MCID: MYS005
MIFTS: 70

Myositis malady

Muscle diseases, Neuronal diseases, Rare diseases categories
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Summaries for Myositis

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MedlinePlus:33 Myositis means inflammation of the muscles that you use to move your body. an injury, infection, or autoimmune disease can cause it. two specific kinds are polymyositis and dermatomyositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. other symptoms of myositis may include fatigue after walking or standing tripping or falling trouble swallowing or breathing doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. there is no cure for these diseases, but you can treat the symptoms. polymyositis and dermatomyositis are first treated with high doses of a corticosteroid. other options include medications, physical therapy, exercise, heat therapy, assistive devices, and rest. nih: national institute of neurological disorders and stroke

MalaCards based summary: Myositis, also known as inflammatory disorder of muscle, is related to inclusion body myositis and muscular dystrophy, and has symptoms including An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and African trypanosomiasis. The drugs carisoprodol and chlorphenesin and the compounds thioflavine s and happ have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are other and nervous system.

Disease Ontology:8 A myopathy characterized by muscle inflamation.

Wikipedia:65 Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely... more...

Description from OMIM:46 160750

Aliases & Classifications for Myositis

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Related Diseases for Myositis

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Diseases in the Myositis family:

Bacterial Myositis Viral Myositis

Diseases related to Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 380)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis32.2CXCR3, CHKB
2muscular dystrophy30.9MSTN, CHKB, CAPN3
3idiopathic myopathy30.8HLA-B, CHKB
4encephalitis30.7VCAM1, HLA-B, APP
5vasculitis30.7ICAM1, HLA-B, VCAM1
6polymyositis30.5VCAM1, HLA-B, CHKB, PRNP, ICAM1, RPS27A
7parkinson's disease30.5RPS27A, MAPT
8meningoencephalitis30.5APP
9arthritis30.5ICAM1, CXCR3, SERPINA3, HLA-B
10pneumonia30.4ICAM1, MME
11limb-girdle muscular dystrophy30.4CAPN3, CHKB
12dermatomyositis30.4HLA-B, CHKB, ICAM1, VCAM1, PRNP, SERPINA3
13systemic lupus erythematosus30.3RPS27A, CXCR3, ICAM1, VCAM1
14myopathy30.3RPS27A, APP, PRNP, CHKB, HLA-B, MSTN
15rheumatoid vasculitis30.3ICAM1, VCAM1
16hypertension30.2ICAM1, VCAM1, MME
17tauopathy30.2RPS27A, MAPT, APP
18glomerulonephritis30.2ICAM1, RPS27A, VCAM1, MME
19dermatitis30.1ICAM1, VCAM1, CXCR3
20sarcoidosis30.1ICAM1, CXCR3, SERPINA3
21ulcerative colitis29.9ICAM1, CHKB, HLA-B, CXCR3
22graves' disease29.9HLA-B, VCAM1, ICAM1, CXCR3
23chronic lymphocytic leukemia29.9CXCR3, MME
24systemic scleroderma29.9VCAM1, MME, ICAM1
25uveitis29.9ICAM1, CXCR3, HLA-B
26b-cell lymphomas29.9CXCR3, MME, HLA-B
27ischemia29.8ICAM1, MME, MAPT, HLA-B, CHKB
28rheumatoid arthritis29.8CHKB, SERPINA3, VCAM1, MME, CXCR3, ICAM1
29autoimmune thyroiditis29.7ICAM1, CXCR3, CHKB, HLA-B
30leukemia29.7HLA-B, ICAM1, CXCR3, SERPINA3, MME
31burkitt's lymphoma29.7CXCR3, ICAM1, MME
32neuromuscular disease29.5PRNP, CHKB, MSTN, CAPN3
33multiple system atrophy29.5SERPINA3, RPS27A, MAPT, PRNP
34creutzfeldt-jakob disease29.4MAPT, RPS27A, SERPINA3, APP, PRNP
35stomach cancer29.3HLA-B, SERPINA3, MME, PRNP
36lung cancer29.1MME, SERPINA3, CXCR3, HLA-B
37amyloidosis28.7SERPINA3, PRNP, MME, APP, HLA-B, RPS27A
38alzheimer's disease28.7SERPINA3, BACE1, APP, CHKB, MME, MAPT
39myositis ossificans11.2
40focal myositis10.8
41aphthous stomatitis10.5HLA-B
42neuronal intranuclear inclusion disease10.5RPS27A
43progressive supranuclear palsy10.5MAPT
44fibrodysplasia ossificans progressiva10.5
45lewy body dementia10.5MAPT
46granulomatous myositis10.5
47neuroaxonal dystrophy, infantile10.5APP, RPS27A
48fasciitis10.4
49primary progressive aphasia10.4MAPT, RPS27A
50niemann-pick disease type c110.4MAPT, APP

Graphical network of the top 20 diseases related to Myositis:



Diseases related to myositis

Symptoms for Myositis

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Clinical features from OMIM:

160750

HPO human phenotypes related to Myositis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 proximal muscle weakness HP:0003701
3 myositis HP:0100614

Drugs & Therapeutics for Myositis

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Genetic Tests for Myositis

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Anatomical Context for Myositis

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MalaCards organs/tissues related to Myositis:

32
Bone, Testes, Skin, T cells, Skeletal muscle, Lung, Tongue, Brain, B cells, Thyroid, Bone marrow, Lymph node, Heart, Myeloid, Eye, Spinal cord, Small intestine, Kidney, Breast, Ovary, Monocytes, Endothelial, Neutrophil

Animal Models for Myositis or affiliated genes

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MGI Mouse Phenotypes related to Myositis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.4APP, MME, PRNP, MAPT, BACE1
2MP:00036317.8APP, CHKB, PRNP, ICAM1, MAPT, BACE1
3MP:00053867.7HLA-B, APP, CHKB, PRNP, MSTN, MAPT
4MP:00028737.5APP, PRNP, CXCR3, MAPT, CAPN3, BACE1
5MP:00053697.5APP, CHKB, PRNP, MSTN, ICAM1, MAPT
6MP:00030127.5BACE1, HLA-B, APP, VCAM1, PRNP, MSTN
7MP:00053787.3APP, VCAM1, PRNP, MSTN, ICAM1, MAPT
8MP:00053847.0APP, PRNP, CXCR3, MSTN, ICAM1, MAPT
9MP:00107686.8HLA-B, APP, VCAM1, PRNP, CXCR3, MSTN
10MP:00053876.8HLA-B, APP, VCAM1, MME, PRNP, CXCR3
11MP:00053766.7APP, VCAM1, MME, CHKB, PRNP, CXCR3

Publications for Myositis

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Articles related to Myositis:

(show top 50)    (show all 1661)
idTitleAuthorsYear
1
Orbital myositis in BehAset's disease. (24326194)
2013
2
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
3
Complete Genome Sequence of Encapsulated Haemophilus influenzae Type f KR494, an Invasive Isolate That Caused Necrotizing Myositis. (24092777)
2013
4
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
5
Successful treatment of calcinosis with infliximab in a patient with systemic sclerosis/myositis overlap syndrome. (24255162)
2013
6
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
7
Gemcitabine-induced radiation recall myositis in a patient with dermatomyositis. (24283707)
2013
8
Dengue Viral Myositis Complicated with Rhabdomyolysis and Superinfection of Methicillin-Resistant Staphylococcus aureus. (23476836)
2013
9
Gemcitabine induced myositis in patients with pancreatic cancer: case reports and topic review. (21811892)
2012
10
A case of parosteal osteosarcoma with a rare complication of myositis ossificans. (23194024)
2012
11
Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort. (22884621)
2012
12
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
13
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
14
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
15
Morphoea with myositis: a rare association. (22937437)
2011
16
Vaccination-induced myositis with intramuscular sterile abscess formation. (21479517)
2011
17
Inclusion body myositis: diagnosis, pathogenesis, and treatment options. (21444018)
2011
18
Myositis ossificans of the supinator muscle causing posterior interosseous nerve palsy: a case report. (20672400)
2010
19
Dengue myositis and myocarditis. (20739801)
2010
20
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
21
Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies. (19738232)
2009
22
Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease. (19929661)
2009
23
Inclusion body myositis and HIV infection. (18641890)
2008
24
Bilateral and recurrent myositis ossificans in an athlete: a case report and review of treatment options. (16442986)
2006
25
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
26
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
27
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
28
Circumscribed myositis ossificans of the iliopsoas muscle. Description of a case followed-up after 1 and 14 years. (15645792)
2004
29
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
30
Myositis ossificans as a complication of a muscle tendon junction strain of long head of biceps. A case report. (12629466)
2003
31
Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis. (12667656)
2003
32
Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis. (12124873)
2002
33
Recurrent acute myositis after allogeneic bone marrow transplantation for myelodysplasia. (12186701)
2002
34
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
35
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
36
Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)
2000
37
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
38
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
39
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
40
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
41
Hepatitis C and inclusion body myositis. (8792712)
1996
42
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
43
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
44
Myositis ossificans progressiva: a 10-year follow-up on a patient treated with etidronate disodium. (7734885)
1994
45
Myositis ossificans of medial pterygoid muscle. A cause for temporomandibular joint ankylosis. (1603562)
1992
46
Differential diagnosis of bacterial myositis in AIDS: evaluation with MR imaging. (2027969)
1991
47
Type-I hypersensitivity as a component of eosinophilic myositis (muscular sarcocystosis) in cattle. (2496630)
1989
48
Myositis ossificans. A clinicopathologic study of 21 cases. (3866484)
1985
49
Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically verified case. (5228630)
1967
50
Myositis Ossificans Progressiva. (19994086)
1961

Variations for Myositis

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Expression for genes affiliated with Myositis

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Expression patterns in normal tissues for genes affiliated with Myositis

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Pathways for genes affiliated with Myositis

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Compounds for genes affiliated with Myositis

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Compounds related to Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1thioflavine s4410.1MAPT, RPS27A, APP
2happ449.6APP, MME, BACE1
3chloroquine44 2 50 28 1113.5BACE1, MAPT, RPS27A, APP
4lactacystin449.4APP, RPS27A, MAPT, BACE1
5n acetylcysteine449.3VCAM1, CHKB, ICAM1, RPS27A, MAPT
6simvastatin44 50 61 28 24 1114.2ICAM1, BACE1, CHKB, VCAM1, APP
7formate449.2MAPT, RPS27A, PRNP, APP
84-hydroxynonenal44 2410.1MAPT, BACE1, RPS27A, APP, MME
9tacrolimus44 50 1111.1CXCR3, RPS27A, HLA-B, APP, CHKB
10mg 13244 6110.1ICAM1, RPS27A, MAPT, CAPN3
11sodium dodecylsulfate449.0MAPT, APP, PRNP, RPS27A
12endotoxin449.0HLA-B, ICAM1, VCAM1, CHKB, CXCR3
13fibrinogen449.0ICAM1, HLA-B, SERPINA3, CHKB, VCAM1
14guanidine hydrochloride448.9RPS27A, SERPINA3, CHKB, PRNP
15sodium nitroprusside448.9VCAM1, APP, MME, CXCR3
16actinomycin d448.9MME, ICAM1, RPS27A, APP, MAPT
17formaldehyde44 249.9MAPT, APP, RPS27A, PRNP
18adenylate448.9APP, VCAM1, MME, CHKB, RPS27A, HLA-B
19dopamine44 28 24 1111.7RPS27A, MAPT, CHKB, MME, SERPINA3, APP
20valine448.7RPS27A, MAPT, PRNP, SERPINA3, APP
21cyclosporin a44 28 6110.7HLA-B, MME, CHKB, ICAM1, RPS27A, MAPT
22lactate448.6MAPT, RPS27A, ICAM1, HLA-B, MME, CHKB
23acetylcholine44 50 28 24 1112.6BACE1, MAPT, MME, RPS27A, SERPINA3, APP
24fmlp448.5VCAM1, MME, ICAM1, SERPINA3, CXCR3
25testosterone44 61 24 1111.3RPS27A, CHKB, MSTN, VCAM1, HLA-B, MAPT
26vegf448.3MME, RPS27A, APP, CHKB, ICAM1, VCAM1
27glucose448.2MSTN, CHKB, MAPT, MME, SERPINA3, HLA-B
28nitric oxide44 24 1110.1CXCR3, VCAM1, MME, CHKB, ICAM1, HLA-B
29retinoic acid44 249.1SERPINA3, MAPT, HLA-B, APP, VCAM1, MME
30aspartate448.0MAPT, PRNP, HLA-B, RPS27A, APP, VCAM1
31glutamate448.0MME, APP, MAPT, RPS27A, CHKB, PRNP
32hydrogen44 248.9CHKB, MME, BACE1, RPS27A, PRNP
33alanine447.7MAPT, PRNP, RPS27A, BACE1, CHKB, VCAM1
34cysteine447.6CHKB, MAPT, BACE1, VCAM1, SERPINA3, MME
35estrogen447.6MAPT, BACE1, RPS27A, CXCR3, CHKB, MME
36polysaccharide447.6CHKB, PRNP, BACE1, RPS27A, ICAM1, SERPINA3
37paraffin447.6MAPT, RPS27A, PRNP, CHKB, MME, VCAM1
38creatinine447.5MAPT, RPS27A, CXCR3, CAPN3, MME, SERPINA3
39pge2447.5ICAM1, VCAM1, MME, HLA-B, RPS27A, CXCR3
40lipid447.4HLA-B, APP, SERPINA3, VCAM1, PRNP, BACE1
41zinc44 248.4PRNP, CHKB, MME, SERPINA3, HLA-B, RPS27A
42heparin44 28 24 1110.4MAPT, VCAM1, BACE1, CHKB, PRNP, APP
43h2o2447.4APP, MAPT, RPS27A, ICAM1, PRNP, CHKB
44superoxide44 248.4CXCR3, BACE1, VCAM1, MME, CHKB, PRNP
45cholesterol44 28 24 1110.4PRNP, VCAM1, SERPINA3, HLA-B, CXCR3, BACE1
46dexamethasone44 50 28 1110.2MME, MSTN, HLA-B, APP, SERPINA3, VCAM1
47tyrosine447.1HLA-B, MME, CXCR3, ICAM1, RPS27A, BACE1
48arginine446.8SERPINA3, HLA-B, PRNP, MAPT, VCAM1, MME
49serine446.5BACE1, HLA-B, RPS27A, CXCR3, PRNP, MME
50oxygen44 247.4ICAM1, MSTN, CXCR3, MME, PRNP, CHKB

GO Terms for genes affiliated with Myositis

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Cellular components related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1APP, MME, MAPT, BACE1
2cell surfaceGO:0099869.1APP, VCAM1, BACE1, HLA-B
3external side of plasma membraneGO:0098978.9CXCR3, ICAM1, VCAM1
4Golgi apparatusGO:0057948.7APP, VCAM1, PRNP, BACE1
5integral component of plasma membraneGO:0058878.0APP, CXCR3, HLA-B, ICAM1, MME, BACE1
6extracellular vesicular exosomeGO:0700627.5PRNP, ICAM1, RPS27A, MME, SERPINA3, APP
7plasma membraneGO:0058866.5MME, VCAM1, HLA-B, PRNP, CXCR3, ICAM1

Biological processes related to Myositis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:00808810.2APP, MAPT
2membrane to membrane dockingGO:02261410.1VCAM1, ICAM1
3response to muscle activityGO:0148509.9MSTN, CAPN3
4cellular response to glucose stimulusGO:0713339.8ICAM1, VCAM1
5interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-B, VCAM1, ICAM1
6regulation of immune responseGO:0507769.8ICAM1, VCAM1, HLA-B
7beta-amyloid metabolic processGO:0504359.8MME, BACE1
8response to ethanolGO:0454719.7ICAM1, MSTN, VCAM1
9leukocyte cell-cell adhesionGO:0071599.7VCAM1, ICAM1
10cellular copper ion homeostasisGO:0068789.6APP, PRNP
11positive regulation of NF-kappaB transcription factor activityGO:0510929.6ICAM1, RPS27A, CAPN3
12cytokine-mediated signaling pathwayGO:0192219.6RPS27A, ICAM1, VCAM1, HLA-B
13positive regulation of release of sequestered calcium ion into cytosolGO:0512819.6CAPN3, CXCR3
14heterophilic cell-cell adhesionGO:0071579.5ICAM1, VCAM1
15response to copper ionGO:0466889.5PRNP, ICAM1
16proteolysisGO:0065089.2MME, CAPN3, BACE1
17cell adhesionGO:0071559.1ICAM1, CXCR3, VCAM1, APP
18apoptotic processGO:0069158.9CAPN3, MAPT, RPS27A, CXCR3

Products for genes affiliated with Myositis

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Sources for Myositis

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25ICD10
26ICD10 via Orphanet
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29KEGG
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40NDF-RT
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