MCID: MYP001
MIFTS: 50

Myoepithelioma malady

Cancer category

Summaries for Myoepithelioma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and... more...

MalaCards: Myoepithelioma, also known as benign myoepithelioma, is related to adenoma and pleomorphic adenoma. An important gene associated with Myoepithelioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Cytoskeleton remodeling Keratin filaments. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are muscle and vision/eye.

Disease Ontology:8 A carcinoma that is composed of outgrowths of myoepithelial cells from a sweat gland.

Aliases & Classifications for Myoepithelioma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

myoepithelioma 8 10 45 61
benign myoepithelioma 8 61
myoepithelial neoplasm 8
myoepithelial adenoma 8


External Ids:

Disease Ontology8 DOID:2661
MeSH35 D009208
SNOMED-CT57 69291002
NCIt40 C40392

Related Diseases for Myoepithelioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Myoepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7TP63, SERPINB5, ACTC1, KRT14, KRT18, THBS1
2pleomorphic adenoma30.7TP63, SERPINB5, ACTC1, NOS2, KRT14, KRT18
3epithelial-myoepithelial carcinoma29.9KRT14
4ductal carcinoma in situ29.9KRT14
5neurofibromatosis29.9KRT14, KITLG, S100B
6adenomas, salivary gland pleomorphic29.9HMGA2, PLAG1, S100B
7adenoid cystic carcinoma29.9TP63, SERPINB5, ACTC1, NOS2, KRT14, PCNA
8adenocarcinoma29.8TP63, SERPINB5, ACTC1, NOS2, KRT14, KRT18
9myoepithelial carcinoma10.5
10breast myoepithelial carcinoma10.3
11breast adenomyoepithelioma10.1
12pleomorphic adenoma carcinoma10.1
13pleomorphic carcinoma10.1
14clear cell hidradenoma10.1
15renal oncocytoma10.0S100A1
16craniopharyngioma10.0KRT14
17histiocytosis10.0S100B
18fasciitis10.0ACTC1
19gliosarcoma10.0GFAP
20myocardial infarction10.0S100A1
21herpes simplex10.0THBS1
22giant cell glioblastoma10.0GFAP
23glomerulonephritis10.0NOS2
24retinal detachment10.0GFAP
25neurilemmoma10.0GFAP
26subependymal giant cell astrocytoma10.0GFAP
27multiple system atrophy10.0GFAP
28clear cell ependymoma10.0VIM
29schizophrenia10.0S100B
30fibrous meningioma10.0S100B
31salivary gland cancer10.0MFSD1
32mixed glioma10.0GFAP
33cerebral primitive neuroectodermal tumor10.0EWSR1
34severe combined immunodeficiency10.0KITLG
35myoma10.0HMGA2
36cholesteatoma10.0KRT14, S100A1
37down syndrome10.0S100A1, S100B
38hemangioma10.0ACTC1, THBS1
39hemangioblastoma10.0GFAP, S100B
40teratoma10.0ACTC1, GFAP
41myeloid leukemia10.0KITLG
42lymphangioleiomyomatosis10.0DES
43infantile myofibromatosis10.0DES
44nephroblastoma10.0EWSR1
45perineurioma10.0S100B, VIM
46peripheral primitive neuroectodermal tumor10.0EWSR1
47langerhans-cell histiocytosis10.0S100A1, S100B
48ischemia10.0NOS2, GFAP
49mastocytosis10.0KITLG
50myxopapillary ependymoma10.0GFAP, S100B

Graphical network of the top 20 diseases related to Myoepithelioma:



Diseases related to myoepithelioma

Clinical Features for Myoepithelioma

Drugs & Therapeutics for Myoepithelioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Myoepithelioma

Drug clinical trials:

Search ClinicalTrials for Myoepithelioma

Search NIH Clinical Center for Myoepithelioma

Search CenterWatch for Myoepithelioma

Genetic Tests for Myoepithelioma

Anatomical Context for Myoepithelioma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Myoepithelioma:

33
Skin, Liver, Tongue, Lung, Smooth muscle, Skeletal muscle, Colon, Salivary gland, Breast, T cells

Animal Models for Myoepithelioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myoepithelioma

Sources:
51PubMed
See all sources

Articles related to Myoepithelioma:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
CD10-positive malignant spindle cell tumor of the lip in a child: a malignant myoepithelioma? (23638234)
2013
2
Myoepithelioma of minor salivary glands - A diagnostic challenge: Report of three cases with varied histomorphology. (24250089)
2013
3
Rapid-developed primary malignant myoepithelioma in the cavernous sinus: a case report. (23642050)
2013
4
Frequent PLAG1 gene rearrangements in skin and soft tissue myoepithelioma with ductal differentiation. (23630011)
2013
5
Malignant myoepithelioma of palate. (23293504)
2012
6
Recurrent extensive plasmacytoid myoepithelioma of the sinonasal cavity. (23826001)
2012
7
PLAG1 expression in mesenchymal tumors: an immunohistochemical study with special emphasis on the pathogenetical distinction between soft tissue myoepithelioma and pleomorphic adenoma of the salivary gland. (22192798)
2012
8
Plasmacytoid myoepithelioma of minor salivary glands: report of case with emphasis in the immunohistochemical findings. (22152025)
2011
9
Oral myoepithelioma of soft tissue origin: report of a new case and literature review. (20955943)
2010
10
Benign myoepithelioma of the breast: origin and development. (19490475)
2009
11
Malignant myoepithelioma of the external auditory canal: a case report. (19196374)
2009
12
Cutaneous myoepithelioma with a plexiform pattern of growth: a case report. (19775394)
2009
13
Radiotherapy in Malignant Myoepithelioma of the Soft Palate - Case Report. (20740173)
2009
14
Myoepithelioma of soft tissue. (19136797)
2009
15
Malignant myoepithelioma in the maxillary sinus: case report and review of the literature. (19331194)
2009
16
Preoperative fine needle aspiration cytologic diagnosis of spindle cell myoepithelioma of the parotid gland: a case report. (18702373)
2008
17
Pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) of the lower eyelid. (18520841)
2008
18
Primary malignant myoepithelioma of the left maxillary sinus: a case report. (18380949)
2008
19
Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. (18301055)
2008
20
Malignant myoepithelioma of the mastoid region - A case report. (23120431)
2007
21
Undifferentiated metastatic carcinoma and myoepithelioma: two rare causes of hypervascular masses of the parapharyngeal space. (17702321)
2007
22
Epithelioid myoepithelioma of lacrimal gland. (15568156)
2005
23
Malignant myoepithelioma of the rhinopharynx: case report. (16148972)
2005
24
Submandibular gland myoepithelioma. (16076718)
2005
25
Giant myoepithelioma of the upper lip. (16099771)
2005
26
Mixed tumor or myoepithelioma of the skin? Histologic and immunohistochemical features]. (15192538)
2004
27
Lacrimal gland myoepithelioma in a rhesus macaque (Macaca mulatta). (15357327)
2004
28
Metastatic myoepithelioma of the breast. (15574167)
2004
29
Cytogenetics of a soft tissue malignant myoepithelioma. (15120917)
2004
30
Epithelial-myoepithelial carcinoma arising from clear cell myoepithelioma of the parotid. (12408351)
2002
31
Myoepithelioma. A case report. (11441802)
2001
32
Malignant myoepithelioma of the tongue base: case report and literature review. (11711820)
2001
33
Myoepithelioma of the lacrimal gland: report of a case with potentially malignant transformation. (10792788)
2000
34
Myoepithelioma of the nasal piriform aperture: CT findings. (10541134)
1999
35
Benign myoepithelioma of the skin. (9557794)
1998
36
Quantitation and localization of cycling tumor cells in pleomorphic adenomas and myoepitheliomas: an immunohistochemical analysis. (9083936)
1997
37
Malignant myoepithelioma of the breast. Case report with immunohistochemical study. (9157829)
1996
38
Malignant myoepithelioma arising in salivary tissue on the masseter muscle: US, CT, and MR findings. (8576461)
1996
39
Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study. (7538149)
1995
40
Benign and malignant myoepithelioma of salivary-gland - an immunohistochemical evaluation. (21556664)
1995
41
Biphasic myoepithelioma of parotid gland with collagenous crystalloids. (8063290)
1994
42
Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI). (7907371)
1993
43
Adenomyoepithelioma (myoepithelioma) of the breast in a male. (8389319)
1993
44
Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study. (1707193)
1991
45
Malignant myoepithelial carcinoma (myoepithelioma) arising in a pleomorphic adenoma of the parotid gland. An immunohistochemical study and review of the literature. (2457198)
1988
46
Myoepithelioma of the lung. (2821955)
1987
47
Myoepithelioma. (2996411)
1985
48
Myoepithelioma of the palate. Histochemical and ultrastructural observations. (4346850)
1973
49
Myoepithelioma of the palate. Report of a case with histochemical and electron microscopic observations. (4357077)
1973
50
Mucopolysaccharides in a case of myoepithelioma; physiopathogenic mechanisms]. (13662765)
1958

Genetic Variations for Myoepithelioma

Expression for genes affiliated with Myoepithelioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myoepithelioma

Search GEO for disease gene expression data for Myoepithelioma.

Pathways for genes affiliated with Myoepithelioma

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Myoepithelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7ACTC1, DES, VIM
29.7VIM, KRT18, KRT14
39.6IL6, NOS2, SERPINB5
49.4NOS2, GFAP, IL6, VIM
59.4ACTC1, KRT18, DES, VIM
69.3VIM, HMGA2, THBS1, SERPINB5, TP63

Compounds for genes affiliated with Myoepithelioma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Myoepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7GFAP
2butyrate4510.6GFAP
3paclitaxel45 50 1112.1S100B, GFAP, THBS1
4glycogen45 2411.0GFAP, KRT18, ACTC1
5matrigel4510.0VIM, THBS1, ACTC1, SERPINB5
6orcein4510.0ACTC1, DES, S100B, VIM
7creatinine459.9KITLG, GFAP, KRT18, ACTC1
8estradiol45 11 2411.8VIM, DES, GFAP
9acetylcholine45 50 29 11 2413.8S100A1, GFAP, NOS2
10s 100459.8VIM, S100B, DES, GFAP, ACTC1
11ganciclovir45 1110.7VIM, KITLG, THBS1
12hydroxyapatite459.6THBS1, KITLG, S100B, VIM
13toluidine459.6VIM, S100A1, DES, KITLG
142-methoxyethanol459.6VIM, S100A1, KRT14, ACTC1, TP63
15olopatadine45 1110.6IL6, S100A1, S100B
16eosin459.4VIM, S100B, PCNA, GFAP
17oxygen45 2410.4S100B, DES, KITLG, GFAP, NOS2
18methionine459.4VIM, S100B, DES, GFAP, THBS1, KRT14
19glucose459.4KITLG, GFAP, THBS1, KRT18, KRT14, ACTC1
20serine459.3S100B, EWSR1, DES, GFAP, THBS1, KRT14
21dmso459.2VIM, KITLG, THBS1, KRT18, TP63
22mucicarmine459.1VIM, S100B, S100A1, DES, KRT14, ACTC1
23steroid459.1SERPINB5, ACTC1, KRT18, DES
245-aza-2deoxycytidine458.9VIM, PCNA, KITLG, THBS1, SERPINB5
25reticulin458.9VIM, S100B, DES, PCNA, GFAP, ACTC1
26actinomycin d458.7VIM, DES, IL6, KITLG, HMGA2, KRT18
27doxorubicin45 50 1110.6VIM, DES, KITLG, HMGA2, THBS1, KRT18
28dexamethasone45 50 29 1111.6S100B, PCNA, IL6, KITLG, GFAP, KRT18
29biotin45 11 2410.6VIM, S100A1, DES, PCNA, KITLG, ACTC1
30formaldehyde45 249.5VIM, S100B, DES, PCNA, GFAP, KRT18
31cisplatin45 50 60 1111.5PCNA, KITLG, HMGA2, GFAP, KRT14, SERPINB5
32iron45 249.5VIM, S100B, S100A1, DES, KITLG, GFAP
33lipid458.4VIM, S100B, IL6, KITLG, SERPINB5, KRT14
34b 723458.4TP63, ACTC1, PCNA, DES, S100A1, S100B
35genistein45 29 60 2 11 2413.4VIM, PCNA, IL6, KITLG, GFAP, THBS1
36nitric oxide45 11 2410.1S100B, S100A1, DES, IL6, KITLG, THBS1
37bromodeoxyuridine458.1S100B, DES, PCNA, KITLG, GFAP, VIM
38lactate458.0VIM, S100B, DES, PCNA, IL6, KITLG
39arginine458.0VIM, S100B, EWSR1, DES, PCNA, GFAP
40alanine457.9VIM, S100B, PCNA, IL6, KITLG, GFAP
41cysteine457.9VIM, S100B, S100A1, DES, PCNA, GFAP
42calcium45 50 11 2410.8S100B, S100A1, EWSR1, DES, KITLG, GFAP
43thymidine45 248.8S100B, DES, PCNA, IL6, KITLG, GFAP
44hematoxylin457.7KRT18, KRT14, ACTC1, TP63, GFAP, PCNA
45tyrosine457.4S100B, S100A1, EWSR1, DES, IL6, KITLG
46progesterone45 60 29 11 2411.2PCNA, DES, S100A1, S100B, VIM, GFAP
47testosterone45 60 11 2410.2IL6, PCNA, DES, S100B, VIM, KITLG
48vegf457.0TP63, SERPINB5, ACTC1, NOS2, KRT18, THBS1
49paraffin456.4VIM, S100B, S100A1, EWSR1, DES, PCNA
50retinoic acid45 247.2PCNA, IL6, KITLG, HMGA2, GFAP, THBS1

GO Terms for genes affiliated with Myoepithelioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.9ACTC1, THBS1, VIM
2intermediate filamentGO:0058829.0KRT14, KRT18, GFAP, DES, VIM
3cytoplasmGO:0057376.4PCNA, T, EWSR1, S100B, VIM, KITLG

Biological processes related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.1GFAP, VIM
2intermediate filament organizationGO:04510910.0GFAP, VIM
3astrocyte developmentGO:0140029.7GFAP, VIM
4muscle filament slidingGO:0300499.7ACTC1, DES, VIM
5negative regulation of apoptotic processGO:0430668.8IL6, HMGA2, THBS1, KRT18, TP63

Molecular functions related to Myoepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.8S100A1, S100B
2structural constituent of cytoskeletonGO:0052009.4VIM, DES, GFAP, KRT14
3identical protein bindingGO:0428027.6TP63, VIM, S100B, S100A1, EWSR1, DES
4protein bindingGO:0055155.8VIM, S100B, S100A1, EWSR1, DES, PCNA

Products for genes affiliated with Myoepithelioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myoepithelioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet