MCID: MYC008
MIFTS: 56

Myocarditis malady

Summaries for Myocarditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle (myocardium). more...

MalaCards: Myocarditis, also known as myocarditis, unspecified, is related to acute myocarditis and dilated cardiomyopathy. An important gene associated with Myocarditis is MYH6 (myosin, heavy chain 6, cardiac muscle, alpha), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Myocarditis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

myocarditis 8 42 10 44 60
myocarditis, unspecified 8
myocardial inflammation 8
myocarditis nos 8


External Ids:

Disease Ontology8 DOID:820
ICD9CM27 429.0
NCIt39 C34831
MeSH34 D009205

Related Diseases for Myocarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis31.7TNC, TXN
2dilated cardiomyopathy30.9TXN, MYH6, CXADR
3myocardial infarction30.9TNC, CIITA, PTX3
4acute myocardial infarction30.8TXN, TNC, PTX3
5influenza30.6CIITA, TNFSF9, TXN
6lupus erythematosus30.4CD70
7systemic lupus erythematosus30.4LCN2, ICOS, CIITA, CD70, IL10RA, IL12RB1
8sarcoidosis30.3IL2, IL12RB1, TXN
9encephalitis30.1NOS2, CD68, CIITA
10arthritis30.0NOS2, CXCL2, CIITA, TXN
11celiac disease30.0CIITA
12leukemia29.9CXADR, CXCL2, IL2
13thyroiditis29.9CIITA
14severe combined immunodeficiency29.9IL2, CIITA
15melanoma29.6TXN, TNC, CIITA, CD68, CD274, CD70
16multiple sclerosis29.6TNC, TNFSF9, CIITA, CD274, IL2, NOS2
17asthma29.6NOS2, IL12RB1, CIITA, TNC, LCN2
18ischemia29.6LCN2, TNC, CIITA, CXCL2, NOS2
19tuberculosis29.6CIITA, IL12RB1, IL2
20hepatitis b29.6IL2, CIITA, TXN
21adenocarcinoma29.6LCN2, TNC, CXADR, IL10RA, NOS2
22vasculitis29.6PTX3, LCN2
23peritonitis29.6CXCL2
24wegener's granulomatosis29.6CIITA
25congenital heart defect29.6TXN, MYH6, CXADR
26diabetes mellitus29.6TXN
27rheumatic myocarditis10.5
28interstitial myocarditis10.5
29fiedler's myocarditis10.5
30toxic myocarditis10.5
31atrioventricular block10.4
32pericarditis10.3
33thymoma10.3
34myositis10.3
35pneumonia10.2
36giant cell myocarditis10.2
37churg-strauss syndrome10.2
38infectious myocarditis10.2
39trichinosis10.2
40cardiac tamponade10.2
41septic myocarditis10.2
42eosinophilia10.2
43hepatitis10.2
44myasthenia gravis10.2
45diphtheria10.1
46arrhythmogenic right ventricular dysplasia10.1
47ulcerative colitis10.1
48hypertrophic cardiomyopathy10.1
49tonsillitis10.1
50kawasaki disease10.1

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to myocarditis

Clinical Features for Myocarditis

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Drugs & Therapeutics for Myocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myocarditis

Drug clinical trials:

Search ClinicalTrials for Myocarditis

Search NIH Clinical Center for Myocarditis

Search CenterWatch for Myocarditis

Genetic Tests for Myocarditis

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Anatomical Context for Myocarditis

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32MalaCards
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MalaCards organs/tissues related to Myocarditis:

32
Heart, T cells, Monocytes, Tonsil, Bone, B cells, Liver, Cardiac myocytes, Thyroid, Brain, Pancreas, Endothelial, Thymus, Nk cells, Skeletal muscle, Kidney, Testes, Skin, Lung, Bone marrow

Animal Models for Myocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.4PTX3, LCN2, ICOS, TNFRSF9, TNFSF9, CIITA
2MP:000539711.2CD68, CIITA, TNFRSF9, ICOS, LCN2, CD274
3MP:000538411.0TXN, LCN2, ICOS, TNFRSF9, CIITA, CD274
4MP:000537610.9CIITA, TNC, ICOS, LCN2, MYH6, CD274
5MP:000537910.7PTX3, IL2, CXADR, CIITA

Publications for Myocarditis

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50PubMed
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Articles related to Myocarditis:

(show top 50)    (show all 1555)
idTitleAuthorsYear
1
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
2
Myocarditis, hepatitis, and pancreatitis in a patient with coxsackievirus A4 infection: a case report. (24410962)
2014
3
Advances in monoclonal antibody application in myocarditis. (23897786)
2013
4
The effects of gender and age on occurrence of clinically suspected myocarditis in adulthood. (24064227)
2013
5
Giant cell myocarditis associated with amoxicillin hypersensitivity reaction. (23504202)
2013
6
The periodontal pathogen aggregatibacter actinomycetemcomitans affects experimental autoimmune myocarditis in mice. (24309453)
2013
7
Eosinophilic myocarditis in an adolescent: a case report and review of the literature. (22995363)
2013
8
Presence of the viral genome in the myocardial tissue of patients without clinical suspicion of myocarditis. (22857786)
2013
9
Visualization of immune cell infiltration in experimental viral myocarditis by (19)F MRI in vivo. (23824166)
2013
10
Electrocardiographic findings and myocardial damage in acute myocarditis detected by cardiac magnetic resonance. (22388951)
2012
11
Cellular immune mechanisms in myocarditis. (23179049)
2012
12
Recurrent congestive heart failure in a child due to probable myocarditis. (21910020)
2012
13
Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by experimental autoimmune myocarditis. (21383952)
2011
14
Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. (20378858)
2010
15
Innate immune receptor activation in viral myocarditis: pathophysiologic implications. (20391900)
2010
16
Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis. (18608177)
2009
17
Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study. (19710029)
2009
18
Dengue hemorrhagic fever complicated with encephalopathy and myocarditis: a case report. (19245163)
2008
19
Genetic complexity of autoimmune myocarditis. (18190873)
2008
20
Acute myocarditis with normal systolic wall thickening: inside physiopathological mechanisms and diagnostic imaging techniques. (17570543)
2008
21
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
22
Orthotopic cardiac transplantation for the treatment of progressive heart failure caused by idiopathic giant cell myocarditis. (16844247)
2007
23
A case of acute myocarditis with evaluation of magnetic resonance imaging. (16847738)
2007
24
Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats. (17042978)
2006
25
Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. (16710898)
2006
26
Acute heart failure due to fulminant and giant cell myocarditis. (17149678)
2006
27
Unusual ventilation-perfusion scintigraphy in adult respiratory distress syndrome secondary to acute lupus myocarditis. (15545896)
2004
28
Thioredoxin-1 ameliorates myosin-induced autoimmune myocarditis by suppressing chemokine expressions and leukocyte chemotaxis in mice. (15337697)
2004
29
Prevention of myosin-induced autoimmune myocarditis in mice by anti-L3T4 monoclonal antibody. (12710519)
2003
30
Acute fatal toxic myocarditis after black widow spider envenomation. (12526131)
2003
31
Captopril prevents experimental autoimmune myocarditis. (12817017)
2003
32
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression. (12123771)
2002
33
Bullous pemphigoid associated with acute myocarditis. (11937752)
2002
34
Innovative drug treatments for viral and autoimmune myocarditis. (12028603)
2002
35
Identification and characterization of the antigen presenting cell in rat autoimmune myocarditis: evidence of bone marrow derivation and non-requirement for MHC class I compatibility with pathogenic T cells. (11040077)
2000
36
Neonatal lupus erythematosus with congenital heart block and severe heart failure due to myocarditis and endocardititis of the mitral valve. (8796403)
1996
37
Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus. (8549201)
1996
38
Fatal giant cell myocarditis after resection of thymoma. (8665352)
1996
39
Giant Cell Myocarditis Study Group. (7484795)
1995
40
Giant cell myocarditis: monocytic immunophenotype of giant cells in a case associated with ulcerative colitis. (7821909)
1995
41
Treatment of serious heart failure by transplantation in giant cell myocarditis diagnosed by endomyocardial biopsy. (8061033)
1994
42
Experimentally-induced autoimmune myocarditis: production of heart myosin-specific autoantibodies within the inflammatory infiltrate. (1932515)
1991
43
Toxic myocarditis in paracetamol poisoning. (3120894)
1987
44
Fatal giant cell myocarditis after colectomy for ulcerative colitis. (3716997)
1986
45
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
46
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985
47
Fiedler's myocarditis and heart block with scar tissue injury of septal nerves. (4382880)
1967
48
A case of interstitial myocarditis]. (13527020)
1957
49
Diagnosis and treatment of acute interstitial myocarditis in infancy. (13207923)
1954
50
Diffuse interstitial myocarditis in children. (18894824)
1948

Genetic Variations for Myocarditis

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Expression for genes affiliated with Myocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocarditis

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Pathways for genes affiliated with Myocarditis

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51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Myocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0TNC, TNFRSF9, TNFSF9, MYH6, CXCL2, IL10RA
2
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10.9TNFRSF9, TNFSF9, CD70, CXCL2, IL10RA, IL12RB1
3
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10.9IL12RB1, IL10RA, CXADR, MYH6, CIITA, ICOS
4
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10.8TNFRSF9, TNFSF9, MYH6, CXCL2, IL10RA, IL12RB1
5
Hide members
10.8TNFRSF9, TNFSF9, CXCL2, IL10RA, IL12RB1, IL2
6
Hide members
10.8TXN, ICOS, CIITA, CD274, CXADR, IL2
7
Hide members
10.8CIITA, IL10RA, IL12RB1, IL2, NOS2
8
Development PDGF signaling via STATs and NF-kB
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10.7IL10RA, IL12RB1, IL2, NOS2
910.7NOS2, IL2, CXCL2

Compounds for genes affiliated with Myocarditis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Myocarditis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.4LCN2, TNC, TNFRSF9, CIITA, CXADR, CXCL2
2nitric oxide44 11 2413.2LCN2, CIITA, CD274, CXADR, CXCL2, NOS2
3dexamethasone44 49 28 1114.2PTX3, TXN, TNFRSF9, CIITA, CXADR, CXCL2
4actinomycin d4411.1TXN, TNC, CIITA, IL2, NOS2, PTX3
5ionomycin4411.1TNFRSF9, CD274, CD70, IL12RB1, IL2
6serine4411.1TXN, CIITA, MYH6, CXADR, CXCL2
7oxygen44 2412.0TXN, LCN2, CIITA, MYH6, CXCL2, NOS2
8estrogen4410.9TXN, LCN2, TNC, MYH6, CXCL2, NOS2
9polyinosinic-polycytidylic acid4410.9CIITA, IL2, NOS2
10ccl344 2811.9PTX3, CXCL2, TNFRSF9
11rantes4410.9CIITA, CXCL2, IL2
12neomycin4410.8IL2, CXADR, MYH6
13fotemustine44 1111.8IL2, TXN
14taurine chloramine4410.6NOS2, IL2
15glatiramer acetate44 1111.6IL2, CIITA
16toxin-14410.5CIITA, IL2
17gold sodium thiomalate4410.3IL2, TXN

GO Terms for genes affiliated with Myocarditis

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16Gene Ontology
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Cellular components related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9IL2, LCN2, TNC, TNFRSF9, TNFSF9, CD70
2external side of plasma membraneGO:00989710.7IL12RB1, CD274, TNFRSF9, ICOS
3extracellular regionGO:00557610.7TXN, LCN2, ICOS, TNC, CXADR, CXCL2

Biological processes related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.0IL2, ICOS, TNFSF9, CIITA, CD274, CD70
2signal transductionGO:00716510.7TXN, TNFSF9, CD274, CD70, IL10RA, IL12RB1
3cell-cell signalingGO:00726710.7TXN, TNFSF9, CD70, IL2
4cardiac muscle fiber developmentGO:04873910.7CXADR, MYH6
5positive regulation of activated T cell proliferationGO:04210410.6IL2, IL12RB1
6protein homotrimerizationGO:07020710.3TNFRSF9, LCN2

Molecular functions related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.7NOS2, CXADR, CD70, TNFSF9

Products for genes affiliated with Myocarditis

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Sources for Myocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet