MCID: MYC005
MIFTS: 46

Myocardial Stunning malady

Summaries for Myocardial Stunning

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64Wikipedia, 33MalaCards
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Wikipedia:64 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

MalaCards: Myocardial Stunning is related to acute myocardial infarction and coronary artery disease,. An important gene associated with Myocardial Stunning is KCNJ5 (potassium inwardly-rectifying channel, subfamily J, member 5), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and Folate Metabolism. The compounds tetrahydrobiopterin and losartan have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and colon, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Aliases & Classifications for Myocardial Stunning

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH
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Aliases & Descriptions:

myocardial stunning 8 10 45 61


External Ids:

Disease Ontology8 DOID:9767
MeSH35 D017682

Related Diseases for Myocardial Stunning

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction30.7EDN1, AGTR1, AHSP, SLC9A1, SERPINC1, TNNI3
2coronary artery disease,30.6AHSP, EDN1, SLC9A1, KCNJ5, SOD3, AGTR1
3hypertrophic cardiomyopathy30.5TNNI3, TNNT2
4conn's syndrome30.2AGTR1, AGTR2
5stress cardiomyopathy10.5
6n syndrome10.4
7hypoxia10.3
8cardiogenic shock10.3
9pulmonary edema10.1
10drug induced dyskinesia10.1
11spontaneous coronary artery dissection10.1
12tako-tsubo cardiomyopathy10.1
13thalassemia10.0AHSP
14cystic fibrosis10.0SLC9A3R2
15malignant glioma10.0SLC9A1
16pneumonia10.0SOD3
17deficiency anemia10.0AHSP
18pheochromocytoma10.0AGTR2
19eclampsia10.0SERPINC1
20ureteral obstruction10.0AGTR1
21dementia10.0AGTR1
22purpura10.0SERPINC1
23nephrotic syndrome10.0SERPINC1
24obesity10.0KCNJ5, SLC9A1
25pulmonary embolism10.0SERPINC1
26thromboembolism10.0SERPINC1
27acute pancreatitis10.0SOD1
28bronchopulmonary dysplasia10.0SOD1
29mitral valve prolapse10.0AGTR1
30amyotrophic lateral sclerosis10.0SOD1
31pancreatitis10.0SOD1
32ovarian cancer10.0AGTR1
33hypoglycemia10.0OPRD1, KCNJ5
34hellp syndrome10.0SERPINC1
35hepatitis10.0CAT
36brain edema10.0SOD1
37infertility10.0CAT
38disseminated intravascular coagulation10.0SERPINC1
39leukemia10.0CAT
40astrocytoma10.0NOS2
41hypermethioninemia10.0SOD1
42stroke, ischemic10.0EDN1
43down syndrome10.0KCNJ5, SOD1
44renovascular hypertension10.0AHSP, AGTR1
45glaucoma10.0EDN1
46portal hypertension10.0EDN1
47vesicoureteral reflux10.0AGTR1, AGTR2
48esophagitis10.0SLC9A1, CAT
49eales disease10.0SOD1
50galactosemia10.0SERPINC1, CAT

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to myocardial stunning

Clinical Features for Myocardial Stunning

Drugs & Therapeutics for Myocardial Stunning

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myocardial Stunning

Drug clinical trials:

Search ClinicalTrials for Myocardial Stunning

Search NIH Clinical Center for Myocardial Stunning

Search CenterWatch for Myocardial Stunning

Genetic Tests for Myocardial Stunning

Anatomical Context for Myocardial Stunning

Sources:
33MalaCards
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MalaCards organs/tissues related to Myocardial Stunning:

33
Brain, Heart, Colon, Kidney, T cells, B cells, Endothelial

Animal Models for Myocardial Stunning or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myocardial Stunning

Sources:
51PubMed
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Articles related to Myocardial Stunning:

(show top 50)    (show all 429)
idTitleAuthorsYear
1
Isoflurane late preconditioning against myocardial stunning is associated with enhanced antioxidant defenses. (22103751)
2012
2
Complex I syndrome in myocardial stunning and the effect of adenosine. (21723387)
2011
3
Peritoneal dialysis is not associated with myocardial stunning. (20522673)
2011
4
DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. (20075143)
2010
5
Cardiac complications of ECT: myocardial stunning syndrome and takotsubo cardiomyopathy after ECT: different names for the same phenomenon. (20502202)
2010
6
Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen. (19203898)
2009
7
Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. (17719165)
2008
8
Re: Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. (18506208)
2008
9
Heart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament. (16470090)
2006
10
Pharmacologic treatment of heart failure due to ventricular dysfunction by myocardial stunning: potential role of levosimendan. (16555860)
2006
11
Usefulness of a comprehensive cardiovascular magnetic resonance imaging assessment for predicting recovery of left ventricular wall motion in the setting of myocardial stunning. (16256880)
2005
12
Rapid ventricular pacing induces delayed cardioprotection against myocardial stunning. (16242141)
2005
13
Prolonged myocardial stunning with adenosine infusion on gated SPECT imaging. (15472635)
2004
14
Usefulness of simultaneous evaluations of contractile reserve, perfusion, and metabolism during dobutamine stress for predicting wall motion reversibility (myocardial stunning) after successful PTCA. (15090696)
2004
15
Upregulation of angiotensin II type 2 receptor and limitation of myocardial stunning by angiotensin II type 1 receptor blockers during reperfused myocardial infarction in the rat. (14506547)
2003
16
Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don>t. (11991727)
2002
17
TY-12533, a novel Na(+)/H(+) exchange inhibitor, prevents myocardial stunning in dogs. (11348635)
2001
18
Maintained contractile reserve in a transgenic mouse model of myocardial stunning. (11356618)
2001
19
Enhanced cAMP-induced nitric oxide-dependent coronary dilation during myocardial stunning in conscious pigs. (11087254)
2000
20
Nitroprusside attenuates myocardial stunning through reduced contractile delay and time. (10719838)
2000
21
A mouse model of myocardial stunning. (10904251)
2000
22
Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning. (10533603)
1999
23
Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan. (10424239)
1999
24
Molecular and cellular mechanisms of myocardial stunning. (10221990)
1999
25
Myocardial stunning--ups and downs in the Dolomites. (9689434)
1998
26
Randomized, double-blind crossover study to investigate the effects of amlodipine and isosorbide mononitrate on the time course and severity of exercise-induced myocardial stunning. (9727544)
1998
27
Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved. (9593774)
1998
28
Is myocardial stunning of clinical importance? A surgeon's perspective. (9689441)
1998
29
Clonidine improves recovery from myocardial stunning in conscious chronically instrumented dogs. (9806673)
1998
30
Why myocardial stunning is clinically important. (9689442)
1998
31
Monophosphoryl lipid A attenuates myocardial stunning in dogs: role of ATP-sensitive potassium channels. (9676720)
1998
32
Aspirin does not prevent the attenuation of myocardial stunning by the ACE inhibitor ramiprilat. (9011643)
1996
33
Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. (8902873)
1996
34
Attenuation of myocardial stunning in isolated rat hearts by a 21-aminosteroid lazaroid (U74389G). (8945679)
1996
35
Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs. (9015403)
1996
36
Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine. (10603526)
1995
37
Free radicals, calcium homeostasis, heat shock proteins, and myocardial stunning. (7677533)
1995
38
Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide. (8087948)
1994
39
Prolonged wall motion abnormalities after chest pain at rest in patients with unstable angina: a possible manifestation of myocardial stunning. (8172052)
1994
40
Transvalvular left ventricular assistance in cardiogenic shock secondary to acute myocardial infarction. Evidence for recovery from near fatal myocardial stunning. (8113546)
1994
41
Volatile anesthetics and myocardial stunning. (8214685)
1993
42
Myocardial stunning and reperfusion injury in cardiac surgery. (8461524)
1993
43
The relationship between ischemia-reperfusion injury, myocardial stunning and cardiac preconditioning. (8322165)
1993
44
The pathophysiology of myocardial stunning: reversibility, accumulation and continuity of the ischemic myocardial damage after reperfusion. (1658410)
1991
45
Do neutrophils contribute to myocardial stunning? (1756137)
1991
46
Prostaglandin redirection by thromboxane synthetase inhibition. Attenuation of myocardial stunning in canine heart. (2297841)
1990
47
Reversal of segmental hypokinesis by coronary angioplasty in patients with unstable angina, persistent T wave inversion, and left anterior descending coronary artery stenosis. Additional evidence for myocardial stunning in humans. (2394011)
1990
48
Acute pulmonary edema caused by prolonged myocardial stunning after dipyridamole-thallium imaging. (2508472)
1989
49
Effects of transient coronary occlusion: experience with myocardial stunning and preconditioning. (2807863)
1989
50
Effect of repeated episodes of drug-induced ventricular dyskinesia on subsequent regional function in the dog: comparison with myocardial stunning produced by repeated coronary occlusions. (3584722)
1987

Genetic Variations for Myocardial Stunning

Expression for genes affiliated with Myocardial Stunning

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for genes affiliated with Myocardial Stunning

Sources:
50PharmGKB, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Myocardial Stunning

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Myocardial Stunning according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1tetrahydrobiopterin45 11 2412.3PTGS2, AHSP
2losartan45 50 29 1113.1EDN1
3alpha-phenyl-n-tert-butylnitrone4510.1SOD3, CAT, SOD1
4s-nitrosocysteine4510.1NOS2, AHSP, SOD1
5pyrogallol4510.0SOD1, SOD3, CAT
6isosorbide dinitrate45 50 1112.0AHSP, KCNJ5, EDN1
71,3-dimethyl-2-thiourea459.9CAT, EDN1, SOD1
8thiobarbituric acid459.9SOD1, SOD3, CAT
9trimetazidine459.9CAT, SOD1, EDN1
10ptio459.9NOS2, CAT, SOD1
11superoxide45 2410.8AHSP, AGTR1, OPRD1, SOD3, KCNJ5
12nadph45 2410.8AHSP, SOD3, SLC9A1, AGTR2
13prostaglandin459.8KCNJ5, AGTR2, AGTR1, AHSP
14captopril45 29 50 60 1113.8EDN1, AGTR2, AGTR1, AHSP
15nitrate459.7SOD3, EDN1, NOS2, KCNJ5
16glutamate459.7AGTR2, AGTR1, AHSP, OPRD1, KCNJ5
17ng-nitro-l-arginine459.7EDN1, AHSP, SOD1, NOS2
18xanthine45 2410.7AGTR2, CAT, SOD3, SOD1
198-isoprostane459.7SOD1, CAT, AGTR1, EDN1
20ang ii459.7AGTR2, EDN1, NOS2, AGTR1
21apocynin45 6010.6EDN1, NOS2, SOD1, CAT
22norepinephrine45 11 2411.6SLC9A1, AHSP, OPRD1, KCNJ5, AGTR2
23n(g)-nitro-l-arginine methyl ester459.6KCNJ5, SOD1, EDN1, NOS2, AHSP
24oxygen45 2410.5OPRD1, KCNJ5, SOD3, AGTR2, AHSP, NOS2
25silymarin459.5CAT, SOD1, NOS2, PTGS2
26phenylephrine45 29 11 2412.5NOS2, EDN1, AGTR1, AHSP
27cariporide459.5EDN1, SLC9A3R2, SLC9A1
28peroxynitrite459.5NOS2, SOD1, SOD3, CAT
29acetylcholine45 50 29 11 2413.5AHSP, AGTR1, OPRD1, SOD3, KCNJ5, NOS2
30s-nitroso-n-acetylpenicillamine459.5CAT, SOD1, EDN1, NOS2, AHSP
31cgmp45 2910.4AHSP, KCNJ5, EDN1, AGTR2, NOS2, AGTR1
32isoproterenol45 1110.4EDN1, AGTR1, AHSP, NOS2, OPRD1
33nitroglycerin45 1110.3KCNJ5, SOD1, AGTR1, AHSP, NOS2, EDN1
34thromboxane a245 2410.3PTGS2, AHSP, AGTR1, EDN1
35ebselen459.3CAT, SOD1, NOS2
36pdtc459.3NOS2, PTGS2, SOD1, CAT
37l-nmma459.2AGTR1, EDN1, SOD1, CAT, AHSP, NOS2
38potassium45 11 2411.2SLC9A1, AHSP, AGTR1, KCNJ5, TNNI3, OPRD1
39n acetylcysteine458.9SOD3, SOD1, NOS2, PTGS2, SERPINC1, AGTR1
40creatinine458.9TNNT2, TNNI3, SERPINC1, AGTR1, AGTR2, EDN1
41sodium nitroprusside458.8AHSP, KCNJ5, CAT, SOD3, SOD1, NOS2
42indomethacin45 60 29 1111.7EDN1, SOD1, CAT, KCNJ5, AGTR2, NOS2
43prostacyclin458.7SOD1, SERPINC1, PTGS2, NOS2, AHSP, AGTR1
44arginine458.5AHSP, NOS2, SERPINC1, SOD3, SOD1, OPRD1
45lactate458.5TNNI3, TNNT2, SOD1, SLC9A1, CAT, KCNJ5
46sodium45 249.5EDN1, OPRD1, KCNJ5, AGTR1, AGTR2, AHSP
47alanine458.5SOD3, SOD1, SERPINC1, SLC9A1, AGTR1, AGTR2
48lipid458.1SOD3, SOD1, CAT, KCNJ5, OPRD1, AGTR1
49nitric oxide45 11 249.5KCNJ5, CAT, PTGS2, NOS2, SLC9A3R2, AHSP
50calcium45 50 11 2410.4AHSP, KCNJ5, TNNT2, TNNI3, SLC9A1, OPRD1

GO Terms for genes affiliated with Myocardial Stunning

Sources:
16Gene Ontology
See all sources

Cellular components related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.6NOS2, SOD1, CAT
2troponin complexGO:0058619.6TNNI3, TNNT2

Biological processes related to Myocardial Stunning according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR2, AGTR1
2hemoglobin metabolic processGO:02002710.2AHSP, CAT
3heart contractionGO:06004710.2SOD1, TNNI3
4removal of superoxide radicalsGO:01943010.2SOD1, SOD3
5response to copper ionGO:04668810.1SOD1, SOD3
6negative regulation of ATPase activityGO:03278010.1TNNI3, TNNT2
7elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.9AGTR1, EDN1
8regulation of blood pressureGO:0082179.8PTGS2, AGTR2, SOD1
9positive regulation of nitric oxide biosynthetic processGO:0454299.8EDN1, AGTR2, PTGS2
10positive regulation of smooth muscle contractionGO:0459879.8EDN1, PTGS2
11prostaglandin biosynthetic processGO:0015169.8EDN1, PTGS2
12superoxide anion generationGO:0425549.7SOD1, EDN1
13regulation of sensory perception of painGO:0519309.7SLC9A1, EDN1, OPRD1
14positive regulation of renal sodium excretionGO:0358159.6EDN1, AGTR2
15response to hypoxiaGO:0016669.6NOS2, EDN1, SOD3, CAT
16G-protein coupled receptor signaling pathwayGO:0071869.5OPRD1, EDN1, AGTR2, AGTR1

Molecular functions related to Myocardial Stunning according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.0AGTR1, AGTR2
2troponin C bindingGO:0301729.8TNNT2, TNNI3
3superoxide dismutase activityGO:0047849.7SOD1, SOD3
4protein bindingGO:0055156.2SERPINC1, KCNJ5, SOD3, SOD1, TNNI3, OPRD1

Products for genes affiliated with Myocardial Stunning

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Sources for Myocardial Stunning

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet