Aliases & Classifications for Myxedema

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Aliases & Descriptions for Myxedema:

Name: Myxedema 11 49 38 13 67
 
Myxoedema 11

Classifications:



External Ids:

Disease Ontology11 DOID:11634
ICD1029 E03.9
MeSH38 D009230
NCIt44 C34834

Summaries for Myxedema

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Wikipedia:70 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

MalaCards based summary: Myxedema, also known as myxoedema, is related to pericarditis and hashimoto thyroiditis, and has symptoms including umbilical discharge, osler's node and abnormal granulation tissue. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs thyroid (usp) and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skin.

Related Diseases for Myxedema

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Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis28.7TG, TPO, TSHR
2hashimoto thyroiditis28.4CTLA4, TG, TPO, TSHR
3graves' disease11.2
4congenital hypothyroidism10.9
5megaloblastic anemia-1, finnish type10.8
6hyperthyroidism, nonautoimmune10.8
7autoimmune polyendocrine syndrome, type ii10.8
8nodular lichen myxedematosus10.8
9thyroiditis10.4
10peptic esophagitis10.3CTLA4, TSHR
11pseudomarfanism10.3AVP, NPPA
12demyelinating polyneuropathy10.3TG, TSHR
13malignant syringoma10.3TG, TSHR
14acquired central diabetes insipidus10.3TG, TSHR
15benign mesothelioma10.3TG, TSHR
16hypothyroidism10.2
17acute liver failure10.2AVP, NPPA
18substernal goiter10.2TG, TSHR
19glaucomatocyclitic crisis10.1TG, TSHR
20tinea corporis10.1SERPINA7, TG
21cerebral lipidosis10.1SERPINA7, TG
22iatrogenic or traumatic pituitary deficiency10.1TG, TPO
23ovarian endometrioid cystadenoma10.0TG, TPO
24rhabdomyosarcoma, embryonal, 210.0TG, TPO
25lung occult adenocarcinoma10.0SERPINA7, TG
26peripheral scars of retina10.0TG, TPO
27craniopharyngioma10.0AVP, SERPINA7
28exophthalmos10.0
29chronic frontal sinusitis10.0TG, TPO
30hyperthyroidism9.9
31hypothryoidism, congenital, nongoitrous 49.9TG, TPO
32heart disease9.9
33hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia9.9SERPINA7, TG, TSHR
34nail disorder, nonsyndromic congenital, 79.9CTLA4, TPO
35respiratory failure9.9
36cardiac tamponade9.9
37dysautonomia, familial9.8TG, TPO
38goiter9.8
39crohn's disease of the esophagus9.8TG, TPO, TSHR
40meningovascular neurosyphilis9.8TG, TPO, TSHR
41primary bacterial infectious disease9.8TG, TPO, TSHR
42kidney benign neoplasm9.8TG, TPO, TSHR
43deafness, autosomal recessive 4, with enlarged vestibular aqueduct9.8TG, TPO
44atrial standstill9.8TG, TPO, TSHR
45frontotemporal dementia and/or amyotrophic lateral sclerosis 49.8TG, TPO, TSHR
46megacolon9.8
47myopathy9.8
48ataxia9.8
49chorea, hereditary benign9.7TG, TPO, TSHR
50richter's syndrome9.7TG, TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms for Myxedema

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UMLS symptoms related to Myxedema:


umbilical discharge, osler's node, abnormal granulation tissue, hard edema, skin symptom

Drugs & Therapeutics for Myxedema

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Lipid Metabolic Status in Thyroid CarcinomaCompletedNCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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MalaCards organs/tissues related to Myxedema:

35
Thyroid, Heart, Skin, Pituitary, Colon, Testes, Bone

Animal Models for Myxedema or affiliated genes

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Publications for Myxedema

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Articles related to Myxedema:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. (26924647)
2016
2
Impending myxedema coma as the initial presentation of lung cancer. (27823924)
2016
3
Periorbital Myxedema. (27802562)
2016
4
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). (27583414)
2016
5
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. (27872766)
2016
6
A case report on myxedema madness: curable psychosis. (24701017)
2014
7
Myxedema. (24931819)
2014
8
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013
9
Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease. (23514670)
2013
10
Myxedema coma in a patient with subclinical hypothyroidism. (21058937)
2011
11
Myxedema coma after esophagectomy. (20609804)
2010
12
Respiratory failure with myxedema ascites in a patient with idiopathic myxedema. (20847505)
2010
13
Myxedema associated with cardiac tamponade. (12825813)
2003
14
Myxedema ascites in the posttransplant setting: case report. (12410579)
2002
15
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
16
Cutis verticis gyrata secondary to hypothyroid myxedema. (10561054)
1999
17
Localized myxedema associated with diabetes mellitus. (9198327)
1997
18
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
19
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
20
Myxedema coma. Pathophysiology, therapy, and factors affecting prognosis. (7808091)
1995
21
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
22
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
23
Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies. (8100829)
1993
24
Osmoregulation of plasma vasopressin in myxedema. (2298864)
1990
25
Periorbital myxedema. (2909069)
1989
26
Cardiac enzyme changes in myxedema coma. (3829411)
1987
27
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. (3475916)
1987
28
Pathogenesis and treatment of pretibial myxedema. (3319589)
1987
29
Marrow myxedema. Gelatinous transformation of marrow ground substance in a patient with severe hypothyroidism. (2950837)
1987
30
Evolution of cardiorespiratory variables in myxedema coma--a case report. (3747964)
1986
31
Myxedema coma. (4093407)
1985
32
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy. (6640935)
1983
33
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
34
Pretibial myxedema. (7013714)
1981
35
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
36
Exit block in myxedema, treated effectively by thyroid hormone therapy. (6161358)
1980
37
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
38
Ventilatory control in myxedema and hypothyroidism. (1113761)
1975
39
Thyrotoxic crisis and myxedema coma. (4126972)
1973
40
Myxedema and myotonic dystrophy. (5008040)
1972
41
Myxedema ascites. (5268913)
1970
42
Post-therapeutic myxedema. (5782727)
1969
43
Graves' disease with pretibial myxedema. (5818149)
1969
44
Psychopathologic and metabolic changes in a patient with myxedema psychosis treated with L-tri-iodothyronine. (6021949)
1967
45
MYXEDEMA HEART DISEASE. (14275328)
1965
46
Localized myxedema involving the upper extremities. (14022010)
1963
47
Geriatric myxedema. (13892715)
1962
48
Dissociation of response to triiodothyroacetic acid in myxedema: comparison with response to thyroid substance. (13761052)
1961
49
Papular myxedema (papular mucinosis.). (13091390)
1953
50
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952

Variations for Myxedema

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Expression for genes affiliated with Myxedema

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Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

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GO Terms for genes affiliated with Myxedema

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Cellular components related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.2ATP6V1A, CTLA4, LGR6, TPO, TSHR
2extracellular spaceGO:00056157.9AVP, NPPA, SERPINA7, TG, TPO

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00065909.8TG, TPO
2hormone biosynthetic processGO:00424469.5TG, TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.5AVP, NPPA

Sources for Myxedema

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet