MCID: MYP006
MIFTS: 59

Myopia malady

Categories: Genetic diseases, Eye diseases, Rare diseases

Aliases & Classifications for Myopia

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Aliases & Descriptions for Myopia:

Name: Myopia 11 50 39 13 68
Myopia, Susceptibility to 27
Short-Sightedness 11
 
Near-Sightedness 11
Near Vision 11

Classifications:



External Ids:

Disease Ontology11 DOID:11830
ICD1030 H52.1
ICD9CM32 367.1
SNOMED-CT62 155133003, 57190000
MeSH39 D009216
NCIt45 C102533

Summaries for Myopia

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Wikipedia:71 Near-sightedness, also known as short-sightedness and myopia, is a condition of the eye where light... more...

MalaCards based summary: Myopia, also known as myopia, susceptibility to, is related to marshall syndrome and stickler syndrome, type ii, and has symptoms including aniseikonia and aniseikonia. An important gene associated with Myopia is SCO2 (SCO2, Cytochrome C Oxidase Assembly Protein), and among its related pathways are Protein digestion and absorption and ECM proteoglycans. Affiliated tissues include eye, retina and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:11 A refractive error characterized by the inability to see farther objects clearly.

Related Diseases for Myopia

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Diseases in the Myopia family:

Myopia 14 Myopia 21, Autosomal Dominant
Myopia 8 Myopia 23, Autosomal Recessive
Myopia 9 Myopia 22, Autosomal Dominant
Myopia 10 Myopia 7
Myopia 24, Autosomal Dominant Myopia 20, Autosomal Dominant
Myopia 6 Myopia, Autosomal

Diseases related to Myopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1marshall syndrome32.6COL11A1, COL2A1
2stickler syndrome, type ii31.7COL11A1, COL2A1
3stickler syndrome29.6COL2A1, COL9A2
4deafness and myopia12.3
5degenerative myopia12.1
6epiphyseal dysplasia, multiple, with myopia and deafness12.0
7myopia 612.0
8myopia 21, autosomal dominant12.0
9myopia, high, with cataract and vitreoretinal degeneration12.0
10polydactyly, postaxial, with progressive myopia12.0
11myopia 23, autosomal recessive12.0
12myopia 22, autosomal dominant12.0
13myopia 1411.9
14myopia 811.9
15myopia 911.9
16myopia 1011.9
17myopia 711.9
18myopia 20, autosomal dominant11.9
19myopia 24, autosomal dominant11.9
20aplasia cutis congenita, high myopia, and cone-rod dysfunction11.8
21blepharoptosis, myopia, and ectopia lentis11.8
22dandy-walker malformation with mental retardation, macrocephaly, myopia, and brachytelephalangy11.7
23spondyloepiphyseal dysplasia, myopia, and sensorineural deafness11.7
24myopia, autosomal11.7
25camptodactyly, myopia, and fibrosis of the medial rectus muscle of eye11.6
26spinocerebellar degeneration with macular corneal dystrophy, congenital cataracts, and myopia11.6
27aplasia cutis myopia11.6
28optic atrophy opthalmoplegia ptosis deafness myopia11.6
29sinus node disease and myopia11.6
30myopia, x-linked11.6
31autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome11.6
32osteopenia-myopia-hearing loss-intellectual disability-facial dysmorphism syndrome11.6
33rare isolated myopia11.6
34x-linked congenital stationary night blindness11.6
35night blindness, congenital stationary , 1a, x-linked11.4
36bornholm eye disease11.4
37achromatopsia-311.4
38donnai-barrow syndrome11.4
39hamamy syndrome11.3
40knobloch syndrome11.2
41refractive error11.1
42anisometropia11.0
43retinitis pigmentosa10.9
44cohen syndrome10.9
45homocystinuria, b6-responsive and nonresponsive types10.8
46aland island eye disease10.8
47blue cone monochromacy10.8
48mousa al din al nassar syndrome10.8
49noble bass sherman syndrome10.8
50nephrotic syndrome, type 5, with or without ocular abnormalities10.7

Graphical network of the top 20 diseases related to Myopia:



Diseases related to myopia

Symptoms & Phenotypes for Myopia

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UMLS symptoms related to Myopia:


aniseikonia

MGI Mouse Phenotypes related to Myopia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.9CLDN19, COL2A1, COL9A2, FBN1, FMOD, LAMA1
2MP:00036318.7CLDN19, COL11A1, COL18A1, COL2A1, COL9A2, FBN1
3MP:00053918.3COL18A1, COL2A1, FMOD, LAMA1, NYX, OPN1LW

Drugs & Therapeutics for Myopia

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Drugs for Myopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 188)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TropicamideapprovedPhase 4, Phase 2221508-75-45593
Synonyms:
(+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
1508-75-4
5-22-09-00359 (Beilstein Handbook Reference)
AB00052120
AC-816
AC1L1KOZ
AC1Q5IFA
AR-1K6980
Akorn Brand of Tropicamide
Alcon Brand of Tropicamide
BPBio1_000303
BRD-A79672927-001-05-8
BRN 0285563
BSPBio_000275
BSPBio_002289
Bio-0810
Bistropamide
Bournonville Brand of Tropicamide
CHEMBL1200604
CID5593
CPD000058523
Cahill May Roberts Brand of Tropicamide
Chauvin Brand of Tropicamide
Colircusi Tropicamida
D00397
D014331
DB00809
DivK1c_000448
EINECS 216-140-2
EU-0101223
Epitromina
HMS1568N17
HMS1921I09
HMS2089M05
HMS2092A18
HMS501G10
I-Picamide
I06-0811
IDI1_000448
KBio1_000448
KBio2_001064
KBio2_003632
KBio2_006200
KBio3_001509
KBioGR_000873
KBioSS_001064
L001262
LS-28545
Lopac0_001223
MLS001306442
MLS002154240
Medical Ophthalmics Brand of Tropicamide
Minims tropicamide
MolPort-000-159-321
Mydral
Mydriacyl
Mydriacyl (TN)
Mydriafair
Mydriaticum
Mydrum
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
N-Ethyl-2-phenyl-N-4-[-pyridyl-methyl]hydracrylamide
N-Ethyl-N-(4-pyridylmethyl)tropamid
N-Ethyl-N-(4-pyridylmethyl)tropamide
N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
NCGC00016065-03
NCGC00016065-08
 
NCGC00024866-02
NCGC00024866-03
NCGC00024866-04
NCGC00024866-05
NCGC00024866-06
NINDS_000448
Novartis Brand of Tropicamide
Ocu Tropic
Ocu-Tropic
OcuTropic
Ocumed Brand of Tropicamide
Ocusoft Brand of Tropicamide
Opticyl
Paremyd
Pharmafair Brand of Tropicamide
Prestwick0_000228
Prestwick1_000228
Prestwick2_000228
Prestwick3_000228
Prestwick_487
Rivex Brand of Tropicamide
Ro 1-7683
SAM002564235
SMP1_000304
SMR000058523
SPBio_000872
SPBio_002196
SPECTRUM1500599
STK934612
Spectro-Cyl
Spectrum2_000936
Spectrum3_000655
Spectrum4_000377
Spectrum5_001585
Spectrum_000584
Stulln Brand 1 of Tropicamide
Stulln Brand 2 of Tropicamide
T 9778
T9778_SIGMA
TL8001101
Triaminic DM
Tropicacyl
Tropicamid
Tropicamida
Tropicamida [INN-Spanish]
Tropicamide
Tropicamide (JP15/USP/INN)
Tropicamide Alcon Brand
Tropicamide Chauvin Brand
Tropicamide Faure
Tropicamide Minims
Tropicamide Monofree
Tropicamide Monohydrochloride, (R)-Isomer
Tropicamide Monohydrochloride, (S)-Isomer
Tropicamide Novartis Brand
Tropicamide Ocumed Brand
Tropicamide Pharmafair Brand
Tropicamide Rivex Brand
Tropicamide [USAN:INN:BANJAN]
Tropicamide, (+-)-Isomer
Tropicamide, (R)-Isomer
Tropicamide, (S)-Isomer
Tropicamidum
Tropicamidum [INN-Latin]
Tropikamid
Tropimil
UNII-N0A3Z5XTC6
Visumidriatic
n-ethyl-n-(g-picolyl)tropamide
tropicamide
2
Atropineapproved, vet_approvedPhase 4, Phase 2, Phase 3, Phase 11295908-99-6, 51-55-8174174
Synonyms:
(+,-)-Tropyl tropate
(+-)-Atropine
(+-)-Hyoscyamine
(+-)-atropine
(+-)-hyoscyamine
(+/-)-Atropine
(+/-)-Hyoscyamine
(3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate
(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
(3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
(3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane
(3-exo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
(±)-atropine
(±)-hyoscyamine
1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester)
1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI)
120-29-6
1alphaH,5alphaH-Tropan-3alpha-ol
1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester)
1alphaH,5alphaH-Tropan-3beta-ol
2-Phenylhydracrylic acid 3-alpha-tropanyl ester
51-55-8
8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate
A0132_SIGMA
A2468_SIGMA
AC1L5AX3
AC1Q3XL2
ACon1_000046
AI3-60219
AKOS005137976
ATROPINE
Ambap120-29-6
Anaspaz
Atropair
Atropen
Atropen (TN)
Atropin
Atropin [German]
Atropin-flexiolen
Atropina
Atropina [Italian]
Atropine
Atropine (USP)
Atropine Care
Atropine Sulfate
Atropine Sulfate S.O.P.
Atropine [BAN]
Atropinol
Atropinum
Atropt
Atrosulf
BRD-A27290375-001-01-8
Belladenal
Bellergal-S
Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
C01479
C17H23NO3
CAS-120-29-6
CCRIS 3080
CHEBI:15742
CHEBI:15884
CHEBI:16684
CHEBI:537621
CHEBI:57858
CHEMBL1235490
 
CID174174
CPD001906768
Cytospaz
D00113
DB00572
DB04026
DL-Hyoscyamine
DL-Tropanyl 2-hydroxy-1-phenylpropionate
DL-Tropyl tropate
EINECS 200-104-8
Eyesules
FT-0082634
HMS2089A16
HSDB 2199
Hyoscyamine sulfate
I-Tropine
Isopto Atropine
Isopto-atropine
LS-7203
MEGxp0_001878
MLS000069795
MLS001148094
MLS002695888
Minims
Minims Atropine
MolPort-001-742-593
MolPort-003-986-158
Mydriasine
NCGC00016370-01
NCGC00142514-01
NCGC00142514-03
NP-010662
Neo-Diophen
OR22908
Ocu-Tropine
Protamine & Atropine
SAM002554885
SMR000058248
ST057178
ST057655
T0534
TL8000018
Tropanol
Tropic acid, 3-alpha-tropanyl ester
Tropic acid, ester with tropine
Tropine (+/-)-tropate
Tropine tropate
Tropine, tropate (ester)
Troyl tropate
Urised
[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
[(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate
[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate
a-Tropine
atropinium cation
atropinium(1+)
b eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]
beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]
bmse000649
d1-hyoscyamine
dl-Hyoscyamine
dl-Tropyltropate
dl-tropyltropate
endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
hyoscyamine
nchembio.307-comp21
tropan-3alpha-ol
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
tropan-3beta-ol
3
RanibizumabapprovedPhase 4, Phase 3, Phase 2, Phase 1474347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
4
DipivefrinapprovedPhase 49452365-63-63105
Synonyms:
( -)-2,2-Dimethylpropansaeure-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylenester
( -)-4-(1-Hydroxy-2-methylaminoethyl)-o-phenylendipivalat
(+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate
(+-)-4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate
(+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate
(RS)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat
1-(3',4'-Dipivaloyloxyphenyl)-2-methylamino-1-ethanol
1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol
2,2-Dimethylpropanoic acid 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat
4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate
4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate)
52365-63-6
AB00514686
AC1L1F6K
AKOS003662293
AKPro
BPBio1_000688
BRD-A47494775-003-03-0
BSPBio_000624
C06963
C19H29NO5
CHEBI:4646
CID3105
D02349
DB00449
Dipivalyl Epinephrine
 
Dipivefrin
Dipivefrin (USAN)
Dipivefrin HCL
Dipivefrin [USAN]
Dipivefrina
Dipivefrina [INN-Spanish]
Dipivefrine
Dipivefrine (INN)
Dipivefrinum
Dipivefrinum [INN-Latin]
Dipivéfrine
K 30081
L000915
LS-121419
NCGC00179499-01
Ophtho-Dipivefrin
Prestwick0_000632
Prestwick1_000632
Prestwick2_000632
Prestwick3_000632
Pro-Epinephrine
Propine
Propine C Cap B.I.D.
SPBio_002843
UNII-8Q1PVL543G
[2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate
dipivalyl epinephrine
dipivefrin
nchembio747-comp3
5
Bevacizumabapproved, investigationalPhase 4, Phase 3, Phase 2, Phase 11968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
6
NepafenacapprovedPhase 44178281-72-8151075
Synonyms:
2-amino-3-Benzoylbenzeneacetamide
AHR 9434
AHR-9434
AL 6515
 
AL-6515
Amfenac amide
Nepafenaco
Nepafenacum
Nevanac
7
KetorolacapprovedPhase 430474103-06-3, 66635-83-43826
Synonyms:
(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(+-)-Ketorolac
(+-)-isomer
(.+/-.)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
66635-83-4
74103-06-3
AB00053682
AC-545
AC1L1GSW
BRD-A40639672-234-05-7
C07062
CHEBI:105080
CHEMBL469
CID3826
D020910
D08104
DB00465
 
I14-2832
Ketoralac
Ketorolac
Ketorolac (INN)
Ketorolac Tromethamine
Ketorolac [INN:BAN]
Ketorolaco
Ketorolaco [Spanish]
Ketorolacum
Ketorolacum [Latin]
Kétorolac
LS-139094
Macril
MolPort-005-933-093
NCGC00185990-01
RS 37619
RS-37619
SBB067312
STL018674
Toradol (TN)
UNII-YZI5105V0L
ketorolac
rac-Ketorolac
8
Verteporfinapproved, investigationalPhase 4, Phase 3, Phase 187129497-78-5
Synonyms:
Verteporfin
 
Verteporfina
Verteporfinum
Vertéporfine
9
FluorometholoneapprovedPhase 419426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
 
Fluorometholone (JP15/USP/INN)
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml (TN)
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
10
LoteprednolapprovedPhase 45082034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
11
Bromfenacapproved, Approved July 1997Phase 44291714-94-260726
Synonyms:
2-Amino-3-(4-bromobenzoyl)benzeneacetic acid
2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
2-amino-3-(4-Bromobenzoyl)benzeneacetic acid
91714-94-2
AC1L1TSW
AC1Q5DQ7
AHR-10282
Ambap120638-55-3
BROMFENAC SODIUM
Bromfenac
Bromfenac (INN)
Bromfenac [INN]
Bromfenac sodium
Bromfenaco
Bromfenaco [Spanish]
 
Bromfenacum
Bromfenacum [Latin]
C15H12BrNO3
CHEBI:240107
CHEMBL1077
CID60726
D07541
DB00963
Duract
LS-178156
MolPort-000-883-091
UNII-864P0921DW
Xibrom
[2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid
[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate
{2-amino-3-[(4-bromophenyl)carbonyl]phenyl}acetic acid
12glucocorticoidsPhase 4, Phase 3, Phase 1, Phase 24920
13Adjuvants, AnesthesiaPhase 4, Phase 2, Phase 3, Phase 11588
14Anti-Infective AgentsPhase 4, Phase 1, Phase 221402
15Hormone AntagonistsPhase 4, Phase 3, Phase 1, Phase 212778
16TetrahydrozolinePhase 4, Phase 2, Phase 3, Phase 1593
17Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 1, Phase 212767
18Ophthalmic SolutionsPhase 4, Phase 2, Phase 3, Phase 11092
19Nucleic Acid Synthesis InhibitorsPhase 4, Phase 14855
20HormonesPhase 4, Phase 3, Phase 1, Phase 213979
21Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 1, Phase 210355
22MitomycinsPhase 4, Phase 1233
23Cholinergic AgentsPhase 4, Phase 2, Phase 3, Phase 13846
24Cholinergic AntagonistsPhase 4, Phase 2, Phase 3, Phase 11658
25Muscarinic AntagonistsPhase 4, Phase 2, Phase 3, Phase 11134
26MydriaticsPhase 4, Phase 2, Phase 3, Phase 1, Early Phase 1763
27Bronchodilator AgentsPhase 4, Phase 2, Phase 3, Phase 12856
28Autonomic AgentsPhase 4, Phase 2, Phase 3, Phase 19774
29AnestheticsPhase 4, Phase 2, Phase 3, Phase 19001
30Anti-Arrhythmia AgentsPhase 4, Phase 2, Phase 3, Phase 12969
31Anti-Asthmatic AgentsPhase 4, Phase 2, Phase 3, Phase 13369
32Neurotransmitter AgentsPhase 4, Phase 2, Phase 3, Phase 117734
33ParasympatholyticsPhase 4, Phase 2, Phase 3, Phase 11050
34Alkylating AgentsPhase 4, Phase 14694
35Anti-Bacterial AgentsPhase 4, Phase 1, Phase 210884
36Antibiotics, AntitubercularPhase 4, Phase 1, Phase 26972
37Angiogenesis InhibitorsPhase 4, Phase 3, Phase 2, Phase 14143
38Angiogenesis Modulating AgentsPhase 4, Phase 3, Phase 2, Phase 14072
39Respiratory System AgentsPhase 4, Phase 2, Phase 3, Phase 14818
40Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 3, Phase 122776
41Anti-Infective Agents, LocalPhase 4, Phase 21785
42Gastrointestinal AgentsPhase 4, Phase 1, Phase 28109
43MicronutrientsPhase 4, Phase 1, Phase 25802
44Trace ElementsPhase 4, Phase 1, Phase 25802
45Photosensitizing AgentsPhase 4, Phase 3, Phase 1476
46AnalgesicsPhase 4, Phase 311287
47Analgesics, Non-NarcoticPhase 4, Phase 36260
48Anti-Inflammatory Agents, Non-SteroidalPhase 44295
49Polyhexamethylene biguanidePhase 410
50Pharmaceutical SolutionsPhase 4, Phase 3, Phase 1, Phase 27793

Interventional clinical trials:

(show top 50)    (show all 541)
idNameStatusNCT IDPhase
1Study of Myopia Prevention in Children With Low Concentration of AtropineUnknown statusNCT00541177Phase 4
2Ranibizumab for Myopic NeovascularizationUnknown statusNCT01246089Phase 4
3Aflibercept Intravitreal Injection for Myopic Choroidal NeovascularizationUnknown statusNCT02033018Phase 4
4Multi Laser Platform Comparison Study for LASIKUnknown statusNCT00770094Phase 4
5A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIKUnknown statusNCT02071576Phase 4
6Clinical Investigation of the Bi Flex M Multifocal IOLUnknown statusNCT02338882Phase 4
7Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 SecondsCompletedNCT00564213Phase 4
8Visual Outcomes and Contrast Sensitivity After Myopic LASIKCompletedNCT01746589Phase 4
9A Comparison of PRK and LASIK for Correction of MyopiaCompletedNCT00404105Phase 4
10An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic PatientsCompletedNCT01173198Phase 4
11Bevacizumab Intravitreal for Myopic Choroidal NeovascularizationCompletedNCT00797992Phase 4
12Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens ExtractionCompletedNCT01225952Phase 4
13Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic EyesCompletedNCT01387360Phase 4
14Evaluation of the Post-LASIK Flap Thickness of the FS200 Femtosecond Laser FlapCompletedNCT01693939Phase 4
15Contralateral Comparison of Three Excimer Laser Systems in Performing LASIKCompletedNCT00821236Phase 4
16Overall Performance of a 1-day Silicone Hydrogel Lens When Habitual Soft Lens Wearers Are RefitCompletedNCT02588573Phase 4
17BIOCLEAN MPS (Multi-Purpose Solution) VII in Combination With Biofinity Lens: A Two Week Crossover StudyCompletedNCT02537730Phase 4
18The Clinical Performance of the Biofinity Contact Lens (Comfilcon A) With Two Lens Care SystemsCompletedNCT02510820Phase 4
19Clinical Performance of Hydrogel vs. Silicone Hydrogel Contact LensesCompletedNCT02131402Phase 4
20Clinical Evaluation of Daily Disposable Contact LensesCompletedNCT02097030Phase 4
21Daily Disposable Comparison StudyCompletedNCT02094677Phase 4
22Multi-center Clinical Evaluation of PC 1-Day vs 1-Day Acuvue MoistCompletedNCT02024698Phase 4
23Evaluation of Stenfilcon A Versus Etafilcon ACompletedNCT01809834Phase 4
24Clinical Performance of Stenfilcon A Versus Filcon II 3CompletedNCT01808209Phase 4
25Multi-Centre Clinical Evaluation Of Two Daily Disposable Contact LensesCompletedNCT01707238Phase 4
26Evaluation of Comfilcon A and Senofilcon A LensesCompletedNCT01695369Phase 4
27Bromday Versus Nevanac Eye Drops to Control Pain Following Photorefractive KeratectomyCompletedNCT01475877Phase 4
28Effect of Preoperative Pupil Size on Quality of Vision After Wavefront-Guided LASIKCompletedNCT00889941Phase 4
29Comparative Performance of PureVision, Acuvue Oasys and O2OptixCompletedNCT00640341Phase 4
30Efficacy of PEG-400 and Systane Artificial Tears (Alcon) on Quality of VisionCompletedNCT00627302Phase 4
31Long-term Effects of Laser Refractive SurgeryCompletedNCT00350246Phase 4
32Effects of Contact Lens Care Regimens on the Corneal EpitheliumCompletedNCT00349882Phase 4
33Investigation of Multi-Purpose Solution-Based Corneal Staining and Ocular ComfortCompletedNCT00349843Phase 4
34Daily Wear Corneal Infiltrative Event StudyCompletedNCT00937105Phase 4
35Visual Performance After RESTOR ImplantationCompletedNCT01065064Phase 4
36Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular SurfaceCompletedNCT01250925Phase 4
37Corneal and Conjunctival Sensitivity and Staining StudyCompletedNCT00455455Phase 4
38Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRKCompletedNCT00347204Phase 4
39Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).CompletedNCT00620893Phase 4
40Evaluation of 3 Intraocular Lenses Following Lens ExtractionCompletedNCT01122576Phase 4
41PreView PHP Preferential Hyperacuity Perimeter for the Detection of Choroidal NeovascularizationCompletedNCT00358345Phase 4
42Visual Outcome, Cylinder Correction and Patient Satisfaction After Implantation of AT LISA Tri Toric 939MP Intraocular LensesCompletedNCT02985723Phase 4
43Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL)CompletedNCT01210807Phase 4
44Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLsCompletedNCT00366587Phase 4
45Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision MultifocalCompletedNCT01591499Phase 4
46Effect of Orthokeratology Versus Spectacles on Myopia Progression in Chinese Children: A Crossover TrialRecruitingNCT02186184Phase 4
47Comparison of Next Generation Laser Techniques of Myopia Correction: iDesign vs. SMILERecruitingNCT03001401Phase 4
48A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIKRecruitingNCT01977807Phase 4
49High Resolution Wavefront-guided vs. Wavefront Optimized LASIKRecruitingNCT02565537Phase 4
50DAILIES TOTAL1 Versus ACUVUE TruEyeRecruitingNCT02347631Phase 4

Search NIH Clinical Center for Myopia


Cochrane evidence based reviews: myopia

Genetic Tests for Myopia

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Genetic tests related to Myopia:

id Genetic test Affiliating Genes
1 Myopia27

Anatomical Context for Myopia

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MalaCards organs/tissues related to Myopia:

36
Eye, Retina, Testes, Endothelial, Bone, Heart, Cortex

Publications for Myopia

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Articles related to Myopia:

(show top 50)    (show all 1015)
idTitleAuthorsYear
1
Mutations in DZIP1 and XYLT1 are associated with nonsyndromic early onset high myopia in the Korean population. (28085539)
2017
2
Evaluation of genome-wide susceptibility loci for high myopia in a Han Chinese population. (28085524)
2017
3
A Prospective Study to Compare Visual Outcomes Between Wavefront-optimized and Topography-guided Ablation Profiles in Contralateral Eyes With Myopia. (28068440)
2017
4
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression. (28063778)
2017
5
Update on Orthokeratology in Managing Progressive Myopia in Children: Efficacy, Mechanisms, and Concerns. (28092397)
2017
6
Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera. (28055099)
2017
7
Spontaneous resolution of foveal detachment in traction maculopathy in high myopia unrelated to posterior vitreous detachment. (26868376)
2016
8
Kappa angles in different positions in patients with myopia during LASIK. (27162734)
2016
9
Choroidal Neovascularization Secondary to Myopia, Infection and Inflammation. (26501802)
2016
10
Myopia and Outdoor Exposures. (27618416)
2016
11
Myopia is inversely associated with the prevalence of diabetic retinopathy in the South Korean Population. (27640007)
2016
12
Different roles of retinal dopamine in albino Guinea pig myopia. (28041966)
2016
13
Clinical Characterization of LRPAP1-Related Pediatric High Myopia. (26271838)
2016
14
Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia. (27654415)
2016
15
Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis. (27588274)
2016
16
Association of COL1A1 polymorphism with high myopia: a Meta-analysis. (27162737)
2016
17
Association between Ocular Axial Length-Related Genes and High Myopia in a Han Chinese Population. (26485405)
2016
18
Identifying Children at Risk of High Myopia Using Population Centile Curves of Refraction. (28030593)
2016
19
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium. (27174397)
2016
20
Effects of Background Lighting Color and Movement Distance on Reaching Times Among Participants With Low Vision, Myopia, and Normal Vision. (27166331)
2016
21
Identification of novel X-linked gain-of-function RPGR-ORF15 mutation in Italian family with retinitis pigmentosa and pathologic myopia. (27995965)
2016
22
A control-matched comparison of flap off and flap on laser-assisted subepithelial keratectomy (LASEK) for the treatment of myopia and myopic astigmatism. (26949353)
2016
23
Inverted Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment in High Myopia. (27174666)
2016
24
Accommodative spasm might influence surgical planning and outcomes in acute acquired distance esotropia in myopia. (27515204)
2016
25
When do myopia genes have their effect? Comparison of genetic risks between children and adults. (27611182)
2016
26
Long-Term Comparison of Posterior Chamber Phakic Intraocular Lens With and Without a Central Hole (Hole ICL and Conventional ICL) Implantation for Moderate to High Myopia and Myopic Astigmatism: Consort-Compliant Article. (27057883)
2016
27
Risk Factors for Developing Myopia among Schoolchildren in Yerevan and Gegharkunik Province, Armenia. (28032802)
2016
28
Re: Chia etA al.: Five-year clinical trial on atropine for the treatment of myopia 2: myopia control with atropine 0.01% eyedrops (Ophthalmology 2016;123:391-9). (27210609)
2016
29
Association of Insulin-Like Growth Factor-1 Gene Polymorphisms with Different Types of Myopia in Egyptian Patients. (27167306)
2016
30
Bidirectional Expression of Metabolic, Structural, and Immune Pathways in Early Myopia and Hyperopia. (27625591)
2016
31
Exome sequencing identified null mutations in LOXL3 associated with early-onset high myopia. (26957899)
2016
32
Development of Experimental Myopia in Chicks in a Natural Environment. (27618415)
2016
33
Novel TRPM1 mutations in two Chinese families with early-onset high myopia, with or without complete congenital stationary night blindness. (27803854)
2016
34
Early outcomes after small incision lenticule extraction and photorefractive keratectomy for correction of high myopia. (27601090)
2016
35
Transepithelial Photorefractive Keratectomy for Low to Moderate Myopia in Comparison with Conventional Photorefractive Keratectomy. (27994803)
2016
36
Methodology and Myopia? Some Praise, a Problem, and a Plea. (27649832)
2016
37
The investigation on the role of mitochondrial fusion protein 1 in the development of myopia. (27609161)
2016
38
Posterior scleral reinforcement for the treatment of pathological myopia. (27162733)
2016
39
Controversial opinion: evaluation of EGR1 and LAMA2 loci for high myopia in Chinese populations. (26984843)
2016
40
Decreased sleep quality in high myopia children. (27650408)
2016
41
Effectiveness study of atropine for progressive myopia in Europeans. (27101751)
2016
42
Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia. (27654417)
2016
43
Combined Special Capsular Tension Ring and Toric IOL Implantation for Management of Astigmatism and High Axial Myopia with Cataracts. (28005433)
2016
44
Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice. (27622715)
2016
45
High Myopia Associated with Triple X Syndrome. (27928398)
2016
46
Dry Eye after Small Incision Lenticule Extraction (SMILE) versus Femtosecond Laser-Assisted in Situ Keratomileusis (FS-LASIK) for Myopia: A Meta-Analysis. (27992482)
2016
47
Myopia Development Among Young Schoolchildren: The Myopia Investigation Study in Taipei. (28002845)
2016
48
EPIDEMIC OF PATHOLOGIC MYOPIA: What Can Laboratory Studies and Epidemiology Tell Us? (27617538)
2016
49
HIGH MYOPIA AND DIABETIC RETINOPATHY: A Contralateral Eye Study in Diabetic Patients With High Myopic Anisometropia. (27749693)
2016
50
Viscoat Assisted Inverted Internal Limiting Membrane Flap Technique for Large Macular Holes Associated with High Myopia. (27047686)
2016

Variations for Myopia

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Clinvar genetic disease variations for Myopia:

5
id Gene Variation Type Significance SNP ID Assembly Location
146;XY;t(5;15)(q11.2;q24)TranslocationPathogenicChr na, -1: -1

Expression for genes affiliated with Myopia

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Search GEO for disease gene expression data for Myopia.

Pathways for genes affiliated with Myopia

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GO Terms for genes affiliated with Myopia

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Cellular components related to Myopia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen trimerGO:000558110.6COL11A1, COL18A1, COL2A1
2microfibrilGO:000152710.5ADAMTS10, FBN1
3endoplasmic reticulum lumenGO:000578810.1COL11A1, COL18A1, COL2A1, COL9A2, P3H2
4basement membraneGO:000560410.1COL18A1, COL2A1, FBN1, LAMA1, P3H2
5extracellular matrixGO:00310129.3ADAMTS10, COL11A1, COL18A1, COL2A1, FBN1, FMOD
6extracellular regionGO:00055769.0COL11A1, COL18A1, COL2A1, COL9A2, FBN1, FMOD
7proteinaceous extracellular matrixGO:00055788.5ADAMTS17, COL11A1, COL2A1, COL9A2, FBN1, FMOD

Biological processes related to Myopia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cartilage condensationGO:000150210.8COL11A1, COL2A1
2proteoglycan metabolic processGO:000602910.8COL11A1, COL2A1
3inner ear morphogenesisGO:004247210.6COL11A1, COL2A1, SLITRK6
4sensory perception of soundGO:000760510.5COL11A1, COL2A1, SLITRK6
5collagen catabolic processGO:003057410.5COL11A1, COL18A1, COL2A1
6collagen fibril organizationGO:003019910.4COL11A1, COL2A1, FMOD
7skeletal system developmentGO:000150110.4COL2A1, COL9A2, FBN1
8extracellular matrix organizationGO:00301989.7COL11A1, COL18A1, COL2A1, COL9A2, FBN1, LAMA1
9visual perceptionGO:00076018.5CLDN19, COL11A1, COL18A1, COL2A1, NYX, OPN1LW

Molecular functions related to Myopia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:003002010.0COL2A1, COL9A2
2extracellular matrix structural constituentGO:00052019.9COL11A1, FBN1, LAMA1

Sources for Myopia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet