MCID: MYF001
MIFTS: 37

Myofibroma malady

Summaries for Myofibroma

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32MalaCards
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MalaCards: Myofibroma, also known as lipoleiomyoma, is related to liposarcoma and hemangioma. An important gene associated with Myofibroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeleton remodeling Neurofilaments. The compounds 2-methoxyethanol and toluidine have been mentioned in the context of this disorder. Affiliated tissues include bone, smooth muscle and testes.

Aliases & Classifications for Myofibroma

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

myofibroma 8 10 60
lipoleiomyoma 8


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Disease Ontology8 DOID:4386
SNOMED-CT56 128917003, 44598004
MeSH34 D047708

Related Diseases for Myofibroma

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17GeneCards, 18GeneDecks
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Diseases related to Myofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma29.9DES, VIM
2hemangioma29.9ACTC1
3fibrosarcoma29.9VIM, DES, ACTC1
4sarcoma29.9ACTC1, DES, CALD1, VIM
5uterine corpus lipoleiomyoma10.2
6gingivitis10.1
7benign mesenchymoma10.0
8leiomyomatosis10.0
9mesenchymoma10.0
10fasciitis10.0ACTC1
11teratoma10.0ACTC1
12infantile myofibromatosis10.0DES
13adenoma10.0ACTC1
14adenomatoid tumor10.0VIM
15perineurioma10.0VIM
16lymphangioleiomyomatosis10.0DES
17lipoma10.0DES
18epidermolysis bullosa simplex10.0DES
19endometriosis10.0ACTC1
20endometrial stromal nodule10.0CALD1
21neurofibromatosis10.0
22adult syndrome10.0
23complex regional pain syndrome10.0
24vascular cancer10.0CALD1
25myopathy10.0DES
26meningioma10.0VIM
27myoepithelioma10.0VIM, ACTC1
28angiosarcoma10.0ACTC1, VIM
29malignant peripheral nerve sheath tumor10.0VIM, ACTC1
30mesenchymal chondrosarcoma10.0VIM, DES
31alveolar soft part sarcoma10.0VIM, DES
32cutaneous fibrous histiocytoma10.0ACTC1, DES
33adenoid cystic carcinoma10.0ACTC1, VIM
34adenosarcoma10.0DES, ACTC1
35sex cord-gonadal stromal tumor10.0DES, VIM
36chondrosarcoma10.0VIM, DES
37embryonal rhabdomyosarcoma10.0ACTC1, DES
38sertoli cell tumor10.0DES, VIM
39desmoid tumor10.0ACTC1, DES
40medulloblastoma10.0ACTC1, DES
41synovial sarcoma10.0VIM, DES
42neurofibroma10.0ACTC1, VIM
43granular cell tumor10.0VIM, DES
44adenocarcinoma10.0ACTC1, VIM
45noonan syndrome10.0ACTC1, DES
46glomus tumor10.0ACTC1, DES, VIM
47epithelioid leiomyosarcoma10.0VIM, DES, ACTC1
48pseudosarcomatous fibromatosis10.0VIM, DES, ACTC1
49fibromatosis10.0VIM, DES, ACTC1
50spindle cell carcinoma10.0ACTC1, DES, VIM

Graphical network of the top 20 diseases related to Myofibroma:



Diseases related to myofibroma

Clinical Features for Myofibroma

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Drugs & Therapeutics for Myofibroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Myofibroma

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Genetic Tests for Myofibroma

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Anatomical Context for Myofibroma

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32MalaCards
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MalaCards organs/tissues related to Myofibroma:

32
Bone, Smooth muscle, Testes, Colon, Breast, Skin, Testis, Tongue

Animal Models for Myofibroma or affiliated genes

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Publications for Myofibroma

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50PubMed
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Articles related to Myofibroma:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Myofibroma of the tongue: a case suggesting autosomal dominant inheritance. (23850370)
2014
2
Solitary myofibroma of the mandible: an immunohistochemical and ultrastructural study with a review of the literature. (24213519)
2013
3
Congenital myofibroma masquerading as an ulcerated infantile hemangioma in a neonate. (22276856)
2013
4
Solitary myofibroma of the adult mandible: a case report. (23021917)
2013
5
Myofibroma of the oral mucosa: a case report. (22179419)
2012
6
Myofibroma of the mandible in an infant: case report, review of the literature, and discussion. (21958664)
2012
7
Solitary cutaneous myofibroma on the sole: an unusual localization. (22577278)
2012
8
Infantile myofibroma eroding into the frontal bone: a case report and review of its histopathologic differential diagnosis. (22966474)
2012
9
Myofibroma of the mandible: a case report. (23007936)
2012
10
Solitary infantile myofibroma of the skull. (22134330)
2011
11
Solitary orbital myofibroma: clinical, radiographic, and histopathologic findings. A report of two cases. (21780929)
2011
12
Congenital infantile myofibroma causing intrauterine death in a twin. (22674951)
2011
13
Myofibroma of the zygomatic bone in an older child: a case report. (21792782)
2011
14
A large tumor on the scalp of a newborn. Solitary myofibroma. (21182644)
2010
15
Myofibroma of the oral cavity. A rare spindle cell neoplasm. (20038894)
2010
16
Myofibroma of the conjunctiva invading the cornea in infancy. (21214145)
2010
17
Myofibroma of the gingiva: report of a case. (20578664)
2010
18
Infantile myofibroma of the nasal cavity; a case report and review of the literature. (20950870)
2010
19
A case report of solitary, intraosseous, adult-onset myofibroma of the mandible. (22190806)
2010
20
A well-known lesion in an unusual location: infantile myofibroma of the eyelid: a case report and review of literature. (21287484)
2010
21
Multiple adult myofibromas with congenital smooth muscle hamartoma. (19187306)
2009
22
Solitary myofibroma of the skull presenting outside infancy. (18714810)
2008
23
Solitary infantile myofibromatosis (myofibroma) of the skull: a case presentation and histopathological differential diagnosis. (18549297)
2008
24
Myofibroma of the mandible. (19246965)
2008
25
Infantile myofibroma: a case report and review of the literature. (18300734)
2008
26
Oral solitary myofibroma. (18154581)
2008
27
Oral and maxillofacial pathology case of the month. Myofibroma. (18038860)
2007
28
Involuting solitary cutaneous infantile myofibroma and thrombocytopaenia: a previously unreported clinical association. (17950191)
2007
29
Gingival myofibroma in children: report of 4 cases with immunohistochemical findings. (19105330)
2007
30
Solitary orbital infantile myofibroma: a case report and review of the literature. (16814188)
2006
31
Testing your diagnostic skills. Case No. 1: a relatively rare jaw neoplasm called a myofibroma. (17708027)
2006
32
Solitary testicular myofibroma: a case report and review of the literature. (16196524)
2005
33
Soft tissue solitary adult myofibroma in an intervertebral foramen. (15550108)
2004
34
Myofibroma of the cheek: a case report. (15266876)
2004
35
Solitary myofibroma of the eyelid. (14738496)
2004
36
Multiple myofibromas and an epidermal verrucous nevus in a child with neurofibromatosis type 1. (15459537)
2004
37
Infantile myofibroma in a prematurely born twin: a case report. (12869160)
2003
38
Solitary adult myofibroma of the mandible simulating an odontogenic cyst. (12798407)
2003
39
"Infantile" myofibroma of the oral cavity: report of case. (11289185)
2001
40
Myofibroma/myofibromatosis is the most common fibrous proliferation of infancy and childhood. (10889935)
2000
41
Myofibromas presenting in the oral cavity: a series of 9 cases. (10710461)
2000
42
Myofibroma versus infantile fibrosarcoma. (10645416)
1999
43
Solitary intraosseous infantile myofibroma of the orbital roof. (9823360)
1998
44
Solitary cutaneous myofibroma of the glans penis. (8806969)
1996
45
Facial myofibroma of the newborn simulating sarcoma]. (9615114)
1996
46
Adult solitary cutaneous myofibroma: a case report. (8950577)
1996
47
Solitary myofibroma in adults: clinicopathological analysis of a series. (8514276)
1993
48
Solitary cutaneous "infantile" myofibroma in a 49-year-old woman. (2338335)
1990
49
CLINICAL pathologic conference; cystic myofibroma. (14804073)
1951
50
X. Myofibroma of the Large Intestine. (17861846)
1906

Genetic Variations for Myofibroma

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Expression for genes affiliated with Myofibroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myofibroma

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Pathways for genes affiliated with Myofibroma

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome
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Compounds for genes affiliated with Myofibroma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Myofibroma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol449.5VIM, ACTC1
2toluidine449.4DES, VIM
3phalloidin449.4DES, VIM
4gemfibrozil44 28 1111.3DES, VIM
5bezafibrate44 28 1111.3VIM, DES
6acetaldehyde44 28 2411.3VIM, DES
7fenofibrate44 49 1111.3DES, VIM
8ganglioside449.2VIM, DES
9progestin449.2DES, VIM
10azathioprine44 49 2 1112.1DES, VIM
11adriamycin449.1DES, VIM
12dihydrotestosterone44 28 11 2412.0DES, VIM
13actomyosin449.0ACTC1, CALD1, VIM
14orcein448.9ACTC1, DES, VIM
15s 100448.9VIM, DES, ACTC1
16reticulin448.9ACTC1, DES, VIM
17mucicarmine448.9VIM, DES, ACTC1
18b 723448.9ACTC1, DES, VIM
19hematoxylin448.9VIM, DES, ACTC1
20procollagen448.9ACTC1, DES, VIM
21biotin44 11 2410.9VIM, DES, ACTC1
22formaldehyde44 249.9ACTC1, DES, VIM
23glycogen44 249.8ACTC1, DES, VIM
24paraffin448.8VIM, DES, ACTC1
25iron44 249.8ACTC1, DES, VIM
26creatinine448.8ACTC1, DES, VIM
27progesterone44 59 28 11 2412.8VIM, DES, ACTC1
28testosterone44 59 11 2411.7ACTC1, DES, VIM
29bromodeoxyuridine448.7DES, VIM
30vegf448.7VIM, DES, ACTC1
31estrogen448.5VIM, DES, ACTC1
32retinoic acid44 249.4ACTC1, DES, VIM

GO Terms for genes affiliated with Myofibroma

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16Gene Ontology
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Cellular components related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.0ACTC1, VIM
2intermediate filamentGO:0058829.0DES, VIM
3cytosolGO:0058297.7ACTC1, DES, CALD1, VIM

Biological processes related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.1CALD1, VIM
2muscle contractionGO:0069369.0DES, CALD1
3muscle filament slidingGO:0300498.4ACTC1, DES, VIM

Molecular functions related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin bindingGO:0170229.1ACTC1, CALD1
2structural constituent of cytoskeletonGO:0052009.0DES, VIM

Products for genes affiliated with Myofibroma

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Sources for Myofibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet