MCID: MYF001
MIFTS: 37

Myofibroma malady

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Myofibroma

Aliases & Descriptions for Myofibroma:

Name: Myofibroma 12 42 14 69
Solitary Myofibromatosis 69
Uterine Fibroids 69
Lipoleiomyoma 12
Myolipoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4386
MeSH 42 D047708
SNOMED-CT 64 128917003 44598004
UMLS 69 C1266121

Summaries for Myofibroma

MalaCards based summary : Myofibroma, also known as solitary myofibromatosis, is related to uterine corpus lipoleiomyoma and craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development, and has symptoms including pelvic pain An important gene associated with Myofibroma is MB (Myoglobin). The drugs Desogestrel and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and smooth muscle, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Myofibroma

Diseases related to Myofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 uterine corpus lipoleiomyoma 11.9
2 craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development 10.9
3 mixed type rhabdomyosarcoma 10.2 DES MB
4 glaucoma iridogoniodysgenesia 10.2 DES MB
5 verruciform xanthoma of skin 10.2 DES MB
6 intrahepatic bile duct cystadenoma 10.2 DES MB
7 transitional cell carcinoma 10.2 DES MB
8 ovarian cystadenoma 10.2 DES MB
9 bile duct rhabdomyosarcoma 10.2 DES MB
10 extracutaneous mastocytoma 10.2 DES MB
11 bone deterioration disease 10.2 DES MB
12 rectal neoplasm 10.2 DES MB
13 t-cell childhood lymphoblastic lymphoma 10.2 DES MB
14 oral erosive lichen 10.2 DES F13A1
15 van regemorter pierquin vamos syndrome 10.2 DES MB
16 congenital myasthenic syndrome 10.2 DES F13A1
17 childhood medulloblastoma 10.2 DES MB
18 spindle cell rhabdomyosarcoma 10.2 DES MB
19 cavernous sinus meningioma 10.2 DES F13A1
20 dyslexia 10.2 DES F13A1
21 hyperpituitarism 10.2 DES MB
22 sensory organ benign neoplasm 10.2 CD1A MB
23 rectum lymphoma 10.2 CD1A MB
24 house allergic alveolitis 10.2 DES F13A1
25 tinea favosa 10.1 DES F13A1
26 alopecia universalis onychodystrophy vitiligo 10.1 CD1A F13A1
27 mediastinum sarcoma 10.1 DES MB
28 diarrhea, chronic, with villous atrophy 10.1 DES F13A1
29 prostate rhabdomyosarcoma 10.1 DES MB
30 advanced sleep-phase syndrome, familial, 2 10.1 DES MB
31 caroli disease 10.1 DES F13A1
32 juvenile xanthogranuloma 10.1 DES F13A1
33 dentin dysplasia with sclerotic bones 10.1 CD1A F13A1
34 rhabdomyosarcoma 2, alveolar 10.1 DES MB
35 extraosseous ewing's sarcoma 10.1 DES MB
36 pulmonary immaturity 10.0 F13A1 MB
37 fitz-hugh-curtis syndrome 10.0 ANTXR2 DES
38 palmoplantar keratosis 10.0 DES MB
39 neutrophil immunodeficiency syndrome 10.0 DES F13A1
40 adenosarcoma 9.9 DES MB
41 hemangioma 9.8
42 infantile myofibromatosis 9.8
43 sarcoma 9.8
44 gingivitis 9.8
45 myopericytoma 9.8
46 dermoid cyst 9.8
47 benign mesenchymoma 9.8
48 mesenchymoma 9.8
49 liposarcoma 9.8
50 leiomyomatosis 9.8

Graphical network of the top 20 diseases related to Myofibroma:



Diseases related to Myofibroma

Symptoms & Phenotypes for Myofibroma

UMLS symptoms related to Myofibroma:


pelvic pain

MGI Mouse Phenotypes related to Myofibroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ANTXR2 DES F13A1 MB RELA WNT7A
2 mortality/aging MP:0010768 9.1 MB RELA WNT7A ANTXR2 DES F13A1

Drugs & Therapeutics for Myofibroma

Drugs for Myofibroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 255)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2 Dienogest Approved Phase 4 65928-58-7
3
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
4
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
5
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
6
Dimenhydrinate Approved Phase 4 523-87-5 441281
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Calcium carbonate Approved Phase 4,Phase 3 471-34-1
9
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53714-56-0 3911 657181
10
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
11
Zinc Approved Phase 4 7440-66-6 32051 23994
12
Zinc oxide Approved Phase 4 1314-13-2
13
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
14
Ethanol Approved Phase 4 64-17-5 702
15
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Prilocaine Approved Phase 4 721-50-6 4906
21
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
22
Remifentanil Approved Phase 4 132875-61-7 60815
23
Dinoprostone Approved Phase 4 363-24-6 5280360
24
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
25
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 57-83-0 5994
26
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
27
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
29
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1 1197-18-8 5526
30
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
31
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
32
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
33
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
34
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
35
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
36
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
39
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
40
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
41
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
42
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
43
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
44
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
45
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
46 tannic acid Approved, Nutraceutical Phase 4
47 Anabolic Agents Phase 4
48 Androgens Phase 4
49 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
50 Contraceptive Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 306)
id Name Status NCT ID Phase
1 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
2 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4
3 MyoSure Hysteroscopic Tissue Removal System Registry Study Unknown status NCT01369758 Phase 4
4 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4
5 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
6 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4
7 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4
8 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
9 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
10 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
11 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
12 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4
13 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
14 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4
15 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
16 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
17 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4
18 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4
19 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4
20 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4
21 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Recruiting NCT02361905 Phase 4
22 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Recruiting NCT02361879 Phase 4
23 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4
24 Ulipristal Use in Chinese Population Recruiting NCT02825719 Phase 4
25 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Recruiting NCT02357563 Phase 4
26 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Recruiting NCT02288130 Phase 4
27 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Recruiting NCT02361892 Phase 4
28 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4
30 Uterine Leiomyoma Treatment With Radiofrequency Ablation Active, not recruiting NCT01840124 Phase 4
31 Pilot of Letrozole for Uterine Myomas Active, not recruiting NCT02470741 Phase 4
32 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Active, not recruiting NCT00995878 Phase 4
33 Laparoscopic Uterine Sparing Techniques Outcomes and Reinterventions Active, not recruiting NCT01750008 Phase 4
34 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
35 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Not yet recruiting NCT02601196 Phase 4
36 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Not yet recruiting NCT02440750 Phase 4
37 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Phase 4
38 Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids Terminated NCT01328067 Phase 4
39 Uterine Fibroid Pregnancy Registry Terminated NCT00232713 Phase 4
40 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4
41 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
42 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3
43 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
44 Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma Unknown status NCT01715597 Phase 3
45 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
46 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
47 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
48 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3
49 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3
50 Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids Completed NCT01141062 Phase 3

Search NIH Clinical Center for Myofibroma

Cochrane evidence based reviews: myofibroma

Genetic Tests for Myofibroma

Anatomical Context for Myofibroma

MalaCards organs/tissues related to Myofibroma:

39
Bone, Testes, Smooth Muscle, Tongue, Colon, Breast, Testis

Publications for Myofibroma

Articles related to Myofibroma:

(show top 50) (show all 134)
id Title Authors Year
1
Myofibroma in Infancy and Childhood. ( 28060105 )
2017
2
Recurrent SRF-RELA Fusions Define a Novel Subset of Cellular Myofibroma/Myopericytoma: A Potential Diagnostic Pitfall With Sarcomas With Myogenic Differentiation. ( 28248815 )
2017
3
Solitary Infantile Myofibroma of Left Ethmoid Sinus With Intracranial Extension. ( 26869266 )
2016
4
Tumour that challenged diagnosis: mandibular myofibroma. ( 27737873 )
2016
5
Solitary Myofibroma of the Bladder Trigone in a 3-Month-Old Patient: First Case Report. ( 27242942 )
2016
6
Six Cases of Myofibroma--The Adult Counterpart of Infantile Myofibromatosis: Case Report. ( 26718074 )
2016
7
Unusual Presentation of Infantile Myofibroma in the Deep Palm of a Child: A Case Report and Discussion of the Differential Diagnosis. ( 27955965 )
2016
8
Pediatric Myofibroma of the Palate with Ulceration and Bone Destruction. ( 27403363 )
2016
9
Surgical Management of Myofibroma of the Gengiva. ( 27526249 )
2016
10
Central myofibroma of the maxilla. ( 27041905 )
2016
11
Infantile myofibroma: a firm, round plaque in an infant. ( 27617527 )
2016
12
Multicentric myofibromatosis presenting as a large congenital eyelid myofibroma. ( 26917077 )
2016
13
Myofibroma arising from a digital artery. ( 27452742 )
2016
14
Large, exophytic mass on the scalp of a newborn. Solitary infantile myofibroma. ( 25801078 )
2015
15
Transcatheter management of mid-aortic syndrome secondary to myofibroma presenting in infancy with severe left ventricular dysfunction: a case report. ( 26448630 )
2015
16
Head and neck solitary infantile myofibroma: Clinicopathological and immunohistochemical features of a case series. ( 25744090 )
2015
17
Myofibroma-a rare entity with unique clinical presentation. ( 25838671 )
2015
18
Ruptured Infantile Myofibroma of the Head Presenting in a Neonate: Case Report and Review of the Literature. ( 26459706 )
2015
19
Myofibroma of the Left Supraspinous Muscle on 18F-FDG PET/CT. ( 26402126 )
2015
20
A rare case of a myofibroma presenting on the tongue. ( 26263954 )
2015
21
Myofibroma of the gingiva: a rare case report and literature review. ( 25918649 )
2015
22
Infantile myofibroma: a firm, round plaque in an infant. ( 26632798 )
2015
23
Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature. ( 26330794 )
2015
24
Pediatric solitary intraosseous infantile myofibroma of the mandible. ( 24709433 )
2014
25
Myofibroma of the tongue: a case suggesting autosomal dominant inheritance. ( 23850370 )
2014
26
Rapid growing myofibroma of the gingiva: report of a case and review of the literature. ( 23945519 )
2014
27
Myofibroma. ( 24738101 )
2014
28
An unusual timing for symptomatic chest pain in an adult chest wall myofibroma: a case report. ( 24947050 )
2014
29
Prenatal Diagnosis of Infantile Myofibroma with Postnatal Imaging Correlation. ( 25139493 )
2014
30
Mandibular swelling in a 5-year-old child--mandibular myofibroma. ( 25178888 )
2014
31
Solitary myofibroma of the oropharynx causing airway obstruction in an adult. ( 25255348 )
2014
32
Solitary intestinal myofibroma an unusual cause of neonatal intestinal obstruction. ( 25971831 )
2014
33
Solitary adult myofibroma. ( 24897142 )
2014
34
Solitary intraosseous myofibroma of the tibia in an adult patient: A case report. ( 26909302 )
2014
35
Solitary myofibroma of the mandible in an adult with magnetic resonance imaging and positron emission tomography findings: a case report. ( 24678877 )
2014
36
Solitary myofibroma of the adult mandible: a case report and review of literature. ( 25214864 )
2014
37
Myofibroma of the cervical spine presenting as brachialgia. ( 25303617 )
2014
38
Myofibroma in the palm presenting with median nerve compression symptoms. ( 25426387 )
2014
39
Congenital myofibroma mimicking an infantile hemangioma in an infant. ( 24891688 )
2014
40
Solitary myofibroma of the adult mandible: a case report. ( 23021917 )
2013
41
A case of congenital myofibroma of the orbit presenting at birth. ( 23387453 )
2013
42
Solitary myofibroma of the sigmoid colon: case report and review of the literature. ( 23742153 )
2013
43
Solitary myofibroma of the mandible: an immunohistochemical and ultrastructural study with a review of the literature. ( 24213519 )
2013
44
Congenital myofibroma masquerading as an ulcerated infantile hemangioma in a neonate. ( 22276856 )
2013
45
Submandibular myofibroma: a case report. ( 23404191 )
2013
46
Intraosseous myofibroma of mandible: A rarity of jaws: With clinical, radiological, histopathological and immunohistochemical features. ( 23798845 )
2013
47
A case of congenital solitary testicular myofibroma associated with an undescended testis. ( 23856846 )
2013
48
Upper airway distress due to an oropharyngeal infantile myofibroma. ( 21733702 )
2012
49
Myofibroma of the mandible: a case report. ( 23007936 )
2012
50
Infantile myofibroma eroding into the frontal bone: a case report and review of its histopathologic differential diagnosis. ( 22966474 )
2012

Variations for Myofibroma

Expression for Myofibroma

Search GEO for disease gene expression data for Myofibroma.

Pathways for Myofibroma

GO Terms for Myofibroma

Biological processes related to Myofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 8.62 MB RELA

Sources for Myofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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