MCID: MYF001
MIFTS: 37

Myofibroma malady

Summaries for Myofibroma

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Myofibroma, also known as lipoleiomyoma, is related to infantile myofibromatosis and uterine corpus lipoleiomyoma. An important gene associated with Myofibroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeleton remodeling Neurofilaments. The compounds 2-methoxyethanol and toluidine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and skeletal muscle.

Aliases & Classifications for Myofibroma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT
See all sources

Aliases & Descriptions:

myofibroma 8 10 61
lipoleiomyoma 8


External Ids:

Disease Ontology8 DOID:4386
SNOMED-CT57 128917003, 44598004
MeSH35 D047708

Related Diseases for Myofibroma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Myofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1infantile myofibromatosis29.9DES
2uterine corpus lipoleiomyoma10.3
3benign mesenchymoma10.0
4neurofibromatosis10.0
5adult syndrome10.0
6epidermal nevus10.0
7cervicofacial lymphatic malformation10.0
8congenital smooth muscle hamartoma10.0
9lymphatic malformation10.0
10myopericytoma10.0
11verrucous nevus10.0
12fasciitis10.0ACTC1
13teratoma10.0ACTC1
14hemangioma10.0ACTC1
15adenoma10.0ACTC1
16adenomatoid tumor10.0VIM
17perineurioma10.0VIM
18lymphangioleiomyomatosis10.0DES
19lipoma10.0DES
20epidermolysis bullosa simplex10.0DES
21endometriosis10.0ACTC1
22endometrial stromal nodule10.0CALD1
23vascular cancer10.0CALD1
24myopathy10.0DES
25meningioma10.0VIM
26myoepithelioma10.0VIM, ACTC1
27angiosarcoma10.0ACTC1, VIM
28malignant peripheral nerve sheath tumor10.0VIM, ACTC1
29mesenchymal chondrosarcoma10.0VIM, DES
30liposarcoma10.0DES, VIM
31alveolar soft part sarcoma10.0VIM, DES
32cutaneous fibrous histiocytoma10.0ACTC1, DES
33adenoid cystic carcinoma10.0ACTC1, VIM
34adenosarcoma10.0DES, ACTC1
35sex cord-gonadal stromal tumor10.0DES, VIM
36chondrosarcoma10.0VIM, DES
37embryonal rhabdomyosarcoma10.0ACTC1, DES
38sertoli cell tumor10.0DES, VIM
39desmoid tumor10.0ACTC1, DES
40medulloblastoma10.0ACTC1, DES
41synovial sarcoma10.0VIM, DES
42neurofibroma10.0ACTC1, VIM
43granular cell tumor10.0VIM, DES
44adenocarcinoma10.0ACTC1, VIM
45noonan syndrome10.0ACTC1, DES
46glomus tumor10.0ACTC1, DES, VIM
47epithelioid leiomyosarcoma10.0VIM, DES, ACTC1
48pseudosarcomatous fibromatosis10.0VIM, DES, ACTC1
49fibromatosis10.0VIM, DES, ACTC1
50spindle cell carcinoma10.0ACTC1, DES, VIM

Graphical network of the top 20 diseases related to Myofibroma:



Diseases related to myofibroma

Clinical Features for Myofibroma

Drugs & Therapeutics for Myofibroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Myofibroma

Drug clinical trials:

Search ClinicalTrials for Myofibroma

Search NIH Clinical Center for Myofibroma

Search CenterWatch for Myofibroma

Genetic Tests for Myofibroma

Anatomical Context for Myofibroma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Myofibroma:

33
Spinal cord, Smooth muscle, Skeletal muscle, Small intestine, Colon, Lung, Breast, Skin, Ovary, Testis, Tongue, Fetal lung

Animal Models for Myofibroma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Myofibroma

Sources:
51PubMed
See all sources

Articles related to Myofibroma:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
A case of congenital solitary testicular myofibroma associated with an undescended testis. (23856846)
2013
2
A case of congenital myofibroma of the orbit presenting at birth. (23387453)
2013
3
Myofibroma of the oral mucosa: a case report. (22179419)
2012
4
Myofibroma of the mandible in an infant: case report, review of the literature, and discussion. (21958664)
2012
5
Solitary cutaneous myofibroma on the sole: an unusual localization. (22577278)
2012
6
Solitary infantile myofibroma of the skull. (22134330)
2011
7
A large tumor on the scalp of a newborn. Solitary myofibroma. (21182644)
2010
8
Myofibroma of the oral cavity. A rare spindle cell neoplasm. (20038894)
2010
9
Myofibroma of the conjunctiva invading the cornea in infancy. (21214145)
2010
10
Infantile myofibroma of the pharynx presenting with severe upper airway obstruction in a child. (20071800)
2010
11
Myofibroma of the external auditory canal: report of an adult case. (20163056)
2009
12
Intraosseous myofibroma simulating an odontogenic lesion. (19550103)
2009
13
First-line therapy of generalized infantile myofibromatosis with low-dose vinblastine and methotrexate. (18937326)
2009
14
Giant recurrent infantile myofibromatosis of the leg in a 3 year-old. (19661669)
2009
15
Multicentric non-visceral infantile myofibromatosis causing hip contracture. (19371302)
2009
16
Solitary myofibroma of the skull presenting outside infancy. (18714810)
2008
17
Mediastinal and pulmonary infantile myofibromatosis: an unusual surgical presentation. (18970917)
2008
18
Solitary infantile myofibromatosis (myofibroma) of the skull: a case presentation and histopathological differential diagnosis. (18549297)
2008
19
Infantile myofibromatosis in a three-year-old boy presented as subdural hematoma. (19267113)
2008
20
Oral and maxillofacial pathology case of the month. Myofibroma. (18038860)
2007
21
An enlarging tender nodule on the finger of a 4-year-old boy: an unusual presentation of infantile myofibromatosis. (17637366)
2007
22
Solitary infantile myofibromatosis of the skull. (17553333)
2007
23
Myofibroma of the proximal nail fold: an uncommon neoplasm. (16648928)
2006
24
An historic perspective of infantile myofibromatosis. (17249306)
2006
25
Testing your diagnostic skills. Case No. 1: a relatively rare jaw neoplasm called a myofibroma. (17708027)
2006
26
Infantile myofibromatosis: a most unusual cause of gastric outlet obstruction. (15841368)
2005
27
Solitary testicular myofibroma: a case report and review of the literature. (16196524)
2005
28
Oral myofibromatosis: an unusual cause of gingival overgrowth. (12472999)
2002
29
Solitary infantile myofibromatosis: report of two cases. (12173669)
2002
30
Infantile myofibromatosis of the ovary presenting with ascites. (11807673)
2001
31
Myofibroma/myofibromatosis is the most common fibrous proliferation of infancy and childhood. (10889935)
2000
32
Dermatological presentations of infantile myofibromatosis: a review of 27 cases. (10954986)
2000
33
Infantile myofibromatosis: a case study and review of literature. (10535254)
1999
34
Infantile myofibromatosis identified by fetal ultrasound. (10233284)
1999
35
Head and neck infantile myofibromatosis--a report of three cases. (10628545)
1999
36
Sporadic unifocal infantile myofibromatosis involving the skull. Case report. (10350262)
1999
37
Myofibroma versus infantile fibrosarcoma. (10645416)
1999
38
An unusual presentation of congenital infantile myofibromatosis arising from the interspinous ligament. (9880725)
1998
39
Infantile myofibromatosis with hemangiopericytoma-like features of the tongue: a case study including ultrastructure. (9086537)
1997
40
Infantile myofibromatosis: a cause of vertebra plana. (7611050)
1995
41
Massive apoptosis in infantile myofibromatosis. A putative mechanism of tumor regression. (8129033)
1994
42
Intracranial infantile myofibromatosis. (7931587)
1994
43
Infantile myofibromatosis: report of two cases. (8089373)
1994
44
Infantile myofibromatosis: a cause of severe bone pain in a neonate. (8369903)
1993
45
Solitary congenital fibromatosis (infantile myofibromatosis) of bone. (1928549)
1991
46
Infantile myofibromatosis: diagnosis suggested by fine-needle aspiration biopsy. (2209355)
1990
47
Cutaneous myofibroma. (2587567)
1989
48
Infantile myofibromatosis. (3236168)
1988
49
Solitary nodule on the arm of an infant. Infantile myofibromatosis (IM). (3942412)
1986
50
X. Myofibroma of the Large Intestine. (17861846)
1906

Genetic Variations for Myofibroma

Expression for genes affiliated with Myofibroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myofibroma

Search GEO for disease gene expression data for Myofibroma.

Pathways for genes affiliated with Myofibroma

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 54Reactome
See all sources

Compounds for genes affiliated with Myofibroma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Myofibroma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol459.5VIM, ACTC1
2toluidine459.4DES, VIM
3phalloidin459.4DES, VIM
4gemfibrozil45 29 1111.3DES, VIM
5bezafibrate45 29 1111.3VIM, DES
6acetaldehyde45 29 2411.3VIM, DES
7fenofibrate45 50 1111.3DES, VIM
8ganglioside459.2VIM, DES
9progestin459.2DES, VIM
10azathioprine45 50 2 1112.1DES, VIM
11adriamycin459.1DES, VIM
12dihydrotestosterone45 29 11 2412.0DES, VIM
13actomyosin459.0ACTC1, CALD1, VIM
14orcein458.9ACTC1, DES, VIM
15s 100458.9VIM, DES, ACTC1
16reticulin458.9ACTC1, DES, VIM
17mucicarmine458.9VIM, DES, ACTC1
18b 723458.9ACTC1, DES, VIM
19hematoxylin458.9VIM, DES, ACTC1
20procollagen458.9ACTC1, DES, VIM
21biotin45 11 2410.9VIM, DES, ACTC1
22formaldehyde45 249.9ACTC1, DES, VIM
23glycogen45 249.8ACTC1, DES, VIM
24paraffin458.8VIM, DES, ACTC1
25iron45 249.8ACTC1, DES, VIM
26creatinine458.8ACTC1, DES, VIM
27progesterone45 60 29 11 2412.8VIM, DES, ACTC1
28testosterone45 60 11 2411.7ACTC1, DES, VIM
29bromodeoxyuridine458.7DES, VIM
30vegf458.7VIM, DES, ACTC1
31estrogen458.5VIM, DES, ACTC1
32retinoic acid45 249.4ACTC1, DES, VIM

GO Terms for genes affiliated with Myofibroma

Sources:
16Gene Ontology
See all sources

Cellular components related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.0ACTC1, VIM
2intermediate filamentGO:0058829.0DES, VIM
3cytosolGO:0058297.7ACTC1, DES, CALD1, VIM

Biological processes related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.1CALD1, VIM
2muscle contractionGO:0069369.0DES, CALD1
3muscle filament slidingGO:0300498.4ACTC1, DES, VIM

Molecular functions related to Myofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin bindingGO:0170229.1ACTC1, CALD1
2structural constituent of cytoskeletonGO:0052009.0DES, VIM

Products for genes affiliated with Myofibroma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myofibroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet