MCID: MYC008
MIFTS: 58

Myocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Myocarditis

Summaries for Myocarditis

NIH Rare Diseases : 49 Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak. Last updated: 3/15/2016

MalaCards based summary : Myocarditis, also known as myocardial inflammation, is related to giant cell myocarditis and acute myocarditis. An important gene associated with Myocarditis is DMD (Dystrophin), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Methotrexate and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Wikipedia : 72 Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms... more...

Related Diseases for Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 giant cell myocarditis 34.2 HLA-B MB
2 acute myocarditis 33.8 CD40 CD86 TNNI3
3 chagas disease 31.8 NOS2 NPPB TNF
4 plasmodium vivax malaria 30.1 CD40LG ICAM1 TNF
5 vasculitis 29.9 CD40LG ICAM1 TNF
6 neuronitis 29.8 CD40LG MB
7 systemic lupus erythematosus 29.8 CD40 CD40LG CD86 HLA-DQB1 ICAM1 TNF
8 rubella 29.8 CD40LG HLA-B TNF
9 idiopathic inflammatory myopathy 29.8 HLA-B HLA-DQB1
10 autoimmune disease 29.8 CD40 CD40LG HLA-B HLA-DQB1 TNF
11 erythema multiforme 29.7 DSP ICAM1 TNF
12 acquired immunodeficiency syndrome 29.7 CD40LG HLA-B TNF
13 chlamydia 29.7 CD40LG NOS2 TNF
14 common variable immunodeficiency 29.6 CD40 CD40LG CD86 TNF
15 pulmonary edema 29.6 ICAM1 NPPB TNF
16 myocardial infarction 29.5 CD40LG ICAM1 MB NPPB TNF TNNI3
17 atrial standstill 1 29.5 DMD DSP NPPB TNNI3
18 malaria 29.2 CD40 CD40LG CD55 HLA-B ICAM1 NOS2
19 multiple sclerosis 29.0 CD40 CD86 HLA-DQB1 ICAM1 NOS2 TNF
20 hypertrophic cardiomyopathy 29.0 MYH6 NPPB TNF TNNI3
21 arteries, anomalies of 28.6 ICAM1 MB NPPB TNF TNNI3
22 heart disease 28.5 DSP MYH6 NPPB TNF TNNI3
23 dilated cardiomyopathy 27.8 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
24 autoimmune myocarditis 12.3
25 rheumatic myocarditis 12.3
26 fiedler's myocarditis 12.2
27 septic myocarditis 12.1
28 interstitial myocarditis 12.1
29 toxic myocarditis 12.1
30 infectious myocarditis 12.0
31 post-infectious myocarditis 11.8
32 trichinosis 11.4
33 diphtheria 11.4
34 odontoma-dysphagia syndrome 10.9
35 spondylometaphyseal dysplasia, sedaghatian type 10.9
36 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.8
37 light fixation seizure syndrome 10.6 CD40 CD40LG
38 annular erythema 10.5 ICAM1 ITGB2
39 heterophyiasis 10.5 CD40LG ICAM1
40 immunodeficiency with hyper-igm, type 4 10.5 CD40 CD40LG
41 penicilliosis 10.5 CD40 CD86 TNF
42 beryllium disease 10.5 HLA-DQB1 TNF
43 exanthema subitum 10.5 CD40 CD40LG CD86
44 lichen disease 10.5 CD40LG ICAM1 TNF
45 critical illness polyneuropathy 10.5 CD40LG ICAM1 TNF
46 cutaneous lupus erythematosus 10.5 CD40LG ICAM1 TNF
47 microscopic polyangiitis 10.5 HLA-B TNF
48 parasitic protozoa infectious disease 10.4 CD40LG ICAM1 TNF
49 autoimmune disease of central nervous system 10.4 CD40LG CD86
50 guillain-barre syndrome 10.4 CD40LG HLA-DQB1 TNF

Comorbidity relations with Myocarditis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Myocardial Ischemia
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to Myocarditis

Symptoms & Phenotypes for Myocarditis

GenomeRNAi Phenotypes related to Myocarditis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CD40LG DAG1 HLA-DQB1 ICAM1 NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CD40 CD40LG DAG1 HLA-DQB1 ICAM1 NOS2

MGI Mouse Phenotypes related to Myocarditis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 DAG1 CD40LG DMD DSP CXADR HLA-DQB1
2 cellular MP:0005384 10.25 CXADR HLA-DQB1 DAG1 CD40LG DMD CD86
3 behavior/neurological MP:0005386 10.22 CXADR DAG1 CD55 DMD CD86 TNF
4 hematopoietic system MP:0005397 10.18 HLA-DQB1 CD40 CD40LG DMD CD55 CD86
5 homeostasis/metabolism MP:0005376 10.17 CXADR CD40 DAG1 CD40LG DMD CD86
6 immune system MP:0005387 10.07 HLA-DQB1 CD40 CD40LG DMD CD55 CD86
7 endocrine/exocrine gland MP:0005379 10.06 CXADR CD40 CD40LG DMD CD86 HLA-DQB1
8 mortality/aging MP:0010768 10 CXADR DAG1 CD40LG DMD DSP TNF
9 muscle MP:0005369 9.73 DAG1 DMD CD86 DSP CXADR HLA-DQB1
10 respiratory system MP:0005388 9.23 CXADR DMD TNF MB HLA-DQB1 MYH6

Drugs & Therapeutics for Myocarditis

Drugs for Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
2
Adalimumab Approved Phase 4 331731-18-1 16219006
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Infliximab Approved Phase 4 170277-31-3
5
Certolizumab pegol Approved Phase 4 428863-50-7
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2
7
Azathioprine Approved Phase 3 446-86-6 2265
8
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
9 glucocorticoids Phase 3,Phase 2
10 Ferrosoferric Oxide Phase 2, Phase 3
11 Hematinics Phase 2, Phase 3
12 Hormone Antagonists Phase 3,Phase 2
13 Hormones Phase 3,Phase 2
14 Parenteral Nutrition Solutions Phase 2, Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Pharmaceutical Solutions Phase 2, Phase 3
17 Immunosuppressive Agents Phase 3,Phase 2
18 Antimetabolites Phase 3
19 Anti-Inflammatory Agents Phase 3,Phase 2
20 Antimetabolites, Antineoplastic Phase 3
21 Antineoplastic Agents, Hormonal Phase 3,Phase 2
22 Adrenergic Agents Phase 2, Phase 3
23 Adrenergic Antagonists Phase 2, Phase 3
24 Adrenergic beta-Antagonists Phase 2, Phase 3
25 Neurotransmitter Agents Phase 2, Phase 3
26 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
27
Iron Approved Phase 2 7439-89-6 23925
28
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
29
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
30
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
31
Epirubicin Approved Phase 2 56420-45-2 41867
32
Lenograstim Approved, Investigational Phase 2 135968-09-1
33 Protective Agents Phase 2
34 Prednisolone acetate Phase 2
35 Methylprednisolone acetate Phase 2
36 Methylprednisolone Hemisuccinate Phase 2
37 Muromonab-CD3 Phase 2
38 Gastrointestinal Agents Phase 2
39 Neuroprotective Agents Phase 2
40 Cyclosporins Phase 2
41 Dermatologic Agents Phase 2
42 Peripheral Nervous System Agents Phase 2
43 Antiemetics Phase 2
44 Anti-Infective Agents Phase 2
45 Antifungal Agents Phase 2
46 Prednisolone hemisuccinate Phase 2
47 Prednisolone phosphate Phase 2
48 Autonomic Agents Phase 2
49 Calcineurin Inhibitors Phase 2
50 Fluorodeoxyglucose F18 Phase 2

Interventional clinical trials:

(show top 50) (show all 64)

# Name Status NCT ID Phase Drugs
1 RHYTHM (Formerly Escape II Myocardium) Recruiting NCT01548768 Phase 4 TNF inhibitors;DMARDs
2 CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial) Unknown status NCT01877746 Phase 3 Combination of prednisone and azathioprine;Combination of prednisone and azathioprine
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
4 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
5 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
6 COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF Withdrawn NCT02582190 Phase 3 Colchicine group
7 IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN Unknown status NCT01995799 Phase 2
8 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
9 Myocarditis Treatment Trial Completed NCT00000524 Phase 2 cyclosporine;prednisone
10 Late Cardiac Evaluation of the Three Arm Belgian Trial Involving Node-positive Early Breast Cancer Patients Completed NCT01554943 Phase 2
11 PET/MRI Imaging of Cardiac Sarcoidosis Recruiting NCT03103490 Phase 2 F18 FSPG
12 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Recruiting NCT03048097 Phase 2 Fluorodeoxyglucose;Rubidium
13 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
14 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
15 Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy Completed NCT02028403 Phase 1 BMS-936559;Placebo for BMS-936559
16 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
17 International Myocarditis Registry Unknown status NCT01307735
18 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
19 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients Unknown status NCT01089036
20 2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis Unknown status NCT01092429
21 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
22 Implementation of Work in Progress (WIP) Sequences in Magnetic Resonance Imaging (MRI) Unknown status NCT01019226
23 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
24 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
25 Magnetic Resonance Imaging in Myocarditis Completed NCT02177630
26 Risk Factors for Predictors of In-hospital Death in Acute Fulminant Myocarditis Completed NCT03219996
27 CMR in Patients With Myocarditis Completed NCT01962584
28 Study of Muromonab-CD3 and Cyclosporine in Patients With Giant Cell Myocarditis Completed NCT00027443 Muromonab-CD3;Cyclosporine
29 Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis Completed NCT00693134
30 Evaluation of Reporting of Immune Checkpoint Inhibitor Associated Cardio-vascular Adverse Reactions Completed NCT03387540 ICI
31 Safety Surveillance Study of ACAM2000® Vaccinia Vaccine Completed NCT00927719
32 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
33 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531
34 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
35 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
36 Inflammatory Cardiomyopathy Baseline Cohort (SFB/TR19) Completed NCT02970227
37 Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death Completed NCT01919983
38 Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection Completed NCT00426699
39 CMR Features in Patients With Suspected Myocarditis Completed NCT03470571
40 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Recruiting NCT02717143
41 Clinical Assessment of New Treatment Regimen for Adult Fulminant Myocarditis Recruiting NCT03268642
42 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721
43 Myocarditis Registry for Children and Adolescents - MYKKE Recruiting NCT02590341
44 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
45 Quantitative Cardiac Parametric Mapping (Myomapping) Recruiting NCT02855554
46 Cologne Register of Wearable Defibrillator (CRWD) Recruiting NCT02073942
47 PET MRI Study in Patients With Cardiac Sarcoidosis Recruiting NCT03356756
48 Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects Recruiting NCT02874703
49 Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study) Recruiting NCT02740179 Eplerenone;Placebo
50 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRI Recruiting NCT02318498

Search NIH Clinical Center for Myocarditis

Cochrane evidence based reviews: myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

MalaCards organs/tissues related to Myocarditis:

38
Heart, T Cells, Liver, Monocytes, Tonsil, B Cells, Bone

Publications for Myocarditis

Articles related to Myocarditis:

