MCID: MYC008
MIFTS: 53

Myocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Myocarditis

Summaries for Myocarditis

NIH Rare Diseases : 50 myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). some affected people have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. it can also be associated with other inflammatory conditions such as lupus, wegener's granulomatosis, giant cell arteritis and takayasu's arteritis. most cases occur sporadically in people with no family history of the condition. treatment aims to address the underlying cause of the condition. medications and rarely, a heart transplant may be needed if the heart muscle becomes weak. last updated: 3/15/2016

MalaCards based summary : Myocarditis, also known as myocardial inflammation, is related to systemic lupus erythematosus and glomerulonephritis. An important gene associated with Myocarditis is DMD (Dystrophin), and among its related pathways/superpathways are Viral myocarditis and Innate Immune System. The drugs Adalimumab and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

Disease Ontology : 12 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Wikipedia : 72 Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms... more...

Related Diseases for Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
id Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 29.8 CD40 CD40LG CD86 HLA-DQB1 ICAM1 TNF
2 glomerulonephritis 29.4 DMD MB TNNI3
3 myocardial infarction 29.1 CD40LG ICAM1 MB NPPB TNF TNNI3
4 malaria 29.1 CD40 CD40LG CD55 HLA-B ICAM1 NOS2
5 giant cell myocarditis 12.3
6 autoimmune myocarditis 12.2
7 rheumatic myocarditis 12.1
8 acute myocarditis 12.1
9 fiedler's myocarditis 12.1
10 septic myocarditis 11.9
11 interstitial myocarditis 11.9
12 toxic myocarditis 11.9
13 infectious myocarditis 11.9
14 post-infectious myocarditis 11.7
15 trichinosis 11.3
16 diphtheria 11.3
17 chagas disease 11.1
18 spondylometaphyseal dysplasia, sedaghatian type 10.8
19 odontoma-dysphagia syndrome 10.8
20 trichosporonosis 10.7 CD40 CD86 TNF
21 moved to 614436 10.7 CD40 CD40LG
22 hodgkin's lymphoma, nodular sclerosis 10.7 CD40LG ICAM1
23 uveitis 10.7 CD40LG ICAM1 TNF
24 dermatomycosis 10.7 CD40LG ICAM1 TNF
25 spinal polio 10.7 CD40 CD40LG CD86
26 dracunculiasis 10.7 CD40LG ICAM1 TNF
27 acute vascular insufficiency of intestine 10.7 CD40LG ICAM1 TNF
28 conduct disorder 10.7 CD40LG ICAM1 TNF
29 pseudovascular skin squamous cell carcinoma 10.7 CD40LG MB
30 pyridoxine deficiency 10.7 CD40LG ITGB2 TNF
31 tick-borne encephalitis 10.7 CD40LG ICAM1 TNF
32 autosomal recessive nonsyndromic deafness 3 10.7 DAG1 DMD
33 epb42-related hereditary spherocytosis 10.7 DMD NOS2 TNF
34 acute interstitial pneumonia 10.6 CD40LG ICAM1 TNF
35 disease of mental health 10.6 CD40LG HLA-B TNF
36 human monocytic ehrlichiosis 10.6 CD40LG HLA-DQB1 TNF
37 eye carcinoma in situ 10.6 CD40LG HLA-B TNF
38 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.6 HLA-B HLA-DQB1 TNF
39 chromoblastomycosis 10.6 ICAM1 NOS2 TNF
40 psoriasis susceptibility 1 10.6 CD40LG HLA-B TNF
41 choreatic disease 10.6 CD40LG HLA-DQB1 TNF
42 acute cholangitis 10.6 CD40LG HLA-B TNF
43 anaerobic meningitis 10.6 HLA-B HLA-DQB1 TNF
44 emphysema, congenital lobar 10.6 CD40LG HLA-B TNF
45 gigantism 10.6 HLA-B MB
46 brown's tendon sheath syndrome 10.6 CD40LG NOS2
47 bolivian hemorrhagic fever 10.6 DSP ICAM1 TNF
48 acute chest syndrome 10.6 CD40LG ICAM1 TNF
49 migraine with brainstem aura 10.6 HLA-B TNF
50 biemond syndrome 10.6 HLA-DQB1 TNF

Comorbidity relations with Myocarditis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Myocardial Ischemia
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to Myocarditis

Symptoms & Phenotypes for Myocarditis

GenomeRNAi Phenotypes related to Myocarditis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 ICAM1 NOS2 TNF CD40LG DAG1 HLA-DQB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 ICAM1 NOS2 TNF CD40 CD40LG DAG1

MGI Mouse Phenotypes related to Myocarditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
2 cellular MP:0005384 10.25 ICAM1 ITGB2 MB NOS2 TNF TXN
3 behavior/neurological MP:0005386 10.22 CD55 CD86 CXADR DAG1 DMD HLA-DQB1
4 hematopoietic system MP:0005397 10.18 MB NOS2 TNF CD40 CD40LG CD55
5 homeostasis/metabolism MP:0005376 10.17 ICAM1 IL12RB1 ITGB2 MB MYH6 NOS2
6 endocrine/exocrine gland MP:0005379 10.06 CD40 CD40LG CD86 CXADR DMD HLA-DQB1
7 immune system MP:0005387 10 CD40 CD40LG CD86 CXADR DMD HLA-DQB1
8 mortality/aging MP:0010768 10 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
9 muscle MP:0005369 9.73 MB MYH6 NOS2 TNF TNNI3 CD86
10 respiratory system MP:0005388 9.17 CXADR DMD HLA-DQB1 MB NOS2 TNF

Drugs & Therapeutics for Myocarditis

Drugs for Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4 331731-18-1 16219006
2
Certolizumab pegol Approved Phase 4 428863-50-7
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Infliximab Approved Phase 4 170277-31-3
5
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2
7
Azathioprine Approved Phase 3 446-86-6 2265
8
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
9
Colchicine Approved Phase 3 64-86-8 6167 2833
10 Anti-Inflammatory Agents Phase 3,Phase 2
11 Antimetabolites Phase 3
12 Antimetabolites, Antineoplastic Phase 3
13 Antineoplastic Agents, Hormonal Phase 3,Phase 2
14 glucocorticoids Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Immunosuppressive Agents Phase 3,Phase 2
19 Ferrosoferric Oxide Phase 2, Phase 3
20 Hematinics Phase 2, Phase 3
21 Parenteral Nutrition Solutions Phase 2, Phase 3
22 Pharmaceutical Solutions Phase 2, Phase 3
23 Adrenergic Agents Phase 2, Phase 3
24 Adrenergic Antagonists Phase 2, Phase 3
25 Adrenergic beta-Antagonists Phase 2, Phase 3
26 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
27 Neurotransmitter Agents Phase 2, Phase 3
28 Anti-Arrhythmia Agents Phase 3
29 Antimitotic Agents Phase 3
30
Iron Approved Phase 2 7439-89-6 23925
31
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
32
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
33
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
34
Epirubicin Approved Phase 2 56420-45-2 41867
35
Lenograstim Approved Phase 2 135968-09-1
36 Protective Agents Phase 2
37 Antiemetics Phase 2
38 Antifungal Agents Phase 2
39 Anti-Infective Agents Phase 2
40 Autonomic Agents Phase 2
41 Calcineurin Inhibitors Phase 2
42 Cyclosporins Phase 2
43 Dermatologic Agents Phase 2
44 Gastrointestinal Agents Phase 2
45 Methylprednisolone acetate Phase 2
46 Methylprednisolone Hemisuccinate Phase 2
47 Muromonab-CD3 Phase 2
48 Neuroprotective Agents Phase 2
49 Peripheral Nervous System Agents Phase 2
50 Prednisolone acetate Phase 2

Interventional clinical trials:

(show top 50) (show all 58)

id Name Status NCT ID Phase Drugs
1 RHYTHM (Formerly Escape II Myocardium) Recruiting NCT01548768 Phase 4 TNF inhibitors;DMARDs
2 CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial) Unknown status NCT01877746 Phase 3 Combination of prednisone and azathioprine;Combination of prednisone and azathioprine
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
5 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
6 COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF Not yet recruiting NCT02582190 Phase 3 Colchicine group
7 IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN Unknown status NCT01995799 Phase 2
8 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
9 Myocarditis Treatment Trial Completed NCT00000524 Phase 2 cyclosporine;prednisone
10 Late Cardiac Evaluation of the Three Arm Belgian Trial Involving Node-positive Early Breast Cancer Patients Completed NCT01554943 Phase 2
11 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
12 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Recruiting NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
13 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
14 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
15 Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy Completed NCT02028403 Phase 1 BMS-936559;Placebo for BMS-936559
16 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
17 International Myocarditis Registry Unknown status NCT01307735
18 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
19 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients Unknown status NCT01089036
20 2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis Unknown status NCT01092429
21 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
22 Implementation of Work in Progress (WIP) Sequences in Magnetic Resonance Imaging (MRI) Unknown status NCT01019226
23 Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death Unknown status NCT01919983
24 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
25 Study of Muromonab-CD3 and Cyclosporine in Patients With Giant Cell Myocarditis Completed NCT00027443 Muromonab-CD3;Cyclosporine
26 CMR in Patients With Myocarditis Completed NCT01962584
27 Risk Factors for Predictors of In-hospital Death in Acute Fulminant Myocarditis Completed NCT03219996
28 Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis Completed NCT00693134
29 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531
30 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
31 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
32 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
33 Inflammatory Cardiomyopathy Baseline Cohort (SFB/TR19) Completed NCT02970227
34 Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection Completed NCT00426699
35 Clinical Assessment of New Treatment Regimen for Adult Fulminant Myocarditis Recruiting NCT03268642
36 Myocarditis Registry for Children and Adolescents - MYKKE Recruiting NCT02590341
37 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
38 Quantitative Cardiac Parametric Mapping (Myomapping) Recruiting NCT02855554
39 Cologne Register of Wearable Defibrillator (CRWD) Recruiting NCT02073942
40 Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects Recruiting NCT02874703
41 Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study) Recruiting NCT02740179 Eplerenone;Placebo
42 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRI Recruiting NCT02318498
43 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
44 Follow-up of the Cardiomyopathy Cohort SFB/TR19 Recruiting NCT02971267
45 German Centre for Cardiovascular Research Cardiomyopathy Register Recruiting NCT02187263
46 Multicenter Cohort of STEMI Patients Recruiting NCT03070496
47 Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis Recruiting NCT02655718
48 Post-Pregnancy Cardio Trial Recruiting NCT03313063
49 Magnetic Resonance Imaging in Myocarditis Active, not recruiting NCT02177630
50 ACAM2000® Myopericarditis Registry Active, not recruiting NCT01395082

Search NIH Clinical Center for Myocarditis

Cochrane evidence based reviews: myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

MalaCards organs/tissues related to Myocarditis:

39
Heart, T Cells, Liver, Monocytes, Breast, Tonsil, B Cells

Publications for Myocarditis

Articles related to Myocarditis:

(show top 50) (show all 1922)
id Title Authors Year
1
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
2
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. ( 28931401 )
2017
3
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis. ( 28359509 )
2017
4
Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation. ( 28772040 )
2017
5
Regulation of autoimmune myocarditis by host responses to the microbiome. ( 28822770 )
2017
6
A Pitfall in the Diagnosis of Eosinophilic Myocarditis in a Patient who Received Steroid Therapy. ( 28090045 )
2017
7
Eosinophilic myocarditis and hypereosinophilic syndrome. ( 28652675 )
2017
8
A fulminant case of idiopathic giant cell myocarditis. ( 28745125 )
2017
9
Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis. ( 28576783 )
2017
10
Giant cell myocarditis presenting with acute heart failure. ( 28536222 )
2017
11
Sudden death and acute myocarditis: a unique forensic case of double origin of coronary arteries. ( 28928257 )
2017
12
Immunosuppressive treatment in fulminant myocarditis and gene expression pattern associated with, but no histological confirmation of giant cell myocarditis. ( 28451456 )
2017
13
Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. ( 28772042 )
2017
14
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
15
Granulomatosis with Polyangiitis with Myocarditis and Ventricular Tachycardia. ( 28912820 )
2017
16
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
17
Acute myocarditis secondary to cardiac tuberculosis: a case report. ( 28814447 )
2017
18
Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. ( 28485792 )
2017
19
Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis. ( 28902285 )
2017
20
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
21
Established and novel treatment options in acute myocarditis, with or without heart failure. ( 27858465 )
2017
22
Increased Mobilization of CD45+CD34+VLA-4+ Cells in Acute Viral Myocarditis Induced by Coxsackievirus B3. ( 28866672 )
2017
23
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis. ( 28887702 )
2017
24
Oleuropein prevents the development of experimental autoimmune myocarditis in rats. ( 28525856 )
2017
25
Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. ( 28440472 )
2017
26
Noninvasive Imaging of Myocardial Inflammation in Myocarditis using (68)Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography. ( 28042344 )
2017
27
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
28
Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. ( 28757189 )
2017
29
Third-Degree Atrioventricular Block and Collapse Associated with Eosinophilic Myocarditis in a Horse. ( 28295606 )
2017
30
Ferumoxytol in acute myocarditis: 'keep your head in the clouds and your feet on the earth'. ( 28780574 )
2017
31
Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. ( 28584814 )
2017
32
The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. ( 28618428 )
2017
33
Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients. ( 28042125 )
2017
34
TRAF6: A player in CVB3-induced myocarditis? ( 28886971 )
2017
35
Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8a88mg/kg/d) of anakinra. ( 28614216 )
2017
36
Parvovirus B19 Myocarditis of Fulminant Evolution. ( 28868104 )
2017
37
Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan. ( 28821685 )
2017
38
Treatment of Fulminant Giant Cell Myocarditis Associated with Polymyositis Using a Left Ventricular Assist Device and Subsequent Corticosteroid and Immunosuppressive Therapy Leading to Remission. ( 28781324 )
2017
39
Epsilon wave on an electronic loop in a case of Arrhythmogenic Right Ventricular Dysplasia with myocarditis: an updated definition of the Epsilon wave. ( 28062531 )
2017
40
NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis. ( 28912259 )
2017
41
A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis. ( 27878326 )
2017
42
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
43
Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema. ( 28500369 )
2017
44
Pathogenesis of coxsackievirus B2 in mice: characterisation of clinical isolates of the coxsackievirus B2 from patients with myocarditis and aseptic meningitis in Korea. ( 28384999 )
2017
45
FGL2 deteriorates cardiac function in experimental autoimmune myocarditis rats through regulation of PD-1 and inflammatory cytokines. ( 28892130 )
2017
46
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. ( 28410530 )
2017
47
A Complex Heart Team's Approach to a Patient With Giant Cell Myocarditis. ( 28822649 )
2017
48
Viral Nucleic Acids in the Serum Are Dependent on Blood Sampling Site in Patients with Clinical Suspicion of Myocarditis. ( 28081531 )
2017
49
Feline Panleukopenia Virus Is Not Associated With Myocarditis or Endomyocardial Restrictive Cardiomyopathy in Cats. ( 28622497 )
2017
50
Clinical and magnetic resonance evolution of "infarct-like" myocarditis. ( 28070840 )
2017

Variations for Myocarditis

Expression for Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for Myocarditis

Pathways related to Myocarditis according to KEGG:

37
id Name Kegg Source Accession
1 Viral myocarditis hsa05416

Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 36)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD40 CD40LG CD55 CD86 CXADR DSP
2
Show member pathways
13.4 CD40 CD40LG CD86 CXADR HLA-B HLA-DQB1
3
Show member pathways
13.24 CD40 CD40LG CD86 HLA-B HLA-DQB1 ICAM1
4
Show member pathways
12.54 CD40 CD40LG CD86 HLA-DQB1 IL12RB1 TNF
5
Show member pathways
12.37 DAG1 DMD DSP ITGB2
6
Show member pathways
12.34 CD40 CD40LG CD86 HLA-DQB1
7 12.34 CD40 HLA-B HLA-DQB1 ICAM1 ITGB2 TNF
8
Show member pathways
12.29 ICAM1 ITGB2 MYH6 NOS2
9 12.24 CD40 HLA-B HLA-DQB1 ICAM1
10
Show member pathways
12.18 CD40 CD40LG CD55 CD86 CXADR DAG1
11 12.16 HLA-DQB1 ITGB2 NOS2 TNF
12
Show member pathways
12.12 CD40 CD40LG HLA-DQB1 ITGB2 NOS2 TNF
13 11.93 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
14 11.91 ICAM1 ITGB2 NOS2 TNF
15 11.88 CXADR DSP ICAM1 ITGB2
16 11.86 CD40 CD40LG CD86 HLA-B HLA-DQB1 ICAM1
17 11.83 CD55 HLA-DQB1 TNF
18 11.82 ITGB2 NOS2 TNF
19 11.8 CD40 CD40LG ICAM1 TNF
20
Show member pathways
11.76 CD40 CD40LG TNF
21 11.76 CD86 HLA-DQB1 ICAM1 ITGB2 TNF
22 11.71 ITGB2 NOS2 TNF
23
Show member pathways
11.68 CD40 CD40LG TNF
24 11.67 DMD MYH6 TNNI3
25
Show member pathways
11.6 CD40LG ICAM1 NOS2 TNF
26 11.56 CD40 CD40LG CD86
27 11.54 HLA-DQB1 ICAM1 ITGB2
28 11.5 CD40 CD40LG CD86
29 11.46 CD86 ICAM1 TNF
30 11.44 ICAM1 ITGB2 TNF
31 11.43 ITGB2 NOS2 TNF
32 11.34 CD40 CD40LG ICAM1 ITGB2 TNF
33 11.31 HLA-B ICAM1 NOS2
34 11.28 CD40 CD40LG ICAM1 ITGB2 NOS2 TNF
35 11.25 CD40 CD40LG CD86
36 10.53 MB NOS2

GO Terms for Myocarditis

Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.63 CD55 CXADR DAG1 DMD ICAM1 TNF
2 cell surface GO:0009986 9.61 CD40 CD40LG CD55 CD86 DMD HLA-B
3 filopodium GO:0030175 9.58 CXADR DAG1 DMD
4 ficolin-1-rich granule membrane GO:0101003 9.54 CD55 DSP ITGB2
5 myofibril GO:0030016 9.5 DMD MYH6 TNNI3
6 external side of plasma membrane GO:0009897 9.17 CD40 CD40LG CD86 DAG1 ICAM1 IL12RB1
7 extracellular exosome GO:0070062 10.13 CD40 CD55 CD86 DAG1 DSP HLA-B
8 plasma membrane GO:0005886 10.1 CD40 CD40LG CD55 CD86 CXADR DAG1

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.93 CD40 CD40LG CD86 HLA-B HLA-DQB1 TNF
2 leukocyte migration GO:0050900 9.91 CXADR ICAM1 ITGB2 TNF
3 extracellular matrix organization GO:0030198 9.89 DAG1 ICAM1 ITGB2 TNF
4 inflammatory response GO:0006954 9.88 CD40 CD40LG ITGB2 TNF
5 viral process GO:0016032 9.88 CD55 CD86 CXADR DAG1 HLA-B ICAM1
6 aging GO:0007568 9.87 CD86 DAG1 DMD ITGB2
7 T cell costimulation GO:0031295 9.8 CD40LG CD86 HLA-DQB1
8 heart development GO:0007507 9.79 CXADR MB TNNI3
9 interferon-gamma-mediated signaling pathway GO:0060333 9.79 HLA-B HLA-DQB1 ICAM1
10 cellular response to interferon-gamma GO:0071346 9.76 ICAM1 IL12RB1 NOS2
11 response to hypoxia GO:0001666 9.72 ICAM1 MB NOS2
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40 CD40LG ICAM1 ITGB2 TNF
13 cardiac muscle contraction GO:0060048 9.7 DMD MYH6 TNNI3
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 ICAM1 ITGB2 TNF
15 response to lipopolysaccharide GO:0032496 9.67 CD40 CD86 ICAM1 NOS2
16 muscle filament sliding GO:0030049 9.65 DMD MYH6 TNNI3
17 cellular response to lipopolysaccharide GO:0071222 9.65 CD40 CD86 ICAM1 NOS2 TNF
18 cellular response to mechanical stimulus GO:0071260 9.63 CD40 DAG1
19 regulation of immune response GO:0050776 9.63 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
20 response to denervation involved in regulation of muscle adaptation GO:0014894 9.62 DAG1 DMD
21 leukocyte cell-cell adhesion GO:0007159 9.61 CD40LG ICAM1 ITGB2
22 cardiac muscle fiber development GO:0048739 9.6 CXADR MYH6
23 response to peptide hormone GO:0043434 9.56 CD55 DAG1
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 ICAM1 TNF
25 cellular extravasation GO:0045123 9.49 ITGB2 TNF
26 regulation of immunoglobulin secretion GO:0051023 9.13 CD40 CD40LG TNF
27 viral entry into host cell GO:0046718 9.02 CD55 CD86 CXADR DAG1 ICAM1

Molecular functions related to Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.56 CD40 CD86 ICAM1 ITGB2
2 vinculin binding GO:0017166 9.37 DAG1 DMD
3 dystroglycan binding GO:0002162 9.16 DAG1 DMD
4 cell adhesion molecule binding GO:0050839 9.13 CXADR DSP ITGB2
5 virus receptor activity GO:0001618 9.02 CD55 CD86 CXADR DAG1 ICAM1
6 protein binding GO:0005515 10.22 CD40 CD40LG CD55 CD86 CXADR DAG1

Sources for Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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