MCID: MYS001
MIFTS: 37

Myositis Ossificans malady

Categories: Muscle diseases

Aliases & Classifications for Myositis Ossificans

Aliases & Descriptions for Myositis Ossificans:

Name: Myositis Ossificans 12 14 69
Ossification - Muscle 12
Myisitis Ossificans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:668
MeSH 42 D009221
NCIt 47 C3253
UMLS 69 C0027122

Summaries for Myositis Ossificans

Disease Ontology : 12 A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.

MalaCards based summary : Myositis Ossificans, also known as ossification - muscle, is related to fibrodysplasia ossificans progressiva and myositis. An important gene associated with Myositis Ossificans is BMP1 (Bone Morphogenetic Protein 1), and among its related pathways/superpathways are TGF-beta signaling pathway (KEGG) and TGF-beta Receptor Signaling (WikiPathways). The drug Tretinoin has been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and bone marrow, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : 71 Myositis ossificans comprises two syndromes characterized by heterotopic ossification (calcification) of... more...

Related Diseases for Myositis Ossificans

Diseases related to Myositis Ossificans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 12.1
2 myositis 11.1
3 osseous heteroplasia, progressive 11.1
4 tetanus 10.2
5 sarcoma 10.1
6 cervicitis 10.1
7 post-traumatic stress disorder 10.0 BMP1 GALNT3
8 poliomyelitis 10.0
9 spondylitis 10.0
10 aneurysmal bone cysts 9.9
11 ankylosis 9.9
12 aneurysm 9.9
13 cherubism 9.9
14 chondrosarcoma 9.9
15 dermatomyositis 9.9
16 ischemia 9.9
17 compartment syndrome 9.9
18 periostitis 9.9
19 hemophilia 9.9
20 aplastic anemia 9.7
21 niemann-pick disease, type b 9.7
22 pick disease 9.7
23 rubinstein-taybi syndrome 9.7
24 alveolar soft-part sarcoma 9.7
25 lipoma 9.7
26 radioulnar synostosis 9.7
27 arthritis 9.7
28 cerebral palsy 9.7
29 leukemia 9.7
30 niemann-pick disease 9.7
31 spinal cord injury 9.7
32 lymphoma 9.7
33 thrombosis 9.7
34 fibrous dysplasia 9.7
35 spindle cell lipoma 9.7
36 osteomalacia 9.7
37 hypoparathyroidism 9.7
38 esophagitis 9.7
39 synostosis 9.7
40 adenocarcinoma 9.7
41 purpura 9.7
42 cerebritis 9.7
43 laryngitis 9.7
44 plexopathy 9.7
45 pseudohypoparathyroidism 9.7
46 clear cell chondrosarcoma 9.7
47 fibroosseous pseudotumor of digits 9.7
48 neuropathy 9.7
49 piriformis syndrome 9.7
50 polymyositis 9.7

Graphical network of the top 20 diseases related to Myositis Ossificans:



Diseases related to Myositis Ossificans

Symptoms & Phenotypes for Myositis Ossificans

MGI Mouse Phenotypes related to Myositis Ossificans:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.46 BMP1 BMP4 FOS GALNT3
2 limbs/digits/tail MP:0005371 9.26 BMP1 BMP4 FOS GALNT3
3 skeleton MP:0005390 9.02 ASPA BMP1 BMP4 FOS GALNT3

Drugs & Therapeutics for Myositis Ossificans

Drugs for Myositis Ossificans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538

Interventional clinical trials:


id Name Status NCT ID Phase
1 An Open-Label Extension Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects Active, not recruiting NCT02279095 Phase 2
2 An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects Active, not recruiting NCT02190747 Phase 2
3 An Open-Label Extension Study of Palovarotene to Prevent Heterotopic Ossification in FOP Subjects in France Active, not recruiting NCT02979769 Phase 2
4 In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects Suspended NCT02521792 Phase 2
5 Urine Sample Collection From FOP Patients Completed NCT02066324
6 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
7 A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP) Active, not recruiting NCT02322255
8 Discovering the Gene(s) Causing Developmental Dysplasia of the Hip (DDH) Active, not recruiting NCT01193673

Search NIH Clinical Center for Myositis Ossificans

Genetic Tests for Myositis Ossificans

Anatomical Context for Myositis Ossificans

MalaCards organs/tissues related to Myositis Ossificans:

39
Bone, Lymph Node, Bone Marrow, Breast, Brain, Ovary, Spinal Cord

Publications for Myositis Ossificans

Articles related to Myositis Ossificans:

(show top 50) (show all 547)
id Title Authors Year
1
Intra-abdominal myositis ossificans in an asymptomatic patient during closure of a Hartmann's colostomy. ( 27887014 )
2016
2
A rare case of pediatric Nontraumatic Myositis Ossificans in the posterior triangle. ( 27063765 )
2016
3
Myositis ossificans traumatica (circumscripta) and return to sport: A retrospective series of 19 cases. ( 26934992 )
2016
4
Myositis ossificans of the platysma mimicking a malignancy: a case report with review of the literature. ( 26904497 )
2016
5
Myositis ossificans: A rare location in the foot. Report of a case and review of literature. ( 27474831 )
2016
6
Posttraumatic myositis ossificans of the hand : A locally aggressive malignancy-mimicking tumor. ( 27048331 )
2016
7
Myositis ossificans after navigated knee surgery: A report of two cases and literature review. ( 26993571 )
2016
8
Nontraumatic Myositis Ossificans of Hip: A Case Presentation. ( 27437157 )
2016
9
Poster 92 Identifying Nonhereditary Myositis Ossificans Traumaticus in a Community Hospital. ( 27672859 )
2016
10
Myositis ossificans of the longus coli muscle following cervical spine fracture-dislocation. ( 27077572 )
2016
11
Synovial Sarcoma Mimicking Myositis Ossificans. ( 27595081 )
2016
12
MR imaging and ultrasonography findings of early myositis ossificans: a case report. ( 27511030 )
2016
13
(18)F-fluorodeoxyglucose-positron emission tomography avid paraspinal soft-tissue mass mimicking a malign neoplasm: non-traumatic myositis ossificans. ( 27001110 )
2016
14
Myositis ossificans progressive: case report. ( 27800117 )
2016
15
Non-traumatic myositis ossificans circumscripta at elbow joint in a 9-year old child. ( 27140223 )
2016
16
Myositis Ossificans Associated with Prayer Mark. ( 27107753 )
2016
17
MYOSITIS OSSIFICANS TRAUMATICA IN A VAMPIRE BAT (DESMODUS ROTUNDUS). ( 27691970 )
2016
18
Pre-surgical CT-assessment of neurogenic myositis ossificans of the hip and risk factors of recurrence: a series of 101 consecutive patients. ( 27756329 )
2016
19
Myositis ossificans of the masseter muscle: A rare location. Report of a case and review of literature. ( 27034763 )
2016
20
Clinicopathologic Assessment of Myositis Ossificans Circumscripta of the Masseter Muscles. ( 26147032 )
2015
21
A Rare Metastatic Myositis Ossificans of Obturator Muscle Secondary to Urothelial Carcinoma. ( 26500729 )
2015
22
Post-infectious myositis ossificans in medial, lateral pterygoid muscles: A case report and review of the literature. ( 25621069 )
2015
23
Myositis Ossificans. ( 26320160 )
2015
24
Pediatric myositis ossificans mimicking osteosarcoma. ( 26508182 )
2015
25
Avulsion Fracture and Myositis Ossificans in a Professional Teenage Dancer: A Case Report. ( 26046617 )
2015
26
Myositis ossificans traumatica of the medial pterygoid muscle following a third molar extraction. ( 25487562 )
2015
27
Myositis ossificans of the quadriceps femoris in a soccer player. ( 26264943 )
2015
28
Myositis Ossificans in the Thigh of a Lacrosse Player. ( 26313164 )
2015
29
Atraumatic Myositis Ossificans of Iliopsoas Excised through an ASIS Osteotomy Case Report and Description of a Novel Technique. ( 26517003 )
2015
30
The stone women-Myositis ossificans Progressiva. ( 27299087 )
2015
31
Myositis Ossificans of Rectus Femoris: A Rare Case Report. ( 27299083 )
2015
32
An Unusual Presentation of Myositis Ossificans in a Pediatric Patient. ( 26491916 )
2015
33
Adult Niemann-Pick disease type B with myositis ossificans: a case report. ( 26338042 )
2015
34
Myositis ossificans on the forearm in a 10-year-old girl. ( 25647566 )
2015
35
A Rare Case Of Non Traumatic Myositis Ossificans Circumscripta. ( 27299058 )
2015
36
Myositis ossificans circumscripta. ( 26215631 )
2015
37
Myositis Ossificans of the Temporalis Muscle. ( 26703385 )
2015
38
Delayed Sciatic Nerve Injury Resulting from Myositis Ossificans Traumatica. ( 26548968 )
2015
39
Myositis ossificans occupying the thenar region: a case report. ( 25943356 )
2015
40
Myositis Ossificans Circumscripta in the Masseter Muscle Mimicking Phleboliths. ( 26147036 )
2015
41
Myositis ossificans of the serratus anterior as a rare complication of massage: a case report. ( 26077883 )
2015
42
A case of malignant transformation of myositis ossificans. ( 24490190 )
2014
43
Computed tomography in the diagnosis of myositis ossificans - case report. ( 25210536 )
2014
44
Operative management of idiophatic myositis ossificans of lateral pterygoid muscle. ( 25290385 )
2014
45
Myositis ossificans traumatica causing ankylosis of the elbow. ( 25436075 )
2014
46
Bilateral deltoid myositis ossificans in a weightlifter using anabolic steroids. ( 25350630 )
2014
47
Surgical Treatment of Traumatic Myositis Ossificans of the Extensor Carpi Radialis Muscle in a Dog. ( 25330281 )
2014
48
Non-traumatic myositis ossificans circumscripta: AA diagnosis trap. ( 25983509 )
2014
49
Myositis ossificans of the left medial pterygoid muscle: case report and review of the literature of myositis ossificans of masticatory muscles. ( 24624256 )
2014
50
Traumatic myositis ossificans of the masseter muscle: a case report with conventional and advanced imaging features. ( 25184723 )
2014

Variations for Myositis Ossificans

Expression for Myositis Ossificans

Search GEO for disease gene expression data for Myositis Ossificans.

Pathways for Myositis Ossificans

Pathways related to Myositis Ossificans according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.18 ACVR1C BMP4
2 10.92 BMP4 FOS
3 10.68 BMP1 BMP4
4 10.53 BMP1 BMP4 FOS

GO Terms for Myositis Ossificans

Biological processes related to Myositis Ossificans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.32 BMP1 BMP4
2 cartilage development GO:0051216 9.26 BMP1 BMP4
3 SMAD protein signal transduction GO:0060395 9.16 BMP4 FOS
4 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 8.96 BMP4 FOS
5 positive regulation of cartilage development GO:0061036 8.62 BMP1 BMP4

Sources for Myositis Ossificans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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