MCID: MYP001
MIFTS: 50

Myoepithelioma malady

Rare diseases, Cancer diseases categories

Summaries for Myoepithelioma

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Myoepithelial carcinoma is a rare malignantĀ tumorĀ that usually occurs in the salivary glands but can also occur in skin and soft tissues. the name of this cancer comes from the appearance of the tumor cells under the microscope.Ā approximately 66% of these tumors occur in the parotid gland. the average age of patients is reported to be 55 years. last updated: 8/18/2009

MalaCards: Myoepithelioma, also known as myoepithelial carcinoma, is related to adenoma and pleomorphic adenoma. An important gene associated with Myoepithelioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways is Nuclear signaling by ERBB4. The compounds orcein and b 723 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and breast, and related mouse phenotype cellular.

Disease Ontology:9 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

Wikipedia:66 Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and... more...

Aliases & Classifications for Myoepithelioma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

myoepithelioma 9 11 46 63
myoepithelial carcinoma 9 44 11
benign myoepithelioma 9 63
malignant myoepithelioma 44
myoepithelioma carcinoma 44
myoepithelial neoplasm 9
myoepithelial adenoma 9


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Disease Ontology9 DOID:2661, DOID:4838
MeSH36 D009208

Related Diseases for Myoepithelioma

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18GeneCards, 19GeneDecks
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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7SERPINB5, ACTC1, KRT14
2pleomorphic adenoma30.6GFAP, SERPINB5, ACTC1, S100B, KRT14
3sarcoma30.1SERPINB5, ACTC1, S100B
4epithelial-myoepithelial carcinoma30.1KRT14
5neurofibromatosis30.0S100B, KRT14
6chordoma29.9GFAP, S100B, KRT14
7adenocarcinoma29.8SERPINB5, ACTC1, KRT14
8adenoid cystic carcinoma29.8SERPINB5, ACTC1, S100B, KRT14
9sinusitis10.3
10clear cell hidradenoma10.1
11hidradenoma10.1
12parachordoma10.1
13glomus tumor10.1ACTC1
14breast adenomyoepithelioma10.1
15choroid plexus papilloma10.1GFAP
16subependymal giant cell astrocytoma10.1GFAP
17giant cell glioblastoma10.1GFAP
18histiocytosis10.1S100B
19vulvovaginitis10.1
20extraskeletal myxoid chondrosarcoma10.1
21familial adenomatous polyposis10.1
22lacrimal gland adenoid cystic carcinoma10.1
23breast myoepitheliosis10.1
24chondrosarcoma10.1
25myxoid chondrosarcoma10.1
26prostatitis10.1
27thyroiditis10.1
28ductal carcinoma in situ10.1KRT14
29spindle cell sarcoma10.1S100B, ACTC1
30cutaneous fibrous histiocytoma10.1ACTC1, S100B
31dermatofibrosarcoma protuberans10.1ACTC1, S100B
32fibrous histiocytoma10.1ACTC1, S100B
33hemangiopericytoma10.1S100B, ACTC1
34malignant mixed mullerian tumor10.0ACTC1, S100B
35ganglioglioma10.0GFAP, S100B
36myxopapillary ependymoma10.0S100B, GFAP
37papillary ependymoma10.0GFAP, S100B
38smooth muscle tumor10.0ACTC1, S100B
39choroid plexus carcinoma10.0S100B, GFAP
40anaplastic ependymoma10.0GFAP, S100B
41malignant peripheral nerve sheath tumor10.0ACTC1, S100B
42gemistocytic astrocytoma10.0GFAP, S100B
43giant cell tumor10.0ACTC1, S100B
44pineocytoma10.0S100B, GFAP
45neurofibroma10.0ACTC1, S100B
46malignant fibroxanthoma10.0ACTC1, S100B
47hemangioblastoma10.0GFAP, S100B
48teratoma10.0GFAP, ACTC1
49ganglioneuroma10.0S100B, GFAP
50gastrointestinal stromal tumor10.0ACTC1, S100B

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Symptoms for Myoepithelioma

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Drugs & Therapeutics for Myoepithelioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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34MalaCards
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MalaCards organs/tissues related to Myoepithelioma:

34
Salivary gland, Skin, Breast, Lung, Tongue, Bone, Liver, Smooth muscle, Colon

Animal Models for Myoepithelioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Myoepithelioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1KRT14, ACTC1, SERPINB5, GFAP

Publications for Myoepithelioma

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53PubMed
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Articles related to Myoepithelioma:

(show top 50)    (show all 256)
idTitleAuthorsYear
1
Establishment and characterization of METON myoepithelioma cell line derived from human palatal myoepithelioma: apical reference to the diverse differentiation potential. (23761224)
2013
2
Parachordoma/myoepithelioma. (22618759)
2013
3
Soft tissue myoepithelioma of the scalp in a 11-year-old girl: a challenging diagnosis. (21615483)
2012
4
Endotracheal myoepithelioma. (21729896)
2011
5
Plasmacytoid myoepithelioma of the palate: case report. (21132566)
2011
6
Oral myoepithelioma of soft tissue origin: report of a new case and literature review. (20955943)
2010
7
Malignant myoepithelioma of the humerus with a satellite lesion: a case report and literature review. (20603404)
2010
8
Malignant vulvar soft tissue myoepithelioma]. (19507572)
2009
9
Recurrent cutaneous myoepithelioma treated using Mohs micrographic surgery: case report and review of the literature. (19125803)
2009
10
Myoepithelioma of the larynx: a case report. (19918450)
2009
11
Benign myoepithelioma of the breast: origin and development. (19490475)
2009
12
Cystic clear cell myoepithelioma of the parotid gland. A case report. (19214604)
2009
13
Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings. (18503832)
2008
14
Malignant myoepithelioma of the parapharyngeal space - a case report. (23120532)
2008
15
Benign myoepithelioma in the interdigital space of the foot. (18212555)
2008
16
Malignant myoepithelioma of the mastoid region - A case report. (23120431)
2007
17
Clear cell malignant myoepithelioma--breast presenting as a fungating mass. (17983409)
2007
18
Plasmacytoid myoepithelioma of the palate in a child. (17397468)
2007
19
Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report. (17041958)
2006
20
A case of middle-ear myoepithelioma. (17141097)
2006
21
Epithelioid myoepithelioma of lacrimal gland. (15568156)
2005
22
Radiotherapy and chemotherapy for myoepithelioma of the sellar region. (15827697)
2005
23
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. (15967613)
2005
24
Mixed tumor or myoepithelioma of the skin? Histologic and immunohistochemical features]. (15192538)
2004
25
Lacrimal gland myoepithelioma in a rhesus macaque (Macaca mulatta). (15357327)
2004
26
Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. (12753168)
2003
27
A case of myoepithelioma arising in an accessory parotid gland. (12385366)
2002
28
Multifocal, nascent, and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: an immunohistochemical and ultrastructural study. (12490978)
2002
29
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. (11710645)
2001
30
Pathology quiz case: plasmacytoid variety of myoepithelioma of minor salivary gland. (11493214)
2001
31
Myoepithelioma of the lung. (10731657)
2000
32
Myoepithelioma arising from the buccal gland: histopathological and immunohistochemical studies. (10808274)
2000
33
Plasmacytoid myoepithelioma of the palate. (10416636)
1999
34
Myoepithelioma of the gingiva. Report of a case. (10397524)
1999
35
Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands. (10394890)
1999
36
Benign myoepithelioma of the skin. (9557794)
1998
37
Unusual case of myoepithelioma associated with adenoid cystic carcinoma of the parotid gland. (7677639)
1995
38
Plasmacytoid myoepithelioma of the laryngeal region: a case report. (7628855)
1995
39
Synchronous parotid myoepithelioma and Warthin's tumor. (7567154)
1995
40
Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study. (7538149)
1995
41
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report. (8191838)
1994
42
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
43
Malignant myoepithelioma after radiation for retinoblastoma. (1329515)
1992
44
Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)
1991
45
Myoepithelioma of the lung. (2821955)
1987
46
Myoepithelioma of the palate in a child. (2423468)
1986
47
Malignant myoepithelioma (myoepithelial carcinoma) of the breast: an ultrastructural and immunocytochemical study. (2413600)
1985
48
Malignant myoepithelioma of the parotid gland. (201361)
1977
49
Myoepithelioma. Review of the literature and report of a case with ultrastructural confirmation. (184407)
1976
50
Myoepithelioma with a leukemoid reaction in BALB-c mice. (4346015)
1972

Variations for Myoepithelioma

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Expression for genes affiliated with Myoepithelioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myoepithelioma

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Pathways for genes affiliated with Myoepithelioma

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51PathCards, 56Reactome
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Pathways related to Myoepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4S100B, GFAP

Compounds for genes affiliated with Myoepithelioma

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Myoepithelioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1orcein469.9ACTC1, S100B
2b 723469.8ACTC1, S100B
3eosin469.8GFAP, S100B
4methanol46 2510.8GFAP, ACTC1
52,3-cyclic nucleotide469.8GFAP, S100B
6dbc-amp469.7GFAP, S100B
72-methoxyethanol469.6ACTC1, KRT14
8cocaine46 1210.5S100B, GFAP
9acth469.4GFAP, S100B
10s 100469.4GFAP, ACTC1, S100B
11reticulin469.4GFAP, ACTC1, S100B
12formaldehyde46 2510.4ACTC1, GFAP, S100B
13choline46 25 1211.3GFAP, S100B
14glycogen46 2510.3GFAP, ACTC1, S100B
15creatinine469.3GFAP, S100B, ACTC1
16matrigel469.2ACTC1, GFAP, SERPINB5
17cytosine46 2510.2SERPINB5, KRT14
18dexamethasone46 52 30 1212.2S100B, ACTC1, GFAP
19imatinib46 52 1211.2ACTC1, S100B
20steroid469.2SERPINB5, S100B, ACTC1
21mucicarmine469.1ACTC1, S100B, KRT14
22oxygen46 2510.0S100B, ACTC1, GFAP
23bromodeoxyuridine469.0KRT14, S100B, GFAP
24methionine469.0S100B, KRT14, GFAP
25arginine468.8KRT14, S100B, GFAP
26cisplatin46 52 62 1211.8GFAP, SERPINB5, KRT14
27threonine468.8GFAP, KRT14, S100B
28testosterone46 62 25 1211.8GFAP, ACTC1, S100B, SERPINB5
29alanine468.8KRT14, S100B, GFAP
30vegf468.7GFAP, SERPINB5, ACTC1, S100B
31cysteine468.6S100B, KRT14, GFAP
32hematoxylin468.6GFAP, ACTC1, S100B, KRT14
33iron46 259.6S100B, KRT14, ACTC1, GFAP
34retinoic acid46 259.5GFAP, ACTC1, S100B, KRT14
35glucose468.5KRT14, ACTC1, GFAP, S100B
36tyrosine468.4KRT14, S100B, GFAP, ACTC1
37calcium46 52 25 1211.4GFAP, ACTC1, S100B, KRT14
38lipid468.3KRT14, SERPINB5, GFAP, S100B
39serine468.3S100B, SERPINB5, GFAP, KRT14
40paraffin468.0SERPINB5, GFAP, KRT14, S100B, ACTC1
41progesterone46 30 62 25 1212.0GFAP, S100B, SERPINB5, KRT14, ACTC1
42estrogen467.9GFAP, KRT14, ACTC1, S100B, SERPINB5

GO Terms for genes affiliated with Myoepithelioma

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17Gene Ontology
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Cellular components related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9S100B, ACTC1, SERPINB5
2intermediate filamentGO:0058828.8GFAP, KRT14
3cytoplasmGO:0057377.4KRT14, S100B, ACTC1, SERPINB5, GFAP

Biological processes related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.4S100B, GFAP

Molecular functions related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.1KRT14, GFAP

Products for genes affiliated with Myoepithelioma

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Sources for Myoepithelioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
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38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
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