. (20464430)
2010
7
Myocardial stunning after electroconvulsive therapy in patients with an apparently normal heart. (19225404)
2009
8
Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. (17719165)
2008
9
Ca2+ sensitizer superior to catecholamine during myocardial stunning? (18539040)
2008
10
Re: Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. (18506208)
2008
11
Myocardial stunning due to sudden emotional stress. (15877319)
2005
12
Effects of endogenous adenosine and adenosine receptor agonists on hypoxia-induced myocardial stunning in Guinea-pig atria and papillary muscles. (15076219)
2004
13
Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning. (15031126)
2004
14
Ischemic shortening of action potential duration as a result of KATP channel opening attenuates myocardial stunning by reducing calcium influx. (12190121)
2002
15
Increases in myocardial cyclic GMP attenuate contractile delay in myocardial stunning. (12269791)
2002
16
Clinical manifestations of myocardial stunning. (11491200)
2001
17
Myocardial stunning in exercise-induced ischemia in dogs: lack of late preconditioning. (11123245)
2001
18
Nitric oxide donors attenuate myocardial stunning in conscious rabbits. (10600874)
1999
19
In search of the proteins that cause myocardial stunning. (10473676)
1999
20
Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning. (10533603)
1999
21
Gated single-photon emission tomography imaging protocol to evaluate myocardial stunning after exercise. (10638404)
1999
22
Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway. (10600873)
1999
23
Aminoguanidine inhibits inducible NOS and reverses cardiac dysfunction late after ischemia and reperfusion--implications for iNOS-mediated myocardial stunning. (10443512)
1999
24
Effects of azelnidipine, a dihydropyridine calcium antagonist, on myocardial stunning in dogs. (9623715)
1998
25
17-Beta estradiol regulation of myocardial glutathione and its role in protection against myocardial stunning in dogs. (9733360)
1998
26
Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning. (9559621)
1998
27
Adenosine attenuates in vivo myocardial stunning with minimal effects on cardiac energetics. (9782373)
1998
28
Myocardial stunning--ups and downs in the Dolomites. (9689434)
1998
29
Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism. (9670920)
1998
30
Randomized, double-blind crossover study to investigate the effects of amlodipine and isosorbide mononitrate on the time course and severity of exercise-induced myocardial stunning. (9727544)
1998
31
Prospective identification of myocardial stunning using technetium-99m sestamibi-based measurements of infarct size. (9385887)
1997
32
Activation of adenosine receptors before ischemia enhances tolerance against myocardial stunning in the rabbit heart. (8522700)
1996
33
Effect of trimetazidine on postischemic regional myocardial stunning in the halothane-anesthetized dog. (8891873)
1996
34
Do ATP-sensitive potassium channels play a role in myocardial stunning? (8534242)
1995
35
The effects of modulation of the L-arginine-nitric oxide pathway on myocardial stunning following repetitive coronary occlusion in dogs. (8857235)
1995
36
Commentary on myocardial stunning and its clinical relevance. (8534253)
1995
37
Myocardial stunning following respiratory arrest. (7587461)
1995
38
Diagnosis of myocardial stunning: a new use for myocardial contrast and dobutamine echocardiography. (8680143)
1995
39
Acute plaque rupture and myocardial stunning in patient with normal coronary arteriography. (7603266)
1995
40
Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide. (8087948)
1994
41
Inhibition of glycolysis or increased perfusate H+ buffering capacity, but not their combination, attenuates myocardial stunning. (8287444)
1993
42
Myocardial stunning and preconditioning: age, species, and model related differences: role of AMP-5'-nucleotidase in myocardial injury and protection. (8461514)
1993
43
Transient left ventricular dyskinesia as a consequence of myocardial stunning. (1442512)
1992
44
Prominent negative T waves with QT prolongation indicate reperfusion injury and myocardial stunning. (1339791)
1992
45
Myocardial stunning following coronary angioplasty: protective effects of calcium-channel blockers. (1282609)
1992
46
Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. (1423931)
1992
47
Cellular mechanisms of myocardial stunning. (1562175)
1992
48
Effects of an increase in intracellular free [Mg2+] after myocardial stunning on sarcoplasmic reticulum Ca2+ transport. (1884459)
1991
49
Effect of global myocardial stunning on Ca2(+)-sensitive myofibrillar ATPase activity and creatine kinase kinetics. (2144402)
1990
50
Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts. (3417873)
1988

Variations for Myocardial Stunning

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Expression for genes affiliated with Myocardial Stunning

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for genes affiliated with Myocardial Stunning

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Sources:
51PathCards, 52PharmGKB, 31KEGG, 39NCBI BioSystems Database, 13EMD Millipore, 56Reactome, 61Thomson Reuters, 55R&D Systems
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Pathways related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9AGTR2, AGTR1
2
Show member pathways
Peptide GPCRs39
9.7AGTR2, OPRD1, AGTR1
3
Show member pathways
Vitamin B12 Metabolism39
9.5SOD3, SOD1, CAT
49.5CAT, SOD3, SOD1
59.5CAT, SOD3, SOD1
6
Show member pathways
9.5CAT, SOD1, SOD3
79.5NOS2, PTGS2
89.3SLC9A1, TNNI3, TNNT2
9
Show member pathways
9.3SOD1, CAT, NOS2
109.3NOS2, CAT, SOD1
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1NOS2, EDN1, PTGS2
12
Show member pathways
thioredoxin pathway39
9.0CAT, SOD1, PTGS2, SOD3
138.9NOS2, SLC9A1, PTGS2
148.8SLC9A1, AGTR1, AGTR2, TNNI3, TNNT2

Compounds for genes affiliated with Myocardial Stunning

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Myocardial Stunning according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1alpha-phenyl-n-tert-butylnitrone469.9CAT, SOD1, SOD3
2pyrogallol469.9SOD3, CAT, SOD1
3s-nitrosocysteine469.8NOS2, SOD1, AHSP
41,3-dimethyl-2-thiourea469.7EDN1, SOD1, CAT
5trimetazidine469.7EDN1, SOD1, CAT
6isosorbide dinitrate46 52 1211.7EDN1, KCNJ5, AHSP
7thiobarbituric acid469.7SOD3, SOD1, CAT
8captopril46 62 52 30 1213.6EDN1, AHSP, AGTR2, AGTR1
9diphenyliodonium469.6SOD1, CAT, NOS2
10ptio469.6NOS2, CAT, SOD1
11nitrate469.5EDN1, KCNJ5, NOS2, SOD3
12xanthine46 2510.5AGTR2, SOD3, SOD1, CAT
13ng-nitro-l-arginine469.4NOS2, SOD1, AHSP, EDN1
148-isoprostane469.4CAT, SOD1, EDN1, AGTR1
15ang ii469.4AGTR2, EDN1, NOS2, AGTR1
16n(g)-nitro-l-arginine methyl ester469.3NOS2, SOD1, AHSP, KCNJ5, EDN1
17apocynin46 6210.3SOD1, CAT, NOS2, EDN1
18prostaglandin469.2AGTR1, AGTR2, PTGS2, AHSP, KCNJ5
19phenylephrine46 30 25 1212.1EDN1, NOS2, AGTR1, AHSP
20s-nitroso-n-acetylpenicillamine469.1AHSP, NOS2, CAT, SOD1, EDN1
21silymarin469.1SOD1, CAT, NOS2, PTGS2
22cgmp46 3010.1AGTR1, NOS2, AHSP, KCNJ5, AGTR2, EDN1
23isoproterenol46 1210.0EDN1, OPRD1, NOS2, AGTR1, AHSP
24tetrahydrobiopterin46 25 1211.0PTGS2, SOD1, CAT, AHSP, NOS2
25nitroglycerin46 1210.0SOD1, KCNJ5, AGTR1, NOS2, EDN1, AHSP
26peroxynitrite469.0SOD3, SOD1, CAT, NOS2
27potassium46 25 1210.9KCNJ5, TNNI3, OPRD1, SLC9A1, AGTR1, AHSP
28cariporide468.9SLC9A1, EDN1, SLC9A3R2
29l-nmma468.8AHSP, EDN1, NOS2, SOD1, CAT, AGTR1
30pdtc468.8PTGS2, SOD1, CAT, NOS2
31acetylcholine46 52 30 25 1212.8OPRD1, AHSP, AGTR1, NOS2, SOD3, EDN1
32creatinine468.7TNNT2, SOD1, SERPINC1, AGTR2, TNNI3, EDN1
33norepinephrine46 25 1210.6OPRD1, AGTR1, AGTR2, SLC9A1, EDN1, KCNJ5
34heparin46 30 25 1211.5OPRD1, SOD3, SERPINC1, AHSP, TNNT2, AGTR1
35lactate468.5TNNT2, KCNJ5, SOD1, SLC9A1, CAT, TNNI3
36egcg468.5CAT, PTGS2, SOD1, SLC9A1, NOS2
37sodium nitroprusside468.4AHSP, KCNJ5, EDN1, SOD3, SOD1, CAT
38n acetylcysteine468.3AGTR1, NOS2, SOD1, SOD3, PTGS2, CAT
39alanine468.2AGTR1, AGTR2, TNNT2, SLC9A1, SERPINC1, SOD3
40glutamate468.2OPRD1, KCNJ5, AHSP, SOD1, AGTR1, AGTR2
41indomethacin46 30 62 1211.1AGTR2, KCNJ5, AHSP, PTGS2, SOD1, NOS2
42nadph46 259.1NOS2, AHSP, SOD3, SOD1, CAT, SLC9A1
43prostacyclin468.1SOD1, AGTR2, AGTR1, SERPINC1, PTGS2, AHSP
44arginine468.1AGTR2, EDN1, SOD3, AGTR1, NOS2, OPRD1
45sodium46 258.8SLC9A1, OPRD1, KCNJ5, EDN1, AGTR2, AHSP
46superoxide46 258.7OPRD1, CAT, SOD3, SOD1, AHSP, AGTR1
47lipid467.5AGTR1, SOD1, KCNJ5, AHSP, CAT, SOD3
48calcium46 52 25 129.8SLC9A1, AGTR2, AGTR1, EDN1, KCNJ5, AHSP
49oxygen46 257.7AGTR1, SLC9A1, NOS2, OPRD1, CAT, SOD1
50nitric oxide46 25 128.5EDN1, SOD1, AGTR1, AGTR2, SLC9A3R2, NOS2

GO Terms for genes affiliated with Myocardial Stunning

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17Gene Ontology
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Cellular components related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.6TNNT2, TNNI3
2peroxisomeGO:0057779.3SOD1, CAT, NOS2
3plasma membraneGO:0058866.9KCNJ5, SERPINC1, SOD1, CAT, OPRD1, SLC9A1

Biological processes related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1angiotensin-activated signaling pathwayGO:03816610.3AGTR2, AGTR1
2renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR2, AGTR1
3negative regulation of ATPase activityGO:03278010.2TNNT2, TNNI3
4hemoglobin metabolic processGO:02002710.2CAT, AHSP
5heart contractionGO:06004710.2TNNI3, SOD1
6removal of superoxide radicalsGO:01943010.2SOD1, SOD3
7response to copper ionGO:04668810.1SOD1, SOD3
8positive regulation of renal sodium excretionGO:03581510.0EDN1, AGTR2
9positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.0EDN1, AGTR1
10superoxide anion generationGO:0425549.9EDN1, SOD1
11ventricular cardiac muscle tissue morphogenesisGO:0550109.9TNNI3, TNNT2
12regulation of vasoconstrictionGO:0192299.9EDN1, AGTR1
13nitric oxide mediated signal transductionGO:0072639.9NOS2, AGTR2
14prostaglandin biosynthetic processGO:0015169.7EDN1, PTGS2
15regulation of blood pressureGO:0082179.7AGTR2, SOD1, PTGS2
16positive regulation of smooth muscle contractionGO:0459879.7EDN1, PTGS2
17superoxide metabolic processGO:0068019.7SOD1, NOS2
18positive regulation of nitric oxide biosynthetic processGO:0454299.7AGTR2, PTGS2, EDN1
19G-protein coupled receptor signaling pathwayGO:0071869.6AGTR1, AGTR2, OPRD1, EDN1
20regulation of sensory perception of painGO:0519309.5SLC9A1, OPRD1, EDN1
21positive regulation of vasodilationGO:0459099.5AGTR2, NOS2
22regulation of pHGO:0068859.3SLC9A1, EDN1
23response to hypoxiaGO:0016669.3EDN1, SOD3, CAT, NOS2

Molecular functions related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.9TNNI3, TNNT2
2angiotensin type II receptor activityGO:0049459.8AGTR2, AGTR1
3superoxide dismutase activityGO:0047849.6SOD3, SOD1
4heme bindingGO:0200379.1NOS2, CAT, PTGS2
5protein bindingGO:0055156.1AGTR1, EDN1, KCNJ5, TNNI3, SERPINC1, SOD3

Products for genes affiliated with Myocardial Stunning

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Sources for Myocardial Stunning

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet