MCID: MYP006
MIFTS: 56

Myopia malady

Categories: Eye diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Myopia

Aliases & Descriptions for Myopia:

Name: Myopia 12 52 42 14 69
Myopia, Susceptibility to 29
Short-Sightedness 12
Near-Sightedness 12
Near Vision 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11830
ICD10 33 H52.1
ICD9CM 35 367.1
MeSH 42 D009216
NCIt 47 C102533
SNOMED-CT 64 155133003 57190000
UMLS 69 C0027092

Summaries for Myopia

Disease Ontology : 12 A refractive error characterized by the inability to see farther objects clearly.

MalaCards based summary : Myopia, also known as myopia, susceptibility to, is related to epiphyseal dysplasia, multiple, with myopia and deafness and marshall syndrome, and has symptoms including aniseikonia An important gene associated with Myopia is SCO2 (SCO2, Cytochrome C Oxidase Assembly Protein), and among its related pathways/superpathways is Degradation of the extracellular matrix. The drugs Atropine and Tropicamide have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotype is vision/eye.

Wikipedia : 71 Near-sightedness, also known as short-sightedness and myopia, is a condition of the eye where light... more...

Related Diseases for Myopia

Diseases in the Myopia family:

Myopia 14 Myopia 21, Autosomal Dominant
Myopia 8 Myopia 23, Autosomal Recessive
Myopia 9 Myopia 22, Autosomal Dominant
Myopia 10 Myopia 7
Myopia 24, Autosomal Dominant Myopia 20, Autosomal Dominant
Myopia 6 Myopia, Autosomal
Myopia 25, Autosomal Dominant

Diseases related to Myopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
id Related Disease Score Top Affiliating Genes
1 epiphyseal dysplasia, multiple, with myopia and deafness 33.3 COL11A1 COL2A1 FMOD
2 marshall syndrome 32.1 COL11A1 COL2A1
3 deafness and myopia 12.2
4 degenerative myopia 12.1
5 myopia 6 12.0
6 myopia 21, autosomal dominant 12.0
7 myopia, high, with cataract and vitreoretinal degeneration 12.0
8 polydactyly, postaxial, with progressive myopia 12.0
9 myopia 23, autosomal recessive 12.0
10 myopia 22, autosomal dominant 12.0
11 myopia 8 11.9
12 myopia 14 11.9
13 myopia 9 11.9
14 myopia 7 11.9
15 myopia 10 11.9
16 myopia 20, autosomal dominant 11.9
17 myopia 24, autosomal dominant 11.9
18 myopia 25, autosomal dominant 11.9
19 aplasia cutis congenita, high myopia, and cone-rod dysfunction 11.8
20 blepharoptosis, myopia, and ectopia lentis 11.8
21 dandy-walker malformation with mental retardation, macrocephaly, myopia, and brachytelephalangy 11.7
22 spondyloepiphyseal dysplasia, myopia, and sensorineural deafness 11.7
23 myopia, autosomal 11.7
24 x-linked congenital stationary night blindness 11.6
25 osteopenia-myopia-hearing loss-intellectual disability-facial dysmorphism syndrome 11.6
26 rare isolated myopia 11.6
27 aplasia cutis myopia 11.6
28 sinus node disease and myopia 11.6
29 camptodactyly, myopia, and fibrosis of the medial rectus muscle of eye 11.6
30 myopia, x-linked 11.6
31 spinocerebellar degeneration with macular corneal dystrophy, congenital cataracts, and myopia 11.6
32 optic atrophy opthalmoplegia ptosis deafness myopia 11.6
33 autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome 11.6
34 night blindness, congenital stationary , 1a, x-linked 11.5
35 bornholm eye disease 11.4
36 achromatopsia-3 11.4
37 donnai-barrow syndrome 11.4
38 hamamy syndrome 11.3
39 knobloch syndrome 11.3
40 refractive error 11.0
41 anisometropia 11.0
42 retinitis pigmentosa 10.9
43 cohen syndrome 10.9
44 aland island eye disease 10.8
45 blue cone monochromacy 10.8
46 mousa al din al nassar syndrome 10.8
47 noble bass sherman syndrome 10.8
48 wagner syndrome 1 10.7
49 gyrate atrophy of choroid and retina with or without ornithinemia 10.7
50 homocystinuria, b6-responsive and nonresponsive types 10.7

Graphical network of the top 20 diseases related to Myopia:



Diseases related to Myopia

Symptoms & Phenotypes for Myopia

UMLS symptoms related to Myopia:


aniseikonia

MGI Mouse Phenotypes related to Myopia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.17 COL2A1 FMOD MYOC NYX PAX6 PRIMPOL

Drugs & Therapeutics for Myopia

Drugs for Myopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 184)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 5908-99-6, 51-55-8 174174
2
Tropicamide Approved Phase 4,Phase 2 1508-75-4 5593
3
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1 347396-82-1 459903
4
Levofloxacin Approved, Investigational Phase 4,Phase 1,Phase 2 100986-85-4 149096
5
Ofloxacin Approved Phase 4,Phase 1,Phase 2 82419-36-1 4583
6
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
7
Dipivefrin Approved Phase 4 52365-63-6 3105
8
Nepafenac Approved Phase 4 78281-72-8 151075
9
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
10
Verteporfin Approved, Investigational Phase 4,Phase 3,Phase 1 129497-78-5
11
Povidone-iodine Approved Phase 4 25655-41-8
12
Fluorometholone Approved Phase 4 426-13-1 9878
13
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
14
Bromfenac Approved July 1997 Phase 4 91714-94-2 60726
15 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 3,Phase 1
16 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
17 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Cholinergic Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Cholinergic Antagonists Phase 4,Phase 2,Phase 3,Phase 1
23 Muscarinic Antagonists Phase 4,Phase 2,Phase 3,Phase 1
24 Mydriatics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
25 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Parasympatholytics Phase 4,Phase 2,Phase 3,Phase 1
27 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
29 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
30 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Alkylating Agents Phase 4,Phase 1
32 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
33 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
34 Mitomycins Phase 4,Phase 1
35 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1
36 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
37 Ophthalmic Solutions Phase 4,Phase 2,Phase 3,Phase 1
38 Tetrahydrozoline Phase 4,Phase 2,Phase 3,Phase 1
39 Anti-Infective Agents Phase 4,Phase 1,Phase 2
40 glucocorticoids Phase 4,Phase 3,Phase 1,Phase 2
41 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
42 Hormones Phase 4,Phase 3,Phase 1,Phase 2
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
44
Hydrogen peroxide Phase 4 7722-84-1 784
45 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
46 Polyhexamethylene biguanide Phase 4
47 Analgesics Phase 4,Phase 3
48 Analgesics, Non-Narcotic Phase 4,Phase 3
49 Anti-Inflammatory Agents, Non-Steroidal Phase 4
50 Antirheumatic Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 572)
id Name Status NCT ID Phase
1 Study of Myopia Prevention in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4
2 Ranibizumab for Myopic Neovascularization Unknown status NCT01246089 Phase 4
3 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4
4 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
5 Multi Laser Platform Comparison Study for LASIK Unknown status NCT00770094 Phase 4
6 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIK Unknown status NCT02071576 Phase 4
7 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
8 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
9 Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds Completed NCT00564213 Phase 4
10 Visual Outcomes and Contrast Sensitivity After Myopic LASIK Completed NCT01746589 Phase 4
11 A Comparison of PRK and LASIK for Correction of Myopia Completed NCT00404105 Phase 4
12 An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic Patients Completed NCT01173198 Phase 4
13 Bevacizumab Intravitreal for Myopic Choroidal Neovascularization Completed NCT00797992 Phase 4
14 Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction Completed NCT01225952 Phase 4
15 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
16 Evaluation of the Post-LASIK Flap Thickness of the FS200 Femtosecond Laser Flap Completed NCT01693939 Phase 4
17 Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK Completed NCT00821236 Phase 4
18 Overall Performance of a 1-day Silicone Hydrogel Lens When Habitual Soft Lens Wearers Are Refit Completed NCT02588573 Phase 4
19 BIOCLEAN MPS (Multi-Purpose Solution) VII in Combination With Biofinity Lens: A Two Week Crossover Study Completed NCT02537730 Phase 4
20 Clinical Evaluation of Daily Disposable Contact Lenses Completed NCT02097030 Phase 4
21 Daily Disposable Comparison Study Completed NCT02094677 Phase 4
22 Multi-center Clinical Evaluation of PC 1-Day vs 1-Day Acuvue Moist Completed NCT02024698 Phase 4
23 Evaluation of Stenfilcon A Versus Etafilcon A Completed NCT01809834 Phase 4
24 Clinical Performance of Stenfilcon A Versus Filcon II 3 Completed NCT01808209 Phase 4
25 Multi-Centre Clinical Evaluation Of Two Daily Disposable Contact Lenses Completed NCT01707238 Phase 4
26 Evaluation of Comfilcon A and Senofilcon A Lenses Completed NCT01695369 Phase 4
27 Bromday Versus Nevanac Eye Drops to Control Pain Following Photorefractive Keratectomy Completed NCT01475877 Phase 4
28 Effect of Preoperative Pupil Size on Quality of Vision After Wavefront-Guided LASIK Completed NCT00889941 Phase 4
29 Comparative Performance of PureVision, Acuvue Oasys and O2Optix Completed NCT00640341 Phase 4
30 Efficacy of PEG-400 and Systane Artificial Tears (Alcon) on Quality of Vision Completed NCT00627302 Phase 4
31 Long-term Effects of Laser Refractive Surgery Completed NCT00350246 Phase 4
32 Effects of Contact Lens Care Regimens on the Corneal Epithelium Completed NCT00349882 Phase 4
33 Investigation of Multi-Purpose Solution-Based Corneal Staining and Ocular Comfort Completed NCT00349843 Phase 4
34 Daily Wear Corneal Infiltrative Event Study Completed NCT00937105 Phase 4
35 Visual Performance After RESTOR Implantation Completed NCT01065064 Phase 4
36 Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface Completed NCT01250925 Phase 4
37 Corneal and Conjunctival Sensitivity and Staining Study Completed NCT00455455 Phase 4
38 Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK Completed NCT00347204 Phase 4
39 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK). Completed NCT00620893 Phase 4
40 Evaluation of 3 Intraocular Lenses Following Lens Extraction Completed NCT01122576 Phase 4
41 PreView PHP Preferential Hyperacuity Perimeter for the Detection of Choroidal Neovascularization Completed NCT00358345 Phase 4
42 Visual Outcome, Cylinder Correction and Patient Satisfaction After Implantation of AT LISA Tri Toric 939MP Intraocular Lenses Completed NCT02985723 Phase 4
43 Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL) Completed NCT01210807 Phase 4
44 Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs Completed NCT00366587 Phase 4
45 Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision Multifocal Completed NCT01591499 Phase 4
46 Effect of Orthokeratology Versus Spectacles on Myopia Progression in Chinese Children: A Crossover Trial Recruiting NCT02186184 Phase 4
47 Comparison of Next Generation Laser Techniques of Myopia Correction: iDesign vs. SMILE Recruiting NCT03001401 Phase 4
48 A Prospective Study To Evaluate The Raindrop Near Vision Inlay In Presybopic Patients Treated With Mitomycin C Following Femtosecond Flap Creation. Recruiting NCT03101501 Phase 4
49 A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation Recruiting NCT03126877 Phase 4
50 Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization Recruiting NCT03042871 Phase 4

Search NIH Clinical Center for Myopia

Cochrane evidence based reviews: myopia

Genetic Tests for Myopia

Genetic tests related to Myopia:

id Genetic test Affiliating Genes
1 Myopia 29

Anatomical Context for Myopia

MalaCards organs/tissues related to Myopia:

39
Eye, Retina, Endothelial, Testes, Heart, Liver, Cortex

Publications for Myopia

Articles related to Myopia:

(show top 50) (show all 1021)
id Title Authors Year
1
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression. ( 28063778 )
2017
2
Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera. ( 28055099 )
2017
3
Evaluation of genome-wide susceptibility loci for high myopia in a Han Chinese population. ( 28085524 )
2017
4
The role of microRNAs in myopia. ( 27837278 )
2017
5
Mutations in DZIP1 and XYLT1 are associated with nonsyndromic early onset high myopia in the Korean population. ( 28085539 )
2017
6
A Prospective Study to Compare Visual Outcomes Between Wavefront-optimized and Topography-guided Ablation Profiles in Contralateral Eyes With Myopia. ( 28068440 )
2017
7
Update on Orthokeratology in Managing Progressive Myopia in Children: Efficacy, Mechanisms, and Concerns. ( 28092397 )
2017
8
Effects of Background Lighting Color and Movement Distance on Reaching Times Among Participants With Low Vision, Myopia, and Normal Vision. ( 27166331 )
2016
9
Effectiveness of Toric Orthokeratology in the Treatment of Patients with Combined Myopia and Astigmatism. ( 27980362 )
2016
10
Different roles of retinal dopamine in albino Guinea pig myopia. ( 28041966 )
2016
11
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium. ( 27174397 )
2016
12
Pseudoduplication of the optic disc in moderate myopia. ( 28003787 )
2016
13
Education-Related Parameters in High Myopia: Adults versus School Children. ( 27152764 )
2016
14
A control-matched comparison of flap off and flap on laser-assisted subepithelial keratectomy (LASEK) for the treatment of myopia and myopic astigmatism. ( 26949353 )
2016
15
Identifying Children at Risk of High Myopia Using Population Centile Curves of Refraction. ( 28030593 )
2016
16
Combined Special Capsular Tension Ring and Toric IOL Implantation for Management of Astigmatism and High Axial Myopia with Cataracts. ( 28005433 )
2016
17
Inverted Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment in High Myopia. ( 27174666 )
2016
18
Early outcomes after small incision lenticule extraction and photorefractive keratectomy for correction of high myopia. ( 27601090 )
2016
19
Posterior chamber collagen copolymer phakic intraocular lens with a central hole for moderate-to-high myopia: First experience in China. ( 27603356 )
2016
20
Refractive Outcome of Cataract Surgery in Eyes With Prior Trabeculectomy: Risk Factors for Postoperative Myopia. ( 27661991 )
2016
21
Eye exercises of acupoints: their impact on myopia and visual symptoms in Chinese rural children. ( 27599547 )
2016
22
Re: Chia etA al.: Five-year clinical trial on atropine for the treatment of myopia 2: myopia control with atropine 0.01% eyedrops (Ophthalmology 2016;123:391-9). ( 27210609 )
2016
23
Single-step transepithelial photorefractive keratectomy in myopia and astigmatism: 18-month follow-up. ( 27956283 )
2016
24
Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia. ( 28003976 )
2016
25
Long-Term Observation of Triplex Surgery for Cataract after Phakic 6H Implantation for Super High Myopia. ( 27190642 )
2016
26
Association between Ocular Axial Length-Related Genes and High Myopia in a Han Chinese Population. ( 26485405 )
2016
27
Long-term Results of Small-incision Lenticule Extraction in High Myopia. ( 28058160 )
2016
28
Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice. ( 27622715 )
2016
29
Association between SCO2 mutation and extreme myopia in Japanese patients. ( 27052445 )
2016
30
Abnormal pigment epithelium-derived factor processing in progressive myopia. ( 27590659 )
2016
31
Accommodative spasm might influence surgical planning and outcomes in acute acquired distance esotropia in myopia. ( 27515204 )
2016
32
Myopia Development Among Young Schoolchildren: The Myopia Investigation Study in Taipei. ( 28002845 )
2016
33
Effects of carbomer eye drops in combination with orthokeratology lens in treating adolescent myopia. ( 28078849 )
2016
34
Corneal Curvature Radius in Myopia of Schoolchildren Versus Adult Myopia. ( 27100659 )
2016
35
Controversial opinion: evaluation of EGR1 and LAMA2 loci for high myopia in Chinese populations. ( 26984843 )
2016
36
Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia. ( 27654417 )
2016
37
Visual and Refractive Outcomes of Photorefractive Keratectomy and Small Incision Lenticule Extraction (SMILE) for Myopia. ( 27598730 )
2016
38
Viscoat Assisted Inverted Internal Limiting Membrane Flap Technique for Large Macular Holes Associated with High Myopia. ( 27047686 )
2016
39
Posterior scleral reinforcement for the treatment of pathological myopia. ( 27162733 )
2016
40
The investigation on the role of mitochondrial fusion protein 1 in the development of myopia. ( 27609161 )
2016
41
Methodology and Myopia? Some Praise, a Problem, and a Plea. ( 27649832 )
2016
42
Association of COL1A1 polymorphism with high myopia: a Meta-analysis. ( 27162737 )
2016
43
EPIDEMIC OF PATHOLOGIC MYOPIA: What Can Laboratory Studies and Epidemiology Tell Us? ( 27617538 )
2016
44
GORE-TEX VASCULAR GRAFT FOR MACULAR BUCKLING IN HIGH MYOPIA EYES. ( 27984549 )
2016
45
Clinical Characterization of LRPAP1-Related Pediatric High Myopia. ( 26271838 )
2016
46
Association of Insulin-Like Growth Factor-1 Gene Polymorphisms with Different Types of Myopia in Egyptian Patients. ( 27167306 )
2016
47
Dry Eye after Small Incision Lenticule Extraction (SMILE) versus Femtosecond Laser-Assisted in Situ Keratomileusis (FS-LASIK) for Myopia: A Meta-Analysis. ( 27992482 )
2016
48
Exome sequencing identified null mutations in LOXL3 associated with early-onset high myopia. ( 26957899 )
2016
49
Early changes to dry eye and ocular surface after small-incision lenticule extraction for myopia. ( 27162732 )
2016
50
ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome. ( 28057946 )
2016

Variations for Myopia

ClinVar genetic disease variations for Myopia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 COL2A1 NM_033150.2(COL2A1): c.2503C> T (p.Arg835Cys) single nucleotide variant Pathogenic rs121912882 GRCh37 Chromosome 12, 48373317: 48373317
2 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
3 FBN1 NM_000138.4(FBN1): c.6800A> T (p.Asn2267Ile) single nucleotide variant Pathogenic rs1057518812 GRCh37 Chromosome 15, 48722939: 48722939
4 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh37 Chromosome 15, 48826296: 48826299

Expression for Myopia

Search GEO for disease gene expression data for Myopia.

Pathways for Myopia

Pathways related to Myopia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 COL11A1 COL2A1 FBN1 FMOD P3H2 P4HA2

GO Terms for Myopia

Cellular components related to Myopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.55 COL11A1 COL2A1 FBN1 P3H2 P4HA2
2 basement membrane GO:0005604 9.43 COL2A1 FBN1 P3H2
3 extracellular matrix GO:0031012 9.43 ADAMTS17 COL11A1 COL2A1 FBN1 FMOD MYOC
4 proteinaceous extracellular matrix GO:0005578 9.17 ADAMTS17 COL11A1 COL2A1 FBN1 FMOD MYOC

Biological processes related to Myopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 9.65 COL11A1 COL2A1 SLITRK6
2 axonogenesis GO:0007409 9.61 FMOD PAX6 SLITRK6
3 inner ear morphogenesis GO:0042472 9.58 COL11A1 COL2A1 SLITRK6
4 camera-type eye development GO:0043010 9.54 FBN1 PAX6 SLITRK6
5 cartilage condensation GO:0001502 9.46 COL11A1 COL2A1
6 collagen fibril organization GO:0030199 9.33 COL11A1 COL2A1 FMOD
7 proteoglycan metabolic process GO:0006029 9.32 COL11A1 COL2A1
8 peptidyl-proline hydroxylation GO:0019511 9.26 P3H2 P4HA2
9 eye development GO:0001654 9.13 PAX6 SCO2 SLC39A5
10 visual perception GO:0007601 9.1 COL11A1 COL2A1 NYX PAX6 RDH8 SLITRK6

Molecular functions related to Myopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 L-ascorbic acid binding GO:0031418 8.96 P3H2 P4HA2
2 extracellular matrix structural constituent GO:0005201 8.8 COL11A1 COL2A1 FBN1

Sources for Myopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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