MCID: MYP001
MIFTS: 42

Myoepithelioma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Myoepithelioma

About this section

Aliases & Descriptions for Myoepithelioma:

Name: Myoepithelioma 10 47 12 65 36
Myoepithelial Carcinoma 10 45 12
Malignant Myoepithelioma 45 65
Benign Myoepithelioma 10 65
 
Myoepithelioma Carcinoma 45
Myoepithelial Neoplasm 10
Myoepithelial Adenoma 10


Classifications:



External Ids:

Disease Ontology10 DOID:2661, DOID:4838
MeSH36 D009208

Summaries for Myoepithelioma

About this section
NIH Rare Diseases:45 Myoepithelial carcinoma is a rare malignant tumor that usually occurs in the salivary glands but can also occur in skin and soft tissues. the name of this cancer comes from the appearance of the tumor cells under the microscope. approximately 66% of these tumors occur in the parotid gland. the average age of patients is reported to be 55 years. last updated: 8/18/2009

MalaCards based summary: Myoepithelioma, also known as myoepithelial carcinoma, is related to adenoma and chordoma. An important gene associated with Myoepithelioma is KRT14 (Keratin 14, Type I), and among its related pathways is Cytoskeleton remodeling Neurofilaments. Affiliated tissues include salivary gland, skin and breast, and related mouse phenotypes are digestive/alimentary and reproductive system.

Disease Ontology:10 A sweat gland neoplasm that is composed of outgrowths of myoepithelial cells from a sweat gland.

Related Diseases for Myoepithelioma

About this section

Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.4ACTC1, VIM
2chordoma30.1GFAP, S100A1, S100B, VIM
3pleomorphic adenoma10.6
4sinusitis10.4
5lymphangiomatosis10.3ACTC1, VIM
6gastric signet ring cell adenocarcinoma10.3ACTC1, VIM
7iodine antenatal infection10.3ACTC1, VIM
8esophageal lipoma10.3ACTC1, VIM
9bladder colonic type adenocarcinoma10.3ACTC1, VIM
10benign multicystic peritoneal mesothelioma10.3ACTC1, VIM
11psoriasis10.3ACTC1, VIM
12body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency10.3S100B, VIM
13hand dermatosis10.3ACTC1, VIM
14hypersomnia10.3S100B, VIM
15necrotizing fasciitis10.3ACTC1, S100A1
16internal hemorrhoid10.3ACTC1, VIM
17beemer ertbruggen syndrome10.3S100B, VIM
18gallbladder endocrine tumor10.3S100B, VIM
19multilocular cystic renal cell carcinoma10.3ACTC1, VIM
20neonatal glycine encephalopathy10.3ACTC1, S100B
21portal hypertension10.3S100B, VIM
22infantile recurrent chronic multifocal osteomyolitis10.3ACTC1, VIM
23prostate adenoid cystic carcinoma10.3ACTC1, VIM
24differentiating neuroblastoma10.3S100B, VIM
25malignant hypertension10.3ACTC1, S100B
26uterine corpus serous adenocarcinoma10.3S100B, VIM
27signet ring basal cell carcinoma10.3ACTC1, S100B
28vulvar clear cell hidradenocarcinoma10.3S100B, VIM
29rift valley fever10.3ACTC1, VIM
30malignant leptomeningeal tumor10.3S100A1, S100B
31microscopic colitis10.3ACTC1, S100B
32anaplastic oligoastrocytoma10.3ACTC1, GFAP
33dendritic cell thymoma10.3ACTC1, VIM
34carotenemia10.3GFAP, VIM
35spindle cell liposarcoma10.3S100B, VIM
36epidemic typhus10.3GFAP, VIM
37graphite pneumoconiosis10.3ACTC1, VIM
38carney complex-trismus-pseudocamptodactyly syndrome10.3ACTC1, VIM
39supine hypotensive syndrome10.3GFAP, VIM
40odontoma10.3S100B, VIM
41large cell acanthoma10.3S100B, VIM
42sarcoma10.3
43lupus - neurological sequelae10.3GFAP, S100B
44glossitis10.3ACTC1, VIM
45lymphoplasmacyte-rich meningioma10.3GFAP, S100B
46fibrous synovial sarcoma10.3S100A1, VIM
47periodontal disease10.3S100B, VIM
48parachordoma10.3
49localized pulmonary fibrosis10.3ACTC1, VIM
50mixed gonadal dysgenesis10.3GFAP, S100B

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Symptoms for Myoepithelioma

About this section

Drugs & Therapeutics for Myoepithelioma

About this section

Drugs for Myoepithelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
imatinibapprovedPhase 2567152459-95-5644241, 5291
Synonyms:
112GI019
152459-95-5
1iep
1xbb
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide methanesulfonate
4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
AC-524
AC1L1K0Z
AKOS000280662
BIDD:GT0047
BRD-K92723993-066-02-9
Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- (9CI)
CCRIS 9076
CGP 57148B
CGP57148
CGP57148B
CHEBI:45783
CHEMBL941
CID5291
Cgp 57148
D08066
DB00619
DB03261
EN002706
FT-0083542
Glamox
Glamox (TN)
 
Gleevec
Glivec
HMS2089D03
I01-1232
Imatinib
Imatinib (INN)
Imatinib Mesylate
Imatinib Methansulfonate
Imatinib [INN:BAN]
Imatinib free base
Imatinibum
Kinome_3724
LS-182208
LS-187106
MolPort-000-883-342
N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
NCGC00159456-02
NCGC00159456-03
NCGC00159456-04
NSC743414
STI
STI 571
STI-571
STI571
STK617705
UNII-BKJ8M8G5HI
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
imatinib
nchembio.117-comp23
nchembio.162-comp5
nchembio.282-comp6
nchembio.83-comp14
sti-571
2lysineNutraceuticalPhase 2, Phase 170

Interventional clinical trials:

idNameStatusNCT IDPhase
1Imatinib Mesylate in Treating Patients With Salivary Gland CancerCompletedNCT00045669Phase 2
2Intensity-Modulated or Proton Radiation Therapy for Sinonasal MalignancyRecruitingNCT01586767Phase 2
3A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial SarcomaRecruitingNCT02601950Phase 2
4A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial SarcomaRecruitingNCT02601937Phase 1

Search NIH Clinical Center for Myoepithelioma


Cochrane evidence based reviews: Myoepithelioma

Genetic Tests for Myoepithelioma

About this section

Anatomical Context for Myoepithelioma

About this section

MalaCards organs/tissues related to Myoepithelioma:

33
Salivary gland, Skin, Breast, Lung, Tongue, Bone, Ovary

Animal Models for Myoepithelioma or affiliated genes

About this section

MGI Mouse Phenotypes related to Myoepithelioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6GFAP, KRT14, POU5F1, SMARCB1, TP63
2MP:00053898.1EWSR1, KRT14, POU5F1, SMARCB1, TP63, VIM
3MP:00053697.7ACTC1, EWSR1, GFAP, S100A1, TP63, VIM
4MP:00028737.4ACTC1, EWSR1, GFAP, POU5F1, S100A1, S100B
5MP:00053846.8ACTC1, EWSR1, GFAP, KRT14, POU5F1, SERPINB5
6MP:00107686.5ACTC1, EWSR1, GFAP, KRT14, POU5F1, SERPINB5

Publications for Myoepithelioma

About this section

Articles related to Myoepithelioma:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
MRI and CT imaging characteristics of myoepithelioma of the parotid gland. (26508793)
2015
2
Myoepithelioma-like Tumors of the Vulvar Region: A Distinctive Group of SMARCB1-deficient Neoplasms. (26171919)
2015
3
Myoepithelioma of the nose. (24485567)
2014
4
Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall. (24959054)
2014
5
Establishment and characterization of METON myoepithelioma cell line derived from human palatal myoepithelioma: apical reference to the diverse differentiation potential. (23761224)
2013
6
Soft tissue myoepithelioma of the scalp in a 11-year-old girl: a challenging diagnosis. (21615483)
2012
7
Endotracheal myoepithelioma. (21729896)
2011
8
Oral myoepithelioma of soft tissue origin: report of a new case and literature review. (20955943)
2010
9
Malignant myoepithelioma of the humerus with a satellite lesion: a case report and literature review. (20603404)
2010
10
Malignant vulvar soft tissue myoepithelioma]. (19507572)
2009
11
Recurrent cutaneous myoepithelioma treated using Mohs micrographic surgery: case report and review of the literature. (19125803)
2009
12
Myoepithelioma of the larynx: a case report. (19918450)
2009
13
Benign myoepithelioma of the breast: origin and development. (19490475)
2009
14
Cystic clear cell myoepithelioma of the parotid gland. A case report. (19214604)
2009
15
Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings. (18503832)
2008
16
Malignant myoepithelioma of the parapharyngeal space - a case report. (23120532)
2008
17
Benign myoepithelioma in the interdigital space of the foot. (18212555)
2008
18
Malignant myoepithelioma of the mastoid region - A case report. (23120431)
2007
19
Clear cell malignant myoepithelioma--breast presenting as a fungating mass. (17983409)
2007
20
Plasmacytoid myoepithelioma of the palate in a child. (17397468)
2007
21
Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report. (17041958)
2006
22
A case of middle-ear myoepithelioma. (17141097)
2006
23
Epithelioid myoepithelioma of lacrimal gland. (15568156)
2005
24
Radiotherapy and chemotherapy for myoepithelioma of the sellar region. (15827697)
2005
25
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. (15967613)
2005
26
Mixed tumor or myoepithelioma of the skin? Histologic and immunohistochemical features]. (15192538)
2004
27
Lacrimal gland myoepithelioma in a rhesus macaque (Macaca mulatta). (15357327)
2004
28
Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. (12753168)
2003
29
A case of myoepithelioma arising in an accessory parotid gland. (12385366)
2002
30
Multifocal, nascent, and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: an immunohistochemical and ultrastructural study. (12490978)
2002
31
The effect of a reconstituted basement membrane (matrigel) on a human salivary gland myoepithelioma cell line. (11710645)
2001
32
Pathology quiz case: plasmacytoid variety of myoepithelioma of minor salivary gland. (11493214)
2001
33
Myoepithelioma of the lung. (10731657)
2000
34
Myoepithelioma arising from the buccal gland: histopathological and immunohistochemical studies. (10808274)
2000
35
Plasmacytoid myoepithelioma of the palate. (10416636)
1999
36
Myoepithelioma of the gingiva. Report of a case. (10397524)
1999
37
Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands. (10394890)
1999
38
Benign myoepithelioma of the skin. (9557794)
1998
39
Unusual case of myoepithelioma associated with adenoid cystic carcinoma of the parotid gland. (7677639)
1995
40
Plasmacytoid myoepithelioma of the laryngeal region: a case report. (7628855)
1995
41
Synchronous parotid myoepithelioma and Warthin's tumor. (7567154)
1995
42
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report. (8191838)
1994
43
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
44
Malignant myoepithelioma after radiation for retinoblastoma. (1329515)
1992
45
Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)
1991
46
Myoepithelioma of the lung. (2821955)
1987
47
Myoepithelioma of the palate in a child. (2423468)
1986
48
Malignant myoepithelioma of the parotid gland. (201361)
1977
49
Myoepithelioma. Review of the literature and report of a case with ultrastructural confirmation. (184407)
1976
50
Myoepithelioma with a leukemoid reaction in BALB-c mice. (4346015)
1972

Variations for Myoepithelioma

About this section

Expression for genes affiliated with Myoepithelioma

About this section
Search GEO for disease gene expression data for Myoepithelioma.

Pathways for genes affiliated with Myoepithelioma

About this section

Pathways related to Myoepithelioma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GFAP, KRT14, VIM

GO Terms for genes affiliated with Myoepithelioma

About this section

Cellular components related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:000588210.2GFAP, KRT14, VIM
2I bandGO:00316749.8ACTC1, S100A1
3cytoplasmGO:00057375.9ACTC1, EWSR1, GFAP, KRT14, POU5F1, S100A1

Biological processes related to Myoepithelioma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament-based processGO:004510310.1GFAP, VIM
2intermediate filament organizationGO:004510910.1GFAP, VIM
3Bergmann glial cell differentiationGO:006002010.0GFAP, VIM
4negative regulation of neuron projection developmentGO:00109779.9GFAP, VIM
5muscle filament slidingGO:00300499.8ACTC1, VIM
6astrocyte developmentGO:00140029.6GFAP, VIM
7blastocyst developmentGO:00018249.4POU5F1, SMARCB1

Molecular functions related to Myoepithelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filament bindingGO:199025410.3KRT14, VIM
2S100 protein bindingGO:00445489.7S100A1, S100B
3structural constituent of cytoskeletonGO:00052009.6GFAP, KRT14, VIM
4identical protein bindingGO:00428027.7EWSR1, S100A1, S100B, TP63, VIM

Sources for Myoepithelioma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet