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MCID: MYP006

Myopia malady
165 genes, 4 tissues, 541 related diseases, 22 phenotypes, 117 articles, clinical trials.

Summaries for Myopia

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MalaCards: Myopia, also known as myopia (disorder), is related to myopia-2 and myopia 15. An important gene associated with Myopia is NYX (nyctalopin), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Metalloproteases in connective tissue degradation. The compounds glycosaminoglycan and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include retina, t cells and b cells, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Descriptions for Myopia

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6Disease Ontology, 7diseasecard, 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM
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Aliases & Descriptions:

myopia 6 7 43
myopia (disorder) 6
near-sightedness 6
near vision 6

External Ids:

ICD9CM19 367.1

Related Diseases for Myopia

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13GeneCards, 14GeneDecks
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Disease types for myopia family:

myopia 6 myopia-2
myopia 8 myopia 7
myopia 17 myopia 12
myopia 13 myopia 15
myopia 10 myopia-1
myopia 9 myopia-3
myopia 5 myopia 16
myopia 11

Diseases related to myopia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 523)
idRelated DiseaseScoreTop Affiliating Genes
1myopia-231.4LPIN2, MYOM1, MYP2, CLUL1, DLGAP1, TGIF1
2myopia 1531.3MYP15, GOLGA8B, GJD2, ACTC1
3myopia 1131.1MYP11, BLID, MIR100HG
4pierre robin sequence28.3COL11A2, COL9A2, COL11A1, COL2A1, COL9A1
5hyperopia28.3CFP, MSX2, MFRP, MATK, IFITM2, TUSC5
6marshall syndrome28.2COL11A2, COL11A1, COL2A1
7lens subluxation28.2LEPREL1, FBN1, CBS, GALT
8night blindness28.2GRK1, GRM6, GPR34, TRPM1, NYX, RP2
9congenital stationary night blindness28.2GRK1, GRM6, GPR34, TRPM1, NYX, SLC24A1
10ectopia lentis28.0FBN1, CBS, ADAMTS10, ADAMTS17
11microphthalmia27.7BFSP2, PAX6, FOS, MFRP, EYA1, GJA8
12chorioretinitis27.6SERPINF1, VCAN, CLDN19, PAX6, IGF2, COL11A1
13chorioretinal atrophy27.6SERPINF1, VCAN, IGF2, COL11A1, COL2A1, TGFA
14coloboma26.8PAX6, ZEB2, GJA8, CRYBB1, SOD1, SOX2
15refractive error26.7ZNF644, VIP, MMP1, MMP2, MMP3, MMP9
16hirschsprung's disease26.5GCG, VIP, ZEB2, LAMA1, NOS1, EDN1
17short stature24.8VPS13B, VDR, CD36, MMP9, FBN1, IGF2
18cataract24.1SERPINF1, VEGFA, VCAN, MYOC, BFSP2, PAX6
19age related macular degeneration23.1RDH8, SERPINF1, VEGFA, CLUL1, CFP, CD36
20twinning23.0GCG, VEGFA, VDR, MYP8, MYP7, MYP10
21macular degeneration23.0CNGB3, RDH8, SERPINF1, VEGFA, CLUL1, LAMB2
22conjunctivitis22.1GCG, VEGFA, VDR, CD36, MMP9, FOS
23choroiditis21.3SERPINF1, VIP, VEGFA, RARB, PAX6, LAMB2
24glaucoma20.4SERPINF1, VEGFA, MYOC, PAX6, BDNF, LAMA3
25blindness19.5CNGB3, GCG, SERPINF1, VIP, VEGFA, VDR
26retinitis18.5ZNF644, CNGB3, RDH8, SERPINF1, VIP, VEGFA
27myopia 617.1ZNF644, CNGB3, RDH8, VPS13B, GCG, GC
28blue cone monochromacy14.1CNGB3, TEX28, TEX28P2, NYX, OPN1LW, OPN1MW
29vitreoretinal degeneration14.1LEPREL1, COL9A2, COL18A1, COL11A1, COL2A1, ADAMTS18
30red-green color vision defects14.1TEX28, OPN1LW, OPN1MW, OPN1MW2
31nystagmus14.0CLDN19, PAX6, LAMB2, GRK1, TRPM1, NYX
32stickler syndrome14.0COL11A2, COL9A2, COL11A1, COL2A1, COL9A1
33color blindness14.0CNGB3, TEX28, TEX28P2, OPN1LW, OPN1MW, OPN1MW2
34cone dystrophy14.0CNGB3, SERPINF1, RPGR, PRPH2, OPN1LW, OPN1MW
35macroglossia14.0COL11A2, COL11A1, COL2A1, COL9A1
36rhyns syndrome14.0RP2, RPGR, TIMP3, PRPH2, PRPH, OPN1MW
37wagner syndrome14.0VCAN, COL11A2, COL11A1, COL2A1
38anisometropia13.9IFITM2, EARS2, DSE, DPT
39peters anomaly13.9MYOC, PAX6, GJA8, CRYBB1, TGFB2
40branchiootorenal spectrum disorders13.9EYA1, SIX1, SIX5
41neuronitis13.9CNGB3, GCG, SERPINF1, VIP, VIPR2, VEGFA
42cycloplegia13.9IFITM2, DSE, DPT
43branchiootorenal syndrome13.8EYA1, SIX1, SIX5
44corneal dystrophy13.8MYOC, PAX6, TGFB1, TGIF1, DCN, LUM
45achromatopsia13.8CNGB3, TEX28, TEX28P2, NYX
46retinal degeneration13.8RDH8, SERPINF1, PAX6, BDNF, FGF2, MFRP
47sensorineural hearing loss13.8BDNF, COL11A2, COL11A1, COL2A1, SOX2
48astigmatism13.7SERINC1, FLNA, GREM2, MATK, IFITM2, TUSC5
49pseudoachondroplasia13.6CD36, FMOD, COL9A2, COL9A1, DCN
50epiphyseal dysplasia13.6CD36, COL11A2, COL9A2, COL11A1, COL2A1, COL9A1

Graphical network of the top 20 diseases related to myopia:



Graphical network of diseases related to myopia

Clinical Features for Myopia

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Drugs & Therapeutics for Myopia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Myopia

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Anatomical Context for Myopia

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22MalaCards
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MalaCards organs/tissues related to myopia:

22
Retina, T cells, B cells, Endothelial

Phenotypes for genes affiliated with Myopia

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25MGI
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MGI Mouse Phenotypes related to myopia:

25 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.6SIX5, SIX1, GJD2, EYA1, MSX2, RASGRF1
2renal/urinary system phenotypeMP:00053679.9COL18A1, COL2A1, TGFB2, DCN, SIX1, EYA1
3respiratory system phenotypeMP:00053889.8SIX1, COL2A1, NOS1, DAND5, EYA1, CBS
4craniofacial phenotypeMP:00053829.5COL11A1, COL2A1, EDN1, TGIF1, POMGNT1, SIX1
5integument phenotypeMP:00107719.1PLOD1, COL1A1, EGR1, DSE, TGFA, DPT
6hematopoietic system phenotypeMP:00053978.8HLA-DQB1, COL1A1, EIF2AK2, PRPH2, SIX1, LUM
7immune system phenotypeMP:00053878.7COL11A1, COL1A1, NOS1, CTSC, HLA-DQB1, COL2A1
8limbs/digits/tail phenotypeMP:00053718.4COL1A1, COL11A1, COL2A1, COL9A1, EIF2AK3, DSE
9growth/size phenotypeMP:00053787.7TIMP3, ACTC1, EIF2AK3, EGR1, COL2A1, COL1A1
10behavior/neurological phenotypeMP:00053867.7COL1A1, NOS1, PLOD1, CTSC, CTNND2, HLA-DQB1
11hearing/vestibular/ear phenotypeMP:00053777.4COL1A1, COL11A1, COL2A1, COL9A1, EDN1, TGFB2
12reproductive system phenotypeMP:00053897.4CBS, EYA1, PDLIM5, TIMP1, TIMP3, DSE
13normal phenotypeMP:00028737.3EYA1, IGF1, MATK, FGF2, FLNA, HLA-DQB1
14skeleton phenotypeMP:00053906.7COL2A1, COL11A2, NOS1, EYA1, IGF1, COL9A1
15mortality/agingMP:00107686.1EDN1, PDLIM5, COL2A1, COL11A1, NOS1, PLOD1
16nervous system phenotypeMP:00036316.0CNGB3, MSX2, CD36, MMP2, FOS, FLNA
17digestive/alimentary phenotypeMP:00053815.7EDN1, COL2A1, COL11A1, COL1A1, NOS1, HLA-DQB1
18muscle phenotypeMP:00053694.9TGFB1, TGFA, TIMP3, ACTC1, EDN1, PDLIM5
19vision/eye phenotypeMP:00053914.8RARA, FMOD, FLNA, FGF2, MFRP, MET
20cardiovascular system phenotypeMP:00053854.0ACTC1, EGR1, EDN1, PDLIM5, COL2A1, COL18A1
21cellular phenotypeMP:00053843.7ACTC1, EIF2AK3, EIF2AK2, EGR1, COL1A1, NOS1
22homeostasis/metabolism phenotypeMP:00053762.5TTR, ACTC1, EIF2AK3, EGR1, EDN1, COL9A1

Publications for genes affiliated with Myopia

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35PubMed
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Articles related to myopia:

(show top 50)    (show all 117)
idTitleAuthorsYearAffiliating Genes
1Congenital ocular malformations (lens subluxation, pu pillary displacement, cataract, myopia) and classic galactosaemia associated wi th Q188R anda88/or G1391A mutations. (20222886)Schmidt D.... Tacke U.2011GALT
2Vitamin D receptor (VDR) and group-specific component (GC, vitamin D-binding protein) polymorphisms in myopia. (21357399)Mutti D.O.... Zadnik K.2011VDR, GC
3IGF-1 gene polymorphisms in Polish families with high -grade myopia. (21976954)Rydzanicz M.... Gajecka M.2011IGF1
4A functional polymorphism at 3'UTR of the PAX6 gene m ay confer risk for extreme myopia in the Chinese. (21421876)Liang C.L.... Juo S.H.2011PAX6
5Systematic investigation of the relationship between high myopia and polymorphisms of the MMP2, TIMP2, and TIMP3 genes by a DNA pool ing approach. (21421877)Leung K.H.... Yip S.P.2011MMP2, TIMP2, TIMP3
6Correlation of misfolded transthyretin in abnormal vi treous and high myopia related ocular pathologies. (21821015)Shao J.... Yao Y.2011TTR
7Replication study supports CTNND2 as a susceptibility gene for high myopia. (21911587)Lu B.... Zhang Q.2011CTNND2
8PAX6 haplotypes are associated with high myopia in Ha n chinese. (21589860)Jiang B.... Yip S.P.2011PAX6
9High myopia caused by a mutation in LEPREL1, encoding prolyl 3- hydroxylase 2. (21885030)Mordechai S.... Birk O.S.2011LEPREL1
10Exome sequencing identifies ZNF644 mutations in high myopia. (21695231)Shi Y.... Yang Z.2011ZNF644
11A genome-wide association study for myopia and refrac tive error identifies a susceptibility locus at 15q25. (20835236)Hysi P.G.... Hammond C.J.2010RASGRF1
12Investigation of the association between all-trans-re tinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese. (21043051)Yu Y.S.... Han W.2010RDH8
13Association analysis of retinoic acid receptor beta ( RARbeta) gene with high myopia in Chinese subjects. (20508731)Ding Y.... Zhou X.2010RARB
14Association of the lumican gene functional 3'-UTR pol ymorphism with high myopia. (19643966)Lin H.J.... Tsai F.J.2010LUM
15Myocilin polymorphisms and high myopia in subjects of European origin. (19180258)Zayats T.... Guggenheim J.A.2009MYOC
16Myopia and polymorphisms in genes for matrix metalloproteinases. (19279308)Hall N.F.... Martyn C.N.2009MMP3, MMP9, MMP1
17TGFB1 as a susceptibility gene for high myopia: a replication study with new findings. (19365037)Zha Y.... Yip S.P.2009TGFB1
18Common variant in myocilin gene is associated with high myopia in isolated population of Korcula Island, Croatia. (19260140)Vatavuk Z.... Zgaga L.2009COL1A1, MYOC
19A novel genetic variant of BMP2K contributes to high myopia. (19927351)Liu H.P.... Tsai F.J.2009BMP2K
20Homozygous mutations in ADAMTS10 and ADAMTS17 cause l enticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. (19836009)Morales J.... Al Tassan N.2009ADAMTS10, ADAMTS17
21Hepatocyte growth factor and myopia: genetic association analyses in a caucasian population. (19471602)Yanovitch T.... Young T.L.2009MET, HGF
22An evaluation of OPTC and EPYC as candidate genes for high myopia. (19844586)Wang P.... Zhang Q.2009OPTC, EPYC
23The retinoic acid receptor alpha (RARA) gene is not a ssociated with myopia, hypermetropia, and ocular biometric measures. (19626135)Veerappan S.... Baird P.N.2009RARA
24Evaluation of EGR1 as a candidate gene for high myopia. (18636116)Li T.... Zhang Q.2008EGR1
25Absence of Association between COL1A1 Polymorphisms and High Myopia in the Japanese Population. (18836165)Nakanishi H.... Yoshimura N.2008COL1A1
26Refinement of the MYP3 locus on human chromosome 12 in a German family with Mendelian autosomal dominant high-grade myopia by SNP array mapping. (18360688)Nurnberg G.... Pusch C.M.2008MYP3
27A PAX6 gene polymorphism is associated with genetic predisposition to extreme myopia. (17948041)Tsai Y.Y.... Tsai F.J.2008PAX6
28Effects of intravitreally and intraperitoneally injec ted atropine on two types of experimental myopia in chicken. (17101130)Diether S.... Trendelenburg A.U.2007PDLIM5
29The Roles of PAX6 and SOX2 in Myopia: lessons from the 1958 British Birth Cohort. (17898260)Simpson C.L.... Rahi J.S.2007PAX6, SOX2
30Candidate gene and locus analysis of myopia. (17653045)Mutti D.O.... Zadnik K.2007FGF2, BDNF, COL18A1
31Genetic mapping of myopia susceptibility loci. (17962440)SchAoche M.... Baird P.N.2007MYP15
32Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population. (17438518)Tang W.C.... Yap M.K.2007MYOC
33Basic fibroblast growth factor suppresses retinal neuronal apoptosis in form-deprivation myopia in chicks. (17114124)Mao J.... Fu C.2006NUDT6
34Evaluation of MMP3 and TIMP1 as candidate genes for high myopia in young Taiwanese men. (16935611)Liang C.L.... Juo S.H.2006MMP3, TIMP1
35Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes. (15723005)Scavello G.S.... Young T.L.2005DLGAP1, TGIF1, LPIN2
36Fundamentals of modern treatment of myopia (16519089)Czepita D.2005FGF2
37Retinal serotonin, eye growth and myopia development in chick. (15949800)George A.... Pow D.V.2005PDLIM5
38X-linked high myopia associated with cone dysfunction. (15197065)Young T.L.... King R.A.2004MYP1
39Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia. (15223781)Scavello G.S.... Young T.L.2004TGIF1, MYP2
40Variations of the zinc finger protein 161 gene in Chinese with or without high myopia (15639979)Wang G.B.... Guo X.M.2004ZFP161
41A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins. (15307048)Hammond C.J.... Spector T.D.2004PAX6, MYP7, MYP10
42Variation of the peripherin gene in Chinese with or without high myopia (16135441)Li J.... Guo X.M.2002PRPH, PRPH2
43A study on the prevention and treatment of myopia wit h nacre on chicks. (11428903)Xu H.... Han X.2001NOS1
44Evaluation of selected parameters of collagen metabolism in patients with myopia (11126178)Nowak M.... Buntner B.2000CD36
45Evidence that a locus for familial high myopia maps to chromosome 18p. (9634508)Young T.L.... King R.A.1998MYP2
46A second locus for familial high myopia maps to chromosome 12q. (9792869)Young T.L.... King R.A.1998MYP3
47Prolidase deficiency associated with pathologic myopia. (9587929)Kiratli H.... Satilmis M.1998PEPD
48Developmental mechanism of low myopia and therapeuti c possibilities. A review (10025113)Tokoro T.1998EDN1
49A preliminary study on the association between HLA-DPB1 gene and pathological myopia (10680551)Zhang K.... Chu R.1997HLA-DPB1
50Stimulation of dopaminergic amacrine cells by stroboscopic illumination or fibroblast growth factor (bFGF, FGF-2) injections: possible roles in prevention of form-deprivation myopia in the chick. (7583283)Rohrer B.... Stell W.K.1995FOS, NUDT6

Expression for genes affiliated with Myopia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Myopia

Pathways for genes affiliated with Myopia

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36QIAGEN, 10EMD Millipore, 20KEGG, 41Thomson Reuters, 3Cell Signaling Technology
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Pathways related to myopia according to GeneDecks:

(show top 50)    (show all 83)
idPathwayScoreTop Affiliating Genes
1Actin-Based Motility by Rho Family GTPases369.8BDNF, FGF13, IGF1
2Metalloproteases in connective tissue degradation109.7MMP1, LAMA1, LAMA3, MMP2, MMP3, MMP9
3Focal adhesion209.6COL1A1, HGF, COL11A1, COL11A2, MET, FLNA
4Glioma Invasiveness369.5TIMP3, TIMP1, BDNF, FGF13, TGFB2, FGF2
5PTEN Pathway369.5COL18A1, BDNF, COL9A1, TIMP3, NUDT6, HGF
6CREB Pathway369.4IGF1, NUDT6, TGFB2, TIMP3, BDNF, IGF2
7PPAR Pathway369.4FGF2, FGF13, NUDT6, TGFB2, TIMP2, MET
8UPA-UPAR Pathway369.3LAMA1, MMP9, LAMA3, LAMB2, MMP2, MMP3
9ERK Signaling369.0COL11A2, TGFA, TGFB2, COL1A1, COL9A2, COL18A1
10Ras Pathway369.0AXL, NUDT6, FOS, FGF13, FGF2, MET
1114-3-3 Induced Intracellular Signaling368.9TIMP3, TIMP1, BDNF, NUDT6, TGFB1, TGFB2
12ERK5 Signaling368.8NUDT6, BDNF, FOS, FGF13, MET, TIMP3
13Paxillin Interactions368.7TGFB2, AXL, FGF13, FGF2, NUDT6, TGFA
14Inhibition of Angiogenesis by TSP1368.7TGFB2, LAMA1, LAMA3, LAMB2, CD36, MMP9
15eNOS Signaling368.7TGFB1, NUDT6, AXL, TGFA, BDNF, TGFB2
16Cell adhesion ECM remodeling108.6LAMA3, TIMP3, TIMP2, MMP1, MMP2, MMP3
17Cell adhesion_ECM remodeling418.6VCAN, LAMA1, MMP1, LAMA3, COL2A1, TIMP1
18Angiogenesis38.4MMP2, TIMP1, FGF2, MMP9, TIMP2, TIMP3
19eIF2 Pathway368.4EIF2AK3, IGF2, MET, TIMP3, IGF1, FGF2
20mTOR Pathway368.2FGF2, BDNF, NUDT6, TGFB2, TGFB1, TGFA
21DHA Signaling368.2TIMP2, HGF, TGFB2, TGFB1, TGFA, TIMP3
22Apoptotic Pathways in Synovial Fibroblasts368.2FGF2, TIMP2, TIMP1, IGF1, NUDT6, IGF2
23p53 Mediated Apoptosis368.1FGF13, FGF2, MET, IGF1, TIMP1, TIMP3
24Telomerase Components in Cell Signaling368.1FGF13, FGF2, MET, IGF2, NUDT6, IGF1
25Mitochondrial Apoptosis368.1TGFA, NUDT6, HGF, TGFB1, TIMP3, TIMP2
26NF-KappaB (p50-p65) Pathway368.1IGF1, IGF2, MET, FGF2, TIMP2, BDNF
27NF-KappaB Family Pathway368.1HGF, IGF1, IGF2, TIMP1, FGF2, NUDT6
28Cellular Apoptosis Pathway368.1NUDT6, TGFB2, TGFB1, TGFA, TIMP3, TIMP2
29Nanog in Mammalian ESC Pluripotency368.1TGFB2, NUDT6, FGF2, SOX2, HGF, TGFB1
30Nuclear Receptor Activation by Vitamin-A368.0IGF2, FGF13, HGF, TIMP3, TGFA, TGFB1
31Rac1 Pathway368.0TGFB2, HGF, NUDT6, TGFB1, TGFA, TIMP3
32p70S6K Signaling367.9TIMP1, TIMP3, TGFA, TGFB1, NUDT6, HGF
33IP3 Pathway367.9NUDT6, BDNF, FGF13, IGF2, FGF2, MET
34GSK3 Signaling367.8IGF1, TGFB2, AXL, BDNF, NUDT6, HGF
35Activation of PKC through GPCR367.8BDNF, HGF, NUDT6, TGFB2, TGFB1, TGFA
36Phospholipase-C Pathway367.8BDNF, LAMA1, LAMA3, LAMB2, FGF13, FGF2
37Molecular Mechanisms of Cancer367.8NUDT6, FGF2, RARB, BDNF, LAMA1, LAMB2
38Renin-Angiotensin Pathway367.8MET, BDNF, FGF2, IGF1, FOS, FGF13
39TGF-Beta Pathway367.8TIMP1, HGF, NUDT6, TGFB2, BDNF, FOS
40Intracellular Calcium Signaling367.7TGFB2, NUDT6, HGF, TIMP2, IGF2, TGFB1
41Estrogen Pathway367.7TIMP2, FOS, HGF, NUDT6, AXL, BDNF
42GPCR Pathway367.7TIMP2, TIMP3, NUDT6, TGFB2, TIMP1, IGF1
43Pathways in cancer207.6TGFA, FGF2, FGF13, FOS, LAMB2, MMP2
44Activation of PKA through GPCR367.6IGF2, IGF1, TIMP1, TIMP2, TGFB2, TIMP3
45Rho Family GTPases367.4HGF, NUDT6, TGFB2, TGFB1, TGFA, TIMP3
46MAPK Signaling367.4COL9A1, COL11A2, COL1A1, COL9A2, COL18A1, HGF
47NFAT in Immune Response367.4TGFB2, NUDT6, TGFA, HGF, BDNF, TIMP1
48ILK Signaling367.3IGF2, IGF1, COL11A2, COL1A1, COL9A2, BDNF
49Pancreatic Adenocarcinoma367.2TGFA, TGFB1, BDNF, TGFB2, TIMP3, TIMP2
50JAK-STAT Pathway367.1TGFA, TIMP2, TIMP1, TIMP3, TGFB1, TGFB2

Compounds for genes affiliated with Myopia

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32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB
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Compounds related to myopia according to GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1glycosaminoglycan32 9.9VCAN, CD36, FMOD, FGF2, MET, COL1A1
2hyaluronic acid32 18 10.4VCAN, MYOC, CD36, MMP1, MMP3, FMOD
3egcg32 9.4TIMP1, TIMP2, TGFB2, SOD1
4estradiol32 9 18 9 12.3GC, RARB, BDNF, TIMP2, TIMP3, TGFB2
5agar32 9.2RARA, RARB, FGF2, MET, IGF2, CTNND2
6vitamin a32 9 18 9 11.8RDH8, GC, VDR, RARA, RARB, GRK1
7heparin32 9 18 9 11.7GCG, SERPINF1, VCAN, LAMA1, LAMB2, CFP
8(4-aminophenyl)mercuric acetate32 8.7CD36, MMP1, MMP2, MMP3, MMP9, TIMP1
9tgf beta132 8.6VCAN, RARA, CD36, MMP1, MMP2, MMP3
10aspartate32 8.6GC, VIP, VDR, RARA, BDNF, SCT
11calcitriol32 42 9 18 9 12.5GC, VDR, RARA, RARB, CD36, FOS
1212-o-tetradecanoylphorbol 13-acetate32 8.5RARA, RARB, MMP2, MMP3, MMP9, FOS
13hydroxyproline32 18 9.5CD36, MMP1, MMP2, MMP9, FBN1, COL1A1
14alginate32 8.5VCAN, CD36, MMP2, MMP3, FGF2, IGF1
15procollagen32 8.4CFP, CD36, MMP1, MMP2, MMP3, MMP9
16ascorbic acid32 18 9.3VDR, MYOC, BDNF, LEPREL1, CFP, CD36
17batimastat32 42 9 9 11.3CD36, MMP1, MMP2, MMP3, MMP9, TIMP1
18ly29400232 8.2GCG, VEGFA, RARA, MMP2, MMP9, FOS
19oligonucleotide32 8.0VCAN, RARA, RARB, SCT, MSX2, MMP1
20cysteine32 8.0GCG, SERPINF1, VDR, MYOC, RARA, RARB
21paraffin32 7.8VEGFA, CD36, MMP2, FGF2, MET, IGF2
22glutamate32 7.6GCG, GC, SERPINF1, VIP, VDR, CHRM1
23zinc32 18 8.5RARA, RARB, ZFP161, BDNF, ZEB2, SCT
24ribonucleic acid32 7.5RARA, RARB, MMP1, MMP2, MMP3, MMP9
25vitamin d32 7.4GC, VDR, RARA, RARB, CD36, MMP3
26cytochalasin d32 42 8.4CD36, MMP1, MMP2, MMP3, MMP9, FOS
27adenylate32 7.2GCG, GC, VIP, VIPR2, VDR, RARB
28norepinephrine32 9 18 9 10.1GCG, VIP, BDNF, SCT, MMP1, MMP2
29calcium32 9 18 9 10.0CNGB3, SERPINF1, VIP, RARA, RASGRF1, CLDN19
30thymidine32 18 8.0VIP, VDR, RARA, RARB, BDNF, SCT
31creatinine32 7.0GCG, GC, VDR, BDNF, MMP1, MMP2
32cyclosporin a32 42 7.9VIP, VDR, SCT, MMP1, MMP3, MMP9
33testosterone32 9 18 9 9.9GC, VIP, VDR, RARA, RARB, BDNF
34matrigel32 6.8SERPINF1, VEGFA, BDNF, CD36, MMP1, MMP2
35arginine32 6.8GCG, VIP, VDR, MYOC, RARA, RARB
36indomethacin32 9 9 8.7GCG, VIP, BDNF, SCT, MMP1, MMP3
37glutamine32 6.6GCG, VIP, VDR, SCT, CD36, MMP3
38pd 98,05932 6.4GCG, RARA, BDNF, SCT, MMP1, MMP2
39alanine32 6.2GCG, VIP, VDR, MYOC, RARA, PAX6
40actinomycin d32 5.8VEGFA, VDR, RARA, RARB, BDNF, MMP9
41dexamethasone32 42 34 9 9 9.8SERPINF1, VIP, VEGFA, VDR, MYOC, RARA
42sb 20358032 42 6.7GCG, VEGFA, VDR, CD36, MMP1, MMP2
43genistein32 9 18 9 8.5GCG, VEGFA, VDR, RARB, CHRM1, CD36
44tyrosine32 5.5SERPINF1, VIP, VEGFA, RARA, RASGRF1, RARB
45pge232 5.4VIP, VEGFA, VDR, RARB, SCT, CD36
46retinoic acid32 42 18 7.1GC, SERPINF1, VDR, RARA, RARB, PAX6
47serine32 4.8GCG, GC, SERPINF1, VIP, VDR, RARA
48vegf32 4.5GCG, SERPINF1, VIP, VEGFA, VCAN, RARA
49estrogen32 4.4GCG, GC, VIP, VEGFA, VDR, RARA
50cycloheximide32 4.4GCG, VEGFA, VDR, MYOC, RARA, RARB

GO Terms for genes affiliated with Myopia

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Sources:
12Gene Ontology
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Cellular components related to myopia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00578810.3COL9A1, COL2A1, COL11A1, COL18A1, COL9A2, COL1A1
2Golgi lumenGO:00579610.1VCAN, FMOD, TGFB1, DCN, PRELP, LUM
3lysosomal lumenGO:04320210.0LUM, PRELP, DCN, FMOD, VCAN, GC
4basement membraneGO:0056049.7TGFB2, TIMP3, TIMP2, TIMP1, COL2A1, FBN1
5extracellular matrixGO:0310129.4TGFB2, DPT, DCN, PRELP, SOD1, LUM
6platelet alpha granule lumenGO:0310938.6HGF, TGFB2, TGFB1, TIMP1, IGF1, VEGFA
7proteinaceous extracellular matrixGO:0055788.3TGFB1, DPT, PRELP, OPTC, LUM, ADAMTS17
8extracellular spaceGO:0056155.6EDN1, COL2A1, COL18A1, COL1A1, IGF1, IGF2
9extracellular regionGO:0055764.7HGF, EDN1, COL9A1, COL2A1, COL11A1, COL18A1

Biological processes related to myopia according to GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.7LUM, RPGR, COL1A1, COL18A1, COL11A1, COL2A1
2collagen fibril organizationGO:03019910.7LUM, DPT, TGFB2, COL2A1, COL11A1, COL1A1
3cartilage development involved in endochondral bone morphogenesisGO:06035110.5COL2A1, COL1A1, CBS
4frontal suture morphogenesisGO:06036410.0MSX2, TGFB1, TGFB2
5myoblast proliferationGO:0514509.9MET, IGF1, HGF
6cellular response to growth factor stimulusGO:0713639.8MSX2, MET, COL1A1, TGFB1, TGIF1
7collagen catabolic processGO:0305749.7PEPD, MMP9, MMP3, MMP2, MMP1
8agingGO:0075689.6DCN, TGFB2, TGFB1, TIMP3, TIMP1, VDR
9inner ear developmentGO:0488399.5SIX1, SOX2, TGFB2, TGFB1, IGF1, BDNF
10extracellular matrix disassemblyGO:0226179.4TIMP2, TIMP1, MMP9, MMP3, MMP2, MMP1
11extracellular matrix organizationGO:0301989.4COL18A1, COL11A1, COL2A1, COL9A1, TIMP1, TIMP2
12skeletal system developmentGO:0015019.4PRELP, EIF2AK3, COL2A1, COL9A2, COL1A1, COL11A2
13negative regulation of cell proliferationGO:0082859.3TIMP2, TGFB1, TGFB2, TGIF1, DPT, SIX5
14sensory perception of soundGO:0076059.3SIX1, SOD1, COL2A1, COL11A1, COL1A1, COL11A2
15positive regulation of mitosisGO:0458409.1TGFA, EDN1, IGF1, IGF2, MET
16positive regulation of cell divisionGO:0517819.1TGFB2, TGFB1, TGFA, IGF2, FGF2, VEGFA
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.1EYA1, NOS1, EGR1, TGFB1, SOX2, SIX1
18positive regulation of cell proliferationGO:0082847.7IGF1, EDN1, TIMP1, TGFB1, TGFB2, IGF2
19response to drugGO:0424937.7SOD1, TGIF1, TGFB2, TGFB1, TGFA, ACTC1
20platelet degranulationGO:0025767.4HGF, SOD1, TGFB2, TGFB1, TIMP1, IGF1
21platelet activationGO:0301687.3HGF, SOD1, TGFB2, TGFB1, TIMP1, COL1A1

Molecular functions related to myopia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:03002010.5COL9A1, COL2A1, COL9A2, COL11A2
2extracellular matrix structural constituentGO:00520110.4LUM, OPTC, PRELP, COL11A1, COL1A1, FBN1
3sequence-specific DNA bindingGO:0435659.4SIX1, SOX2, PRDM5, TGIF1, EGR1, IRX2
4metalloendopeptidase activityGO:0042229.0ADAMTS18, ADAMTS17, ADAMTS10, MIPEP, MMP9, MMP3
5hormone activityGO:0051798.7TTR, EDN1, IGF1, IGF2, SCT, VIP
6growth factor activityGO:0080838.0VEGFA, HGF, NUDT6, TGFB2, TGFB1, TGFA

Sources for Myopia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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