Aliases & Classifications for Myoclonus

MalaCards integrated aliases for Myoclonus:

Name: Myoclonus 50 28

Classifications:



External Ids:

ICD10 32 G25.3

Summaries for Myoclonus

NINDS : 50 Myoclonus refers to a sudden, involuntary jerking of a muscle or group of muscles. In its simplest form, myoclonus consists of a muscle twitch followed by relaxation. A hiccup is an example of this type of myoclonus. Other familiar examples of myoclonus are the jerks or "sleep starts" that some people experience while drifting off to sleep.  These simple forms of myoclonus occur in normal, healthy persons and cause no difficulties. When more widespread, myoclonus may involve persistent, shock-like contractions in a group of muscles.  Myoclonic jerking may develop in people with multiple sclerosis, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jakob disease. Myoclonic jerks commonly occur in persons with epilepsy, a disorder in which the electrical activity in the brain becomes disordered and leads to seizures.  Myoclonus may develop in response to infection, head or spinal cord injury, stroke, brain tumors, kidney or liver failure, lipid storage disease, chemical or drug poisoning, or other disorders.  It can occur by itself, but most often it is one of several symptoms  associated with a wide variety of nervous system disorders.

MalaCards based summary : Myoclonus is related to progressive myoclonus epilepsy, lafora type and dystonia 11, myoclonic. An important gene associated with Myoclonus is SLC2A1 (Solute Carrier Family 2 Member 1). The drugs Midazolam and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and kidney, and related phenotypes are behavior/neurological and cellular

Related Diseases for Myoclonus

Diseases related to Myoclonus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 progressive myoclonus epilepsy, lafora type 33.1 EPM2A NHLRC1
2 dystonia 11, myoclonic 33.1 SGCE SLC2A1
3 myoclonic epilepsy of unverricht and lundborg 32.4 CSTB EPM2A
4 myoclonic epilepsy of lafora 31.9 CSTB EPM2A NHLRC1
5 progressive myoclonus epilepsy 31.3 CSTB EPM2A KCTD7 NHLRC1 PRICKLE1 SCARB2
6 early myoclonic encephalopathy 31.1 CSTB EPM2A
7 unverricht-lundborg syndrome 31.0 CSTB EPM2A NHLRC1 PRICKLE1 SCARB2
8 myoclonus epilepsy 30.9 CERS1 CSTB EPM2A NHLRC1 PRICKLE1 SCARB2
9 epilepsy 27.9 CERS1 CSTB EPM2A KCTD7 NHLRC1 PRICKLE1
10 opsoclonus-myoclonus syndrome 12.5
11 myoclonus, familial cortical 12.4
12 prickle1-related progressive myoclonus epilepsy with ataxia 12.2
13 propriospinal myoclonus 12.1
14 myoclonus, cerebellar ataxia, and deafness 12.1
15 myoclonus, intractable, neonatal 12.1
16 gosr2-related progressive myoclonus ataxia 12.0
17 myoclonus and ataxia 12.0
18 progressive encephalomyelitis with rigidity and myoclonus 11.9
19 epilepsy, progressive myoclonic, 4, with or without renal failure 11.9
20 myoclonus epilepsy partial seizure 11.8
21 branchial myoclonus with spastic paraparesis and cerebellar ataxia 11.8
22 neuraminidase deficiency 11.8
23 spinal muscular atrophy with progressive myoclonic epilepsy 11.7
24 epilepsy, progressive myoclonic, 6 11.7
25 myoclonic epilepsy associated with ragged-red fibers 11.7
26 epilepsy, progressive myoclonic 7 11.7
27 epileptic encephalopathy, early infantile, 6 11.6
28 epilepsy, progressive myoclonic, 1b 11.5
29 epilepsy, idiopathic generalized 10 11.5
30 periodic limb movement disorder 11.5
31 epilepsy, familial adult myoclonic, 2 11.5
32 myoclonic cerebellar dyssynergia 11.4
33 parasomnia, sleep bruxism type 11.3
34 epilepsy, progressive myoclonic, 8 11.3
35 epilepsy, progressive myoclonic, 9 11.3
36 galactosialidosis 11.2
37 dentatorubral-pallidoluysian atrophy 11.2
38 chorea, benign hereditary 11.2
39 psychogenic movement 11.2
40 geniospasm 1 11.1
41 corticobasal degeneration 11.1
42 stiff-person syndrome 11.1
43 creutzfeldt-jakob disease 11.0
44 mitochondrial myopathy 11.0
45 ataxia-telangiectasia 11.0
46 immunodeficiency 23 11.0
47 ceroid lipofuscinosis, neuronal, 7 10.9
48 myoclonic encephalopathy of infants 10.9
49 epilepsy, progressive myoclonic, 10 10.9
50 epilepsy, familial adult myoclonic, 1 10.9

Graphical network of the top 20 diseases related to Myoclonus:



Diseases related to Myoclonus

Symptoms & Phenotypes for Myoclonus

MGI Mouse Phenotypes related to Myoclonus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 SLC2A1 CERS1 CSTB EPM2A NEU1 NHLRC1
2 cellular MP:0005384 9.91 CERS1 CSTB EPM2A NEU1 NHLRC1 NOL3
3 cardiovascular system MP:0005385 9.8 SGCE EPM2A NEU1 NOL3 PRICKLE1 SCARB2
4 muscle MP:0005369 9.7 CSTB EPM2A NEU1 NHLRC1 NOL3 PRICKLE1
5 nervous system MP:0003631 9.61 CERS1 CSTB EPM2A NEU1 NHLRC1 PRICKLE1
6 no phenotypic analysis MP:0003012 9.02 CSTB NEU1 NHLRC1 PRICKLE1 SLC2A1

Drugs & Therapeutics for Myoclonus

Drugs for Myoclonus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
4
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6 Cisatracurium Approved, Experimental Phase 4 96946-41-7
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
10
Etomidate Approved Phase 4 33125-97-2 667484 36339
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
13
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
14
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
15
Atracurium Phase 4 64228-79-1 47319
16 Analgesics Phase 4,Phase 2
17 Central Nervous System Depressants Phase 4,Phase 2
18 Adjuvants, Anesthesia Phase 4
19 Adrenergic Agents Phase 4
20 Adrenergic Agonists Phase 4
21 Adrenergic alpha-2 Receptor Agonists Phase 4
22 Adrenergic alpha-Agonists Phase 4
23 Sodium Channel Blockers Phase 4
24 Cholinergic Agents Phase 4
25 GABA Agents Phase 4
26 Narcotics Phase 4,Phase 2
27 GABA Modulators Phase 4
28 Cholinergic Antagonists Phase 4
29 Neuromuscular Agents Phase 4
30 Neuromuscular Blocking Agents Phase 4
31 Neuromuscular Nondepolarizing Agents Phase 4
32 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
33 Tranquilizing Agents Phase 4
34 Analgesics, Non-Narcotic Phase 4
35 Analgesics, Opioid Phase 4,Phase 2
36 Anesthetics Phase 4
37 Anesthetics, General Phase 4
38 Anesthetics, Intravenous Phase 4
39 Anesthetics, Local Phase 4
40 Diuretics, Potassium Sparing Phase 4
41 Anti-Anxiety Agents Phase 4
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
43 Anti-Arrhythmia Agents Phase 4
44 Hypnotics and Sedatives Phase 4
45 Anticonvulsants Phase 4,Phase 3
46 Pharmaceutical Solutions Phase 4,Phase 3
47 Antimanic Agents Phase 4
48 Psychotropic Drugs Phase 4
49 Citrate Nutraceutical Phase 4
50
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696

Interventional clinical trials:

(show all 35)

# Name Status NCT ID Phase Drugs
1 Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus Unknown status NCT02518789 Phase 4 Low-dose Dexmedetomidine;High-dose dexmedetomidine;normal saline;Etomidate;midazolam,fentanyl,rocuronium;propofol,remifentanil,cis atracurium
2 Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia Unknown status NCT02141737 Phase 4 Lidocaine Hydrochloride Injection;Etomidate Fat Emulsion Injection;normal saline;Midazolam Injection;Fentanyl Citrate Injection;Rocuronium Injection
3 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
4 Sole Local Anesthetic Versus Opioid Plus Local Anesthesia in Epidural Labor Analgesia Completed NCT02036242 Phase 4 Sole local anesthetic;Sufentanil (Opioid plus local anesthetic);Ropivacaine
5 Efficacy Trial of Zonisamide for Myoclonus Dystonia Completed NCT01806805 Phase 3 zonegran;placebo
6 Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma Completed NCT00033293 Phase 3 cyclophosphamide;prednisone;Corticotropin-Releasing Hormone
7 Brivaracetam as add-on Treatment of Unverricht-Lundborg Disease (ULD) in Adolescents and Adults Completed NCT00368251 Phase 3 BRV 2.5 mg;BRV 25 mg;BRV 50 mg
8 Brivaracetam as add-on Treatment of Unverricht-Lundborg Disease in Adolescents and Adults Completed NCT00357669 Phase 3 Brivaracetam 25 mg;Brivaracetam 50 mg
9 Levetiracetam as add-on Treatment of Myoclonic Jerks in Adolescents + Adults Completed NCT00150774 Phase 3 Levetiracetam
10 Piracetam for Treatment Tardive Dyskinesia Completed NCT00190008 Phase 3 piracetam
11 Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg) Recruiting NCT01868269 Phase 3 Dexamethasone acetate;dexamethasone and cyclophosphamide;dexamethasone and rituximab
12 Intravenous Immunoglobulin for Unverricht-Lundborg Disease. Active, not recruiting NCT03351569 Phase 3 Intravenous immunoglobulin
13 Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma Unknown status NCT00202930 Phase 2 anti-CD20 (Rituximab)
14 Effect of Ropinirole Hydrochloride in Progressive Myoclonic Epilepsy of Unverricht-Lundborg Type Unknown status NCT00639119 Phase 2 Ropinirole
15 Effectiveness of Rituximab in Pediatric OMS Patients. Completed NCT00244361 Phase 1, Phase 2 rituximab
16 OGT 918-006: A Phase I/II Randomized, Controlled Study of OGT 918 in Patients With Neuronopathic Gaucher Disease Completed NCT00041535 Phase 2 OGT 918
17 Stem Cell Transplantation for Stiff Person Syndrome (SPS) Recruiting NCT02282514 Phase 1, Phase 2
18 Pilot Efficacy Study of T2000 in Myoclonus Dystonia Terminated NCT00506012 Phase 2 T2000
19 Role of Methadone As Co-Opioid Analgesic Terminated NCT00558870 Phase 2 Morphine;Methadone
20 Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation Completed NCT00001663 Phase 1
21 Tonicity Monitor For Epilepsy and Hypertonic Disorders Unknown status NCT02110589
22 Study of Cytokines in Children With Opsoclonus-Myoclonus Syndrome Completed NCT00806182
23 Ketogenic Diet in Lafora Disease Completed NCT00007124
24 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus
25 Parenteral Hydration in Advanced Cancer Patients Completed NCT00423722 Saline;Saline
26 Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases Completed NCT00001667
27 Effect of Levetiracetam on Brain Excitability Completed NCT00006191
28 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714
29 Agency in Dystonia Recruiting NCT03351218
30 The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias Recruiting NCT01373424
31 Predictive Electrophysiological Score of the Neurological Prognosis Post Cardiac Arrest Recruiting NCT02886039
32 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
33 The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes Recruiting NCT03383354
34 Phenotype/Genotype Correlations in Movement Disorders Recruiting NCT00018889
35 Botulinum Toxin for the Treatment of Involuntary Movement Disorders Recruiting NCT00001208

Search NIH Clinical Center for Myoclonus

Genetic Tests for Myoclonus

Genetic tests related to Myoclonus:

# Genetic test Affiliating Genes
1 Myoclonus 28

Anatomical Context for Myoclonus

MalaCards organs/tissues related to Myoclonus:

38
Brain, Spinal Cord, Kidney, Liver, Eye, Lung, Cortex

Publications for Myoclonus

Articles related to Myoclonus:

(show top 50) (show all 1196)
# Title Authors Year
1
Teaching Video NeuroImages: Delayed hemibody myorhythmia and palatal myoclonus after vertebrobasilar stroke. ( 29438032 )
2018
2
Electrophysiologic testing aids diagnosis and subtyping of myoclonus. ( 29352095 )
2018
3
Corrigendum to "Dexamethasone, Intravenous Immunoglobulin, and Rituximab Combination Immunotherapy for Pediatric Opsoclonus-Myoclonus Syndrome" [Pediatric Neurology 73 (2017) 48-56]. ( 29169865 )
2018
4
Ocular bobbing/dipping after cardiac arrest may be a post-anoxic myoclonus. ( 29307541 )
2018
5
Effect of repetitive transcranial magnetic stimulation on action myoclonus: A pilot study in patients with EPM1. ( 29396360 )
2018
6
Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): a randomised, open-label, phase 3 trial. ( 29376112 )
2018
7
Astrocytes: new players in progressive myoclonus epilepsy of Lafora type. ( 29408991 )
2018
8
Novel SGCE mutation in a patient with myoclonus-dystonia syndrome - Diagnostic delay of more than 40a8^years. ( 29429788 )
2018
9
Unexpected Falls During Clozapine Treatment Explained by Myoclonus. ( 29360288 )
2018
10
Reappraisal of cortical myoclonus: A retrospective study of clinical neurophysiology. ( 29193325 )
2018
11
Dexamethasone-Based Multimodal Therapy for Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome: Is It Really Superior? ( 29169870 )
2018
12
Treatment of Post Anoxic Action Myoclonus with Intrathecal Baclofen: A Case Report. ( 29366919 )
2018
13
Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome. ( 29135842 )
2018
14
HIV-associated opsoclonus-myoclonus-ataxia syndrome: early infection, immune reconstitution syndrome or secondary to other diseases? Case report and literature review. ( 29243132 )
2018
15
Longitudinal multi-modal neuroimaging in opsoclonus-myoclonus syndrome. ( 28054126 )
2017
16
Myoclonus and hypersensitivity of the tail following intrathecal administration of morphine and bupivacaine in a cat. ( 29428303 )
2017
17
Benign Neonatal Sleep Myoclonus Evokes Somatosensory Responses. ( 28922194 )
2017
18
Alcohol improves cerebellar learning deficit in myoclonus-dystonia: A clinical and electrophysiological investigation. ( 28869676 )
2017
19
Therapeutic plasma exchange for a case of refractory opsoclonus myoclonus ataxia syndrome. ( 28926689 )
2017
20
Childhood opsoclonus-myoclonus syndrome: A case series from Tunisia. ( 28549713 )
2017
21
Comment on "Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases". ( 28874310 )
2017
22
Lead Poisoning: Myoclonus Following Welding Exposure. ( 29364803 )
2017
23
Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy. ( 28740856 )
2017
24
Gerstmann-Straussler-Scheinker disease with PRNP P102L heterozygous mutation presenting as progressive myoclonus epilepsy. ( 29148226 )
2017
25
Rapidly progressive dementia with myoclonus: Not Creutzfeldt-Jakob disease. ( 28290426 )
2017
26
Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition. ( 28823931 )
2017
27
Rituximab, IVIg, and Tetracosactide (ACTH1-24) Combination Immunotherapy ("RITE-CI") for Pediatric Opsoclonus-Myoclonus Syndrome: Immunomarkers and Clinical Observations. ( 29258131 )
2017
28
Classification of Involuntary Movements in Dogs: Myoclonus and Myotonia. ( 28557061 )
2017
29
Sleep-Related Laryngeal Stridor in Opsoclonus Myoclonus Syndrome. ( 28823798 )
2017
30
Myoclonus After Cardiac Arrest: Where Do We Go From Here? ( 29225535 )
2017
31
Stimulus-sensitive myoclonus with trigeminal neuralgia. ( 28906076 )
2017
32
Immunosuppressive therapy in opsoclonus-myoclonus ataxia syndrome associated with paravertebral neuroblastoma. ( 28865946 )
2017
33
Low CSF 5-HIAA in Myoclonus Dystonia. ( 28949039 )
2017
34
Reply to van Gerpen and Hassan comment on "Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases". ( 28874311 )
2017
35
An autopsied case of corticobasal degeneration presenting with frontotemporal dementia followed by myoclonus. ( 28707717 )
2017
36
Update on pharmacological treatment of Progressive Myoclonus Epilepsies. ( 28799509 )
2017
37
Movement-activated cortical myoclonus in Dravet syndrome. ( 28126647 )
2017
38
Novel De Novo KCND3 Mutation in a Japanese Patient with Intellectual Disability, Cerebellar Ataxia, Myoclonus, and Dystonia. ( 28895081 )
2017
39
A case of Bickerstaff brainstem encephalitis with transient reflex myoclonus. ( 28637936 )
2017
40
Treatment of Propriospinal Myoclonus at Sleep Onset. ( 28516739 )
2017
41
Dexamethasone, Intravenous Immunoglobulin, and Rituximab Combination Immunotherapy for Pediatric Opsoclonus-Myoclonus Syndrome. ( 28651977 )
2017
42
A Case of Myoclonus-Dystonia Responding to Low-frequency Pallidal Stimulation. ( 28503362 )
2017
43
The efficacy of the modified Atkins diet in North Sea Progressive Myoclonus Epilepsy: an observational prospective open-label study. ( 28264719 )
2017
44
Myoclonus as a late manifestation of West Nile disease. ( 29170190 )
2017
45
Relative Incidence of Seizures and Myoclonus in Alzheimer's Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia. ( 28826176 )
2017
46
Teaching Video NeuroImages: Maneuvers to elicit opsoclonus in opsoclonus-myoclonus syndrome. ( 28416624 )
2017
47
Demographic, Clinical, and Immunologic Features of 389 Children with Opsoclonus-Myoclonus Syndrome: A Cross-sectional Study. ( 28959231 )
2017
48
Brain volumetric analysis and cortical thickness in adults with saccadic intrusions (ocular flutter or opsoclonus-myoclonus syndrome). ( 29121544 )
2017
49
Opsoclonus myoclonus syndrome in a patient with Japanese encephalitis: a case report. ( 29058581 )
2017
50
Postintervention acute opsoclonus myoclonus syndrome. ( 28432174 )
2017

Variations for Myoclonus

ClinVar genetic disease variations for Myoclonus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC2A1 NM_006516.2(SLC2A1): c.470dupG (p.Thr158Hisfs) duplication Pathogenic rs1057518821 GRCh37 Chromosome 1, 43396343: 43396343

Expression for Myoclonus

Search GEO for disease gene expression data for Myoclonus.

Pathways for Myoclonus

GO Terms for Myoclonus

Biological processes related to Myoclonus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein ubiquitination GO:0031398 8.96 NHLRC1 PRICKLE1
2 glycogen biosynthetic process GO:0005978 8.62 EPM2A NHLRC1

Sources for Myoclonus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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