(show top 50) (show all 1968)
# Title Authors Year
1
MiRNA Signaling in Viral Myocarditis Novel and Unique Pathological Features. ( 29375227 )
2018
2
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis. ( 29428410 )
2018
3
A Case of Myocarditis and Near-Lethal Arrhythmia Associated With Interleukin-2 Therapy. ( 29399586 )
2018
4
Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection. ( 29433478 )
2018
5
Various Cardiac Abnormalities Caused by Bacterial Myocarditis. ( 29375113 )
2018
6
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
7
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
8
Levitronix bilateral ventricular assist device, a bridge to recovery in a patient with acute fulminant myocarditis and concomitant cerebellar infarction. ( 29443352 )
2018
9
Pediatric Viral Myocarditis - A Review. ( 29439302 )
2018
10
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
11
MR imaging of catecholamine-mediated myocarditis complicated by left ventricular thrombus. ( 29396086 )
2018
12
Images of atrial giant cell myocarditis. ( 29186397 )
2018
13
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
14
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
15
Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma. ( 29444608 )
2018
16
Ulinastatin Protects against CVB3-Induced Acute Viral Myocarditis through Nrf2 Activation. ( 29383542 )
2018
17
Early use of anakinra in adult-onset Still's disease myocarditis. ( 29291663 )
2018
18
Acute myocarditis secondary to acute<i>Campylobacter jejuni</i>infection. ( 29436448 )
2018
19
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort. ( 29306448 )
2018
20
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
21
When Lightning Strikes Twice in Pediatrics: Case Report and Review of Recurrent Myocarditis. ( 29437909 )
2018
22
The search for water: Is it so easy to diagnose acute myocarditis? ( 29435861 )
2018
23
Pancreatitis and myocarditis coexistence due to infection by Coxsackie B1 and B4 viruses. ( 29375831 )
2018
24
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
25
Lymphocyte-Variant Hypereosinophilic Syndrome With Eosinophilic Myocarditis Treated With Steroids and Pegylated Interferon Alfa-2a. ( 29406050 )
2018
26
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
27
Influence of echocardiographic measurements and renal impairments on the prognosis of fulminant myocarditis. ( 29384884 )
2018
28
Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. ( 29391679 )
2018
29
Still poor prognosis for patients with giant cell myocarditis in the era of temporary mechanical circulatory supports. ( 29306450 )
2018
30
Non-invasive differentiation of idiopathic inflammatory myopathy with cardiac involvement from acute viral myocarditis using cardiovascular magnetic resonance imaging T1 and T2 mapping. ( 29429407 )
2018
31
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
32
Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-I_B and PI3K/Akt signaling pathway in mice. ( 28485793 )
2017
33
Branched chain I+-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. ( 28597552 )
2017
34
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. ( 28410530 )
2017
35
Assessment of edema using STIR+ via 3D cardiovascular magnetic resonance imaging in patients with suspected myocarditis. ( 28091836 )
2017
36
Parvovirus B19 Myocarditis of Fulminant Evolution. ( 28868104 )
2017
37
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
38
Outcomes of Heart Block in Myocarditis: A Review of 31,760 Patients. ( 29402690 )
2017
39
Clinical and magnetic resonance evolution of "infarct-like" myocarditis. ( 28070840 )
2017
40
Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. ( 28772042 )
2017
41
Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis. ( 28902285 )
2017
42
Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients. ( 28042125 )
2017
43
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
44
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
45
Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis WithA Preserved Systolic Function: ITAMY Study. ( 29025554 )
2017
46
Ferumoxytol in acute myocarditis: 'keep your head in the clouds and your feet on the earth'. ( 28780574 )
2017
47
Sudden death and acute myocarditis: a unique forensic case of double origin of coronary arteries. ( 28928257 )
2017
48
Correction to: When Lightning Strikes: Fulminant Myocarditis in the Realm of Inflammatory Cardiomyopathies. ( 28893968 )
2017
49
Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. ( 28584814 )
2017
50
Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis. ( 29158436 )
2017

Variations for Myocarditis

Expression for Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for Myocarditis

Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD40 CD40LG CD55 CD86 CXADR DSP
2
Show member pathways
13.41 CD40 CD40LG CD86 CXADR HLA-B HLA-DQB1
3
Show member pathways
13.24 CD40 CD40LG CD86 HLA-B HLA-DQB1 ICAM1
4
Show member pathways
12.56 CD40 CD40LG CD86 HLA-DQB1 IL12RB1 TNF
5
Show member pathways
12.37 DAG1 DMD DSP ITGB2
6
Show member pathways
12.34 CD40 CD40LG CD86 HLA-DQB1
7 12.34 CD40 HLA-B HLA-DQB1 ICAM1 ITGB2 TNF
8
Show member pathways
12.29 ICAM1 ITGB2 MYH6 NOS2
9 12.25 CD40 HLA-B HLA-DQB1 ICAM1
10
Show member pathways
12.18 CD40 CD40LG CD55 CD86 CXADR DAG1
11 12.17 HLA-DQB1 ITGB2 NOS2 TNF
12
Show member pathways
12.15 DAG1 DMD MYH6 TNF TNNI3
13
Show member pathways
12.12 CD40 CD40LG HLA-DQB1 ITGB2 NOS2 TNF
14 11.95 CXADR DSP ICAM1 ITGB2
15 11.93 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
16 11.91 ICAM1 ITGB2 NOS2 TNF
17 11.86 CD40 CD40LG CD86 HLA-B HLA-DQB1 ICAM1
18 11.84 CD55 HLA-DQB1 TNF
19 11.83 ITGB2 NOS2 TNF
20 11.82 CD40 CD40LG ICAM1 TNF
21 11.76 CD86 HLA-DQB1 ICAM1 ITGB2 TNF
22
Show member pathways
11.75 CD40 CD40LG TNF
23 11.71 ITGB2 NOS2 TNF
24
Show member pathways
11.69 CD40 CD40LG TNF
25 11.68 DMD MYH6 TNNI3
26
Show member pathways
11.6 CD40LG ICAM1 NOS2 TNF
27 11.56 CD40 CD40LG CD86
28 11.54 HLA-DQB1 ICAM1 ITGB2
29 11.51 CD40 CD40LG CD86
30 11.46 CD86 ICAM1 TNF
31 11.45 ICAM1 ITGB2 TNF
32 11.44 ITGB2 NOS2 TNF
33 11.34 CD40 CD40LG ICAM1 ITGB2 TNF
34 11.32 HLA-B ICAM1 NOS2
35 11.25 CD40 CD40LG CD86
36 11.25 CD40 CD40LG ICAM1 ITGB2 NOS2 TNF
37 10.54 MB NOS2

GO Terms for Myocarditis

Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.63 CD40 CD40LG DAG1 ICAM1 ITGB2 TNF
2 filopodium GO:0030175 9.58 CXADR DAG1 DMD
3 ficolin-1-rich granule membrane GO:0101003 9.54 CD55 DSP ITGB2
4 myofibril GO:0030016 9.5 DMD MYH6 TNNI3
5 membrane raft GO:0045121 9.43 CD55 CXADR DAG1 DMD ICAM1 TNF
6 cell surface GO:0009986 9.28 CD40 CD40LG CD55 CD86 DMD HLA-B
7 extracellular exosome GO:0070062 10.13 CD40 CD55 CD86 DAG1 DSP HLA-B
8 plasma membrane GO:0005886 10.1 CD40 CD40LG CD55 CD86 CXADR DAG1

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 CD40 CD40LG CD86 HLA-B HLA-DQB1 TNF
2 leukocyte migration GO:0050900 9.86 CXADR ICAM1 ITGB2 TNF
3 extracellular matrix organization GO:0030198 9.84 DAG1 ICAM1 ITGB2 TNF
4 viral process GO:0016032 9.8 CD55 CD86 CXADR DAG1 HLA-B ICAM1
5 cellular response to interferon-gamma GO:0071346 9.77 ICAM1 IL12RB1 NOS2
6 T cell costimulation GO:0031295 9.75 CD40LG CD86 HLA-DQB1
7 interferon-gamma-mediated signaling pathway GO:0060333 9.74 HLA-B HLA-DQB1 ICAM1
8 cellular response to lipopolysaccharide GO:0071222 9.73 CD40 ICAM1 NOS2 TNF
9 cardiac muscle contraction GO:0060048 9.69 DMD MYH6 TNNI3
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 ICAM1 ITGB2 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 CD40 CD40LG ICAM1 ITGB2 TNF
12 muscle filament sliding GO:0030049 9.63 DMD MYH6 TNNI3
13 regulation of immune response GO:0050776 9.63 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
14 response to denervation involved in regulation of muscle adaptation GO:0014894 9.58 DAG1 DMD
15 cardiac muscle fiber development GO:0048739 9.55 CXADR MYH6
16 leukocyte cell-cell adhesion GO:0007159 9.54 CD40LG ICAM1 ITGB2
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 ICAM1 TNF
18 cellular extravasation GO:0045123 9.48 ITGB2 TNF
19 regulation of immunoglobulin secretion GO:0051023 9.13 CD40 CD40LG TNF
20 viral entry into host cell GO:0046718 9.02 CD55 CD86 CXADR DAG1 ICAM1

Molecular functions related to Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.56 CD40 CD86 ICAM1 ITGB2
2 vinculin binding GO:0017166 9.32 DAG1 DMD
3 dystroglycan binding GO:0002162 9.16 DAG1 DMD
4 cell adhesion molecule binding GO:0050839 9.13 CXADR DSP ITGB2
5 virus receptor activity GO:0001618 9.02 CD55 CD86 CXADR DAG1 ICAM1

Sources for Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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