MCID: MYC005
MIFTS: 52

Myocardial Stunning malady

Cardiovascular diseases category
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Summaries for Myocardial Stunning

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Wikipedia:65 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

MalaCards based summary: Myocardial Stunning is related to hypertension and pulmonary hypertension. An important gene associated with Myocardial Stunning is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds alpha-phenyl-n-tert-butylnitrone and pyrogallol have been mentioned in the context of this disorder. Affiliated tissues include heart, neutrophil and endothelial, and related mouse phenotypes are renal/urinary system and skeleton.

Aliases & Classifications for Myocardial Stunning

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH
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Myocardial Stunning, Aliases & Descriptions:

Name: Myocardial Stunning 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:9767
MeSH34 D017682

Related Diseases for Myocardial Stunning

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Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.4EDN1, AGTR1
2pulmonary hypertension30.1NOS2, AHSP, EDN1
3ischemia29.5SOD1, TNNT2, AHSP, KCNJ5, EDN1, CAT
4acute myocardial infarction29.5AGTR1, SLC9A1, CAT, SOD3, SERPINC1, TNNI3
5myocardial infarction29.4AGTR1, AGTR2, SLC9A3R2, SLC9A1, SOD3, SERPINC1
6endotheliitis10.5
7morphine dependence10.5OPRD1
8artery disease10.5
9hypermethioninemia10.4SOD1
10coronary thrombosis10.4SERPINC1
11hypertrophic cardiomyopathy10.4
12diabetic cataract10.4CAT
13renovascular hypertension10.4AGTR1, AHSP
14hyperaldosteronism10.3AGTR1, KCNJ5
15low renin hypertension10.3EDN1
16conn's syndrome10.3AGTR2, AGTR1
17familial restrictive cardiomyopathy10.3TNNI3, TNNT2
18eclampsia10.3SERPINC1
19aneurysm10.3
20hypoxia10.3
21blindness10.3
22cardiogenic shock10.3
23congestive heart failure10.3TNNT2, TNNI3
24sudden cardiac death multi-gene panels10.3KCNJ5, TNNT2, TNNI3
25vesicoureteral reflux10.3AGTR1, AGTR2
26coronary artery vasospasm10.3AHSP, EDN1
27familial hypertrophic cardiomyopathy10.3TNNI3, TNNT2
28raynaud disease10.2EDN1, AGTR1
29pneumoconiosis10.2CAT, SOD1
30cor pulmonale10.2AGTR1, EDN1
31intermediate coronary syndrome10.2SERPINC1, TNNI3, TNNT2
32esophagitis10.2CAT, SLC9A1
33senile cataract10.2SOD1, CAT
34hyperhomocysteinemia10.2SERPINC1, SOD3, SOD1
35pulmonary edema10.2
36cerebritis10.2
37cervicitis10.2
38colon cancer10.2
39coronary stenosis10.2
40hyperthyroidism10.2
41kidney disease10.2
42peritonitis10.2
43spontaneous coronary artery dissection10.2
44stress cardiomyopathy10.2
45portal hypertension10.1AGTR1, EDN1
46diabetic angiopathy10.1CAT, EDN1
47cerebrovascular disease10.1AGTR1, AGTR2, SERPINC1, KCNJ5
48peyronie's disease10.1NOS2, SOD1
49hyperinsulinism10.1EDN1, KCNJ5, AGTR1
50arteriosclerosis10.1EDN1, AHSP, SOD1

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to myocardial stunning

Symptoms for Myocardial Stunning

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Drugs & Therapeutics for Myocardial Stunning

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Drug clinical trials:

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Search NIH Clinical Center for Myocardial Stunning

Genetic Tests for Myocardial Stunning

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Anatomical Context for Myocardial Stunning

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MalaCards organs/tissues related to Myocardial Stunning:

32
Heart, Neutrophil, Endothelial, Brain, Colon, Kidney, Testes

Animal Models for Myocardial Stunning or affiliated genes

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Publications for Myocardial Stunning

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Articles related to Myocardial Stunning:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
Seizure-Induced Myocardial Stunning: A Possible Cardiac Link to Sudden Unexpected Death In Epilepsy (SUDEP). (25305671)
2014
2
CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction: a meta-analysis of prospective trials. (23575990)
2013
3
Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. (22994851)
2013
4
High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine. (23806450)
2013
5
Non-invasive ventilation for severe TRALI and myocardial stunning: report and literature review. (22869453)
2012
6
Nitric oxide has no obligatory role in isoflurane late preconditioning against myocardial stunning. (23044225)
2012
7
Complex I syndrome in myocardial stunning and the effect of adenosine. (21723387)
2011
8
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine. (20464430)
2010
9
Myocardial stunning after electroconvulsive therapy in patients with an apparently normal heart. (19225404)
2009
10
Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. (17719165)
2008
11
Ca2+ sensitizer superior to catecholamine during myocardial stunning? (18539040)
2008
12
Re: Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. (18506208)
2008
13
Myocardial stunning due to sudden emotional stress. (15877319)
2005
14
Effects of endogenous adenosine and adenosine receptor agonists on hypoxia-induced myocardial stunning in Guinea-pig atria and papillary muscles. (15076219)
2004
15
Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning. (15031126)
2004
16
Ischemic shortening of action potential duration as a result of KATP channel opening attenuates myocardial stunning by reducing calcium influx. (12190121)
2002
17
Increases in myocardial cyclic GMP attenuate contractile delay in myocardial stunning. (12269791)
2002
18
Clinical manifestations of myocardial stunning. (11491200)
2001
19
Myocardial stunning in exercise-induced ischemia in dogs: lack of late preconditioning. (11123245)
2001
20
Nitric oxide donors attenuate myocardial stunning in conscious rabbits. (10600874)
1999
21
In search of the proteins that cause myocardial stunning. (10473676)
1999
22
Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning. (10533603)
1999
23
Gated single-photon emission tomography imaging protocol to evaluate myocardial stunning after exercise. (10638404)
1999
24
Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway. (10600873)
1999
25
Aminoguanidine inhibits inducible NOS and reverses cardiac dysfunction late after ischemia and reperfusion--implications for iNOS-mediated myocardial stunning. (10443512)
1999
26
Effects of azelnidipine, a dihydropyridine calcium antagonist, on myocardial stunning in dogs. (9623715)
1998
27
17-Beta estradiol regulation of myocardial glutathione and its role in protection against myocardial stunning in dogs. (9733360)
1998
28
Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning. (9559621)
1998
29
Adenosine attenuates in vivo myocardial stunning with minimal effects on cardiac energetics. (9782373)
1998
30
Myocardial stunning--ups and downs in the Dolomites. (9689434)
1998
31
Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism. (9670920)
1998
32
Prospective identification of myocardial stunning using technetium-99m sestamibi-based measurements of infarct size. (9385887)
1997
33
Activation of adenosine receptors before ischemia enhances tolerance against myocardial stunning in the rabbit heart. (8522700)
1996
34
Do ATP-sensitive potassium channels play a role in myocardial stunning? (8534242)
1995
35
The effects of modulation of the L-arginine-nitric oxide pathway on myocardial stunning following repetitive coronary occlusion in dogs. (8857235)
1995
36
Commentary on myocardial stunning and its clinical relevance. (8534253)
1995
37
Myocardial stunning following respiratory arrest. (7587461)
1995
38
Diagnosis of myocardial stunning: a new use for myocardial contrast and dobutamine echocardiography. (8680143)
1995
39
Acute plaque rupture and myocardial stunning in patient with normal coronary arteriography. (7603266)
1995
40
Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide. (8087948)
1994
41
Inhibition of glycolysis or increased perfusate H+ buffering capacity, but not their combination, attenuates myocardial stunning. (8287444)
1993
42
Myocardial stunning and preconditioning: age, species, and model related differences: role of AMP-5'-nucleotidase in myocardial injury and protection. (8461514)
1993
43
Transient left ventricular dyskinesia as a consequence of myocardial stunning. (1442512)
1992
44
Prominent negative T waves with QT prolongation indicate reperfusion injury and myocardial stunning. (1339791)
1992
45
Myocardial stunning following coronary angioplasty: protective effects of calcium-channel blockers. (1282609)
1992
46
Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. (1423931)
1992
47
Cellular mechanisms of myocardial stunning. (1562175)
1992
48
Effects of an increase in intracellular free [Mg2+] after myocardial stunning on sarcoplasmic reticulum Ca2+ transport. (1884459)
1991
49
Effect of global myocardial stunning on Ca2(+)-sensitive myofibrillar ATPase activity and creatine kinase kinetics. (2144402)
1990
50
Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts. (3417873)
1988

Variations for Myocardial Stunning

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Expression for genes affiliated with Myocardial Stunning

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Expression patterns in normal tissues for genes affiliated with Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for genes affiliated with Myocardial Stunning

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Pathways related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9AGTR1, AGTR2
2
Show member pathways
Peptide GPCRs37
9.7OPRD1, AGTR2, AGTR1
3
Show member pathways
Vitamin B12 Metabolism37
9.5SOD3, SOD1, CAT
49.5SOD3, SOD1, CAT
5
Show member pathways
9.5CAT, SOD1, SOD3
69.5CAT, SOD1, SOD3
79.5NOS2, PTGS2
89.3TNNT2, TNNI3, SLC9A1
9
Show member pathways
9.3SOD1, CAT, NOS2
109.3NOS2, CAT, SOD1
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1NOS2, PTGS2, EDN1
12
Show member pathways
thioredoxin pathway37
9.0PTGS2, SOD3, SOD1, CAT
138.9SLC9A1, NOS2, PTGS2
148.8TNNT2, TNNI3, SLC9A1, AGTR2, AGTR1

Compounds for genes affiliated with Myocardial Stunning

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Compounds related to Myocardial Stunning according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1alpha-phenyl-n-tert-butylnitrone449.9CAT, SOD1, SOD3
2pyrogallol449.9SOD3, CAT, SOD1
3s-nitrosocysteine449.8NOS2, SOD1, AHSP
41,3-dimethyl-2-thiourea449.7EDN1, SOD1, CAT
5trimetazidine449.7EDN1, SOD1, CAT
6isosorbide dinitrate44 50 1111.7EDN1, KCNJ5, AHSP
7thiobarbituric acid449.7SOD3, SOD1, CAT
8captopril44 61 50 28 1113.6EDN1, AHSP, AGTR2, AGTR1
9diphenyliodonium449.6SOD1, CAT, NOS2
10ptio449.6NOS2, CAT, SOD1
11nitrate449.5EDN1, KCNJ5, NOS2, SOD3
12xanthine44 2410.5AGTR2, SOD3, SOD1, CAT
13ng-nitro-l-arginine449.4NOS2, SOD1, AHSP, EDN1
148-isoprostane449.4CAT, SOD1, EDN1, AGTR1
15ang ii449.4AGTR2, EDN1, NOS2, AGTR1
16n(g)-nitro-l-arginine methyl ester449.3NOS2, SOD1, AHSP, KCNJ5, EDN1
17apocynin44 6110.3SOD1, CAT, NOS2, EDN1
18prostaglandin449.2AGTR1, AGTR2, PTGS2, AHSP, KCNJ5
19phenylephrine44 28 24 1112.1EDN1, NOS2, AGTR1, AHSP
20s-nitroso-n-acetylpenicillamine449.1AHSP, NOS2, CAT, SOD1, EDN1
21silymarin449.1SOD1, CAT, NOS2, PTGS2
22cgmp44 2810.1AGTR1, NOS2, AHSP, KCNJ5, AGTR2, EDN1
23isoproterenol44 1110.0EDN1, OPRD1, NOS2, AGTR1, AHSP
24tetrahydrobiopterin44 24 1111.0PTGS2, SOD1, CAT, AHSP, NOS2
25nitroglycerin44 1110.0SOD1, KCNJ5, AGTR1, NOS2, EDN1, AHSP
26peroxynitrite449.0SOD3, SOD1, CAT, NOS2
27potassium44 24 1110.9KCNJ5, TNNI3, OPRD1, SLC9A1, AGTR1, AHSP
28cariporide448.9SLC9A1, EDN1, SLC9A3R2
29l-nmma448.8AHSP, EDN1, NOS2, SOD1, CAT, AGTR1
30pdtc448.8PTGS2, SOD1, CAT, NOS2
31acetylcholine44 50 28 24 1112.8OPRD1, AHSP, AGTR1, NOS2, SOD3, EDN1
32creatinine448.7TNNT2, SOD1, SERPINC1, AGTR2, TNNI3, EDN1
33norepinephrine44 24 1110.6OPRD1, AGTR1, AGTR2, SLC9A1, EDN1, KCNJ5
34heparin44 28 24 1111.5OPRD1, SOD3, SERPINC1, AHSP, TNNT2, AGTR1
35lactate448.5TNNT2, KCNJ5, SOD1, SLC9A1, CAT, TNNI3
36egcg448.5CAT, PTGS2, SOD1, SLC9A1, NOS2
37sodium nitroprusside448.4AHSP, KCNJ5, EDN1, SOD3, SOD1, CAT
38n acetylcysteine448.3AGTR1, NOS2, SOD1, SOD3, PTGS2, CAT
39alanine448.2AGTR1, AGTR2, TNNT2, SLC9A1, SERPINC1, SOD3
40glutamate448.2OPRD1, KCNJ5, AHSP, SOD1, AGTR1, AGTR2
41indomethacin44 28 61 1111.1AGTR2, KCNJ5, AHSP, PTGS2, SOD1, NOS2
42nadph44 249.1NOS2, AHSP, SOD3, SOD1, CAT, SLC9A1
43prostacyclin448.1SOD1, AGTR2, AGTR1, SERPINC1, PTGS2, AHSP
44arginine448.1AGTR2, EDN1, SOD3, AGTR1, NOS2, OPRD1
45sodium44 248.8SLC9A1, OPRD1, KCNJ5, EDN1, AGTR2, AHSP
46superoxide44 248.7OPRD1, CAT, SOD3, SOD1, AHSP, AGTR1
47lipid447.5AGTR1, SOD1, KCNJ5, AHSP, CAT, SOD3
48calcium44 50 24 119.8SLC9A1, AGTR2, AGTR1, EDN1, KCNJ5, AHSP
49oxygen44 247.7AGTR1, SLC9A1, NOS2, OPRD1, CAT, SOD1
50nitric oxide44 24 118.5EDN1, SOD1, AGTR1, AGTR2, SLC9A3R2, NOS2

GO Terms for genes affiliated with Myocardial Stunning

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Cellular components related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.6TNNI3, TNNT2
2peroxisomeGO:0057779.3NOS2, CAT, SOD1
3plasma membraneGO:0058866.9AGTR1, KCNJ5, SERPINC1, SOD1, CAT, OPRD1

Biological processes related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1angiotensin-activated signaling pathwayGO:03816610.3AGTR2, AGTR1
2renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR2, AGTR1
3negative regulation of ATPase activityGO:03278010.2TNNT2, TNNI3
4hemoglobin metabolic processGO:02002710.2CAT, AHSP
5heart contractionGO:06004710.2TNNI3, SOD1
6removal of superoxide radicalsGO:01943010.2SOD1, SOD3
7response to copper ionGO:04668810.1SOD1, SOD3
8positive regulation of renal sodium excretionGO:03581510.0EDN1, AGTR2
9positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.0EDN1, AGTR1
10superoxide anion generationGO:0425549.9EDN1, SOD1
11ventricular cardiac muscle tissue morphogenesisGO:0550109.9TNNI3, TNNT2
12regulation of vasoconstrictionGO:0192299.9EDN1, AGTR1
13nitric oxide mediated signal transductionGO:0072639.9NOS2, AGTR2
14prostaglandin biosynthetic processGO:0015169.7EDN1, PTGS2
15regulation of blood pressureGO:0082179.7AGTR2, SOD1, PTGS2
16positive regulation of smooth muscle contractionGO:0459879.7EDN1, PTGS2
17superoxide metabolic processGO:0068019.7SOD1, NOS2
18positive regulation of nitric oxide biosynthetic processGO:0454299.7AGTR2, PTGS2, EDN1
19G-protein coupled receptor signaling pathwayGO:0071869.6AGTR1, AGTR2, OPRD1, EDN1
20regulation of sensory perception of painGO:0519309.5SLC9A1, OPRD1, EDN1
21positive regulation of vasodilationGO:0459099.5AGTR2, NOS2
22regulation of pHGO:0068859.3SLC9A1, EDN1
23response to hypoxiaGO:0016669.3EDN1, SOD3, CAT, NOS2

Molecular functions related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.9TNNI3, TNNT2
2angiotensin type II receptor activityGO:0049459.8AGTR2, AGTR1
3superoxide dismutase activityGO:0047849.6SOD3, SOD1
4heme bindingGO:0200379.1NOS2, CAT, PTGS2
5protein bindingGO:0055156.1AGTR1, EDN1, KCNJ5, TNNI3, SERPINC1, SOD3

Products for genes affiliated with Myocardial Stunning

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Sources for Myocardial Stunning

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet