MCID: MYP001
MIFTS: 57

Myoepithelioma malady

Cancer diseases category

Summaries for Myoepithelioma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Myoepithelial carcinoma is a rare malignant tumor that usually occurs in the salivary glands but can also occur in skin and soft tissues. the name of this cancer comes from the appearance of the tumor cells under the microscope. approximately 66% of these tumors occur in the parotid gland. the average age of patients is reported to be 55 years. last updated: 8/18/2009

MalaCards: Myoepithelioma, also known as myoepithelial carcinoma, is related to adenoma and pleomorphic adenoma. An important gene associated with Myoepithelioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Cytoskeleton remodeling Keratin filaments. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and breast, and related mouse phenotypes are muscle and vision/eye.

Disease Ontology:8 A carcinoma that is composed of outgrowths of myoepithelial cells from a sweat gland.

Wikipedia:63 Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and... more...

Aliases & Classifications for Myoepithelioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

myoepithelioma 8 10 44 60
myoepithelial carcinoma 8 42 10
benign myoepithelioma 8 60
malignant myoepithelioma 42
myoepithelioma carcinoma 42
myoepithelial neoplasm 8
myoepithelial adenoma 8


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Disease Ontology8 DOID:2661, DOID:4838
MeSH34 D009208

Related Diseases for Myoepithelioma

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17GeneCards, 18GeneDecks
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Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7TP63, SERPINB5, ACTC1, KRT14, KRT18, THBS1
2pleomorphic adenoma30.6TP63, SERPINB5, ACTC1, NOS2, KRT14, KRT18
3salivary gland cancer30.0MFSD1
4chondrosarcoma30.0HMGA2, DES, EWSR1, S100A1, S100B, VIM
5sarcoma30.0TP63, SERPINB5, ACTC1, HMGA2, KITLG, DES
6epithelial-myoepithelial carcinoma29.9KRT14
7ductal carcinoma in situ29.9KRT14
8neurofibromatosis29.8KRT14, KITLG, S100B
9retinoblastoma29.8KRT14, KRT18, GFAP, PCNA
10chordoma29.8KRT14, KRT18, GFAP, DES, S100A1, S100B
11adenoid cystic carcinoma29.8TP63, SERPINB5, ACTC1, NOS2, KRT14, PCNA
12adenocarcinoma29.8TP63, SERPINB5, ACTC1, NOS2, KRT14, KRT18
13nasopharynx carcinoma10.3
14breast myoepithelial carcinoma10.2
15laryngeal carcinoma10.2
16breast adenomyoepithelioma10.1
17pleomorphic adenoma carcinoma10.1
18pleomorphic carcinoma10.1
19clear cell hidradenoma10.1
20hidradenoma10.1
21parachordoma10.1
22clear cell adenoma10.0
23maxillary sinus adenoid cystic carcinoma10.0
24familial adenomatous polyposis10.0
25small cell carcinoma10.0
26vulvovaginitis10.0
27extraskeletal myxoid chondrosarcoma10.0
28lacrimal gland adenoid cystic carcinoma10.0
29breast myoepitheliosis10.0
30myxoid chondrosarcoma10.0
31prostatitis10.0
32thyroiditis10.0
33renal oncocytoma10.0S100A1
34craniopharyngioma10.0KRT14
35histiocytosis10.0S100B
36fasciitis10.0ACTC1
37gliosarcoma10.0GFAP
38myocardial infarction10.0S100A1
39herpes simplex10.0THBS1
40giant cell glioblastoma10.0GFAP
41glomerulonephritis10.0NOS2
42retinal detachment10.0GFAP
43neurilemmoma10.0GFAP
44subependymal giant cell astrocytoma10.0GFAP
45multiple system atrophy10.0GFAP
46clear cell ependymoma10.0VIM
47schizophrenia10.0S100B
48fibrous meningioma10.0S100B
49mixed glioma10.0GFAP
50cerebral primitive neuroectodermal tumor10.0EWSR1

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Clinical Features for Myoepithelioma

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Drugs & Therapeutics for Myoepithelioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Myoepithelioma

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Anatomical Context for Myoepithelioma

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32MalaCards
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MalaCards organs/tissues related to Myoepithelioma:

32
Salivary gland, Skin, Breast, Lung, Bone, Tongue, Smooth muscle, Colon, Liver

Animal Models for Myoepithelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myoepithelioma:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.1ACTC1, THBS1, GFAP
2MP:00053919.3VIM, PLAG1, GFAP, THBS1, KRT14
3MP:00053798.8EWSR1, IL6, PLAG1, KITLG, HMGA2
4MP:00053768.8DES, T, KITLG, HMGA2, GFAP, KRT14
5MP:00107718.8S100B, EWSR1, T, IL6, KITLG, HMGA2
6MP:00020068.6EWSR1, IL6, KITLG, THBS1, KRT14, NOS2
7MP:00053908.5T, IL6, KITLG, THBS1, NOS2, TP63
8MP:00053818.4T, IL6, KITLG, GFAP, THBS1, KRT14
9MP:00053898.1EWSR1, T, PCNA, PLAG1, KITLG, THBS1
10MP:00053857.6VIM, S100A1, DES, T, IL6, KITLG
11MP:00053867.4VIM, S100B, S100A1, DES, T, IL6
12MP:00053847.1VIM, EWSR1, PCNA, IL6, KITLG, GFAP
13MP:00053877.0IL6, PCNA, EWSR1, VIM, KITLG, GFAP
14MP:00107686.2IL6, PCNA, T, DES, EWSR1, VIM
15MP:00053786.1TP63, VIM, EWSR1, T, PCNA, IL6

Publications for Myoepithelioma

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50PubMed
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Articles related to Myoepithelioma:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
Cutaneous myoepithelioma arising within hidradenoma of the scalp. (22077442)
2012
2
Endotracheal myoepithelioma. (21729896)
2011
3
Myoepithelioma of the soft palate: a case report giving special attention to the differential diagnosis. (24421986)
2011
4
Malignant vulvar soft tissue myoepithelioma]. (19507572)
2009
5
Cystic clear cell myoepithelioma of the parotid gland. A case report. (19214604)
2009
6
Salivary gland myoepithelioma with focal capsular invasion. (19623529)
2009
7
Malignant myoepithelioma of the palate: a case report with review of the clinicopathological characteristics. (20046429)
2009
8
Myoepithelioma within the carpal tunnel: a case report and review of the literature. (19740441)
2009
9
Bilateral myoepithelioma of the nasopharynx: a case report. (19117709)
2009
10
Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings. (18503832)
2008
11
Benign myoepithelioma in the interdigital space of the foot. (18212555)
2008
12
Intraosseous myoepithelioma of the maxilla: clinicopathologic features and therapeutic considerations. (18355609)
2008
13
Malignant myoepithelioma of cranial dura. (17460467)
2007
14
Cytologic findings in malignant myoepithelioma: a case report and review of the literature. (17250774)
2007
15
Plasmacytoid myoepithelioma of palate: three rare cases and literature review. (17640425)
2007
16
Soft-tissue myoepithelioma of the hypothenar region: a case report. (17482007)
2007
17
A salivary malignant myoepithelioma in a dog. (16310384)
2007
18
Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report. (17041958)
2006
19
Pure malignant myoepitheliomas of the breast: an immunohistochemical study. (16933741)
2006
20
Clinical and pathologic features of malignant myoepithelioma of salivary glands]. (16091174)
2005
21
Pediatric myoepithelioma of the palate. (15983693)
2005
22
Plasmacytoid myoepithelioma of the soft palate: a review of the literature and report of a case with immunohistochemical findings. (16340282)
2005
23
Plasmacytoid variant of myoepithelioma of palate: a case report. (16295482)
2004
24
Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. (12753168)
2003
25
Myoepithelioma of the vulva. (12752221)
2003
26
Multifocal, nascent, and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: an immunohistochemical and ultrastructural study. (12490978)
2002
27
Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells. (11224605)
2001
28
Mixed tumors, myoepitheliomas, and oncocytomas of the soft tissues are likely members of the same family: a clinicopathologic and ultrastructural study. (11758721)
2001
29
Myoepithelioma arising from the buccal gland: histopathological and immunohistochemical studies. (10808274)
2000
30
Cytogenetic analysis of a primary salivary gland myoepithelioma. (10459346)
1999
31
Malignant myoepithelioma of the breast metastasizing to the jaw. (10592056)
1999
32
Imprint cytology of malignant plasmacytoid myoepithelioma of the palate. (9568156)
1998
33
Myoepithelioma of the lacrimal gland. (9400797)
1997
34
Malignant myoepithelioma of the minor salivary glands arising in a pleomorphic adenoma. (9252699)
1997
35
Fine needle aspiration (FNA) appearances of malignant myoepithelioma of the parotid gland. (8911760)
1996
36
Quantitative multivariate analysis of myoepithelioma and myoepithelial carcinoma. (7608581)
1995
37
Myoepithelioma of the retroperitoneum. (7571084)
1995
38
Myoepithelioma: definitions and diagnostic criteria. (7483010)
1995
39
Malignant myoepithelioma of the breast - a case-history and review of literature. (21607491)
1994
40
Salivary-type myxoid myoepithelioma of the sinonasal tract: a potential diagnostic pitfall. (8225249)
1993
41
Malignant myoepithelioma after radiation for retinoblastoma. (1329515)
1992
42
Pathologic quiz case 1. Myoepithelioma (hyaline cell/plasmacytoid variant). (1322677)
1992
43
Myoepithelioma of the lacrimal gland: report of a case with spindle cell morphology. (1329939)
1992
44
Malignant myoepithelioma of minor salivary gland origin. (1329434)
1992
45
Spindle cell myoepithelioma of the nasal cavity. (1846508)
1991
46
Myoepithelioma--new concepts of histology and classification: a light and electron microscopic study. (2544051)
1989
47
Myoepithelioma of the palate in a child. (2423468)
1986
48
Infiltrating myoepithelioma of the breast. (6301299)
1982
49
Plasmacytoid myoepithelioma of the palate. (6259307)
1981
50
Altered cyclic adenosine 3':5'-monophosphate metabolism and enzymatic profiles of a transplantable murine submaxillary gland carcinoma (myoepithelioma). (209890)
1978

Genetic Variations for Myoepithelioma

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Expression for genes affiliated with Myoepithelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myoepithelioma

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Pathways for genes affiliated with Myoepithelioma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 29KEGG
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Pathways related to Myoepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7ACTC1, DES, VIM
29.7VIM, KRT18, KRT14
39.6IL6, NOS2, SERPINB5
49.4NOS2, GFAP, IL6, VIM
59.4ACTC1, KRT18, DES, VIM
69.3VIM, HMGA2, THBS1, SERPINB5, TP63

Compounds for genes affiliated with Myoepithelioma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Myoepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7GFAP
2butyrate4410.6GFAP
3paclitaxel44 49 1112.1GFAP, THBS1, S100B
4glycogen44 2411.0KRT18, ACTC1, GFAP
5matrigel4410.0SERPINB5, ACTC1, THBS1, VIM
6orcein4410.0S100B, DES, ACTC1, VIM
7creatinine449.9ACTC1, KRT18, GFAP, KITLG
8estradiol44 11 2411.8DES, GFAP, VIM
9acetylcholine44 49 28 11 2413.8S100A1, NOS2, GFAP
10s 100449.8GFAP, DES, S100B, VIM, ACTC1
11ganciclovir44 1110.7KITLG, THBS1, VIM
12hydroxyapatite449.6S100B, KITLG, THBS1, VIM
13toluidine449.6DES, S100A1, VIM, KITLG
142-methoxyethanol449.6S100A1, ACTC1, VIM, KRT14, TP63
15olopatadine44 1110.6S100B, S100A1, IL6
16eosin449.4PCNA, S100B, VIM, GFAP
17oxygen44 2410.4KITLG, S100B, DES, NOS2, GFAP
18methionine449.4DES, S100B, KRT14, VIM, GFAP, THBS1
19glucose449.4KITLG, GFAP, THBS1, KRT18, KRT14, ACTC1
20serine449.3EWSR1, S100B, THBS1, DES, GFAP, KRT14
21dmso449.2KRT18, THBS1, KITLG, VIM, TP63
22mucicarmine449.1TP63, VIM, S100B, ACTC1, KRT14, DES
23steroid449.1SERPINB5, DES, KRT18, ACTC1
245-aza-2deoxycytidine448.9SERPINB5, THBS1, PCNA, VIM, KITLG
25reticulin448.9ACTC1, GFAP, PCNA, DES, VIM, S100B
26actinomycin d448.7DES, IL6, NOS2, KRT18, HMGA2, KITLG
27doxorubicin44 49 1110.6DES, HMGA2, VIM, THBS1, NOS2, KITLG
28dexamethasone44 49 28 1111.6S100B, GFAP, PCNA, IL6, KRT18, KITLG
29biotin44 11 2410.6ACTC1, KITLG, PCNA, DES, S100A1, VIM
30formaldehyde44 249.5ACTC1, KRT18, GFAP, PCNA, DES, S100B
31cisplatin44 49 59 1111.5SERPINB5, PCNA, HMGA2, GFAP, KRT14, KITLG
32iron44 249.5KRT14, VIM, GFAP, KRT18, ACTC1, KITLG
33lipid448.5GFAP, KITLG, VIM, S100B, IL6, THBS1
34b 723448.4PCNA, DES, S100A1, S100B, VIM, ACTC1
35genistein44 28 59 2 11 2413.4VIM, PCNA, IL6, GFAP, KITLG, NOS2
36nitric oxide44 11 2410.1S100A1, IL6, S100B, THBS1, KRT18, NOS2
37bromodeoxyuridine448.1KRT14, VIM, TP63, KRT18, GFAP, KITLG
38lactate448.0VIM, KRT18, S100B, PCNA, IL6, KITLG
39arginine448.0DES, GFAP, TP63, NOS2, EWSR1, KRT14
40alanine447.9PCNA, VIM, S100B, IL6, KITLG, GFAP
41cysteine447.9PCNA, THBS1, KRT14, S100B, VIM, DES
42calcium44 49 11 2410.8GFAP, THBS1, KRT14, NOS2, ACTC1, TP63
43thymidine44 248.8THBS1, S100B, IL6, TP63, KRT18, GFAP
44hematoxylin447.7DES, S100A1, PCNA, GFAP, KRT18, ACTC1
45tyrosine447.4KRT18, DES, EWSR1, S100A1, S100B, KRT14
46progesterone44 59 28 11 2411.2S100B, ACTC1, SERPINB5, DES, KRT18, KRT14
47testosterone44 59 11 2410.2THBS1, KITLG, IL6, PCNA, DES, S100B
48vegf447.0TP63, KITLG, VIM, S100B, DES, IL6
49paraffin446.4TP63, SERPINB5, ACTC1, KRT14, KRT18, THBS1
50retinoic acid44 247.2VIM, S100B, S100A1, EWSR1, DES, KITLG

GO Terms for genes affiliated with Myoepithelioma

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16Gene Ontology
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Cellular components related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.9ACTC1, THBS1, VIM
2intermediate filamentGO:0058829.0KRT14, KRT18, GFAP, DES, VIM
3cytoplasmGO:0057376.4PCNA, T, EWSR1, S100B, VIM, KITLG

Biological processes related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.1GFAP, VIM
2intermediate filament organizationGO:04510910.0GFAP, VIM
3astrocyte developmentGO:0140029.7GFAP, VIM
4muscle filament slidingGO:0300499.7ACTC1, DES, VIM
5negative regulation of apoptotic processGO:0430668.8IL6, HMGA2, THBS1, KRT18, TP63

Molecular functions related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.8S100A1, S100B
2structural constituent of cytoskeletonGO:0052009.4VIM, DES, GFAP, KRT14
3identical protein bindingGO:0428027.6TP63, VIM, S100B, S100A1, EWSR1, DES
4protein bindingGO:0055155.8VIM, S100B, S100A1, EWSR1, DES, PCNA

Products for genes affiliated with Myoepithelioma

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Sources for Myoepithelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet