Myoepithelioma malady

Wikipedia: Myoepithelioma of the head and neck, also myoepithelioma, is a tumour of the head and neck that is...⁴⁴ more...

MalaCards: Myoepithelioma, also known as benign myoepithelioma, is related to myoepithelial carcinoma and parachordoma. An important gene associated with Myoepithelioma is S100A1 (S100 calcium binding protein A1), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Cytoskeleton remodeling Keratin filaments. The compounds eosin and orcein have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, skeletal muscle and colon, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: A carcinoma that is composed of outgrowths of myoepithelial cells from a sweat gland.⁶

Aliases & Descriptions:

myoepithelioma 6 8 32 43 benign myoepithelioma 6 43

myoepithelial neoplasm 6 myoepithelial adenoma 6

Diseases related to myoepithelioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 505)

id	Related Disease	Score	Top Affiliating Genes
1	myoepithelial carcinoma	29.6	PCNA, S100A1, TP63, GFAP
2	parachordoma	27.7	VIM, S100B, T, DES
3	pleomorphic adenoma	25.6	PCNA, SERPINB5, VIM, S100A1, S100B, HMGA2
4	chordoma	24.6	VIM, S100A1, S100B, T, EWSR1, TP53
5	adenoma	23.2	KITLG, PCNA, SERPINB5, VIM, S100A1, S100B
6	carcinoma	19.0	KITLG, PCNA, SERPINB5, VIM, S100A1, S100B
7	myxopapillary ependymoma	13.6	S100B, GFAP
8	gliofibroma	13.6	S100B, GFAP
9	langerhans-cell histiocytosis	13.6	S100A1, S100B
10	rhabdoid meningioma	13.6	VIM, GFAP
11	papillary ependymoma	13.6	S100B, GFAP
12	astroblastoma	13.6	VIM, GFAP
13	choroid plexus carcinoma	13.6	S100B, GFAP
14	mixed glioma	13.6	VIM, GFAP
15	cervical cancer	13.5	TP63, KRT14
16	congenital granular cell tumor	13.5	VIM, S100B
17	bednar's tumor	13.5	VIM, S100B
18	anaplastic ependymoma	13.5	S100B, GFAP
19	dermoid cyst of ovary	13.5	VIM, TP63
20	choroid plexus papilloma	13.5	S100B, GFAP
21	melanotic neuroectodermal tumor	13.5	VIM, GFAP
22	anaplastic ganglioglioma	13.5	S100B, ACTC1, GFAP
23	binswanger's disease	13.5	ACTC1, GFAP
24	chondroid chordoma	13.4	VIM, S100A1, S100B
25	lymph node palisaded myofibroblastoma	13.4	VIM, DES
26	myxosarcoma	13.4	VIM, DES
27	infantile digital fibromatosis	13.4	VIM, DES
28	prostate leiomyoma	13.4	VIM, DES
29	retroperitoneal leiomyosarcoma	13.4	S100A1, DES
30	intravenous leiomyomatosis	13.4	ACTC1, DES
31	fibrous meningioma	13.4	S100B, DES
32	meninges sarcoma	13.4	VIM, DES
33	chordoid glioma	13.4	VIM, S100B, GFAP
34	mast-cell sarcoma	13.4	KITLG, VIM
35	malignant peripheral nerve sheath tumor	13.4	VIM, S100A1, S100B
36	mesenchymal chondrosarcoma	13.4	VIM, DES
37	endometrial stromal nodule	13.4	VIM, DES
38	extraosseous ewing's sarcoma	13.4	S100B, EWSR1
39	glomangioma	13.3	S100A1, ACTC1, DES
40	breast malignant phyllodes tumor	13.3	VIM, TP63
41	ganglioneuroma	13.3	S100B, GFAP, THBS1
42	hepatic angiomyolipoma	13.3	VIM, DES
43	neurofibromatosis	13.3	KITLG, S100B, KRT14
44	dermoid cyst	13.3	VIM, TP63
45	endometrial stromal tumor	13.3	VIM, DES
46	pulmonary vein stenosis	13.3	ACTC1, DES
47	malignant giant cell tumor of soft parts	13.3	S100B, ACTC1, DES
48	carney triad	13.3	ACTC1, DES
49	glomangiomyoma	13.3	VIM, ACTC1, DES
50	infantile myofibromatosis	13.3	VIM, ACTC1, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myoepithelioma:

²²

MGI Mouse Phenotypes related to myoepithelioma:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	TP63
2	endocrine/exocrine gland phenotype	MP:0005379	9.6	TP63, HMGA2, EWSR1
3	normal phenotype	MP:0002873	9.2	T, EWSR1, TP63, GFAP
4	limbs/digits/tail phenotype	MP:0005371	8.7	KITLG, T, HMGA2, TP63, THBS1
5	embryogenesis phenotype	MP:0005380	8.6	SERPINB5, VIM, T, TP63, PLAG1, KRT18
6	skeleton phenotype	MP:0005390	8.4	THBS1, TP63, TP53, IL6, KITLG
7	reproductive system phenotype	MP:0005389	8.1	IL6, THBS1, KRT14, NOS2, PLAG1, TP63
8	behavior/neurological phenotype	MP:0005386	7.9	DES, GFAP, NOS2, HMGA2, IL6, T
9	immune system phenotype	MP:0005387	7.6	THBS1, GFAP, KRT14, TP63, TP53, EWSR1
10	renal/urinary system phenotype	MP:0005367	7.6	THBS1, NOS2, TP63, TP53, EWSR1, IL6
11	tumorigenesis	MP:0002006	7.6	THBS1, KRT14, NOS2, TP63, TP53, EWSR1
12	digestive/alimentary phenotype	MP:0005381	7.5	THBS1, GFAP, KRT14, NOS2, TP63, TP53
13	vision/eye phenotype	MP:0005391	7.3	THBS1, GFAP, KRT14, NOS2, PLAG1, TP63
14	muscle phenotype	MP:0005369	6.9	ACTC1, GFAP, THBS1, DES, NOS2, TP63
15	integument phenotype	MP:0010771	6.8	TP63, NOS2, KRT14, THBS1, TP53, HMGA2
16	cardiovascular system phenotype	MP:0005385	6.7	NOS2, ACTC1, GFAP, THBS1, DES, TP63
17	mortality/aging	MP:0010768	6.5	DES, GFAP, KRT14, KRT18, NOS2, TP53
18	homeostasis/metabolism phenotype	MP:0005376	6.3	DES, THBS1, GFAP, ACTC1, KRT14, NOS2
19	cellular phenotype	MP:0005384	6.1	NOS2, KRT14, ACTC1, GFAP, THBS1, TP63
20	growth/size phenotype	MP:0005378	5.8	NOS2, KRT18, ACTC1, GFAP, THBS1, PLAG1

Articles related to myoepithelioma:

(show all 26)

id	Title	Authors	Year	Affiliating Genes
1	Benign myoepithelioma of the lung - a case report and review of the literature. (20180958)	Kourda J.... El Mezni F.	2010	ACTC1
2	Myoepithelioma with melanocytic colonization (melanoc ytic myoepithelioma): a case report. (19515051)	Bernaba B.N.... Cassarino D.S.	2009	S100B
3	Malignant vulvar soft tissue myoepithelioma (19507572)	Mukhina M.S.... Chizh I.A.	2009	KRT18, ACTC1
4	Heterogeneous genetic profiles in soft tissue myoepitheliomas. (18604193)	Hallor K.H.... Mertens F.	2008	HMGA2, PLAG1
5	Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. (18383210)	Brandal P.... Heim S.	2008	EWSR1
6	Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. (18301055)	Tirabosco R.... Flanagan A.M.	2008	T
7	Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland. (16997495)	Sassano P.... Verdino G.	2007	IL6
8	Myoepithelioma of minor salivary gland--an immunohistochemical analysis of four cases. (17143433)	da Silveira E.J.... de Almeida Freitas R.	2006	KRT14
9	Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. (15717758)	Das D.K.... Hossain M.N.	2005	VIM, ACTC1, S100A1
10	Giant myoepithelioma of the upper lip. (16099771)	Shiomori T.... Suzuki H.	2005	VIM, S100A1
11	De novo salivary malignant myoepithelioma: pathologic diagnosis of 19 cases (15454011)	Li J.... Liu A.R.	2004	GFAP
12	Malignant myoepithelioma of the salivary gland--an untypical clinical course. (15619979)	Rzeszutko W.... Sopel M.	2004	VIM, GFAP, ACTC1
13	The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. (11710645)	de Oliveira P.T.... Jaeger R.G.	2001	ACTC1
14	Mixed tumors, myoepitheliomas, and oncocytomas of the soft tissues are likely members of the same family: a clinicopathologic and ultrastructural study. (11758721)	Bisceglia M.... Pasquinelli G.	2001	VIM
15	Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. (9762928)	Nagao T.... Nagao K.	1998	TP53
16	Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma. (9431536)	Jaeger R.G.... de Araujo V.C.	1997	VIM, ACTC1
17	Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: an immunohistochemical analysis. (9083936)	Norberg L.... Dardick I.	1997	PCNA
18	Malignant myoepithelioma of the minor salivary glands arising in a pleomorphic adenoma. (9252699)	Tralongo V.... Daniele E.	1997	S100B, DES
19	Malignant myoepithelioma associated with in situ and invasive ductal carcinoma. Description of a case and review of the literature (9471611)	Scarpellini F.... Foschini M.P.	1997	NOS2
20	Clear cell malignant myoepithelioma of the salivary glands. (8732339)	Michal M.... Leivo I.	1996	S100A1
21	Diagnostic criteria for neoplastic myoepithelial cells in pleomorphic adenomas and myoepitheliomas. Immunocytochemical detection of muscle-specific actin, cytokeratin 14, vimentin, and glial fibrillary acidic protein. (7542546)	Takai Y.... Mori M.	1995	VIM, KRT14, ACTC1
22	Myoepithelioma: definitions and diagnostic criteria. (7483010)	Dardick I.	1995	VIM
23	Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)	Ogawa I.... Nikai H.	1993	PCNA
24	Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. (8380682)	Franquemont D.W.... Mills S.E.	1993	S100B, VIM, GFAP
25	Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)	Ibrahim R.... Sieler M.W.	1991	S100B
26	Myoid gonadal stromal tumor with epithelial different iation (? testicular myoepithelioma). (1661453)	Weidner N.	1991	S100A1

Genes related to myoepithelioma according to GeneCards:

(show all 20)

id	Symbol	Description	Score	GeneCards Section Context
1	S100A1	S100 calcium binding protein A1	11.0	Publications
2	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
3	KRT14	keratin 14	11.0	Publications
4	S100B	S100 calcium binding protein B	11.0	Publications
5	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	11.0
6	VIM	vimentin	11.0	Publications
7	GFAP	glial fibrillary acidic protein	11.0	Publications
8	THBS1	thrombospondin 1	11.0
9	KITLG	KIT ligand	11.0
10	TP63	tumor protein p63	11.0
11	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
12	T	T, brachyury homolog (mouse)	11.0	Publications
13	PLAG1	pleiomorphic adenoma gene 1	11.0	Publications
14	HMGA2	high mobility group AT-hook 2	11.0	Publications
15	DES	desmin	11.0	Publications
16	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
17	KRT18	keratin 18	11.0	Publications
18	PCNA	proliferating cell nuclear antigen	11.0	Publications
19	TP53	tumor protein p53	11.0	Publications
20	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to myoepithelioma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling Neurofilaments10	9.7	VIM, GFAP, DES
2	Cytoskeleton remodeling Keratin filaments10	9.7	KRT14, KRT18, VIM
3	Cytoskeleton remodeling_Keratin filaments41	9.5	VIM, KRT18, KRT14
4	Cytoskeleton remodeling_Neurofilaments41	9.5	VIM, GFAP, DES
5	Selected targets of p5310	9.2	THBS1, TP53, SERPINB5
6	Cytoskeletal Signaling3	9.1	VIM, KRT18, ACTC1, DES
7	Immune response MIF in innate immunity response10	9.0	IL6, TP53, NOS2
8	Immune response_MIF in innate immunity response41	9.0	IL6, TP53, NOS2
9	p53 signaling pathway20	8.9	THBS1, TP53, SERPINB5

Compounds related to myoepithelioma according to GeneDecks:

(show top 50)    (show all 102)

id	Compound	Score	Top Affiliating Genes
1	eosin32	10.2	GFAP, S100B, VIM
2	orcein32	9.8	DES, ACTC1, S100B, VIM
3	2-methoxyethanol32	9.8	TP63, KRT14, ACTC1, S100A1, VIM
4	toluidine32	9.7	DES, KITLG, VIM, S100A1
5	h2o232	9.7	DES, KITLG
6	olopatadine32 9 9	11.6	IL6, S100A1, S100B
7	s 10032	9.6	ACTC1, S100B, VIM, DES, GFAP
8	glucose32	9.4	DES, KRT18, ACTC1, S100B
9	mucicarmine32	9.2	VIM, DES, ACTC1, KRT14, TP63, S100B
10	ganciclovir32 9 9	11.2	THBS1, GFAP, VIM, KITLG
11	methionine32	9.1	GFAP, S100B, KRT14, VIM, THBS1, DES
12	procollagen32	9.1	DES, ACTC1, THBS1, PCNA, VIM
13	arginine32	9.1	TP63, DES, EWSR1, GFAP, S100B, KRT14
14	acetylcholine32 9 18 9	12.0	DES, VIM, S100A1, GFAP, NOS2, S100B
15	reticulin32	9.0	PCNA, VIM, S100B, ACTC1, DES, GFAP
16	biotin32 9 18 9	11.9	PCNA, DES, KITLG, VIM, ACTC1, S100A1
17	matrigel32	8.9	TP63, THBS1, SERPINB5, VIM, KRT18, GFAP
18	butyrate32	8.8	TP53, KRT18, VIM, KITLG, KRT14
19	b 72332	8.8	PCNA, S100B, ACTC1, DES, TP63, S100A1
20	glycogen32 18	9.8	DES, ACTC1, GFAP, S100A1, VIM, S100B
21	estradiol32 9 18 9	11.7	KITLG, DES, GFAP, VIM, PCNA
22	retinoic acid32 42 18	10.7	GFAP, KRT18, EWSR1, IL6, S100B, KITLG
23	cytarabine32 34 9 9	11.5	GFAP, TP53, PCNA, KITLG, VIM
24	dutp32	8.5	KRT18, PCNA, TP53, GFAP
25	formaldehyde32 18	9.5	DES, GFAP, ACTC1, KRT18, S100B, PCNA
26	iron32 18	9.4	DES, GFAP, ACTC1, VIM, S100A1, S100B
27	5-aza-2deoxycytidine32	8.4	KITLG, PCNA, SERPINB5, VIM, TP53, THBS1
28	tamoxifen32 34 9 9	11.3	PCNA, SERPINB5, THBS1, KRT14, TP53, VIM
29	genistein32 9 18 9	11.3	PCNA, VIM, IL6, NOS2, GFAP, KITLG
30	paclitaxel32 34 9 9	11.2	VIM, TP53, THBS1, GFAP, S100B, KITLG
31	lipid32	8.0	VIM, KITLG, THBS1, KRT14, KRT18, IL6
32	cycloheximide32	8.0	VIM, IL6, NOS2, THBS1, GFAP, TP53
33	bromodeoxyuridine32	7.9	PCNA, VIM, TP63, KRT18, GFAP, S100B
34	nitric oxide32 9 18 9	10.9	NOS2, KRT18, SERPINB5, THBS1, DES, S100A1
35	hematoxylin32	7.8	KRT14, KRT18, TP63, S100B, S100A1, VIM
36	cisplatin32 34 9 9	10.8	GFAP, TP63, TP53, KITLG, PCNA, HMGA2
37	lactate32	7.8	KITLG, DES, GFAP, KRT18, IL6, PCNA
38	alanine32	7.7	VIM, THBS1, GFAP, IL6, KRT14, KRT18
39	doxorubicin32 34 9 9	10.7	THBS1, TP63, KRT18, DES, HMGA2, TP53
40	creatinine32	7.7	GFAP, DES, ACTC1, KRT18, VIM, PCNA
41	dexamethasone32 42 34 9 9	11.5	PCNA, VIM, S100B, IL6, THBS1, ACTC1
42	actinomycin d32	7.4	VIM, IL6, HMGA2, TP53, NOS2, DES
43	tyrosine32	7.1	EWSR1, DES, THBS1, KRT14, KRT18, GFAP
44	testosterone32 9 18 9	9.9	TP63, KITLG, PCNA, SERPINB5, VIM, IL6
45	serine32	6.9	KRT14, KRT18, TP53, EWSR1, S100B, VIM
46	thymidine32 18	7.7	GFAP, KRT18, KITLG, PCNA, S100B, IL6
47	progesterone32 42 9 18 9	10.5	DES, THBS1, GFAP, PCNA, ACTC1, KRT14
48	vegf32	5.8	SERPINB5, TP53, GFAP, ACTC1, KRT18, NOS2
49	paraffin32	5.4	SERPINB5, PCNA, KITLG, VIM, S100A1, TP63
50	estrogen32	5.4	IL6, TP53, ACTC1, TP63, NOS2, KRT18

Cellular components related to myoepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	8.9	VIM, KRT18, KRT14, GFAP, DES
2	cytoplasm	GO:005737	5.1	KITLG, GFAP, ACTC1, KRT14, KRT18, NOS2

Biological processes related to myoepithelioma according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	Bergmann glial cell differentiation	GO:060020	10.1	GFAP, VIM
2	intermediate filament organization	GO:045109	10.0	VIM, GFAP
3	astrocyte development	GO:014002	9.7	VIM, GFAP
4	muscle filament sliding	GO:030049	9.6	DES, ACTC1, VIM
5	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.8	KITLG, IL6, TP53
6	base-excision repair	GO:006284	8.7	PCNA, HMGA2, TP53
7	negative regulation of apoptotic process	GO:043066	8.1	IL6, HMGA2, TP53, KRT18, THBS1

Molecular functions related to myoepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	S100 protein binding	GO:044548	10.1	S100A1, S100B
2	structural constituent of cytoskeleton	GO:005200	9.3	DES, GFAP, KRT14, VIM
3	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	8.7	HMGA2, TP53, TP63
4	identical protein binding	GO:042802	7.9	PCNA, THBS1, TP63, TP53, S100B, S100A1
5	protein binding	GO:005515	5.1	TP63, NOS2, KRT18, KRT14, THBS1, DES