Aliases & Classifications for Myxedema

About this section
Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt
See all sources

Myxedema, Aliases & Descriptions:

Name: Myxedema 9 43 60
 
Myxoedema 9


External Ids:

Disease Ontology9 DOID:11634
MeSH33 D009230
NCIt38 C34834

Summaries for Myxedema

About this section


Wikipedia:63 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. It is also used to... more...

MalaCards based summary: Myxedema, also known as myxoedema, is related to hypothyroidism and graves' disease. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs thyroglobulin and thyroid (usp) and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Related Diseases for Myxedema

About this section

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism31.3TSHR, TPO, TG
2graves' disease30.9TSHR, CTLA4, TG, TPO
3thyrotoxicosis30.9TPO, TG, TSHR
4thyroiditis30.8CTLA4, CD79A, TSHR, TG, TPO
5goiter30.7TSHR, TG, TPO
6pernicious anemia30.6TPO, TG
7hyperthyroidism30.6CTLA4, TG, TPO, TSHR
8autoimmune thyroiditis30.5TPO, TG
9pericardial effusion30.5CHKB, MUC16
10congenital hypothyroidism30.4TPO, TG, TSHR
11rubella30.4CD79A
12nontoxic goiter30.2TSHR, TPO, TG
13tuberculosis30.1CD79A, TPO
14addison's disease30.0CTLA4, TPO, TG
15myocardial infarction29.6NPPA, CHKB, TPO
16congestive heart failure10.4AVP
17ovarian cystadenoma10.4MUC16
18hyperthyroxinemia10.4TPO, TSHR
19meningoencephalitis10.4CD79A
20acute poststreptococcal glomerulonephritis10.3CD79A
21hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.3TG, TSHR
22goiter, multinodular 1, with or without sertoli-leydig cell tumors10.3TG, TPO
23plummer's disease10.3TPO, TG
24thyroid carcinoma, follicular10.3TG, TSHR
25hypothryoidism, congenital, nongoitrous 410.3TG, TPO
26exophthalmos10.3
27premature ovarian failure10.3LGR6, TPO
28pendred syndrome10.3TG, TPO
29respiratory failure10.3
30turner syndrome10.3TG, TPO
31cardiac tamponade10.2
32subacute thyroiditis10.2TPO, TSHR, TG
33toxic diffuse goiter10.2TPO, TG, TSHR
34endemic goiter10.2TPO, TG, TSHR
35multinodular goiter10.2TG, TSHR, TPO
36thyroid adenoma10.2TG, TSHR, TPO
37thyroid cancer, anaplastic10.2TG, TSHR, TPO
38follicular adenoma10.2TSHR, TPO, TG
39thyroid carcinoma, papillary10.2TSHR, TG, TPO
40megacolon10.2
41myopathy10.2
42keratoderma10.2
43ataxia10.2
44ileus10.2
45thyroid cancer10.2TPO, TSHR, TG
46vitiligo-associated multiple autoimmune disease susceptibility 110.2CTLA4, TPO
47autoimmune hepatitis10.2CTLA4, TPO
48struma ovarii10.1TSHR, MUC16, TG
49pellagra10.1
50myasthenia gravis10.1

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms for Myxedema

About this section

Drugs & Therapeutics for Myxedema

About this section

Drug clinical trials:

Search ClinicalTrials for Myxedema

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Myxedema

About this section

Anatomical Context for Myxedema

About this section

MalaCards organs/tissues related to Myxedema:

31
Thyroid, Heart, Pituitary, Skin, Colon, Bone, Liver, Testes, Skeletal muscle, Brain, Kidney, Lung

Animal Models for Myxedema or affiliated genes

About this section

MGI Mouse Phenotypes related to Myxedema:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9CTLA4, CD79A, NPPA, TSHR, TG, TPO
2MP:00053766.8CTLA4, AVP, TPO, TG, CHKB, TSHR

Publications for Myxedema

About this section

Articles related to Myxedema:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Myxedema madness: a case for short-term antipsychotics? (25870443)
2015
2
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013
3
Myxedema coma in a patient with subclinical hypothyroidism. (21058937)
2011
4
Myxedema coma after esophagectomy. (20609804)
2010
5
Furosemide-induced recurrent syncope in myxedema. (15939116)
2005
6
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
7
Spontaneous bacterial peritonitis in a patient with myxedema ascites. (14581766)
2003
8
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
9
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
10
Cutis verticis gyrata secondary to hypothyroid myxedema. (10561054)
1999
11
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
12
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
13
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
14
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
15
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
16
Lithium toxicity and myxedema coma in an elderly woman. (2191030)
1990
17
Periorbital myxedema. (2909069)
1989
18
Beneficial effects of plasmapheresis followed by immunosuppressive therapy in pretibial myxedema. (3206977)
1988
19
Cardiac enzyme changes in myxedema coma. (3829411)
1987
20
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. (3475916)
1987
21
Pathogenesis and treatment of pretibial myxedema. (3319589)
1987
22
Evolution of cardiorespiratory variables in myxedema coma--a case report. (3747964)
1986
23
Myxedema coma. (4093407)
1985
24
Myxedema presenting as profound hypothermia-coma: a case report. (6589876)
1984
25
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy. (6640935)
1983
26
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
27
Pretibial myxedema. (7013714)
1981
28
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
29
Medical grand rounds: myxedema and the heart. (159279)
1979
30
Sinus arrest following diuretic therapy in a patient with myxedema and hypertension. (1240790)
1975
31
Myxedema ileus. A form of intestinal pseudo-obstruction. (1242154)
1975
32
Pretibial myxedema and nonthyrotoxic thyroid disease. (4118738)
1973
33
Myxedema and myotonic dystrophy. (5008040)
1972
34
Isolated TSH deficiency presenting as myxedema heart disease. (4253518)
1971
35
Reversible psychosis and dementia in myxedema. (4914345)
1970
36
Post-therapeutic myxedema. (5782727)
1969
37
The "cerebellar" signs of myxedema. (5775760)
1969
38
Corticoid therapy for pretibial myxedema. Observations on the long-acting thyroid stimulator. (4290292)
1967
39
Renal structure in myxedema. (6054612)
1967
40
Cardiomegaly in myxedema. Report of a case and review of the literature. (4223265)
1966
41
Goitrous myxedema with defect in iodide trapping and hormonogenesis. (5912549)
1966
42
MYXEDEMA HEART DISEASE. (14275328)
1965
43
MENSTRUAL PATTERNS IN MYXEDEMA. (14215872)
1964
44
MYXEDEMA COMA. (14130498)
1964
45
SEVERE DEPRESSION OF THE RESPIRATORY CENTER IN MYXEDEMA. (14162894)
1964
46
GOITROUS MYXEDEMA DUE TO IODIDE TRAPPING DEFECT. (14044820)
1963
47
Localized myxedema involving the upper extremities. (14022010)
1963
48
Mediastinal effusions in a case of pituitary myxedema. (13910857)
1962
49
Goiter and myxedema from iodine. (13690578)
1961
50
Papular myxedema (papular mucinosis.). (13091390)
1953

Variations for Myxedema

About this section

Expression for genes affiliated with Myxedema

About this section
Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

About this section

Compounds for genes affiliated with Myxedema

About this section

Compounds related to Myxedema according to GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1iodotyrosine43 2411.1TG, TPO
2diiodotyrosine4310.0TPO, TG
3sodium iodide439.9TSHR, TPO, TG
4propylthiouracil43 2 1211.9TG, TPO, TSHR
5125i439.9TSHR, TG, TPO
6iodide43 2410.9TPO, TSHR, TG
7methimazole43 2 1211.8TPO, TG, TSHR
8amiodarone43 49 28 1212.8TPO, TG, CHKB
9gliadin439.7TG, CD79A, TPO
10cardiolipin43 1210.6TG, TPO, CD79A
11isotretinoin43 1210.6CHKB, CD79A, TG
12selenium43 2410.5TG, CHKB, TPO
13triiodothyronine439.5TG, TPO, TSHR, CHKB
14iodine43 2410.5TSHR, TG, TPO, CTLA4
15thallium439.4TG, CHKB
16spec-t439.4CHKB, NPPA, TG
17uric acid43 2410.4CHKB, AVP, TPO
18salbutamol43 49 28 24 1213.2CD79A, NPPA, CHKB
19acth439.2TPO, AVP, TSHR, NPPA
20sialic acid439.2MUC16, TG, TSHR, CD79A
21sodium dodecylsulfate439.1CD79A, TPO, NPPA, TG
22ascorbic acid43 2410.1TG, CD79A, TPO, CHKB
23polyethylene glycol439.0CD79A, NPPA, TSHR, CHKB
24thyroxine43 2410.0CD79A, TSHR, CHKB, TG, TPO
25polysaccharide439.0TPO, TSHR, CHKB, TG, CD79A
26melphalan43 49 1211.0MUC16, CHKB, CD79A, CTLA4
27epinephrine43 24 1210.8NPPA, CHKB, CD79A, TG
28prednisolone43 28 1210.8CD79A, TSHR, CHKB, MUC16, TG
29fibrinogen438.8TPO, CHKB, MUC16, CD79A
30paraffin438.8CD79A, MUC16, CHKB, TSHR, TG
31acetylcholine43 49 28 24 1212.7CTLA4, TPO, TG, CD79A
32h2o2438.6TPO, TG, MUC16, CHKB, CD79A
33norepinephrine43 24 1210.6TG, CD79A, AVP, CHKB, NPPA
34adenylate438.6TSHR, CHKB, LGR6, TPO, TG
35cyclosporin a43 28 5910.5CHKB, NPPA, CD79A, CTLA4, TG
36alanine438.5TG, CHKB, AVP, TSHR, CTLA4, CD79A
37cholesterol43 28 24 1211.4TPO, CHKB, TSHR, CTLA4, LGR6
38sodium43 249.4AVP, MUC16, NPPA, TSHR, TPO, TG
39dexamethasone43 49 28 1211.4AVP, MUC16, CHKB, CD79A, CTLA4
40glutamate438.2AVP, TPO, TG, CHKB, TSHR, CD79A
41cysteine438.2AVP, CD79A, CTLA4, TPO, TG, CHKB
42vegf438.2NPPA, TSHR, CHKB, MUC16, TG, CD79A
43threonine438.1MUC16, CTLA4, LGR6, TSHR, AVP
44arginine438.0TPO, CD79A, NPPA, TG, TSHR, CHKB
45creatinine437.8CD79A, AVP, TPO, MUC16, CHKB, TG
46tyrosine437.7CTLA4, LGR6, MUC16, TSHR, TG, TPO
47serine437.7TG, TSHR, MUC16, LGR6, CTLA4, AVP
48steroid437.5CD79A, MUC16, CTLA4, AVP, TPO, CHKB
49testosterone43 59 24 1210.4CD79A, NPPA, MUC16, TG, TPO, CHKB
50estrogen436.9TSHR, CTLA4, CD79A, NPPA, TG, MUC16

GO Terms for genes affiliated with Myxedema

About this section

Cellular components related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.6CTLA4, LGR6, TSHR, TPO
2extracellular spaceGO:00056158.0NPPA, MUC16, TG, TPO, AVP

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.7TG, TPO
2thyroid hormone generationGO:00065909.5TG, TPO
3B cell receptor signaling pathwayGO:00508539.5CTLA4, CD79A

Products for genes affiliated with Myxedema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Myxedema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet