MCID: MYC008
MIFTS: 58

Myocarditis malady

Rare diseases, Cardiovascular diseases, Muscle diseases categories
Download this MalaCard

Summaries for Myocarditis

About this section


Fully expand this MalaCard
Wikipedia:65 Myocarditis or inflammatory cardiomyopathy is inflammation of heart muscle (myocardium). more...

MalaCards based summary: Myocarditis, also known as myocardial inflammation, is related to acute myocarditis and dilated cardiomyopathy. An important gene associated with Myocarditis is IL12RB1 (interleukin 12 receptor, beta 1), and among its related pathways are Type II interferon signaling (IFNG) and Primary immunodeficiency. The compounds toxin-1 and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle.

Aliases & Classifications for Myocarditis

About this section

Myocarditis, Aliases & Descriptions:

Name: Myocarditis 8 42 10 44 62
 
Myocardial Inflammation 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Muscle diseases


External Ids:

Disease Ontology8 DOID:820
NCIt39 C34831
MeSH34 D009205
ICD9CM27 429.0

Related Diseases for Myocarditis

About this section

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 293)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis32.3TXN, TNC
2dilated cardiomyopathy30.9MYH6, TXN, CHKB, ADRB1
3myocardial infarction30.9CHKB, ADRB1, CIITA, TNC
4sarcoidosis30.8TXN, IL12RB1, IL2
5acute myocardial infarction30.5TNC, ADRB1, TXN, CHKB
6adult respiratory distress syndrome30.5NOS2, TXN
7ulcerative colitis30.4IL12RB1, CHKB, NOS2
8type 1 diabetes mellitus30.2NOS2, CIITA
9common variable immunodeficiency30.1ICOS, IL2
10hepatitis b30.1TXN, IL2, CIITA
11sepsis30.1TXN, NOS2, CIITA
12congestive heart failure30.0ADRB1, CHKB, TXN
13arthritis30.0CIITA, TXN, NOS2
14tuberculosis30.0IL2, IL12RB1, CIITA
15autoimmune thyroiditis29.9CIITA, CHKB
16atopic dermatitis29.9IL10RA, IL12RB1, IL2
17ischemia29.7CHKB, CIITA, TNC, NOS2
18asthma29.6NOS2, CHKB, TNC, CIITA, IL12RB1
19systemic lupus erythematosus29.5CIITA, CD70, ICOS, IL10RA, IL12RB1, IL2
20multiple sclerosis29.3NOS2, TNC, IL2, CIITA, CD274
21melanoma28.4IL10RA, TNC, CIITA, TXN, CD70, CD274
22autoimmune myocarditis11.1
23giant cell myocarditis11.0
24rheumatic myocarditis10.6
25interstitial myocarditis10.6
26fiedler's myocarditis10.5
27infectious myocarditis10.5
28toxic myocarditis10.5
29periapical granuloma10.5NOS2
30influenza10.5
31atrioventricular block10.4
32pericarditis10.4
33thymoma10.4
34myositis10.4
35cardiogenic shock10.4
36pulmonary sarcoidosis10.3IL2, IL12RB1
37lupus erythematosus10.3
38toxic shock syndrome10.3CIITA, IL2
39pleomorphic adenoma10.3TNC, NOS2
40myopathy congenital10.3CHKB, MYH6
41pulmonary tuberculosis10.3IL2, IL12RB1
42churg-strauss syndrome10.3
43pneumonia10.3
44polymyositis10.3
45cork-handlers' disease10.3TNC, IL12RB1, TXN
46lymphopenia10.2IL2, CIITA
47trichinosis10.2
48colitis10.2
49eosinophilia10.2
50hepatitis c10.2TXN, CIITA, IL2

Graphical network of the top 20 diseases related to Myocarditis:



Diseases related to myocarditis

Symptoms for Myocarditis

About this section

Drugs & Therapeutics for Myocarditis

About this section

Drug clinical trials:

Search ClinicalTrials for Myocarditis

Search NIH Clinical Center for Myocarditis

Genetic Tests for Myocarditis

About this section

Anatomical Context for Myocarditis

About this section

MalaCards organs/tissues related to Myocarditis:

32
Heart, T cells, Monocytes, Tonsil, Bone, Liver, B cells, Cardiac myocytes, Brain, Thyroid, Bone marrow, Thymus, Skeletal muscle, Adipocyte, Kidney, Lung, Pancreas, Skin, Testes, Myeloid, Nk cells, Endothelial

Animal Models for Myocarditis or affiliated genes

About this section

MGI Mouse Phenotypes related to Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4ADRB1, ICOS, IL2, NOS2, CIITA
2MP:00053868.1TNC, MYH6, CHKB, IL2, NOS2, CD274
3MP:00053977.4CIITA, ICOS, IL2, IL12RB1, IL10RA, NOS2
4MP:00053877.3CIITA, ICOS, IL2, IL12RB1, IL10RA, NOS2
5MP:00053766.4CD274, TNC, CIITA, MYH6, ADRB1, CHKB

Publications for Myocarditis

About this section

Articles related to Myocarditis:

(show top 50)    (show all 1600)
idTitleAuthorsYear
1
Clinically manifested myocarditis in acute rheumatic fever. (24676379)
2014
2
A case of fetal parvovirus b19 myocarditis that caused terminal heart failure. (25328731)
2014
3
Formation of a fibrin net on the polypropylene membrane oxygenator used for percutaneous cardiopulmonary support in a patient with acute myocarditis. (24875892)
2014
4
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
5
Enteroviral myocarditis in neonates. (23711335)
2013
6
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
7
Thrombotic events in critically ill children with myocarditis. (24016733)
2013
8
Pericarditis, myocarditis, and other cardiomyopathies. (23402470)
2013
9
Fulminant human herpesvirus 6 myocarditis in an immunocompetent adult: role of cardiac magnetic resonance in a multidisciplinary approach. (24297820)
2013
10
Innate immune interleukin-1 receptor-associated kinase 4 exacerbates viral myocarditis by reducing CCR5(+) CD11b(+) monocyte migration and impairing interferon production. (24030499)
2013
11
Myocarditis: early biopsy allows for tailored regenerative treatment. (22685492)
2012
12
A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-I_B signaling. (23029542)
2012
13
Endocarditis and myocarditis: a brief review. (23098151)
2012
14
Autoimmunity against Ma88muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. (22328321)
2012
15
Pathogenesis of coxsackievirus B3-induced myocarditis: role of macrophage migration inhibitory factor. (22340465)
2012
16
PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis. (20356766)
2011
17
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
18
Dengue myositis and myocarditis. (20739801)
2010
19
Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis. (18329552)
2008
20
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. (17588693)
2008
21
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
22
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
23
Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. (16601447)
2006
24
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
25
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
26
Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome. (15837284)
2005
27
An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. (14613869)
2003
28
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
29
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
30
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
31
Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice. (9166288)
1997
32
Data on giant cell myocarditis sought for new study. (8616928)
1996
33
Announcement of multicenter giant-cell myocarditis study. (7677103)
1995
34
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
35
Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. (2396870)
1990
36
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
37
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
38
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
39
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
40
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985
41
A case of congestive cardiomyopathy with histological findings suggesting rheumatic myocarditis by endomyocardial biopsy. (6448932)
1980
42
Giant cell myocarditis. (6989338)
1980
43
A case of giant cell myocarditis. (4748147)
1973
44
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
45
Rheumatic myocarditis in an infant nine months of age. (5782817)
1969
46
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
47
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
48
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
49
Fiedler's myocarditis at age of two months. (13217368)
1954
50
Fulminating trichinosis with myocarditis. (13176789)
1954

Variations for Myocarditis

About this section

Expression for genes affiliated with Myocarditis

About this section
Expression patterns in normal tissues for genes affiliated with Myocarditis

Search GEO for disease gene expression data for Myocarditis.

Pathways for genes affiliated with Myocarditis

About this section

Pathways related to Myocarditis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOS2, CIITA
29.8ICOS, CIITA
39.8IL2, NOS2
4
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.6IL2, IL12RB1, NOS2
5
Show member pathways
Type III interferon signaling37
9.5IL12RB1, IL10RA, IL2
69.5CIITA, IL10RA, NOS2
7
Show member pathways
9.2IL2, IL12RB1, IL10RA, MYH6
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL2, IL12RB1, IL10RA, NOS2
99.0TXN, CIITA, IL2
10
Show member pathways
8.9IL2, CD70, IL10RA, IL12RB1
11
Show member pathways
8.9IL10RA, TNC, MYH6, IL2, IL12RB1
12
Show member pathways
8.9CIITA, NOS2, IL10RA, IL12RB1, IL2
13
Show member pathways
8.5IL10RA, IL12RB1, IL2, ICOS, MYH6, CIITA

Compounds for genes affiliated with Myocarditis

About this section

Compounds related to Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1toxin-14410.2CIITA, IL2
2glatiramer acetate44 1111.2IL2, CIITA
3taurine chloramine4410.2NOS2, IL2
4il-124410.2IL12RB1, IL2
5minocycline44 1111.2NOS2, CIITA
6nebivolol44 1111.1NOS2, ADRB1
7triptolide4410.0NOS2, IL2
8polyinosinic-polycytidylic acid4410.0NOS2, IL2, CIITA
9xamoterol44 2810.8CHKB, ADRB1
10dobutamine44 28 50 1112.8ADRB1, CHKB
11isoproterenol44 1110.7NOS2, ADRB1, MYH6
12fotemustine44 1110.7IL2, TXN
13ebselen449.7TXN, NOS2
14gold sodium thiomalate449.7IL2, TXN
15rosuvastatin44 50 28 1112.6NOS2, CHKB
16amiodarone44 50 28 1112.6ADRB1, CHKB
17auranofin28 44 61 1112.6TXN, IL2
18endotoxin449.6NOS2, CHKB, CIITA
19triiodothyronine449.5MYH6, ADRB1, CHKB
20rantes449.5CD70, IL2, CIITA
21guanidine44 24 1111.5CHKB, NOS2
22salbutamol44 50 28 24 1113.5ADRB1, CHKB
23cerivastatin50 44 28 1112.4CHKB, NOS2
24chloramphenicol44 2 50 1112.3MYH6, TXN, TNC
25pge2449.3NOS2, IL2, CHKB, CIITA
26ionomycin449.3IL2, IL12RB1, CD274, CD70
27gssg449.2TXN, CHKB
28carnitine449.2TXN, MYH6, CHKB
29isotretinoin44 1110.1IL2, CHKB, TXN
30peroxynitrite449.1TXN, CHKB, NOS2
31gsno449.0TXN, NOS2
32thyroxine44 249.9TXN, CIITA, MYH6, CHKB
33n acetylcysteine448.9TXN, CHKB, NOS2
34actinomycin d448.9TNC, TXN, CIITA, IL2, NOS2
35ascorbic acid44 249.8NOS2, CHKB, TXN, TNC
36cycloheximide448.8TNC, TXN, CIITA, IL2, NOS2
37tyrosine448.8TNC, CIITA, ADRB1, IL2, IL12RB1, IL10RA
38cyclosporin a44 28 6110.8TXN, CIITA, CHKB, IL2
39h2o2448.7TNC, TXN, CHKB, NOS2
40nitric oxide44 24 1110.7CIITA, ADRB1, CHKB, NOS2, CD274
41adenylate448.6TXN, ADRB1, CHKB, NOS2
42estrogen448.5TNC, TXN, MYH6, CHKB, NOS2
43calcium44 50 24 1111.5TNC, CIITA, MYH6, ADRB1, CHKB, NOS2
44vegf448.5TNC, TXN, CHKB, IL2, NOS2
45arginine448.4TXN, MYH6, ADRB1, CHKB, NOS2
46glutamate448.4TNC, TXN, ADRB1, CHKB, NOS2
47alanine448.3CHKB, ADRB1, CIITA, TXN
48oxygen44 249.1TXN, CIITA, MYH6, ADRB1, CHKB, NOS2
49serine448.0TNC, TXN, CIITA, MYH6, ADRB1, IL2
50dexamethasone44 50 28 1110.0CD274, TNC, TXN, CIITA, ADRB1, CHKB

GO Terms for genes affiliated with Myocarditis

About this section

Cellular components related to Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CD274, IL12RB1, ICOS

Biological processes related to Myocarditis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.9IL2, IL12RB1
2cellular response to interferon-gammaGO:0713469.9NOS2, IL12RB1
3positive regulation of interferon-gamma productionGO:0327299.9IL12RB1, IL2
4cytokine-mediated signaling pathwayGO:0192219.4CIITA, IL12RB1, IL10RA
5immune responseGO:0069558.6CD70, CD274, IL2, ICOS, CIITA
6cell-cell signalingGO:0072678.5CD70, IL2, TXN
7signal transductionGO:0071658.1TXN, IL12RB1, IL10RA, CD274, CD70

Products for genes affiliated with Myocarditis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Myocarditis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet