MCID: MYS005
MIFTS: 61

Myositis malady

Summaries for Myositis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Myositis means inflammation of the muscles that you use to move your body. an injury, infection, or autoimmune disease can cause it. two specific kinds are polymyositis and dermatomyositis. polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. dermatomyositis causes muscle weakness, plus a skin rash. other symptoms of myositis may include fatigue after walking or standing tripping or falling trouble swallowing or breathing doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. there is no cure for these diseases, but you can treat the symptoms. polymyositis and dermatomyositis are first treated with high doses of a corticosteroid. other options include medications, physical therapy, exercise, heat therapy, assistive devices, and rest. nih: national institute of neurological disorders and stroke

MalaCards: Myositis, also known as inflammatory disorder of muscle, is related to inclusion body myositis and polymyositis. An important gene associated with Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The drugs carisoprodol and chlorphenesin and the compounds arginine and cysteine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and immune system.

Disease Ontology:8 A myopathy characterized by muscle inflamation.

Wikipedia:64 Myositis is a general term for inflammation of the muscles. Many such conditions are considered likely... more...

Description from OMIM:47 160750

Aliases & Classifications for Myositis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 47OMIM, 40NCIt, 25ICD10
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Related Diseases for Myositis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis31.7CXCL9, CXCR3, CHKB
2polymyositis31.0CHKB, HLA-B, RPS27A, VCAM1, ICAM1, PRNP
3arthritis30.6HLA-B, SERPINA3, COX5A, CXCR3, CXCL9, ICAM1
4idiopathic myopathy30.3CHKB, HLA-B
5vasculitis30.2HLA-B, VCAM1, ICAM1
6systemic lupus erythematosus30.2VCAM1, RPS27A, CXCR3, ICAM1
7hepatitis b30.1HLA-B
8alzheimer's disease30.0SERPINA3, BACE2, MAPT, MME, BACE1, CHKB
9brain disease30.0MAPT, BACE1, PRNP, SNCA, PSEN1, APP
10amyloidosis29.9SERPINA3, MME, MAPT, BACE1, PRNP, SNCA
11graves' disease29.9ICAM1, HLA-B, CXCR3, VCAM1
12adenocarcinoma29.9SERPINA3, HLA-B, MAPT, MME
13ulcerative colitis29.9CHKB, HLA-B, ICAM1, CXCR3
14duchenne muscular dystrophy29.9MYOD1, CHKB, MSTN
15ankylosing spondylitis29.9HLA-B
16synovitis29.9VCAM1, ICAM1
17hepatitis c29.9CXCR3
18amyotrophic lateral sclerosis29.7MAPT, CHKB, APP, SNCA, PSEN1, CAPN3
19autoimmune thyroiditis29.7CXCR3, CHKB, HLA-B, ICAM1
20parkinson's disease29.7MAPT, SNCA, RPS27A
21pheochromocytoma29.7PSEN1, SNCA, BACE1, APP
22uveitis29.7HLA-B, CXCR3, CXCL9, ICAM1
23sleep disorder29.7CHKB
24nephritis29.7CXCR3, VCAM1
25lateral sclerosis29.7SNCA, MAPT
26rheumatoid vasculitis29.7VCAM1, ICAM1
27stomach cancer29.7SERPINA3, PRNP
28myositis ossificans11.1
29focal myositis10.8
30fibrodysplasia ossificans progressiva10.5
31dysphagia10.4
32overlap myositis10.4
33granulomatous myositis10.3
34myositis fibrosa10.3
35adult dermatomyositis10.3
36pyomyositis10.3
37tetanus10.3
38antisynthetase syndrome10.3
39thymoma10.2
40amyopathic dermatomyositis10.2
41idiopathic eosinophilic myositis10.2
42cellulitis10.2
43giant cell myocarditis10.2
44radiculopathy10.2
45mixed connective tissue disease10.2
46herpes zoster10.2
47bod syndrome10.2
48infective myositis10.2
49spondylitis10.1
50herpes zoster ophthalmicus10.1

Graphical network of the top 20 diseases related to Myositis:



Diseases related to myositis

Clinical Features for Myositis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

160750

Drugs & Therapeutics for Myositis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Myositis

Anatomical Context for Myositis

Animal Models for Myositis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Myositis

Sources:
51PubMed
See all sources

Articles related to Myositis:

(show top 50)    (show all 1593)
idTitleAuthorsYear
1
Orbital myositis in BehAset's disease. (24326194)
2013
2
Inferior rectus myositis: a rare cause of painful ophthalmoplegia and a therapeutic challenge. (22752122)
2013
3
Update in juvenile myositis. (24061078)
2013
4
A rare association of early-onset inclusion body myositis, rheumatoid arthritis and autoimmune thyroiditis: a case report and literature review. (24125563)
2013
5
Asymptomatic hyper-creatine-kinase-emia as sole manifestation of inclusion body myositis. (23888214)
2013
6
Non-traumatic myositis ossificans in the lumbosacral paravertebral muscle. (23908707)
2013
7
Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis. (24040437)
2013
8
Diagnosis and treatment of Sarcocystis neurona-induced myositis in a free-ranging California sea lion. (22256850)
2012
9
Use of cardiac MR imaging to evaluate the presence of myocarditis in autoimmune myositis: three cases. (20049454)
2012
10
A case of systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma associated with hypereosinophilia, granulomatous myositis and vasculitis. (22519739)
2012
11
A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence. (21224040)
2011
12
Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis. (21280003)
2011
13
Focal myositis of the thigh misdiagnosed radiologically as rhabdomyosarcoma. (22700615)
2011
14
Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay. (20724434)
2010
15
Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP). (19639324)
2010
16
Focal myositis of the calf muscles. (19032842)
2008
17
Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (18258695)
2008
18
Histone H1 is released from myonuclei and present in rimmed vacuoles with DNA in inclusion body myositis. (17888663)
2008
19
Treatment of inclusion body myositis with cyclosporin-A or tacrolimus: successful long-term management in patients with earlier active disease and concomitant autoimmune features. (17543149)
2007
20
Myositis ossificans of the abdominal rectus muscle: report of a case. (16794797)
2006
21
Tc-99m MDP bone scintigraphy of myositis as a manifestation of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation. (15770972)
2005
22
Circumscribed myositis ossificans of the iliopsoas muscle. Description of a case followed-up after 1 and 14 years. (15645792)
2004
23
Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle. (14705121)
2004
24
Inclusion body myositis evolving in systemic lupus erythrematosus? A case report. (12869675)
2003
25
Myositis ossificans and fibroosseous pseudotumor of digits: a clinicopathological review of 64 cases with emphasis on diagnostic pitfalls. (12894350)
2003
26
Intravenous immunoglobulin for dysphagia of inclusion body myositis. (11805271)
2002
27
Prevalence in myositis of antibodies recognizing anti-U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin. (11703380)
2001
28
Radiologic case study. Traumatic myositis ossificans. (10535566)
1999
29
Dysphagia in patients with inclusion body myositis. (10507903)
1999
30
Inclusion body myositis. (10590889)
1999
31
Inclusion body myositis in twins. (10449152)
1999
32
Chondrosarcoma and myositis ossificans. (9868636)
1998
33
Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: diseases of oxidative stress and aging? (9678308)
1998
34
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
35
Generalized periarticular myositis ossificans as a complication of pharmacologically induced paralysis. (7570166)
1995
36
Atypical arteriographic features of myositis ossificans circumscripta (MOC). (1410563)
1992
37
Early myositis ossificans: a new echographic sign. (3072145)
1988
38
Tartrate-resistant acid phosphatase containing cells in nodular fasciitis, proliferative fasciitis, and proliferative myositis. (3059723)
1988
39
Focal myositis and elevated creatine kinase levels in a patient with phaeochromocytoma. (3714605)
1986
40
Myositis ossificans of the upper extremity: a long-term follow-up. (6511895)
1984
41
Myositis ossificans localisata as a complication of tetanus. (525320)
1979
42
Myositis ossificans progressiva (a case report). (1024095)
1976
43
The subcutaneous fascial analogue of myositis proliferans: electron microscopic examination of two cases and comparison with myositis ossificans localisata. (128892)
1975
44
Myositis ossificans progressiva. (Case report). (4793483)
1973
45
Juxtacortical circumscribed myositis ossificans: evolution and radiographic features. (5431413)
1970
46
Myositis ossificans progressiva. A report of two cases with chromosome studies. (5685891)
1968
47
Radiological case of the month. Progressive myositis ossificans. (5697195)
1968
48
MYOSITIS OSSIFICANS PROGRESSIVA. MINERAL, METABOLIC AND RADIOACTIVE CALCIUM STUDIES OF THE EFFECTS OF HORMONES. (14206759)
1964
49
Myositis ossificans progressiva. (Report of a case). (14407801)
1959
50
Traumatic proliferations of fibrocartilage with ossification in the genesis of spondylitis deformans and myositis ossificans. (20273209)
1947

Genetic Variations for Myositis

Expression for genes affiliated with Myositis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myositis

Search GEO for disease gene expression data for Myositis.

Pathways for genes affiliated with Myositis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 53R&D Systems
See all sources

Compounds for genes affiliated with Myositis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1arginine4511.6HLA-B, PSEN1, APP, RPS27A, COX5A, SNCA
2cysteine4511.5RPS27A, SERPINA3, VCAM1, BACE1, COX5A, CAPN3
3creatinine4511.5MME, CAPN3, SERPINA3, COX5A, RPS27A, APP
4h2o24511.5MME, APP, COX5A, MAPT, BACE1, CHKB
5cholesterol45 29 11 2414.4CXCR3, BACE1, CHKB, COX5A, SNCA, HLA-B
6serine4511.4MYOD1, BACE1, COX5A, APP, PSEN1, HLA-B
7alanine4511.4SNCA, PSEN1, APP, VCAM1, PRNP, MYOD1
8retinoic acid45 2412.4SERPINA3, ICAM1, COX5A, RPS27A, APP, PSEN1
9paraffin4511.4RPS27A, HLA-B, SNCA, PRNP, SERPINA3, VCAM1
10tyrosine4511.4CXCR3, PRNP, BACE1, MYOD1, SNCA, CXCL9
11oxygen45 2412.4SERPINA3, MME, MYOD1, BACE1, MSTN, PRNP
12testosterone45 60 11 2414.4MAPT, SNCA, MSTN, VCAM1, HLA-B, APP
13polysaccharide4511.3HLA-B, SERPINA3, VCAM1, BACE1, CHKB, PRNP
14vegf4511.3VCAM1, CHKB, COX5A, RPS27A, ICAM1, APP
15acetylcholine45 50 29 11 2415.3SNCA, SERPINA3, COX5A, MYOD1, MME, RPS27A
16nitric oxide45 11 2413.3HLA-B, CXCL9, CXCR3, COX5A, CHKB, SNCA
17aspartate4511.3BACE1, PSEN1, HLA-B, CHKB, RPS27A, MAPT
18heparin45 29 11 2414.3SERPINA3, PRNP, SNCA, APP, BACE1, MAPT
19superoxide45 2412.3VCAM1, MME, CXCR3, SERPINA3, PSEN1, CHKB
204-hydroxynonenal45 2412.2RPS27A, MME, APP, PSEN1, SNCA, BACE1
21lactacystin4511.2PSEN1, MYOD1, BACE1, SNCA, APP, RPS27A
22calcium45 50 11 2414.2PSEN1, CAPN3, HLA-B, SNCA, SERPINA3, MME
23zinc45 2412.2CHKB, MAPT, MYOD1, MME, SERPINA3, RPS27A
24lactate4511.2ICAM1, MAPT, CHKB, COX5A, HLA-B, MME
25valine4511.2SNCA, PRNP, MAPT, APP, RPS27A, PSEN1
26lysine4511.2PSEN1, RPS27A, SNCA, PRNP, MME, MYOD1
27glutamate4511.2BACE1, APP, PSEN1, SNCA, PRNP, CHKB
28lipid4511.1APP, SERPINA3, VCAM1, MME, BACE1, PRNP
29n acetylcysteine4511.1VCAM1, MAPT, SNCA, CHKB, COX5A, ICAM1
30sodium nitroprusside4511.1VCAM1, MME, CXCL9, CXCR3, COX5A, APP
31dexamethasone45 50 29 1114.1APP, CXCL9, MME, MSTN
32glucose4511.1SNCA, MAPT, SERPINA3, MSTN, CHKB, PSEN1
33formate4511.1RPS27A, APP, SNCA, PRNP, MAPT
34thioflavine s4511.1SNCA, RPS27A, APP, MAPT
35mg 13245 6012.1ICAM1, MAPT, MYOD1, SNCA, CAPN3, RPS27A
36choline45 11 2413.0COX5A, APP, PSEN1, SNCA, CHKB, MAPT
37endotoxin4511.0VCAM1, CXCL9, CXCR3, CHKB, HLA-B, ICAM1
38pge24511.0PRNP, SNCA
39cyclosporin a45 29 6013.0MME, MAPT, HLA-B, CHKB, RPS27A, ICAM1
40guanidine hydrochloride4511.0SERPINA3, CHKB, PRNP, SNCA, RPS27A
41estrogen4511.0MYOD1, BACE1, CHKB
42hydrogen45 2411.9CHKB, MME, BACE1, PSEN1, SNCA, PRNP
43tacrolimus45 50 1112.9RPS27A, CHKB, CXCR3, SNCA
44thioflavin4510.9MAPT, APP, SNCA
45dopamine45 29 11 2413.9MAPT, RPS27A, APP, SNCA, CHKB, MME
46groalpha4510.8CXCL9, VCAM1, CXCR3, ICAM1
47sodium dodecylsulfate4510.7RPS27A, APP, SNCA, PRNP, MAPT
48lysophosphatidylcholine45 2911.7COX5A, VCAM1, CXCL9, ICAM1
49happ4510.5BACE1, MME, APP
50leucine4510.5PSEN1, PRNP, CHKB, BACE1, MYOD1, MME

GO Terms for genes affiliated with Myositis

Sources:
16Gene Ontology
See all sources

Cellular components related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.1VCAM1, APP, MME, CXCR3, MAPT, PRNP
2Golgi apparatusGO:00579411.0BACE2, APP, PSEN1, SNCA, PRNP, BACE1
3axonGO:03042411.0MME, APP, PSEN1, SNCA, BACE1, MAPT
4integral to plasma membraneGO:00588710.9HLA-B, CXCR3, MME, PSEN1, APP, ICAM1
5cell surfaceGO:00998610.9VCAM1, BACE2, BACE1, APP, PSEN1
6endoplasmic reticulumGO:00578310.7PRNP, BACE1, BACE2, VCAM1, PSEN1
7external side of plasma membraneGO:00989710.7ICAM1, CXCR3, CXCL9, VCAM1
8ciliary rootletGO:03525310.5PSEN1, APP
9growth coneGO:03042610.3MAPT, SNCA, PSEN1

Biological processes related to Myositis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:05043510.9BACE1, MME, PSEN1
2cytokine-mediated signaling pathwayGO:01922110.9VCAM1, ICAM1, HLA-B, RPS27A
3membrane protein ectodomain proteolysisGO:00650910.9BACE2, BACE1, PSEN1
4negative regulation of apoptotic processGO:04306610.9SNCA, RPS27A, PRNP, CAPN3, PSEN1
5smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.8PSEN1, APP
6membrane to membrane dockingGO:02261410.8ICAM1, VCAM1
7interferon-gamma-mediated signaling pathwayGO:06033310.8ICAM1, VCAM1, HLA-B
8response to muscle activityGO:01485010.8CAPN3, MSTN
9positive regulation of receptor recyclingGO:00192110.7SNCA, PSEN1
10axon cargo transportGO:00808810.7APP, MAPT
11cellular copper ion homeostasisGO:00687810.6APP, PRNP
12muscle organ developmentGO:00751710.6MSTN, CAPN3, MYOD1
13response to copper ionGO:04668810.6ICAM1, PRNP
14response to oxidative stressGO:00697910.5APP, PRNP, PSEN1
15regulation of immune responseGO:05077610.3HLA-B, VCAM1, ICAM1

Molecular functions related to Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aspartic-type endopeptidase activityGO:00419010.6BACE2, BACE1, PSEN1

Products for genes affiliated with Myositis

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  • Antibodies

Sources for Myositis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet