Myopathy malady

NINDS: The myopathies are neuromuscular disorders in which the primary symptom is muscle weakness due to dysfunction of muscle fiber. Other symptoms of myopathy can include include muscle cramps, stiffness, and spasm. Myopathies can be inherited (such as the muscular dystrophies) or acquired (such as common muscle cramps). Myopathies are grouped as follows:: characterized by developmental delays in motor skills; skeletal and facial abnormalities are occasionally evident at birth: characterized by progressive weakness in voluntary muscles; sometimes evident at birth: caused by genetic abnormalities in mitochondria, cellular structures that control energy; include Kearns-Sayre syndrome, MELAS and MERRF: caused by mutations in genes controlling enzymes that metabolize glycogen and glucose (blood sugar); include Pompe's, Andersen's and Cori's diseases: caused by disorders in the metabolism of a fuel (myoglobin) necessary for muscle work; include McArdle, Tarui, and DiMauro diseases: an inflammatory myopathy of skin and muscle: characterized by bone growing in muscle tissue: characterized by episodes of weakness in the arms and legs: inflammatory myopathies of skeletal muscle: characterized by alternating episodes of twitching and stiffness; and³¹

MalaCards: Myopathy is related to neuronitis and neuropathy. An important gene associated with Myopathy is MYH7 (myosin, heavy chain 7, cardiac muscle, beta), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinsons disease. The compounds wortmannin and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology: A muscular disease in which the muscle fibers do not function resulting in muscular weakness.⁶

Wikipedia: In medicine, a myopathy is a muscular disease in which the muscle fibers do not function for any one of...⁴⁴ more...

Aliases & Descriptions:

myopathy 6 7 31 8 32 43

Diseases related to myopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1129)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	42.7	PIK3R1, PIK3C2A, PIK3C3, NCAM1, RELA, SGCA
2	neuropathy	41.5	PIK3C2A, NCAM1, SGCA, VPS13A, BTD, SELE
3	myositis	40.9	PIK3C2A, NCAM1, VIM, NARS, VCAM1, VCP
4	centronuclear myopathy	40.7	PIK3R4, PIK3C3, NCAM1, MYF6, BIN1, CHKB
5	thyroiditis	40.3	PIK3R1, PIK3C2A, NCAM1, RELA, SELE, SEPW1
6	muscular dystrophy	39.8	PIK3C2A, NCAM1, SGCA, SGCB, SEPN1, LMNA
7	inclusion body myopathy	39.6	NCAM1, RENBP, NAGK, VCP, MYOT, ATP7A
8	polymyositis	38.3	PIK3C2A, NCAM1, SELE, VCAM1, MYBPC1, UTRN
9	nemaline myopathy	38.2	MYOT, TPM1, TPM2, TPM3, TNNT1, ACTA1
10	dementia	38.1	PIK3C2A, NCAM1, CNBP, VCAM1, VCP, CLU
11	hypertrophic cardiomyopathy	37.7	PIK3C2A, COA5, SGCA, SGCB, VDAC1, LMNA
12	myopathy congenital	36.5	SEPN1, MYOG, CHKB, MTM1, ITGA7, DYSF
13	anemia	36.2	NCAM1, RELA, SGCB, SELE, VCAM1, LMNA
14	diabetes mellitus	36.0	PIK3R1, PIK3C2A, SGCB, BTD, SELE, VDAC1
15	myofibrillar myopathy	35.6	SEPN1, CRYAB, RPS27A, SYNC, DES
16	bethlem myopathy	35.5	LAMB1, DMD, COL6A3, COL6A1, COL6A2, COL6A5
17	miyoshi myopathy	35.3	SGCA, MYOF, CHKB, CAPN3, DYSF, DCTN1
18	vacuolar myopathy	35.1	VMA21, LAMP2, MPP2, GUSB, GNE, CAV3
19	frontotemporal dementia	34.5	CNBP, VCP, BAX, MPFD, CDKN3, APOE
20	immunodeficiency	34.5	BLZF1, CD28, CD79A, CD40LG, CD80, CD274
21	dermatomyositis	34.3	PIK3C2A, SELE, VCAM1, MYBPC1, UTRN, SDHB
22	lupus erythematosus	34.2	PIK3C2A, CNBP, SELE, SEPN1, VCAM1, BOK
23	cataract	33.9	SGCB, CNBP, VIM, LMNA, MYOT, BLZF1
24	retinitis	33.9	PIK3C2A, SGCB, CNBP, SELE, VIM, VCAM1
25	inclusion body myositis	33.8	VCAM1, CD80, MME, APP, MAPT, ICAM1
26	idiopathic myopathy	33.6	NARS, CHKB, IL1A, IL1R1, CCL2, CCL5
27	limb-girdle muscular dystrophy	33.4	SGCA, FKRP, CAPN3, DYSF, DMD, TCAP
28	systemic lupus erythematosus	33.4	CNBP, SELE, VCAM1, BLZF1, CLU, LAMB1
29	hypotonia	33.4	COA5, BTD, LMNA, SCO1, MVK, MT-CO1
30	mitochondrial encephalomyopathy	33.4	MT-ND5, MT-CO2, MT-ATP6, MSTN, HSPD1, COX5A
31	central core myopathy	33.4	SEPN1, MYOT, DES, RYR1, NEB, GAA
32	congenital fiber-type disproportion	33.2	SEPN1, CFTDX, INSR, TPM3, ACTA1, RYR1
33	ataxia	33.2	PIK3R1, CNTN1, BTD, SECISBP2, VIM, NARS
34	paget's disease of bone	33.1	VCP, FLNC, IL1B, IL1R1, IL6, IL8
35	fibrosis	33.1	RELA, BTD, SELE, VIM, VDAC1, VCAM1
36	myotonic dystrophy	32.8	PIK3C2A, SGCA, CNBP, VIM, LMNA, MYOG
37	malignant hyperthermia	32.7	PIK3C2A, SEPN1, SCN4A, CHKB, LAMA2, QDPR
38	lactic acidosis	32.7	PIK3C2A, GUSB, APP, MB, HSPG2, ETFDH
39	ophthalmoplegia	32.5	PIK3C2A, SEPN1, MT-RNR2, MTMR14, MT-RNR1, IBM3
40	obesity	32.3	PIK3R1, PIK3C2A, RELA, SELE, VDAC1, VCAM1
41	danon disease	32.3	VMA21, LAMP2, MPP2, DMD, GAA
42	pharyngitis	32.2	VIM, MYPN, MYOT, PABPN1, BCL2, SDHB
43	myotonic dystrophy type 2	32.0	CNBP, CLCN1, CHKB, MTMR1, INSR, DMPK
44	distal muscular dystrophy	32.0	RENBP, CHKB, LDB3, MATR3, GNE, DYSF
45	becker muscular dystrophy	31.9	PIK3C2A, NCAM1, SGCA, UTRN, LAMA2, FKTN
46	ullrich congenital muscular dystrophy	31.8	PIK3C2A, SGCA, SEPN1, VIM, LMNA, MYOT
47	dysferlinopathy	31.6	MYOF, GPT, CAPN3, DYSF, OTOF, TCAP
48	hepatitis c	31.6	CD28, CD40LG, IL4, FAS, CCL4, CCR5
49	sideroblastic anemia	31.4	YARS2, MT-CO1, ISCU, SUCLA2, COX5A, PUS1
50	pulmonary disease	31.4	SELE, VCAM1, MYOG, MYOD1, BCL2, SDHB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myopathy:

²²

MGI Mouse Phenotypes related to myopathy:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	INF	MYOG, MYF6, MYOD1, UTRN, PAX7, LDB3
2	liver/biliary system phenotype	MP:0005370	INF	PIK3C3, UTRN, CHKA, BAG3, , MTM1
3	cellular phenotype	MP:0005384	INF	PIK3R1, PIK3C3, NCAM1, RELA, CNBP, CNTN1
4	mortality/aging	MP:0010768	INF	PIK3C2A, PIK3C3, NCAM1, RELA, CNBP, CNTN1
5	integument phenotype	MP:0010771	INF	RELA, BTD, LMX1B, MYOG, BIN1, CLCN1
6	muscle phenotype	MP:0005369	INF	PIK3R1, PIK3C3, RELA, SGCA, SGCB, CNTN1
7	endocrine/exocrine gland phenotype	MP:0005379	INF	PAX7, LAMA2, SBF1, CD40LG, GUSB, GSN
8	cardiovascular system phenotype	MP:0005385	INF	PIK3R1, PIK3C3, RELA, SGCA, SGCB, SELE
9	behavior/neurological phenotype	MP:0005386	INF	PIK3C3, NCAM1, CNTN1, , BTD, SELE
10	other phenotype	MP:0005395	INF	CLU, LAMA2, LAMA5, CD40LG, MME,
11	no phenotypic analysis	MP:0003012	INF	PIK3R1, VCAM1, LMX1B, MYF6, MYOD1, MYOT
12	limbs/digits/tail phenotype	MP:0005371	11.1	RELA, LMNA, LMX1B, UTRN, CHKB, BAX
13	tumorigenesis	MP:0002006	10.8	PIK3R1, MYF6, BIN1, PAX7, BCL2, S100A4
14	nervous system phenotype	MP:0003631	INF	RELA, CNBP, CNTN1, , VDAC1, VCP
15	embryogenesis phenotype	MP:0005380	INF	PIK3C3, CNBP, VIM, MYOG, MYF6, PAX7
16	skeleton phenotype	MP:0005390	INF	RELA, CNBP, SEPN1, VCP, LMNA, LMX1B
17	immune system phenotype	MP:0005387	INF	PIK3C3, SGCA, SGCB, VIM, LMNA, BIN1
18	renal/urinary system phenotype	MP:0005367	INF	RENBP, BTD, LMNA, LMX1B, UTRN, CLU
19	normal phenotype	MP:0002873	INF	PIK3R1, PIK3C3, RELA, SELE, SEPN1, NAGK
20	adipose tissue phenotype	MP:0005375	INF	PIK3R1, PIK3C2A, LMNA, MYOG, MYF6, MYOD1
21	reproductive system phenotype	MP:0005389	INF	LMNA, MYOD1, UTRN, BIN1, CLCN1, MTMR2
22	vision/eye phenotype	MP:0005391	INF	NCAM1, RELA, CNBP, CNTN1, BTD, SELE
23	hematopoietic system phenotype	MP:0005397	INF	, BCL2, BAG3, LAIR1, LAMA2, XIAP
24	digestive/alimentary phenotype	MP:0005381	INF	LMNA, PAX7, BCL2, LDB3, LAMA5, MSTN
25	craniofacial phenotype	MP:0005382	INF	CNBP, LMX1B, PAX7, LAMA2, LAMA5, LAMP2
26	growth/size phenotype	MP:0005378	INF	PIK3R1, PIK3C2A, PIK3C3, RELA, SGCB, CNBP
27	hearing/vestibular/ear phenotype	MP:0005377	INF	LMNA, CLCN1, BCL2, , BAX,
28	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3R1, PIK3C2A, PIK3C3, RELA, RENBP, SGCA

Articles related to myopathy:

(show top 50)    (show all 1038)

id	Title	Authors	Year	Affiliating Genes
1	Cytokine gene polymorphisms are associated with marke rs of disease severity and prognosis in patients with idiopathic dilated cardio myopathy. (21282066)	Adamopoulos S.... Kremastinos D.T.	2011	TGFB1, IL6, IFNG
2	Identification of a deep intronic mutation in the COL 6A2 gene by a novel custom oligonucleotide CGH array designed to explore alleli c and genetic heterogeneity in collagen VI-related myopathies. (20302629)	Bovolenta M.... Gualandi F.	2010	COL6A2
3	Myosin storage myopathy: a rare subtype of protein a ggregate myopathies (20376763)	Kiphuth I.C.... SchrAPder R.	2010	MYH7
4	Novel missense mutation p.A310P in the GNE gene in au tosomal-recessive hereditary inclusion-body myopathy/distal myopathy with rimme d vacuoles in an Italian family. (20346669)	Stober A.... Krause S.	2010	GNE
5	Thin filament length dysregulation contributes to mus cle weakness in nemaline myopathy patients with nebulin deficiency. (19346529)	Ottenheijm C.A.... Granzier H.	2009	NEB
6	A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation. (19122038)	Bitoun M.... Romero N.B.	2009	DNM2
7	The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. (18821667)	Chinoy H.... Cooper R.G.	2008	PTPN22
8	Atypical Parkinsonism in distal myopathy with rimmed vacuoles. (18383535)	Ishihara T.... Nishizawa M.	2008	GNE
9	Perspectives on distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy: contributions from an animal model. Lack of sialic acid, a central determinant in sugar chains, causes myopathy? (18646567)	Malicdan M.C.... Nishino I.	2007	GNE
10	Dysferlin expression in limb-girdle muscular dystrophy and Miyoshi myopathy: analysis of 45 cases (17785089)	Ren S.C.... Li D.N.	2007	DYSF
11	MYH7 gene mutation in myosin storage myopathy and scapulo-peroneal myopathy. (17336526)	Pegoraro E.... Angelini C.	2007	MYH7
12	C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. (17444505)	Carmignac V.... Ferreiro A.	2007	TTN
13	A Gne knockout mouse expressing human V572L mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy. (17164266)	Malicdan M.C.... Nishino I.	2007	GNE
14	A Gne knockout mouse expressing human GNE D176V mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy. (17704511)	Malicdan M.C.... Nishino I.	2007	GNE
15	Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: clinical and pathological variability within a kindred. (16427282)	Hutchinson D.O.... North K.N.	2006	ACTA1
16	Clinical and genetic analysis of Korean patients with Miyoshi myopathy: identification of three novel mutations in the DYSF gene. (16891820)	Cho H.J.... Kim J.W.	2006	DYSF
17	Apoptosis in mitochondrial myopathies is linked to mi tochondrial proliferation. (16537564)	AurAc K.... LombA"s A.	2006	COX5A
18	Serum creatine kinase response to exercise during dexamethasone-induced insulin resistance in Quarter Horses with polysaccharide storage myopathy. (16273902)	Firshman A.M.... Seaquist E.R.	2005	INS, CHKB
19	Distal myopathy with rimmed vacuoles and hereditary inclusion body myopathy. (15676110)	Nonaka I.... Nishino I.	2005	GNE
20	Low myopathy rates associated with statins as monotherapy or combination therapy with interacting drugs in a group model health maintenance organization. (15843281)	Shanahan R.L.... Merenich J.A.	2005	CYP3A4
21	Expression of the beta chemokines CCL3, CCL4, CCL5 and their receptors in idiopathic inflammatory myopathies. (15634233)	Civatte M.... Figarella-Branger D.	2005	CCR5, CCL5, CCR1
22	SINE exonic insertion in the PTPLA gene leads to multiple splicing defects and segregates with the autosomal recessive centronuclear myopathy in dogs. (15829503)	Pele M.... Panthier J.J.	2005	MTM1
23	Single nucleotide polymorphisms in the dystroglycan gene do not correlate with disease severity in hereditary inclusion body myopathy. (16112887)	Gottlieb E.... Huizing M.	2005	DAG1
24	A novel mutation in the mitochondrial tRNA(Phe) gene associated with mitochondrial myopathy. (14659412)	Moslemi A.R.... Oldfors A.	2004	MT-TF
25	Functional characterisation of a mutant actin (Met132Val) from a patient with nemaline myopathy. (14733965)	Marston S.... Sewry C.	2004	ACTA1
26	Progressive myopathy with circulating autoantibody against giantin in the Golgi apparatus. (15159505)	Sahashi K.... Kondo H.	2004	GOLGB1
27	The second kindred with autosomal dominant distal myopathy linked to chromosome 14q: genetic and clinical analysis. (12975303)	Hedera P.... Fink J.K.	2003	PABPN1
28	Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease. (12839838)	Sotgia F.... Lisanti M.P.	2003	CAV3
29	A recurrent R718W mutation in COMP results in multiple epiphyseal dysplasia with mild myopathy: clinical and pathogenetic overlap with collagen IX mutations. (14684695)	Jakkula E.... Superti-Furga A.	2003	COMP
30	Progressive skeletal myopathy, a phenotypic variant of desmin myopathy associated with desmin mutations. (12609507)	Dalakas M.C.... Goldfarb L.G.	2003	DES
31	Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis. (12124873)	Shamim E.A.... Miller F.W.	2002	HLA-DQB1, HLA-DRB1
32	Novel COL6A1 splicing mutation in a family affected by mild Bethlem myopathy. (11932968)	Vanegas O.C.... Pepe G.	2002	COL6A1
33	Distal myopathy with rimmed vacuoles is allelic to hereditary inclusion body myopathy. (12473753)	Nishino I.... Nonaka I.	2002	GNE
34	Heterozygous myogenic factor 6 mutation associated with myopathy and severe course of Becker muscular dystrophy. (11053684)	Kerst B.... Huebner C.	2000	MYF6
35	Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene. (10717012)	Dalakas M.C.... Goldfarb L.G.	2000	DES
36	Proximal myotonic myopathy: clinical and molecular investigation of a Norwegian family with PROMM. (10665666)	Sun C.... Tranebjaerg L.	1999	DMPK, CLCN1
37	Myopathy, myasthenic syndrome, and epidermolysis bullosa simplex due to plectin deficiency. (10446808)	Banwell B.L.... Engel A.G.	1999	PLEC
38	Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy. (10508519)	Nowak K.J.... North K.N.	1999	ACTA1
39	Caveolin-3 and sarcoglycans in the vacuolar myopathies and centronuclear myopathy. (10417791)	Inose M.... Osame M.	1999	DMD, CAV3, SPTB
40	Myopathy as the persistently isolated symptomatology of primary autoimmune hypothyroidism. (9848719)	Rodolico C.... Vita G.	1998	DES
41	Congenital myopathy with mosaic fibers and interlacing sarcomeres: a new structural myopathy. (9845295)	Marbini A.... Margarito F.	1998	DNAH8
42	Study of myopathies by histological and histochemical methods with special reference to staining for desmin expression. (9354004)	Bhattacheryya A.... Sinha S.	1997	DES
43	Myopathy caused by inhibitors of hydroxymethylglutaryl-coenzyme A reductase (9244616)	Martinez-GarcA-a F.A.... FernA!ndez-Barreiro A.	1997	HMGCR
44	Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures. (8782832)	Joebsis G.J.... Bohlhuis P.A.	1996	COL6A1, COL6A2, COL6A3
45	Familial desmin myopathies and cytoplasmic body myopathies. (8922062)	Baeta A.M.... Pellissier J.F.	1996	DES
46	Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. (7849699)	Poulton J.... Hansen F.J.	1994	VDAC1, TFAM
47	Quadriceps myopathy as dystrophin-associated myopathy (8211039)	von Mitzlaff H.C.... Burgunder J.M.	1993	DMD
48	Expression of cell surface and cytoskeleton developmentally regulated proteins in adult centronuclear myopathies. (1517767)	Figarella-Branger D.... Pellissier J.F.	1992	DES, NCAM1
49	Two cases of X-linked ichthyosis associated with myopathies (2253421)	Ishikawa Y.... Minami R.	1990	STS
50	Dystrophin expression and genotypic analysis of two cases of benign X linked myopathy (McLeod's syndrome). (2193159)	Carter N.D.... Jeffery S.	1990	DMD

Genes related to myopathy according to GeneCards:

(show top 50)    (show all 448)

id	Symbol	Description	Score	GeneCards Section Context
1	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.1	Summaries, Publications, Aliases & Descriptions
2	MTM1	myotubularin 1	11.1	Aliases & Descriptions, Publications, Orthologs, Summaries
3	MATR3	matrin 3	11.1	Aliases & Descriptions, Publications, Summaries
4	ACTA1	actin, alpha 1, skeletal muscle	11.1	Summaries, Publications
5	DES	desmin	11.1	Publications, Summaries
6	GNE	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	11.1	Summaries, Publications
7	COL6A3	collagen, type VI, alpha 3	11.1	Summaries, Publications
8	DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	11.1	Publications, Orthologs, Summaries
9	MYOT	myotilin	11.1	Summaries, Publications
10	NEB	nebulin	11.1	Publications, Summaries
11	RYR1	ryanodine receptor 1 (skeletal)	11.1	Publications, Summaries
12	TNNT1	troponin T type 1 (skeletal, slow)	11.1	Publications, Summaries
13	TPM3	tropomyosin 3	11.0	Publications, Summaries
14	VMA21	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)	11.0	Aliases & Descriptions, Publications
15	CFL2	cofilin 2 (muscle)	11.0	Publications, Summaries
16	MYH2	myosin, heavy chain 2, skeletal muscle, adult	11.0	Summaries
17	PUS1	pseudouridylate synthase 1	11.0	Publications, Summaries
18	CRYAB	crystallin, alpha B	11.0	Publications, Functions, Summaries
19	AMPD1	adenosine monophosphate deaminase 1	11.0	Summaries, Publications
20	COL6A2	collagen, type VI, alpha 2	11.0	Summaries, Publications
21	MTMR14	myotubularin related protein 14	11.0	Publications, Summaries
22	LDB3	LIM domain binding 3	11.0	Summaries, Publications
23	TPM2	tropomyosin 2 (beta)	11.0	Summaries, Publications
24	COL6A1	collagen, type VI, alpha 1	11.0	Summaries, Publications
25	MYF6	myogenic factor 6 (herculin)	11.0	Publications, Summaries
26	ITGA7	integrin, alpha 7	11.0	Publications, Summaries
27	CFTDX	Myopathy, congenital, with fiber-type disproportion, X-linked	11.0	Aliases & Descriptions
28	IBM3	inclusion body myopathy 3, autosomal dominant	11.0	Aliases & Descriptions, Publications
29	MEGF10	multiple EGF-like-domains 10	11.0	Summaries, Publications
30	ISCU	iron-sulfur cluster scaffold homolog (E. coli)	11.0	Publications, Summaries
31	YARS2	tyrosyl-tRNA synthetase 2, mitochondrial	11.0	Summaries, Publications
32	MPD3	Myopathy, distal 3	11.0	Aliases & Descriptions
33	MHB	myopathy, hyaline body, autosomal recessive	11.0	Publications, Aliases & Descriptions
34	MPFD	myopathy with fiber type disproportion	11.0	Aliases & Descriptions, Publications
35	PNPLA2	patatin-like phospholipase domain containing 2	11.0	Summaries, Publications
36	TNNI2	troponin I type 2 (skeletal, fast)	11.0	Publications, Summaries
37	ALDOA	aldolase A, fructose-bisphosphate	11.0	Summaries, Publications
38	EMD	emerin	11.0	Summaries
39	WDM	Welander distal myopathy	11.0	Publications, Aliases & Descriptions
40	COA5	cytochrome C oxidase assembly factor 5	11.0	Summaries
41	LIMM	lethal infantile mitochondrial myopathy	11.0	Aliases & Descriptions
42	NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	11.0	Publications, Summaries
43	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Summaries, Publications
44	CTSL1	cathepsin L1	11.0	Summaries
45	DMD	dystrophin	11.0	Publications
46	TTN	titin	11.0	Publications
47	CHKB	choline kinase beta	11.0	Publications
48	FHL1	four and a half LIM domains 1	11.0	Publications
49	GAA	glucosidase, alpha; acid	11.0	Publications
50	RPS27A	ribosomal protein S27a	11.0	Publications

Pathways related to myopathy according to GeneDecks:

(show top 50)    (show all 196)

id	Pathway	Score	Top Affiliating Genes
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.38	INF	MT-ND5, , , MT-CO1, MT-CO2,
2	Parkinsons disease20	INF	VDAC1, SDHB, MT-ND5, , , MT-CO1
3	Transendothelial Migration of Leukocytes36	12.7	PIK3R4, PIK3R1, VCAM1, LAMA2, LAMA5, LAMB1
4	Striated Muscle Contraction38	12.7	MYBPC1, TPM1, TPM2, TPM3, TNNI2, TNNI3
5	Viral myocarditis20	12.6	SGCA, SGCB, LAMA2, CD28, CD86, CD40LG
6	Dilated cardiomyopathy20	12.6	SGCA, SGCB, LMNA, LAMA2, ITGA4, ITGA7
7	Hypertrophic cardiomyopathy (HCM)20	12.4	SGCA, SGCB, LMNA, LAMA2, ITGA4, ITGA7
8	Allograft rejection20	12.3	CD28, CD86, CD40LG, CD80, CD40, GZMB
9	Rheumatoid arthritis20	12.2	ATP6V0E1, CD28, CD86, CD80, ITGAL, ITGB2
10	Akt Signaling36	12.2	PIK3R4, PIK3R1, CD28, CD80, ITGA7, ITGAL
11	Type I diabetes mellitus20	12.2	CD28, CD86, CD80, GZMB, INS, IL1A
12	Cell adhesion molecules (CAMs)20	12.2	NCAM1, CNTN1, CD28, CD86, CD80, CD40
13	Antioxidant Action of Vitamin-C36	12.1	BCL2, BAX, CD28, CD80, FLNC, IL13
14	Leishmaniasis20	12.1	RELA, ITGA4, ITGB2, FCGR3A, IL1A, IL1B
15	ERK Signaling36	12.1	PIK3R4, PIK3R1, LAMA2, LAMA5, LAMB1, CD80
16	Tec Kinases Signaling36	12.0	PIK3R4, PIK3R1, BCL2, BAX, CD28, CD80
17	Autoimmune thyroid disease20	12.0	CD28, CD86, CD40LG, CD80, CD40, GZMB
18	Graft-versus-host disease20	11.9	CD28, CD86, CD80, IL1A, HLA-A, HLA-B
19	Influenza A20	11.8	PIK3R1, RELA, VDAC1, PABPN1, IL1A, IL1B
20	ILK Signaling36	11.8	PIK3R4, PIK3R1, VIM, LAMA2, LAMA5, LAMB1
21	Rho Family GTPases36	11.6	PIK3R4, PIK3R1, VIM, BCL2, BAX, LAMA2
22	PGC1Alpha Pathway36	11.5	BCL2, BAX, CD80, INSR, IL13, IL1A
23	STAT3 Pathway36	11.5	BCL2, BAX, CD28, CD80, IL13, IL1A
24	p38 Signaling36	11.4	BCL2, BAX, CD28, CD80, INSR, IL13
25	Toxoplasmosis20	11.4	PIK3R1, RELA, BCL2, LAMA2, LAMA5, LAMB1
26	Intestinal immune network for IgA production20	11.4	CD28, CD86, CD40LG, CD80, CD40, ITGA4
27	Cytokine-cytokine receptor interaction20	11.2	CD40LG, CD40, IL13, IL17A, IL1A, IL1B
28	MAPK Signaling36	11.1	PIK3R4, PIK3R1, BCL2, LAMA2, LAMA5, LAMB1
29	Endothelin-1 Signaling Pathway36	11.1	PIK3R4, PIK3R1, CD80, INSR, IL13, IL1A
30	MIF Mediated Glucocorticoid Regulation36	11.0	BCL2, BAX, CD80, MIF, IL13, IL1A
31	PTEN Pathway36	11.0	PIK3R4, PIK3R1, LAMA2, LAMA5, LAMB1, ITGA4
32	MIF Regulation of Innate Immune Cells36	11.0	BCL2, BAX, CD80, MIF, IL13, IL1A
33	Tuberculosis20	11.0	PIK3C3, RELA, BCL2, BAX, LAMP2, ITGB2
34	Apoptosis20	10.9	PIK3R1, RELA, BCL2, BAX, XIAP, IL1A
35	JAK-STAT Pathway36	10.9	PIK3R4, PIK3R1, BAX, CD80, INSR, IL13
36	Molecular Mechanisms of Cancer36	10.9	PIK3R4, PIK3R1, BCL2, BAX, LAMA2, CD80
37	PEDF Induced Signaling36	10.9	RELA, BCL2, BAX, CD80, IL13, IL1A
38	Toll-like receptor signaling pathway20	10.9	PIK3R1, RELA, CD86, CD80, CD40, IL1B
39	Natural killer cell mediated cytotoxicity20	10.9	PIK3R1, ITGAL, ITGB2, GZMB, FCGR3A, FAS
40	Focal adhesion20	10.8	PIK3R1, BCL2, LAMA2, LAMA5, LAMB1, XIAP
41	Malaria20	10.8	SELE, VCAM1, CD40LG, CD40, ITGAL, ITGB2
42	PAK Pathway36	10.8	PIK3R4, PIK3R1, BCL2, BAX, CFL2, CD80
43	Regulation of eIF4 and p70S6K36	10.6	PIK3R4, PIK3R1, BAX, CD80, ITGA4, ITGA7
44	MAPK Family Pathway36	10.4	PIK3R4, PIK3R1, BCL2, BAX, CD80, IL13
45	TGF-Beta Pathway36	10.4	PIK3R4, PIK3R1, BCL2, BAX, CD80, IL13
46	IL-6 Pathway36	10.3	PIK3R4, PIK3R1, BAX, CD80, IL4, IL8
47	Oxidative phosphorylation20	INF	SDHB, MT-ND5, , , MT-CO1, MT-CO2
48	Metabolic pathways20	INF	PIK3C2A, PIK3C3, BTD, SDHB, CKMT2, CHKA
49	Huntingtons disease20	INF	SDHB, BAX, MT-CO1, MT-CO2, , MT-CO3
50	Alzheimers disease20	INF	SDHB, MT-CO1, MT-CO2, , MT-CO3, MT-CYB

Compounds related to myopathy according to GeneDecks:

(show top 50)    (show all 449)

id	Compound	Score	Top Affiliating Genes
1	wortmannin32 42	INF	PIK3R4, PIK3R1, PIK3C2A, PIK3C3, SGCB, VIM
2	cholesterol32 9 18 9	INF	PIK3R1, PIK3C2A, CNBP, SELE, VCAM1, LMNA
3	estrogen32	INF	PIK3R1, MYOG, MYOD1, BIN1, CLU, CHKA
4	vegf32	INF	PIK3R1, PIK3C2A, NCAM1, SGCB, SELE, VCAM1
5	threonine32	INF	MYOD1, SCN4A, MT-ND5, , MT-CYB, QDPR
6	serine32	INF	PIK3R1, NCAM1, RELA, RENBP, SGCB, BTD
7	glucose 6-phosphate32 18	INF	VDAC1, CLU, SDHB, CHKA, CHKB, GYS1
8	ethanol32 34 9 18 9	16.8	NCAM1, CLU, SDHB, CHKA, ITGAL, ITGB2
9	sodium32 18	13.4	PIK3C2A, NCAM1, SGCB, BLZF1, CLCN1, SCN4A
10	aspartate32	12.1	PIK3R1, PIK3C2A, VIM, SDHB, CHKB, MT-CYB
11	butyrate32	12.0	VIM, MYOG, MYOD1, BLZF1, CLU, BCL2
12	pge232	12.0	SGCB, SELE, VCAM1, MT-CO2, CD86, MME
13	endotoxin32	12.0	CHKB, CD86, CD40, ITGAL, ITGB2, MIF
14	fmlp32	11.8	VIM, VCAM1, MT-CYB, ITGA4, ITGAL, ITGB2
15	sodium nitroprusside32	11.7	PIK3C2A, SGCB, CD40, MME, IL13, APP
16	ionomycin32	11.7	CD274, CD40, GZMA, GSN, ANXA1, CCL4
17	peroxynitrite32	11.4	SGCB, CKMT2, CHKB, MB, CCL3, CAT
18	lactacystin32	11.3	SELE, MYOD1, BCL2, CDKN3, AR, INSR
19	fenofibrate32 9 9	13.2	PIK3C2A, SELE, VIM, VCAM1, CD40LG, CD40
20	isoproterenol32 9 9	13.1	PIK3R1, VIM, MYBPC1, ITGAL, AR, INSR
21	il 1032	11.1	CD40, IL13, IL1A, IL1B, IL1R1, IL1RAPL2
22	hyaluronic acid32 18	12.0	VIM, MUC16, CFH, ITGAL, ITGB2, GZMB
23	sp 60012532 42	11.9	VCAM1, CD40, IL13, IL17A, CASP3
24	cyclophosphamide32 34 9 9	13.9	ITGA4, ITGAL, ITGB2, MBL2, DCK, NPPB
25	etoposide32 42 9 9	13.7	PIK3R1, SELE, CLU, BCL2, BAX, XIAP
26	c2ceramide32	10.5	MYOG, BAX, IL1B, HSPB1, CASP3, GH1
27	rosiglitazone32 9 18 9	13.5	SELE, VCAM1, LMNA, INS, INSR, IL1R1
28	pd 98,05932	10.4	PIK3R1, VCAM1, MYOG, BCL2, BAX, XIAP
29	4-hydroxynonenal32 18	11.1	CHKA, BAX, MME, GUSB, APOE, APP
30	formaldehyde32 18	INF	SELE, VIM, BLZF1, CD79A, CD40LG, CDKN3
31	ascorbic acid32 18	INF	SGCB, MYOG, SDHB, CHKA, CHKB, MT-CYB
32	progesterone32 42 9 18 9	INF	PIK3R1, NCAM1, BOK, CLU, BCL2, CHKA
33	proline32	INF	PIK3R1, VIM, CLU, , ,
34	ribonucleic acid32	INF	MYOG, BLZF1, CLU, , MT-CO1, MSTN
35	superoxide32 18	INF	PIK3R1, PIK3C2A, SGCB, VCAM1, VCP, BLZF1
36	h2o232	INF	PIK3R1, SGCB, VDAC1, BLZF1, CLU, SDHB
37	thymidine32 18	INF	PIK3R1, VDAC1, BOK, CLU, CHKA, CHKB
38	prostacyclin32	INF	PIK3C2A, SELE, VCAM1, MME, INSR, IL1A
39	dopamine32 9 18 9	INF	NCAM1, SELE, LMX1B, CLU, SDHB, CHKB
40	polysaccharide32	INF	NCAM1, SELE, VDAC1, VCAM1, VCP, CLU
41	methionine32	INF	VIM, VDAC1, SCN4A, MT-ND5, ,
42	indomethacin32 9 9	INF	VIM, CD79A, CD40LG, CDKN3, CD40, ITGB2
43	carnitine32	INF	CHKA, CHKB, CD79A, INS, MB, AMPD1
44	ly29400232	INF	PIK3R1, PIK3C2A, SELE, MYOG, CDKN3, ITGB2
45	fatty acid32	INF	PIK3C2A, BTD, MYOG, MYOD1, BLZF1, CLU
46	genistein32 9 18 9	INF	PIK3R1, SGCB, SELE, VIM, VCAM1, BLZF1
47	iron32 18	INF	PIK3C2A, SGCB, VIM, VDAC1, BLZF1, SDHB
48	retinoic acid32 42 18	INF	NCAM1, VIM, VCAM1, BOK, LMNA, MYOG
49	valine32	INF	VIM, SCN4A, MT-ND5, , AR, INSR
50	lipid32	INF	PIK3R1, PIK3C2A, PIK3C3, NCAM1, SELE, VIM

Cellular components related to myopathy according to GeneDecks:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:005743	INF	TAZ, ACADVL, NDUFV1, , NDUFS4,
2	cytoplasm	GO:005737	INF	NOS1, PLEK, PLEC, CRYAB, SNCA, SNTB2
3	plasma membrane	GO:005886	16.0	DAG1, DMPK, PTPRC, PTP4A2, DOK7, DTNA
4	cell surface	GO:009986	12.6	NGFR, CRYAB, SPTB, CYP3A4, DMD, TNFRSF4
5	external side of plasma membrane	GO:009897	12.6	CXCR4, NCAM1, VCAM1, LILRB1, CD28, CD79A
6	sarcolemma	GO:042383	12.4	DAG1, SNTA1, SNTB1, PLEC, NOS1, COL6A3
7	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	11.4	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
8	I band	GO:031674	11.4	MYL3, CACNA1S, RYR1, TTN, ACTC1, CASQ1
9	ER to Golgi transport vesicle membrane	GO:012507	11.4	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
10	dystrophin-associated glycoprotein complex	GO:016010	11.1	SNTB2, SNTB1, DAG1, DMD, CAV3, FKRP
11	troponin complex	GO:005861	11.1	TNNT3, TNNT2, TNNT1, TNNI3, TNNI2
12	muscle myosin complex	GO:005859	11.1	MYL4, MYL3, MYH7, MYH6, MYH2, MYL6B
13	MHC class II protein complex	GO:042613	11.0	HLA-DMA, HLA-DMB, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1
14	extracellular matrix	GO:031012	10.9	COL6A2, COL6A5, COL6A6, THBS1, TGFB2, DCN
15	mitochondrial nucleoid	GO:042645	10.8	HADHB, HADHA, POLG2, POLG, TFAM, ACADVL
16	myofibril	GO:030016	10.8	MYL2, MYH6, MYH3, MYH2, CAPN3, MYOD1
17	platelet alpha granule lumen	GO:031093	10.3	HGF, TGFB2, TGFB1, THBS1, ALDOA, ALB
18	axon	GO:030424	10.1	SNCA, TGFB1, TGFB2, STAT1, NEK3, GAP43
19	mitochondrial membrane	GO:031966	INF	, ACADL, , PRKCA, OGDH,
20	sarcoplasmic reticulum	GO:016529	INF	CACNA1S, RYR1, , AGL, NOS1, PYGM
21	mitochondrial matrix	GO:005759	INF	ACADL, ACADVL, TK2, TFAM, DGUOK, OGDH
22	Z disc	GO:030018	INF	MYPN, DNAJB6, TCAP, SYNC, , SYNPO2
23	extracellular space	GO:005615	INF	LAMA5, IL1A, IL1B, IL1RN, IL4, IL6
24	mitochondrion	GO:005739	INF	COX10, ACADVL, GFER, TGM2, TFAM, DNM3
25	extracellular region	GO:005576	INF	CTSS, CTSL1, SNCA, PLEK, NOTCH3, COL4A1
26	cytosol	GO:005829	INF	AP1G1, AMPD1, AMPD3, ALDH9A1, ALDOA, GNE
27	sarcomere	GO:030017	INF	MYL3, MYL2, MYH7, MYH6, MYH2,
28	actin cytoskeleton	GO:015629	INF	SPTB, SNCA, PDLIM3, ACTA1, SYNPO2,
29	protein complex	GO:043234	INF	SNTB2, COL6A1, COL6A2, ORAI1, PRKCZ, PRKCA

Biological processes related to myopathy according to GeneDecks:

(show top 50)    (show all 67)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	INF	ATP5E, QDPR, MTM1, MTMR6, MTMR14, MTMR4
2	glucose metabolic process	GO:006006	INF	GYS1, MDH2, ENO3, TPI1, GAA, TNF
3	mitochondrial respiratory chain complex I assembly	GO:032981	INF	TAZ, , NDUFAF6, , NDUFAF5,
4	respiratory electron transport chain	GO:022904	INF	, COX5A, , NDUFV1, ETFDH, ETFB
5	muscle contraction	GO:006936	13.1	MYH6, MYH7, MYH2, CACNA1S, SNTB1, CRYAB
6	immune response	GO:006955	12.9	HLA-DQA1, HLA-DMB, HLA-DMA, HLA-C, HLA-B, HLA-DQB1
7	muscle filament sliding	GO:030049	12.9	TPM2, TPM1, MYL6B, MYBPC1, VIM, TPM3
8	cytokine-mediated signaling pathway	GO:019221	12.3	RPS27A, CCL2, STAT1, IL1A, HLA-G, HLA-DRB1
9	cell adhesion	GO:007155	12.3	TNXB, COL6A3, COMP, COL6A1, COL6A5, COL6A6
10	interferon-gamma-mediated signaling pathway	GO:060333	12.1	IFNG, IFI30, VCAM1, NCAM1, ICAM1, HLA-A
11	phospholipid metabolic process	GO:006644	12.0	PIK3R1, GPD1, PIK3C2A, PIK3C3, CHKA, MTMR2
12	regulation of immune response	GO:050776	11.9	IGKC, HLA-B, HLA-G, HLA-A, ICAM1, IL4
13	anti-apoptosis	GO:006916	11.7	TNFRSF10D, SNCA, CRYAB, RPS27A, COMP, NGF
14	innate immune response	GO:045087	11.7	IGKC, IFNA2, IGHG2, IGHG1, RPS27A, BCL2
15	striated muscle contraction	GO:006941	11.6	TTN, CACNA1S, RYR3, PGAM2, NOS1, MYH6
16	T cell receptor signaling pathway	GO:050852	11.6	NFKBIA, IKBKG, HLA-DPB1, HLA-DQA1, PTPRC, NFKB1
17	ventricular cardiac muscle tissue morphogenesis	GO:055010	11.5	MYH6, TPM1, TNNI3, TNNT2, GAA, MYH7
18	T cell costimulation	GO:031295	11.5	CD86, HLA-DQA1, CD80, CD274, HLA-DQB1, HLA-DPB1
19	cellular calcium ion homeostasis	GO:006874	11.4	RYR3, PRKCA, TGFB1, DMPK, CCL2, CCR1
20	phosphatidylinositol biosynthetic process	GO:006661	11.3	MTMR14, MTMR3, MTMR6, MTMR4, MTMR1, MTMR2
21	virus-host interaction	GO:019048	11.3	PABPN1, CD80, CD86, BAX, BIN1, VDAC1
22	skeletal muscle tissue development	GO:007519	11.3	MYOG, TGFB2, MYL3, TAZ, DCN, MYF6
23	leukocyte cell-cell adhesion	GO:007159	11.3	CCL5, PTPRC, VCAM1, ICAM1, CD40LG, ITGA4
24	positive regulation of T cell proliferation	GO:042102	11.2	CCL5, IFNG, CCL19, PTPRC, CD28, VCAM1
25	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.2	TNF, RPS27A, NFKB1, PRKCZ, PRKCH, TGFB1
26	positive regulation of apoptotic process	GO:043065	11.2	ANXA1, GZMA, IL1B, APC, FAS, SOD1
27	cardiac muscle contraction	GO:060048	11.2	MYL4, TNNI3, ACTC1, TCAP, TAZ, GAA
28	aging	GO:007568	11.2	DCN, FAS, VCAM1, GSN, IL1B, ENO3
29	neutrophil chemotaxis	GO:030593	11.1	CCL3, ITGB2, IL1B, CKLF, IFNG, TGFB2
30	dendritic cell chemotaxis	GO:002407	11.1	CCR5, CCL21, CCR1, CXCR4, CCL5, CCL19
31	muscle cell homeostasis	GO:046716	11.0	GAA, ALDOA, SOD1, APC, PFKM, CAPN3
32	sarcomere organization	GO:045214	11.0	TCAP, MYPN, XIRP1, CAPN3, TPM1, TTN
33	defense response to virus	GO:051607	10.9	LILRB1, CXCL10, BCL2, CD86, CD40, IL6
34	lipopolysaccharide-mediated signaling pathway	GO:031663	10.8	CCL2, CCL3, NFKBIA, STAT1, TNF, TGFB1
35	cell surface receptor signaling pathway	GO:007166	10.8	CXCL10, CD28, NPPB, IFNA2, IFNG, HRAS
36	cell-cell signaling	GO:007267	10.8	IL13, IL17A, CCL4, CCR5, CCR1, CD86
37	platelet degranulation	GO:002576	10.5	TGFB2, TTN, THBS1, TGFB1, SOD1, HGF
38	B cell proliferation	GO:042100	10.5	HSPD1, BCL2, CD79A, PTPRC, CD40LG, CD40
39	positive regulation of smooth muscle cell proliferation	GO:048661	10.3	STAT1, TGM2, NOTCH3, IL13, IL6, CCL5
40	platelet activation	GO:030168	10.2	CD40LG, CLU, CD40, LAMP2, IL6, PRKCA
41	glycolysis	GO:006096	INF	ENO3, OGDH, ALDOA, DLAT, PFKM,
42	muscle organ development	GO:007517	INF	DMD, MYL4, MYH3, GAA, EMD, NEB
43	negative regulation of apoptotic process	GO:043066	INF	TNF, CAPN3, HSPD1, IL6, IL4, IL1RN
44	apoptotic process	GO:006915	INF	ACTC1, COMP, NGF, NGFR, NFKB1, NFKBIA
45	response to glucocorticoid stimulus	GO:051384	INF	IL1B, IL1RN, INSR, TNF, IL6, FAS
46	response to organic cyclic compound	GO:014070	INF	IL1RN, PRKCA, STS, , CYP17A1, ICAM1
47	response to drug	GO:042493	INF	CASP1, IL4, BCL2, IFNG, ICAM1, TNF
48	response to hypoxia	GO:001666	INF	TNF, VCAM1, CRYAB, CCL2, RYR1, NPPB
49	inflammatory response	GO:006954	INF	CCR5, IL1A, IL1B, IL6, AOC3, ANXA1
50	blood coagulation	GO:007596	INF	PLEK, HRAS, ALDOA, ALB, PRKCA, IFNA2

Molecular functions related to myopathy according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:042802	INF	TNF, PTS, SNCA, NFKBIA, PFKL, PFKM
2	actin binding	GO:003779	INF	MYH7, MYH6, MYH3, MYH2, EMD, NEB
3	structural constituent of muscle	GO:008307	12.3	MYL4, MYOT, MYL6B, MYBPC1, ASPH, CAPN3
4	protein tyrosine phosphatase activity	GO:004725	11.8	CDKN3, DUSP13, PTPN22, PTPLA, PTPMT1, PTPRC
5	receptor binding	GO:005102	11.4	HLA-B, HLA-G, TRDN, TNFSF13B, CRAT, TGFB2
6	cytokine activity	GO:005125	10.9	CCL4, IFNA2, IFNG, HMGB1, TNF, TNFSF13B
7	chemokine activity	GO:008009	10.5	CXCL10, CCL5, CCL19, CCL21, CCL3, CCL2
8	protease binding	GO:002020	10.3	RYR1, POLG, TTN, C10orf2, TNF, IL1R1
9	calcium ion binding	GO:005509	INF	THBD, TTN, ABP1, COMP, NOTCH3, SNCA
10	protein binding	GO:005515	INF	EMD, , DES, SYNPO2, SYNM,
11	protein homodimerization activity	GO:042803	INF	TGFB1, ABP1, NFKB1, PLEK, CRYAB, PTS
12	enzyme binding	GO:019899	INF	NOTCH3, NFKBIA, TTN, TGFB1, DNM2, STAT1
13	calmodulin binding	GO:005516	INF	RYR1, RYR3, GAP43, MYH2, MYH3, MYH6