MCID: MYS005
MIFTS: 67

Myositis malady

Summaries for Myositis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Myositis means inflammation of the muscles that you use to move your body. an injury, infection, or autoimmune disease can cause it. two specific kinds are polymyositis and dermatomyositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. other symptoms of myositis may include fatigue after walking or standing tripping or falling trouble swallowing or breathing doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. there is no cure for these diseases, but you can treat the symptoms. polymyositis and dermatomyositis are first treated with high doses of a corticosteroid. other options include medications, physical therapy, exercise, heat therapy, assistive devices, and rest. nih: national institute of neurological disorders and stroke

MalaCards: Myositis, also known as inflammatory disorder of muscle, is related to inclusion body myositis and dermatomyositis. An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The drugs carisoprodol and chlorphenesin and the compounds arginine and cysteine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A myopathy characterized by muscle inflamation.

Wikipedia:63 Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely... more...

Description from OMIM:46 160750

Aliases & Classifications for Myositis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt, 25ICD10
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Related Diseases for Myositis

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17GeneCards, 18GeneDecks
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Diseases related to Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis31.7CXCL9, CXCR3, CHKB
2dermatomyositis30.9ICAM1, HLA-B, PRNP, CHKB, VCAM1, SERPINA3
3myopathy30.9COX5A, MSTN, MYOD1, CHKB, PRNP, HLA-B
4arthritis30.6COX5A, ICAM1, HLA-B, CXCR3, CXCL9, SERPINA3
5muscular dystrophy30.5CAPN3, CHKB, MYOD1, MSTN
6influenza30.4CXCL9, CXCR3, HLA-B
7myocarditis30.4CHKB
8rheumatoid arthritis30.3ICAM1, CHKB, CXCR3, CXCL9, MME, VCAM1
9hepatitis30.3HLA-B
10skin disease30.3CXCL9
11alzheimer's disease30.2SNCA, PSEN1, APP, RPS27A, COX5A, PRNP
12neuropathy30.2MSTN, MYOD1, CAPN3
13vasculitis30.2ICAM1, HLA-B, VCAM1
14sarcoma30.2MYOD1
15systemic lupus erythematosus30.2RPS27A, ICAM1, CXCR3, VCAM1
16leukemia30.1ICAM1, HLA-B, CXCR3, MME, SERPINA3
17encephalitis30.1APP, HLA-B, CXCL9, VCAM1
18hepatitis c30.1CXCR3
19brain disease30.0SERPINA3, MAPT, BACE1, PRNP, SNCA, PSEN1
20glomerulonephritis30.0RPS27A, ICAM1, CXCL9, MME, VCAM1
21sarcoidosis30.0SERPINA3, CXCL9, CXCR3, ICAM1
22hypertension30.0VCAM1, MME, ICAM1
23pneumonia30.0MME, ICAM1
24idiopathic myopathy30.0CHKB, HLA-B
25amyloidosis29.9RPS27A, SERPINA3, MME, MAPT, BACE1, PRNP
26ischemia29.9COX5A, ICAM1, PSEN1, HLA-B, SNCA, CHKB
27graves' disease29.9VCAM1, CXCR3, HLA-B, ICAM1
28adenocarcinoma29.8SERPINA3, MME, MAPT, HLA-B
29motor neuron disease29.8MAPT, SNCA, RPS27A, COX5A
30parkinson's disease29.8MAPT, SNCA, RPS27A
31ulcerative colitis29.8ICAM1, HLA-B, CHKB, CXCR3
32duchenne muscular dystrophy29.8CHKB, MYOD1, MSTN
33ankylosing spondylitis29.8HLA-B
34chondrosarcoma29.8SERPINA3
35synovitis29.8VCAM1, ICAM1
36dermatitis29.8ICAM1, CXCR3, CXCL9, VCAM1
37amyotrophic lateral sclerosis29.6RPS27A, CAPN3, APP, PSEN1, SNCA, PRNP
38polymyositis29.6RPS27A, ICAM1, HLA-B, PRNP, CHKB, VCAM1
39tauopathy29.6RPS27A, APP, PSEN1, SNCA, MAPT
40multiple system atrophy29.6RPS27A, SNCA, PRNP, MAPT, SERPINA3
41prion disease29.6MAPT, PRNP, PSEN1, APP
42autoimmune thyroiditis29.6ICAM1, HLA-B, CHKB, CXCR3
43neuromuscular disease29.6CAPN3, PRNP, CHKB, MSTN
44pancreatic cancer29.6SERPINA3, RPS27A, COX5A
45myeloma29.6ICAM1, HLA-B, VCAM1
46burkitt's lymphoma29.6ICAM1, CXCR3, CXCL9, MME
47diabetes mellitus29.6VCAM1, HLA-B, ICAM1
48pheochromocytoma29.6APP, PSEN1, SNCA, BACE1
49hepatocellular carcinoma29.6MME, CXCL9
50uveitis29.6CXCL9, CXCR3, HLA-B, ICAM1

Graphical network of the top 20 diseases related to Myositis:



Diseases related to myositis

Clinical Features for Myositis

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46OMIM
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Clinical features from OMIM:

160750

Drugs & Therapeutics for Myositis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Myositis

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Anatomical Context for Myositis

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32MalaCards
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MalaCards organs/tissues related to Myositis:

32
Bone, Testes, Skin, T cells, Skeletal muscle, Lung, Tongue, Brain, B cells, Thyroid, Bone marrow, Myeloid, Heart, Lymph node, Endothelial, Ovary, Spinal cord, Monocytes, Eye, Breast, Kidney, Small intestine

Animal Models for Myositis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myositis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.4CXCR3, MYOD1, MAPT, BACE2, BACE1, ICAM1
2MP:000538711.2SNCA, PRNP, MAPT, CXCR3, CXCL9, VCAM1
3MP:000536911.2MAPT, MYOD1, BACE1, CHKB, PRNP, PSEN1
4MP:000538411.2ICAM1, VCAM1, MSTN, CXCR3, MAPT, BACE2
5MP:000537811.2SNCA, MSTN, APP, CAPN3, ICAM1, VCAM1
6MP:000537611.1PRNP, SNCA, PSEN1, ICAM1, CAPN3, APP
7MP:000301211.0BACE1, MAPT, PRNP, MYOD1, SNCA, CAPN3
8MP:000363111.0SNCA, PRNP, HLA-B, CHKB, BACE2, MAPT
9MP:000539511.0APP, PSEN1, PRNP, BACE1, MAPT, MME
10MP:000287310.8MAPT, BACE1, PRNP, PSEN1, APP, CAPN3
11MP:000538610.8PRNP, CHKB, SNCA, HLA-B, PSEN1, APP
12MP:001077110.7APP, PSEN1, MME, MAPT, BACE1
13MP:000538510.5CAPN3, PSEN1, VCAM1, MSTN, SNCA, MYOD1

Publications for Myositis

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50PubMed
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Articles related to Myositis:

(show top 50)    (show all 1592)
idTitleAuthorsYear
1
A further patient with parasitic myositis due to Haycocknema perplexum, a rare entity. (23664131)
2013
2
Pulmonary arterial hypertension in antisynthetase syndrome without myositis. (23875599)
2013
3
Myositis in a patient with familial Mediterranean fever and spondyloarthritis successfully treated with anakinra. (23928237)
2013
4
Myositis ossificans of the rotator cuff muscle. (22234372)
2013
5
Lumbar myositis associated with Toxocara spp. infection. (24239450)
2013
6
Longitudinal observational study of sporadic inclusion body myositis: implications for clinical trials. (23489664)
2013
7
Invasive Mycoleptodiscus fungal cellulitis and myositis. (22332907)
2012
8
Myositis ossificans traumatica of the masticatory muscles. (22976727)
2012
9
Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. (18611937)
2011
10
Myositis ossificans traumatica of the neck - a pediatric case. (22205895)
2011
11
Recurrent bilateral orbital myositis: case report and review of the literature. (21575325)
2011
12
Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers--possibly caused by endoplasmic reticulum stress. (20236612)
2010
13
Immunotherapy of myositis: issues, concerns and future prospects. (20125096)
2010
14
Inclusion body myositis: MRC Centre for Neuromuscular Diseases, IBM workshop, London, 13 June 2008. (20074951)
2010
15
Novel therapeutic approaches for inclusion body myositis. (20827206)
2010
16
TREX1 mutations are not associated with sporadic inclusion body myositis. (20192983)
2010
17
Myositis ossificans circumscripta without history of trauma. (21629528)
2010
18
Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage index. (19877055)
2009
19
Use of buccal pad of fat to prevent heterotopic bone formation after excision of myositis ossificans of medial pterygoid muscle. (18571044)
2008
20
Post-traumatic myositis ossificans circumscripta: an unusually large example. (17507534)
2007
21
Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis. (17626287)
2007
22
Myositis ossificans circumscripta of the supra-orbital region: a case report. (18354949)
2007
23
Histoplasmosis as a cause of nodular myositis in an AIDS patient diagnosed on fine needle aspiration cytology. A case report. (17328504)
2007
24
Atypical extraspinal musculoskeletal tuberculosis in immunocompetent patients: part II, tuberculous myositis, tuberculous bursitis, and tuberculous tenosynovites. (17265982)
2006
25
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
26
A case of myositis ossificans as a complication of tetanus treated by surgical excision. (12879713)
2003
27
Usefulness of ultrasonography for early recurrent myositis ossificans. (12665965)
2003
28
Magnetic resonance imaging criteria to differentiate inclusion body myositis from polymyositis. (12913890)
2003
29
Sporadic inclusion body myositis correlates with increased expression and cross-linking by transglutaminases 1 and 2. (10722712)
2000
30
Inclusion body myositis long after dermatomyositis: a report of two cases. (10342053)
1999
31
Myositis ossificans in the neck. (10337511)
1999
32
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
33
Myositis ossificans progressiva: five generations where the disease was exclusively limited to the maxillofacial region. A case report. (9698179)
1998
34
Is myositis ossificans following ARDS a complication of prone-dependency or is it osteoarthropathia hypertrophicans (Bamberger-Marie syndrome)? (9885895)
1998
35
Focal myositis: a polymerase chain reaction analysis for a viral etiology. (9013843)
1997
36
Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis. (9051771)
1996
37
Infectious myositis. A tropical disease steals out of its zone. (8700817)
1996
38
Thallium-201 uptake in myositis ossificans. Potential pitfall in diagnosis. (7750222)
1995
39
Inclusion body myositis and myopathies. (7486861)
1995
40
Myositis ossificans progressiva: a 10-year follow-up on a patient treated with etidronate disodium. (7734885)
1994
41
Fracture through the bone of traumatic myositis ossificans. A report of three cases. (8027150)
1994
42
Flow cytometric study of nodular fasciitis, proliferative fasciitis, and proliferative myositis. (1743699)
1991
43
Focal myositis in the hand. (3351219)
1988
44
Acute orbital myositis mimicking orbital cellulitis. (3389607)
1988
45
Myositis ossificans in the newborn. A case report. (3949841)
1986
46
Resolution of myositis ossificans in a hemophiliac. (4019564)
1985
47
Diagnostic oncology case studies. Heterotopic new bone formation: myositis ossificans versus malignant tumor. (416695)
1978
48
Giant cell myocarditis and myositis. Associated with thymoma and myasthenia gravis. (5822053)
1969
49
Myositis ossificans in the region of the hip-joint. (13651643)
1959
50
Clinicopathologic conference on paravertebral myositis ossificans. (14771025)
1950

Genetic Variations for Myositis

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Expression for genes affiliated with Myositis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myositis

Search GEO for disease gene expression data for Myositis.

Pathways for genes affiliated with Myositis

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Compounds for genes affiliated with Myositis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1arginine4411.6HLA-B, PSEN1, APP, RPS27A, COX5A, SNCA
2cysteine4411.5RPS27A, SERPINA3, VCAM1, BACE1, COX5A, CAPN3
3creatinine4411.5MME, CAPN3, SERPINA3, COX5A, RPS27A, APP
4h2o24411.5MME, APP, COX5A, MAPT, BACE1, CHKB
5cholesterol44 28 11 2414.4CXCR3, BACE1, CHKB, COX5A, SNCA, HLA-B
6serine4411.4MYOD1, BACE1, COX5A, APP, PSEN1, HLA-B
7alanine4411.4SNCA, PSEN1, APP, VCAM1, PRNP, MYOD1
8retinoic acid44 2412.4SERPINA3, ICAM1, COX5A, RPS27A, APP, PSEN1
9paraffin4411.4RPS27A, HLA-B, SNCA, PRNP, SERPINA3, VCAM1
10tyrosine4411.4CXCR3, PRNP, BACE1, MYOD1, SNCA, CXCL9
11oxygen44 2412.4SERPINA3, MME, MYOD1, BACE1, MSTN, PRNP
12testosterone44 59 11 2414.4MAPT, SNCA, MSTN, VCAM1, HLA-B, APP
13polysaccharide4411.3HLA-B, SERPINA3, VCAM1, BACE1, CHKB, PRNP
14vegf4411.3VCAM1, CHKB, COX5A, RPS27A, ICAM1, APP
15acetylcholine44 49 28 11 2415.3SNCA, SERPINA3, COX5A, MYOD1, MME, RPS27A
16nitric oxide44 11 2413.3HLA-B, CXCL9, CXCR3, COX5A, CHKB, SNCA
17aspartate4411.3BACE1, PSEN1, HLA-B, CHKB, RPS27A, MAPT
18heparin44 28 11 2414.3SERPINA3, PRNP, SNCA, APP, BACE1, MAPT
19superoxide44 2412.3VCAM1, MME, CXCR3, SERPINA3, PSEN1, CHKB
204-hydroxynonenal44 2412.2RPS27A, MME, APP, PSEN1, SNCA, BACE1
21lactacystin4411.2PSEN1, MYOD1, BACE1, SNCA, APP, RPS27A
22calcium44 49 11 2414.2PSEN1, CAPN3, HLA-B, SNCA, SERPINA3, MME
23zinc44 2412.2CHKB, MAPT, MYOD1, MME, SERPINA3, RPS27A
24lactate4411.2ICAM1, MAPT, CHKB, COX5A, HLA-B, MME
25valine4411.2SNCA, PRNP, MAPT, APP, RPS27A, PSEN1
26lysine4411.2PSEN1, RPS27A, SNCA, PRNP, MME, MYOD1
27glutamate4411.2BACE1, APP, PSEN1, SNCA, PRNP, CHKB
28lipid4411.1APP, SERPINA3, VCAM1, MME, BACE1, PRNP
29n acetylcysteine4411.1VCAM1, MAPT, SNCA, CHKB, COX5A, ICAM1
30sodium nitroprusside4411.1VCAM1, MME, CXCL9, CXCR3, COX5A, APP
31dexamethasone44 49 28 1114.1APP, CXCL9, MME, MSTN
32glucose4411.1SNCA, MAPT, SERPINA3, MSTN, CHKB, PSEN1
33formate4411.1RPS27A, APP, SNCA, PRNP, MAPT
34thioflavine s4411.1SNCA, RPS27A, APP, MAPT
35mg 13244 5912.1ICAM1, MAPT, MYOD1, SNCA, CAPN3, RPS27A
36choline44 11 2413.0COX5A, APP, PSEN1, SNCA, CHKB, MAPT
37endotoxin4411.0VCAM1, CXCL9, CXCR3, CHKB, HLA-B, ICAM1
38pge24411.0PRNP, SNCA
39cyclosporin a44 28 5913.0MME, MAPT, HLA-B, CHKB, RPS27A, ICAM1
40guanidine hydrochloride4411.0SERPINA3, CHKB, PRNP, SNCA, RPS27A
41estrogen4411.0MYOD1, BACE1, CHKB
42hydrogen44 2411.9CHKB, MME, BACE1, PSEN1, SNCA, PRNP
43tacrolimus44 49 1112.9RPS27A, CHKB, CXCR3, SNCA
44thioflavin4410.9MAPT, APP, SNCA
45dopamine44 28 11 2413.9MAPT, RPS27A, APP, SNCA, CHKB, MME
46groalpha4410.8CXCL9, VCAM1, CXCR3, ICAM1
47sodium dodecylsulfate4410.7RPS27A, APP, SNCA, PRNP, MAPT
48lysophosphatidylcholine44 2811.7COX5A, VCAM1, CXCL9, ICAM1
49happ4410.5BACE1, MME, APP
50leucine4410.5PSEN1, PRNP, CHKB, BACE1, MYOD1, MME

GO Terms for genes affiliated with Myositis

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16Gene Ontology
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Cellular components related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.1VCAM1, APP, MME, CXCR3, MAPT, PRNP
2Golgi apparatusGO:00579411.0BACE2, APP, PSEN1, SNCA, PRNP, BACE1
3axonGO:03042411.0MME, APP, PSEN1, SNCA, BACE1, MAPT
4integral to plasma membraneGO:00588710.9HLA-B, CXCR3, MME, PSEN1, APP, ICAM1
5cell surfaceGO:00998610.9VCAM1, BACE2, BACE1, APP, PSEN1
6endoplasmic reticulumGO:00578310.7PRNP, BACE1, BACE2, VCAM1, PSEN1
7external side of plasma membraneGO:00989710.7ICAM1, CXCR3, CXCL9, VCAM1
8ciliary rootletGO:03525310.5PSEN1, APP
9growth coneGO:03042610.3MAPT, SNCA, PSEN1

Biological processes related to Myositis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:05043510.9MME, BACE1, PSEN1
2cytokine-mediated signaling pathwayGO:01922110.9VCAM1, HLA-B, ICAM1, RPS27A
3membrane protein ectodomain proteolysisGO:00650910.9PSEN1, BACE1, BACE2
4negative regulation of apoptotic processGO:04306610.9RPS27A, CAPN3, PSEN1, SNCA, PRNP
5smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.8PSEN1, APP
6membrane to membrane dockingGO:02261410.8VCAM1, ICAM1
7interferon-gamma-mediated signaling pathwayGO:06033310.8ICAM1, HLA-B, VCAM1
8response to muscle activityGO:01485010.8CAPN3, MSTN
9positive regulation of receptor recyclingGO:00192110.7SNCA, PSEN1
10axon cargo transportGO:00808810.7MAPT, APP
11cellular copper ion homeostasisGO:00687810.6PRNP, APP
12muscle organ developmentGO:00751710.6CAPN3, MYOD1, MSTN
13response to copper ionGO:04668810.6PRNP, ICAM1
14response to oxidative stressGO:00697910.5PRNP, PSEN1, APP
15regulation of immune responseGO:05077610.3VCAM1, HLA-B, ICAM1

Molecular functions related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:00419010.6BACE2, BACE1, PSEN1

Products for genes affiliated with Myositis

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Sources for Myositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet