MCID: MYX004
MIFTS: 35

Myxedema malady

Categories: Endocrine diseases

Aliases & Classifications for Myxedema

Aliases & Descriptions for Myxedema:

Name: Myxedema 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11634
ICD10 33 E03.9
MeSH 42 D009230
NCIt 47 C34834
UMLS 69 C0027145

Summaries for Myxedema

MalaCards based summary : Myxedema is related to graves' disease and congenital hypothyroidism. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Allograft rejection and Insulin secretion. Affiliated tissues include thyroid, heart and pituitary.

Wikipedia : 71 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

Related Diseases for Myxedema

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
id Related Disease Score Top Affiliating Genes
1 graves' disease 11.2
2 congenital hypothyroidism 10.9
3 nodular lichen myxedematosus 10.8
4 megaloblastic anemia-1, finnish type 10.8
5 hyperthyroidism, nonautoimmune 10.8
6 autoimmune polyendocrine syndrome, type ii 10.8
7 thyroiditis 10.4
8 hypothyroidism 10.2
9 primary lacrimal atrophy 10.2 CTLA4 TSHR
10 acute hemorrhagic encephalitis 10.1 TG TSHR
11 gastrinoma 10.1 TG TSHR
12 mesocardia 10.1 TG TSHR
13 parachordoma 10.1 TG TSHR
14 syringomelia hyperkeratosis 10.1 AVP NPPA
15 neuronopathy, distal hereditary motor, type viia 10.1 TG TSHR
16 acute laryngitis 10.0 TG TSHR
17 exophthalmos 10.0
18 fibrous meningioma 9.9 TG TPO
19 hyperthyroidism 9.9
20 premature closure of the arterial duct 9.9 TG TPO
21 heart disease 9.9
22 tick paralysis 9.9 TG TPO
23 frontal sinusitis 9.9 TG TPO
24 caudal regression syndrome 9.9 TG TPO
25 nail disorder, nonsyndromic congenital, 7 9.9 CTLA4 TPO
26 color blindness 9.9 TG TPO
27 cardiac tamponade 9.8
28 respiratory failure 9.8
29 dysautonomia, familial 9.8 TG TPO
30 hypermobility syndrome 9.8 CTLA4 TPO
31 neuhauser daly magnelli syndrome 9.8 TG TPO TSHR
32 background diabetic retinopathy 9.8 TG TPO TSHR
33 krabbe disease 9.8 TG TPO TSHR
34 endemic goiter 9.8 TG TPO TSHR
35 mixed eosinophil-basophil adenoma 9.8 TG TPO TSHR
36 hypothyroidism, congenital, nongoitrous, 1 9.8 TG TPO TSHR
37 broad ligament malignant neoplasm 9.8 TG TPO TSHR
38 nodular prostate 9.8 TG TPO TSHR
39 exanthema subitum 9.8 TG TPO TSHR
40 peritoneal serous papillary adenocarcinoma 9.8 TG TPO TSHR
41 commensal bacterial infectious disease 9.8 TG TPO TSHR
42 aflatoxins-related hepatocellular carcinoma 9.8 TG TPO TSHR
43 otosclerosis 9.8 TG TPO TSHR
44 choreoathetosis, hypothyroidism, and neonatal respiratory distress 9.8 TG TPO TSHR
45 goiter 9.8
46 tenosynovitis of foot and ankle 9.8 TG TPO TSHR
47 non-distal monosomy 10q 9.8 TG TPO TSHR
48 muscular dystrophy-dystroglycanopathy , type a, 10 9.8 TG TPO TSHR
49 dihydrolipoamide dehydrogenase deficiency 9.8 TG TPO
50 cholesterol embolism 9.8 TG TPO TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to Myxedema

Symptoms & Phenotypes for Myxedema

Drugs & Therapeutics for Myxedema

Interventional clinical trials:


id Name Status NCT ID Phase
1 Lipid Metabolic Status in Thyroid Carcinoma Completed NCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

Anatomical Context for Myxedema

MalaCards organs/tissues related to Myxedema:

39
Thyroid, Heart, Pituitary, Skin, Colon, Testes, Bone

Publications for Myxedema

Articles related to Myxedema:

(show top 50) (show all 540)
id Title Authors Year
1
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
2
Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. ( 27648339 )
2016
3
Impending myxedema coma as the initial presentation of lung cancer. ( 27823924 )
2016
4
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. ( 28083456 )
2016
5
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. ( 26873132 )
2016
6
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. ( 27872766 )
2016
7
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. ( 27504447 )
2016
8
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). ( 27583414 )
2016
9
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. ( 27631398 )
2016
10
Periorbital Myxedema. ( 27802562 )
2016
11
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. ( 26924647 )
2016
12
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
13
Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. ( 26000037 )
2015
14
Computed tomography and magnetic resonance imaging findings of ureteral myxedema in Graves' disease. ( 25766333 )
2015
15
A Randomized Controlled Trial of Intralesional Glucocorticoid for Treating Pretibial Myxedema. ( 26491499 )
2015
16
A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS). ( 26155541 )
2015
17
Dermoscopy of pretibial myxedema. ( 26568347 )
2015
18
Myxedema madness complicating postoperative follow-up of thyroid cancer. ( 26331326 )
2015
19
Eczema craquelAc, an uncommon clinical manifestation of myxedema. ( 25918092 )
2015
20
Nodular Foot Myxedema Masquerading as Lymphedema. ( 26301146 )
2015
21
Pretibial myxedema. ( 26231090 )
2015
22
Myxedema coma with cardiac tamponade and severe cardiomyopathy. ( 26424958 )
2015
23
Development of an objective tool for the diagnosis of myxedema coma. ( 25647622 )
2015
24
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India. ( 26019115 )
2015
25
Myxedema madness: a case for short-term antipsychotics? ( 25870443 )
2015
26
Pre-tibial myxedema: treatment with intralesional corticosteroid. ( 26312698 )
2015
27
Images in clinical medicine. Myxedema. ( 25693016 )
2015
28
Pretibial Myxedema Associated with Euthyroid Hashimoto's Thyroiditis: A Case Report. ( 25121051 )
2014
29
Pretibial myxedema. ( 25184646 )
2014
30
Myxedema. ( 24931819 )
2014
31
A case report on myxedema madness: curable psychosis. ( 24701017 )
2014
32
Myxedema coma induced by short-term amiodarone therapy. ( 24521765 )
2014
33
Heart failure presenting as myxedema coma: case report and review article. ( 24592692 )
2014
34
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. ( 26060688 )
2014
35
A diagnostic scoring system for myxedema coma. ( 24518183 )
2014
36
Dramatic effect of low-dose oral steroid on elephantiasic pretibial myxedema. ( 25200964 )
2014
37
Amiodarone-induced myxedema coma - a case and review of the literature. ( 25624868 )
2014
38
Pretibial Myxedema: Case Presentation and Review of Treatment Options. ( 24807996 )
2014
39
Elephantiasic pretibial myxedema in a patient with graves disease that resolved after 131I treatment. ( 24830877 )
2014
40
Treatment of pretibial myxedema with dexamethazone injected subcutaneously by mesotherapy needles. ( 23397966 )
2013
41
Myxedema ascites with high CA-125: Case and a review of literature. ( 23646234 )
2013
42
Preradial myxedema in a euthyroid male: A distinct rarity. ( 24021369 )
2013
43
Heart failure presenting as myxedema coma: case report and review article. ( 23691872 )
2013
44
Amenorrhea with myxedema: A hidden clue. ( 23776924 )
2013
45
Lithium toxicity and myxedema crisis in an elderly patient. ( 24910829 )
2013
46
Myxedema coma: a sleeping giant in clinical practice. ( 24262739 )
2013
47
Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease. ( 23514670 )
2013
48
Severe hypothyroidism presenting as myxedema coma in the postoperative period in a patient taking sunitinib: case report and review of literature. ( 23246982 )
2013
49
Localized myxedema of thyroid disease. ( 23680216 )
2013
50
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. ( 24557975 )
2013

Variations for Myxedema

Expression for Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for Myxedema

GO Terms for Myxedema

Cellular components related to Myxedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 ATP6V1A CTLA4 LGR6 TPO TSHR

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cAMP biosynthetic process GO:0030819 9.16 AVP TSHR
2 regulation of blood vessel size GO:0050880 8.96 AVP NPPA
3 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 AVP NPPA
2 hormone activity GO:0005179 8.8 AVP NPPA TG

Sources for Myxedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....