MCID: MYC008
MIFTS: 56

Myocarditis malady

Summaries for Myocarditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle (myocardium). more...

MalaCards: Myocarditis, also known as myocarditis, unspecified, is related to acute myocarditis and dilated cardiomyopathy. An important gene associated with Myocarditis is MYH6 (myosin, heavy chain 6, cardiac muscle, alpha), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Myocarditis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

myocarditis 8 42 10 44 60
myocarditis, unspecified 8
myocardial inflammation 8
myocarditis nos 8


External Ids:

Disease Ontology8 DOID:820
ICD9CM27 429.0
NCIt39 C34831
MeSH34 D009205

Related Diseases for Myocarditis

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17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis31.7TNC, TXN
2dilated cardiomyopathy30.9TXN, MYH6, CXADR
3myocardial infarction30.9TNC, CIITA, PTX3
4acute myocardial infarction30.8TXN, TNC, PTX3
5influenza30.6CIITA, TNFSF9, TXN
6lupus erythematosus30.4CD70
7systemic lupus erythematosus30.4LCN2, ICOS, CIITA, CD70, IL10RA, IL12RB1
8sarcoidosis30.3IL2, IL12RB1, TXN
9encephalitis30.1NOS2, CD68, CIITA
10arthritis30.0NOS2, CXCL2, CIITA, TXN
11celiac disease30.0CIITA
12leukemia29.9CXADR, CXCL2, IL2
13thyroiditis29.9CIITA
14severe combined immunodeficiency29.9IL2, CIITA
15melanoma29.6TXN, TNC, CIITA, CD68, CD274, CD70
16multiple sclerosis29.6TNC, TNFSF9, CIITA, CD274, IL2, NOS2
17asthma29.6NOS2, IL12RB1, CIITA, TNC, LCN2
18ischemia29.6LCN2, TNC, CIITA, CXCL2, NOS2
19tuberculosis29.6CIITA, IL12RB1, IL2
20hepatitis b29.6IL2, CIITA, TXN
21adenocarcinoma29.6LCN2, TNC, CXADR, IL10RA, NOS2
22vasculitis29.6PTX3, LCN2
23peritonitis29.6CXCL2
24wegener's granulomatosis29.6CIITA
25congenital heart defect29.6TXN, MYH6, CXADR
26diabetes mellitus29.6TXN
27rheumatic myocarditis10.5
28interstitial myocarditis10.5
29fiedler's myocarditis10.5
30toxic myocarditis10.5
31atrioventricular block10.4
32pericarditis10.3
33thymoma10.3
34myositis10.3
35pneumonia10.2
36giant cell myocarditis10.2
37churg-strauss syndrome10.2
38infectious myocarditis10.2
39trichinosis10.2
40cardiac tamponade10.2
41septic myocarditis10.2
42eosinophilia10.2
43hepatitis10.2
44myasthenia gravis10.2
45diphtheria10.1
46arrhythmogenic right ventricular dysplasia10.1
47ulcerative colitis10.1
48hypertrophic cardiomyopathy10.1
49tonsillitis10.1
50kawasaki disease10.1

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to myocarditis

Clinical Features for Myocarditis

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Drugs & Therapeutics for Myocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myocarditis

Drug clinical trials:

Search ClinicalTrials for Myocarditis

Search NIH Clinical Center for Myocarditis

Search CenterWatch for Myocarditis

Genetic Tests for Myocarditis

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Anatomical Context for Myocarditis

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32MalaCards
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MalaCards organs/tissues related to Myocarditis:

32
Heart, T cells, Monocytes, Tonsil, Bone, Liver, B cells, Cardiac myocytes, Brain, Thyroid, Endothelial, Nk cells, Pancreas, Skeletal muscle, Thymus, Bone marrow, Lung, Kidney, Skin, Testes

Animal Models for Myocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.4PTX3, LCN2, ICOS, TNFRSF9, TNFSF9, CIITA
2MP:000539711.2CD68, CIITA, TNFRSF9, ICOS, LCN2, CD274
3MP:000538411.0TXN, LCN2, ICOS, TNFRSF9, CIITA, CD274
4MP:000537610.9CIITA, TNC, ICOS, LCN2, MYH6, CD274
5MP:000537910.7PTX3, IL2, CXADR, CIITA

