MCID: MYP001
MIFTS: 42

Myoepithelioma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Myoepithelioma

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Aliases & Descriptions for Myoepithelioma:

Name: Myoepithelioma 8 10 44 61
Myoepithelial Carcinoma 8 42 10
Malignant Myoepithelioma 42 61
Benign Myoepithelioma 8 61
 
Myoepithelioma Carcinoma 42
Myoepithelial Neoplasm 8
Myoepithelial Adenoma 8


Classifications:



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Disease Ontology8 DOID:2661, DOID:4838
MeSH33 D009208

Summaries for Myoepithelioma

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NIH Rare Diseases:42 Myoepithelial carcinoma is a rare malignant tumor that usually occurs in the salivary glands but can also occur in skin and soft tissues. the name of this cancer comes from the appearance of the tumor cells under the microscope. approximately 66% of these tumors occur in the parotid gland. the average age of patients is reported to be 55 years. last updated: 8/18/2009

MalaCards based summary: Myoepithelioma, also known as myoepithelial carcinoma, is related to adenoma and epithelial-myoepithelial carcinoma. An important gene associated with Myoepithelioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways is Nuclear signaling by ERBB4. The compounds orcein and b 723 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and breast, and related mouse phenotype cellular.

Disease Ontology:8 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

Related Diseases for Myoepithelioma

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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5SERPINB5, ACTC1, KRT14
2epithelial-myoepithelial carcinoma30.4KRT14
3sarcoma30.3S100B, ACTC1, SERPINB5
4neurofibromatosis30.0KRT14, S100B
5pleomorphic adenoma29.9S100B, GFAP, SERPINB5, ACTC1, KRT14
6chordoma29.8GFAP, KRT14, S100B
7adenocarcinoma29.7ACTC1, KRT14, SERPINB5
8glomus tumor10.4ACTC1
9choroid plexus papilloma10.4GFAP
10subependymal giant cell astrocytoma10.4GFAP
11giant cell glioblastoma10.4GFAP
12histiocytosis10.4S100B
13sinusitis10.3
14ductal carcinoma in situ10.3KRT14
15spindle cell sarcoma10.2ACTC1, S100B
16parachordoma10.2
17cutaneous fibrous histiocytoma10.2S100B, ACTC1
18fibrous histiocytoma10.2S100B, ACTC1
19dermatofibrosarcoma protuberans10.2S100B, ACTC1
20hemangiopericytoma10.2ACTC1, S100B
21malignant mixed mullerian tumor10.2ACTC1, S100B
22ganglioglioma10.2GFAP, S100B
23myxopapillary ependymoma10.2S100B, GFAP
24papillary ependymoma10.2S100B, GFAP
25choroid plexus carcinoma10.2GFAP, S100B
26gemistocytic astrocytoma10.2S100B, GFAP
27smooth muscle tumor10.2S100B, ACTC1
28anaplastic ependymoma10.2GFAP, S100B
29giant cell tumor10.2ACTC1, S100B
30malignant peripheral nerve sheath tumor10.2ACTC1, S100B
31pineocytoma10.2GFAP, S100B
32neurofibroma10.2ACTC1, S100B
33malignant fibroxanthoma10.2ACTC1, S100B
34hemangioblastoma10.2S100B, GFAP
35teratoma10.2GFAP, ACTC1
36ganglioneuroma10.2GFAP, S100B
37gastrointestinal stromal tumor10.2ACTC1, S100B
38leiomyosarcoma10.2ACTC1, S100B
39pilocytic astrocytoma10.2GFAP, S100B
40ependymoma10.2S100B, GFAP
41microphthalmia10.1ACTC1, S100B
42paraganglioma10.1S100B, GFAP
43clear cell hidradenoma10.1
44hidradenoma10.1
45tuberous sclerosis10.1GFAP, S100B
46breast adenomyoepithelioma10.1
47leiomyoma10.1S100B, ACTC1
48papilloma10.1ACTC1, KRT14
49amyotrophic lateral sclerosis 110.1GFAP
50chondrosarcoma10.1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Symptoms for Myoepithelioma

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Drugs & Therapeutics for Myoepithelioma

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Drug clinical trials:

Search ClinicalTrials for Myoepithelioma

Search NIH Clinical Center for Myoepithelioma

Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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MalaCards organs/tissues related to Myoepithelioma:

31
Salivary gland, Skin, Breast, Bone, Lung, Tongue, Smooth muscle, Colon, Kidney, Liver, Thyroid, Ovary, Trachea

Animal Models for Myoepithelioma or affiliated genes

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MGI Mouse Phenotypes related to Myoepithelioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1KRT14, ACTC1, SERPINB5, GFAP

Publications for Myoepithelioma

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Articles related to Myoepithelioma:

(show top 50)    (show all 282)
idTitleAuthorsYear
1
Myoepithelioma of the nose. (24485567)
2014
2
Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall. (24959054)
2014
3
Establishment and characterization of METON myoepithelioma cell line derived from human palatal myoepithelioma: apical reference to the diverse differentiation potential. (23761224)
2013
4
Parachordoma/myoepithelioma. (22618759)
2013
5
Soft tissue myoepithelioma of the scalp in a 11-year-old girl: a challenging diagnosis. (21615483)
2012
6
Endotracheal myoepithelioma. (21729896)
2011
7
Oral myoepithelioma of soft tissue origin: report of a new case and literature review. (20955943)
2010
8
Malignant myoepithelioma of the humerus with a satellite lesion: a case report and literature review. (20603404)
2010
9
Malignant vulvar soft tissue myoepithelioma]. (19507572)
2009
10
Recurrent cutaneous myoepithelioma treated using Mohs micrographic surgery: case report and review of the literature. (19125803)
2009
11
Myoepithelioma of the larynx: a case report. (19918450)
2009
12
Benign myoepithelioma of the breast: origin and development. (19490475)
2009
13
Cystic clear cell myoepithelioma of the parotid gland. A case report. (19214604)
2009
14
Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings. (18503832)
2008
15
Malignant myoepithelioma of the parapharyngeal space - a case report. (23120532)
2008
16
Benign myoepithelioma in the interdigital space of the foot. (18212555)
2008
17
Malignant myoepithelioma of the mastoid region - A case report. (23120431)
2007
18
Clear cell malignant myoepithelioma--breast presenting as a fungating mass. (17983409)
2007
19
Plasmacytoid myoepithelioma of the palate in a child. (17397468)
2007
20
Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report. (17041958)
2006
21
A case of middle-ear myoepithelioma. (17141097)
2006
22
Epithelioid myoepithelioma of lacrimal gland. (15568156)
2005
23
Radiotherapy and chemotherapy for myoepithelioma of the sellar region. (15827697)
2005
24
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. (15967613)
2005
25
Mixed tumor or myoepithelioma of the skin? Histologic and immunohistochemical features]. (15192538)
2004
26
Lacrimal gland myoepithelioma in a rhesus macaque (Macaca mulatta). (15357327)
2004
27
Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. (12753168)
2003
28
A case of myoepithelioma arising in an accessory parotid gland. (12385366)
2002
29
Multifocal, nascent, and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: an immunohistochemical and ultrastructural study. (12490978)
2002
30
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. (11710645)
2001
31
Pathology quiz case: plasmacytoid variety of myoepithelioma of minor salivary gland. (11493214)
2001
32
Myoepithelioma of the lung. (10731657)
2000
33
Myoepithelioma arising from the buccal gland: histopathological and immunohistochemical studies. (10808274)
2000
34
Plasmacytoid myoepithelioma of the palate. (10416636)
1999
35
Myoepithelioma of the gingiva. Report of a case. (10397524)
1999
36
Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands. (10394890)
1999
37
Benign myoepithelioma of the skin. (9557794)
1998
38
Unusual case of myoepithelioma associated with adenoid cystic carcinoma of the parotid gland. (7677639)
1995
39
Plasmacytoid myoepithelioma of the laryngeal region: a case report. (7628855)
1995
40
Synchronous parotid myoepithelioma and Warthin's tumor. (7567154)
1995
41
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report. (8191838)
1994
42
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
43
Malignant myoepithelioma after radiation for retinoblastoma. (1329515)
1992
44
Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)
1991
45
Myoepithelioma of the lung. (2821955)
1987
46
Myoepithelioma of the palate in a child. (2423468)
1986
47
Plasmacytoid myoepithelioma of a minor salivary gland. (2984389)
1985
48
Malignant myoepithelioma of the parotid gland. (201361)
1977
49
Myoepithelioma. Review of the literature and report of a case with ultrastructural confirmation. (184407)
1976
50
Myoepithelioma with a leukemoid reaction in BALB-c mice. (4346015)
1972

Variations for Myoepithelioma

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Expression for genes affiliated with Myoepithelioma

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Search GEO for disease gene expression data for Myoepithelioma.

Pathways for genes affiliated with Myoepithelioma

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Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4S100B, GFAP

Compounds for genes affiliated with Myoepithelioma

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Compounds related to Myoepithelioma according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1orcein449.9ACTC1, S100B
2b 723449.8ACTC1, S100B
3eosin449.8GFAP, S100B
4methanol44 2410.8GFAP, ACTC1
52,3-cyclic nucleotide449.8GFAP, S100B
6dbc-amp449.7GFAP, S100B
72-methoxyethanol449.6ACTC1, KRT14
8cocaine44 1110.5S100B, GFAP
9acth449.4GFAP, S100B
10s 100449.4GFAP, ACTC1, S100B
11reticulin449.4GFAP, ACTC1, S100B
12formaldehyde44 2410.4ACTC1, GFAP, S100B
13choline44 24 1111.3GFAP, S100B
14glycogen44 2410.3GFAP, ACTC1, S100B
15creatinine449.3GFAP, S100B, ACTC1
16matrigel449.2ACTC1, GFAP, SERPINB5
17cytosine44 2410.2SERPINB5, KRT14
18dexamethasone44 50 28 1112.2S100B, ACTC1, GFAP
19imatinib44 50 1111.2ACTC1, S100B
20steroid449.2SERPINB5, S100B, ACTC1
21mucicarmine449.1ACTC1, S100B, KRT14
22oxygen44 2410.0S100B, ACTC1, GFAP
23bromodeoxyuridine449.0KRT14, S100B, GFAP
24methionine449.0S100B, KRT14, GFAP
25arginine448.8KRT14, S100B, GFAP
26cisplatin44 50 60 1111.8GFAP, SERPINB5, KRT14
27threonine448.8GFAP, KRT14, S100B
28testosterone44 60 24 1111.8GFAP, ACTC1, S100B, SERPINB5
29alanine448.8KRT14, S100B, GFAP
30vegf448.7GFAP, SERPINB5, ACTC1, S100B
31cysteine448.6S100B, KRT14, GFAP
32hematoxylin448.6GFAP, ACTC1, S100B, KRT14
33iron44 249.6S100B, KRT14, ACTC1, GFAP
34retinoic acid44 249.5GFAP, ACTC1, S100B, KRT14
35glucose448.5KRT14, ACTC1, GFAP, S100B
36tyrosine448.4KRT14, S100B, GFAP, ACTC1
37calcium44 50 24 1111.4GFAP, ACTC1, S100B, KRT14
38lipid448.3KRT14, SERPINB5, GFAP, S100B
39serine448.3S100B, SERPINB5, GFAP, KRT14
40paraffin448.0SERPINB5, GFAP, KRT14, S100B, ACTC1
41progesterone44 28 60 24 1112.0GFAP, S100B, SERPINB5, KRT14, ACTC1
42estrogen447.9GFAP, KRT14, ACTC1, S100B, SERPINB5

GO Terms for genes affiliated with Myoepithelioma

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Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9S100B, ACTC1, SERPINB5
2intermediate filamentGO:00058828.8GFAP, KRT14
3cytoplasmGO:00057377.4KRT14, S100B, ACTC1, SERPINB5, GFAP

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.4S100B, GFAP

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.1KRT14, GFAP

Sources for Myoepithelioma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet