MCID: MYP006
MIFTS: 40

Myopia malady

Genetic diseases, Eye diseases, Rare diseases categories
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Summaries for Myopia

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33MalaCards
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MalaCards: Myopia, also known as near-sightedness, is related to myopia 6 and astigmatism. An important gene associated with Myopia is ZNF644 (zinc finger protein 644). Affiliated tissues include eye, endothelial and retina.

Aliases & Classifications for Myopia

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Sources:
8Disease Ontology, 62UMLS, 27ICD9CM, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

myopia 8 62
near-sightedness 8
near vision 8


External Ids:

Disease Ontology8 DOID:11830
ICD9CM27 367.1
SNOMED-CT58 57190000, 155133003
MeSH35 D009216

Related Diseases for Myopia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myopia 6 family:

myopia Myopia 14
Myopia 12 Myopia 8
Myopia 9 Myopia 11
Myopia 16 Myopia 19
Myopia 17 Myopia 10
Myopia 15 Myopia 7
Myopia-3 Myopia 18
Myopia 5 Myopia-2
Myopia 13 Myopia-1

Diseases related to Myopia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1myopia 630.6FMOD, ZNF644, NYX
2astigmatism10.7
3hyperopia10.6
4choroiditis10.6
5retinitis10.6
6refractive error10.6
7glaucoma10.5
8degenerative myopia10.5
9cataract10.4
10polydactyly myopia syndrome10.4
11macular holes10.3
12open-angle glaucoma10.3
13esotropia10.3
14retinal detachment10.3
15amblyopia10.3
16blindness10.3
17primary open angle glaucoma10.3
18blepharoptosis myopia ectopia lentis10.3
19anisometropia10.2
20congenital stationary night blindness10.2
21night blindness10.2
22strabismus10.2
23presbyopia10.2
24coloboma10.2
25retinoschisis10.2
26x-linked congenital stationary night blindness10.2
27aplasia cutis myopia10.2
28sinus node disease and myopia10.2
29endotheliitis10.2
30aniseikonia10.2
31corneal ectasia10.1
32donnai-barrow syndrome10.1
33dandy-walker malformation with mental retardation, macrocephaly, myopia and brachytelephalangy10.1
34myopia 22, autosomal dominant10.1
35x-linked cone dysfunction syndrome with myopia10.1
36exotropia10.1
37eye disease10.1
38keratoconus10.1
39myopia 21, autosomal dominant10.1
40epiphyseal dysplasia, multiple, with myopia and deafness10.1
41myopia 1310.1
42facial dysmorphism - macrocephaly - myopia - dandy-walker malformation10.1
43gyrate atrophy10.0
44retinopathy of prematurity10.0
45chorioretinitis10.0
46corneal dystrophy10.0
47retinal degeneration10.0
48scleritis10.0
49anophthalmia or microphthalmia, retinal dystrophy and/or myopia associated with brain anomalies10.0
50noble bass sherman syndrome10.0

Graphical network of the top 20 diseases related to Myopia:



Diseases related to myopia

Symptoms for Myopia

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Drugs & Therapeutics for Myopia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Myopia

Search NIH Clinical Center for Myopia

Genetic Tests for Myopia

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Anatomical Context for Myopia

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Sources:
33MalaCards
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MalaCards organs/tissues related to Myopia:

33
Eye, Endothelial, Retina, Testes, Heart, Cortex

Animal Models for Myopia or affiliated genes

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Publications for Myopia

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Sources:
52PubMed
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Articles related to Myopia:

(show top 50)    (show all 830)
idTitleAuthorsYear
1
Correlation between central corneal thickness and myopia in Taiwan. (24388054)
2014
2
Peripheral optical quality and myopia progression in children. (24253497)
2014
3
Measurement of Scleral Thickness using Swept-Source Optical Coherence Tomography in Open-Angle Glaucoma Patients with Myopia. (24412142)
2014
4
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
5
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
6
Peripheral defocus and myopia progression in myopic children randomly assigned to wear single vision and progressive addition lenses. (23838771)
2013
7
Clear lens phacoemulsification combined with vitrectomy to correct high myopia: four years of follow-up. (23257681)
2013
8
Effect of myopia and age on optic disc margin anatomy within the parapapillary atrophy area. (23851575)
2013
9
Heritability of myopia and ocular biometrics in Koreans: the healthy twin study. (23620424)
2013
10
The effect of the Chinese Cultural Revolution and Great Leap Forward on the prevalence of myopia. (24197389)
2013
11
Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. (23933737)
2013
12
Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization. (23533702)
2013
13
Myopia control with orthokeratology contact lenses in Spain: a comparison of vision-related quality-of-life measures between orthokeratology contact lenses and single-vision spectacles. (23392299)
2013
14
Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx(Ar) flex and comparison with a retrospective study of FS-laser in situ keratomileusis. (22512839)
2013
15
Inverse relationship between macular pigment optical density and axial length in Chinese subjects with myopia. (23224230)
2013
16
A contralateral, randomized comparison of optimized prolate ablation and conventional LASIK for myopia with the NIDEK excimer laser platform. (22767164)
2012
17
Baseline characteristics of nearwork-induced transient myopia. (23187872)
2012
18
The impact of parental myopia on myopia in Chinese children: population-based evidence. (22922777)
2012
19
Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01% doses (Atropine for the Treatment of Myopia 2). (21963266)
2012
20
Ten SNPs of PAX6, Lumican, and MYOC genes are not associated with high myopia in Han Chinese. (22809227)
2012
21
High myopia as a risk factor in primary open angle glaucoma. (23275912)
2012
22
On the dangers of methodolatry, moral hazard and myopia in research. (22176663)
2012
23
Acquired optic nerve and peripapillary pits in pathologic myopia. (22494632)
2012
24
Prevalence of myopia in a population with malocclusions. (23046255)
2012
25
Prevalence of myopia and its association with diabetic retinopathy in subjects with type II diabetes mellitus: A population-based study. (22993463)
2012
26
Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese. (21095009)
2011
27
Nature and nurture: the complex genetics of myopia and refractive error. (21155761)
2011
28
A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese. (21421876)
2011
29
Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. (21640322)
2011
30
Pigmented free-floating vitreous cyst in a patient with high myopia and uveal coloboma simulating choroidal melanoma. (21485975)
2011
31
Age-related changes of phoria myopia in patients with intermittent exotropia. (19184303)
2009
32
Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. (19836009)
2009
33
Myocilin polymorphisms and high myopia in subjects of European origin. (19180258)
2009
34
Linkage analysis of high myopia susceptibility locus in 26 families. (19122830)
2008
35
Prevalence of myopia and hyperopia among urban and rural schoolchildren in Poland. (19127805)
2008
36
Pupillography of relative afferent pupillary defects in amblyopia associated with peripapillary myelinated nerve fibers and myopia. (18825905)
2008
37
Active cyclotorsion error correction during LASIK for myopia and myopic astigmatism with the NIDEK EC-5000 CX III laser. (18047004)
2007
38
Evidence for delayed presbyopia after photorefractive keratectomy for myopia. (16650666)
2006
39
The role of the retinal pigment epithelium in eye growth regulation and myopia: a review. (16079001)
2005
40
X-linked high myopia associated with cone dysfunction. (15197065)
2004
41
Fixation linked hypotropia in high myopia. A report of two similar cases. (12597767)
2003
42
Myopia and models and mechanisms of refractive error control. (12064076)
2002
43
Volume estimation of excimer laser tissue ablation for correction of spherical myopia and hyperopia. (11980859)
2002
44
Effect of peripapillary chorioretinal atrophy on GDx parametersin patients with degenerative myopia. (12427231)
2002
45
Intraocular lens implantation and laser in situ keratomileusis (bioptics) to correct high myopia and hyperopia with astigmatism. (11316030)
2001
46
Laser in situ keratomileusis for myopia and hyperopia using the Lasersight 200 laser in 300 consecutive eyes. (11110312)
2000
47
Clinical features and surgery for acquired progressive esotropia associated with severe myopia. (10071152)
1999
48
A second locus for familial high myopia maps to chromosome 12q. (9792869)
1998
49
Prolidase deficiency associated with pathologic myopia. (9587929)
1998
50
Flicker parameters are different for suppression of myopia and hyperopia. (9373666)
1997

Variations for Myopia

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Expression for genes affiliated with Myopia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myopia

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Pathways for genes affiliated with Myopia

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Compounds for genes affiliated with Myopia

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GO Terms for genes affiliated with Myopia

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16Gene Ontology
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Biological processes related to Myopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to stimulusGO:0508969.9CLDN19, NYX

Products for genes affiliated with Myopia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myopia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet