MCID: MYC008
MIFTS: 54

Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Myocarditis

Summaries for Myocarditis

NIH Rare Diseases : 50 myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). some affected people have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. it can also be associated with other inflammatory conditions such as lupus, wegener's granulomatosis, giant cell arteritis and takayasu's arteritis. most cases occur sporadically in people with no family history of the condition. treatment aims to address the underlying cause of the condition. medications and rarely, a heart transplant may be needed if the heart muscle becomes weak. last updated: 3/15/2016

MalaCards based summary : Myocarditis, also known as myocardial inflammation, is related to celiac disease and congestive heart failure. An important gene associated with Myocarditis is DMD (Dystrophin), and among its related pathways/superpathways are Viral myocarditis and Innate Immune System. The drugs Methotrexate and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

Disease Ontology : 12 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Wikipedia : 71 Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle. Symptoms... more...

Related Diseases for Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
id Related Disease Score Top Affiliating Genes
1 celiac disease 29.7 CD40LG HLA-B TNF
2 congestive heart failure 29.5 CD40 CD40LG CD86 TNF
3 glomerulonephritis 29.4 DMD MB TNNI3
4 tuberculosis 28.8 CD40LG CXADR MYH6 TNF TNNI3
5 giant cell myocarditis 12.3
6 autoimmune myocarditis 12.2
7 rheumatic myocarditis 12.2
8 acute myocarditis 12.2
9 fiedler's myocarditis 12.1
10 septic myocarditis 12.0
11 interstitial myocarditis 11.9
12 toxic myocarditis 11.9
13 infectious myocarditis 11.8
14 post-infectious myocarditis 11.7
15 diphtheria 11.3
16 trichinosis 11.1
17 chagas disease 11.1
18 cardiomyopathy 10.4
19 parasitic ichthyosporea infectious disease 10.3 CD40 CD86 TNF
20 adrenal gland ganglioneuroblastoma 10.3 CD40LG MB
21 hyperparathyroidism, primary, caused by water clear cell hyperplasia 10.3 CD40 CD40LG
22 trabecular follicular adenocarcinoma 10.3 CD40 CD86 TNNI3
23 bulbospinal polio 10.3 CD40 CD40LG CD86
24 disease of mental health 10.2 CD40LG HLA-B TNF
25 myocardial infarction 10.2
26 dilated cardiomyopathy 10.2
27 autosomal recessive nonsyndromic deafness 47 10.2 DAG1 DMD
28 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 HLA-B HLA-DQB1 TNF
29 uveitis 10.2 CD40LG ICAM1 TNF
30 dermatomycosis 10.2 CD40LG ICAM1 TNF
31 acute cholangitis 10.2 CD40LG HLA-B TNF
32 conduct disorder 10.2 CD40LG ICAM1 TNF
33 oral cavity cancer 10.2 CD40LG ICAM1 TNF
34 powassan encephalitis 10.2 CD40LG ICAM1 TNF
35 voyeurism 10.2 CD40LG MB TNNI3
36 dracunculiasis 10.2 CD40LG ICAM1 TNF
37 anterior foramen magnum meningioma 10.2 CD40LG HLA-B TNF
38 radial hypoplasia, triphalangeal thumbs and hypospadias 10.2 CD40LG ITGB2 TNF
39 hallucinogen dependence 10.2 CD40 CD40LG TNF
40 epimerase deficiency galactosemia 10.2 DMD NOS2 TNF
41 xanthogranulomatous cholecystitis 10.2 CD40LG ICAM1 TNF
42 endobronchial leiomyoma 10.2 CD40LG HLA-B TNF
43 unilateral retinoblastoma 10.2 CD40LG IL12RB1
44 choreatic disease 10.2 CD40LG HLA-DQB1 TNF
45 chromoblastomycosis 10.2 ICAM1 NOS2 TNF
46 pemphigus vulgaris, familial 10.2 CD40LG HLA-B ICAM1 TNF
47 glaucoma iridogoniodysgenesia 10.2 HLA-B MB
48 geniculate ganglionitis 10.2 CD55 ICAM1 MB TNF
49 tonsil cancer 10.1 CD40LG ICAM1
50 cryptococcosis 10.1 CD40LG HLA-B HLA-DQB1 TNF

Comorbidity relations with Myocarditis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Myocardial Ischemia
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to Myocarditis

Symptoms & Phenotypes for Myocarditis

GenomeRNAi Phenotypes related to Myocarditis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 HLA-DQB1 ICAM1 NOS2 TNF CD40LG DAG1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 ICAM1 NOS2 TNF CD40 CD40LG DAG1

MGI Mouse Phenotypes related to Myocarditis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 CD40LG CXADR DAG1 DMD DSP HLA-DQB1
2 cellular MP:0005384 10.27 CD40LG CD86 CXADR DAG1 DMD DSP
3 behavior/neurological MP:0005386 10.24 CD55 CD86 CXADR DAG1 DMD HLA-DQB1
4 hematopoietic system MP:0005397 10.18 MB NOS2 TNF CD40 CD40LG CD55
5 homeostasis/metabolism MP:0005376 10.17 CD40 CD40LG CD86 CXADR DAG1 DMD
6 endocrine/exocrine gland MP:0005379 10.06 CD40LG CD86 CXADR DMD HLA-DQB1 ICAM1
7 immune system MP:0005387 10 CD40 CD40LG CD86 CXADR DMD HLA-DQB1
8 mortality/aging MP:0010768 10 MYH6 NOS2 TNF TNNI3 TXN CD40LG
9 digestive/alimentary MP:0005381 9.98 CXADR DMD DSP HLA-DQB1 ICAM1 NOS2
10 muscle MP:0005369 9.73 ICAM1 MB MYH6 NOS2 TNF TNNI3
11 respiratory system MP:0005388 9.17 HLA-DQB1 MB NOS2 TNF TNNI3 CXADR

Drugs & Therapeutics for Myocarditis

Drugs for Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
2
Adalimumab Approved Phase 4 331731-18-1 16219006
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Infliximab Approved Phase 4 170277-31-3
5
Certolizumab pegol Approved Phase 4 428863-50-7
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2
7
Azathioprine Approved Phase 3 446-86-6 2265
8
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
9
Colchicine Approved Phase 3 64-86-8 6167 2833
10 glucocorticoids Phase 3,Phase 2
11 Hematinics Phase 2, Phase 3
12 Hormone Antagonists Phase 3,Phase 2
13 Hormones Phase 3,Phase 2
14 Parenteral Nutrition Solutions Phase 2, Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Pharmaceutical Solutions Phase 2, Phase 3
17 Ferrosoferric Oxide Phase 2, Phase 3
18 Immunosuppressive Agents Phase 3,Phase 2
19 Anti-Inflammatory Agents Phase 3,Phase 2
20 Antimetabolites Phase 3
21 Antimetabolites, Antineoplastic Phase 3
22 Antineoplastic Agents, Hormonal Phase 3,Phase 2
23 Adrenergic Agents Phase 2, Phase 3
24 Adrenergic Antagonists Phase 2, Phase 3
25 Neurotransmitter Agents Phase 2, Phase 3
26 Adrenergic beta-Antagonists Phase 2, Phase 3
27 Anti-Arrhythmia Agents Phase 3
28 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
29 Antimitotic Agents Phase 3
30
Iron Approved Phase 2 7439-89-6 23925
31
Cyclosporine Approved, Investigational, Vet_approved Phase 2 79217-60-0, 59865-13-3 5284373 6435893
32
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
33
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
34
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
35
Epirubicin Approved Phase 2 56420-45-2 41867
36
Lenograstim Approved Phase 2 135968-09-1
37 Protective Agents Phase 2
38 Prednisolone acetate Phase 2
39 Muromonab-CD3 Phase 2
40 Gastrointestinal Agents Phase 2
41 Neuroprotective Agents Phase 2
42 Dermatologic Agents Phase 2
43 Peripheral Nervous System Agents Phase 2
44 Prednisolone hemisuccinate Phase 2
45 Prednisolone phosphate Phase 2
46 Anti-Infective Agents Phase 2
47 Antiemetics Phase 2
48 Antifungal Agents Phase 2
49 Methylprednisolone acetate Phase 2
50 Methylprednisolone Hemisuccinate Phase 2

Interventional clinical trials:

(show top 50) (show all 53)
id Name Status NCT ID Phase
1 RHYTHM (Formerly Escape II Myocardium) Recruiting NCT01548768 Phase 4
2 CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial) Unknown status NCT01877746 Phase 3
3 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3
4 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Not yet recruiting NCT03018834 Phase 2, Phase 3
5 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
6 COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF Not yet recruiting NCT02582190 Phase 3
7 IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN Unknown status NCT01995799 Phase 2
8 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2
9 Myocarditis Treatment Trial Completed NCT00000524 Phase 2
10 Late Cardiac Evaluation of the Three Arm Belgian Trial Involving Node-positive Early Breast Cancer Patients Completed NCT01554943 Phase 2
11 Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82 Recruiting NCT03048097 Phase 2
12 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2
13 PET/MR Imaging of Cardiac Sarcoidosis or Inflammation Not yet recruiting NCT03103490 Phase 2
14 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2
15 Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy Completed NCT02028403 Phase 1
16 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
17 International Myocarditis Registry Unknown status NCT01307735
18 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
19 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients Unknown status NCT01089036
20 2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis Unknown status NCT01092429
21 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
22 Implementation of Work in Progress (WIP) Sequences in Magnetic Resonance Imaging (MRI) Unknown status NCT01019226
23 Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death Unknown status NCT01919983
24 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
25 Study of Muromonab-CD3 and Cyclosporine in Patients With Giant Cell Myocarditis Completed NCT00027443
26 CMR in Patients With Myocarditis Completed NCT01962584
27 Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis Completed NCT00693134
28 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531
29 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
30 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
31 Inflammatory Cardiomyopathy Baseline Cohort (SFB/TR19) Completed NCT02970227
32 Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection Completed NCT00426699
33 Myocarditis Registry for Children and Adolescents - MYKKE Recruiting NCT02590341
34 PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC Recruiting NCT02989480
35 Quantitative Cardiac Parametric Mapping (Myomapping) Recruiting NCT02855554
36 Cologne Register of Wearable Defibrillator (CRWD) Recruiting NCT02073942
37 Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects Recruiting NCT02874703
38 Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study) Recruiting NCT02740179
39 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRI Recruiting NCT02318498
40 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Recruiting NCT02527330
41 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
42 Follow-up of the Cardiomyopathy Cohort SFB/TR19 Recruiting NCT02971267
43 German Centre for Cardiovascular Research Cardiomyopathy Register Recruiting NCT02187263
44 Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis Recruiting NCT02655718
45 Magnetic Resonance Imaging in Myocarditis Active, not recruiting NCT02177630
46 ACAM2000® Myopericarditis Registry Active, not recruiting NCT01395082
47 18F-deoxyglucose (FDG) PET-CMD Active, not recruiting NCT02078141
48 Safety Surveillance Study of ACAM2000® Vaccinia Vaccine Active, not recruiting NCT00927719
49 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Not yet recruiting NCT02717143
50 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Not yet recruiting NCT02905721

Search NIH Clinical Center for Myocarditis

Cochrane evidence based reviews: myocarditis

Genetic Tests for Myocarditis

Anatomical Context for Myocarditis

MalaCards organs/tissues related to Myocarditis:

39
Heart, T Cells, Monocytes, Liver, Tonsil, Bone, B Cells

Publications for Myocarditis

Articles related to Myocarditis:

(show top 50) (show all 1852)
id Title Authors Year
1
A Pitfall in the Diagnosis of Eosinophilic Myocarditis in a Patient who Received Steroid Therapy. ( 28090045 )
2017
2
T1 mapping cardiovascular magnetic resonance imaging to detect myocarditis-Impact of slice orientation on the diagnostic performance. ( 28027767 )
2017
3
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
4
Epsilon wave on an electronic loop in a case of Arrhythmogenic Right Ventricular Dysplasia with myocarditis: an updated definition of the Epsilon wave. ( 28062531 )
2017
5
Is colchicine really harmful in viral myocarditis? ( 28029412 )
2017
6
Assessment of edema using STIR+ via 3D cardiovascular magnetic resonance imaging in patients with suspected myocarditis. ( 28091836 )
2017
7
Noninvasive Imaging of Myocardial Inflammation in Myocarditis using (68)Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography. ( 28042344 )
2017
8
Clinical and magnetic resonance evolution of "infarct-like" myocarditis. ( 28070840 )
2017
9
Biventricular endomyocardial biopsy in patients with suspected myocarditis: Feasibility, complication rate and additional diagnostic value. ( 28040278 )
2017
10
Lymphocytic myocarditis occurs with myocardial infarction and coincides with increased inflammation, hemorrhage and instability in coronary artery atherosclerotic plaques. ( 28087177 )
2017
11
Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients. ( 28042125 )
2017
12
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
13
Mid-term Risk for Subclinical Atherosclerosis and Chronic Myocarditis in Children with Kawasaki Disease and Transient Coronary Abnormalities. ( 28512721 )
2017
14
Established and novel treatment options in acute myocarditis, with or without heart failure. ( 27858465 )
2017
15
Viral Nucleic Acids in the Serum Are Dependent on Blood Sampling Site in Patients with Clinical Suspicion of Myocarditis. ( 28081531 )
2017
16
Diagnosing myocarditis with magnetic resonance. ( 28092291 )
2017
17
Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. ( 27100527 )
2016
18
Detection and molecular characterization of a novel piscine-myocarditis-like virus from baitfish in the USA. ( 27143135 )
2016
19
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2016
20
Fructus Amomi Cardamomi extract inhibit coxsackievirus-B3 induced myocarditis in murine myocarditis model. ( 27558433 )
2016
21
Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis. ( 27436306 )
2016
22
Human herpesvirus-6 and herpes simplex virus-1 as a cause of cardiomyopathy secondary to myocarditis in children. ( 28008734 )
2016
23
WITHDRAWN: Herbal medicines for viral myocarditis. ( 27142939 )
2016
24
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. ( 27440853 )
2016
25
Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. ( 27913009 )
2016
26
Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-I+, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children. ( 27997912 )
2016
27
Azathioprine-induced eosinophilic myocarditis in a patient with ANCA-associated vasculitis. ( 26950304 )
2016
28
Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair. ( 27323110 )
2016
29
Acute Myocarditis With Very High Troponin but No Ventricular Dysfunction. ( 27356633 )
2016
30
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2016
31
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging. ( 27526359 )
2016
32
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. ( 26696258 )
2016
33
Cardiac MRI and acute myocarditis. ( 28062736 )
2016
34
Giant Cell Myocarditis: A Brief Review. ( 27922771 )
2016
35
Fatal Dengue Myocarditis despite the Use of Extracorporeal Membrane Oxygenation. ( 28018687 )
2016
36
Pheochromocytoma Is Characterized byA Catecholamine-Mediated Myocarditis, Focal and Diffuse Myocardial Fibrosis, andA Myocardial Dysfunction. ( 27199060 )
2016
37
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. ( 27342875 )
2016
38
Usefulness of Late Iodine Enhancement on Spectral CT in Acute Myocarditis. ( 28017385 )
2016
39
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii. ( 27085128 )
2016
40
A case of an unexplained eosinophilic myocarditis in a dog. ( 27170173 )
2016
41
In vivo visualization of the blood separation in the left ventricular chamber: a case of fulminant myocarditis requiring venoarterial extracorporeal membrane oxygenation. ( 27530296 )
2016
42
Arrhythmic risk prediction of acute myocarditis presenting with life-threatening ventricular tachyarrhythmias. ( 27038726 )
2016
43
Left ventricular end-diastolic dimension as a predictive factor of outcomes in children with acute myocarditis. ( 27225897 )
2016
44
Incidence, Risk Factors, and Outcome of Life-Threatening Ventricular Arrhythmias in Giant Cell Myocarditis. ( 27913400 )
2016
45
Chikungunya Fever With Seizures, Myocarditis, and Severe Thrombocytopenia in a Child With Osteosarcoma. ( 27128980 )
2016
46
ST-segment elevation mimicking myocardial infarction after hydrochloric acid ingestion: Acute caustic myocarditis. ( 27570119 )
2016
47
Viral myocarditis. ( 27166925 )
2016
48
MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis. ( 27213338 )
2016
49
IL-33 enhances macrophage M2 polarization and protects mice from CVB3-induced viral myocarditis. ( 28041873 )
2016
50
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis. ( 27009192 )
2016

Variations for Myocarditis

Expression for Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for Myocarditis

Pathways related to Myocarditis according to KEGG:

37
id Name Kegg Source Accession
1 Viral myocarditis hsa05416

Pathways related to Myocarditis according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD40 CD40LG CD55 CD86 CXADR DSP
2
Show member pathways
13.41 CD40 CD40LG CD86 CXADR HLA-B HLA-DQB1
3
Show member pathways
13.24 CD40 CD40LG CD86 HLA-B HLA-DQB1 ICAM1
4
Show member pathways
12.56 CD40 CD40LG CD86 HLA-DQB1 IL12RB1 TNF
5
Show member pathways
12.37 DAG1 DMD DSP ITGB2
6
Show member pathways
12.34 CD40 CD40LG CD86 HLA-DQB1
7 12.34 CD40 HLA-B HLA-DQB1 ICAM1 ITGB2 TNF
8
Show member pathways
12.29 ICAM1 ITGB2 MYH6 NOS2
9 12.25 CD40 HLA-B HLA-DQB1 ICAM1
10
Show member pathways
12.18 CD40 CD40LG CD55 CD86 CXADR DAG1
11 12.17 HLA-DQB1 ITGB2 NOS2 TNF
12
Show member pathways
12.15 DAG1 DMD MYH6 TNF TNNI3
13
Show member pathways
12.12 CD40 CD40LG HLA-DQB1 ITGB2 NOS2 TNF
14 11.93 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
15 11.92 ICAM1 ITGB2 NOS2 TNF
16 11.89 CXADR DSP ICAM1 ITGB2
17 11.84 CD55 HLA-DQB1 TNF
18 11.83 ITGB2 NOS2 TNF
19 11.82 CD40 CD40LG ICAM1 TNF
20
Show member pathways
11.77 CD40 CD40LG TNF
21 11.76 CD86 HLA-DQB1 ICAM1 ITGB2 TNF
22 11.71 ITGB2 NOS2 TNF
23
Show member pathways
11.69 CD40 CD40LG TNF
24 11.68 DMD MYH6 TNNI3
25 11.66 CD40 CD40LG CD86 HLA-B HLA-DQB1 ICAM1
26
Show member pathways
11.6 CD40LG ICAM1 NOS2 TNF
27 11.57 CD40 CD40LG CD86
28 11.54 HLA-DQB1 ICAM1 ITGB2
29 11.51 CD40 CD40LG CD86
30 11.48 CD40 CD40LG ICAM1 ITGB2 NOS2 TNF
31 11.46 CD86 ICAM1 TNF
32 11.45 ICAM1 ITGB2 TNF
33 11.44 ITGB2 NOS2 TNF
34 11.34 CD40 CD40LG ICAM1 ITGB2 TNF
35 11.32 HLA-B ICAM1 NOS2
36 11.26 CD40 CD40LG CD86
37 10.54 MB NOS2

GO Terms for Myocarditis

Cellular components related to Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.63 CD55 CXADR DAG1 DMD ICAM1 TNF
2 filopodium GO:0030175 9.58 CXADR DAG1 DMD
3 ficolin-1-rich granule membrane GO:0101003 9.54 CD55 DSP ITGB2
4 myofibril GO:0030016 9.5 DMD MYH6 TNNI3
5 external side of plasma membrane GO:0009897 9.5 CD40 CD40LG CD86 DAG1 ICAM1 IL12RB1
6 cell surface GO:0009986 9.28 CD40 CD40LG CD55 CD86 DMD HLA-B
7 extracellular exosome GO:0070062 10.13 CD40 CD55 CD86 DAG1 DSP HLA-B
8 plasma membrane GO:0005886 10.1 CD40 CD40LG CD55 CD86 CXADR DAG1

Biological processes related to Myocarditis according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 CD40 CD40LG CD86 HLA-B HLA-DQB1 TNF
2 leukocyte migration GO:0050900 9.89 CXADR ICAM1 ITGB2 TNF
3 extracellular matrix organization GO:0030198 9.87 DAG1 ICAM1 ITGB2 TNF
4 response to lipopolysaccharide GO:0032496 9.86 CD40 CD86 ICAM1 NOS2
5 viral process GO:0016032 9.85 CD55 CD86 CXADR DAG1 HLA-B ICAM1
6 aging GO:0007568 9.84 CD86 DAG1 DMD ITGB2
7 T cell costimulation GO:0031295 9.77 CD40LG CD86 HLA-DQB1
8 interferon-gamma-mediated signaling pathway GO:0060333 9.76 HLA-B HLA-DQB1 ICAM1
9 cellular response to interferon-gamma GO:0071346 9.72 ICAM1 IL12RB1 NOS2
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40 CD40LG ICAM1 ITGB2 TNF
11 cardiac muscle contraction GO:0060048 9.7 DMD MYH6 TNNI3
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 ICAM1 ITGB2 TNF
13 muscle filament sliding GO:0030049 9.65 DMD MYH6 TNNI3
14 cellular response to lipopolysaccharide GO:0071222 9.65 CD40 CD86 ICAM1 NOS2 TNF
15 regulation of immune response GO:0050776 9.63 CD40 CD40LG CXADR HLA-B ICAM1 ITGB2
16 positive regulation of endothelial cell apoptotic process GO:2000353 9.61 CD40 CD40LG
17 response to denervation involved in regulation of muscle adaptation GO:0014894 9.61 DAG1 DMD
18 cardiac muscle fiber development GO:0048739 9.58 CXADR MYH6
19 leukocyte cell-cell adhesion GO:0007159 9.58 CD40LG ICAM1 ITGB2
20 cellular extravasation GO:0045123 9.49 ITGB2 TNF
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.46 ICAM1 TNF
22 regulation of immunoglobulin secretion GO:0051023 9.13 CD40 CD40LG TNF
23 viral entry into host cell GO:0046718 9.02 CD55 CD86 CXADR DAG1 ICAM1

Molecular functions related to Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.56 CD40 CD86 ICAM1 ITGB2
2 vinculin binding GO:0017166 9.32 DAG1 DMD
3 dystroglycan binding GO:0002162 9.16 DAG1 DMD
4 cell adhesion molecule binding GO:0050839 9.13 CXADR DSP ITGB2
5 virus receptor activity GO:0001618 9.02 CD55 CD86 CXADR DAG1 ICAM1

Sources for Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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