MCID: MYS005
MIFTS: 63

Myositis malady

Neuronal diseases, Rare diseases categories

Summaries for Myositis

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MedlinePlus:32 Myositis means inflammation of the muscles that you use to move your body. an injury, infection, or autoimmune disease can cause it. two specific kinds are polymyositis and dermatomyositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. other symptoms of myositis may include fatigue after walking or standing tripping or falling trouble swallowing or breathing doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. there is no cure for these diseases, but you can treat the symptoms. polymyositis and dermatomyositis are first treated with high doses of a corticosteroid. other options include medications, physical therapy, exercise, heat therapy, assistive devices, and rest. nih: national institute of neurological disorders and stroke

MalaCards based summary: Myositis, also known as inflammatory disorder of muscle, is related to inclusion body myositis and muscular dystrophy, and has symptoms including autosomal dominant inheritance, proximal muscle weakness and myositis. An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and African trypanosomiasis. The drugs carisoprodol and chlorphenesin and the compounds thioflavine s and happ have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are other and nervous system.

Disease Ontology:9 A myopathy characterized by muscle inflammation.

Wikipedia:63 Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely... more...

Aliases & Classifications for Myositis

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Myositis, Aliases & Descriptions:

Name: Myositis 9 11 43 32 60
 
Inflammatory Disorder of Muscle 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:633
NCIt38 C27578
MeSH33 D009220
ICD1025 M60, M60.9, M63.2

Related Diseases for Myositis

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Diseases in the Myositis family:

Bacterial Myositis Viral Myositis

Diseases related to Myositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 374)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis32.2CXCR3, CHKB
2muscular dystrophy30.9CHKB, MSTN, CAPN3
3idiopathic myopathy30.8CHKB, HLA-B
4encephalitis30.7HLA-B, APP, VCAM1
5vasculitis30.7HLA-B, VCAM1, ICAM1
6polymyositis30.5HLA-B, VCAM1, CHKB, PRNP, ICAM1, RPS27A
7meningoencephalitis30.5APP
8arthritis30.5HLA-B, SERPINA3, CXCR3, ICAM1
9limb-girdle muscular dystrophy30.5CAPN3, CHKB
10pneumonia30.4ICAM1, MME
11dermatomyositis30.4HLA-B, SERPINA3, VCAM1, CHKB, PRNP, ICAM1
12myopathy30.3HLA-B, APP, CHKB, PRNP, MSTN, RPS27A
13systemic lupus erythematosus30.3RPS27A, ICAM1, CXCR3, VCAM1
14rheumatoid vasculitis30.3VCAM1, ICAM1
15tauopathy30.2MAPT, RPS27A, APP
16glomerulonephritis30.2VCAM1, MME, ICAM1, RPS27A
17systemic scleroderma30.1ICAM1, MME, VCAM1
18dermatitis30.1ICAM1, CXCR3, VCAM1
19ulcerative colitis29.9HLA-B, CHKB, CXCR3, ICAM1
20graves' disease29.9HLA-B, VCAM1, CXCR3, ICAM1
21uveitis29.9ICAM1, CXCR3, HLA-B
22b-cell lymphomas29.9HLA-B, MME, CXCR3
23ischemia29.8MAPT, ICAM1, CHKB, MME, HLA-B
24hiv-129.8MAPT, MME, HLA-B
25rheumatoid arthritis29.8SERPINA3, VCAM1, MME, CHKB, CXCR3, ICAM1
26leukemia29.7HLA-B, SERPINA3, MME, CXCR3, ICAM1
27neuromuscular disease29.5CHKB, PRNP, MSTN, CAPN3
28multiple system atrophy29.5MAPT, RPS27A, PRNP, SERPINA3
29creutzfeldt-jakob disease29.4APP, SERPINA3, PRNP, RPS27A, MAPT
30stomach cancer29.3HLA-B, SERPINA3, MME, PRNP
31breast cancer29.1HLA-B, MME, CXCR3, RPS27A, MAPT, BACE1
32lung cancer29.0HLA-B, SERPINA3, MME, CXCR3
33amyloidosis28.7HLA-B, APP, SERPINA3, MME, PRNP, RPS27A
34melanoma28.6HLA-B, SERPINA3, VCAM1, MME, CHKB, CXCR3
35alzheimer disease28.5APP, SERPINA3, MME, CHKB, PRNP, CXCR3
36myositis ossificans11.2
37focal myositis10.9
38aphthous stomatitis10.5HLA-B
39neuronal intranuclear inclusion disease10.5RPS27A
40supranuclear palsy, progressive10.5MAPT
41fibrodysplasia ossificans progressiva10.5
42granulomatous myositis10.5
43dementia, lewy body10.5MAPT
44infantile neuroaxonal dystrophy 110.5APP, RPS27A
45pyomyositis10.4
46fasciitis10.4
47dementia10.4APP, MAPT
48frontotemporal lobar degeneration with ubiquitin-positive inclusions10.4RPS27A, MAPT
49bacterial myositis10.4
50niemann-pick disease, type c110.4APP, MAPT

Graphical network of the top 20 diseases related to Myositis:



Diseases related to myositis

Symptoms for Myositis

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HPO human phenotypes related to Myositis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 proximal muscle weakness HP:0003701
3 myositis HP:0100614

Drugs & Therapeutics for Myositis

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Genetic Tests for Myositis

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Anatomical Context for Myositis

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MalaCards organs/tissues related to Myositis:

31
Bone, Testes, Skin, T cells, Skeletal muscle, Lung, Tongue, Brain, B cells, Thyroid, Bone marrow, Lymph node, Heart, Breast, Myeloid, Eye, Spinal cord, Small intestine, Kidney, Ovary, Monocytes, Endothelial, Neutrophil

Animal Models for Myositis or affiliated genes

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MGI Mouse Phenotypes related to Myositis:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.4APP, MME, PRNP, MAPT, BACE1
2MP:00036317.8APP, CHKB, PRNP, ICAM1, MAPT, BACE1
3MP:00053867.7HLA-B, APP, CHKB, PRNP, MSTN, MAPT
4MP:00028737.5APP, PRNP, CXCR3, MAPT, CAPN3, BACE1
5MP:00053697.5APP, CHKB, PRNP, MSTN, ICAM1, MAPT
6MP:00030127.5BACE1, HLA-B, APP, VCAM1, PRNP, MSTN
7MP:00053787.3APP, VCAM1, PRNP, MSTN, ICAM1, MAPT
8MP:00053847.0APP, PRNP, CXCR3, MSTN, ICAM1, MAPT
9MP:00107686.8HLA-B, APP, VCAM1, PRNP, CXCR3, MSTN
10MP:00053876.8HLA-B, APP, VCAM1, MME, PRNP, CXCR3
11MP:00053766.7APP, VCAM1, MME, CHKB, PRNP, CXCR3

Publications for Myositis

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Articles related to Myositis:

(show top 50)    (show all 1698)
idTitleAuthorsYear
1
Myositis as a presenting feature of systemic onset juvenile idiopathic arthritis. (25677488)
2015
2
Orbital myositis in BehAset's disease. (24326194)
2013
3
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
4
Complete Genome Sequence of Encapsulated Haemophilus influenzae Type f KR494, an Invasive Isolate That Caused Necrotizing Myositis. (24092777)
2013
5
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
6
Successful treatment of calcinosis with infliximab in a patient with systemic sclerosis/myositis overlap syndrome. (24255162)
2013
7
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
8
Gemcitabine-induced radiation recall myositis in a patient with dermatomyositis. (24283707)
2013
9
Dengue Viral Myositis Complicated with Rhabdomyolysis and Superinfection of Methicillin-Resistant Staphylococcus aureus. (23476836)
2013
10
Gemcitabine induced myositis in patients with pancreatic cancer: case reports and topic review. (21811892)
2012
11
A case of parosteal osteosarcoma with a rare complication of myositis ossificans. (23194024)
2012
12
Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort. (22884621)
2012
13
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
14
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
15
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
16
Morphoea with myositis: a rare association. (22937437)
2011
17
Vaccination-induced myositis with intramuscular sterile abscess formation. (21479517)
2011
18
Myositis ossificans of the supinator muscle causing posterior interosseous nerve palsy: a case report. (20672400)
2010
19
Dengue myositis and myocarditis. (20739801)
2010
20
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
21
Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies. (19738232)
2009
22
Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease. (19929661)
2009
23
Inclusion body myositis and HIV infection. (18641890)
2008
24
Bilateral and recurrent myositis ossificans in an athlete: a case report and review of treatment options. (16442986)
2006
25
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
26
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
27
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
28
Circumscribed myositis ossificans of the iliopsoas muscle. Description of a case followed-up after 1 and 14 years. (15645792)
2004
29
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
30
Myositis ossificans as a complication of a muscle tendon junction strain of long head of biceps. A case report. (12629466)
2003
31
Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis. (12667656)
2003
32
Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis. (12124873)
2002
33
Recurrent acute myositis after allogeneic bone marrow transplantation for myelodysplasia. (12186701)
2002
34
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
35
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
36
Update on myositis-specific and myositis-associated autoantibodies. (11092195)
2000
37
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
38
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
39
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
40
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
41
Hepatitis C and inclusion body myositis. (8792712)
1996
42
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
43
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
44
Myositis ossificans progressiva: a 10-year follow-up on a patient treated with etidronate disodium. (7734885)
1994
45
Myositis ossificans of medial pterygoid muscle. A cause for temporomandibular joint ankylosis. (1603562)
1992
46
Differential diagnosis of bacterial myositis in AIDS: evaluation with MR imaging. (2027969)
1991
47
Type-I hypersensitivity as a component of eosinophilic myositis (muscular sarcocystosis) in cattle. (2496630)
1989
48
Myositis ossificans. A clinicopathologic study of 21 cases. (3866484)
1985
49
Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically verified case. (5228630)
1967
50
Myositis Ossificans Progressiva. (19994086)
1961

Variations for Myositis

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Expression for genes affiliated with Myositis

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Search GEO for disease gene expression data for Myositis.

Pathways for genes affiliated with Myositis

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Compounds for genes affiliated with Myositis

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Compounds related to Myositis according to GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1thioflavine s4310.1MAPT, RPS27A, APP
2happ439.6APP, MME, BACE1
3chloroquine43 2 49 28 1213.5BACE1, MAPT, RPS27A, APP
4lactacystin439.4APP, RPS27A, MAPT, BACE1
5n acetylcysteine439.3VCAM1, CHKB, ICAM1, RPS27A, MAPT
6simvastatin43 49 59 28 24 1214.2ICAM1, BACE1, CHKB, VCAM1, APP
7formate439.2MAPT, RPS27A, PRNP, APP
84-hydroxynonenal43 2410.1MAPT, BACE1, RPS27A, APP, MME
9tacrolimus43 49 1211.1CXCR3, RPS27A, HLA-B, APP, CHKB
10mg 13243 5910.1ICAM1, RPS27A, MAPT, CAPN3
11sodium dodecylsulfate439.0MAPT, APP, PRNP, RPS27A
12endotoxin439.0HLA-B, ICAM1, VCAM1, CHKB, CXCR3
13fibrinogen439.0ICAM1, HLA-B, SERPINA3, CHKB, VCAM1
14guanidine hydrochloride438.9RPS27A, SERPINA3, CHKB, PRNP
15sodium nitroprusside438.9VCAM1, APP, MME, CXCR3
16actinomycin d438.9MME, ICAM1, RPS27A, APP, MAPT
17formaldehyde43 249.9MAPT, APP, RPS27A, PRNP
18adenylate438.9APP, VCAM1, MME, CHKB, RPS27A, HLA-B
19dopamine43 28 24 1211.7RPS27A, MAPT, CHKB, MME, SERPINA3, APP
20valine438.7RPS27A, MAPT, PRNP, SERPINA3, APP
21cyclosporin a43 28 5910.7HLA-B, MME, CHKB, ICAM1, RPS27A, MAPT
22lactate438.6MAPT, RPS27A, ICAM1, HLA-B, MME, CHKB
23acetylcholine43 49 28 24 1212.6BACE1, MAPT, MME, RPS27A, SERPINA3, APP
24fmlp438.5VCAM1, MME, ICAM1, SERPINA3, CXCR3
25testosterone43 59 24 1211.3RPS27A, CHKB, MSTN, VCAM1, HLA-B, MAPT
26vegf438.3MME, RPS27A, APP, CHKB, ICAM1, VCAM1
27glucose438.2MSTN, CHKB, MAPT, MME, SERPINA3, HLA-B
28nitric oxide43 24 1210.1CXCR3, VCAM1, MME, CHKB, ICAM1, HLA-B
29retinoic acid43 249.1SERPINA3, MAPT, HLA-B, APP, VCAM1, MME
30aspartate438.0MAPT, PRNP, HLA-B, RPS27A, APP, VCAM1
31glutamate438.0MME, APP, MAPT, RPS27A, CHKB, PRNP
32hydrogen43 248.9CHKB, MME, BACE1, RPS27A, PRNP
33alanine437.7MAPT, PRNP, RPS27A, BACE1, CHKB, VCAM1
34cysteine437.6CHKB, MAPT, BACE1, VCAM1, SERPINA3, MME
35estrogen437.6MAPT, BACE1, RPS27A, CXCR3, CHKB, MME
36polysaccharide437.6CHKB, PRNP, BACE1, RPS27A, ICAM1, SERPINA3
37paraffin437.6MAPT, RPS27A, PRNP, CHKB, MME, VCAM1
38creatinine437.5MAPT, RPS27A, CXCR3, CAPN3, MME, SERPINA3
39pge2437.5ICAM1, VCAM1, MME, HLA-B, RPS27A, CXCR3
40lipid437.4HLA-B, APP, SERPINA3, VCAM1, PRNP, BACE1
41zinc43 248.4PRNP, CHKB, MME, SERPINA3, HLA-B, RPS27A
42heparin43 28 24 1210.4MAPT, VCAM1, BACE1, CHKB, PRNP, APP
43h2o2437.4APP, MAPT, RPS27A, ICAM1, PRNP, CHKB
44superoxide43 248.4CXCR3, BACE1, VCAM1, MME, CHKB, PRNP
45cholesterol43 28 24 1210.4PRNP, VCAM1, SERPINA3, HLA-B, CXCR3, BACE1
46dexamethasone43 49 28 1210.2MME, MSTN, HLA-B, APP, SERPINA3, VCAM1
47tyrosine437.1HLA-B, MME, CXCR3, ICAM1, RPS27A, BACE1
48arginine436.8SERPINA3, HLA-B, PRNP, MAPT, VCAM1, MME
49serine436.5BACE1, HLA-B, RPS27A, CXCR3, PRNP, MME
50oxygen43 247.4ICAM1, MSTN, CXCR3, MME, PRNP, CHKB

GO Terms for genes affiliated with Myositis

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Cellular components related to Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.1APP, MME, MAPT, BACE1
2cell surfaceGO:00099869.1HLA-B, APP, VCAM1, BACE1
3external side of plasma membraneGO:00098978.9ICAM1, CXCR3, VCAM1
4Golgi apparatusGO:00057948.7BACE1, PRNP, VCAM1, APP
5integral component of plasma membraneGO:00058878.0HLA-B, APP, MME, CXCR3, ICAM1, BACE1
6extracellular vesicular exosomeGO:00700627.5HLA-B, APP, SERPINA3, MME, PRNP, ICAM1
7plasma membraneGO:00058866.5CAPN3, HLA-B, APP, VCAM1, MME, PRNP

Biological processes related to Myositis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:000808810.2APP, MAPT
2membrane to membrane dockingGO:002261410.1VCAM1, ICAM1
3response to muscle activityGO:00148509.9MSTN, CAPN3
4cellular response to glucose stimulusGO:00713339.8ICAM1, VCAM1
5interferon-gamma-mediated signaling pathwayGO:00603339.8HLA-B, VCAM1, ICAM1
6regulation of immune responseGO:00507769.8ICAM1, VCAM1, HLA-B
7beta-amyloid metabolic processGO:00504359.8MME, BACE1
8response to ethanolGO:00454719.7ICAM1, MSTN, VCAM1
9leukocyte cell-cell adhesionGO:00071599.7VCAM1, ICAM1
10cellular copper ion homeostasisGO:00068789.6APP, PRNP
11positive regulation of NF-kappaB transcription factor activityGO:00510929.6ICAM1, RPS27A, CAPN3
12cytokine-mediated signaling pathwayGO:00192219.6RPS27A, ICAM1, VCAM1, HLA-B
13positive regulation of release of sequestered calcium ion into cytosolGO:00512819.6CAPN3, CXCR3
14heterophilic cell-cell adhesionGO:00071579.5ICAM1, VCAM1
15response to copper ionGO:00466889.5PRNP, ICAM1
16proteolysisGO:00065089.2MME, CAPN3, BACE1
17cell adhesionGO:00071559.1ICAM1, CXCR3, VCAM1, APP
18apoptotic processGO:00069158.9CAPN3, MAPT, RPS27A, CXCR3

Products for genes affiliated with Myositis

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