MCID: MYP001
MIFTS: 51

Myoepithelioma malady

Rare diseases, Cancer diseases categories
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Summaries for Myoepithelioma

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NIH Rare Diseases:42 Myoepithelial carcinoma is a rare malignant tumor that usually occurs in the salivary glands but can also occur in skin and soft tissues. the name of this cancer comes from the appearance of the tumor cells under the microscope. approximately 66% of these tumors occur in the parotid gland. the average age of patients is reported to be 55 years. last updated: 8/18/2009

MalaCards based summary: Myoepithelioma, also known as myoepithelial carcinoma, is related to adenoma and epithelial-myoepithelial carcinoma. An important gene associated with Myoepithelioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways is Nuclear signaling by ERBB4. The compounds orcein and b 723 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and breast, and related mouse phenotype cellular.

Disease Ontology:8 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

Wikipedia:65 Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and... more...

Aliases & Classifications for Myoepithelioma

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Myoepithelioma, Aliases & Descriptions:

Name: Myoepithelioma 8 10 44 62
Myoepithelial Carcinoma 8 42 10
Malignant Myoepithelioma 42 62
Myoepithelial Neoplasm 8 62
 
Benign Myoepithelioma 8 62
Myoepithelial Adenoma 8 62
Myoepithelioma Carcinoma 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


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Disease Ontology8 DOID:2661, DOID:4838
MeSH34 D009208

Related Diseases for Myoepithelioma

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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5SERPINB5, ACTC1, KRT14
2epithelial-myoepithelial carcinoma30.4KRT14
3sarcoma30.3SERPINB5, ACTC1, S100B
4neurofibromatosis30.0S100B, KRT14
5pleomorphic adenoma29.9GFAP, SERPINB5, ACTC1, S100B, KRT14
6chordoma29.8GFAP, S100B, KRT14
7adenocarcinoma29.7SERPINB5, ACTC1, KRT14
8choroid plexus papilloma10.4GFAP
9subependymal giant cell astrocytoma10.4GFAP
10giant cell glioblastoma10.4GFAP
11histiocytosis10.4S100B
12sinusitis10.3
13ductal carcinoma in situ10.3KRT14
14spindle cell sarcoma10.2S100B, ACTC1
15cutaneous fibrous histiocytoma10.2ACTC1, S100B
16dermatofibrosarcoma protuberans10.2ACTC1, S100B
17fibrous histiocytoma10.2ACTC1, S100B
18parachordoma10.2
19hemangiopericytoma10.2S100B, ACTC1
20malignant mixed mullerian tumor10.2ACTC1, S100B
21ganglioglioma10.2GFAP, S100B
22myxopapillary ependymoma10.2S100B, GFAP
23papillary ependymoma10.2GFAP, S100B
24smooth muscle tumor10.2ACTC1, S100B
25choroid plexus carcinoma10.2S100B, GFAP
26anaplastic ependymoma10.2GFAP, S100B
27malignant peripheral nerve sheath tumor10.2ACTC1, S100B
28gemistocytic astrocytoma10.2GFAP, S100B
29giant cell tumor10.2ACTC1, S100B
30pineocytoma10.2S100B, GFAP
31neurofibroma10.2ACTC1, S100B
32malignant fibroxanthoma10.2ACTC1, S100B
33hemangioblastoma10.2GFAP, S100B
34teratoma10.2GFAP, ACTC1
35ganglioneuroma10.2S100B, GFAP
36gastrointestinal stromal tumor10.2ACTC1, S100B
37leiomyosarcoma10.2S100B, ACTC1
38pilocytic astrocytoma10.2S100B, GFAP
39ependymoma10.2S100B, GFAP
40microphthalmia10.2S100B, ACTC1
41paraganglioma10.1GFAP, S100B
42clear cell hidradenoma10.1
43tuberous sclerosis10.1S100B, GFAP
44leiomyoma10.1S100B, ACTC1
45papilloma10.1KRT14, ACTC1
46breast adenomyoepithelioma10.1
47amyotrophic lateral sclerosis type 1410.1GFAP
48bladder carcinoma10.1SERPINB5, ACTC1
49hodgkin's lymphoma10.1
50vulvovaginitis10.1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Symptoms for Myoepithelioma

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Drugs & Therapeutics for Myoepithelioma

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Drug clinical trials:

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Search NIH Clinical Center for Myoepithelioma

Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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MalaCards organs/tissues related to Myoepithelioma:

32
Salivary gland, Skin, Breast, Lung, Bone, Tongue, Smooth muscle, Colon, Kidney, Liver, Thyroid, Ovary, Trachea

Animal Models for Myoepithelioma or affiliated genes

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MGI Mouse Phenotypes related to Myoepithelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1KRT14, ACTC1, SERPINB5, GFAP

Publications for Myoepithelioma

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Articles related to Myoepithelioma:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Myoepithelioma of the nose. (24485567)
2014
2
Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall. (24959054)
2014
3
Establishment and characterization of METON myoepithelioma cell line derived from human palatal myoepithelioma: apical reference to the diverse differentiation potential. (23761224)
2013
4
Parachordoma/myoepithelioma. (22618759)
2013
5
Soft tissue myoepithelioma of the scalp in a 11-year-old girl: a challenging diagnosis. (21615483)
2012
6
Endotracheal myoepithelioma. (21729896)
2011
7
Oral myoepithelioma of soft tissue origin: report of a new case and literature review. (20955943)
2010
8
Malignant myoepithelioma of the humerus with a satellite lesion: a case report and literature review. (20603404)
2010
9
Malignant vulvar soft tissue myoepithelioma]. (19507572)
2009
10
Recurrent cutaneous myoepithelioma treated using Mohs micrographic surgery: case report and review of the literature. (19125803)
2009
11
Myoepithelioma of the larynx: a case report. (19918450)
2009
12
Benign myoepithelioma of the breast: origin and development. (19490475)
2009
13
Cystic clear cell myoepithelioma of the parotid gland. A case report. (19214604)
2009
14
Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings. (18503832)
2008
15
Malignant myoepithelioma of the parapharyngeal space - a case report. (23120532)
2008
16
Benign myoepithelioma in the interdigital space of the foot. (18212555)
2008
17
Malignant myoepithelioma of the mastoid region - A case report. (23120431)
2007
18
Clear cell malignant myoepithelioma--breast presenting as a fungating mass. (17983409)
2007
19
Plasmacytoid myoepithelioma of the palate in a child. (17397468)
2007
20
Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report. (17041958)
2006
21
A case of middle-ear myoepithelioma. (17141097)
2006
22
Epithelioid myoepithelioma of lacrimal gland. (15568156)
2005
23
Radiotherapy and chemotherapy for myoepithelioma of the sellar region. (15827697)
2005
24
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. (15967613)
2005
25
Mixed tumor or myoepithelioma of the skin? Histologic and immunohistochemical features]. (15192538)
2004
26
Lacrimal gland myoepithelioma in a rhesus macaque (Macaca mulatta). (15357327)
2004
27
Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. (12753168)
2003
28
A case of myoepithelioma arising in an accessory parotid gland. (12385366)
2002
29
Multifocal, nascent, and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: an immunohistochemical and ultrastructural study. (12490978)
2002
30
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. (11710645)
2001
31
Pathology quiz case: plasmacytoid variety of myoepithelioma of minor salivary gland. (11493214)
2001
32
Myoepithelioma of the lung. (10731657)
2000
33
Myoepithelioma arising from the buccal gland: histopathological and immunohistochemical studies. (10808274)
2000
34
Plasmacytoid myoepithelioma of the palate. (10416636)
1999
35
Myoepithelioma of the gingiva. Report of a case. (10397524)
1999
36
Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands. (10394890)
1999
37
Benign myoepithelioma of the skin. (9557794)
1998
38
Unusual case of myoepithelioma associated with adenoid cystic carcinoma of the parotid gland. (7677639)
1995
39
Plasmacytoid myoepithelioma of the laryngeal region: a case report. (7628855)
1995
40
Synchronous parotid myoepithelioma and Warthin's tumor. (7567154)
1995
41
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report. (8191838)
1994
42
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
43
Malignant myoepithelioma after radiation for retinoblastoma. (1329515)
1992
44
Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)
1991
45
Myoepithelioma of the lung. (2821955)
1987
46
Myoepithelioma of the palate in a child. (2423468)
1986
47
Plasmacytoid myoepithelioma of a minor salivary gland. (2984389)
1985
48
Malignant myoepithelioma of the parotid gland. (201361)
1977
49
Myoepithelioma. Review of the literature and report of a case with ultrastructural confirmation. (184407)
1976
50
Myoepithelioma with a leukemoid reaction in BALB-c mice. (4346015)
1972

Variations for Myoepithelioma

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Expression for genes affiliated with Myoepithelioma

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Expression patterns in normal tissues for genes affiliated with Myoepithelioma

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Pathways for genes affiliated with Myoepithelioma

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Pathways related to Myoepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4S100B, GFAP

Compounds for genes affiliated with Myoepithelioma

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Compounds related to Myoepithelioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1orcein449.9S100B, ACTC1
2b 723449.8ACTC1, S100B
3eosin449.8S100B, GFAP
4methanol44 2410.8ACTC1, GFAP
52,3-cyclic nucleotide449.8S100B, GFAP
6dbc-amp449.7S100B, GFAP
72-methoxyethanol449.6ACTC1, KRT14
8cocaine44 1110.5S100B, GFAP
9acth449.4S100B, GFAP
10s 100449.4GFAP, ACTC1, S100B
11reticulin449.4GFAP, ACTC1, S100B
12formaldehyde44 2410.4S100B, ACTC1, GFAP
13choline44 24 1111.3S100B, GFAP
14glycogen44 2410.3S100B, ACTC1, GFAP
15creatinine449.3S100B, ACTC1, GFAP
16matrigel449.2ACTC1, SERPINB5, GFAP
17cytosine44 2410.2KRT14, SERPINB5
18dexamethasone44 50 28 1112.2GFAP, ACTC1, S100B
19imatinib44 50 1111.2S100B, ACTC1
20steroid449.2S100B, ACTC1, SERPINB5
21mucicarmine449.1KRT14, S100B, ACTC1
22oxygen44 2410.0S100B, ACTC1, GFAP
23bromodeoxyuridine449.0GFAP, S100B, KRT14
24methionine449.0GFAP, S100B, KRT14
25arginine448.8GFAP, S100B, KRT14
26cisplatin44 50 61 1111.8GFAP, SERPINB5, KRT14
27threonine448.8KRT14, S100B, GFAP
28testosterone44 61 24 1111.8GFAP, SERPINB5, ACTC1, S100B
29alanine448.8GFAP, S100B, KRT14
30vegf448.7S100B, ACTC1, SERPINB5, GFAP
31cysteine448.6GFAP, S100B, KRT14
32hematoxylin448.6KRT14, S100B, ACTC1, GFAP
33iron44 249.6KRT14, S100B, ACTC1, GFAP
34retinoic acid44 249.5KRT14, S100B, ACTC1, GFAP
35glucose448.5GFAP, ACTC1, S100B, KRT14
36tyrosine448.4GFAP, ACTC1, S100B, KRT14
37calcium44 50 24 1111.4KRT14, S100B, ACTC1, GFAP
38lipid448.3KRT14, S100B, SERPINB5, GFAP
39serine448.3KRT14, S100B, SERPINB5, GFAP
40paraffin448.0GFAP, SERPINB5, ACTC1, S100B, KRT14
41progesterone44 28 61 24 1112.0KRT14, S100B, ACTC1, SERPINB5, GFAP
42estrogen447.9GFAP, SERPINB5, ACTC1, S100B, KRT14

GO Terms for genes affiliated with Myoepithelioma

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Cellular components related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9S100B, ACTC1, SERPINB5
2intermediate filamentGO:0058828.8GFAP, KRT14
3cytoplasmGO:0057377.4KRT14, S100B, ACTC1, SERPINB5, GFAP

Biological processes related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.4S100B, GFAP

Molecular functions related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.1KRT14, GFAP

Products for genes affiliated with Myoepithelioma

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Sources for Myoepithelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
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46OMIM
47OMIM via Orphanet
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52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet