MCID: MYP002
MIFTS: 38

Myoepithelial Carcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Myoepithelial Carcinoma

MalaCards integrated aliases for Myoepithelial Carcinoma:

Name: Myoepithelial Carcinoma 12 50 14
Malignant Myoepithelioma 50 69
Myoepithelioma Carcinoma 50

Classifications:



External Ids:

Disease Ontology 12 DOID:4838
NCIt 47 C7596
SNOMED-CT 64 128884000 24292006
UMLS 69 C0334699

Summaries for Myoepithelial Carcinoma

NIH Rare Diseases : 50 myoepithelial carcinoma is a rare malignant (cancerous) tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. the average age of diagnosis is 55 years. symptoms of myoepithelial carcinoma usually begin with a painless mass. other symptoms vary depending on the site of the tumor and may include: hoarseness, nasal blockage, bleeding from the nose, pain, headaches, and facial weakness and paralysis. treatment depends on the location and stage of the tumor. treatment options may include surgery to remove the affected tissues, radiation therapy, and chemotherapy. last updated: 11/18/2016

MalaCards based summary : Myoepithelial Carcinoma, also known as malignant myoepithelioma, is related to epithelial-myoepithelial carcinoma and breast myoepithelial neoplasm. An important gene associated with Myoepithelial Carcinoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Axitinib and Imatinib Mesylate have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and breast, and related phenotype is vision/eye.

Disease Ontology : 12 A carcinoma that derives from myoepithelial cells.

Related Diseases for Myoepithelial Carcinoma

Diseases related to Myoepithelial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
id Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 12.2
2 breast myoepithelial neoplasm 10.9
3 lymphocytic hypophysitis 10.7 ACTC1 VIM
4 gastric signet ring cell adenocarcinoma 10.7 ACTC1 VIM
5 aortic aneurysm 10.7 ACTC1 VIM
6 iridogoniodysgenesis and skeletal anomalies 10.7 ACTC1 VIM
7 skin lipoma 10.7 ACTC1 VIM
8 uniparental disomy of chromosome 11 10.7 ACTC1 VIM
9 myxoid leiomyosarcoma 10.7 ACTC1 VIM
10 berk-tabatznik syndrome 10.7 ACTC1 VIM
11 follicular infundibulum tumor 10.7 ACTC1 VIM
12 juvenile xanthogranuloma 10.6 ACTC1 VIM
13 2q31.1 microdeletion syndrome 10.6 MUC1 VIM
14 nephrogenic adenoma of urinary bladder 10.6 ACTC1 VIM
15 group b strep disease in newborns 10.6 ACTC1 VIM
16 pseudounicornuate uterus 10.6 TP63 VIM
17 glomangioma 10.6 ACTC1 VIM
18 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.6 MUC1 VIM
19 large cell acanthoma 10.6 ACTC1 VIM
20 mannose-binding lectin protein deficiency 10.6 MUC1 VIM
21 multiple mitochondrial dysfunctions syndrome 2 10.6 ACTC1 VIM
22 vulvar angiokeratoma 10.6 MUC1 VIM
23 noninvasive malignant thymoma 10.6 MUC1 VIM
24 pancreatic intraductal papillary-colloid carcinoma 10.6 MUC1 VIM
25 bladder colloid adenocarcinoma 10.6 MUC1 VIM
26 lice infestation 10.6 MUC1 VIM
27 benign familial neonatal epilepsy 10.6 ACTC1 VIM
28 persian gulf syndrome 10.6 MUC1 VIM
29 diffuse meningeal melanocytosis 10.5 MUC1 VIM
30 childhood pleomorphic rhabdomyosarcoma 10.5 MUC1 VIM
31 pancreatic serous cystadenoma 10.5 MUC1 VIM
32 ovarian mucinous adenocarcinoma 10.5 MUC1 VIM
33 extraskeletal mesenchymal chondrosarcoma 10.5 MUC1 VIM
34 pancreatic ductal carcinoma 10.5 MUC1 VIM
35 secondary syphilis 10.5 MUC1 VIM
36 neonatal respiratory failure 10.5 KRT14 TP63
37 neurofibroma of the esophagus 10.5 ACTC1 MUC1
38 hip subluxation 10.5 TP63 VIM
39 spastic ataxia 3 10.5 MUC1 VIM
40 thymic dysplasia 10.5 MUC1 TP63
41 vulvar keratoacanthoma-like carcinoma 10.5 MUC1 VIM
42 angelman syndrome due to imprinting defect in 15q11-q13 10.5 ACTC1 VIM
43 lip carcinoma in situ 10.4 ACTC1 MUC1
44 chondroblastoma 10.4 MUC1 VIM
45 kidney benign neoplasm 10.4 MUC1 VIM
46 mitochondrial myopathy with lactic acidosis 10.4 MUC1 VIM
47 intellectual disability-polydactyly-uncombable hair syndrome 10.4 GFAP VIM
48 basosquamous carcinoma 10.4 GFAP VIM
49 mediastinal osteogenic sarcoma 10.4 MUC1 VIM
50 anaplastic plasmacytoma 10.4 ACTC1 GFAP

Graphical network of the top 20 diseases related to Myoepithelial Carcinoma:



Diseases related to Myoepithelial Carcinoma

Symptoms & Phenotypes for Myoepithelial Carcinoma

MGI Mouse Phenotypes related to Myoepithelial Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 KRT14 PLIN2 TP63 VIM GFAP

Drugs & Therapeutics for Myoepithelial Carcinoma

Drugs for Myoepithelial Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
2 Imatinib Mesylate Phase 2 123596
3 Protein Kinase Inhibitors Phase 2
4 lysine Nutraceutical Phase 2,Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Imatinib Mesylate in Treating Patients With Salivary Gland Cancer Completed NCT00045669 Phase 2 imatinib mesylate
2 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
3 Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14 Recruiting NCT02857712 Phase 2 Axitinib
4 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2
5 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat

Search NIH Clinical Center for Myoepithelial Carcinoma

Genetic Tests for Myoepithelial Carcinoma

Anatomical Context for Myoepithelial Carcinoma

MalaCards organs/tissues related to Myoepithelial Carcinoma:

39
Salivary Gland, Skin, Breast, Lung, Tongue, Trachea, Prostate

Publications for Myoepithelial Carcinoma

Articles related to Myoepithelial Carcinoma:

(show top 50) (show all 314)
id Title Authors Year
1
Myoepithelial carcinoma with RB1 mutation: remarkable chemosensitivity to carcinoma of unknown origin therapy. ( 28390395 )
2017
2
Image Gallery: Myoepithelial carcinoma involving the skin. ( 28244091 )
2017
3
Cutaneous myoepithelial carcinoma with disseminated metastases. ( 28686765 )
2017
4
Myoepithelial carcinoma of the salivary gland: pathologic and CT imaging characteristics (report of 10 cases and literature review). ( 28153562 )
2017
5
Epithelio- Myoepithelial Carcinoma of Masseteric Space: a Case Report. ( 28546730 )
2017
6
Clear Cell Myoepithelial Carcinoma of the Upper Lip -A Rare Case Report. ( 28272678 )
2017
7
Myoepithelial Carcinoma of the Paracecal Mesentery: Aggressive Behavior of a Rare Neoplasm at an Unusual Anatomic Site. ( 28458787 )
2017
8
Primary myoepithelial carcinoma of the lung and (18)F-FDG PET/CT. ( 28610871 )
2017
9
Congenital Myoepithelial Carcinoma of Soft Tissue Associated With Cystic Myoepithelioma. ( 28675958 )
2017
10
First case report of a curative wedge resection in epithelial-myoepithelial carcinoma of the lung. ( 28653299 )
2017
11
Myoepithelial Carcinoma of the Thigh after Lipoma Excision. ( 28822356 )
2017
12
Case of myoepithelial carcinoma on scalp. ( 28464327 )
2017
13
De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report. ( 28454450 )
2017
14
Salivary epithelial-myoepithelial carcinoma: clinical, morphological and molecular features. ( 28635988 )
2017
15
A spontaneous myoepithelial carcinoma in the mammary gland of an aged female ICR (CD-1) mouse. ( 28798533 )
2017
16
Myoepithelial Carcinoma: The Role of Radiation Therapy. A Case Report and Analysis of Data From the Surveillance, Epidemiology, and End Results (SEER) Registry. ( 26886377 )
2016
17
Clinicopathological characteristics and cell cycle proteins as potential prognostic factors in myoepithelial carcinoma of salivary glands. ( 26710792 )
2016
18
Soft Tissue Myoepithelial Carcinoma Metastatic to the Cecum: Highlighting an Unusual Metastatic Pattern and the Need for Diagnostic Awareness. ( 27134707 )
2016
19
Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall. ( 27614667 )
2016
20
Epithelial-myoepithelial carcinoma arising from the subglottis: a case report and review of the literature. ( 26922486 )
2016
21
Expanding the Spectrum of Renal Tumors in Children: Primary Renal Myoepithelial Carcinomas With a Novel EWSR1-KLF15 Fusion. ( 26523541 )
2016
22
Myoepithelial carcinoma of the vallecula: A case report and review of the literature. ( 27123078 )
2016
23
Pleural fluid metastases of myoepithelial carcinoma: A case report and review of the literature. ( 27382407 )
2016
24
Myoepithelial carcinoma in the mediastinum involving the left atrium. ( 26429764 )
2016
25
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. ( 26934566 )
2016
26
A rare case of primary peripheral epithelial myoepithelial carcinoma of lung: Case report and literature review. ( 27583848 )
2016
27
Cytomorphologic Attributes of Epithelial Myoepithelial Carcinoma of Nasal Cavity - A Rare Tumor with Unusual Clinical Presentation. ( 27790447 )
2016
28
Myoepithelial carcinoma on the right shoulder: Case report with published work review. ( 26989835 )
2016
29
Chromosomal rearrangements in myoepithelial carcinoma of the breast that presented as metachronic double cancer with invasive ductal carcinoma in the ipsilateral breast. ( 27886676 )
2016
30
Epithelial-Myoepithelial Carcinoma of the Salivary Gland Harboring HRAS Codon 61 Mutations With Lung Metastasis. ( 26675036 )
2016
31
Sinonasal epithelial-myoepithelial carcinoma: A case report. ( 27773082 )
2016
32
Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports. ( 27793123 )
2016
33
Recurrent myoepithelial carcinoma of the submandibular gland treated by rAd-p53 combined with radiotherapy: A case report. ( 27446369 )
2016
34
Going beyond "Basaloid neoplasm": Fine needle aspiration cytology of epithelial-myoepithelial carcinoma of the parotid gland. ( 26798976 )
2016
35
Prognostic Factors in Myoepithelial Carcinoma of the Major Salivary Glands. ( 27048677 )
2016
36
Soft Tissue Myoepithelial Carcinoma in a Child: Case Report. ( 27104831 )
2016
37
(125)I interstitial brachytherapy for the treatment of myoepithelial carcinoma of the oral and maxillofacial region. ( 26778756 )
2016
38
Epithelial-myoepithelial carcinoma of the minor salivary glands: a case report and review of the literature. ( 27599278 )
2016
39
Soft Tissue Myoepithelial Carcinoma of the Neck with Spinal Invasion. ( 27746887 )
2016
40
Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. ( 25581728 )
2015
41
Epithelial-myoepithelial carcinoma metastasis to the thoracic spine. ( 26474503 )
2015
42
Pneumocytic adenomyoepithelioma in a case of myoepithelial carcinoma of the submandibular gland. ( 26853410 )
2015
43
Global transcriptome and sequenome analysis of formalin-fixed salivary epithelial-myoepithelial carcinoma specimens. ( 25546727 )
2015
44
Epithelial-Myoepithelial Carcinoma of the Salivary Glands: An Analysis of 246 Cases. ( 26195572 )
2015
45
High-grade epithelial-myoepithelial carcinoma of the parotid gland with mucous cell differentiation. ( 26037059 )
2015
46
Tracheal epithelial-myoepithelial carcinoma associated with sarcoid-like reaction: A case report. ( 26029574 )
2015
47
Bilateral epithelial-myoepithelial carcinoma of the parotid glands. ( 26314935 )
2015
48
A Rare Case of Bronchial Epithelial-Myoepithelial Carcinoma with Solid Lobular Growth in a 53-Year-Old Woman. ( 26508939 )
2015
49
Salivary Gland Epithelial-Myoepithelial Carcinoma with High-Grade Transformation in a Dog. ( 26223938 )
2015
50
Primary pulmonary myoepithelial carcinoma in a child: An ambiguous entity. ( 26628769 )
2015

Variations for Myoepithelial Carcinoma

Cosmic variations for Myoepithelial Carcinoma:

9 (show top 50) (show all 160)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM110695 SF3B1 salivary gland,parotid,carcinoma,NS c.1874G>T p.R625L 28
2 COSM10758 TP53 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.659A>G p.Y220C 13
3 COSM12597 PIK3CA salivary gland,parotid,carcinoma,myoepithelial carcinoma c.3145G>C p.G1049R 13
4 COSM13570 PIK3CA salivary gland,parotid,carcinoma,myoepithelial carcinoma c.331A>G p.K111E 13
5 COSM499 HRAS salivary gland,parotid,carcinoma,myoepithelial carcinoma c.182A>G p.Q61R 13
6 COSM496 HRAS salivary gland,parotid,carcinoma,myoepithelial carcinoma c.181C>A p.Q61K 13
7 COSM13168 CTNNB1 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.104T>C p.I35T 13
8 COSM33765 AKT1 salivary gland,parotid,carcinoma,myoepithelial carcinoma c.49G>A p.E17K 13
9 COSM27495 PIK3CA salivary gland,NS,carcinoma,myoepithelial carcinoma c.35G>A p.G12D 12
10 COSM21159 MAP2K4 salivary gland,NS,carcinoma,myoepithelial carcinoma c.752G>A p.S251N 12
11 COSM553 KRAS salivary gland,NS,carcinoma,myoepithelial carcinoma c.182A>T p.Q61L 12
12 COSM498 HRAS salivary gland,NS,carcinoma,myoepithelial carcinoma c.182A>T p.Q61L 12
13 COSM1659071 WASF2 salivary gland,mouth,carcinoma,NS c.15G>T p.T5T 10
14 COSM1658946 VWA5B1 salivary gland,parotid,carcinoma,NS c.1486G>A p.V496I 10
15 COSM5030964 VHL salivary gland,parotid,carcinoma,NS c.319C>T p.R107C 10
16 COSM1659032 TXNRD3 salivary gland,parotid,carcinoma,NS c.412A>G p.K138E 10
17 COSM1659031 TRPV5 salivary gland,mouth,carcinoma,NS c.554A>G p.H185R 10
18 COSM1658989 TP53BP1 salivary gland,mouth,carcinoma,NS c.3854C>G p.T1285S 10
19 COSM10704 TP53 salivary gland,parotid,carcinoma,NS c.844C>T p.R282W 10
20 COSM43797 TP53 salivary gland,parotid,carcinoma,NS c.550G>C p.D184H 10
21 COSM46282 TP53 salivary gland,parotid,carcinoma,NS c.501G>C p.Q167H 10
22 COSM10779 TP53 salivary gland,parotid,carcinoma,NS c.818G>T p.R273L 10
23 COSM44853 TP53 salivary gland,parotid,carcinoma,NS c.661G>A p.E221K 10
24 COSM12193 TP53 salivary gland,parotid,carcinoma,NS c.668C>T p.P223L 10
25 COSM5030954 TP53 salivary gland,parotid,carcinoma,NS c.260C>T p.P87L 10
26 COSM10939 TP53 salivary gland,parotid,carcinoma,NS c.832C>T p.P278S 10
27 COSM10654 TP53 salivary gland,parotid,carcinoma,NS c.637C>T p.R213* 10
28 COSM5030953 TP53 salivary gland,parotid,carcinoma,NS c.38C>T p.P13L 10
29 COSM11564 TP53 salivary gland,parotid,carcinoma,NS c.742C>G p.R248G 10
30 COSM44850 TP53 salivary gland,parotid,carcinoma,NS c.494A>T p.Q165L 10
31 COSM43632 TP53 salivary gland,parotid,carcinoma,NS c.493C>T p.Q165* 10
32 COSM11305 TP53 salivary gland,parotid,carcinoma,NS c.809T>C p.F270S 10
33 COSM44640 TP53 salivary gland,parotid,carcinoma,NS c.782+1G>T p.? 10
34 COSM45307 TP53 salivary gland,parotid,carcinoma,NS c.309C>A p.Y103* 10
35 COSM43687 TP53 salivary gland,parotid,carcinoma,NS c.641A>G p.H214R 10
36 COSM11196 TP53 salivary gland,parotid,carcinoma,NS c.734G>T p.G245V 10
37 COSM43814 TP53 salivary gland,parotid,carcinoma,NS c.587G>C p.R196P 10
38 COSM43596 TP53 salivary gland,parotid,carcinoma,NS c.841G>A p.D281N 10
39 COSM43918 TP53 salivary gland,parotid,carcinoma,NS c.809T>A p.F270Y 10
40 COSM10886 TP53 salivary gland,parotid,carcinoma,NS c.310C>T p.Q104* 10
41 COSM10690 TP53 salivary gland,parotid,carcinoma,NS c.473G>A p.R158H 10
42 COSM46283 TP53 salivary gland,parotid,carcinoma,NS c.569C>A p.P190H 10
43 COSM12013 TP53 salivary gland,parotid,carcinoma,NS c.731G>C p.G244A 10
44 COSM10646 TP53 salivary gland,parotid,carcinoma,NS c.725G>A p.C242Y 10
45 COSM44094 TP53 salivary gland,parotid,carcinoma,NS c.716A>G p.N239S 10
46 COSM1659070 TOMM34 salivary gland,parotid,carcinoma,NS c.555T>A p.P185P 10
47 COSM34221 TIE1 salivary gland,parotid,carcinoma,NS c.2050G>C p.A684P 10
48 COSM1659046 THRA salivary gland,mouth,carcinoma,NS c.1162C>T p.R388W 10
49 COSM1658982 TANGO6 salivary gland,parotid,carcinoma,NS c.352G>C p.G118R 10
50 COSM1658977 STXBP3 salivary gland,parotid,carcinoma,NS c.1275G>C p.R425S 10

Expression for Myoepithelial Carcinoma

Search GEO for disease gene expression data for Myoepithelial Carcinoma.

Pathways for Myoepithelial Carcinoma

Pathways related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.74 ACTC1 KRT18 MUC1 VIM
2
Show member pathways
10.96 GFAP KRT14 KRT18 VIM

GO Terms for Myoepithelial Carcinoma

Cellular components related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.61 ACTC1 EWSR1 GFAP KRT14 KRT18 MUC1
2 intermediate filament GO:0005882 8.92 GFAP KRT14 KRT18 VIM

Biological processes related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.4 ACTC1 VIM
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 MUC1 TP63
3 epithelial cell differentiation GO:0030855 9.13 KRT14 MUC1 TP63
4 intermediate filament organization GO:0045109 9.07 VIM
5 astrocyte development GO:0014002 9.02 VIM
6 Bergmann glial cell differentiation GO:0060020 8.85 VIM
7 intermediate filament-based process GO:0045103 8.32 VIM

Molecular functions related to Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.62 EWSR1 GFAP TP63 VIM
2 scaffold protein binding GO:0097110 9.26 KRT18 VIM
3 structural molecule activity GO:0005198 9.16 KRT18 VIM
4 structural constituent of cytoskeleton GO:0005200 9.13 GFAP KRT14 VIM
5 keratin filament binding GO:1990254 8.62 KRT14 VIM

Sources for Myoepithelial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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