MCID: MYF001
MIFTS: 37

Myofibroma malady

Summaries for Myofibroma

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32MalaCards
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MalaCards: Myofibroma, also known as lipoleiomyoma, is related to liposarcoma and hemangioma. An important gene associated with Myofibroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeleton remodeling Neurofilaments. The compounds 2-methoxyethanol and toluidine have been mentioned in the context of this disorder. Affiliated tissues include bone, smooth muscle and testes.

Aliases & Classifications for Myofibroma

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

myofibroma 8 10 60
lipoleiomyoma 8


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Disease Ontology8 DOID:4386
SNOMED-CT56 128917003, 44598004
MeSH34 D047708

Related Diseases for Myofibroma

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17GeneCards, 18GeneDecks
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Diseases related to Myofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma29.9DES, VIM
2hemangioma29.9ACTC1
3fibrosarcoma29.9VIM, DES, ACTC1
4sarcoma29.9ACTC1, DES, CALD1, VIM
5uterine corpus lipoleiomyoma10.2
6gingivitis10.1
7benign mesenchymoma10.0
8leiomyomatosis10.0
9mesenchymoma10.0
10fasciitis10.0ACTC1
11teratoma10.0ACTC1
12infantile myofibromatosis10.0DES
13adenoma10.0ACTC1
14adenomatoid tumor10.0VIM
15perineurioma10.0VIM
16lymphangioleiomyomatosis10.0DES
17lipoma10.0DES
18epidermolysis bullosa simplex10.0DES
19endometriosis10.0ACTC1
20endometrial stromal nodule10.0CALD1
21neurofibromatosis10.0
22adult syndrome10.0
23complex regional pain syndrome10.0
24vascular cancer10.0CALD1
25myopathy10.0DES
26meningioma10.0VIM
27myoepithelioma10.0VIM, ACTC1
28angiosarcoma10.0ACTC1, VIM
29malignant peripheral nerve sheath tumor10.0VIM, ACTC1
30mesenchymal chondrosarcoma10.0VIM, DES
31alveolar soft part sarcoma10.0VIM, DES
32cutaneous fibrous histiocytoma10.0ACTC1, DES
33adenoid cystic carcinoma10.0ACTC1, VIM
34adenosarcoma10.0DES, ACTC1
35sex cord-gonadal stromal tumor10.0DES, VIM
36chondrosarcoma10.0VIM, DES
37embryonal rhabdomyosarcoma10.0ACTC1, DES
38sertoli cell tumor10.0DES, VIM
39desmoid tumor10.0ACTC1, DES
40medulloblastoma10.0ACTC1, DES
41synovial sarcoma10.0VIM, DES
42neurofibroma10.0ACTC1, VIM
43granular cell tumor10.0VIM, DES
44adenocarcinoma10.0ACTC1, VIM
45noonan syndrome10.0ACTC1, DES
46glomus tumor10.0ACTC1, DES, VIM
47epithelioid leiomyosarcoma10.0VIM, DES, ACTC1
48pseudosarcomatous fibromatosis10.0VIM, DES, ACTC1
49fibromatosis10.0VIM, DES, ACTC1
50spindle cell carcinoma10.0ACTC1, DES, VIM

Graphical network of the top 20 diseases related to Myofibroma:



Diseases related to myofibroma

Clinical Features for Myofibroma

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Drugs & Therapeutics for Myofibroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myofibroma

Search NIH Clinical Center for Myofibroma

Search CenterWatch for Myofibroma

Genetic Tests for Myofibroma

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Anatomical Context for Myofibroma

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32MalaCards
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MalaCards organs/tissues related to Myofibroma:

32
Bone, Smooth muscle, Testes, Colon, Breast, Skin, Testis, Tongue

Animal Models for Myofibroma or affiliated genes

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Publications for Myofibroma

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50PubMed
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Articles related to Myofibroma:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Myofibroma of the tongue: a case suggesting autosomal dominant inheritance. (23850370)
2014
2
Rapid growing myofibroma of the gingiva: report of a case and review of the literature. (23945519)
2014
3
Submandibular myofibroma: a case report. (23404191)
2013
4
Solitary myofibroma of the mandible: an immunohistochemical and ultrastructural study with a review of the literature. (24213519)
2013
5
Intraosseous myofibroma of mandible: A rarity of jaws: With clinical, radiological, histopathological and immunohistochemical features. (23798845)
2013
6
A case of congenital solitary testicular myofibroma associated with an undescended testis. (23856846)
2013
7
A case of congenital myofibroma of the orbit presenting at birth. (23387453)
2013
8
Solitary myofibroma of the sigmoid colon: case report and review of the literature. (23742153)
2013
9
Myofibroma of the oral mucosa: a case report. (22179419)
2012
10
Solitary cutaneous myofibroma on the sole: an unusual localization. (22577278)
2012
11
Upper airway distress due to an oropharyngeal infantile myofibroma. (21733702)
2012
12
Gingival Myofibroma. A case report. (22455535)
2012
13
Solitary infantile myofibroma of the orbit. (20977698)
2011
14
Clinical pathologic conference case 6: infantile myofibroma. (21892764)
2011
15
Congenital cranio-orbital myofibroma. (21088629)
2011
16
Penile myofibroma occurring in a dorsal hood prepuce. (21168192)
2011
17
Solitary orbital myofibroma: clinical, radiographic, and histopathologic findings. A report of two cases. (21780929)
2011
18
Aggressively recurrent infantile myofibroma of the axilla and shoulder girdle. (20978757)
2011
19
Orbital infantile myofibroma: a case report and clinicopathologic review of 24 cases from the literature. (21512784)
2011
20
Myofibroma of the oral cavity. A rare spindle cell neoplasm. (20038894)
2010
21
Infantile myofibroma of the pharynx presenting with severe upper airway obstruction in a child. (20071800)
2010
22
Myofibroma of the external auditory canal: report of an adult case. (20163056)
2009
23
Adult cutaneous myofibroma. (18187828)
2008
24
Oral solitary myofibroma. (18154581)
2008
25
Solitary myofibroma of the sclera. (17198028)
2007
26
Complex regional pain syndrome after solitary adult myofibroma excision. (17659013)
2007
27
Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues. (17448141)
2007
28
Solitary myofibroma of the breast: a case report. (18306549)
2007
29
Solitary myofibroma of the lumbar vertebra: adult case. (16649043)
2007
30
Central (intraosseous) myofibroma of the mandible: clinical, radiologic, and histopathologic features of a rare lesion. (17150381)
2007
31
Fetal neck myofibroma. (17375646)
2007
32
Myofibroma of the proximal nail fold: an uncommon neoplasm. (16648928)
2006
33
Solitary orbital infantile myofibroma: a case report and review of the literature. (16814188)
2006
34
Testing your diagnostic skills. Case No. 1: a relatively rare jaw neoplasm called a myofibroma. (17708027)
2006
35
Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. (16394283)
2006
36
Solitary infantile myofibroma of the orbital bone. (16181295)
2005
37
Testing your diagnostic skills. Case no. 1: myofibroma. (17632922)
2005
38
Solitary infantile gastrointestinal myofibroma: case report. (16080950)
2005
39
Solitary calvarial myofibroma presenting in adolescence. (16455565)
2005
40
Solitary testicular myofibroma: a case report and review of the literature. (16196524)
2005
41
"Infantile" myofibroma of the oral cavity: report of case. (11289185)
2001
42
Solitary intracranial myofibroma in a child. (10475760)
1999
43
Solitary mucosal "infantile" myofibroma in a 21-year-old man. (10199498)
1999
44
Myofibroma of gingiva: report of a case with immunohistochemical and ultrastructural study. (10709548)
1999
45
Myofibroma versus infantile fibrosarcoma. (10645416)
1999
46
Solitary adult myofibroma of the pinna. (10396567)
1999
47
Solitary intraosseous infantile myofibroma of the orbital roof. (9823360)
1998
48
Cutaneous adult myofibroma: a vascular neoplasm. (8915853)
1996
49
Myofibroma of the mandible. Clinicopathologic study and review of the literature. (7489274)
1995
50
Cutaneous myofibroma. (2587567)
1989

Genetic Variations for Myofibroma

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Expression for genes affiliated with Myofibroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myofibroma

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Pathways for genes affiliated with Myofibroma

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome
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Compounds for genes affiliated with Myofibroma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Myofibroma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol449.5VIM, ACTC1
2toluidine449.4DES, VIM
3phalloidin449.4DES, VIM
4gemfibrozil44 28 1111.3DES, VIM
5bezafibrate44 28 1111.3VIM, DES
6acetaldehyde44 28 2411.3VIM, DES
7fenofibrate44 49 1111.3DES, VIM
8ganglioside449.2VIM, DES
9progestin449.2DES, VIM
10azathioprine44 49 2 1112.1DES, VIM
11adriamycin449.1DES, VIM
12dihydrotestosterone44 28 11 2412.0DES, VIM
13actomyosin449.0ACTC1, CALD1, VIM
14orcein448.9ACTC1, DES, VIM
15s 100448.9VIM, DES, ACTC1
16reticulin448.9ACTC1, DES, VIM
17mucicarmine448.9VIM, DES, ACTC1
18b 723448.9ACTC1, DES, VIM
19hematoxylin448.9VIM, DES, ACTC1
20procollagen448.9ACTC1, DES, VIM
21biotin44 11 2410.9VIM, DES, ACTC1
22formaldehyde44 249.9ACTC1, DES, VIM
23glycogen44 249.8ACTC1, DES, VIM
24paraffin448.8VIM, DES, ACTC1
25iron44 249.8ACTC1, DES, VIM
26creatinine448.8ACTC1, DES, VIM
27progesterone44 59 28 11 2412.8VIM, DES, ACTC1
28testosterone44 59 11 2411.7ACTC1, DES, VIM
29bromodeoxyuridine448.7DES, VIM
30vegf448.7VIM, DES, ACTC1
31estrogen448.5VIM, DES, ACTC1
32retinoic acid44 249.4ACTC1, DES, VIM

GO Terms for genes affiliated with Myofibroma

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16Gene Ontology
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Cellular components related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.0ACTC1, VIM
2intermediate filamentGO:0058829.0DES, VIM
3cytosolGO:0058297.7ACTC1, DES, CALD1, VIM

Biological processes related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.1CALD1, VIM
2muscle contractionGO:0069369.0DES, CALD1
3muscle filament slidingGO:0300498.4ACTC1, DES, VIM

Molecular functions related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin bindingGO:0170229.1ACTC1, CALD1
2structural constituent of cytoskeletonGO:0052009.0DES, VIM

Products for genes affiliated with Myofibroma

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Sources for Myofibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet