Aliases & Classifications for Myocardial Stunning

MalaCards integrated aliases for Myocardial Stunning:

Name: Myocardial Stunning 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9767
MeSH 41 D017682
UMLS 69 C0206146

Summaries for Myocardial Stunning

MalaCards based summary : Myocardial Stunning is related to coronary artery anomaly and acute myocardial infarction, and has symptoms including medically unexplained symptoms, hypertriglyceridemic waist and prodromal symptoms. An important gene associated with Myocardial Stunning is SLC9A1 (Solute Carrier Family 9 Member A1), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Selenium Micronutrient Network. The drugs Hydroxocobalamin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and bone, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and cardiovascular system

Wikipedia : 72 In cardiology, stunned myocardium is a state when some section of the myocardium (corresponding to area... more...

Related Diseases for Myocardial Stunning

Diseases related to Myocardial Stunning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 30.0 AGTR1 EDN1 TNNI3
2 acute myocardial infarction 29.9 EDN1 SERPINC1 TNNI3 TNNT2
3 ventricular fibrillation, paroxysmal familial, 1 29.7 KCNJ5 SLC9A1 TNNT2
4 chronic kidney failure 29.6 AGTR1 EDN1 SOD1
5 myocardial infarction 29.5 AGTR1 EDN1 SERPINC1 TNNI3 TNNT2
6 arteries, anomalies of 29.3 AGTR1 EDN1 SERPINC1 TNNI3 TNNT2
7 ischemia 10.5
8 familial isolated restrictive cardiomyopathy 10.4 TNNI3 TNNT2
9 platelet aggregation, spontaneous 10.3 SERPINC1 SOD1
10 gas gangrene 10.3 TNNI3 TNNT2
11 anoxia 10.2 KCNJ5 SOD1
12 meningococcal infection 10.2 AGTR1 SOD1
13 meningitis and encephalitis 10.2 CAT SOD1
14 hepatic vascular disease 10.2 EDN1 SERPINC1
15 endotheliitis 10.1
16 aortic coarctation 10.1 AGTR1 EDN1
17 raynaud disease 10.1 AGTR1 EDN1
18 malignant hypertension 10.1 AGTR1 EDN1
19 familial isolated dilated cardiomyopathy 10.1 TNNI3 TNNT2
20 renal hypertension 10.1 AGTR1 EDN1
21 intermediate coronary syndrome 10.1 SERPINC1 TNNI3 TNNT2
22 pulmonary embolism 10.1 SERPINC1 TNNI3 TNNT2
23 familial hyperaldosteronism 10.1 AGTR1 KCNJ5
24 hydrops, lactic acidosis, and sideroblastic anemia 10.0
25 hypertrophic cardiomyopathy 10.0
26 retinal ischemia 10.0 CAT SOD1
27 acute mountain sickness 10.0 AGTR1 EDN1
28 diabetic angiopathy 10.0 CAT EDN1
29 intermittent claudication 10.0 SERPINC1 TNNT2
30 blood group, i system 9.9
31 aging 9.9
32 cardiac arrest 9.9
33 pulmonary edema 9.9
34 aneurysm 9.9
35 hypoxia 9.9
36 cardiogenic shock 9.9
37 ischemic optic neuropathy 9.9 AGTR1 EDN1 SERPINC1
38 nonarteritic anterior ischemic optic neuropathy 9.9 AGTR1 EDN1 SERPINC1
39 limb ischemia 9.8 EDN1 TNNI3
40 tetralogy of fallot 9.8 CAT EDN1 TNNT2
41 pheochromocytoma 9.8
42 stroke, ischemic 9.8
43 episodic pain syndrome, familial, 1 9.8
44 pulmonary hypertension 9.8
45 status epilepticus 9.8
46 epilepsy 9.8
47 cervicitis 9.8
48 cerebritis 9.8
49 coronary stenosis 9.8
50 kidney disease 9.8

Graphical network of the top 20 diseases related to Myocardial Stunning:



Diseases related to Myocardial Stunning

Symptoms & Phenotypes for Myocardial Stunning

UMLS symptoms related to Myocardial Stunning:


medically unexplained symptoms, hypertriglyceridemic waist, prodromal symptoms, mobility limitation, urological manifestations, hot flushes, renal colic, polydipsia, chills, skin manifestations, signs and symptoms, respiratory, signs and symptoms, digestive, signs and symptoms, oral manifestations, fatigue, eye manifestations, edema, cyanosis, body temperature changes, asthenia

GenomeRNAi Phenotypes related to Myocardial Stunning according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 9.02 EDN1 OPRD1 SOD3 TNNI3 TNNT2

MGI Mouse Phenotypes related to Myocardial Stunning:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 AGTR1 EDN1 KCNJ5 SERPINC1 SLC9A1 SOD1
2 homeostasis/metabolism MP:0005376 9.61 AGTR1 CAT EDN1 OPRD1 SERPINC1 SLC9A1
3 mortality/aging MP:0010768 9.28 AGTR1 CAT EDN1 SERPINC1 SLC9A1 SOD1

Drugs & Therapeutics for Myocardial Stunning

Drugs for Myocardial Stunning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Phase 4 13422-51-0 5460373 44475014 11953898
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
4
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
6
Ticagrelor Approved Phase 4 274693-27-5 9871419
7
Ranolazine Approved, Investigational Phase 4 95635-55-5, 142387-99-3 56959
8
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
9
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
12 Nutmeg Approved, Nutraceutical Phase 4
13 Simendan Investigational Phase 4 131741-08-7
14 Micronutrients Phase 4
15 Trace Elements Phase 4
16 Hematinics Phase 4
17 Vasodilator Agents Phase 4
18 Vitamin B 12 Phase 4
19 Vitamin B Complex Phase 4
20 Vitamins Phase 4
21 Anti-Arrhythmia Agents Phase 4
22 Pharmaceutical Solutions Phase 4
23 Phosphodiesterase Inhibitors Phase 4
24 Protective Agents Phase 4
25 Cardioplegic Solutions Phase 4
26 Adrenergic Agents Phase 4
27 Neurotransmitter Agents Phase 4
28 Peripheral Nervous System Agents Phase 4
29 Autonomic Agents Phase 4
30 Calcium, Dietary Phase 4
31 Chlorhexidine gluconate Phase 4
32 Atorvastatin Calcium Phase 4 134523-03-8
33 Rosuvastatin Calcium Phase 4 147098-20-2
34 Analgesics Phase 4
35 calcium channel blockers Phase 4
36 Fibrinolytic Agents Phase 4
37 Adrenergic Antagonists Phase 4
38 Adrenergic beta-1 Receptor Antagonists Phase 4
39 Adrenergic beta-Antagonists Phase 4
40 Sympatholytics Phase 4
41 Glucuronyl glucosamine glycan sulfate Phase 4
42 Cyclooxygenase Inhibitors Phase 4
43 Analgesics, Non-Narcotic Phase 4
44 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
45 Anticholesteremic Agents Phase 4
46 Anticoagulants Phase 4
47 Hypoglycemic Agents Phase 4
48 Hypolipidemic Agents Phase 4
49 Platelet Aggregation Inhibitors Phase 4
50 Antihypertensive Agents Phase 4

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Intracoronary Administration of Levosimendan in Cardiac Surgery Patients Unknown status NCT01500785 Phase 4 levosimendan;Vitamin B 12
2 The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy) Enrolling by invitation NCT02767401 Phase 4 aspirin, clopidogrel, ticagrelor, atorvastatin, rosuvastatin, betaloc
3 The Success of Opening Concurrent Chronic Total Occlusion leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease Enrolling by invitation NCT03372785 Phase 4 aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor
4 Ranolazine a Potential New Therapeutic Application Not yet recruiting NCT02687269 Phase 4 Ranolazine;Placebo
5 Serial Echocardiography After Subarachnoid Hemorrhage Unknown status NCT00123695
6 Myocardial Stunning During Hemodialysis: Role of Dialyste Calcium Concentration Completed NCT02545426
7 Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome Completed NCT00586183
8 Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study) Completed NCT00213746
9 Exercise-induced Changes in Cardiac Function & Morphology Completed NCT01179802
10 Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease Completed NCT00001528
11 Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients Recruiting NCT02145260 Lower dialysate sodium (138 mmol/L; using Renasol hemodialysis concentrate);Higher dialysate sodium (142 mmol/L; using Renasol hemodialysis concentrate)
12 Clinical Study of Liraglutide in Improving Cardiac Function for Patients With Ischemic Cardiomyopathy Enrolling by invitation NCT02930265 Liraglutide
13 Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation. Not yet recruiting NCT02770183
14 Risk Assessment by Cardiovascular Biomarkers in Chronic Dialysis Patients Not yet recruiting NCT02207153
15 EUROpean Intracoronary Cooling in Patients With ST-Elevation Myocardial Infarction Not yet recruiting NCT03447834
16 Steroid-induced Reduction of Surgical Stress Study Withdrawn NCT00807521 Dexamethasone;Placebo

Search NIH Clinical Center for Myocardial Stunning

Cochrane evidence based reviews: myocardial stunning

Genetic Tests for Myocardial Stunning

Anatomical Context for Myocardial Stunning

MalaCards organs/tissues related to Myocardial Stunning:

38
Heart, Eye, Bone, Neutrophil, Skin, Endothelial, Kidney

Publications for Myocardial Stunning

Articles related to Myocardial Stunning:

(show top 50) (show all 427)
# Title Authors Year
1
Current interpretation of myocardial stunning. ( 29221768 )
2017
2
Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT. ( 29119373 )
2017
3
Myocardial stunning occurs during intermittent haemodialysis for acute kidney injury. ( 28352974 )
2017
4
Myocardial stunning by gated SPECT: An old tool reinvented in a stunning turn. ( 29139036 )
2017
5
Editorial commentary: Interpreting and dealing with myocardial stunning. ( 29221767 )
2017
6
Parafascicular nucleus-heart neural crosstalk: Implications for seizure-induced myocardial stunning. ( 27539366 )
2016
7
Pentobarbital-Induced Myocardial Stunning in Status Epilepticus Requiring Extracorporeal Membrane Oxygenation: A Case Report and Literature Review. ( 27529037 )
2016
8
Citric Acid Cycle Metabolites Predict the Severity of Myocardial Stunning and Mortality in Newborn Pigs. ( 27741040 )
2016
9
Doppler echocardiographic myocardial stunning index predicts recovery of left ventricular systolic function after primary percutaneous coronary intervention. ( 27543440 )
2016
10
Hemodialysis-Induced Myocardial Stunning: A Review. ( 26290919 )
2015
11
Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest. ( 26275089 )
2015
12
Reply to the letter "Post-ischemic myocardial stunning was the starting point of takotsubo syndrome: Restitution is justified after falling down on". ( 26285184 )
2015
13
Post-ischemic myocardial stunning was the starting point of takotsubo syndrome: Restitution is justified after falling down on. ( 26163910 )
2015
14
Acute intraoperative neurogenic myocardial stunning during intracranial endoscopic fenestration and shunt revision in a pediatric patient. ( 26314948 )
2015
15
Prevention of myocardial stunning during percutaneous coronary interventions: novel insights from pre-treatment with glucagon-like peptide-1. ( 25700753 )
2015
16
CASE 0-2015 Problem-Solving in Transcatheter Aortic Valve Replacement: Cardiovascular Collapse, Myocardial Stunning, and Mitral Regurgitation. ( 26119409 )
2015
17
Ivabradine reduces myocardial stunning in patients with exercise-inducible ischaemia. ( 26419678 )
2015
18
Seizure-Induced Myocardial Stunning: A Possible Cardiac Link to Sudden Unexpected Death In Epilepsy (SUDEP). ( 25305671 )
2014
19
Myocardial stunning after resuscitation from cardiac arrest following spinal anaesthesia. ( 24963188 )
2014
20
Clinical characteristics of myocardial stunning in acute stroke. ( 25022725 )
2014
21
Rare giant T-wave inversions associated with myocardial stunning: report of 2 cases. ( 25068953 )
2014
22
Isolated Pulmonary Edema without Myocardial Stunning in Brainstem Strokes. ( 26322335 )
2014
23
Takotsubo and Takotsubo-like syndrome: a common neurogenic myocardial stunning pathway? ( 23058349 )
2013
24
Reversible T-Wave Inversions and Neurogenic Myocardial Stunning in a Patient with Recurrent Stress-Induced Cardiomyopathy. ( 24147830 )
2013
25
Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury. ( 23161879 )
2013
26
High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine. ( 23806450 )
2013
27
Spontaneous coronary artery dissection triggered post-ischemic myocardial stunning and takotsubo syndrome: two different names for the same condition. ( 23273747 )
2013
28
CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction: a meta-analysis of prospective trials. ( 23575990 )
2013
29
Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery before hypothermic cardioplegia. ( 23422047 )
2013
30
N-terminal Pro-B-type natriuretic peptide and its correlation to haemodialysis-induced myocardial stunning. ( 23880872 )
2013
31
Myocardial bridging, apical ballooning syndrome and myocardial stunning: shall we connect the dots? ( 23647592 )
2013
32
Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. ( 22994851 )
2013
33
Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. ( 22263852 )
2012
34
Postischemic myocardial stunning is superior to transient ischemic dilation for detecting multivessel coronary artery disease. ( 22185710 )
2012
35
Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: myocardial stunning or subendocardial hypoperfusion? ( 22565241 )
2012
36
Isoflurane late preconditioning against myocardial stunning is associated with enhanced antioxidant defenses. ( 22103751 )
2012
37
Stress cardiomyopathy: a syndrome of catecholamine-mediated myocardial stunning? ( 22297544 )
2012
38
Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients. ( 22822013 )
2012
39
Pathophysiology and pathogenesis of post-resuscitation myocardial stunning. ( 21584712 )
2012
40
Huge negative T waves reaching a depth of 36 mm below the isoelectric line on ECG associated with myocardial stunning. ( 22126257 )
2012
41
Nitric oxide has no obligatory role in isoflurane late preconditioning against myocardial stunning. ( 23044225 )
2012
42
Non-invasive ventilation for severe TRALI and myocardial stunning: report and literature review. ( 22869453 )
2012
43
Myocardial Stunning with Hemodialysis: Clinical Challenges of the Cardiorenal Patient. ( 22851961 )
2012
44
Investigation of myocardial stunning after cardiopulmonary resuscitation in pigs. ( 21565687 )
2011
45
Individualised dialysate temperature improves intradialytic haemodynamics and abrogates haemodialysis-induced myocardial stunning, without compromising tolerability. ( 21346338 )
2011
46
Reversible myocardial stunning due to carbon monoxide exposure. ( 21556453 )
2011
47
Dialysis-induced myocardial stunning: the other side of the cardiorenal syndrome. ( 21546884 )
2011
48
Frequent hemodialysis schedules are associated with reduced levels of dialysis-induced cardiac injury (myocardial stunning). ( 21597028 )
2011
49
Distinct effects of acute pretreatment with lipophilic and hydrophilic statins on myocardial stunning, arrhythmias and lethal injury in the rat heart subjected to ischemia/reperfusion. ( 22106818 )
2011
50
Early detection of myocardial stunning using low-dose dobutamine magnetic resonance imaging. ( 21402349 )
2011

Variations for Myocardial Stunning

Expression for Myocardial Stunning

Search GEO for disease gene expression data for Myocardial Stunning.

Pathways for Myocardial Stunning

GO Terms for Myocardial Stunning

Cellular components related to Myocardial Stunning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 9.32 TNNI3 TNNT2
2 T-tubule GO:0030315 9.26 KCNJ5 SLC9A1
3 troponin complex GO:0005861 9.16 TNNI3 TNNT2
4 cardiac myofibril GO:0097512 8.96 TNNI3 TNNT2
5 cardiac Troponin complex GO:1990584 8.62 TNNI3 TNNT2

Biological processes related to Myocardial Stunning according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.76 CAT EDN1 SOD3
2 response to oxidative stress GO:0006979 9.7 CAT SOD1 SOD3
3 cardiac muscle contraction GO:0060048 9.62 TNNI3 TNNT2
4 response to activity GO:0014823 9.62 CAT EDN1
5 muscle filament sliding GO:0030049 9.61 TNNI3 TNNT2
6 regulation of mitochondrial membrane potential GO:0051881 9.61 OPRD1 SOD1
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.6 AGTR1 EDN1
8 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.59 TNNI3 TNNT2
9 regulation of vasoconstriction GO:0019229 9.58 AGTR1 EDN1
10 positive regulation of cardiac muscle hypertrophy GO:0010613 9.57 EDN1 SLC9A1
11 superoxide metabolic process GO:0006801 9.56 SOD1 SOD3
12 regulation of pH GO:0006885 9.55 EDN1 SLC9A1
13 regulation of muscle contraction GO:0006937 9.54 TNNI3 TNNT2
14 cellular response to hypoxia GO:0071456 9.54 EDN1 OPRD1 SLC9A1
15 response to copper ion GO:0046688 9.51 SOD1 SOD3
16 response to muscle stretch GO:0035994 9.49 EDN1 SLC9A1
17 superoxide anion generation GO:0042554 9.48 EDN1 SOD1
18 heart contraction GO:0060047 9.46 SOD1 TNNI3
19 removal of superoxide radicals GO:0019430 9.43 SOD1 SOD3
20 cellular response to oxidative stress GO:0034599 9.43 CAT SOD1 SOD3
21 response to reactive oxygen species GO:0000302 9.4 CAT SOD1
22 negative regulation of ATPase activity GO:0032780 9.32 TNNI3 TNNT2
23 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.16 SLC9A1 TNNI3
24 response to ozone GO:0010193 8.96 CAT EDN1
25 regulation of sensory perception of pain GO:0051930 8.8 EDN1 OPRD1 SLC9A1

Molecular functions related to Myocardial Stunning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2B binding GO:0030346 9.26 SLC9A1 SOD1
2 superoxide dismutase activity GO:0004784 9.16 SOD1 SOD3
3 troponin C binding GO:0030172 8.96 TNNI3 TNNT2
4 antioxidant activity GO:0016209 8.8 CAT SOD1 SOD3

Sources for Myocardial Stunning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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