Publications for Myocarditis

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50PubMed
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Articles related to Myocarditis:

(show top 50)    (show all 1555)
idTitleAuthorsYear
1
Myocarditis and diffuse skeletal muscle oedema: new features of neuromyelitis optica spectrum disorder? A case report. (23846353)
2014
2
Enteroviral myocarditis in neonates. (23711335)
2013
3
Fulminant human herpesvirus 6 myocarditis in an immunocompetent adult: role of cardiac magnetic resonance in a multidisciplinary approach. (24297820)
2013
4
Dengue myocarditis in Singapore: two case reports. (23277366)
2013
5
Recurrent myocarditis--an important mimic of ischaemic myocardial infarction. (23465652)
2013
6
MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation. (23588407)
2013
7
Mononuclear cell secretome in autoimmune myocarditis. (23513211)
2013
8
MicroRNAs regulate the pathogenesis of CVB3-induced viral myocarditis. (23183417)
2013
9
Chest Pain as the Predominant Symptom in Myocarditis in Children. (23932238)
2013
10
Salmonella enteritidis induced myocarditis in a 16-year-old girl. (23188875)
2012
11
Management of atrial tachycardia in the newborn with enterovirus myocarditis. (22778684)
2012
12
Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats. (22923621)
2012
13
Monitoring in clozapine rechallenge after myocarditis. (21879872)
2011
14
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. (21928275)
2011
15
Aborted sudden death from Epstein-Barr myocarditis. (22288081)
2011
16
Acute myocarditis after urinary tract infection by Escherichia coli. (21094538)
2011
17
Gadolinium chelate kinetics in cardiac MR imaging of myocarditis: comparison to acute myocardial infarction and impact on late gadolinium enhancement. (21808201)
2011
18
Novel nonmajor histocompatibility complex-linked loci from mouse chromosome 17 confer susceptibility to viral-mediated chronic autoimmune myocarditis. (20729557)
2010
19
The role of endocarditis, myocarditis and pericarditis in qualitative and quantitative data analysis. (20049235)
2009
20
Giant cell myocarditis mimicking idiopathic fascicular ventricular tachycardia. (18267234)
2008
21
Epicardial catheter ablation of incessant ventricular tachycardia in giant cell myocarditis. (18462332)
2008
22
Giant cell myocarditis and heart transplantation. (18503975)
2008
23
Adult-onset Still's disease and myocarditis: successful treatment with intravenous immunoglobulin and maintenance of remission with etanercept. (17449487)
2007
24
Detection of myocarditis by contrast-enhanced MRI in patients presenting with acute coronary syndrome but no coronary stenosis. (17457796)
2007
25
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
26
Inflammation, ECG changes and pericardial effusion: whom to biopsy in suspected myocarditis? (16897143)
2006
27
Focal myocardial fibrosis and edema in acute myocarditis demonstrated by multislice computed tomography. (16274784)
2005
28
Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis. (15757958)
2005
29
Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. (12920582)
2004
30
High-dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the literature. (11905592)
2002
31
Magnetic resonance imaging in acute myocarditis: a case report and a review of literature. (12365479)
2002
32
Contribution of the innate immune system to autoimmune myocarditis: a role for complement. (11477411)
2001
33
Fc receptor-mediated inhibitory effect of immunoglobulin therapy on autoimmune giant cell myocarditis: concomitant suppression of the expression of dendritic cells. (11557742)
2001
34
Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics. (9920487)
1999
35
An inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune myocarditis in Lewis rats. (9916888)
1998
36
Giant cell myocarditis-like appearance after transplantation: an atypical manifestation of rejection? (7947893)
1994
37
Characterization of T cells infiltrating the heart in rats with experimental autoimmune myocarditis. Their similarity to extrathymic T cells in mice and the site of proliferation. (8515083)
1993
38
Characterization of cardiotin, a structural component in the myocard. (8269977)
1993
39
In vivo deposition of myosin-specific autoantibodies in the hearts of mice with experimental autoimmune myocarditis. (1602130)
1992
40
Antimyosin cardiac imaging in acute myocarditis. (2358582)
1990
41
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
42
Acute myocarditis associated with transient marked myocardial thickening and complete atrioventricular block. (6540151)
1984
43
A case of congestive cardiomyopathy with histological findings suggesting rheumatic myocarditis by endomyocardial biopsy. (6448932)
1980
44
Pathogenesis of myocarditis in Rocky Mountain spotted fever. (6767463)
1980
45
Clinical briefs. Acute myocarditis simulating myocardial infarction. (5131337)
1971
46
Coxsackie B5 virus responsible for acute myocarditis inucklings. (5439221)
1970
47
Steroid treatment of infectious toxic myocarditis. (13762672)
1960
48
Electrocardiogram of the month: acute myocarditis. (13320513)
1956
49
Interstitial myocarditis in infancy, report of a case. (14832525)
1951
50
Acute myocarditis as a sequel to infectious mononucleosis. (20286801)
1946

Genetic Variations for Myocarditis

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Expression for genes affiliated with Myocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myocarditis

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Pathways for genes affiliated with Myocarditis

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51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Myocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0TNC, TNFRSF9, TNFSF9, MYH6, CXCL2, IL10RA
2
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10.9TNFRSF9, TNFSF9, CD70, CXCL2, IL10RA, IL12RB1
3
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10.9IL12RB1, IL10RA, CXADR, MYH6, CIITA, ICOS
4
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10.8TNFRSF9, TNFSF9, MYH6, CXCL2, IL10RA, IL12RB1
5
Hide members
10.8TNFRSF9, TNFSF9, CXCL2, IL10RA, IL12RB1, IL2
6
Hide members
10.8TXN, ICOS, CIITA, CD274, CXADR, IL2
7
Hide members
10.8CIITA, IL10RA, IL12RB1, IL2, NOS2
8
Development PDGF signaling via STATs and NF-kB
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10.7IL10RA, IL12RB1, IL2, NOS2
910.7NOS2, IL2, CXCL2

Compounds for genes affiliated with Myocarditis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Myocarditis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.4LCN2, TNC, TNFRSF9, CIITA, CXADR, CXCL2
2nitric oxide44 11 2413.2LCN2, CIITA, CD274, CXADR, CXCL2, NOS2
3dexamethasone44 49 28 1114.2PTX3, TXN, TNFRSF9, CIITA, CXADR, CXCL2
4actinomycin d4411.1TXN, TNC, CIITA, IL2, NOS2, PTX3
5ionomycin4411.1TNFRSF9, CD274, CD70, IL12RB1, IL2
6serine4411.1TXN, CIITA, MYH6, CXADR, CXCL2
7oxygen44 2412.0TXN, LCN2, CIITA, MYH6, CXCL2, NOS2
8estrogen4410.9TXN, LCN2, TNC, MYH6, CXCL2, NOS2
9polyinosinic-polycytidylic acid4410.9CIITA, IL2, NOS2
10ccl344 2811.9PTX3, CXCL2, TNFRSF9
11rantes4410.9CIITA, CXCL2, IL2
12neomycin4410.8IL2, CXADR, MYH6
13fotemustine44 1111.8IL2, TXN
14taurine chloramine4410.6NOS2, IL2
15glatiramer acetate44 1111.6IL2, CIITA
16toxin-14410.5CIITA, IL2
17gold sodium thiomalate4410.3IL2, TXN

GO Terms for genes affiliated with Myocarditis

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16Gene Ontology
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Cellular components related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9IL2, LCN2, TNC, TNFRSF9, TNFSF9, CD70
2external side of plasma membraneGO:00989710.7IL12RB1, CD274, TNFRSF9, ICOS
3extracellular regionGO:00557610.7TXN, LCN2, ICOS, TNC, CXADR, CXCL2

Biological processes related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.0IL2, ICOS, TNFSF9, CIITA, CD274, CD70
2signal transductionGO:00716510.7TXN, TNFSF9, CD274, CD70, IL10RA, IL12RB1
3cell-cell signalingGO:00726710.7TXN, TNFSF9, CD70, IL2
4cardiac muscle fiber developmentGO:04873910.7CXADR, MYH6
5positive regulation of activated T cell proliferationGO:04210410.6IL2, IL12RB1
6protein homotrimerizationGO:07020710.3TNFRSF9, LCN2

Molecular functions related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.7NOS2, CXADR, CD70, TNFSF9

Products for genes affiliated with Myocarditis

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  • Antibodies
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Sources for Myocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet