MCID: MYC008
MIFTS: 50

Myocarditis malady

Rare diseases, Cardiovascular diseases categories

Aliases & Classifications for Myocarditis

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Summaries for Myocarditis

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Wikipedia:64 Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle. The consequences of... more...

MalaCards based summary: Myocarditis, also known as myocardial inflammation, is related to acute myocarditis and dilated cardiomyopathy. An important gene associated with Myocarditis is IL12RB1 (interleukin 12 receptor, beta 1), and among its related pathways are Type II interferon signaling (IFNG) and Primary immunodeficiency. The compounds toxin-1 and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Related Diseases for Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 282)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis32.3TXN, TNC
2dilated cardiomyopathy30.9CHKB, ADRB1, MYH6, TXN
3myocardial infarction30.8TNC, CIITA, ADRB1, CHKB
4acute myocardial infarction30.5TNC, TXN, ADRB1, CHKB
5ulcerative colitis30.4NOS2, IL12RB1, CHKB
6acute respiratory distress syndrome30.2NOS2, TXN
7common variable immunodeficiency30.1ICOS, IL2
8hepatitis b30.1TXN, CIITA, IL2
9congestive heart failure30.0TXN, ADRB1, CHKB
10arthritis30.0NOS2, CIITA, TXN
11coronary artery disease30.0TXN, ADRB1, CHKB
12atopic dermatitis29.9IL10RA, IL12RB1, IL2
13atrial fibrillation29.8ADRB1, CHKB
14ischemia29.7TNC, CIITA, CHKB, NOS2
15asthma29.6NOS2, IL12RB1, CHKB, CIITA, TNC
16systemic lupus erythematosus29.5CIITA, ADRB1, ICOS, IL2, IL12RB1, IL10RA
17melanoma28.7TNC, TXN, CIITA, CHKB, IL2, IL10RA
18autoimmune myocarditis11.1
19giant cell myocarditis11.0
20rheumatic myocarditis10.6
21interstitial myocarditis10.6
22fiedler's myocarditis10.6
23toxic myocarditis10.5
24infectious myocarditis10.5
25influenza10.5
26periapical granuloma10.5NOS2
27atrioventricular block10.4
28pericarditis10.4
29thymoma10.4
30myositis10.4
31cardiogenic shock10.4
32lupus erythematosus10.3
33diabetes mellitus, insulin-dependent10.3CIITA, NOS2
34pulmonary sarcoidosis10.3IL2, IL12RB1
35toxic shock syndrome10.3CIITA, IL2
36pneumonia10.3
37pleomorphic adenoma10.3TNC, NOS2
38pulmonary tuberculosis10.3IL2, IL12RB1
39churg-strauss syndrome10.3
40myopathy congenital10.3MYH6, CHKB
41cork-handlers' disease10.3TNC, TXN, IL12RB1
42sarcoidosis 110.3TXN, IL2, IL12RB1
43hepatitis10.3
44trichinosis10.3
45adult-onset still's disease10.3
46eosinophilia10.3
47polymyositis10.3
48lymphopenia10.2CIITA, IL2
49hepatitis c10.2TXN, CIITA, IL2
50myasthenia gravis10.2

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to myocarditis

Symptoms for Myocarditis

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Drugs & Therapeutics for Myocarditis

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Drug clinical trials:

Search ClinicalTrials for Myocarditis

Search NIH Clinical Center for Myocarditis

Genetic Tests for Myocarditis

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Anatomical Context for Myocarditis

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MalaCards organs/tissues related to Myocarditis:

31
Heart, T cells, Monocytes, Tonsil, Bone, Liver, B cells, Cardiac myocytes, Brain, Thyroid, Bone marrow, Thymus, Skeletal muscle, Adipocyte, Kidney, Lung, Pancreas, Skin, Testes, Myeloid, Nk cells, Endothelial

Animal Models for Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Myocarditis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4ADRB1, ICOS, IL2, NOS2, CIITA
2MP:00053868.1TNC, MYH6, CHKB, IL2, NOS2, CD274
3MP:00053977.4CIITA, ICOS, IL2, IL12RB1, IL10RA, NOS2
4MP:00053877.3CIITA, ICOS, IL2, IL12RB1, IL10RA, NOS2
5MP:00053766.4CD274, TNC, CIITA, MYH6, ADRB1, CHKB

Publications for Myocarditis

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Articles related to Myocarditis:

(show top 50)    (show all 1647)
idTitleAuthorsYear
1
Long-Term Risk of Recurrence, Morbidity and Mortality in Giant Cell Myocarditis. (25882774)
2015
2
Ultra-low dose comprehensive cardiac CT imaging in a patient with acute myocarditis. (25439792)
2014
3
Clinically manifested myocarditis in acute rheumatic fever. (24676379)
2014
4
A case of fetal parvovirus b19 myocarditis that caused terminal heart failure. (25328731)
2014
5
Formation of a fibrin net on the polypropylene membrane oxygenator used for percutaneous cardiopulmonary support in a patient with acute myocarditis. (24875892)
2014
6
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
7
Enteroviral myocarditis in neonates. (23711335)
2013
8
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
9
Thrombotic events in critically ill children with myocarditis. (24016733)
2013
10
Pericarditis, myocarditis, and other cardiomyopathies. (23402470)
2013
11
Fulminant human herpesvirus 6 myocarditis in an immunocompetent adult: role of cardiac magnetic resonance in a multidisciplinary approach. (24297820)
2013
12
Myocarditis: early biopsy allows for tailored regenerative treatment. (22685492)
2012
13
A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-I_B signaling. (23029542)
2012
14
Endocarditis and myocarditis: a brief review. (23098151)
2012
15
Autoimmunity against Ma88muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. (22328321)
2012
16
Pathogenesis of coxsackievirus B3-induced myocarditis: role of macrophage migration inhibitory factor. (22340465)
2012
17
PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis. (20356766)
2011
18
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
19
Dengue myositis and myocarditis. (20739801)
2010
20
Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis. (18329552)
2008
21
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
22
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
23
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
24
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
25
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
26
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome. (15837284)
2005
27
An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. (14613869)
2003
28
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
29
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
30
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
31
Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice. (9166288)
1997
32
Data on giant cell myocarditis sought for new study. (8616928)
1996
33
Announcement of multicenter giant-cell myocarditis study. (7677103)
1995
34
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
35
Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. (2396870)
1990
36
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
37
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
38
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
39
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
40
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985
41
A case of congestive cardiomyopathy with histological findings suggesting rheumatic myocarditis by endomyocardial biopsy. (6448932)
1980
42
Giant cell myocarditis. (6989338)
1980
43
A case of giant cell myocarditis. (4748147)
1973
44
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
45
Rheumatic myocarditis in an infant nine months of age. (5782817)
1969
46
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
47
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
48
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
49
Fiedler's myocarditis at age of two months. (13217368)
1954
50
Fulminating trichinosis with myocarditis. (13176789)
1954

Variations for Myocarditis

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Expression for genes affiliated with Myocarditis

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Search GEO for disease gene expression data for Myocarditis.

Pathways for genes affiliated with Myocarditis

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Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS2, CIITA
29.8ICOS, CIITA
39.8NOS2, IL2
4
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.6NOS2, IL12RB1, IL2
5
Show member pathways
Type III interferon signaling36
9.5IL2, IL12RB1, IL10RA
69.5NOS2, IL10RA, CIITA
7
Show member pathways
9.2MYH6, IL2, IL12RB1, IL10RA
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.1IL2, IL12RB1, IL10RA, NOS2
99.0IL2, CIITA, TXN
10
Show member pathways
8.9IL2, IL12RB1, IL10RA, CD70
11
Show member pathways
8.9TNC, MYH6, IL2, IL12RB1, IL10RA
12
Show member pathways
8.9CIITA, IL2, IL12RB1, IL10RA, NOS2
13
Show member pathways
8.5IL10RA, IL12RB1, IL2, ICOS, MYH6, CIITA

Compounds for genes affiliated with Myocarditis

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Compounds related to Myocarditis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1toxin-14410.2CIITA, IL2
2glatiramer acetate44 1111.2CIITA, IL2
3taurine chloramine4410.2NOS2, IL2
4il-124410.2IL2, IL12RB1
5minocycline44 1111.2CIITA, NOS2
6nebivolol44 1111.1ADRB1, NOS2
7triptolide4410.0NOS2, IL2
8polyinosinic-polycytidylic acid4410.0NOS2, CIITA, IL2
9xamoterol44 2810.8ADRB1, CHKB
10dobutamine44 28 50 1112.8CHKB, ADRB1
11isoproterenol44 1110.7ADRB1, MYH6, NOS2
12fotemustine44 1110.7TXN, IL2
13ebselen449.7NOS2, TXN
14gold sodium thiomalate449.7IL2, TXN
15rosuvastatin44 50 28 1112.6NOS2, CHKB
16amiodarone44 50 28 1112.6ADRB1, CHKB
17auranofin28 44 60 1112.6TXN, IL2
18guanidine44 24 1111.6NOS2, CHKB
19endotoxin449.6CHKB, NOS2, CIITA
20rantes449.5CIITA, IL2, CD70
21triiodothyronine449.5MYH6, ADRB1, CHKB
22salbutamol44 50 28 24 1113.4CHKB, ADRB1
23chloramphenicol44 1 50 1112.3TXN, MYH6, TNC
24pge2449.3NOS2, CHKB, IL2, CIITA
25ionomycin449.3IL12RB1, CD274, CD70, IL2
26gssg449.2TXN, CHKB
27cerivastatin50 44 28 1112.2CHKB, NOS2
28gsno449.2NOS2, TXN
29carnitine449.2TXN, CHKB, MYH6
30isotretinoin44 1110.1TXN, CHKB, IL2
31peroxynitrite449.1TXN, CHKB, NOS2
32thyroxine44 249.9TXN, CIITA, CHKB, MYH6
33n acetylcysteine448.9NOS2, CHKB, TXN
34actinomycin d448.9TNC, TXN, IL2, NOS2, CIITA
35ascorbic acid44 249.8CHKB, TXN, TNC, NOS2
36cycloheximide448.8IL2, NOS2, CIITA, TXN, TNC
37tyrosine448.8IL10RA, IL12RB1, IL2, ADRB1, TNC, CIITA
38cyclosporin a44 28 6010.8IL2, CIITA, TXN, CHKB
39h2o2448.7NOS2, TNC, CHKB, TXN
40nitric oxide44 24 1110.7CD274, NOS2, CIITA, ADRB1, CHKB
41adenylate448.6TXN, ADRB1, CHKB, NOS2
42estrogen448.5TNC, TXN, MYH6, NOS2, CHKB
43calcium44 50 24 1111.5CHKB, ADRB1, MYH6, NOS2, TNC, CIITA
44vegf448.5NOS2, TNC, TXN, IL2, CHKB
45arginine448.4ADRB1, MYH6, TXN, CHKB, NOS2
46glutamate448.4TXN, NOS2, CHKB, TNC, ADRB1
47alanine448.3TXN, CIITA, ADRB1, CHKB
48oxygen44 249.1TXN, CHKB, ADRB1, CIITA, MYH6, NOS2
49serine448.0TNC, IL10RA, IL2, ADRB1, TXN, MYH6
50dexamethasone44 50 28 1110.0IL2, CD274, NOS2, IL12RB1, CHKB, ADRB1

GO Terms for genes affiliated with Myocarditis

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Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3CD274, IL12RB1, ICOS

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:00421049.9IL2, IL12RB1
2cellular response to interferon-gammaGO:00713469.9NOS2, IL12RB1
3positive regulation of interferon-gamma productionGO:00327299.9IL12RB1, IL2
4cytokine-mediated signaling pathwayGO:00192219.4CIITA, IL12RB1, IL10RA
5immune responseGO:00069558.6CD70, CD274, IL2, ICOS, CIITA
6cell-cell signalingGO:00072678.5CD70, IL2, TXN
7signal transductionGO:00071658.1TXN, IL12RB1, IL10RA, CD274, CD70

Sources for Myocarditis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet