Aliases & Classifications for Myoclonus

MalaCards integrated aliases for Myoclonus:

Name: Myoclonus 51 29

Classifications:



External Ids:

ICD10 33 G25.3

Summaries for Myoclonus

NINDS : 51 Myoclonus refers to a sudden, involuntary jerking of a muscle or group of muscles. In its simplest form, myoclonus consists of a muscle twitch followed by relaxation. A hiccup is an example of this type of myoclonus. Other familiar examples of myoclonus are the jerks or "sleep starts" that some people experience while drifting off to sleep.  These simple forms of myoclonus occur in normal, healthy persons and cause no difficulties. When more widespread, myoclonus may involve persistent, shock-like contractions in a group of muscles.  Myoclonic jerking may develop in people with multiple sclerosis, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jakob disease. Myoclonic jerks commonly occur in persons with epilepsy, a disorder in which the electrical activity in the brain becomes disordered and leads to seizures.  Myoclonus may develop in response to infection, head or spinal cord injury, stroke, brain tumors, kidney or liver failure, lipid storage disease, chemical or drug poisoning, or other disorders.  It can occur by itself, but most often it is one of several symptoms  associated with a wide variety of nervous system disorders.

MalaCards based summary : Myoclonus is related to opsoclonus-myoclonus syndrome and myoclonus, familial cortical. An important gene associated with Myoclonus is SLC2A1 (Solute Carrier Family 2 Member 1). The drugs Dexmedetomidine and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and liver, and related phenotypes are behavior/neurological and cellular

Wikipedia : 72 Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. It describes a medical... more...

Related Diseases for Myoclonus

Diseases related to Myoclonus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
id Related Disease Score Top Affiliating Genes
1 opsoclonus-myoclonus syndrome 12.4
2 myoclonus, familial cortical 12.2
3 progressive myoclonus epilepsy 12.1
4 prickle1-related progressive myoclonus epilepsy with ataxia 12.1
5 progressive myoclonus epilepsy, lafora type 12.1
6 propriospinal myoclonus 12.0
7 myoclonus, cerebellar ataxia, and deafness 12.0
8 myoclonus, intractable, neonatal 12.0
9 myoclonus epilepsy 11.9
10 progressive encephalomyelitis with rigidity and myoclonus 11.8
11 gosr2-related progressive myoclonus ataxia 11.8
12 dystonia-11, myoclonic 11.8
13 faciomandibular myoclonus, nocturnal 11.7
14 myoclonus epilepsy partial seizure 11.7
15 sialidosis, type i 11.7
16 unverricht-lundborg syndrome 11.6
17 epilepsy, progressive myoclonic 4, with or without renal failure 11.6
18 epilepsy, progressive myoclonic 6 11.4
19 myoclonic epilepsy associated with ragged-red fibers 11.4
20 epilepsy, progressive myoclonic 2b 11.4
21 epilepsy, progressive myoclonic 7 11.3
22 myoclonic cerebellar dyssynergia 11.3
23 periodic limb movement disorder 11.3
24 jankovic rivera syndrome 11.3
25 epileptic encephalopathy, early infantile, 6 11.3
26 spinal muscular atrophy with progressive myoclonic epilepsy 11.3
27 epilepsy, generalized, with febrile seizures plus, type 5 11.2
28 epilepsy, myoclonic, familial adult, 2 11.2
29 epilepsy, progressive myoclonic, 9 11.2
30 epilepsy, progressive myoclonic, 8 11.2
31 galactosialidosis 11.1
32 psychogenic movement 11.0
33 geniospasm 1 11.0
34 corticobasal degeneration 11.0
35 stiff-person syndrome 11.0
36 creutzfeldt-jakob disease 10.9
37 mitochondrial disorders 10.9
38 ataxia-telangiectasia 10.9
39 dentatorubro-pallidoluysian atrophy 10.9
40 epilepsy, progressive myoclonic 1a 10.9
41 epilepsy, progressive myoclonic, 10 10.8
42 ceroid lipofuscinosis, neuronal, 7 10.8
43 myoclonic encephalopathy of infants 10.8
44 immunodeficiency 23 10.8
45 epilepsy, progressive myoclonic 3, with or without intracellular inclusions 10.8
46 glycoproteinosis 10.8
47 benign adult familial myoclonic epilepsy 10.8
48 epileptic encephalopathy, early infantile, 3 10.7
49 ceroid lipofuscinosis, neuronal, 2 10.7
50 chorea, hereditary benign 10.7

Graphical network of the top 20 diseases related to Myoclonus:



Diseases related to Myoclonus

Symptoms & Phenotypes for Myoclonus

MGI Mouse Phenotypes related to Myoclonus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 SLC2A1 NEU1 NHLRC1 PRICKLE1 CERS1 CSTB
2 cellular MP:0005384 9.91 SLC2A1 NEU1 NHLRC1 NOL3 PRICKLE1 CERS1
3 cardiovascular system MP:0005385 9.8 NEU1 NOL3 PRICKLE1 SCARB2 SGCE EPM2A
4 muscle MP:0005369 9.7 NEU1 NHLRC1 NOL3 PRICKLE1 CSTB SGCE
5 nervous system MP:0003631 9.61 SLC2A1 NEU1 NHLRC1 PRICKLE1 CERS1 CSTB
6 no phenotypic analysis MP:0003012 9.02 SLC2A1 NEU1 NHLRC1 PRICKLE1 CSTB

Drugs & Therapeutics for Myoclonus

Drugs for Myoclonus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2
Etomidate Approved Phase 4 33125-97-2 36339 667484
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Remifentanil Approved Phase 4 132875-61-7 60815
7
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
10
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
11
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
12
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
13 Cisatracurium Experimental Phase 4 96946-41-7
14 Adjuvants, Anesthesia Phase 4
15 Adrenergic Agents Phase 4
16 Adrenergic Agonists Phase 4
17 Adrenergic alpha-2 Receptor Agonists Phase 4
18 Adrenergic alpha-Agonists Phase 4
19 Analgesics Phase 4,Phase 2
20 Analgesics, Non-Narcotic Phase 4
21 Analgesics, Opioid Phase 4,Phase 2
22 Anesthetics Phase 4
23 Anesthetics, General Phase 4
24 Anesthetics, Intravenous Phase 4
25 Anti-Anxiety Agents Phase 4
26
Atracurium Phase 4 64228-79-1 47319
27 Central Nervous System Depressants Phase 4,Phase 2
28 Cholinergic Agents Phase 4
29 Cholinergic Antagonists Phase 4
30 GABA Agents Phase 4
31 GABA Modulators Phase 4
32 Hypnotics and Sedatives Phase 4
33 Narcotics Phase 4,Phase 2
34 Neuromuscular Agents Phase 4
35 Neuromuscular Blocking Agents Phase 4
36 Neuromuscular Nondepolarizing Agents Phase 4
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
39 Pharmaceutical Solutions Phase 4
40 Psychotropic Drugs Phase 4
41 Tranquilizing Agents Phase 4
42 Anesthetics, Local Phase 4
43 Anti-Arrhythmia Agents Phase 4
44 Diuretics, Potassium Sparing Phase 4
45 Sodium Channel Blockers Phase 4
46 Anticonvulsants Phase 4,Phase 3
47 Antimanic Agents Phase 4
48 Citrate Nutraceutical Phase 4
49
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
50
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696

Interventional clinical trials:

(show all 32)

id Name Status NCT ID Phase Drugs
1 Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus Unknown status NCT02518789 Phase 4 Low-dose Dexmedetomidine;High-dose dexmedetomidine;normal saline;Etomidate;midazolam,fentanyl,rocuronium;propofol,remifentanil,cis atracurium
2 Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia Unknown status NCT02141737 Phase 4 Lidocaine Hydrochloride Injection;Etomidate Fat Emulsion Injection;normal saline;Midazolam Injection;Fentanyl Citrate Injection;Rocuronium Injection
3 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
4 Sole Local Anesthetic Versus Opioid Plus Local Anesthesia in Epidural Labor Analgesia Completed NCT02036242 Phase 4 Sole local anesthetic;Sufentanil (Opioid plus local anesthetic);Ropivacaine
5 Efficacy Trial of Zonisamide for Myoclonus Dystonia Completed NCT01806805 Phase 3 zonegran;placebo
6 Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma Completed NCT00033293 Phase 3 cyclophosphamide;prednisone;Corticotropin-Releasing Hormone
7 Brivaracetam as add-on Treatment of Unverricht-Lundborg Disease (ULD) in Adolescents and Adults Completed NCT00368251 Phase 3 BRV 2.5 mg;BRV 25 mg;BRV 50 mg
8 Brivaracetam as add-on Treatment of Unverricht-Lundborg Disease in Adolescents and Adults Completed NCT00357669 Phase 3 Brivaracetam 25 mg;Brivaracetam 50 mg
9 Levetiracetam as add-on Treatment of Myoclonic Jerks in Adolescents + Adults Completed NCT00150774 Phase 3 Levetiracetam
10 Piracetam for Treatment Tardive Dyskinesia Completed NCT00190008 Phase 3 piracetam
11 Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg) Recruiting NCT01868269 Phase 3 Dexamethasone acetate;dexamethasone and cyclophosphamide;dexamethasone and rituximab
12 Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma Unknown status NCT00202930 Phase 2 anti-CD20 (Rituximab)
13 Effect of Ropinirole Hydrochloride in Progressive Myoclonic Epilepsy of Unverricht-Lundborg Type Unknown status NCT00639119 Phase 2 Ropinirole
14 Effectiveness of Rituximab in Pediatric OMS Patients. Completed NCT00244361 Phase 1, Phase 2 rituximab
15 OGT 918-006: A Phase I/II Randomized, Controlled Study of OGT 918 in Patients With Neuronopathic Gaucher Disease Completed NCT00041535 Phase 2 OGT 918
16 Stem Cell Transplantation for Stiff Person Syndrome (SPS) Recruiting NCT02282514 Phase 1, Phase 2
17 Pilot Efficacy Study of T2000 in Myoclonus Dystonia Terminated NCT00506012 Phase 2 T2000
18 Role of Methadone As Co-Opioid Analgesic Terminated NCT00558870 Phase 2 Morphine;Methadone
19 Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation Completed NCT00001663 Phase 1
20 Tonicity Monitor For Epilepsy and Hypertonic Disorders Unknown status NCT02110589
21 Study of Cytokines in Children With Opsoclonus-Myoclonus Syndrome Completed NCT00806182
22 Ketogenic Diet in Lafora Disease Completed NCT00007124
23 Immunotherapy of the Paraneoplastic Syndromes Completed NCT00378326 Tacrolimus
24 Parenteral Hydration in Advanced Cancer Patients Completed NCT00423722 Saline;Saline
25 Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases Completed NCT00001667
26 Effect of Levetiracetam on Brain Excitability Completed NCT00006191
27 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714
28 The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias Recruiting NCT01373424
29 Predictive Electrophysiological Score of the Neurological Prognosis Post Cardiac Arrest Recruiting NCT02886039
30 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
31 Phenotype/Genotype Correlations in Movement Disorders Recruiting NCT00018889
32 Botulinum Toxin for the Treatment of Involuntary Movement Disorders Recruiting NCT00001208

Search NIH Clinical Center for Myoclonus

Genetic Tests for Myoclonus

Genetic tests related to Myoclonus:

id Genetic test Affiliating Genes
1 Myoclonus 29

Anatomical Context for Myoclonus

MalaCards organs/tissues related to Myoclonus:

39
Brain, Spinal Cord, Liver, Kidney, Eye, Lung, Cortex

Publications for Myoclonus

Articles related to Myoclonus:

(show top 50) (show all 1162)
id Title Authors Year
1
Myoclonus epilepsy and ataxia due to KCNC1 mutation: Analysis of 20 cases and K(+) channel properties. ( 28380698 )
2017
2
Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome. ( 28102628 )
2017
3
Stimulus-sensitive myoclonus with trigeminal neuralgia. ( 28906076 )
2017
4
Chronic encephalopathy with ataxia, myoclonus, and auditory neuropathy: A case of bismuth poisoning. ( 28084272 )
2017
5
Teaching Video NeuroImages: Maneuvers to elicit opsoclonus in opsoclonus-myoclonus syndrome. ( 28416624 )
2017
6
Spinal Myoclonus Responding to Continuous Intrathecal Morphine Pump. ( 28889721 )
2017
7
Classification of Involuntary Movements in Dogs: Myoclonus and Myotonia. ( 28557061 )
2017
8
An autopsied case of corticobasal degeneration presenting with frontotemporal dementia followed by myoclonus. ( 28707717 )
2017
9
Movement-activated cortical myoclonus in Dravet syndrome. ( 28126647 )
2017
10
Treatment of Propriospinal Myoclonus at Sleep Onset. ( 28516739 )
2017
11
Epileptic Negative Myoclonus as the First and Only Symptom in a Challenging Diagnosis of Benign Epilepsy With Centrotemporal Spikes. ( 28815192 )
2017
12
Reply to van Gerpen and Hassan comment on "Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases". ( 28874311 )
2017
13
Relative Incidence of Seizures and Myoclonus in Alzheimer's Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia. ( 28826176 )
2017
14
Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials. ( 28761332 )
2017
15
Therapeutic plasma exchange for a case of refractory opsoclonus myoclonus ataxia syndrome. ( 28926689 )
2017
16
Progressive Encephalomyelitis with Rigidity and Myoclonus in an Intellectually Disabled Patient Mimicking Neuroleptic Malignant Syndrome. ( 28352055 )
2017
17
Redefining progressive encephalomyelitis with rigidity and myoclonus after the discovery of antibodies to glycine receptors. ( 28306573 )
2017
18
Alcohol improves cerebellar learning deficit in myoclonus-dystonia: A clinical and electrophysiological investigation. ( 28869676 )
2017
19
Immunosuppressive therapy in opsoclonus-myoclonus ataxia syndrome associated with paravertebral neuroblastoma. ( 28865946 )
2017
20
A Case of Myoclonus-Dystonia Responding to Low-frequency Pallidal Stimulation. ( 28503362 )
2017
21
Childhood opsoclonus-myoclonus syndrome: A case series from Tunisia. ( 28549713 )
2017
22
Opsoclonus-Myoclonus Syndrome: A New Era of Improved Prognosis? ( 28479124 )
2017
23
Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. ( 28139826 )
2017
24
Longitudinal multi-modal neuroimaging in opsoclonus-myoclonus syndrome. ( 28054126 )
2017
25
Comment on "Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases". ( 28874310 )
2017
26
The efficacy of the modified Atkins diet in North Sea Progressive Myoclonus Epilepsy: an observational prospective open-label study. ( 28264719 )
2017
27
An unusual complication of anesthesia: Unilateral spinal myoclonus. ( 28895986 )
2017
28
Novel De Novo KCND3 Mutation in a Japanese Patient with Intellectual Disability, Cerebellar Ataxia, Myoclonus, and Dystonia. ( 28895081 )
2017
29
Dexamethasone, Intravenous Immunoglobulin, and Rituximab Combination Immunotherapy for Pediatric Opsoclonus-Myoclonus Syndrome. ( 28651977 )
2017
30
A Rare Instance of Levofloxacin Induced Myoclonus. ( 28892927 )
2017
31
A case of Bickerstaff brainstem encephalitis with transient reflex myoclonus. ( 28637936 )
2017
32
Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition. ( 28823931 )
2017
33
Rapidly progressive dementia with myoclonus: Not Creutzfeldt-Jakob disease. ( 28290426 )
2017
34
Update on pharmacological treatment of Progressive Myoclonus Epilepsies. ( 28799509 )
2017
35
Progressive Encephalomyelitis with Rigidity and Myoclonus Associated With Anti-GlyR Antibodies and Hodgkin's Lymphoma: A Case Report. ( 28848493 )
2017
36
Postintervention acute opsoclonus myoclonus syndrome. ( 28432174 )
2017
37
Benign Neonatal Sleep Myoclonus Evokes Somatosensory Responses. ( 28922194 )
2017
38
Thymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis. ( 28674368 )
2017
39
Opsoclonus-myoclonus syndrome following long-term use of cyclosporine. ( 28905654 )
2017
40
Opsoclonus-Myoclonus Syndrome during Rituximab Treatment for Autoimmune Autonomic Ganglionopathy. ( 28740856 )
2017
41
Low CSF 5-HIAA in Myoclonus Dystonia. ( 28949039 )
2017
42
Sleep-Related Laryngeal Stridor in Opsoclonus Myoclonus Syndrome. ( 28823798 )
2017
43
Childhood opsoclonus-myoclonus syndrome: diagnosis and treatment. ( 27095464 )
2016
44
Four cases of orthostatic myoclonus. ( 26916904 )
2016
45
Progressive encephalomyelitis with rigidity and myoclonus (PERM): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab. ( 26788132 )
2016
46
Laryngeal myoclonus. ( 26979350 )
2016
47
Chronic negative myoclonus with hypercapnic encephalopathy. ( 27604982 )
2016
48
Trends and tenets in relapsing and progressive opsoclonus-myoclonus syndrome. ( 26786246 )
2016
49
Encephalopathy with upper body hypertonia and myoclonus in patient with systemic lupus erythematosus and anti-CASPR2. ( 27432809 )
2016
50
A randomized, controlled, double-blind, crossover trial of zonisamide in myoclonus-dystonia. ( 27053715 )
2016

Variations for Myoclonus

ClinVar genetic disease variations for Myoclonus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SLC2A1 NM_006516.2(SLC2A1): c.470dupG (p.Thr158Hisfs) duplication Pathogenic rs1057518821 GRCh38 Chromosome 1, 42930672: 42930672

Expression for Myoclonus

Search GEO for disease gene expression data for Myoclonus.

Pathways for Myoclonus

GO Terms for Myoclonus

Biological processes related to Myoclonus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein ubiquitination GO:0031398 8.96 NHLRC1 PRICKLE1
2 glycogen biosynthetic process GO:0005978 8.62 EPM2A NHLRC1

Sources for Myoclonus

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