MCID: MYS005
MIFTS: 67

Myositis malady

Summaries for Myositis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Myositis means inflammation of the muscles that you use to move your body. an injury, infection, or autoimmune disease can cause it. two specific kinds are polymyositis and dermatomyositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. other symptoms of myositis may include fatigue after walking or standing tripping or falling trouble swallowing or breathing doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. there is no cure for these diseases, but you can treat the symptoms. polymyositis and dermatomyositis are first treated with high doses of a corticosteroid. other options include medications, physical therapy, exercise, heat therapy, assistive devices, and rest. nih: national institute of neurological disorders and stroke

MalaCards: Myositis, also known as inflammatory disorder of muscle, is related to inclusion body myositis and dermatomyositis. An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The drugs carisoprodol and chlorphenesin and the compounds arginine and cysteine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A myopathy characterized by muscle inflamation.

Wikipedia:63 Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely... more...

Description from OMIM:46 160750

Aliases & Classifications for Myositis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt, 25ICD10
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Related Diseases for Myositis

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17GeneCards, 18GeneDecks
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Diseases related to Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis31.7CXCL9, CXCR3, CHKB
2dermatomyositis30.9ICAM1, HLA-B, PRNP, CHKB, VCAM1, SERPINA3
3myopathy30.9COX5A, MSTN, MYOD1, CHKB, PRNP, HLA-B
4arthritis30.6COX5A, ICAM1, HLA-B, CXCR3, CXCL9, SERPINA3
5muscular dystrophy30.5CAPN3, CHKB, MYOD1, MSTN
6influenza30.4CXCL9, CXCR3, HLA-B
7myocarditis30.4CHKB
8rheumatoid arthritis30.3ICAM1, CHKB, CXCR3, CXCL9, MME, VCAM1
9hepatitis30.3HLA-B
10skin disease30.3CXCL9
11alzheimer's disease30.2SNCA, PSEN1, APP, RPS27A, COX5A, PRNP
12neuropathy30.2MSTN, MYOD1, CAPN3
13vasculitis30.2ICAM1, HLA-B, VCAM1
14sarcoma30.2MYOD1
15systemic lupus erythematosus30.2RPS27A, ICAM1, CXCR3, VCAM1
16leukemia30.1ICAM1, HLA-B, CXCR3, MME, SERPINA3
17encephalitis30.1APP, HLA-B, CXCL9, VCAM1
18hepatitis c30.1CXCR3
19brain disease30.0SERPINA3, MAPT, BACE1, PRNP, SNCA, PSEN1
20glomerulonephritis30.0RPS27A, ICAM1, CXCL9, MME, VCAM1
21sarcoidosis30.0SERPINA3, CXCL9, CXCR3, ICAM1
22hypertension30.0VCAM1, MME, ICAM1
23pneumonia30.0MME, ICAM1
24idiopathic myopathy30.0CHKB, HLA-B
25amyloidosis29.9RPS27A, SERPINA3, MME, MAPT, BACE1, PRNP
26ischemia29.9COX5A, ICAM1, PSEN1, HLA-B, SNCA, CHKB
27graves' disease29.9VCAM1, CXCR3, HLA-B, ICAM1
28adenocarcinoma29.8SERPINA3, MME, MAPT, HLA-B
29motor neuron disease29.8MAPT, SNCA, RPS27A, COX5A
30parkinson's disease29.8MAPT, SNCA, RPS27A
31ulcerative colitis29.8ICAM1, HLA-B, CHKB, CXCR3
32duchenne muscular dystrophy29.8CHKB, MYOD1, MSTN
33ankylosing spondylitis29.8HLA-B
34chondrosarcoma29.8SERPINA3
35synovitis29.8VCAM1, ICAM1
36dermatitis29.8ICAM1, CXCR3, CXCL9, VCAM1
37amyotrophic lateral sclerosis29.6RPS27A, CAPN3, APP, PSEN1, SNCA, PRNP
38polymyositis29.6RPS27A, ICAM1, HLA-B, PRNP, CHKB, VCAM1
39tauopathy29.6RPS27A, APP, PSEN1, SNCA, MAPT
40multiple system atrophy29.6RPS27A, SNCA, PRNP, MAPT, SERPINA3
41prion disease29.6MAPT, PRNP, PSEN1, APP
42autoimmune thyroiditis29.6ICAM1, HLA-B, CHKB, CXCR3
43neuromuscular disease29.6CAPN3, PRNP, CHKB, MSTN
44pancreatic cancer29.6SERPINA3, RPS27A, COX5A
45myeloma29.6ICAM1, HLA-B, VCAM1
46burkitt's lymphoma29.6ICAM1, CXCR3, CXCL9, MME
47diabetes mellitus29.6VCAM1, HLA-B, ICAM1
48pheochromocytoma29.6APP, PSEN1, SNCA, BACE1
49hepatocellular carcinoma29.6MME, CXCL9
50uveitis29.6CXCL9, CXCR3, HLA-B, ICAM1

Graphical network of the top 20 diseases related to Myositis:



Diseases related to myositis

Clinical Features for Myositis

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46OMIM
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Clinical features from OMIM:

160750

Drugs & Therapeutics for Myositis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Myositis

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Anatomical Context for Myositis

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32MalaCards
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MalaCards organs/tissues related to Myositis:

32
Bone, Testes, Skin, T cells, Skeletal muscle, Lung, Brain, Tongue, B cells, Thyroid, Bone marrow, Lymph node, Myeloid, Heart, Ovary, Spinal cord, Breast, Monocytes, Small intestine, Eye, Endothelial, Kidney

Animal Models for Myositis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myositis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.4PRNP, SNCA, HLA-B, PSEN1, APP, ICAM1
2MP:000538711.2ICAM1, APP, PSEN1, HLA-B, SNCA, PRNP
3MP:000536911.2MSTN, CAPN3, ICAM1, APP, PSEN1, PRNP
4MP:000538411.2ICAM1, APP, PSEN1, HLA-B, SNCA, PRNP
5MP:000537811.2SNCA, PSEN1, APP, ICAM1, CAPN3, PRNP
6MP:000537611.1SNCA, PSEN1, APP, ICAM1, CAPN3, PRNP
7MP:000301211.0CAPN3, APP, SNCA, PRNP, BACE1, MAPT
8MP:000363111.0ICAM1, APP, PSEN1, HLA-B, SNCA, PRNP
9MP:000539511.0APP, PSEN1, PRNP, BACE1, MAPT, MME
10MP:000287310.8CAPN3, APP, PSEN1, PRNP, BACE1, MAPT
11MP:000538610.8APP, PSEN1, HLA-B, SNCA, PRNP, CHKB
12MP:001077110.7MME, MAPT, BACE1, PSEN1, APP
13MP:000538510.5CAPN3, ICAM1, PSEN1, SNCA, MYOD1, CXCR3

Publications for Myositis

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50PubMed
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Articles related to Myositis:

(show top 50)    (show all 1592)
idTitleAuthorsYear
1
Inclusion-body myositis associated with Alzheimer's disease. (23606855)
2013
2
A case of progressive quadriceps weakness and hyperCKemia mimicking inclusion body myositis. (24022920)
2013
3
Overexpression of autophagic proteins in the skeletal muscle of sporadic inclusion body myositis. (23452291)
2013
4
Detection of multiple muscle involvement in eosinophilic myositis with A^a8,F-FDG PET/CT. (23624764)
2013
5
Cricopharyngeal myotomy for cricopharyngeus stricture in an inclusion body myositis patient with hiatus hernia: a learning experience. (23345496)
2013
6
VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model. (21193952)
2012
7
Activation of the I^-secretase complex and presence of I^-secretase-activating protein may contribute to AI^42 production in sporadic inclusion-body myositis muscle fibers. (22750528)
2012
8
Cardiac involvement in juvenile overlap-myositis detected by cardiac magnetic resonance imaging. (20971516)
2011
9
Adalimumab for recurrent orbital myositis in Crohn's disease: report of a case with a 3-year follow-up. (21575896)
2011
10
Paraspinal tumoral calcinosis in a child with systemic sclerosis/myositis overlap. (21735178)
2011
11
Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis. (21730129)
2011
12
Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. (21728907)
2011
13
Myositis proliferans: diagnosis and therapy of a pseudosarcomatous soft tissue lesion. (21626026)
2011
14
Myositis ossificans. (22224121)
2011
15
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies. (21046407)
2010
16
A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis. (20809047)
2010
17
Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. (18922603)
2010
18
Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation. (20334640)
2010
19
Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease. (19929661)
2009
20
Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. (18191026)
2008
21
Raised troponin T in inclusion body myositis is common and serum levels are persistent over time. (16920359)
2006
22
Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. (16362267)
2006
23
Sporadic inclusion-body myositis: a proposed key pathogenetic role of the abnormalities of the ubiquitin-proteasome system, and protein misfolding and aggregation. (16315367)
2005
24
Familial inflammatory inclusion body myositis. (15769920)
2005
25
Immunogenetic differences between Caucasian women with and those without silicone implants in whom myositis develops. (15529361)
2004
26
Expression of lysosome-related proteins and genes in the skeletal muscles of inclusion body myositis. (14513262)
2004
27
Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis. (12667656)
2003
28
An unusual presentation of herpes zoster ophthalmicus: orbital myositis preceding vesicular eruption. (12967827)
2003
29
Myositis ossificans circumscripta of the sacrotuberous ligament: a case report and review of the literature. (12368649)
2002
30
The imaging features of post-traumatic myositis ossificans, with emphasis on MRI. (12475528)
2002
31
Adhesion molecule expression in experimental myositis. (11870719)
2002
32
Bcl-2, Bcl-x, and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases. (11570908)
2001
33
Mycophenolate (CellCept) treatment of myasthenia gravis, chronic inflammatory polyneuropathy and inclusion body myositis. (11311292)
2001
34
Inclusion body myositis associated with systemic lupus erythematosus (SLE) (10833124)
2000
35
The muscle mitogen-activated protein kinase is altered in sporadic inclusion body myositis. (10762511)
2000
36
Prevalence of sporadic inclusion body myositis in Western Australia. (10842277)
2000
37
What's your diagnosis? Fibrodysplasia (myositis) ossificans progressiva. (17322666)
2000
38
Cervical myositis ossificans traumatica: a rare location. (10354880)
1999
39
Controlled studies with high-dose intravenous immunoglobulin in the treatment of dermatomyositis, inclusion body myositis, and polymyositis. (9851729)
1998
40
Myositis ossificans in a young child mimicking monoarthritis of the hip. (19078101)
1996
41
Difference in expression of phosphorylated tau epitopes between sporadic inclusion-body myositis and hereditary inclusion-body myopathies. (8965093)
1996
42
The treatment of inclusion body myositis: a retrospective review and a randomized, prospective trial of immunosuppressive therapy. (8393509)
1993
43
Inclusion body myositis with abundant ring fibers. (1337419)
1992
44
Quantitative morphometric study of muscle in inclusion body myositis. (1335036)
1992
45
Giant cell myocarditis and myositis associated with thymoma and leprosy. (2044017)
1991
46
Myositis ossificans. (2203862)
1990
47
Childhood-type myositis and linear scleroderma. (6683378)
1983
48
Myositis ossificans circumscripta: a benign lesion with a malignant differential diagnosis. (175681)
1976
49
MYOSITIS OSSIFICANS. (14143444)
1964
50
Myositis Ossificans Progressiva. (19994086)
1961

Genetic Variations for Myositis

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Expression for genes affiliated with Myositis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myositis

Search GEO for disease gene expression data for Myositis.

Pathways for genes affiliated with Myositis

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Compounds for genes affiliated with Myositis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1arginine4411.6HLA-B, PSEN1, APP, RPS27A, COX5A, SNCA
2cysteine4411.5RPS27A, SERPINA3, VCAM1, BACE1, COX5A, CAPN3
3creatinine4411.5MME, CAPN3, SERPINA3, COX5A, RPS27A, APP
4h2o24411.5MME, APP, COX5A, MAPT, BACE1, CHKB
5cholesterol44 28 11 2414.4CXCR3, BACE1, CHKB, COX5A, SNCA, HLA-B
6serine4411.4MYOD1, BACE1, COX5A, APP, PSEN1, HLA-B
7alanine4411.4SNCA, PSEN1, APP, VCAM1, PRNP, MYOD1
8retinoic acid44 2412.4SERPINA3, ICAM1, COX5A, RPS27A, APP, PSEN1
9paraffin4411.4RPS27A, HLA-B, SNCA, PRNP, SERPINA3, VCAM1
10tyrosine4411.4CXCR3, PRNP, BACE1, MYOD1, SNCA, CXCL9
11oxygen44 2412.4SERPINA3, MME, MYOD1, BACE1, MSTN, PRNP
12testosterone44 59 11 2414.4MAPT, SNCA, MSTN, VCAM1, HLA-B, APP
13polysaccharide4411.3HLA-B, SERPINA3, VCAM1, BACE1, CHKB, PRNP
14vegf4411.3VCAM1, CHKB, COX5A, RPS27A, ICAM1, APP
15acetylcholine44 49 28 11 2415.3SNCA, SERPINA3, COX5A, MYOD1, MME, RPS27A
16nitric oxide44 11 2413.3HLA-B, CXCL9, CXCR3, COX5A, CHKB, SNCA
17aspartate4411.3BACE1, PSEN1, HLA-B, CHKB, RPS27A, MAPT
18heparin44 28 11 2414.3SERPINA3, PRNP, SNCA, APP, BACE1, MAPT
19superoxide44 2412.3VCAM1, MME, CXCR3, SERPINA3, PSEN1, CHKB
204-hydroxynonenal44 2412.2RPS27A, MME, APP, PSEN1, SNCA, BACE1
21lactacystin4411.2PSEN1, MYOD1, BACE1, SNCA, APP, RPS27A
22calcium44 49 11 2414.2PSEN1, CAPN3, HLA-B, SNCA, SERPINA3, MME
23zinc44 2412.2CHKB, MAPT, MYOD1, MME, SERPINA3, RPS27A
24lactate4411.2ICAM1, MAPT, CHKB, COX5A, HLA-B, MME
25valine4411.2SNCA, PRNP, MAPT, APP, RPS27A, PSEN1
26lysine4411.2PSEN1, RPS27A, SNCA, PRNP, MME, MYOD1
27glutamate4411.2BACE1, APP, PSEN1, SNCA, PRNP, CHKB
28lipid4411.1APP, SERPINA3, VCAM1, MME, BACE1, PRNP
29n acetylcysteine4411.1VCAM1, MAPT, SNCA, CHKB, COX5A, ICAM1
30sodium nitroprusside4411.1VCAM1, MME, CXCL9, CXCR3, COX5A, APP
31dexamethasone44 49 28 1114.1APP, CXCL9, MME, MSTN
32glucose4411.1SNCA, MAPT, SERPINA3, MSTN, CHKB, PSEN1
33formate4411.1RPS27A, APP, SNCA, PRNP, MAPT
34thioflavine s4411.1SNCA, RPS27A, APP, MAPT
35mg 13244 5912.1ICAM1, MAPT, MYOD1, SNCA, CAPN3, RPS27A
36choline44 11 2413.0COX5A, APP, PSEN1, SNCA, CHKB, MAPT
37endotoxin4411.0VCAM1, CXCL9, CXCR3, CHKB, HLA-B, ICAM1
38pge24411.0PRNP, SNCA
39cyclosporin a44 28 5913.0MME, MAPT, HLA-B, CHKB, RPS27A, ICAM1
40guanidine hydrochloride4411.0SERPINA3, CHKB, PRNP, SNCA, RPS27A
41estrogen4411.0MYOD1, BACE1, CHKB
42hydrogen44 2411.9CHKB, MME, BACE1, PSEN1, SNCA, PRNP
43tacrolimus44 49 1112.9RPS27A, CHKB, CXCR3, SNCA
44thioflavin4410.9MAPT, APP, SNCA
45dopamine44 28 11 2413.9MAPT, RPS27A, APP, SNCA, CHKB, MME
46groalpha4410.8CXCL9, VCAM1, CXCR3, ICAM1
47sodium dodecylsulfate4410.7RPS27A, APP, SNCA, PRNP, MAPT
48lysophosphatidylcholine44 2811.7COX5A, VCAM1, CXCL9, ICAM1
49happ4410.5BACE1, MME, APP
50leucine4410.5PSEN1, PRNP, CHKB, BACE1, MYOD1, MME

GO Terms for genes affiliated with Myositis

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16Gene Ontology
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Cellular components related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.1RPS27A, CAPN3, ICAM1, APP, HLA-B, SNCA
2Golgi apparatusGO:00579411.0APP, PSEN1, SNCA, PRNP, BACE1, BACE2
3axonGO:03042411.0MME, MAPT, BACE1, SNCA, PSEN1, APP
4integral to plasma membraneGO:00588710.9ICAM1, APP, PSEN1, HLA-B, BACE1, CXCR3
5cell surfaceGO:00998610.9APP, PSEN1, BACE1, BACE2, VCAM1
6endoplasmic reticulumGO:00578310.7VCAM1, BACE2, BACE1, PRNP, PSEN1
7external side of plasma membraneGO:00989710.7ICAM1, CXCR3, CXCL9, VCAM1
8ciliary rootletGO:03525310.5APP, PSEN1
9growth coneGO:03042610.3MAPT, SNCA, PSEN1

Biological processes related to Myositis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:05043510.9MME, BACE1, PSEN1
2cytokine-mediated signaling pathwayGO:01922110.9VCAM1, HLA-B, ICAM1, RPS27A
3membrane protein ectodomain proteolysisGO:00650910.9PSEN1, BACE1, BACE2
4negative regulation of apoptotic processGO:04306610.9RPS27A, CAPN3, PSEN1, SNCA, PRNP
5smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.8PSEN1, APP
6membrane to membrane dockingGO:02261410.8VCAM1, ICAM1
7interferon-gamma-mediated signaling pathwayGO:06033310.8ICAM1, HLA-B, VCAM1
8response to muscle activityGO:01485010.8CAPN3, MSTN
9positive regulation of receptor recyclingGO:00192110.7SNCA, PSEN1
10axon cargo transportGO:00808810.7MAPT, APP
11cellular copper ion homeostasisGO:00687810.6PRNP, APP
12muscle organ developmentGO:00751710.6CAPN3, MYOD1, MSTN
13response to copper ionGO:04668810.6PRNP, ICAM1
14response to oxidative stressGO:00697910.5PRNP, PSEN1, APP
15regulation of immune responseGO:05077610.3VCAM1, HLA-B, ICAM1

Molecular functions related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:00419010.6BACE2, BACE1, PSEN1

Products for genes affiliated with Myositis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Myositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet