Myoclonus malady

NINDS: Myoclonus refers to a sudden, involuntary jerking of a muscle or group of muscles. In its simplest form, myoclonus consists of a muscle twitch followed by relaxation. A hiccup is an example of this type of myoclonus. Other familiar examples of myoclonus are the jerks or "sleep starts" that some people experience while drifting off to sleep.³¹

MalaCards: Myoclonus is related to progressive myoclonus epilepsy and myoclonus-dystonia. An important gene associated with Myoclonus is EPM2A (epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)), and among its related pathways are Glycogen metabolism and Lysosome. The compounds aspartate and rotigotine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and breast, and related mouse phenotypes are liver/biliary system and adipose tissue.

Wikipedia: Myoclonus (pron.: /maɪˈɒklənəs/) is a brief, involuntary twitching of a muscle or a group of...⁴⁴ more...

myoclonus 31

Diseases related to myoclonus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 262)

id	Related Disease	Score	Top Affiliating Genes
1	progressive myoclonus epilepsy	36.1	TRAPPC10, PWP2, PRICKLE1
2	myoclonus-dystonia	35.8	SGCE, TOR1A
3	myoclonus epilepsy	33.2	SERPINI1, CLN5, CLN3, PARK2, SDHB, SCARB2
4	lafora disease	32.2	NHLRC1, EPM2A
5	unverricht-lundborg syndrome	32.2	PRICKLE1, CSTB
6	dancing eyes-dancing feet syndrome	31.3	GPI, AMPH, TNFSF13, TNFSF13B, NOVA1, POMC
7	merrf syndrome	30.7	SDHB, MT-ND5, MT-TK, COX5A
8	myoclonic cerebellar dyssynergia	30.0	CTSA, NOVA1
9	mitochondrial encephalomyopathy	27.4	MT-ND5, MT-CO2, COX5A
10	benign hereditary chorea	27.4	SGCE, HTT, NKX2-1
11	brain ischemia	27.0	CDKN3, ALDOA, DUSP19, CTSB, ACP1, GFAP
12	cramps	27.0	SGCE, PARK2, INS, TOR1A, GBA
13	status epilepticus	26.9	SERPINI1, ATN1, GFAP, POLG, NHLRC1, GABBR1
14	chorea	26.7	SGCE, ATN1, HTT, GFAP, TOR1A, NKX2-1
15	gaucher's disease	26.5	PARK2, SCARB2, UBC, CTSB, SNCA, GBA
16	convulsions	26.4	GCH1, SDHB, SCN2A, ACP1, PSEN1, CSTB
17	tourette syndrome	25.6	SGCE, GCH1, HTR1A, HTR2A, HTR2C, DRD2
18	cerebellar ataxia	25.4	SCASI, ATXN2, ATN1, INS, MAG, HTT
19	polyneuropathy	25.3	INS, MAG, IFNA2, AMPH, POLG, AAAS
20	huntington's disease	25.3	SERPINI1, SDHB, ATN1, HTT, DRD2, SNCA
21	peripheral neuropathy	25.2	SCARB2, SCN2A, ATXN2, INS, MAG, COX5A
22	obsessive-compulsive disorder	25.1	SGCE, AMPH, HTR1A, HTR1D, HTR2A, HTR2C
23	twinning	24.7	SGCE, ATN1, GYS1, INS, GSK3B, MECP2
24	epilepsy syndrome	24.5	SGCE, SERPINI1, CLN5, ATXN2, CDKN3, MECP2
25	alcoholism	24.3	HTR1A, HTR2A, HTR2C, DRD2, DRD3, DRD4
26	alcohol dependence	24.3	SGCE, HTR1A, HTR2A, HTR2C, DRD2, DRD3
27	ataxia	23.6	SGCE, SERPINI1, SCN2A, SCASI, UBC, MT-TK
28	tremor	23.5	SGCE, PARK2, ATXN2, CDKN3, FCMTE2, IFNA2
29	seizures	23.2	SERPINI1, CLN5, CLN3, PARK2, SDHB, SCN2A
30	neuropathy	22.4	PARK2, SCARB2, SCN2A, SCASI, MT-ND5, ATXN2
31	breast carcinoma	22.0	CDKN3, INS, APC, GPI, IFNA2, AMPH
32	hepatitis	20.0	SDHB, SCARB2, UBC, MT-CO2, CDKN3, GYS1
33	ischemia	19.9	SERPINI1, PARK2, SDHB, UBC, CDKN3, INS
34	dementia	19.9	SERPINI1, CLN5, CLN3, PARK2, SDHB, SCARB2
35	alzheimer's disease	19.0	SERPINI1, PARK2, SDHB, UBC, MT-CO2, ATXN2
36	carcinoma	18.5	SGCE, PARK2, SDHB, UBC, MT-ND5, MT-CO2
37	neuronitis	15.3	GCH1, SERPINI1, CLN5, CLN3, PARK2, SDHB
38	focal dystonia	13.8	SGCE, PARK2, DRD2, TOR1A
39	early-onset primary dystonia (dyt1)	13.8	SGCE, GCH1, TOR1A
40	neuronal ceroid-lipofuscinoses	13.7	CLN5, CLN3, TPP1
41	multiple symmetric lipomatosis	13.7	SDHB, COX5A, ACP1
42	hydrops fetalis	13.7	GPI, NEU1, GBA, GBE1
43	lysosomal storage disease	13.6	CLN3, TPP1, CTSA, CTSB, NEU1, GBA
44	manic-depressive illness	13.6	GSK3B, DRD2, DRD3, DRD4
45	personality disorder	13.6	DRD2, DRD3, DRD4
46	cerebral atrophy	13.5	CLN5, CLN3, TPP1, GFAP
47	complex regional pain syndrome	13.5	SGCE, GCH1, CDKN3, DRD2, GFAP
48	neuronal ceroid-lipofuscinosis	13.5	CLN5, CLN3, TPP1, CTSB
49	kearns-sayre syndrome	13.4	MT-ND5, MT-CO2, COX5A
50	ceroid lipofuscinosis	13.4	CLN5, CLN3, TPP1, CTSB, GFAP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myoclonus:

²²

MGI Mouse Phenotypes related to myoclonus:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.2	GBE1, GBA, EPM2A, NHLRC1, INS, CTSA
2	adipose tissue phenotype	MP:0005375	8.4	HTR2C, DRD2, DRD3, EIF2B5, MECP2, EPM2A
3	endocrine/exocrine gland phenotype	MP:0005379	8.3	HTR2A, TPP1, PSEN1, HTT, NKX2-1, WFS1
4	muscle phenotype	MP:0005369	8.1	GFAP, PSEN1, CSTB, POLG, NHLRC1, DRD2
5	skeleton phenotype	MP:0005390	8.0	PARK2, INS, APC, HTT, DRD2, SNCA
6	renal/urinary system phenotype	MP:0005367	7.8	PSEN1, POMC, SLC22A2, NEU1, SNCA, CTSB
7	no phenotypic analysis	MP:0003012	7.7	APC, MECP2, INS, CLN3, ATN1, GPI
8	digestive/alimentary phenotype	MP:0005381	6.7	GSK3B, APC, HTR2A, TPP1, DRD2, DRD3
9	cardiovascular system phenotype	MP:0005385	6.7	CTSA, SNCA, GFAP, PSEN1, NKX2-1, POLG
10	integument phenotype	MP:0010771	6.7	HTT, HTR2C, APC, MECP2, INS, PARK2
11	cellular phenotype	MP:0005384	6.3	HTT, TNFSF13, TNFSF13B, DRD2, CTSA, CTSB
12	growth/size phenotype	MP:0005378	5.2	DRD3, DRD2, HTT, HTR2C, PARK2, GPI
13	nervous system phenotype	MP:0003631	5.2	DRD2, TPP1, HTT, HTR2C, HTR1A, AMPH
14	mortality/aging	MP:0010768	4.7	CLN3, AMPH, HTR1A, HTR2C, HTT, TPP1
15	homeostasis/metabolism phenotype	MP:0005376	4.6	TPP1, EIF2B5, HTT, DRD2, DRD3, DRD4
16	behavior/neurological phenotype	MP:0005386	3.8	CSTB, PRICKLE1, POMC, PSEN1, TOR1A, ATXN2

Articles related to myoclonus:

(show top 50)    (show all 159)

id	Title	Authors	Year	Affiliating Genes
1	Familial 7q21.3 microdeletion involving epsilon-sarco glycan causing myoclonus dystonia, cognitive impairment, and psychosis. (21425342)	Dale R.C.... Peters G.B.	2011	SGCE
2	SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain. (20956790)	Liao Y.... Lehesjoki A.E.	2010	SCN2A
3	Myoclonus dystonia plus syndrome due to a novel 7q21 microdeletion. (20425829)	Saugier-Veber P.... Roze E.	2010	SGCE
4	Myoclonus-dystonia and spinocerebellar ataxia type 14 presenting with similar phenotypes: trunk tremor, myoclonus, and dystonia. (19913450)	Foncke E.M.... Tijssen M.A.	2010	SGCE
5	Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. (19147686)	Suzuki T.... Yamakawa K.	2009	EFHC1
6	A longitudinal study of Taiwanese sialidosis type 1: an insight into the concept of cherry-red spot myoclonus syndrome. (19473359)	Lai S.C.... Lu C.S.	2009	NEU1
7	Myoclonus in fraternal twin toddlers: a French family with a novel mutation in the SGCE gene. (19147379)	ThA1mmler S.... Perelman S.	2009	SGCE
8	Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus? (18824390)	Puschmann A.... Nilsson C.	2009	SNCA, CSTB
9	Leucoencephalopathy with vanishing white matter may cause progressive myoclonus epilepsy. (18266750)	Jansen A.C.... Andermann F.	2008	EIF2B5
10	Cortical excitability in DYT-11 positive myoclonus dystonia. (18265016)	.... Trocello J.M.	2008	SGCE
11	Lafora progressive myoclonus epilepsy: disease course homogeneity in a genetic isolate. (18263761)	Turnbull J.... Minassian B.A.	2008	NHLRC1
12	Myoclonus-Dystonia: clinical and genetic evaluation of a large cohort. (19066193)	Ritz K.... Tijssen M.A.	2008	SGCE, TOR1A
13	A neurophysiological study of myoclonus in patients with DYT11 myoclonus-dystonia syndrome. (18759336)	Marelli C.... Franceschetti S.	2008	SGCE
14	Modulation of functional properties of laforin phosphatase by alternative splicing reveals a novel mechanism for the EPM2A gene in Lafora progressive myoclonus epilepsy. (18617530)	Dubey D.... Ganesh S.	2008	EPM2A, NHLRC1
15	Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers. (17296918)	Hess C.W.... Saunders-Pullman R.	2007	SGCE
16	Novel human pathological mutations. Gene symbol: EPM2A. Disease: Lafora progressive myoclonus epilepsy. (17879451)	Trujillo-Tiebas M.J.... Ayuso Garcia C.	2007	EPM2A
17	Clinical differentiation of genetically proven benign hereditary chorea and myoclonus-dystonia. (17702043)	Asmus F.... Chinnery P.F.	2007	SGCE, NKX2-1
18	Novel and de novo mutations of the SGCE gene in Brazilian patients with myoclonus-dystonia. (17394244)	Borges V.... Ozelius L.J.	2007	SGCE
19	Phenotype-genotype correlation in Dutch patients with myoclonus-dystonia. (16534121)	Gerrits M.C.... Tijssen M.A.	2006	SGCE
20	Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. (16543530)	Candler P.M.... Rees J.H.	2006	GPI
21	Progressive myoclonus epilepsies: EPM1, EPM2A, EPM2B. (15508913)	Chan E.M.... Minassian B.	2005	NHLRC1
22	Lafora progressive Myoclonus Epilepsy mutation database-EPM2A and NHLRC1 (EPM2B) genes. (16134145)	Ianzano L.... Minassian B.A.	2005	ACP1, EPM2A, NHLRC1
23	Myoclonus-dystonia: detection of novel, recurrent, and de novo SGCE mutations. (15079037)	Hedrich K.... Klein C.	2004	SGCE
24	Progressive myoclonus epilepsy with polyglucosans (Lafora disease): evidence for a third locus. (15304597)	Chan E.M.... Minassian B.A.	2004	NHLRC1
25	Loss of function of the cytoplasmic isoform of the protein laforin (EPM2A) causes Lafora progressive myoclonus epilepsy. (14722920)	Ianzano L.... Minassian B.A.	2004	EPM2A
26	Early-onset encephalopathy and cortical myoclonus in a boy with MECP2 gene mutation. (15557528)	Leuzzi V.... Seri S.	2004	MECP2
27	A novel mutation (L250V) in the presenilin 1 gene in a Japanese familial Alzheimer's disease with myoclonus and generalized convulsion. (12686406)	Furuya H.... Ohyagi Y.	2003	PSEN1
28	Molecular background of progressive myoclonus epilepsy. (12853462)	Lehesjoki A.E.	2003	CSTB
29	A form of inherited cerebellar ataxia with saccadic intrusions, increased saccadic speed, sensory neuropathy, and myoclonus. (11960835)	Swartz B.E.... Leigh R.J.	2002	SCASI
30	Evidence that paternal expression of the epsilon-sarcoglycan gene accounts for reduced penetrance in myoclonus-dystonia. (12444570)	Muller B.... Klein C.	2002	SGCE
31	Progressive myoclonus epilepsy [EPM1] repeat d(CCCCGCCCCGCG)n forms folded hairpin structures at physiological pH. (11697734)	Pataskar S.S.... Brahmachari S.K.	2001	CSTB
32	Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. (11157570)	Bataller L.... Vilchez J.J.	2001	AMPH
33	Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1). (11139332)	Riccio M.... Santi S.	2001	CTSB, CSTB
34	Mutational spectrum of the EPM2A gene in progressive myoclonus epilepsy of Lafora: high degree of allelic heterogeneity and prevalence of deletions. (11175283)	Gomez-Garre P.... Serratosa J.M.	2000	EPM2A
35	Immunohistochemical demonstration of spinal ventral horn cells involvement in a case of 'myoclonus epilepsy with ragged red fibers' (MERRF). (10919352)	Sparaco M.... Rizzuto N.	2000	MT-CO2
36	Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy. (11138927)	Takao M.... Ghetti B.	2000	SERPINI1
37	Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes. (11001928)	Ganesh S.... Yamakawa K.	2000	EPM2A, CDKN3, DUSP13
38	Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (10220438)	Klein C.... Ozelius L.J.	1999	DRD2
39	A case of stiff-man syndrome with head retraction li ke reflex myoclonus and jerky myoclonus of bilateral lower extremities which re sponded well to removal of mediastinal carcinoma (10655763)	Harada H.... Shoji S.	1999	AMPH
40	Unstable insertion in the 5' flanking region of the cystatin B gene is the most common mutation in progressive myoclonus epilepsy type 1, EPM1. (9054946)	Lafreniere R.G.... Rouleau G.A.	1997	CSTB
41	Lafora progressive myoclonus epilepsy: narrowing the chromosome 6q24 locus by recombinations and homozygosities. (9345091)	Sainz J.... Delgado-Escueta A.V.	1997	EPM2A
42	Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1. (9090386)	Virtaneva K.... Lehesjoki A.E.	1997	CSTB
43	Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1). (8596935)	Pennacchio L.A.... Myers R.M.	1996	CSTB
44	Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. (7633421)	Yamakawa K.... Korenberg J.R.	1995	TRAPPC10
45	Nocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration. (7786913)	Staedt J.... RA1ther E.	1995	DRD2
46	Single photon emission tomography (SPET) imaging of dopamine D2 receptors in the course of dopamine replacement therapy in patients with nocturnal myoclonus syndrome (NMS). (8579804)	Staedt J.... RA1ther E.	1995	DRD2
47	Nightly myoclonus syndrome (NMS) and restless legs s yndrome (RLS)--review and case report (8181789)	Staedt J.... RA1ther E.	1994	DRD2
48	Progressive Myoclonus Epilepsy, Lafora Type (20301563)	Jansen A.C.... Andermann E.	1993	EPM2A, NHLRC1
49	Myoclonus-Dystonia (20301587)	Raymond D.... Ozelius L.	1993	DRD2, SGCE
50	Localization of a gene for progressive myoclonus epil epsy to chromosome 21q22. (1673790)	Lehesjoki A.E.... de la Chapelle A.	1991	EMP1

Genes related to myoclonus according to GeneCards:

(show top 50)    (show all 80)

id	Symbol	Description	Score	GeneCards Section Context
1	EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	11.1	Publications, Transcripts, Aliases & Descriptions, Orthologs
2	PRICKLE1	prickle homolog 1 (Drosophila)	11.1	Publications, Summaries
3	SCARB2	scavenger receptor class B, member 2	11.1	Summaries, Publications
4	EPM2AIP1	EPM2A (laforin) interacting protein 1	11.1	Summaries, Publications
5	TRAPPC10	trafficking protein particle complex 10	11.1	Publications, Summaries
6	SGCE	sarcoglycan, epsilon	11.1	Summaries, Publications
7	DRD2	dopamine receptor D2	11.1	Orthologs, Summaries, Publications
8	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Summaries, Publications
9	NHLRC1	NHL repeat containing 1	11.0	Publications
10	CSTB	cystatin B (stefin B)	11.0	Publications
11	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	11.0	Publications
12	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
13	UBC	ubiquitin C	11.0	Publications
14	CLN5	ceroid-lipofuscinosis, neuronal 5	11.0	Publications
15	TPP1	tripeptidyl peptidase I	11.0	Publications
16	EIF2B5	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	11.0	Publications
17	PWP2	PWP2 periodic tryptophan protein homolog (yeast)	11.0	Publications
18	DUSP13	dual specificity phosphatase 13	11.0	Publications
19	EMP2	epithelial membrane protein 2	11.0	Publications
20	GYS1	glycogen synthase 1 (muscle)	11.0	Publications
21	CLN3	ceroid-lipofuscinosis, neuronal 3	11.0	Publications
22	NOVA1	neuro-oncological ventral antigen 1	11.0	Functions, Publications
23	U2AF1	U2 small nuclear RNA auxiliary factor 1	11.0	Publications
24	ACP1	acid phosphatase 1, soluble	11.0	Publications
25	GBE1	glucan (1,4-alpha-), branching enzyme 1	11.0	Publications
26	GBA	glucosidase, beta, acid	11.0	Publications
27	U2AF2	U2 small nuclear RNA auxiliary factor 2	11.0	Publications
28	DUSP19	dual specificity phosphatase 19	11.0	Publications
29	POMC	proopiomelanocortin	11.0	Publications
30	APC	adenomatous polyposis coli	11.0	Publications
31	GSK3B	glycogen synthase kinase 3 beta	11.0	Publications
32	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications
33	DYT15	dystonia 15, myoclonic	11.0	Publications
34	FCMTE2	familial cortical myoclonic tremor with epilepsy 2	11.0	Publications
35	MT-TK	mitochondrially encoded tRNA lysine	11.0	Publications
36	TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	11.0	Orthologs
37	GOSR2	golgi SNAP receptor complex member 2	11.0	Publications
38	TOR1A	torsin family 1, member A (torsin A)	11.0	Publications
39	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	11.0	Publications
40	CASD1	CAS1 domain containing 1	11.0	Publications
41	CTSA	cathepsin A	11.0
42	ATN1	atrophin 1	11.0	Publications
43	NKX2-1	NK2 homeobox 1	11.0	Publications
44	GCH1	GTP cyclohydrolase 1	11.0	Publications
45	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
46	GPI	glucose-6-phosphate isomerase	11.0	Publications
47	AMPH	amphiphysin	11.0	Publications
48	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
49	DRD3	dopamine receptor D3	11.0	Orthologs
50	CTSB	cathepsin B	11.0	Publications

Pathways related to myoclonus according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Glycogen metabolism10	10.3	GBE1, GPI, GYS1
2	Lysosome20	10.2	CTSA, TPP1, SCARB2, CLN3, CLN5, CTSB
3	Glycogen metabolism41	10.0	GBE1, GYS1, GPI
4	Parkinsons disease20	9.0	PARK2, COX5A, SNCA, MT-CO2, MT-ND5, SDHB
5	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.0	HTR2A, HTR1D, HTR1A, HTR2C
6	Amine ligand-binding receptors38	8.8	DRD2, HTR1A, HTR1D, HTR2A, HTR2C, DRD3
7	Alzheimers disease20	8.7	SNCA, GSK3B, MT-CO2, SDHB, COX5A, PSEN1
8	Neuroactive ligand-receptor interaction20	8.5	HTR2C, GABBR1, DRD4, DRD3, DRD2, HTR2A
9	Neuroscience3	7.4	GSK3B, GABBR1, WFS1, PSEN1, GFAP, SNCA

Compounds related to myoclonus according to GeneDecks:

(show top 50)    (show all 194)

id	Compound	Score	Top Affiliating Genes
1	aspartate32	9.8	TPP1, GFAP, DUSP19, SDHB, POMC, GPI
2	rotigotine32 9 9	11.7	DRD2, HTR1A, DRD3, DRD4, CYP2D6
3	remoxipride32 9 9	11.7	DRD2, CYP2D6, HTR2A, DRD4, DRD3
4	epinephrine32 9 18 9	12.4	GCH1, SDHB, GYS1, SLC22A2, POMC, DRD4
5	raclopride32 42	10.3	HTR1A, DRD2, DRD3, DRD4, HTR2A
6	glucose32	9.3	GCH1, GPI, IFNA2, ALDOA, APC, GABBR1
7	piperazine32 9 9	11.3	HTR2A, HTR1A, CYP2D6, DRD4, DRD3, DRD2
8	Methotrimeprazine9 9	10.3	DRD4, DRD3, DRD2, HTR2C, HTR2A, CYP2D6
9	maoa32	9.2	HTR1A, HTR2C, DRD4, DRD2, HTR2A, POMC
10	ritanserin32	9.2	HTR2A, HTR1D, DRD2, HTR2C, HTR1A
11	haloperidol32 34 9 9	12.1	DRD4, DRD3, HTR2A, HTR1A
12	Pipotiazine9 9	10.1	CYP2D6, CYP2C19, DRD2, HTR1A, HTR2A
13	levodopa32 9 9	11.1	DRD3, DUSP19, SNCA, GCH1, CDKN3, HTR1A
14	ipsapirone32	9.1	HTR2C, POMC, HTR1A, HTR1D, HTR2A
15	starch32	9.1	GBE1, INS, GPI, ACP1, EPM2A, IFNA2
16	cabergoline32 9 9	11.0	HTR1D, HTR1A, HTR2A, HTR2C, DRD3, DRD2
17	clozapine32 34 9 9	11.9	HTR2C, DRD3, DRD2, POMC, HTR2A, HTR1D
18	catecholamine32	8.9	PARK2, GABBR1, DRD4, SNCA, POMC, SLC22A2
19	bromocriptine32 9 9	10.9	HTR1D, DRD4, HTR2A, HTR2C, DRD2, DRD3
20	methamphetamine32 9 9	10.9	DRD3, COX5A, SNCA, CYP2D6, DRD4, DRD2
21	yohimbine32 9 9	10.8	HTR2C, DRD2, DRD3, CYP2D6, HTR2A, HTR1A
22	pramipexole32 9 9	10.8	SLC22A2, DRD4, DRD3, DRD2, HTR2C, HTR2A
23	sertindole32 9 9	10.8	HTR1A, CYP2D6, DRD2, HTR2C, HTR2A
24	lisuride32 9 9	10.8	DRD3, DRD2, HTR1D, HTR1A, CYP2D6, DRD4
25	ropinirole32 9 9	10.8	HTR2C, HTR2A, HTR1A, DRD3, DRD4, CYP2D6
26	pergolide32 9 9	10.7	CYP2D6, HTR1A, HTR1D, HTR2A, HTR2C, DRD2
27	aripiprazole32 34 9 18 9	12.7	DRD2, HTR1A, CYP2D6, DRD4, HTR2C, DRD3
28	ziprasidone32 9 9	10.7	HTR1D, HTR2A, HTR2C, DRD4, DRD3, DRD2
29	mptp32	8.6	ACP1, GFAP, SNCA, DRD3, DRD2, PARK2
30	doxepin32 34 9 9	11.6	CYP2D6, CYP2C19, DRD2, HTR2C, HTR2A, HTR1A
31	cocaine32 9 9	10.5	HTR2C, CDKN3, CYP2D6, SNCA, DRD4, GABBR1
32	paliperidone32 9 9	10.5	HTR2A, HTR1A, HTR1D, HTR2C, DRD2, DRD3
33	risperidone32 34 9 18 9	12.4	DRD2, HTR1D, HTR2A, HTR2C, DRD3, DRD4
34	quetiapine32 9 18 9	11.4	CYP2D6, DRD2, DRD3, CYP2C19, DRD4, HTR1A
35	5-hydroxytryptamine32	8.2	DRD2, SLC22A2, POMC, GFAP, DRD4, HTR2C
36	apomorphine32 9 9	10.2	HTR1A, DRD2, SNCA, HTR1D, HTR2C, DRD3
37	nmda32 42	9.1	GABBR1, PSEN1, DRD3, HTT, GFAP, ACP1
38	olanzapine32 34 9 18 9	11.9	INS, HTR1A, HTR1D, HTR2C, HTR2A, DRD2
39	glycogen32 18	8.6	INS, SDHB, CDKN3, GYS1, PARK2, GSK3B
40	alanine32	7.6	IFNA2, MAG, CTSB, ACP1, TNFSF13B, HTT
41	acetylcholine32 9 18 9	10.5	DUSP19, DRD2, CYP2D6, SNCA, NEU1, SLC22A2
42	adenylate32	7.4	POLG, POMC, GBA, GABBR1, HTR1D, GFAP
43	dopamine32 9 18 9	10.0	DRD4, DRD3, DRD2, DUSP19, HTT, HTR2C
44	glutamate32	6.9	DRD4, DRD2, DUSP19, HTT, HTR2C, CTSB
45	cysteine32	6.7	HTR2C, IFNA2, SDHB, MAG, ATN1, GABBR1
46	norepinephrine32 9 18 9	9.5	DRD3, HTR2C, HTR2A, HTR1D, HTR1A, APC
47	calcium32 9 18 9	9.4	HTR2C, SDHB, EFHC1, MAG, EPM2A, GBA
48	serine32	6.1	ACP1, DRD4, HTR2C, DRD3, DUSP19, DUSP13
49	lipid32	5.6	PARK2, HTR2C, AMPH, IFNA2, GPI, MAG
50	tyrosine32	4.6	GPI, IFNA2, HTR2C, HTT, ALDOA, TRAPPC10

Cellular components related to myoclonus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lysosomal lumen	GO:043202	10.1	SCARB2, TPP1, CTSA, NEU1, GBA
2	lysosome	GO:005764	10.1	CLN3, TPP1, CTSA, CTSB, NEU1, CLN5
3	inclusion body	GO:016234	8.9	GYS1, HTT, SNCA
4	endoplasmic reticulum	GO:005783	8.8	PSEN1, NHLRC1, EPM2A, TOR1A, CTSA, CYP2D6

Biological processes related to myoclonus according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to histamine	GO:034776	10.5	DRD4, DRD2, DRD3
2	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.4	DRD3, DRD4, DRD2
3	behavioral response to cocaine	GO:048148	10.4	DRD4, DRD3, DRD2
4	dopamine metabolic process	GO:042417	10.3	DRD2, DRD3, DRD4
5	negative regulation of adenylate cyclase activity	GO:007194	10.2	DRD2, DRD3, DRD4, GABBR1
6	synaptic transmission, dopaminergic	GO:001963	10.2	DRD3, DRD4, DRD2
7	locomotory behavior	GO:007626	10.0	NKX2-1, DRD3, DRD2, HTT, NOVA1
8	negative regulation of protein secretion	GO:050709	10.0	DRD2, INS, DRD4, DRD3
9	arachidonic acid secretion	GO:050482	9.9	DRD4, DRD3, DRD2
10	visual learning	GO:008542	9.9	MECP2, HTT, DRD2, DRD3
11	social behavior	GO:035176	9.7	DRD3, MECP2, HTT, DRD4
12	cell death	GO:008219	9.5	CLN3, PARK2, ATXN2, HTR2A, POLG, GBA
13	regulation of glutamate secretion	GO:014048	9.4	GABBR1, SNCA
14	adult locomotory behavior	GO:008344	9.3	MECP2, DRD4, SNCA, CSTB
15	regulation of dopamine secretion	GO:014059	9.3	HTR2A, DRD2, SNCA, DRD3
16	long-term synaptic potentiation	GO:060291	9.0	MECP2, SNCA, GFAP
17	negative regulation of neuron apoptotic process	GO:043524	8.5	SNCA, CLN3, MECP2, GPI, HTT, PSEN1
18	small molecule metabolic process	GO:044281	8.2	POMC, GYS1, INS, GPI, ALDOA, SLC22A2

Molecular functions related to myoclonus according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.2	DRD2, DRD4, DRD3
2	dopamine binding	GO:035240	9.9	DRD4, DRD3, DRD2
3	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO:071886	9.5	HTR2A, HTR2C
4	serotonin binding	GO:051378	9.0	HTR2C, HTR1A, HTR1D, HTR2A
5	serotonin receptor activity	GO:004993	9.0	HTR1A, HTR1D, HTR2C, HTR2A
6	drug binding	GO:008144	8.7	HTR2C, DRD3, DRD4, CYP2D6, DRD2, HTR1A
7	protein binding	GO:005515	4.9	CTSB, SNCA, EIF2B5, ACP1, PSEN1, PRICKLE1