MCID: MYC008
MIFTS: 57

Myocarditis malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Myocarditis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle (myocardium). more...

MalaCards: Myocarditis, also known as myocardial inflammation, is related to acute myocarditis and dilated cardiomyopathy. An important gene associated with Myocarditis is IL12RB1 (interleukin 12 receptor, beta 1), and among its related pathways are Type II interferon signaling (IFNG) and Primary immunodeficiency. The compounds toxin-1 and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Aliases & Classifications for Myocarditis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

myocarditis 8 43 10 45 62
myocardial inflammation 8


External Ids:

Disease Ontology8 DOID:820
NCIt40 C34831
MeSH35 D009205
ICD9CM27 429.0

Related Diseases for Myocarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis31.8TXN, TNC
2dilated cardiomyopathy31.0CHKB, ADRB1, MYH6, TXN
3myocardial infarction30.9TNC, CIITA, ADRB1, CHKB
4acute myocardial infarction30.6TNC, TXN, ADRB1, CHKB
5sarcoidosis30.4TXN, IL2, IL12RB1
6ulcerative colitis30.3NOS2, IL12RB1, CHKB
7systemic lupus erythematosus30.2CIITA, ADRB1, ICOS, IL2, IL12RB1, IL10RA
8adult respiratory distress syndrome30.1NOS2, TXN
9arthritis30.0NOS2, CIITA, TXN
10congestive heart failure29.9TXN, ADRB1, CHKB
11coronary artery disease29.9TXN, ADRB1, CHKB
12type 1 diabetes mellitus29.8CIITA, NOS2
13hepatitis b29.8TXN, CIITA, IL2
14sepsis29.8TXN, CIITA, NOS2
15tuberculosis29.8IL12RB1, IL2, CIITA
16atopic dermatitis29.8IL10RA, IL12RB1, IL2
17autoimmune thyroiditis29.8CIITA, CHKB
18ischemia29.7TNC, CIITA, CHKB, NOS2
19asthma29.7NOS2, IL12RB1, CHKB, CIITA, TNC
20multiple sclerosis29.6TNC, CIITA, IL2, NOS2, CD274
21melanoma29.4TNC, TXN, CIITA, CHKB, IL2, IL10RA
22autoimmune myocarditis11.1
23giant cell myocarditis10.9
24rheumatic myocarditis10.6
25interstitial myocarditis10.5
26fiedler's myocarditis10.5
27toxic myocarditis10.5
28infectious myocarditis10.5
29influenza10.5
30atrioventricular block10.4
31pericarditis10.4
32thymoma10.4
33myositis10.3
34cardiogenic shock10.3
35lupus erythematosus10.3
36pneumonia10.3
37churg-strauss syndrome10.3
38polymyositis10.3
39trichinosis10.2
40cardiac tamponade10.2
41eosinophilia10.2
42hepatitis10.2
43myasthenia gravis10.2
44aneurysm10.2
45septic myocarditis10.2
46hypertrophic cardiomyopathy10.2
47tonsillitis10.2
48diphtheria10.2
49adult-onset still's disease10.2
50kawasaki disease10.2

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to myocarditis

Symptoms for Myocarditis

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Drugs & Therapeutics for Myocarditis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Myocarditis

Search NIH Clinical Center for Myocarditis

Genetic Tests for Myocarditis

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Anatomical Context for Myocarditis

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33MalaCards
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MalaCards organs/tissues related to Myocarditis:

33
Heart, T cells, Monocytes, Tonsil, Liver, Bone, B cells, Cardiac myocytes, Brain, Thyroid, Pancreas, Nk cells, Endothelial, Skeletal muscle, Thymus, Bone marrow, Testes, Lung, Kidney, Skin

Animal Models for Myocarditis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Myocarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4ADRB1, ICOS, IL2, NOS2, CIITA
2MP:00053868.1TNC, MYH6, CHKB, IL2, NOS2, CD274
3MP:00053977.4CIITA, ICOS, IL2, IL12RB1, IL10RA, NOS2
4MP:00053877.3CIITA, ICOS, IL2, IL12RB1, IL10RA, NOS2
5MP:00053766.4CD274, TNC, CIITA, MYH6, ADRB1, CHKB

Publications for Myocarditis

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Sources:
52PubMed
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Articles related to Myocarditis:

(show top 50)    (show all 1541)
idTitleAuthorsYear
1
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
2
Enteroviral myocarditis in neonates. (23711335)
2013
3
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
4
Thrombotic events in critically ill children with myocarditis. (24016733)
2013
5
Pericarditis, myocarditis, and other cardiomyopathies. (23402470)
2013
6
Fulminant human herpesvirus 6 myocarditis in an immunocompetent adult: role of cardiac magnetic resonance in a multidisciplinary approach. (24297820)
2013
7
Innate immune interleukin-1 receptor-associated kinase 4 exacerbates viral myocarditis by reducing CCR5(+) CD11b(+) monocyte migration and impairing interferon production. (24030499)
2013
8
Myocarditis: early biopsy allows for tailored regenerative treatment. (22685492)
2012
9
A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-I_B signaling. (23029542)
2012
10
Endocarditis and myocarditis: a brief review. (23098151)
2012
11
Autoimmunity against Ma88muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. (22328321)
2012
12
Pathogenesis of coxsackievirus B3-induced myocarditis: role of macrophage migration inhibitory factor. (22340465)
2012
13
Th2 regulation of viral myocarditis in mice: different roles for TLR3 versus TRIF in progression to chronic disease. (22013485)
2012
14
The mechanism of carvedilol in experimental viral myocarditis. (22443630)
2012
15
PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis. (20356766)
2011
16
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
17
Dengue myositis and myocarditis. (20739801)
2010
18
Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis. (18329552)
2008
19
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. (17588693)
2008
20
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
21
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
22
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
23
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
24
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
25
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome. (15837284)
2005
26
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
27
An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. (14613869)
2003
28
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
29
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
30
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
31
Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice. (9166288)
1997
32
Data on giant cell myocarditis sought for new study. (8616928)
1996
33
Announcement of multicenter giant-cell myocarditis study. (7677103)
1995
34
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
35
Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. (2396870)
1990
36
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
37
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
38
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
39
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
40
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985
41
A case of congestive cardiomyopathy with histological findings suggesting rheumatic myocarditis by endomyocardial biopsy. (6448932)
1980
42
Giant cell myocarditis. (6989338)
1980
43
A case of giant cell myocarditis. (4748147)
1973
44
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
45
Rheumatic myocarditis in an infant nine months of age. (5782817)
1969
46
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
47
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
48
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
49
Fiedler's myocarditis at age of two months. (13217368)
1954
50
Fulminating trichinosis with myocarditis. (13176789)
1954

Variations for Myocarditis

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Expression for genes affiliated with Myocarditis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for genes affiliated with Myocarditis

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 53QIAGEN, 5Cell Signaling Technology
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Pathways related to Myocarditis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS2, CIITA
29.8ICOS, CIITA
39.8IL2, NOS2
4
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.6IL2, IL12RB1, NOS2
5
Show member pathways
Type III interferon signaling38
9.5IL12RB1, IL10RA, IL2
69.5CIITA, IL10RA, NOS2
7
Show member pathways
9.2IL2, IL12RB1, IL10RA, MYH6
8
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL2, IL12RB1, IL10RA, NOS2
99.0TXN, CIITA, IL2
10
Show member pathways
8.9IL2, CD70, IL10RA, IL12RB1
11
Show member pathways
8.9IL10RA, TNC, MYH6, IL2, IL12RB1
12
Show member pathways
8.9CIITA, NOS2, IL10RA, IL12RB1, IL2
13
Show member pathways
8.5IL10RA, IL12RB1, IL2, ICOS, MYH6, CIITA

Compounds for genes affiliated with Myocarditis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1toxin-14510.2CIITA, IL2
2glatiramer acetate45 1111.2IL2, CIITA
3taurine chloramine4510.2NOS2, IL2
4il-124510.2IL12RB1, IL2
5minocycline45 1111.2NOS2, CIITA
6nebivolol45 1111.1NOS2, ADRB1
7triptolide4510.0NOS2, IL2
8polyinosinic-polycytidylic acid4510.0NOS2, IL2, CIITA
9xamoterol45 2910.8CHKB, ADRB1
10dobutamine45 29 51 1112.8ADRB1, CHKB
11isoproterenol45 1110.7NOS2, ADRB1, MYH6
12fotemustine45 1110.7IL2, TXN
13ebselen459.7TXN, NOS2
14gold sodium thiomalate459.7IL2, TXN
15rosuvastatin45 51 29 1112.6NOS2, CHKB
16amiodarone45 51 29 1112.6ADRB1, CHKB
17auranofin29 45 61 1112.6TXN, IL2
18endotoxin459.6NOS2, CHKB, CIITA
19triiodothyronine459.5MYH6, ADRB1, CHKB
20rantes459.5CD70, IL2, CIITA
21guanidine45 24 1111.5CHKB, NOS2
22salbutamol45 51 29 24 1113.5ADRB1, CHKB
23cerivastatin51 45 29 1112.4CHKB, NOS2
24chloramphenicol45 3 51 1112.3MYH6, TXN, TNC
25pge2459.3NOS2, IL2, CHKB, CIITA
26ionomycin459.3IL2, IL12RB1, CD274, CD70
27gssg459.2TXN, CHKB
28carnitine459.2TXN, MYH6, CHKB
29isotretinoin45 1110.1IL2, CHKB, TXN
30peroxynitrite459.1TXN, CHKB, NOS2
31gsno459.0TXN, NOS2
32thyroxine45 249.9TXN, CIITA, MYH6, CHKB
33n acetylcysteine458.9TXN, CHKB, NOS2
34actinomycin d458.9TNC, TXN, CIITA, IL2, NOS2
35ascorbic acid45 249.8NOS2, CHKB, TXN, TNC
36cycloheximide458.8TNC, TXN, CIITA, IL2, NOS2
37tyrosine458.8TNC, CIITA, ADRB1, IL2, IL12RB1, IL10RA
38cyclosporin a45 29 6110.8TXN, CIITA, CHKB, IL2
39h2o2458.7TNC, TXN, CHKB, NOS2
40nitric oxide45 24 1110.7CIITA, ADRB1, CHKB, NOS2, CD274
41adenylate458.6TXN, ADRB1, CHKB, NOS2
42estrogen458.5TNC, TXN, MYH6, CHKB, NOS2
43calcium45 51 24 1111.5TNC, CIITA, MYH6, ADRB1, CHKB, NOS2
44vegf458.5TNC, TXN, CHKB, IL2, NOS2
45arginine458.4TXN, MYH6, ADRB1, CHKB, NOS2
46glutamate458.4TNC, TXN, ADRB1, CHKB, NOS2
47alanine458.3CHKB, ADRB1, CIITA, TXN
48oxygen45 249.1TXN, CIITA, MYH6, ADRB1, CHKB, NOS2
49serine458.0TNC, TXN, CIITA, MYH6, ADRB1, IL2
50dexamethasone45 51 29 1110.0CD274, TNC, TXN, CIITA, ADRB1, CHKB

GO Terms for genes affiliated with Myocarditis

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16Gene Ontology
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Cellular components related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD274, IL12RB1, ICOS

Biological processes related to Myocarditis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.9IL2, IL12RB1
2cellular response to interferon-gammaGO:0713469.9NOS2, IL12RB1
3positive regulation of interferon-gamma productionGO:0327299.9IL12RB1, IL2
4cytokine-mediated signaling pathwayGO:0192219.4CIITA, IL12RB1, IL10RA
5immune responseGO:0069558.6CD70, CD274, IL2, ICOS, CIITA
6cell-cell signalingGO:0072678.5CD70, IL2, TXN
7signal transductionGO:0071658.1TXN, IL12RB1, IL10RA, CD274, CD70

Products for genes affiliated with Myocarditis

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Sources for Myocarditis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet