MCID: MYS005
MIFTS: 66

Myositis malady

Muscle diseases category
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Summaries for Myositis

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8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Myositis means inflammation of the muscles that you use to move your body. an injury, infection, or autoimmune disease can cause it. two specific kinds are polymyositis and dermatomyositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. other symptoms of myositis may include fatigue after walking or standing tripping or falling trouble swallowing or breathing doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. there is no cure for these diseases, but you can treat the symptoms. polymyositis and dermatomyositis are first treated with high doses of a corticosteroid. other options include medications, physical therapy, exercise, heat therapy, assistive devices, and rest. nih: national institute of neurological disorders and stroke

MalaCards: Myositis, also known as inflammatory disorder of muscle, is related to inclusion body myositis and polymyositis. An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and African trypanosomiasis. The drugs carisoprodol and chlorphenesin and the compounds thioflavine s and happ have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin, and related mouse phenotypes are other and nervous system.

Disease Ontology:8 A myopathy characterized by muscle inflamation.

Wikipedia:65 Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely... more...

Description from OMIM:47 160750

Aliases & Classifications for Myositis

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 47OMIM, 35MeSH, 25ICD10
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Related Diseases for Myositis

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17GeneCards, 18GeneDecks
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Diseases related to Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 367)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis31.8CXCR3, CHKB
2polymyositis30.9VCAM1, HLA-B, CHKB, PRNP, ICAM1, RPS27A
3dermatomyositis30.8HLA-B, CHKB, ICAM1, VCAM1, PRNP, SERPINA3
4myopathy30.8RPS27A, APP, PRNP, CHKB, HLA-B, MSTN
5arthritis30.6ICAM1, CXCR3, SERPINA3, HLA-B
6muscular dystrophy30.6MSTN, CHKB, CAPN3
7vasculitis30.4ICAM1, HLA-B, VCAM1
8systemic lupus erythematosus30.3RPS27A, CXCR3, ICAM1, VCAM1
9rheumatoid arthritis30.3CHKB, SERPINA3, VCAM1, MME, CXCR3, ICAM1
10encephalitis30.2VCAM1, HLA-B, APP
11idiopathic myopathy30.2HLA-B, CHKB
12pneumonia30.1ICAM1, MME
13hypertension30.1ICAM1, VCAM1, MME
14leukemia30.1HLA-B, ICAM1, CXCR3, SERPINA3, MME
15glomerulonephritis30.1ICAM1, RPS27A, VCAM1, MME
16parkinson's disease30.1RPS27A, MAPT
17limb-girdle muscular dystrophy30.0CAPN3, CHKB
18systemic scleroderma30.0VCAM1, MME, ICAM1
19dermatitis30.0ICAM1, VCAM1, CXCR3
20sarcoidosis29.9ICAM1, CXCR3, SERPINA3
21ulcerative colitis29.9ICAM1, CHKB, HLA-B, CXCR3
22graves' disease29.9HLA-B, VCAM1, ICAM1, CXCR3
23b-cell lymphomas29.9CXCR3, MME, HLA-B
24ischemia29.9ICAM1, MME, MAPT, HLA-B, CHKB
25meningoencephalitis29.9APP
26alzheimer's disease29.8SERPINA3, BACE1, APP, CHKB, MME, MAPT
27rheumatoid vasculitis29.8ICAM1, VCAM1
28tauopathy29.8RPS27A, MAPT, APP
29uveitis29.7ICAM1, CXCR3, HLA-B
30autoimmune thyroiditis29.7ICAM1, CXCR3, CHKB, HLA-B
31burkitt's lymphoma29.7CXCR3, ICAM1, MME
32neuromuscular disease29.7PRNP, CHKB, MSTN, CAPN3
33multiple system atrophy29.6SERPINA3, RPS27A, MAPT, PRNP
34amyloidosis29.6SERPINA3, PRNP, MME, APP, HLA-B, RPS27A
35creutzfeldt-jakob disease29.6MAPT, RPS27A, SERPINA3, APP, PRNP
36stomach cancer29.6HLA-B, SERPINA3, MME, PRNP
37amyotrophic lateral sclerosis29.6APP, PRNP, RPS27A, CHKB, MAPT, CAPN3
38lung cancer29.5MME, SERPINA3, CXCR3, HLA-B
39myositis ossificans11.1
40focal myositis10.8
41fibrodysplasia ossificans progressiva10.5
42fasciitis10.4
43myositis fibrosa10.4
44dysphagia10.4
45pyomyositis10.4
46granulomatous myositis10.3
47influenza10.3
48myocarditis10.3
49tetanus10.3
50interstitial lung disease10.3

Graphical network of the top 20 diseases related to Myositis:



Diseases related to myositis

Symptoms for Myositis

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47OMIM
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Clinical features from OMIM:

160750

Drugs & Therapeutics for Myositis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Myositis

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Anatomical Context for Myositis

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33MalaCards
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MalaCards organs/tissues related to Myositis:

33
Testes, Bone, Skin, T cells, Skeletal muscle, Lung, Brain, Tongue, B cells, Thyroid, Myeloid, Lymph node, Heart, Bone marrow, Ovary, Spinal cord, Breast, Monocytes, Small intestine, Eye, Endothelial, Kidney

Animal Models for Myositis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Myositis:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.4APP, MME, PRNP, MAPT, BACE1
2MP:00036317.8APP, CHKB, PRNP, ICAM1, MAPT, BACE1
3MP:00053867.7HLA-B, APP, CHKB, PRNP, MSTN, MAPT
4MP:00028737.5APP, PRNP, CXCR3, MAPT, CAPN3, BACE1
5MP:00053697.5APP, CHKB, PRNP, MSTN, ICAM1, MAPT
6MP:00030127.5BACE1, HLA-B, APP, VCAM1, PRNP, MSTN
7MP:00053787.3APP, VCAM1, PRNP, MSTN, ICAM1, MAPT
8MP:00053847.0APP, PRNP, CXCR3, MSTN, ICAM1, MAPT
9MP:00107686.8HLA-B, APP, VCAM1, PRNP, CXCR3, MSTN
10MP:00053876.8HLA-B, APP, VCAM1, MME, PRNP, CXCR3
11MP:00053766.7APP, VCAM1, MME, CHKB, PRNP, CXCR3

Publications for Myositis

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52PubMed
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Articles related to Myositis:

(show top 50)    (show all 1572)
idTitleAuthorsYear
1
Orbital myositis in BehAset's disease. (24326194)
2013
2
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
3
Complete Genome Sequence of Encapsulated Haemophilus influenzae Type f KR494, an Invasive Isolate That Caused Necrotizing Myositis. (24092777)
2013
4
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
5
Successful treatment of calcinosis with infliximab in a patient with systemic sclerosis/myositis overlap syndrome. (24255162)
2013
6
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
7
Gemcitabine-induced radiation recall myositis in a patient with dermatomyositis. (24283707)
2013
8
Dengue Viral Myositis Complicated with Rhabdomyolysis and Superinfection of Methicillin-Resistant Staphylococcus aureus. (23476836)
2013
9
Gemcitabine induced myositis in patients with pancreatic cancer: case reports and topic review. (21811892)
2012
10
A case of parosteal osteosarcoma with a rare complication of myositis ossificans. (23194024)
2012
11
Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort. (22884621)
2012
12
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
13
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
14
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
15
Morphoea with myositis: a rare association. (22937437)
2011
16
Vaccination-induced myositis with intramuscular sterile abscess formation. (21479517)
2011
17
Inclusion body myositis: diagnosis, pathogenesis, and treatment options. (21444018)
2011
18
Myositis ossificans of the supinator muscle causing posterior interosseous nerve palsy: a case report. (20672400)
2010
19
Dengue myositis and myocarditis. (20739801)
2010
20
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
21
Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease. (19929661)
2009
22
Inclusion body myositis and HIV infection. (18641890)
2008
23
Bilateral and recurrent myositis ossificans in an athlete: a case report and review of treatment options. (16442986)
2006
24
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
25
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
26
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
27
Circumscribed myositis ossificans of the iliopsoas muscle. Description of a case followed-up after 1 and 14 years. (15645792)
2004
28
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
29
Myositis ossificans as a complication of a muscle tendon junction strain of long head of biceps. A case report. (12629466)
2003
30
Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis. (12667656)
2003
31
Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis. (12124873)
2002
32
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
33
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
34
Update on myositis-specific and myositis-associated autoantibodies. (11092195)
2000
35
Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)
2000
36
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
37
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
38
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
39
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
40
Hepatitis C and inclusion body myositis. (8792712)
1996
41
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
42
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
43
Myositis ossificans progressiva: a 10-year follow-up on a patient treated with etidronate disodium. (7734885)
1994
44
Myositis ossificans of medial pterygoid muscle. A cause for temporomandibular joint ankylosis. (1603562)
1992
45
Type-I hypersensitivity as a component of eosinophilic myositis (muscular sarcocystosis) in cattle. (2496630)
1989
46
Myositis ossificans. A clinicopathologic study of 21 cases. (3866484)
1985
47
Severe influenza myositis. (3974500)
1985
48
Myositis ossificans localisata as a complication of tetanus. (525320)
1979
49
Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically verified case. (5228630)
1967
50
Myositis Ossificans Progressiva. (19994086)
1961

Variations for Myositis

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Expression for genes affiliated with Myositis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myositis

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Pathways for genes affiliated with Myositis

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50PathCards, 60Thomson Reuters, 30KEGG, 53QIAGEN, 54R&D Systems, 55Reactome, 5Cell Signaling Technology, 38NCBI BioSystems Database
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Compounds for genes affiliated with Myositis

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45Novoseek, 3BitterDB, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1thioflavine s4510.1MAPT, RPS27A, APP
2happ459.6APP, MME, BACE1
3chloroquine45 3 51 29 1113.5BACE1, MAPT, RPS27A, APP
4lactacystin459.4APP, RPS27A, MAPT, BACE1
5n acetylcysteine459.3VCAM1, CHKB, ICAM1, RPS27A, MAPT
6simvastatin45 51 61 29 24 1114.2ICAM1, BACE1, CHKB, VCAM1, APP
7formate459.2MAPT, RPS27A, PRNP, APP
84-hydroxynonenal45 2410.1MAPT, BACE1, RPS27A, APP, MME
9tacrolimus45 51 1111.1CXCR3, RPS27A, HLA-B, APP, CHKB
10mg 13245 6110.1ICAM1, RPS27A, MAPT, CAPN3
11sodium dodecylsulfate459.0MAPT, APP, PRNP, RPS27A
12endotoxin459.0HLA-B, ICAM1, VCAM1, CHKB, CXCR3
13fibrinogen459.0ICAM1, HLA-B, SERPINA3, CHKB, VCAM1
14guanidine hydrochloride458.9RPS27A, SERPINA3, CHKB, PRNP
15sodium nitroprusside458.9VCAM1, APP, MME, CXCR3
16actinomycin d458.9MME, ICAM1, RPS27A, APP, MAPT
17formaldehyde45 249.9MAPT, APP, RPS27A, PRNP
18adenylate458.9APP, VCAM1, MME, CHKB, RPS27A, HLA-B
19dopamine45 29 24 1111.7RPS27A, MAPT, CHKB, MME, SERPINA3, APP
20valine458.7RPS27A, MAPT, PRNP, SERPINA3, APP
21cyclosporin a45 29 6110.7HLA-B, MME, CHKB, ICAM1, RPS27A, MAPT
22lactate458.6MAPT, RPS27A, ICAM1, HLA-B, MME, CHKB
23acetylcholine45 51 29 24 1112.6BACE1, MAPT, MME, RPS27A, SERPINA3, APP
24fmlp458.5VCAM1, MME, ICAM1, SERPINA3, CXCR3
25testosterone45 61 24 1111.3RPS27A, CHKB, MSTN, VCAM1, HLA-B, MAPT
26vegf458.3MME, RPS27A, APP, CHKB, ICAM1, VCAM1
27glucose458.2MSTN, CHKB, MAPT, MME, SERPINA3, HLA-B
28nitric oxide45 24 1110.1CXCR3, VCAM1, MME, CHKB, ICAM1, HLA-B
29retinoic acid45 249.1SERPINA3, MAPT, HLA-B, APP, VCAM1, MME
30aspartate458.0MAPT, PRNP, HLA-B, RPS27A, APP, VCAM1
31glutamate458.0MME, APP, MAPT, RPS27A, CHKB, PRNP
32hydrogen45 248.9CHKB, MME, BACE1, RPS27A, PRNP
33alanine457.7MAPT, PRNP, RPS27A, BACE1, CHKB, VCAM1
34cysteine457.6CHKB, MAPT, BACE1, VCAM1, SERPINA3, MME
35estrogen457.6MAPT, BACE1, RPS27A, CXCR3, CHKB, MME
36polysaccharide457.6CHKB, PRNP, BACE1, RPS27A, ICAM1, SERPINA3
37paraffin457.6MAPT, RPS27A, PRNP, CHKB, MME, VCAM1
38creatinine457.5MAPT, RPS27A, CXCR3, CAPN3, MME, SERPINA3
39pge2457.5ICAM1, VCAM1, MME, HLA-B, RPS27A, CXCR3
40lipid457.4HLA-B, APP, SERPINA3, VCAM1, PRNP, BACE1
41zinc45 248.4PRNP, CHKB, MME, SERPINA3, HLA-B, RPS27A
42heparin45 29 24 1110.4MAPT, VCAM1, BACE1, CHKB, PRNP, APP
43h2o2457.4APP, MAPT, RPS27A, ICAM1, PRNP, CHKB
44superoxide45 248.4CXCR3, BACE1, VCAM1, MME, CHKB, PRNP
45cholesterol45 29 24 1110.4PRNP, VCAM1, SERPINA3, HLA-B, CXCR3, BACE1
46dexamethasone45 51 29 1110.2MME, MSTN, HLA-B, APP, SERPINA3, VCAM1
47tyrosine457.1HLA-B, MME, CXCR3, ICAM1, RPS27A, BACE1
48arginine456.8SERPINA3, HLA-B, PRNP, MAPT, VCAM1, MME
49serine456.5BACE1, HLA-B, RPS27A, CXCR3, PRNP, MME
50oxygen45 247.4ICAM1, MSTN, CXCR3, MME, PRNP, CHKB

GO Terms for genes affiliated with Myositis

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16Gene Ontology
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Cellular components related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1APP, MME, MAPT, BACE1
2cell surfaceGO:0099869.1HLA-B, APP, VCAM1, BACE1
3external side of plasma membraneGO:0098978.9ICAM1, CXCR3, VCAM1
4Golgi apparatusGO:0057948.7BACE1, PRNP, VCAM1, APP
5integral component of plasma membraneGO:0058878.0HLA-B, APP, MME, CXCR3, ICAM1, BACE1
6extracellular vesicular exosomeGO:0700627.5HLA-B, APP, SERPINA3, MME, PRNP, ICAM1
7plasma membraneGO:0058866.5CAPN3, HLA-B, APP, VCAM1, MME, PRNP

Biological processes related to Myositis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:00808810.2APP, MAPT
2membrane to membrane dockingGO:02261410.1VCAM1, ICAM1
3response to muscle activityGO:0148509.9MSTN, CAPN3
4cellular response to glucose stimulusGO:0713339.8ICAM1, VCAM1
5interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-B, VCAM1, ICAM1
6regulation of immune responseGO:0507769.8ICAM1, VCAM1, HLA-B
7beta-amyloid metabolic processGO:0504359.8MME, BACE1
8response to ethanolGO:0454719.7ICAM1, MSTN, VCAM1
9leukocyte cell-cell adhesionGO:0071599.7VCAM1, ICAM1
10cellular copper ion homeostasisGO:0068789.6APP, PRNP
11positive regulation of NF-kappaB transcription factor activityGO:0510929.6ICAM1, RPS27A, CAPN3
12cytokine-mediated signaling pathwayGO:0192219.6RPS27A, ICAM1, VCAM1, HLA-B
13positive regulation of release of sequestered calcium ion into cytosolGO:0512819.6CAPN3, CXCR3
14heterophilic cell-cell adhesionGO:0071579.5ICAM1, VCAM1
15response to copper ionGO:0466889.5PRNP, ICAM1
16proteolysisGO:0065089.2MME, CAPN3, BACE1
17cell adhesionGO:0071559.1ICAM1, CXCR3, VCAM1, APP
18apoptotic processGO:0069158.9CAPN3, MAPT, RPS27A, CXCR3

Products for genes affiliated with Myositis

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Sources for Myositis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet