MCID: MYC008
MIFTS: 51

Myocarditis malady

Summaries for Myocarditis

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64Wikipedia, 33MalaCards
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Wikipedia:64 Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle (myocardium). more...

MalaCards: Myocarditis, also known as myocarditis, unspecified, is related to acute myocarditis and acute myocardial infarction. An important gene associated with Myocarditis is MYH6 (myosin, heavy chain 6, cardiac muscle, alpha), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Myocarditis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 40NCIt, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

myocarditis 8 43 10 45 61
myocarditis, unspecified 8
myocardial inflammation 8
myocarditis nos 8


External Ids:

Disease Ontology8 DOID:820
ICD9CM27 429.0
NCIt40 C34831
MeSH35 D009205

Related Diseases for Myocarditis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

acute myocarditis autoimmune myocarditis
infectious myocarditis post-infectious myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis31.7TNC, TXN
2acute myocardial infarction30.8TXN, TNC, PTX3
3systemic lupus erythematosus30.4LCN2, ICOS, CIITA, CD70, IL10RA, IL12RB1
4hepatitis c30.1TXN, CIITA, IL2
5arthritis30.0NOS2, CXCL2, CIITA, TXN
6celiac disease30.0CIITA
7thyroiditis29.9CIITA
8asthma29.7NOS2, IL12RB1, CIITA, TNC, LCN2
9sepsis29.7PTX3, NOS2, CXCL2, CIITA, TXN
10tuberculosis29.7CIITA, IL12RB1, IL2
11adenocarcinoma29.7LCN2, TNC, CXADR, IL10RA, NOS2
12vasculitis29.7PTX3, LCN2
13nephritis29.7LCN2
14wegener's granulomatosis29.7CIITA
15septic shock29.7CIITA, NOS2, PTX3
16autoimmune myocarditis11.1
17giant cell myocarditis10.9
18rheumatic myocarditis10.6
19interstitial myocarditis10.5
20infectious myocarditis10.5
21toxic myocarditis10.5
22atrioventricular block10.4
23thymoma10.4
24fiedler's myocarditis10.4
25cardiogenic shock10.3
26churg-strauss syndrome10.2
27polymyositis10.2
28trichinosis10.2
29cardiac tamponade10.2
30diphtheria10.2
31septic myocarditis10.2
32kawasaki disease10.2
33ulcerative colitis10.1
34hypertrophic cardiomyopathy10.1
35tonsillitis10.1
36adult-onset still's disease10.1
37n syndrome10.1
38cardiac sarcoidosis10.1
39chagas disease10.1
40infectious mononucleosis10.1
41hypereosinophilic syndrome10.1
42post-infectious myocarditis10.1
43syncope10.1
44mitral valve prolapse10.0
45relapsing polychondritis10.0
46dengue hemorrhagic fever10.0
47endocardial fibroelastosis10.0
48peripartum cardiomyopathy10.0
49typhoid fever10.0
50scrub typhus10.0

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to myocarditis

Clinical Features for Myocarditis

Drugs & Therapeutics for Myocarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Myocarditis

Drug clinical trials:

Search ClinicalTrials for Myocarditis

Search NIH Clinical Center for Myocarditis

Search CenterWatch for Myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

Animal Models for Myocarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Myocarditis

Sources:
51PubMed
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Articles related to Myocarditis:

(show top 50)    (show all 1547)
idTitleAuthorsYear
1
Diagnosis of viral myocarditis by cardiac magnetic resonance and viral genome detection in peripheral blood. (22562417)
2013
2
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy. (23964077)
2013
3
Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management. (23114995)
2013
4
Loeffler myocarditis in pre-B acute lymphoblastic leukaemia with t(5;14)(q31;q32). (22436047)
2012
5
Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis. (22617620)
2012
6
The role of extracorporeal life support in acute myocarditis: a bridge to recovery? (23441561)
2012
7
Use of intravenous immunoglobulin compared with standard therapy is associated with improved clinical outcomes in children with acute encephalitis syndrome complicated by myocarditis. (22588459)
2012
8
A case of viral myocarditis presenting with acute asthma attack. (22719812)
2012
9
Acute Q fever myocarditis: thinking about a life-threatening but potentially curable condition. (22078989)
2012
10
A case of acute myocarditis as the initial presentation of Crohn's disease. (23170159)
2012
11
Interferon-I^ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis. (23058369)
2012
12
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
13
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
14
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
15
Immunohistochemical and molecular-pathological diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS)--a multicenter study. (19282217)
2009
16
Cardiogenic shock in a neonate with enterovirus myocarditis. (20013569)
2009
17
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. (18760191)
2008
18
Cytomegalovirus-induced pneumonia and myocarditis in three cases of suspected sudden infant death syndrome (SIDS): diagnosis by immunohistochemical techniques and molecularpathologic methods. (17566679)
2008
19
Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. (18403598)
2008
20
Genetic differences in bone marrow-derived lymphoid lineages control susceptibility to experimental autoimmune myocarditis. (18490748)
2008
21
Naloxone, an opiate receptor antagonist, ameliorates acute experimental autoimmune myocarditis by reducing cytotoxic activities. (19033824)
2008
22
An infectious myocarditis syndrome affecting late-term and neonatal piglets. (15359968)
2004
23
An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. (14613869)
2003
24
Risks versus benefits of NSAIDs including aspirin in myocarditis: a review of the evidence from animal studies. (14583071)
2003
25
Thoratec left ventricular assist device for bridging to recovery in fulminant acute myocarditis. (12118766)
2002
26
Cardiac troponin T: its role in the diagnosis of clinically suspected acute myocarditis and chronic dilated cardiomyopathy in children. (12211203)
2002
27
Role of cytokines in autoimmune myocarditis and cardiomyopathy. (11908773)
2001
28
Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction. (11136679)
2001
29
Experimental autoimmune myocarditis and its pathomechanism. (10904852)
2000
30
Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis. (11028485)
2000
31
Echocardiographic findings in fulminant and acute myocarditis. (10898439)
2000
32
Myosin-induced autoimmune myocarditis in BALB/C mice. (12840852)
1999
33
A case of giant cell myocarditis and malignant thymoma: a postmortem diagnosis by needle biopsy. (9474466)
1998
34
Experimental autoimmune myocarditis produced by adoptive transfer of splenocytes after myocardial infarction. (9506706)
1998
35
Expression of inducible nitric oxide synthase in rat experimental autoimmune myocarditis with special reference to changes in cardiac hemodynamics. (8978317)
1997
36
Detection of viral genomes in myocarditis]. (7739117)
1995
37
Experimental autoimmune myocarditis: a suitable model to study neuroimmune crosstalk. (8729293)
1995
38
Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis. (1639508)
1992
39
Reye's syndrome associated with acute myocarditis and fatal circulatory failure. (1758777)
1991
40
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
41
Evaluation of mild acute infectious myocarditis. (6121567)
1982
42
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
43
Giant cell myocarditis and myositis. Associated with thymoma and myasthenia gravis. (5822053)
1969
44
Infectious myocarditis. (5678976)
1968
45
Mitral stenosis together with a giant cell myocarditis limited to the left atrium. (5717546)
1968
46
Primary interstitial myocarditis; report of an epidemic outbreak. (13544732)
1958
47
Fatal cardiac failure due to acute myocarditis of uncertain etiology. (13394198)
1956
48
Trichinosis; report of case manifesting myocarditis, encephalitis and radial neuritis; response to ACTH; review of literature regarding the erythrocyte sedimentation rate. (13159077)
1954
49
Acute myocarditis. (14779586)
1950
50
Primary streptococcic peritonitis with complicating toxic myocarditis and pulmonary emboli; a report of a case with eventual recovery. (18896519)
1947

Genetic Variations for Myocarditis

Expression for genes affiliated with Myocarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for genes affiliated with Myocarditis

Sources:
52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Myocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0TNC, TNFRSF9, TNFSF9, MYH6, CXCL2, IL10RA
2
Hide members
10.9TNFRSF9, TNFSF9, CD70, CXCL2, IL10RA, IL12RB1
3
Hide members
10.9IL12RB1, IL10RA, CXADR, MYH6, CIITA, ICOS
4
Hide members
10.8TNFRSF9, TNFSF9, MYH6, CXCL2, IL10RA, IL12RB1
5
Hide members
10.8TNFRSF9, TNFSF9, CXCL2, IL10RA, IL12RB1, IL2
6
Hide members
10.8TXN, ICOS, CIITA, CD274, CXADR, IL2
7
Hide members
10.8CIITA, IL10RA, IL12RB1, IL2, NOS2
8
Development PDGF signaling via STATs and NF-kB
Hide members
10.7IL10RA, IL12RB1, IL2, NOS2
910.7NOS2, IL2, CXCL2

Compounds for genes affiliated with Myocarditis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
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Compounds related to Myocarditis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.4LCN2, TNC, TNFRSF9, CIITA, CXADR, CXCL2
2nitric oxide45 11 2413.2LCN2, CIITA, CD274, CXADR, CXCL2, NOS2
3dexamethasone45 50 29 1114.2PTX3, TXN, TNFRSF9, CIITA, CXADR, CXCL2
4actinomycin d4511.1TXN, TNC, CIITA, IL2, NOS2, PTX3
5ionomycin4511.1TNFRSF9, CD274, CD70, IL12RB1, IL2
6serine4511.1TXN, CIITA, MYH6, CXADR, CXCL2
7oxygen45 2412.0TXN, LCN2, CIITA, MYH6, CXCL2, NOS2
8estrogen4510.9TXN, LCN2, TNC, MYH6, CXCL2, NOS2
9polyinosinic-polycytidylic acid4510.9CIITA, IL2, NOS2
10ccl345 2911.9PTX3, CXCL2, TNFRSF9
11rantes4510.9CIITA, CXCL2, IL2
12neomycin4510.8IL2, CXADR, MYH6
13fotemustine45 1111.8IL2, TXN
14taurine chloramine4510.6NOS2, IL2
15glatiramer acetate45 1111.6IL2, CIITA
16toxin-14510.5CIITA, IL2
17gold sodium thiomalate4510.3IL2, TXN

GO Terms for genes affiliated with Myocarditis

Sources:
16Gene Ontology
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Cellular components related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9CXADR, LCN2, TNC, TNFRSF9, TNFSF9, CD70
2external side of plasma membraneGO:00989710.7IL12RB1, CD274, TNFRSF9, ICOS
3extracellular regionGO:00557610.7PTX3, TXN, IL2, CXCL2, CXADR, TNC

Biological processes related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.0IL2, ICOS, TNFSF9, CIITA, CD274, CD70
2signal transductionGO:00716510.7TXN, TNFSF9, CD274, CD70, IL10RA, IL12RB1
3cell-cell signalingGO:00726710.7TXN, TNFSF9, CD70, IL2
4cardiac muscle fiber developmentGO:04873910.7CXADR, MYH6
5positive regulation of activated T cell proliferationGO:04210410.6IL2, IL12RB1
6protein homotrimerizationGO:07020710.3TNFRSF9, LCN2

Molecular functions related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.7NOS2, CXADR, CD70, TNFSF9

Products for genes affiliated with Myocarditis

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  • Lysates
  • Antibodies

Sources for Myocarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet