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Myositis malady
13 drugs, 161 genes, 9 tissues, 946 related diseases, 25 phenotypes, 159 articles, clinical trials.

Summaries for Myositis

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23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Myositis is inflammation of your skeletal muscles, which are also called the voluntary muscles. these are the muscles you consciously control that help you move your body. an injury, infection or autoimmune disease can cause myositis. the diseases dermatomyositis and polymyositis both involve myositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. both diseases are usually treated with prednisone, a steroid medicine, and sometimes other medicines.23

MalaCards: Myositis, also known as inflammatory disorder of muscle (disorder), is related to inclusion body myositis and myositis ossificans. An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Cell adhesion molecules (CAMs) and RAR-Gamma-RXR-Alpha Degradation. The drugs chlorzoxazone and chlorphenesin carbamate and the compounds sp 600125 and lysine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and skeletal muscle, and related mouse phenotypes are respiratory system and integument.

Wikipedia: Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely...44 more...

Aliases & Descriptions for Myositis

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6Disease Ontology, 17Genetics Home Reference, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 24MeSH, 40SNOMED-CT, 27NCIt, 33OMIM
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Aliases & Descriptions:

myositis 6 17 8 32 23 43
inflammatory disorder of muscle (disorder) 6
myositis unspecified (disorder) 6
inflammatory disorder 43
myositis (disorder) 6
myositis nos 6

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SNOMED-CT40 203110007, 268108002, 26889001 128496001, more

Related Diseases for Myositis

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13GeneCards, 14GeneDecks
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Diseases related to myositis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 943)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis38.2VCAM1, CD80, MME, APP, MAPT, ICAM1
2myositis ossificans32.9BMP1, USP6, JUN, FOS, FMR1, HSPA9
3muscular dystrophy32.2PIK3C2A, NCAM1, LMNA, MYOD1, UTRN, CKM
4myofibrillar myopathy29.9CRYAB, RPS27A, DES
5calpainopathy29.8LMNA, CAPN3, DYSF, DMD, TTN
6oculopharyngeal muscular dystrophy29.7MYOD1, BCL2, APP, PYGM, RPS27A, TGM2
7becker muscular dystrophy29.6PIK3C2A, NCAM1, UTRN, LAMA2, DYSF, DMD
8alzheimer's disease28.9CLU, APOE, APP, MAPT, TTR, PSEN1
9tauopathy28.9PARK7, PARK2, CDK5, APP, MAPT, SNCA
10polymyositis28.8PIK3C2A, NCAM1, SERPINA3, VCAM1, MYBPC1, UTRN
11muscle disorders28.6CHKA, CHKB, MAPT, TTN, PRG2, RYR1
12inclusion body myopathy28.5NCAM1, VCP, MME, APP, DMD, SNCA
13idiopathic myopathy28.4NARS, CHKB, IL1A, HLA-B, TRIM21, TGM2
14adult dermatomyositis28.1PIK3C2A, VCAM1, CHKB, INS, ICAM1
15b-cell lymphomas27.8CLU, BCL2, BCL2L1, CIITA, BAX, CD80
16behcet's disease27.4IL8, IFNA1, HLA-A, HLA-B, HLA-C, TNFRSF1B
17graft versus host disease27.4CD28, GZMB, IL1RAPL2, IL2, IFNG, HLA-A
18muscular atrophy27.1NCAM1, LMNA, UTRN, BCL2, BCL2L1, CHKB
19rheumatoid arthritis27.0IL1RN, HLA-DRB1, TNFRSF1A, CRP, TARS
20celiac disease26.8CIITA, IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1
21arthritis26.7IL17A, IL1A, IL1B, IL6, IL8, TNFRSF1A
22dermatomyositis26.7PIK3C2A, SERPINA3, VCAM1, MYBPC1, UTRN, CHKA
23familial mediterranean fever26.5GSN, IL1B, IL1RAPL2, IL1RN, IL6, IL8
24chronic infantile neurological cutaneous articular syndrome26.4IL1B, IL1RAPL2, IL1RN, CASP1, TNFRSF1A, CRP
25neuromyelitis optica25.9MMP9, IL6, HLA-A, HLA-B, HLA-C, HLA-DQA1
26antiphospholipid syndrome25.8VCAM1, LDLR, MMP2, MMP9, HLA-DQA1, HLA-DQB1
27pelvic inflammatory disease25.8MMP2, MMP9, IFNG, HLA-DQA1, HLA-DQB1, CRP
28thymoma25.7PIK3C2A, VIM, BCL2, CHKB, MMP2, MMP9
29renal cell carcinoma25.4VIM, CLU, PARK2, BCL2L1, CIITA, CHKA
30thrombocytosis25.3IL1A, IL1B, IL6, IFNA1, HMGCR, CRP
31myopathy25.0PIK3C2A, NCAM1, VIM, NARS, VCAM1, VCP
32amyloidosis25.0LRP1, SERPINA3, CLU, PARK2, BCL2, BACE1
33interstitial lung disease24.7PIK3C2A, NARS, CHKB, MMP7, MMP9, FOS
34fibromyalgia24.7CHKB, INS, IL1B, IL2, IL5, IL6
35crohn's disease24.3CD80, IL17A, IL1B, IL1RAPL2, IL1RN, IL6
36urticaria23.9VCAM1, MMP9, GZMB, INS, IL1A, IL1RAPL2
37allergic rhinitis22.8VCAM1, BCL2, CHKB, JUN, CD28, CD86
38rhinitis22.8VCAM1, BCL2, CHKB, JUN, CD28, CD86
39myasthenia gravis21.9NCAM1, UTRN, BCL2, CIITA, CHKB, CD28
40homocysteine21.8PIK3C2A, SERPINA3, VCAM1, CLU, LDLR, JUN
41osteoporosis21.5LMNA, JUN, CD36, MMP9, FOS, INS
42cholesterol20.1PIK3C2A, LRP1, SERPINA3, VLDLR, VIM, VCAM1
43sarcoidosis19.8PIK3C2A, SERPINA3, VIM, VCAM1, BCL2L1, KARS
44glomerulonephritis19.5LRP1, VIM, VCAM1, LMNA, CLU, BCL2
45sarcoma19.0PIK3C2A, NCAM1, SERPINA3, VIM, VCAM1, MYOD1
46vasculitis18.6LRP1, SERPINA3, VCAM1, CD28, CD36, CD86
47atherosclerosis18.3PIK3C2A, LRP1, VLDLR, VCAM1, LMNA, CLU
48obesity18.2PIK3C2A, LRP1, VCAM1, LMNA, CLU, PARK2
49asthma17.8LRP1, SERPINA3, VCAM1, LMNA, MYLK, BCL2
50leukemia15.9PIK3C2A, LRP1, NCAM1, SERPINA3, VIM, VCAM1

Graphical network of the top 20 diseases related to myositis:



Graphical network of diseases related to myositis

Clinical Features for Myositis

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Drugs & Therapeutics for Myositis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 carisoprodol, chlorphenesin, chlorphenesin carbamate, chlorzoxazone, cyclobenzaprine, cyclobenzaprine hydrochloride, metaxalone, methocarbamol, orphenadrine, orphenadrine citrate, orphenadrine hydrochloride, tizanidine, tizanidine hydrochloride

Genetic Tests for Myositis

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Anatomical Context for Myositis

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22MalaCards
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MalaCards organs/tissues related to myositis:

22
Bone marrow, Brain, Skeletal muscle, Kidney, Lung, Skin, Myeloid, T cells, B cells

Phenotypes for genes affiliated with Myositis

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25MGI
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MGI Mouse Phenotypes related to myositis:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.0MB, APOE, GSN, CDK5, PARK2, UTRN
2integument phenotypeMP:00107719.8TREX1, TRIM21, TNFRSF1A, TNFRSF1B, SNCA, HELLS
3endocrine/exocrine gland phenotypeMP:00053799.8PMS2, PSEN1, DMD, CAV1, IFNG, IL2
4other phenotypeMP:00053959.6TNFRSF1A, DMD, NOS2, SYT7, PSEN1, PRNP
5limbs/digits/tail phenotypeMP:00053719.4DMD, SP7, HELLS, THBS1, PSEN1, PRNP
6renal/urinary system phenotypeMP:00053679.0GAPDH, TREX1, CAV1, MAPT, APOE, INS
7normal phenotypeMP:00028738.8PTPRC, TNFSF13, HLA-DQB1, HMGCR, CAPN3, IFNG
8no phenotypic analysisMP:00030128.7HLA-C, DMD, SNCA, TGM2, TARDBP, PRNP
9hematopoietic system phenotypeMP:00053978.5DUSP4, DUSP1, TNFSF13, TRIM21, TREX1, HLA-DQB1
10liver/biliary system phenotypeMP:00053708.5IFNG, TREX1, DUSP1, PTPRC, DMD, SPTB
11reproductive system phenotypeMP:00053898.0SPTB, DMD, TNFRSF1A, CAV1, SNCA, NOS2
12adipose tissue phenotypeMP:00053757.9TNFRSF1B, DUSP1, DMD, SPTB, CRYAB, NOS2
13digestive/alimentary phenotypeMP:00053817.8CAV1, TREX1, PTPRC, DMD, SNCA, CRYAB
14skeleton phenotypeMP:00053907.4THBS1, TNFRSF1A, CAV1, IL6, IL17A, GSN
15muscle phenotypeMP:00053697.4GAA, GARS, EMD, NEB, RYR1, CST3
16immune system phenotypeMP:00053877.1ATG5, LRP1, CFB, LAMA2, LDLR, CIITA
17behavior/neurological phenotypeMP:00053866.3CAV1, CD47, CD86, CDK5, JUN, ATG5
18tumorigenesisMP:00020066.2PTPRC, TNFRSF1B, TNFRSF1A, CAV1, CASP1, ICAM1
19cardiovascular system phenotypeMP:00053854.8MMP9, UTRN, BMP1, MYOD1, MYLK, LMNA
20homeostasis/metabolism phenotypeMP:00053764.7APOA1, CD47, CD86, CD36, CDK5, CD28
21mortality/agingMP:0010768INFTREX1, APOE, APEX1, APBB1, FBL, IL6
22vision/eye phenotypeMP:0005391INFCRYAB, DMD, TNFRSF1B, TNFRSF1A, ICAM1, IFNG
23nervous system phenotypeMP:0003631INFINS, BACE2, UBB, LDLR, CHKB, BCL2L1
24growth/size phenotypeMP:0005378INF, GARS, SIRT1, NEB, RYR1, SQSTM1
25cellular phenotypeMP:0005384INFPMS2, SQSTM1, CXCR3, PRNP, PRF1, PSEN1

Publications for genes affiliated with Myositis

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35PubMed
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Articles related to myositis:

(show top 50)    (show all 159)
idTitleAuthorsYearAffiliating Genes
1Increased BACE1 mRNA and noncoding BACE1-antisense tr anscript in sporadic inclusion-body myositis muscle fibers--possibly caused by endoplasmic reticulum stress. (20236612)Nogalska A.... Askanas V.2010BACE1
2Cancer-associated myositis and anti-p155 autoantibody in a series of 85 patients with idiopathic inflammatory myopathy. (20075704)Trallero-AraguA!s E.... Vilardell-TarrAcs M.2010HLA-DQA1, HLA-DRB1
3CCR7+ myeloid dendritic cells together with CCR7+ T cells and CCR7+ macrophages invade CCL19+ nonnecrotic muscle fibers in inclusion body myositis. (19171354)Tateyama M.... Itoyama Y.2009CCL21, CCL19
4Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease? (19285864)Oflazer P.S.... Dincer P.2009CAPN3
5Acute kidney injury due to rhabdomyolysis-associated gangrenous myositis. (19260387)Daher E.F.... LibA^rio A.B.2008CHKB
6Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies. (18005224)Macaione V.... Rodolico C.2008TGM2
7In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized. (18601999)Terracciano C.... Askanas V.2008PARK7
8The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. (18270596)Delaunay A.... Ronai Z.2008RNF5
9Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of 'myositis ossificans-like lesions' are the early phases in the formation of soft-tissue aneurysmal bone cyst. (18265974)Sukov W.R.... Oliveira A.M.2008USP6
10Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. (18191026)Kannanayakal T.J.... Kuret J.2008MAPT, MYLK, RPS27A
11A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies. (17763410)Eloranta M.L.... Lundberg I.E.2007MX1
12Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population. (17606177)McClure D.L.... Hokanson J.E.2007CHKB
13Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis. (17572512)Salajegheh M.... Dalakas M.C.2007CD36, THBS1, CD47
14Raised troponin T in inclusion body myositis is common and serum levels are persistent over time. (16920359)Lindberg C.... Oldfors A.2006CHKB
15MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle. (17077152)Morosetti R.... Cossu G.2006MYOD1
16AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)Wojcik S.... Askanas V.2006APP, CRYAB
17In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. (16507114)Chinoy H.... Cooper R.G.2006HLA-DQA1, HLA-DQB1, HLA-DRB1
18CAPN3 mutations in patients with idiopathic eosinophilic myositis. (16607617)Krahn M.... Levy N.2006CAPN3
19Myositis-specific and myositis-associated antibodies in a series of eighty-eight Mediterranean patients with idiopathic inflammatory myopathy. (17013837)Selva-O'Callaghan A.... Vilardell-Tarres M.2006TRIM21
20Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)Sallum A.M.... Marie S.K.2006ICAM1, VCAM1
21Damage and inflammation in muscular dystrophy: potential implications and relationships with autoimmune myositis. (16224247)Tidball J.G.... Wehling-Henricks M.2005HLA-B
22Benign acute childhood myositis. (15973022)Rajajee S.... Rajarajan K.2005PIK3C2A
23Scleromyxedema with subclinical myositis. (17642556)Prasad P.V.... Viswanathan P.2004PIK3C2A
24Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. (15452314)Fratta P.... Askanas V.2004UBB
25Pathogenesis of myositis and myasthenia associated with titin and ryanodine receptor antibodies. (14592894)Skeie G.O.... Gilhus N.E.2003TTN, RYR1
26Transthyretin Val122Ile, accumulated Abeta, and inclusion-body myositis aspects in cultured muscle. (12874414)Askanas V.... Vattemi G.2003APP, TTR
27Analysis of HLA class I and II alleles in sporadic inclusion-body myositis. (14648147)Lampe J.B.... Lochmuller H.2003HLA-A, HLA-DQB1, HLA-DRB1
28Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging. (14569203)Askanas V.... Engel W.K.2003APBB1
29Myositis in children with meningococcal disease: a role for tumour necrosis factor-alpha and interleukin-8? (11972413)Carrol E.D.... Hart C.A.2002IL6, IL8
30Adhesion molecule expression in experimental myositis. (11870719)Ito T.... Tsuda T.2002ICAM1, VCAM1
31Eosinophilic myositis in a 9 year old boy (11785010)PeA+a Segura J.L.... LA^pez PisA^n J.2001DMD, PIK3C2A
32Histological data in inflammatory myositis (11965088)Mikol J.... Polivka M.2001APP, RPS27A
33Glycogenosis type V (McArdle's disease) mimicking atypical myositis. (11254243)Horneff G.... Neuen-Jacob E.2001PYGM
34Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)Zanusso G.... Monaco S.2001PRNP
35Prevalence in myositis of antibodies recognizing anti-U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin. (11703380)Kubo M.... Tamaki K.2001FBL
36Update on myositis-specific and myositis-associated autoantibodies. (11092195)Targoff I.N.2000NARS
37Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)Minshew P.T.... Samuels-Botts C.2000DMD
38Cyclin-dependent kinase 5 colocalizes with phosphorylated tau in human inclusion-body myositis paired-helical filaments and may play a role in tau phosphorylation. (11065131)Wilczynski G.M.... Askanas V.2000CDK5
39Autoantibodies in thymoma-associated myasthenia gravis with myositis or neuromyotonia. (10768628)Mygland A.... Aarli J.A.2000TTN, RYR1
40A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family. (10902757)Dode C.... Grateau G.2000TNFRSF1A
41Diagnostic muscle MRI abnormality in a patient with inclusion body myositis (9805998)Ono K.... Takamori M.1998CHKB
42Beta APP gene transfer into cultured human muscle induces inclusion-body myositis aspects. (9243602)Askanas V.... Engel W.K.1997APP
43Ubiquitin immunostaining and inclusion body myositis: study of 30 patients with inclusion body myositis. (9269823)Prayson R.A.... Cohen M.L.1997RPS27A
44Myositis induced by naked DNA immunization with the gene for histidyl-tRNA synthetase. (9287147)Blechynden L.M.... Lawson C.M.1997HARS
45Mechanisms of lysis by activated cytotoxic cells expressing perforin and granzyme-B genes and the protein TIA-1 in muscle biopsies of myositis. (8823683)Cherin P.... Emilie D.1996TIA1
46Nitric oxide production in relation to spontaneous B- cell lymphoma and myositis in SJL mice. (7545539)Tamir S.... Tannenbaum S.R.1995NOS2
47Myofibers from Duchenne/Becker muscular dystrophy and myositis express the intermediate filament nestin. (8021716)Sjoberg G.... Sejersen T.1994VIM, DES, NES
48Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau. (8291607)Askanas V.... Selkoe D.J.1994MAPT
49Effectiveness of intravenous immunoglobulins in poly myositis and dermatomyositis. An open trial in 15 patients (1706860)Cherin P.... Godeau P.1991PIK3C2A
50Autoantibodies to aminoacyl-transfer RNA synthetases for isoleucine and glycine. Two additional synthetases are antigenic in myositis. (2307838)Targoff I.N.1990GARS

Expression for genes affiliated with Myositis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Myositis

Pathways for genes affiliated with Myositis

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20KEGG, 36QIAGEN, 38Reactome, 10EMD Millipore, 41Thomson Reuters, 37R&D Systems, 3Cell Signaling Technology
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Pathways related to myositis according to GeneDecks:

(show top 50)    (show all 127)
idPathwayScoreTop Affiliating Genes
1Cell adhesion molecules (CAMs)2010.6CD80, HLA-G, ICOSLG, PTPRC, CD28, CD86
2RAR-Gamma-RXR-Alpha Degradation3610.5CD80, IL2, CCL21, CCL19, UBB, BMP1
3Alzheimers disease2010.5MME, CDK5, BACE2, BACE1, LRP1, IL1B
4CD28 Signaling in T-Helper Cell3610.4PTPRC, HLA-DRB3, HLA-DRB1, HLA-DQB1, CD28, PIK3C2A
5Immune System3810.2IFIH1, IL5, ATG5, ATG12, MX1, CIITA
6CTL Mediated Apoptosis3610.1HLA-DQB1, HLA-DQA1, HLA-C, HLA-A, GZMB, HLA-B
7Immune response IL-22 signaling pathway1010.1HLA-DQA1, BCL2L1, JUN, HLA-DRB1, CD86, FOS
8Immune response_IL-22 signaling pathway4110.0FOS, CD28, IL2, HLA-DQA1, CD86, HLA-DRB3
9Viral myocarditis2010.0HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-G
10NFAT Signaling and Lymphocyte Interactions369.9CCL19, CCL21, IL5, IL1A, BMP1, BCL2
11IL-6 Pathway369.9CXCL9, CXCL11, CCL19, BMP1, BAX, IL5
12Antigen processing and presentation209.9HLA-G, HLA-DRB1, CIITA, HLA-C, HLA-DRB3, HLA-DQA1
13IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types379.9BCL2, GZMA, GZMB, IL2, TNFRSF1A
14Apoptosis and Autophagy39.8BCL2L1, ATG5, GZMA, GZMB, MAP1LC3A, CASP1
15Graft-versus-host disease209.8HLA-C, HLA-DQA1, HLA-DRB3, HLA-B, HLA-A, IL2
16THC Differentiation Pathway369.7IFNG, CD86, IL2, TNFRSF1B, TNFRSF1A, HLA-DRB3
17ICos-ICosL Pathway in T-Helper Cell369.6PIK3C2A, CD28, PTPRC, CD86, HLA-DQA1, CD80
18Leishmaniasis209.5JUN, NOS2, FOS, IL1A, IL1B, IFNG
19Intestinal immune network for IgA production209.5HLA-DQA1, ICOSLG, IL5, CD86, IL6, CD80
20Autoimmune thyroid disease209.4PRF1, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
21Akt Signaling369.4CXCR3, CXCL9, CXCL11, TNFRSF1A, CCL21, IL6
22Allograft rejection209.4GZMB, HLA-B, HLA-A, IFNG, IL5, IL2
23Toxoplasmosis209.4HLA-DQB1, IFNG, LAMA2, LDLR, CIITA, BCL2
24Endothelin-1 Signaling Pathway369.3IL5, TNFSF13, BMP1, CXCL11, CASP1, CCL19
25Malaria209.1THBS1, ICAM1, IFNG, IL8, IL1B, CD36
26Molecular Mechanisms of Cancer369.1LAMA2, JUN, CD80, CXCL11, FOS, IL2
27ERK Signaling369.0CD80, IL1A, IL1B, IL2, CCL19, IL5
28Immune response_MIF-mediated glucocorticoid regulation418.9FOS, IL2, IL6, IL8, IFNG, ICAM1
29Immune response MIF-mediated glucocorticoid regulation108.9JUN, NOS2, VCAM1, FOS, IL2, IL6
30Rheumatoid arthritis208.7IL6, IL8, IFNG, ICAM1, HLA-DQA1, HLA-DRB1
31PGC1Alpha Pathway368.7BMP1, BCL2, BAX, CD80, IL1A, IL1B
32Tuberculosis208.7HLA-DRB1, BCL2, CIITA, NOS2, TNFRSF1A, HLA-DQB1
33Type I diabetes mellitus208.7GZMB, CD80, CD86, CD28, HLA-DQA1, HLA-DQB1
34MIF Mediated Glucocorticoid Regulation368.6CCL21, IL8, IL6, IL5, IL2, IL1B
35all-trans-Retinoic Acid Signaling in Brain368.6BMP1, BCL2, BAX, CD80, IL1A, IL1B
36PEDF Induced Signaling368.6IL1B, IL1A, FOS, CD80, BCL2L1, BCL2
37MIF Regulation of Innate Immune Cells368.5IL1B, IL2, IL5, IL6, IL8, CCL21
38Influenza A208.5TNFRSF1A, IL1B, JUN, MX1, CIITA, HLA-DQB1
39Cytokine Network368.4IL8, IL5, IL2, IL1B, IL1A, IFNA1
40PAK Pathway368.4MYLK, CXCL9, CXCL11, BMP1, IL8, TNFSF13
41STAT3 Pathway368.2CD28, CCL21, IL8, BCL2, BMP1, IL6
42Glucocorticoid Receptor Signaling368.1TNFRSF1A, TNFRSF1B, HELLS, IL6, CCL21, CCL19
43TGF-Beta Pathway368.0IL2, IL1B, TNFRSF1B, TNFRSF1A, CCL19, CD80
44Rho Family GTPases368.0IL5, CD80, IL8, CCL21, CCL19, TNFSF13
45Antioxidant Action of Vitamin-C368.0BMP1, CCL21, IL1B, CCL19, CXCL11, CXCL9
46JAK-STAT Pathway367.9CCL21, TNFRSF1B, IL1B, IL2, IL5, IL6
47SOCS Pathway367.9IL8, BAX, CD80, CCL21, IL1A, IL1B
48Cytokine-cytokine receptor interaction207.9IL8, IL17A, IL1A, IL1B, TNFSF13, CXCR3
49p38 Signaling367.7CXCL11, IL6, IL8, CCL19, CCL21, TNFRSF1A
50Neuroscience3INFNCAM1, BACE1, CDK5, FMR1, APBB1, APEX1

Compounds for genes affiliated with Myositis

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32Novoseek , 42Tocris Bioscience, 18HMDB, 34PharmGKB, 9DrugBank
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Compounds related to myositis according to GeneDecks:

(show top 50)    (show all 411)
idCompoundScoreTop Affiliating Genes
1sp 60012532 42 11.6VCAM1, IL17A, DUSP1
2lysine32 10.5MYOD1, PARK7, PARK2, CHKA, CHKB, LDLR
3ionomycin32 10.4SERPINA3, FOS, GZMA, GSN, IL5, GNLY
4glucose32 10.2MYLK, MYOD1, PARK2, CKM, CFB, MSTN
5ascorbic acid32 18 11.0CHKA, CHKB, LDLR, BACE1, CD36, MME
6hyaluronic acid32 18 10.9VIM, CD36, GZMB, MB, TTR, THBS1
7ivig32 9.9PIK3C2A, IL1RAPL2, CRP
8n acetylcysteine32 9.8VCAM1, CLU, CDK5, MMP2, MMP9, FOS
9pge232 9.7VCAM1, CIITA, LDLR, CD86, MME, IL17A
10doxorubicin32 34 9 9 12.7PIK3C2A, NCAM1, VIM, CLU, BCL2L1, CHKA
11glycogen32 18 10.4PIK3C2A, LRP1, VIM, PARK2, CKM, CHKA
12oxygen32 18 10.4PIK3C2A, SERPINA3, MYLK, MYOD1, CLU, PARK7
13arginine32 9.2PIK3C2A, SERPINA3, MYOD1, BMP1, UTRN, CKM
14estrogen32 8.8SERPINA3, MYLK, MYOD1, CLU, PARK2, CHKA
15testosterone32 9 18 9 11.7PIK3C2A, NCAM1, VIM, VCAM1, MYOD1, CLU
16fmlp32 8.5SERPINA3, VIM, VCAM1, CD47, MME, GSN
17atorvastatin32 34 9 18 9 12.5PIK3C2A, VCAM1, CHKA, CHKB, LDLR, MMP2
18fibrinogen32 8.2PIK3C2A, SERPINA3, VCAM1, CLU, CHKB, CD47
19paraffin32 8.2NCAM1, SERPINA3, VIM, VCAM1, MYOD1, CLU
20triptolide32 8.0BCL2, BAX, JUN, CD86, IL1B, IL2
21cyclosporin a32 42 9.0PIK3C2A, CIITA, CHKB, LDLR, JUN, CD28
22simvastatin32 34 42 9 18 9 12.9PIK3C2A, VCAM1, CIITA, CHKA, CHKB, LDLR
23sb 20358032 42 8.9VIM, VCAM1, BCL2, BCL2L1, CD36, MMP2
24polyinosinic-polycytidylic acid32 7.8VCAM1, CIITA, IL2, IL5, IL6, IL8
25prednisolone32 9 9 9.7PIK3C2A, VCAM1, CHKB, MMP2, GZMB, IL1RAPL2
26rantes32 7.1VCAM1, CIITA, MX1, JUN, MMP9, GZMA
27herbimycin a32 42 7.9VCAM1, JUN, CD28, CD36, MMP2, MMP9
28lactate32 6.8PIK3C2A, NCAM1, VIM, VCAM1, CLU, CKM
29neopterin32 6.7CHKB, MX1, GZMB, IL1A, IL1B, IL1RAPL2
30actinomycin d32 6.6VIM, MYOD1, CLU, BCL2, BCL2L1, CIITA
31alanine32 6.6PIK3C2A, NCAM1, VCAM1, LMNA, MYLK, MYOD1
32genistein32 9 18 9 9.6VIM, VCAM1, BCL2, BCL2L1, CHKA, LDLR
33aspartate32 INFPIK3C2A, VIM, MYLK, BMP1, CHKB, LDLR
34phosphatidylserine32 9 9 INFVIM, BCL2, CD47, GZMB, GSN, MAPT
35nitric oxide32 9 18 9 INFNCAM1, VCAM1, UTRN, PARK2, CKM, CIITA
36atp32 INFPIK3C2A, NCAM1, VIM, VCP, LMNA, MYLK
37cysteine32 INFLRP1, SERPINA3, CLU, PARK7, BCL2L1, CKM
38threonine32 INFMYLK, MYOD1, PARK2, KARS, CDK5, IL1RAPL2
39polyacrylamide32 INFSERPINA3, CHKA, CHKB, CFB, GSN, IL1RN
40dexamethasone32 42 34 9 9 INFLRP1, NCAM1, SERPINA3, VIM, VCAM1, CLU
41tacrolimus32 34 9 9 INFCHKB, CD28, CD36, CD86, GZMB, INS
42nmda32 42 INFLRP1, NCAM1, VIM, PARK2, BCL2L1, LDLR
43cholesterol32 9 18 9 INFPIK3C2A, LRP1, SERPINA3, VLDLR, VCAM1, LMNA
44heparin32 9 18 9 INFPIK3C2A, LRP1, NCAM1, SERPINA3, VLDLR, VIM
45adenylate32 INFVIM, VCAM1, PABPC1P1, CKM, CHKA, CHKB
46glutamate32 INFNCAM1, VIM, BMP1, CLU, CKM, CHKA
47retinoic acid32 42 18 INFLRP1, NCAM1, VCAM1, LMNA, MYOD1, CLU
48leucine32 INFLRP1, SERPINA3, VIM, LMNA, MYOD1, PARK2
49calcium32 9 18 9 INFPIK3C2A, LRP1, SERPINA3, VCP, LMNA, MYLK
50lipid32 INFPIK3C2A, LRP1, NCAM1, SERPINA3, VLDLR, VIM

GO Terms for genes affiliated with Myositis

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Sources:
12Gene Ontology
See all sources

Cellular components related to myositis according to GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:03066610.4RPS27A, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, CAV1
2MHC class II protein complexGO:04261310.3HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3
3external side of plasma membraneGO:00989710.3ICOSLG, HLA-DRB1, HLA-DRB3, PTPRC, THBS1, CXCL9
4integral to lumenal side of endoplasmic reticulum membraneGO:07155610.2HLA-G, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
5ER to Golgi transport vesicle membraneGO:01250710.2HLA-G, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
6clathrin-coated endocytic vesicle membraneGO:03066910.2HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, LDLR
7cell surfaceGO:00998610.2HSPA9, CAV1, TNFRSF1A, DMD, SPTB, CRYAB
8endoplasmic reticulumGO:00578310.0EMD, RTN4, SQSTM1, PRNP, PSEN1, HMGCR
9protein complexGO:0432349.8RTN4, SPTB, DMD, TNFRSF1A, CAV1, CAPN3
10integral to plasma membraneGO:0058879.8HLA-C, HLA-DQA1, HLA-DRB1, HLA-DRB3, TNFRSF1A, PTPRC
11cytosolGO:0058298.3DMD, PYGM, TNFSF13, TUBG1, CAV1, CASP1
12cytoplasmGO:0057378.2TRIM21, DUSP6, SP7, SPTB, SNCA, TUBG1
13extracellular spaceGO:0056155.7CST3, APOE, CCL21, CCL19, IFNG, ICAM1
14extracellular regionGO:0055764.9TNFRSF1B, TNFRSF1A, HLA-C, CASP1, IFNG, CCL19
15axonGO:030424INF, SNCA, TNFRSF1A, MAPT, APP, MME
16plasma membraneGO:005886INFTNFRSF1B, TNFRSF1A, HLA-G, HLA-DRB3, HLA-DRB1, HLA-DQB1

Biological processes related to myositis according to GeneDecks:

(show top 50)    (show all 68)
idNameGO IDScoreTop Affiliating Genes
1stress-activated MAPK cascadeGO:05140310.8RPS27A, UBB, JUN, FOS, DUSP4, DUSP6
2toll-like receptor signaling pathwayGO:00222410.8RPS27A, DUSP6, DUSP4, FOS, CD86, JUN
3nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.8RPS27A, CASP1, APP, UBB, BCL2L1, BCL2
4neuron apoptotic processGO:05140210.7GAPDH, PSEN1, APP, CDK5, BAX, BCL2
5T cell receptor signaling pathwayGO:05085210.7PSEN1, RPS27A, PTPRC, HLA-DRB3, HLA-DRB1, HLA-DQB1
6T cell costimulationGO:03129510.7HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, CAV1, ICOSLG
7cleavage of laminGO:00692210.7BAX, GZMA, GZMB
8tRNA aminoacylation for protein translationGO:00641810.6GARS, HARS, AARS, TARS2, TARS, KARS
9negative regulation of type I interferon productionGO:03248010.6RPS27A, IFIH1, ATG5, ATG12, UBB
10muscle organ developmentGO:00751710.6GAA, EMD, SIRT1, NEB, CRYAB, DMD
11cholesterol transportGO:03030110.6CAV1, APOA1, CD36, LDLR
12negative regulation of neuron apoptotic processGO:04352410.6PSEN1, SNCA, JUN, BAX, BCL2L1, BCL2
13detection of bacteriumGO:01604510.5HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
14muscle contractionGO:00693610.5EMD, RYR1, DES, TTN, CRYAB, UTRN
15release of cytochrome c from mitochondriaGO:00183610.5JUN, BAX, BCL2L1, BCL2, CLU
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.5HLA-G, HLA-C, HLA-B, HLA-A
17response to organic cyclic compoundGO:01407010.5DUSP6, CASP1, ICAM1, CCL19, IL1RN, IL1A
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.5RPS27A, HLA-G, HLA-C, HLA-B, HLA-A, CD36
19antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4RPS27A, UBB, CD36, HLA-A, HLA-B, HLA-C
20positive regulation of interleukin-2 biosynthetic processGO:04508610.4IL1B, IL1A, CD80, CD86, CD28
21innate immune responseGO:04508710.4IL1RAPL2, APP, IFIH1, CASP1, DUSP4, DUSP6
22response to copper ionGO:04668810.4BCL2, IL1A, ICAM1, PRNP
23interferon-gamma-mediated signaling pathwayGO:06033310.3HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-G, HLA-C
24muscle filament slidingGO:03004910.3NEB, DES, TTN, DMD, MYBPC1, VIM
25cell deathGO:00821910.2GARS, TARDBP, TREX1, HSPB3, APOE, IL17A
26response to gamma radiationGO:01033210.2PTPRC, CAV1, IL1B, IL1A, BAX, BCL2
27anti-apoptosisGO:00691610.2CRYAB, RPS27A, THBS1, PSEN1, PRNP, SQSTM1
28MyD88-independent toll-like receptor signaling pathwayGO:00275610.2RPS27A, DUSP6, DUSP4, FOS, JUN, UBB
29antigen processing and presentation of peptide antigen via MHC class IGO:00247410.1RPS27A, HLA-G, HLA-C, HLA-B, HLA-A, CD36
30agingGO:00756810.1RTN4, CRYAB, HMGCR, IL1B, GSN, JUN
31positive regulation of membrane protein ectodomain proteolysisGO:05104410.1TNFRSF1B, IFNG, APOE, IL1B
32positive regulation of anti-apoptosisGO:04576810.1SIRT1, DUSP1, CAV1, APEX1, IL6, CD28
33positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.0TGM2, RPS27A, TNFRSF1A, CASP1, CCL19, CCL21
34response to ethanolGO:0454719.9PRF1, TNFRSF1A, ICAM1, GSN, MMP9, MSTN
35positive regulation of T cell proliferationGO:0421029.9PTPRC, IFNG, CCL19, IL6, IL1B, CD28
36defense response to virusGO:0516079.9CXCL9, PRF1, PTPRC, IFNG, IL6, CD86
37response to drugGO:0424939.9ICAM1, CASP1, CAV1, DUSP6, SNCA, THBS1
38positive regulation of apoptotic processGO:0430659.8SIRT1, PTPRC, DUSP6, DUSP1, APBB1, IL1B
39regulation of apoptotic processGO:0429819.8SIRT1, RTN4, RPS27A, IFIH1, IL6, CDK5
40cellular response to interleukin-1GO:0713479.7ICAM1, IL8, IL17A, MMP9, VLDLR
41cellular response to lipopolysaccharideGO:0712229.5CD36, IL8, IFNG, ICAM1, TNFRSF1B, NOS2
42positive regulation of NF-kappaB transcription factor activityGO:0510929.4RPS27A, CAPN3, ICAM1, IL6, IL1B, INS
43virus-host interactionGO:0190489.4SIRT1, TNFRSF1A, HLA-C, HLA-B, HLA-A, CAV1
44negative regulation of apoptotic processGO:0430669.0SIRT1, NES, THBS1, CAPN3, IL6, IL1RN
45apoptotic processGO:0069158.9TNFRSF1B, TNFRSF1A, CASP1, CAPN3, IFNG, RPS27A
46immune responseGO:0069558.8HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, TNFSF13
47cytokine-mediated signaling pathwayGO:0192218.7NCAM1, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1
48acute-phase responseGO:0069538.4CRP, IL6, IL1RN, INS, SERPINA3
49response to hypoxiaGO:0016668.3PYGM, CRP, CRYAB, NOS2, THBS1, RYR1
50inflammatory responseGO:0069547.7CCL19, TNFRSF1A, TNFRSF1B, CRP, C4A, CXCL11

Molecular functions related to myositis according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.4HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
2BH3 domain bindingGO:05143410.3BCL2, BCL2L1, BAX
3structural constituent of muscleGO:00830710.2TTN, DMD, CAPN3, MYBPC1, NEB
4MHC class I receptor activityGO:03239310.1HLA-G, HLA-C, HLA-B, HLA-A
5identical protein bindingGO:04280210.0SNCA, TTN, THBS1, PRNP, SQSTM1, SIRT1
6receptor bindingGO:0051029.6NOS2, TNFSF13, HLA-G, HLA-B, HLA-A, CAV1
7protease bindingGO:0020209.5RYR1, CST3, TTN, TNFRSF1A, INS, CD28
8cytokine activityGO:0051258.7CXCL9, TNFSF13, IFNG, IL6, IL5, IL2
9protein bindingGO:005515INFAPOE, TRIM21, TNFRSF1A, TNFRSF1B, DUSP1, PTPRC

Sources for Myositis

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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