MCID: MYC005
MIFTS: 49

Myocardial Stunning malady

Summaries for Myocardial Stunning

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63Wikipedia, 32MalaCards
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Wikipedia:63 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

MalaCards: Myocardial Stunning is related to ischemia and myocardial infarction. An important gene associated with Myocardial Stunning is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and Folate Metabolism. The compounds tetrahydrobiopterin and losartan have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Aliases & Classifications for Myocardial Stunning

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

myocardial stunning 8 10 44 60


External Ids:

Disease Ontology8 DOID:9767
MeSH34 D017682

Related Diseases for Myocardial Stunning

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17GeneCards, 18GeneDecks
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Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.1KCNJ5, CAT, SOD1, TNNT2, OPRD1, EDN1
2myocardial infarction31.1SLC9A3R2, PTGS2, SERPINC1, SLC9A1, SIX4, KCNJ5
3acute myocardial infarction30.7KCNJ5, CAT, SOD3, TNNT2, TNNI3, EDN1
4coronary artery disease30.6KCNJ5, SOD3, EDN1, AGTR2, AGTR1, AHSP
5hypertrophic cardiomyopathy30.5TNNI3, TNNT2
6hypertension30.1AGTR1, EDN1
7colon cancer30.1PTGS2, NOS2
8coronary stenosis10.4
9image syndrome10.3
10pulmonary edema10.1
11cerebritis10.1
12cervicitis10.1
13hyperthyroidism10.1
14kidney disease10.1
15peritonitis10.1
16alpha thalassemia10.0AHSP
17cystic fibrosis10.0SLC9A3R2
18malignant glioma10.0SLC9A1
19pneumonia10.0SOD3
20deficiency anemia10.0AHSP
21pheochromocytoma10.0AGTR2
22eclampsia10.0SERPINC1
23ureteral obstruction10.0AGTR1
24dementia10.0AGTR1
25purpura10.0SERPINC1
26nephrotic syndrome10.0SERPINC1
27obesity10.0SLC9A1, KCNJ5
28pulmonary embolism10.0SERPINC1
29thromboembolism10.0SERPINC1
30acute pancreatitis10.0SOD1
31bronchopulmonary dysplasia10.0SOD1
32mitral valve prolapse10.0AGTR1
33amyotrophic lateral sclerosis10.0SOD1
34pancreatitis10.0SOD1
35ovarian cancer10.0AGTR1
36hypoglycemia10.0OPRD1, KCNJ5
37hellp syndrome10.0SERPINC1
38hepatitis10.0CAT
39brain edema10.0SOD1
40infertility10.0CAT
41disseminated intravascular coagulation10.0SERPINC1
42leukemia10.0CAT
43astrocytoma10.0NOS2
44hypermethioninemia10.0SOD1
45stroke, ischemic10.0EDN1
46down syndrome10.0KCNJ5, SOD1
47glaucoma10.0EDN1
48renovascular hypertension10.0AHSP, AGTR1
49portal hypertension10.0EDN1
50vesicoureteral reflux10.0AGTR1, AGTR2

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to myocardial stunning

Clinical Features for Myocardial Stunning

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Drugs & Therapeutics for Myocardial Stunning

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myocardial Stunning

Drug clinical trials:

Search ClinicalTrials for Myocardial Stunning

Search NIH Clinical Center for Myocardial Stunning

Search CenterWatch for Myocardial Stunning

Genetic Tests for Myocardial Stunning

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Anatomical Context for Myocardial Stunning

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32MalaCards
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MalaCards organs/tissues related to Myocardial Stunning:

32
Heart, Endothelial, Brain, Colon, Kidney, Testes

Animal Models for Myocardial Stunning or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myocardial Stunning:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0SIX5, AGTR2
2MP:00053909.3SOD3, AGTR2, SIX4
3MP:00053678.7AGTR2, AGTR1, NOS2, PTGS2, SERPINC1, EDN1
4MP:00053697.5SOD1, TNNT2, TNNI3, EDN1, AGTR2, SIX5
5MP:00053857.3KCNJ5, SOD1, TNNT2, TNNI3, EDN1, AGTR2
6MP:00036317.1SOD1, OPRD1, EDN1, AGTR2, SIX4, SLC9A1
7MP:00053766.2SERPINC1, CAT, SOD3, SOD1, TNNT2, OPRD1
8MP:00107686.2EDN1, TNNI3, TNNT2, SOD1, SOD3, CAT

Publications for Myocardial Stunning

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50PubMed
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Articles related to Myocardial Stunning:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction: a meta-analysis of prospective trials. (23575990)
2013
2
Isoflurane late preconditioning against myocardial stunning is associated with enhanced antioxidant defenses. (22103751)
2012
3
Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. (22263852)
2012
4
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine. (20464430)
2010
5
Myocardial stunning in hemodialysis: what is the overall message? (20955278)
2010
6
Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. (19559670)
2009
7
Determinants of delayed preconditioning against myocardial stunning in chronically-instrumented pigs. (20160844)
2009
8
Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen. (19203898)
2009
9
Myocardial stunning after successful defibrillation. (17698278)
2008
10
The inotropic adaptation during late preconditioning against myocardial stunning is associated with an increase in FKBP12.6. (17188666)
2007
11
Conversion of post-systolic wall thickening into ejectional thickening by selective heart rate reduction during myocardial stunning. (17376788)
2007
12
Overestimation of postischemic myocardial stunning on gated SPECT imaging: correlation with echocardiography. (16919575)
2006
13
Levosimendan: a promising treatment for myocardial stunning? (16409345)
2006
14
Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning. (12531734)
2003
15
Upregulation of angiotensin II type 2 receptor and limitation of myocardial stunning by angiotensin II type 1 receptor blockers during reperfused myocardial infarction in the rat. (14506547)
2003
16
Ischemic shortening of action potential duration as a result of KATP channel opening attenuates myocardial stunning by reducing calcium influx. (12190121)
2002
17
Absence of exacerbation of myocardial stunning in anesthetized dogs treated with KAD-1229, a novel hypoglycemic agent. (11730726)
2001
18
Myocardial stunning after streptokinase: what is the significance of the Q wave? (10814645)
2000
19
Noninvasive assessment of myocardial stunning from short-term coronary occlusion using tagged magnetic resonance imaging. (11545128)
2000
20
Effect of uridine derivatives on myocardial stunning during postischemic reperfusion of rat heart. (11177294)
2000
21
Lipophilic HMG-CoA reductase inhibitors increase myocardial stunning in dogs. (10672858)
2000
22
Effect of pre-reperfusion residual flow on recovery from myocardial stunning: a myocardial contrast echocardiography study. (10625827)
2000
23
A mouse model of myocardial stunning. (10904251)
2000
24
Deletion of endothelial nitric oxide synthase exacerbates myocardial stunning in an isolated mouse heart model. (10945953)
2000
25
Molecular and cellular mechanisms of myocardial stunning. (10221990)
1999
26
Adenosine attenuates in vivo myocardial stunning with minimal effects on cardiac energetics. (9782373)
1998
27
Class I antiarrhythmic drugs alter the severity of myocardial stunning by modulating ATP-sensitive K+ channels in guinea pig ventricular muscles. (9550300)
1998
28
Adenosine receptor blockade enhances myocardial stunning without a sustained effect on fluorine-18-FDG uptake postreperfusion. (9627323)
1998
29
Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbits. (9760299)
1998
30
Posttransplant primary heart dysfunction and myocardial stunning. (9412890)
1997
31
Myocardial stunning: do we know the mechanism? (9457363)
1997
32
The early and late phases of ischemic preconditioning: a comparative analysis of their effects on infarct size, myocardial stunning, and arrhythmias in conscious pigs undergoing a 40-minute coronary occlusion. (9130454)
1997
33
Activation of adenosine receptors before ischemia enhances tolerance against myocardial stunning in the rabbit heart. (8522700)
1996
34
Enhancement of postischemic myocardial stunning by calcium overload in hearts of diabetic rats. (8614283)
1996
35
Attenuation of myocardial stunning in isolated rat hearts by a 21-aminosteroid lazaroid (U74389G). (8945679)
1996
36
Myocardial stunning and hibernation. (9062030)
1996
37
The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview. (8660262)
1996
38
Protective effect of nifedipine on myocardial stunning in isolated rabbit hearts: role of high energy phosphates stores. (8793016)
1996
39
The effects of modulation of the L-arginine-nitric oxide pathway on myocardial stunning following repetitive coronary occlusion in dogs. (8857235)
1995
40
Endogenous adenosine attenuates myocardial stunning by antiadrenergic effects exerted during ischemia and not during reperfusion. (7769809)
1995
41
Inhibition of sarcoplasmic reticulum calcium release reduces myocardial stunning. (8361166)
1993
42
Myocardial stunning after coronary bypass surgery. (8461512)
1993
43
Potential role of neutrophil anti-adhesion therapy in myocardial stunning, myocardial infarction, and organ dysfunction after cardiopulmonary bypass. (8461523)
1993
44
Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning. (8394226)
1993
45
The relationship between ischemia-reperfusion injury, myocardial stunning and cardiac preconditioning. (8322165)
1993
46
Metabolic correlates of myocardial stunning and the effect of cardiopulmonary bypass. (8461515)
1993
47
Influences of pravastatin and simvastatin, HMG-CoA reductase inhibitors, on myocardial stunning in dogs. (7509904)
1993
48
Mitochondrial function in myocardial stunning. (2038066)
1991
49
Myocardial stunning. (1671946)
1991
50
Effects of transient coronary occlusion: experience with myocardial stunning and preconditioning. (2807863)
1989

Genetic Variations for Myocardial Stunning

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Expression for genes affiliated with Myocardial Stunning

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for genes affiliated with Myocardial Stunning

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49PharmGKB, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Myocardial Stunning

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Myocardial Stunning according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1tetrahydrobiopterin44 11 2412.3PTGS2, AHSP
2losartan44 49 28 1113.1EDN1
3alpha-phenyl-n-tert-butylnitrone4410.1SOD3, CAT, SOD1
4s-nitrosocysteine4410.1NOS2, AHSP, SOD1
5pyrogallol4410.0SOD1, SOD3, CAT
6isosorbide dinitrate44 49 1112.0AHSP, KCNJ5, EDN1
71,3-dimethyl-2-thiourea449.9CAT, EDN1, SOD1
8thiobarbituric acid449.9SOD1, SOD3, CAT
9trimetazidine449.9CAT, SOD1, EDN1
10ptio449.9NOS2, CAT, SOD1
11superoxide44 2410.8AHSP, AGTR1, OPRD1, SOD3, KCNJ5
12nadph44 2410.8AHSP, SOD3, SLC9A1, AGTR2
13prostaglandin449.8KCNJ5, AGTR2, AGTR1, AHSP
14captopril44 28 49 59 1113.8EDN1, AGTR2, AGTR1, AHSP
15nitrate449.7SOD3, EDN1, NOS2, KCNJ5
16glutamate449.7AGTR2, AGTR1, AHSP, OPRD1, KCNJ5
17ng-nitro-l-arginine449.7EDN1, AHSP, SOD1, NOS2
18xanthine44 2410.7AGTR2, CAT, SOD3, SOD1
198-isoprostane449.7SOD1, CAT, AGTR1, EDN1
20ang ii449.7AGTR2, EDN1, NOS2, AGTR1
21apocynin44 5910.6EDN1, NOS2, SOD1, CAT
22norepinephrine44 11 2411.6SLC9A1, AHSP, OPRD1, KCNJ5, AGTR2
23n(g)-nitro-l-arginine methyl ester449.6KCNJ5, SOD1, EDN1, NOS2, AHSP
24oxygen44 2410.5OPRD1, KCNJ5, SOD3, AGTR2, AHSP, NOS2
25silymarin449.5CAT, SOD1, NOS2, PTGS2
26phenylephrine44 28 11 2412.5NOS2, EDN1, AGTR1, AHSP
27cariporide449.5EDN1, SLC9A3R2, SLC9A1
28peroxynitrite449.5NOS2, SOD1, SOD3, CAT
29acetylcholine44 49 28 11 2413.5AHSP, AGTR1, OPRD1, SOD3, KCNJ5, NOS2
30s-nitroso-n-acetylpenicillamine449.5CAT, SOD1, EDN1, NOS2, AHSP
31cgmp44 2810.4AHSP, KCNJ5, EDN1, AGTR2, NOS2, AGTR1
32isoproterenol44 1110.4EDN1, AGTR1, AHSP, NOS2, OPRD1
33nitroglycerin44 1110.3KCNJ5, SOD1, AGTR1, AHSP, NOS2, EDN1
34thromboxane a244 2410.3PTGS2, AHSP, AGTR1, EDN1
35ebselen449.3CAT, SOD1, NOS2
36pdtc449.3NOS2, PTGS2, SOD1, CAT
37l-nmma449.2AGTR1, EDN1, SOD1, CAT, AHSP, NOS2
38potassium44 11 2411.2SLC9A1, AHSP, AGTR1, KCNJ5, TNNI3, OPRD1
39n acetylcysteine448.9SOD3, SOD1, NOS2, PTGS2, SERPINC1, AGTR1
40creatinine448.9TNNT2, TNNI3, SERPINC1, AGTR1, AGTR2, EDN1
41sodium nitroprusside448.8AHSP, KCNJ5, CAT, SOD3, SOD1, NOS2
42indomethacin44 59 28 1111.7EDN1, SOD1, CAT, KCNJ5, AGTR2, NOS2
43prostacyclin448.7SOD1, SERPINC1, PTGS2, NOS2, AHSP, AGTR1
44arginine448.5AHSP, NOS2, SERPINC1, SOD3, SOD1, OPRD1
45lactate448.5TNNI3, TNNT2, SOD1, SLC9A1, CAT, KCNJ5
46sodium44 249.5EDN1, OPRD1, KCNJ5, AGTR1, AGTR2, AHSP
47alanine448.5SOD3, SOD1, SERPINC1, SLC9A1, AGTR1, AGTR2
48lipid448.1SOD3, SOD1, CAT, KCNJ5, OPRD1, AGTR1
49nitric oxide44 11 249.5KCNJ5, CAT, PTGS2, NOS2, SLC9A3R2, AHSP
50calcium44 49 11 2410.4AHSP, KCNJ5, TNNT2, TNNI3, SLC9A1, OPRD1

GO Terms for genes affiliated with Myocardial Stunning

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16Gene Ontology
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Cellular components related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.6NOS2, SOD1, CAT
2troponin complexGO:0058619.6TNNI3, TNNT2

Biological processes related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR2, AGTR1
2hemoglobin metabolic processGO:02002710.2AHSP, CAT
3heart contractionGO:06004710.2SOD1, TNNI3
4removal of superoxide radicalsGO:01943010.2SOD1, SOD3
5response to copper ionGO:04668810.1SOD1, SOD3
6negative regulation of ATPase activityGO:03278010.1TNNI3, TNNT2
7elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.9AGTR1, EDN1
8regulation of blood pressureGO:0082179.8PTGS2, AGTR2, SOD1
9positive regulation of nitric oxide biosynthetic processGO:0454299.8EDN1, AGTR2, PTGS2
10positive regulation of smooth muscle contractionGO:0459879.8EDN1, PTGS2
11prostaglandin biosynthetic processGO:0015169.8EDN1, PTGS2
12superoxide anion generationGO:0425549.7SOD1, EDN1
13regulation of sensory perception of painGO:0519309.7SLC9A1, EDN1, OPRD1
14positive regulation of renal sodium excretionGO:0358159.6EDN1, AGTR2
15response to hypoxiaGO:0016669.6NOS2, EDN1, SOD3, CAT
16G-protein coupled receptor signaling pathwayGO:0071869.5OPRD1, EDN1, AGTR2, AGTR1

Molecular functions related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.0AGTR1, AGTR2
2troponin C bindingGO:0301729.8TNNT2, TNNI3
3superoxide dismutase activityGO:0047849.7SOD1, SOD3
4protein bindingGO:0055156.2SERPINC1, KCNJ5, SOD3, SOD1, TNNI3, OPRD1

Products for genes affiliated with Myocardial Stunning

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Sources for Myocardial Stunning

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet