Myotonic Dystrophy Type 1 malady

NIH Rare Diseases: Myotonic dystrophy type 1, one of the two types of myotonic dystrophy, is an inherited type of muscular dystrophy that affects the muscles and other body systems (e.g., heart, eyes, pancreas).  Myotonic dystrophy type 1 has been categorized into three somewhat overlapping subtypes: mild, classic, and congenital (present at birth). Symptoms of the mild form are the least severe with a normal life span. The classic form is characterized by muscle weakness and wasting, prolonged muscle tensing (myotonia), cataract, and often abnormal heart function; adults may become physically disabled and may have a shortened life span. The congenital form is characterized by severe generalized weakeness at birth (hypotonia), often causing complications with breathing and early death. The condition is inherited in an autosomal dominant pattern and is caused by mutations in the DMPK gene. ³⁰

MalaCards: Myotonic Dystrophy Type 1, also known as DM1, is related to myotonic dystrophy type 2 and congenital myotonic dystrophy. An important gene associated with Myotonic Dystrophy Type 1 is CELF1 (CUGBP, Elav-like family member 1), and among its related pathways are Platelet calcium homeostasis and Calcium Mediated T-Cell Apoptosis. The compounds sb 408124 and sb 334867 have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are integument and nervous system.

GeneReviews summary for myotonic-d

myotonic dystrophy type 1 44 15 30 16 dm1 44 30 16 steinert's disease 15 30 steinert disease 30 16 myotonic muscular dystrophy type 1 16

dystrophia myotonica type 1 30 steinert myotonic dystrophy 30 dystrophia myotonica 1 43 myotonic dystrophy 43

Disease types for myotonic dystrophy family:

myotonic dystrophy type 1	myotonic dystrophy type 2

Diseases related to myotonic dystrophy type 1 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 205)

id	Related Disease	Score	Top Affiliating Genes
1	myotonic dystrophy type 2	38.0	CNBP, CLCN1, DMPK
2	congenital myotonic dystrophy	34.9	DMPK, SIX5
3	myotonia	31.4	CNBP, CLCN1, MBNL1, DM1, DMPK
4	spinal-bulbar muscular atrophy	29.9	ATXN1, AR, DMPK
5	muscular dystrophy	29.5	CNBP, CLCN1, KCNN1, KCNN3, CELF1, ATP2A1
6	hypogonadism	29.4	CLCN1, AR, INSR, MBNL1, TNF, DMPK
7	cholelithiasis	29.3	CD40LG, AR, MBNL1, ADIPOQ
8	myasthenia gravis	28.6	CD40LG, AR, TNF, DMPK, RYR1
9	sleep disorder	28.0	CNBP, TNF, HCRT, HCRTR1, HCRTR2, ADIPOQ
10	hypertrophic cardiomyopathy	28.0	ATP2A2, AR, TNF, DMPK, ADIPOQ
11	muscular atrophy	28.0	ATXN1, AR, MBNL1, DMPK, SOD1, RYR1
12	huntington's disease	27.8	ATXN1, AR, MAPT, HCRT, SOD1
13	cataract	27.2	CNBP, CLCN1, ATP2A3, ATP2A1, ATP2A2, MBNL1
14	myotonic dystrophy	27.1	CNBP, MYOM1, CLCN1, KCNN1, KCNN3, MTMR1
15	glucose intolerance	27.1	INSR, TNF, SOD1, ADIPOQ
16	hypoglycemia	26.9	INSR, HSPA5, TNF, HCRT, SOD1
17	type 1 diabetes mellitus	26.3	CD40LG, AR, INSR, TNF, SOD1, ADIPOQ
18	dementia	25.9	CNBP, ATXN1, INSR, MAPT, TNF, HCRT
19	blindness	25.6	CNBP, CDKN2A, CD40LG, AR, MAPT, TNF
20	ataxia	25.0	KCNN1, KCNN3, ATXN1, AR, MAPT, HSPA5
21	diabetes mellitus	25.0	ATP2A3, ATP2A2, CDKN2A, CD40LG, AR, INSR
22	insulin resistance	24.4	CNBP, CELF1, CD40LG, AR, INSR, HSPA5
23	hyperglycemia	24.1	CD40LG, INSR, HSPA5, TNF, SOD1, ADIPOQ
24	diabetic retinopathy	24.1	CD40LG, AR, INSR, TNF, SOD1, ADIPOQ
25	myopathy	24.1	CNBP, CLCN1, MTMR1, ATP2A1, CD40LG, AR
26	obesity	24.0	ATP2A1, CDKN2A, AR, INSR, TNF, HCRT
27	neuropathy	23.3	ATXN1, CD40LG, AR, MAPT, TNF, DMPK
28	type 2 diabetes mellitus	23.3	ATP2A3, ATP2A2, CDKN2A, AR, INSR, TNF
29	fibrosis	22.7	CLCN1, ATP2A3, ATP2A2, CDKN2A, CD40LG, HSPA5
30	colon cancer	22.4	CNBP, CDKN2A, CD40LG, AR, HSPA5, TNF
31	neuronitis	21.9	CLCN1, KCNN1, KCNN3, ATP2A3, ATXN1, CDKN2A
32	thyroiditis	21.4	ATP2A3, ATP2A1, ATP2A2, ATXN1, CDKN2A, CD40LG
33	cholesterol	21.1	CNBP, ATP2A2, CDKN2A, CD40LG, AR, INSR
34	adenocarcinoma	21.0	ATP2A3, CDKN2A, CD40LG, MIR206, AR, INSR
35	alzheimer's disease	19.6	KCNN1, ATP2A3, ATP2A1, ATP2A2, ATXN1, CDKN2A
36	myotonic disease	13.7	CLCN1, DMPK
37	thomsen disease	13.5	CNBP, CLCN1
38	adrenal adenoma	13.2	HCRT, HCRTR1, HCRTR2
39	normal pressure hydrocephalus	13.2	MAPT, HCRT
40	obesity, resistance to	13.1	HCRTR1, HCRTR2
41	congenital fiber-type disproportion	13.0	INSR, RYR1
42	neuromuscular disease	13.0	AR, DMPK, RYR1
43	migraine without aura	13.0	KCNN1, KCNN3, TNF
44	muscle disorders	13.0	CLCN1, MAPT, RYR1
45	centronuclear myopathy	13.0	MTMR1, INSR, RYR1
46	alzheimer disease type 3	12.9	INSR, MAPT
47	x-linked spinal-bulbar muscle atrophy	12.8	AR, SOD1
48	bipolar affective disorder	12.8	KCNN1, KCNN3, ATP2A2, TNF
49	albinism	12.7	AR, HCRT, HCRTR1, HCRTR2
50	metabolic syndrome x	12.7	INSR, TNF, ADIPOQ

Approved drugs:

Drug clinical trials:

Genetic tests related to myotonic dystrophy type 1:

id	Genetic test	Affiliating Genes
1	Myotonic Dystrophy Type 1 clinical/research	DM1, DMPK

MalaCards organs/tissues related to myotonic dystrophy type 1:

²²

MGI Mouse Phenotypes related to myotonic dystrophy type 1:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	8.9	MAPT, RYR1, ATP2A2, HSPA5, CLCN1
2	nervous system phenotype	MP:0003631	8.5	CLCN1, INSR, KCNN1, KCNN3, ATXN1, DTNA
3	tumorigenesis	MP:0002006	7.5	ADIPOQ, TNF, HSPA5, AR, CDKN2A, ATP2A2
4	mortality/aging	MP:0010768	7.4	RYR1, DTNA, HSPA5, MAPT, AR, CLCN1
5	respiratory system phenotype	MP:0005388	7.1	HCRT, TNF, RYR1, ADIPOQ, HSPA5, INSR
6	growth/size phenotype	MP:0005378	7.1	AR, MAPT, HSPA5, DTNA, CELF1, RYR1
7	cardiovascular system phenotype	MP:0005385	6.4	SOD1, ATP2A2, AR, INSR, HSPA5, DTNA
8	endocrine/exocrine gland phenotype	MP:0005379	6.4	SIX5, SOD1, INSR, AR, CD40LG, CELF1
9	skeleton phenotype	MP:0005390	6.3	ATXN1, CDKN2A, CLCN1, CD40LG, AR, RYR1
10	reproductive system phenotype	MP:0005389	5.9	CLCN1, CELF1, KCNN3, ADIPOQ, SIX5, SOD1
11	behavior/neurological phenotype	MP:0005386	5.2	HCRTR1, HCRTR2, SOD1, INSR, RYR1, ADIPOQ
12	homeostasis/metabolism phenotype	MP:0005376	5.1	RYR1, SOD1, HCRT, DMPK, TNF, HSPA5
13	muscle phenotype	MP:0005369	4.5	ATXN1, CLCN1, ATP2A3, ATP2A1, ATP2A2, CDKN2A

Articles related to myotonic dystrophy type 1:

(show top 50)    (show all 51)

id	Title	Authors	Year	Affiliating Genes
1	Decreased concentration of adiponectin together with a selective reduction of its high molecular weight oligomers is involved in met abolic complications of myotonic dystrophy type 1. (21964963)	Daniele A.... Di Costanzo A.	2011	ADIPOQ
2	Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1. (21794030)	Koebis M.... Ishiura S.	2011	MYOM1
3	Haplotype analysis of the myotonic dystrophy type 1 ( DM1) locus in the Korean population. (20421627)	Kwon M.J.... Ki C.S.	2010	DMPK
4	Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. (20487562)	Gambardella S.... Botta A.	2010	MIR206
5	Heart-specific overexpression of CUGBP1 reproduces fu nctional and molecular abnormalities of myotonic dystrophy type 1. (20051426)	Koshelev M.... Cooper T.A.	2010	MBNL1, CELF1
6	Myotonic dystrophy type 1 and PGD: ovarian stimulatio n response and correlation analysis between ovarian reserve and genotype. (20231114)	Dechanet C.... Anahory T.	2010	DMPK
7	CUGBP1 overexpression in mouse skeletal muscle reprod uces features of myotonic dystrophy type 1. (20603324)	Ward A.J.... Cooper T.A.	2010	CELF1
8	Analysis of MTMR1 expression and correlation with mus cle pathological features in juvenile/adult onset myotonic dystrophy type 1 (DM 1) and in myotonic dystrophy type 2 (DM2). (20685272)	Santoro M.... Silvestri G.	2010	DMPK, MTMR1
9	Model for alternative splicing of insulin receptor in myotonic dystrophy type 1. (19902080)	Tonevitsky E.A.... Trushkin E.V.	2009	INSR
10	Analysis of repetitive regions in myotonic dystrophy type 1 and 2. (19360700)	Carson N.L.	2009	CNBP
11	Large CTG repeats trigger p16-dependent premature sen escence in myotonic dystrophy type 1 muscle precursor cells. (19246640)	Bigot A.... Furling D.	2009	CDKN2A
12	Autism spectrum conditions in myotonic dystrophy type 1: a study on 57 individuals with congenital and childhood forms. (18228241)	Ekstrom A.B.... Wentz E.	2008	DMPK
13	Correlation among subcortical white matter lesions, intelligence and CTG repeat expansion in classic myotonic dystrophy type 1. (18184345)	Kuo H.C.... Huang C.C.	2008	DMPK
14	Molecular and clinical characteristics of myotonic dystrophy type 1 in koreans. (19127114)	Kim S.Y.... Park S.S.	2008	DMPK
15	The hypocretin neurotransmission system in myotonic dystrophy type 1. (18195268)	Ciafaloni E.... Thornton C.A.	2008	HCRTR2, HCRTR1, HCRT
16	CTG repeat instability in a human embryonic stem cell line carrying the myotonic dystrophy type 1 mutation. (18577525)	De Temmerman N.... Sermon K.D.	2008	DMPK
17	A putative role of ribonuclear inclusions and MBNL1 in the impairment of gallbladder smooth muscle contractility with cholelithiasis in myotonic dystrophy type 1. (18653337)	Cardani R.... Meola G.	2008	MBNL1
18	Analysis of Single Nucleotide Polymorphisms (SNPs) of the small-conductance calcium activated potassium channel (SK3) gene as geneti c modifier of the cardiac phenotype in myotonic dystrophy type 1 patients. (19472917)	Rinaldi F.... Novelli G.	2008	KCNN3, KCNN1
19	Myotonic dystrophy type 1 coexisting with myasthenia gravis and thymoma. (18563724)	Feyma T.... Weiss M.D.	2008	DMPK
20	Aberrantly spliced alpha-dystrobrevin alters alpha-syntrophin binding in myotonic dystrophy type 1. (18299519)	Nakamori M.... Sakoda S.	2008	DTNA
21	The CTG repeat expansion size correlates with the splicing defects observed in muscles from myotonic dystrophy type 1 patients. (18611984)	Botta A.... Novelli G.	2008	DMPK, CLCN1
22	Inheritance of a novel RYR1 mutation in a family with myotonic dystrophy type 1. (17204054)	Gambelli S.... Dotti M.T.	2007	RYR1
23	Preimplantation genetic diagnosis for myotonic dystrophy type 1: detection of crossover between the gene and the linked marker APOC2. (17192963)	Kakourou G.... Sengupta S.	2007	DMPK
24	Cognitive profile in childhood myotonic dystrophy type 1: is there a global impairment? (17433680)	Angeard N.... Heron D.	2007	DMPK
25	Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle. (17661063)	Ikezoe K.... Kira J.	2007	HSPA5, RYR1, ATP2A3
26	Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. (17728322)	Hino S.... Imaizumi K.	2007	ATP2A1, DMPK
27	MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. (16723374)	de Haro M.... Botas J.	2006	DMPK, MBNL1, CELF1
28	Clinical characteristics of myotonic dystrophy type 1 patients with small CTG expansions. (16636244)	Arsenault M.E.... Mathieu J.	2006	DMPK
29	Myotonic dystrophies type 1 and 2: a summary on curre nt aspects. (17027856)	Schara U.... Schoser B.G.	2006	CD40LG
30	Oxidative stress in myotonic dystrophy type 1. (16036357)	Toscano A.... Vita G.	2005	SOD1
31	Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1. (15972723)	Kimura T.... Sakoda S.	2005	ATP2A1, ATP2A2, RYR1
32	Decreased expression of DMPK: correlation with CTG repeat expansion and fibre type composition in myotonic dystrophy type 1. (16193250)	Salvatori S.... Angelini C.	2005	DMPK
33	Myotonic dystrophy type 1 in cataract patients: molecular diagnosis for screening and genetic counseling (15824798)	Rojas M.V.... Simoes A.L.	2005	DMPK
34	The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions. (15489504)	Wojciechowska M.... Wells R.D.	2005	DMPK
35	Psychosocial impact of predictive testing for myotonic dystrophy type 1. (15039975)	Prevost C.... Mathieu J.	2004	DMPK, DM1
36	No association of the SCA1 (CAG)31 allele with Huntington's disease, myotonic dystrophy type 1 and spinocerebellar ataxia type 3. (15167689)	Hellenbroich Y.... Zuhlke C.	2004	ATXN1
37	Association of spinal and bulbar muscular atrophy with myotonic dystrophy type 1. (15116379)	Jinnai K.... Takahashi K.	2004	DMPK
38	Improved method for molecular diagnosis of myotonic dystrophy type 1 (DM1). (14730559)	Erginel-Unaltuna N.... Akbas F.	2004	DMPK
39	Leukocyte CTG repeat length correlates with severity of myotonia in myotonic dystrophy type 1. (15079005)	Logigian E.L.... Moxley R.T.	2004	DMPK, DM1
40	Heart rate variability declines with increasing age and CTG repeat length in patients with myotonic dystrophy type 1. (14510658)	Hardin B.A.... Groh W.J.	2003	DMPK, DM1
41	Transgenic mouse models for myotonic dystrophy type 1 (DM1). (14526185)	Wansink D.G.... Wieringa B.	2003	DMWD
42	Instability of a premutation allele in homozygous pat ients with myotonic dystrophy type 1. (12325072)	Abbruzzese C.... Giacanelli M.	2002	DMPK
43	Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1. (11978764)	Sato S.... Kawakami K.	2002	DMPK, SIX5
44	Tumor necrosis factor-alpha and myocardial function in patients with myotonic dystrophy type 1. (12163195)	Mammarella A.... Basili S.	2002	TNF
45	Paternal transmission of the congenital form of myotonic dystrophy type 1: a new case and review of the literature. (11807903)	Zeesman S.... Whelan D.T.	2002	DMPK
46	Increased (CTG/CAG)(n) lengths in myotonic dystrophy type 1 and Machado-Joseph disease genes in idiopathic azoospermia patients. (12042281)	Pan H.... Hsiao K.M.	2002	AR
47	Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2. (11590133)	Mankodi A.... Thornton C.A.	2001	MBNL1
48	Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1. (11590131)	Sergeant N.... Delacourte A.	2001	MAPT
49	Stapedial reflex in myotonic dystrophy type 1 and CTG repeat expansion. (12013582)	Osanai R.... Hirose K.	2001	DMPK
50	Myotonic Dystrophy Type 1 (20301344)	Bird T.D.	1993	DMPK

Genes related to myotonic dystrophy type 1 according to GeneCards:

(show all 31)

id	Symbol	Description	Score	GeneCards Section Context
1	CELF1	CUGBP, Elav-like family member 1	11.1	Publications, Summaries
2	DM1	dystrophia myotonica 1 (includes dystrophia myotonia protein kinase)	11.0	Publications
3	MIR206	microRNA 206	11.0	Publications
4	DMPK	dystrophia myotonica-protein kinase	11.0	Publications
5	DMWD	dystrophia myotonica, WD repeat containing	11.0	Publications
6	SIX5	SIX homeobox 5	11.0	Publications
7	ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	11.0	Publications
8	MTMR1	myotubularin related protein 1	11.0	Publications
9	KCNN1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	11.0	Publications
10	MBNL1	muscleblind-like splicing regulator 1	11.0	Publications
11	HCRTR1	hypocretin (orexin) receptor 1	11.0	Publications
12	CNBP	CCHC-type zinc finger, nucleic acid binding protein	11.0	Publications
13	CLCN1	chloride channel, voltage-sensitive 1	11.0	Publications
14	ATP2A3	ATPase, Ca++ transporting, ubiquitous	11.0	Publications
15	HCRTR2	hypocretin (orexin) receptor 2	11.0	Publications
16	KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	11.0	Publications
17	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	11.0	Publications
18	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
19	MYOM1	myomesin 1, 185kDa	11.0	Publications
20	RYR1	ryanodine receptor 1 (skeletal)	11.0	Publications
21	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	11.0	Publications
22	DTNA	dystrobrevin, alpha	11.0	Publications
23	INSR	insulin receptor	11.0	Publications
24	ATXN1	ataxin 1	11.0	Publications
25	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
26	AR	androgen receptor	11.0	Publications
27	CD40LG	CD40 ligand	11.0	Publications
28	MAPT	microtubule-associated protein tau	11.0	Publications
29	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
30	SOD1	superoxide dismutase 1, soluble	11.0	Publications
31	TNF	tumor necrosis factor	11.0	Publications

Pathways related to myotonic dystrophy type 1 according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Platelet calcium homeostasis38	10.0	ATP2A2, ATP2A1, ATP2A3
2	Calcium Mediated T-Cell Apoptosis36	9.6	ATP2A3, ATP2A1, ATP2A2
3	Beta-Adrenergic Signaling36	9.5	RYR1, ATP2A2, ATP2A1, ATP2A3
4	Type II diabetes mellitus20	9.3	ADIPOQ, TNF, INSR
5	Alzheimers disease20	8.8	TNF, MAPT, ATP2A2, ATP2A1, ATP2A3

Compounds related to myotonic dystrophy type 1 according to GeneDecks:

(show top 50)    (show all 58)

id	Compound	Score	Top Affiliating Genes
1	sb 40812442	10.4	HCRTR1, HCRT
2	sb 33486742	10.4	HCRT, HCRTR1
3	ucl 168442	10.4	KCNN1, KCNN3
4	scyllatoxin32	10.4	KCNN3, KCNN1
5	[ala11,d-leu15]-orexin b 42	10.4	HCRT, HCRTR2
6	bhq42	10.3	ATP2A3, ATP2A1, ATP2A2
7	pom 142	10.3	ATP2A2, ATP2A1, ATP2A3
8	ruthenium32	10.1	HSPA5, ATP2A3, RYR1
9	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate9 9	11.1	ATP2A1, INSR
10	glucose32	10.1	RYR1, HCRTR1, DMPK, ATP2A3
11	cyclopiazonic acid32 42	11.1	ATP2A1, RYR1, ATP2A2, ATP2A3
12	ryanodine32	10.0	ATP2A3, ATP2A2, DMPK, RYR1
13	ascorbic acid32 18	10.5	HSPA5, CD40LG, AR
14	nsc3432	9.5	AR, SOD1
15	potassium32 9 18 9	12.5	KCNN1, KCNN3, ATP2A3, HCRT, HCRTR1, RYR1
16	nitric oxide32 9 18 9	12.5	HCRT, CDKN2A, ATP2A3, ATP2A2
17	n acetylcysteine32	9.4	MAPT, CDKN2A, AR
18	gliclazide32 34 9 9	12.3	SOD1, ADIPOQ, INSR
19	ionomycin32	9.2	TNF, HSPA5, CD40LG, ATP2A3, KCNN1
20	fenofibrate32 9 9	11.2	CD40LG, ADIPOQ, TNF, INSR
21	calcium32 9 18 9	12.1	HCRTR2, ATP2A1, ATP2A3, KCNN3, KCNN1, DMPK
22	norepinephrine32 9 18 9	12.1	ADIPOQ, RYR1, HCRTR2, ATP2A2, HCRT, CD40LG
23	gsno32	9.1	SOD1, INSR, RYR1
24	thapsigargin32 42	10.0	HCRTR1, RYR1, HSPA5, HCRT, ATP2A2, ATP2A1
25	8-isoprostane32	8.9	TNF, SOD1, ADIPOQ
26	mg 13232 42	9.9	CDKN2A, AR, MAPT
27	troglitazone32 42 9 9	11.9	AR, TNF, ADIPOQ, INSR
28	cocaine32 9 9	10.9	ADIPOQ, HCRT, AR, CD40LG
29	lactacystin32	8.8	AR, MAPT, INSR, TNF, HSPA5
30	valine32	8.7	HSPA5, AR, INSR, CDKN2A, MAPT
31	creatinine32	8.6	ADIPOQ, RYR1, CD40LG, CDKN2A, MAPT
32	atp32	8.6	ATP2A3, CNBP, ATP2A1, KCNN1, CDKN2A, HSPA5
33	glutamine32	8.4	INSR, RYR1, MAPT, ATXN1, KCNN3, KCNN1
34	doxorubicin32 34 9 9	11.3	RYR1, MAPT, HSPA5, CDKN2A, CD40LG, AR
35	testosterone32 9 18 9	11.2	MAPT, ATXN1, CDKN2A, CD40LG, AR, INSR
36	acetylcholine32 9 18 9	11.0	INSR, DMPK, HCRTR1, HCRTR2, CD40LG, RYR1
37	egcg32	7.9	CDKN2A, HSPA5, SOD1, TNF
38	dopamine32 9 18 9	10.9	HSPA5, CDKN2A, CD40LG, INSR, HCRT, HCRTR1
39	aspartate32	7.9	RYR1, ADIPOQ, INSR, MAPT, CDKN2A, AR
40	genistein32 9 18 9	10.7	INSR, MAPT, HSPA5, TNF, CD40LG, CDKN2A
41	lactate32	7.7	ADIPOQ, TNF, HSPA5, SOD1, CD40LG, MAPT
42	dexamethasone32 42 34 9 9	11.7	ADIPOQ, HCRT, TNF, INSR, AR, CD40LG
43	estrogen32	7.5	AR, MAPT, HSPA5, HCRT, ADIPOQ, INSR
44	actinomycin d32	7.4	AR, CDKN2A, ADIPOQ, TNF, HSPA5, MAPT
45	glutamate32	7.4	AR, RYR1, CD40LG, MAPT, ADIPOQ, INSR
46	lipid32	7.1	SOD1, HCRT, HSPA5, INSR, TNF, RYR1
47	alanine32	6.9	HCRT, ADIPOQ, RYR1, SOD1, HCRTR2, CDKN2A
48	arginine32	6.6	CNBP, HSPA5, ADIPOQ, AR, RYR1, CDKN2A
49	serine32	6.5	INSR, HSPA5, TNF, ATP2A2, RYR1, ADIPOQ
50	h2o232	6.4	CDKN2A, AR, ATP2A3, MAPT, HSPA5, KCNN3

Cellular components related to myotonic dystrophy type 1 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet dense tubular network membrane	GO:031095	9.8	ATP2A1, ATP2A2, ATP2A3
2	sarcoplasmic reticulum	GO:016529	9.6	RYR1, ATP2A2, ATP2A1, ATP2A3
3	sarcoplasmic reticulum membrane	GO:033017	9.5	ATP2A3, ATP2A1, RYR1, DMPK, ATP2A2
4	integral to plasma membrane	GO:005887	8.1	RYR1, HCRTR2, HCRTR1, TNF, INSR, CD40LG
5	protein complex	GO:043234	7.8	ATP2A2, CDKN2A, AR, DTNA, SOD1

Biological processes related to myotonic dystrophy type 1 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP biosynthetic process	GO:006754	9.6	ATP2A3, ATP2A2, ATP2A1
2	regulation of immunoglobulin secretion	GO:051023	9.5	CD40LG, TNF
3	synaptic transmission	GO:007268	9.1	DTNA, HCRTR2, HCRTR1, KCNN1, KCNN3, HCRT

Molecular functions related to myotonic dystrophy type 1 according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	small conductance calcium-activated potassium channel activity	GO:016286	10.1	KCNN1, KCNN3
2	calcium-transporting ATPase activity	GO:005388	9.8	ATP2A3, ATP2A1, ATP2A2
3	orexin receptor activity	GO:016499	9.8	HCRTR1, HCRTR2