Aliases & Classifications for Myxedema

MalaCards integrated aliases for Myxedema:

Name: Myxedema 53 12 72 51 41 14 69

Characteristics:

OMIM:

53
Inheritance:
autosomal recessive, sex-influenced
environmental factors not excluded


Classifications:



Summaries for Myxedema

MalaCards based summary : Myxedema is related to congenital hypothyroidism and graves' disease, and has symptoms including constipation, fatigue and muscle weakness. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. Affiliated tissues include thyroid, heart and skin.

Wikipedia : 72 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

Description from OMIM: 255900

Related Diseases for Myxedema

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 31.3 TG TPO TSHR
2 graves' disease 31.2 CTLA4 TG TPO TSHR
3 exophthalmos 30.2 TG TSHR
4 hypothyroidism 30.1 TG TPO TSHR
5 thyroiditis 29.9 CTLA4 TG TPO TSHR
6 graves disease 1 29.7 TG TPO TSHR
7 goiter 29.5 TG TPO TSHR
8 pernicious anemia 29.4 TG TPO
9 hyperthyroidism 29.3 CTLA4 TG TPO TSHR
10 hypothyroidism, congenital, nongoitrous, 4 29.3 TG TPO
11 nontoxic goiter 29.0 TG TPO TSHR
12 hashimoto thyroiditis 28.9 CTLA4 TG TPO TSHR
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 28.8 CTLA4 TG TPO TSHR
14 thyroid cancer 28.6 TG TPO TSHR
15 autoimmune polyendocrine syndrome, type ii 11.1
16 megaloblastic anemia 1 10.9
17 hyperthyroidism, nonautoimmune 10.9
18 nodular lichen myxedematosus 10.9
19 orbital plasma cell granuloma 10.2 CTLA4 TSHR
20 benign struma ovarii 10.2 TG TSHR
21 athyreosis 10.2 TG TSHR
22 chronic orbital inflammation 10.2 CTLA4 TSHR
23 struma ovarii 10.2 TG TSHR
24 hypothyroidism, congenital, nongoitrous, 2 10.2 TG TSHR
25 syndrome of inappropriate antidiuretic hormone 10.2 AVP NPPA
26 papillary thyroid microcarcinoma 10.1 TG TSHR
27 hyperthyroxinemia 10.1 TPO TSHR
28 familial thyroid dyshormonogenesis 10.0 TG TPO
29 subacute lymphocytic thyroiditis 10.0 TG TPO
30 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.0 TG TPO
31 heart disease 10.0
32 plummer's disease 10.0 TG TPO
33 premature menopause 10.0 TG TPO
34 cardiac tamponade 10.0
35 immune system disease 9.9 CTLA4 TG TSHR
36 respiratory failure 9.9
37 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 9.9 TG TPO
38 hypoadrenocorticism, familial 9.9 CTLA4 TPO
39 ataxia and polyneuropathy, adult-onset 9.8
40 megacolon 9.8
41 hemopericardium 9.8
42 pericardial effusion 9.8
43 myopathy 9.8
44 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8 CTLA4 TPO
45 neonatal hypothyroidism 9.8 TG TPO TSHR
46 endemic goiter 9.8 TG TPO TSHR
47 subacute thyroiditis 9.8 TG TPO TSHR
48 toxic diffuse goiter 9.8 TG TPO TSHR
49 nodular goiter 9.8 TG TPO TSHR
50 thyroid gland disease 9.8 TG TPO TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to Myxedema

Symptoms & Phenotypes for Myxedema

Symptoms via clinical synopsis from OMIM:

53
GI:
constipation

Endocrine:
hypothyroidism

Neuro:
paresthesias
decreased memory

Lab:
high tsh
low free t4

Misc:
fatigue
lethargy
weakness
cold intolerance
thyrotoxicosis in relatives
more
Muscle:
muscle cramps

Skin:
decreased sweating
coarse, dry skin
puffy, non-pitting swelling of face, hands and limbs

Voice:
husky


Clinical features from OMIM:

255900

Human phenotypes related to Myxedema:

31 (show all 12)
# Description HPO Frequency HPO Source Accession
1 constipation 31 HP:0002019
2 fatigue 31 HP:0012378
3 muscle weakness 31 HP:0001324
4 lethargy 31 HP:0001254
5 hypothyroidism 31 HP:0000821
6 hypohidrosis 31 HP:0000966
7 memory impairment 31 HP:0002354
8 paresthesia 31 HP:0003401
9 muscle cramps 31 HP:0003394
10 hoarse voice 31 HP:0001609
11 easy fatigability 31 HP:0003388
12 increased thyroid-stimulating hormone level 31 HP:0002925

Drugs & Therapeutics for Myxedema

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lipid Metabolic Status in Thyroid Carcinoma Completed NCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

Anatomical Context for Myxedema

MalaCards organs/tissues related to Myxedema:

38
Thyroid, Heart, Skin, Pituitary, Colon, Bone, Testes

Publications for Myxedema

Articles related to Myxedema:

(show top 50) (show all 564)
# Title Authors Year
1
Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. ( 29232051 )
2018
2
Undiagnosed myxedema coma: Rare but life-threatening. ( 29416497 )
2018
3
Response to topical halcinonide following fractional carbon dioxide laser pretreatment in a pretibial myxedema patient. ( 29363626 )
2018
4
Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies. ( 29093409 )
2018
5
Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report. ( 29448964 )
2018
6
Elephantiasic Pretibial Myxedema with Involvement of the Buttocks and Face. ( 28748868 )
2017
7
Annularly arranged nodular pretibial myxedema after 7-year treatment of Graves' disease. ( 28150342 )
2017
8
Routine Treatment-Resistant<i>Clostridium difficile</i>Infection during Recovery from Myxedema. ( 29430228 )
2017
9
Sudden cardiac arrest as a rare presentation of myxedema coma: case report. ( 29147476 )
2017
10
Rapid Response to Loading Dose Levothyroxine in Myxedema Psychosis. ( 28102974 )
2017
11
Pretibial Myxedema Masquerading as a Venous Leg Ulcer. ( 28355140 )
2017
12
Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma. ( 29026577 )
2017
13
Treatment of pretibial myxedema with intralesional immunomodulating therapy. ( 28932121 )
2017
14
Unusual Case of a Massive Macroglossia Secondary to Myxedema: A Case Report and Literature Review. ( 28742994 )
2017
15
Diagnosis of myxedema coma complicated by renal failure: a case report. ( 28396755 )
2017
16
Intracerebral Bleeding and Massive Pericardial Effusion as Presenting Symptoms of Myxedema Crisis. ( 28255471 )
2017
17
Myxedema Crisis Presenting with Seizures: A Rare Life-Threatening Presentation-A Case Report and Review of the Literature. ( 28540093 )
2017
18
Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion. ( 28670061 )
2017
19
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
20
Nivolumab induced myxedema crisis. ( 28239466 )
2017
21
Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan. ( 28142035 )
2017
22
Myxedema coma: A case report of pediatric emergency care. ( 28538388 )
2017
23
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. ( 27504447 )
2016
24
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. ( 27631398 )
2016
25
Impending myxedema coma as the initial presentation of lung cancer. ( 27823924 )
2016
26
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. ( 28083456 )
2016
27
Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. ( 27648339 )
2016
28
Periorbital Myxedema. ( 27802562 )
2016
29
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. ( 26924647 )
2016
30
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). ( 27583414 )
2016
31
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. ( 26873132 )
2016
32
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. ( 27872766 )
2016
33
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India. ( 26019115 )
2015
34
Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. ( 26000037 )
2015
35
Computed tomography and magnetic resonance imaging findings of ureteral myxedema in Graves' disease. ( 25766333 )
2015
36
A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS). ( 26155541 )
2015
37
A Randomized Controlled Trial of Intralesional Glucocorticoid for Treating Pretibial Myxedema. ( 26491499 )
2015
38
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
39
Myxedema madness: a case for short-term antipsychotics? ( 25870443 )
2015
40
Images in clinical medicine. Myxedema. ( 25693016 )
2015
41
Dermoscopy of pretibial myxedema. ( 26568347 )
2015
42
Development of an objective tool for the diagnosis of myxedema coma. ( 25647622 )
2015
43
Pre-tibial myxedema: treatment with intralesional corticosteroid. ( 26312698 )
2015
44
Myxedema coma with cardiac tamponade and severe cardiomyopathy. ( 26424958 )
2015
45
Eczema craquelAc, an uncommon clinical manifestation of myxedema. ( 25918092 )
2015
46
Nodular Foot Myxedema Masquerading as Lymphedema. ( 26301146 )
2015
47
Myxedema madness complicating postoperative follow-up of thyroid cancer. ( 26331326 )
2015
48
Pretibial myxedema. ( 26231090 )
2015
49
A diagnostic scoring system for myxedema coma. ( 24518183 )
2014
50
Amiodarone-induced myxedema coma - a case and review of the literature. ( 25624868 )
2014

Variations for Myxedema

Expression for Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for Myxedema

GO Terms for Myxedema

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.33 AVP NPPA TG
2 regulation of blood vessel size GO:0050880 8.96 AVP NPPA
3 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 AVP NPPA
2 hormone activity GO:0005179 8.8 AVP NPPA TG

Sources for Myxedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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