MCID: MYP001
MIFTS: 42

Myoepithelioma malady

Rare diseases, Cancer diseases categories

Summaries for Myoepithelioma

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NIH Rare Diseases:41 Myoepithelial carcinoma is a rare malignant tumor that usually occurs in the salivary glands but can also occur in skin and soft tissues. the name of this cancer comes from the appearance of the tumor cells under the microscope. approximately 66% of these tumors occur in the parotid gland. the average age of patients is reported to be 55 years. last updated: 8/18/2009

MalaCards based summary: Myoepithelioma, also known as myoepithelial carcinoma, is related to adenoma and epithelial-myoepithelial carcinoma. An important gene associated with Myoepithelioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways is Nuclear signaling by ERBB4. The compounds orcein and b 723 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and breast, and related mouse phenotype cellular.

Disease Ontology:9 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

Aliases & Classifications for Myoepithelioma

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Myoepithelioma, Aliases & Descriptions:

Name: Myoepithelioma 9 11 43 60
Myoepithelial Carcinoma 9 41 11
Malignant Myoepithelioma 41 60
Benign Myoepithelioma 9 60
 
Myoepithelioma Carcinoma 41
Myoepithelial Neoplasm 9
Myoepithelial Adenoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology9 DOID:2661, DOID:4838
MeSH33 D009208

Related Diseases for Myoepithelioma

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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5SERPINB5, ACTC1, KRT14
2epithelial-myoepithelial carcinoma30.4KRT14
3sarcoma30.3S100B, ACTC1, SERPINB5
4neurofibromatosis30.0KRT14, S100B
5pleomorphic adenoma29.9S100B, GFAP, SERPINB5, ACTC1, KRT14
6chordoma29.8GFAP, KRT14, S100B
7adenocarcinoma29.7ACTC1, KRT14, SERPINB5
8glomus tumor10.4ACTC1
9choroid plexus papilloma10.4GFAP
10subependymal giant cell astrocytoma10.4GFAP
11giant cell glioblastoma10.4GFAP
12histiocytosis10.4S100B
13sinusitis10.3
14ductal carcinoma in situ10.3KRT14
15spindle cell sarcoma10.2ACTC1, S100B
16parachordoma10.2
17cutaneous fibrous histiocytoma10.2S100B, ACTC1
18fibrous histiocytoma10.2S100B, ACTC1
19dermatofibrosarcoma protuberans10.2S100B, ACTC1
20hemangiopericytoma10.2ACTC1, S100B
21malignant mixed mullerian tumor10.2ACTC1, S100B
22ganglioglioma10.2GFAP, S100B
23myxopapillary ependymoma10.2S100B, GFAP
24papillary ependymoma10.2S100B, GFAP
25choroid plexus carcinoma10.2GFAP, S100B
26gemistocytic astrocytoma10.2S100B, GFAP
27smooth muscle tumor10.2S100B, ACTC1
28anaplastic ependymoma10.2GFAP, S100B
29giant cell tumor10.2ACTC1, S100B
30malignant peripheral nerve sheath tumor10.2ACTC1, S100B
31pineocytoma10.2GFAP, S100B
32neurofibroma10.2ACTC1, S100B
33malignant fibroxanthoma10.2ACTC1, S100B
34hemangioblastoma10.2S100B, GFAP
35teratoma10.2GFAP, ACTC1
36ganglioneuroma10.2GFAP, S100B
37gastrointestinal stromal tumor10.2ACTC1, S100B
38leiomyosarcoma10.2ACTC1, S100B
39pilocytic astrocytoma10.2GFAP, S100B
40ependymoma10.2S100B, GFAP
41microphthalmia10.1ACTC1, S100B
42paraganglioma10.1S100B, GFAP
43clear cell hidradenoma10.1
44hidradenoma10.1
45tuberous sclerosis10.1GFAP, S100B
46breast adenomyoepithelioma10.1
47leiomyoma10.1S100B, ACTC1
48papilloma10.1ACTC1, KRT14
49amyotrophic lateral sclerosis 110.1GFAP
50chondrosarcoma10.1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Symptoms for Myoepithelioma

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Drugs & Therapeutics for Myoepithelioma

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Drug clinical trials:

Search ClinicalTrials for Myoepithelioma

Search NIH Clinical Center for Myoepithelioma

Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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MalaCards organs/tissues related to Myoepithelioma:

31
Salivary gland, Skin, Breast, Bone, Lung, Tongue, Smooth muscle, Colon, Kidney, Liver, Thyroid, Ovary, Trachea

Animal Models for Myoepithelioma or affiliated genes

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MGI Mouse Phenotypes related to Myoepithelioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1KRT14, ACTC1, SERPINB5, GFAP

Publications for Myoepithelioma

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Articles related to Myoepithelioma:

(show top 50)    (show all 282)
idTitleAuthorsYear
1
Myoepithelioma of the nose. (24485567)
2014
2
Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall. (24959054)
2014
3
Establishment and characterization of METON myoepithelioma cell line derived from human palatal myoepithelioma: apical reference to the diverse differentiation potential. (23761224)
2013
4
Parachordoma/myoepithelioma. (22618759)
2013
5
Soft tissue myoepithelioma of the scalp in a 11-year-old girl: a challenging diagnosis. (21615483)
2012
6
Endotracheal myoepithelioma. (21729896)
2011
7
Oral myoepithelioma of soft tissue origin: report of a new case and literature review. (20955943)
2010
8
Malignant myoepithelioma of the humerus with a satellite lesion: a case report and literature review. (20603404)
2010
9
Malignant vulvar soft tissue myoepithelioma]. (19507572)
2009
10
Recurrent cutaneous myoepithelioma treated using Mohs micrographic surgery: case report and review of the literature. (19125803)
2009
11
Myoepithelioma of the larynx: a case report. (19918450)
2009
12
Benign myoepithelioma of the breast: origin and development. (19490475)
2009
13
Cystic clear cell myoepithelioma of the parotid gland. A case report. (19214604)
2009
14
Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings. (18503832)
2008
15
Malignant myoepithelioma of the parapharyngeal space - a case report. (23120532)
2008
16
Benign myoepithelioma in the interdigital space of the foot. (18212555)
2008
17
Malignant myoepithelioma of the mastoid region - A case report. (23120431)
2007
18
Clear cell malignant myoepithelioma--breast presenting as a fungating mass. (17983409)
2007
19
Plasmacytoid myoepithelioma of the palate in a child. (17397468)
2007
20
Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report. (17041958)
2006
21
A case of middle-ear myoepithelioma. (17141097)
2006
22
Epithelioid myoepithelioma of lacrimal gland. (15568156)
2005
23
Radiotherapy and chemotherapy for myoepithelioma of the sellar region. (15827697)
2005
24
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. (15967613)
2005
25
Mixed tumor or myoepithelioma of the skin? Histologic and immunohistochemical features]. (15192538)
2004
26
Lacrimal gland myoepithelioma in a rhesus macaque (Macaca mulatta). (15357327)
2004
27
Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. (12753168)
2003
28
A case of myoepithelioma arising in an accessory parotid gland. (12385366)
2002
29
Multifocal, nascent, and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: an immunohistochemical and ultrastructural study. (12490978)
2002
30
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. (11710645)
2001
31
Pathology quiz case: plasmacytoid variety of myoepithelioma of minor salivary gland. (11493214)
2001
32
Myoepithelioma of the lung. (10731657)
2000
33
Myoepithelioma arising from the buccal gland: histopathological and immunohistochemical studies. (10808274)
2000
34
Plasmacytoid myoepithelioma of the palate. (10416636)
1999
35
Myoepithelioma of the gingiva. Report of a case. (10397524)
1999
36
Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands. (10394890)
1999
37
Benign myoepithelioma of the skin. (9557794)
1998
38
Unusual case of myoepithelioma associated with adenoid cystic carcinoma of the parotid gland. (7677639)
1995
39
Plasmacytoid myoepithelioma of the laryngeal region: a case report. (7628855)
1995
40
Synchronous parotid myoepithelioma and Warthin's tumor. (7567154)
1995
41
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report. (8191838)
1994
42
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
43
Malignant myoepithelioma after radiation for retinoblastoma. (1329515)
1992
44
Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)
1991
45
Myoepithelioma of the lung. (2821955)
1987
46
Myoepithelioma of the palate in a child. (2423468)
1986
47
Plasmacytoid myoepithelioma of a minor salivary gland. (2984389)
1985
48
Malignant myoepithelioma of the parotid gland. (201361)
1977
49
Myoepithelioma. Review of the literature and report of a case with ultrastructural confirmation. (184407)
1976
50
Myoepithelioma with a leukemoid reaction in BALB-c mice. (4346015)
1972

Variations for Myoepithelioma

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Expression for genes affiliated with Myoepithelioma

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Search GEO for disease gene expression data for Myoepithelioma.

Pathways for genes affiliated with Myoepithelioma

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Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4S100B, GFAP

Compounds for genes affiliated with Myoepithelioma

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Compounds related to Myoepithelioma according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1orcein439.9S100B, ACTC1
2b 723439.8ACTC1, S100B
3eosin439.8S100B, GFAP
4methanol43 2410.8ACTC1, GFAP
52,3-cyclic nucleotide439.8S100B, GFAP
6dbc-amp439.7S100B, GFAP
72-methoxyethanol439.6ACTC1, KRT14
8cocaine43 1210.5S100B, GFAP
9acth439.4S100B, GFAP
10s 100439.4GFAP, ACTC1, S100B
11reticulin439.4GFAP, ACTC1, S100B
12formaldehyde43 2410.4S100B, ACTC1, GFAP
13choline43 24 1211.3S100B, GFAP
14glycogen43 2410.3S100B, ACTC1, GFAP
15creatinine439.3S100B, ACTC1, GFAP
16matrigel439.2ACTC1, SERPINB5, GFAP
17cytosine43 2410.2KRT14, SERPINB5
18dexamethasone43 49 28 1212.2GFAP, ACTC1, S100B
19imatinib43 49 1211.2S100B, ACTC1
20steroid439.2S100B, ACTC1, SERPINB5
21mucicarmine439.1KRT14, S100B, ACTC1
22oxygen43 2410.0S100B, ACTC1, GFAP
23bromodeoxyuridine439.0GFAP, S100B, KRT14
24methionine439.0GFAP, S100B, KRT14
25arginine438.8GFAP, S100B, KRT14
26cisplatin43 49 59 1211.8GFAP, SERPINB5, KRT14
27threonine438.8KRT14, S100B, GFAP
28testosterone43 59 24 1211.8GFAP, SERPINB5, ACTC1, S100B
29alanine438.8GFAP, S100B, KRT14
30vegf438.7S100B, ACTC1, SERPINB5, GFAP
31cysteine438.6GFAP, S100B, KRT14
32hematoxylin438.6KRT14, S100B, ACTC1, GFAP
33iron43 249.6KRT14, S100B, ACTC1, GFAP
34retinoic acid43 249.5KRT14, S100B, ACTC1, GFAP
35glucose438.5GFAP, ACTC1, S100B, KRT14
36tyrosine438.4GFAP, ACTC1, S100B, KRT14
37calcium43 49 24 1211.4KRT14, S100B, ACTC1, GFAP
38lipid438.3KRT14, S100B, SERPINB5, GFAP
39serine438.3KRT14, S100B, SERPINB5, GFAP
40paraffin438.0GFAP, SERPINB5, ACTC1, S100B, KRT14
41progesterone43 28 59 24 1212.0KRT14, S100B, ACTC1, SERPINB5, GFAP
42estrogen437.9GFAP, SERPINB5, ACTC1, S100B, KRT14

GO Terms for genes affiliated with Myoepithelioma

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Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9S100B, ACTC1, SERPINB5
2intermediate filamentGO:00058828.8GFAP, KRT14
3cytoplasmGO:00057377.4KRT14, S100B, ACTC1, SERPINB5, GFAP

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.4S100B, GFAP

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.1KRT14, GFAP

Products for genes affiliated with Myoepithelioma

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Sources for Myoepithelioma

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3CDC
13ExPASy
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25ICD10
26ICD10 via Orphanet
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28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
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38NCIt
39NDF-RT
42NINDS
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
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61UMLS via Orphanet