Aliases & Classifications for Myxedema

MalaCards integrated aliases for Myxedema:

Name: Myxedema 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11634
ICD10 33 E03.9
MeSH 42 D009230
NCIt 47 C34834
UMLS 69 C0027145

Summaries for Myxedema

MalaCards based summary : Myxedema is related to graves' disease and megaloblastic anemia-1, finnish type. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Allograft rejection and Insulin secretion. Affiliated tissues include thyroid, heart and pituitary.

Wikipedia : 72 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

Related Diseases for Myxedema

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
id Related Disease Score Top Affiliating Genes
1 graves' disease 11.2
2 megaloblastic anemia-1, finnish type 10.8
3 nodular lichen myxedematosus 10.8
4 hyperthyroidism, nonautoimmune 10.8
5 autoimmune polyendocrine syndrome, type ii 10.8
6 congenital hypothyroidism 10.8
7 glaucomatocyclitic crisis 10.4 CTLA4 TSHR
8 primary lacrimal atrophy 10.4 CTLA4 TSHR
9 thyroiditis 10.4
10 chronic polyneuropathy 10.3 TG TSHR
11 kidney disease 10.3 TG TSHR
12 panhypophysitis 10.3 TG TSHR
13 parachordoma 10.3 TG TSHR
14 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 10.3 TG TSHR
15 synovial chondromatosis 10.3 AVP NPPA
16 hypothyroidism 10.2
17 iridocyclitis 10.1 TG TSHR
18 adenohypophysitis 10.1 TG TPO
19 maxillary sinus adenoid cystic carcinoma 10.1 TG TPO
20 rhabdomyosarcoma, embryonal, 2 10.1 TG TPO
21 tick paralysis 10.0 TG TPO
22 chronic frontal sinusitis 10.0 TG TPO
23 lacrimal system cancer 10.0 CTLA4 TG TSHR
24 umbilical hernia 10.0 AVP CKB
25 exophthalmos 10.0
26 hypothyroidism, congenital, nongoitrous 4 10.0 TG TPO
27 hyperthyroidism 9.9
28 color blindness 9.9 TG TPO
29 heart disease 9.9
30 autoinflammation with arthritis and dyskeratosis 9.9 CTLA4 TPO
31 cardiac tamponade 9.9
32 c5 deficiency 9.9 TG TPO
33 respiratory failure 9.8
34 nephrogenic systemic fibrosis 9.8 TG TPO TSHR
35 goiter 9.8
36 background diabetic retinopathy 9.8 TG TPO TSHR
37 amelogenesis imperfecta, hypomaturation type, iia6 9.8 TG TPO TSHR
38 cerebral lipidosis 9.8 TG TPO TSHR
39 endemic goiter 9.8 TG TPO TSHR
40 lung occult large cell carcinoma 9.8 TG TPO TSHR
41 nodular prostate 9.8 TG TPO TSHR
42 meningovascular neurosyphilis 9.8 TG TPO TSHR
43 fibrolamellar carcinoma 9.8 TG TPO TSHR
44 bladder diffuse clear cell adenocarcinoma 9.8 TG TPO TSHR
45 primary bacterial infectious disease 9.8 TG TPO TSHR
46 gastrointestinal system cancer 9.8 TG TPO TSHR
47 megacolon 9.8
48 ataxia 9.8
49 pericardial effusion 9.8
50 myopathy 9.8

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to Myxedema

Symptoms & Phenotypes for Myxedema

Drugs & Therapeutics for Myxedema

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Lipid Metabolic Status in Thyroid Carcinoma Completed NCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

Anatomical Context for Myxedema

MalaCards organs/tissues related to Myxedema:

39
Thyroid, Heart, Pituitary, Skin, Colon, Testes, Bone

Publications for Myxedema

Articles related to Myxedema:

(show top 50) (show all 556)
id Title Authors Year
1
Myxedema coma: A case report of pediatric emergency care. ( 28538388 )
2017
2
Annularly arranged nodular pretibial myxedema after 7-year treatment of Graves' disease. ( 28150342 )
2017
3
Nivolumab induced myxedema crisis. ( 28239466 )
2017
4
Diagnosis of myxedema coma complicated by renal failure: a case report. ( 28396755 )
2017
5
Rapid Response to Loading Dose Levothyroxine in Myxedema Psychosis. ( 28102974 )
2017
6
Unusual Case of a Massive Macroglossia Secondary to Myxedema: A Case Report and Literature Review. ( 28742994 )
2017
7
Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion. ( 28670061 )
2017
8
Treatment of pretibial myxedema with intralesional immunomodulating therapy. ( 28932121 )
2017
9
Pretibial Myxedema Masquerading as a Venous Leg Ulcer. ( 28355140 )
2017
10
Intracerebral Bleeding and Massive Pericardial Effusion as Presenting Symptoms of Myxedema Crisis. ( 28255471 )
2017
11
Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan. ( 28142035 )
2017
12
Elephantiasic Pretibial Myxedema with Involvement of the Buttocks and Face. ( 28748868 )
2017
13
Myxedema Crisis Presenting with Seizures: A Rare Life-Threatening Presentation-A Case Report and Review of the Literature. ( 28540093 )
2017
14
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
15
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. ( 26924647 )
2016
16
Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. ( 27648339 )
2016
17
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. ( 27631398 )
2016
18
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. ( 27504447 )
2016
19
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). ( 27583414 )
2016
20
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. ( 28083456 )
2016
21
Periorbital Myxedema. ( 27802562 )
2016
22
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. ( 26873132 )
2016
23
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. ( 27872766 )
2016
24
Impending myxedema coma as the initial presentation of lung cancer. ( 27823924 )
2016
25
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India. ( 26019115 )
2015
26
Eczema craquelAc, an uncommon clinical manifestation of myxedema. ( 25918092 )
2015
27
A Randomized Controlled Trial of Intralesional Glucocorticoid for Treating Pretibial Myxedema. ( 26491499 )
2015
28
Myxedema madness complicating postoperative follow-up of thyroid cancer. ( 26331326 )
2015
29
A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS). ( 26155541 )
2015
30
Myxedema coma with cardiac tamponade and severe cardiomyopathy. ( 26424958 )
2015
31
Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. ( 26000037 )
2015
32
Images in clinical medicine. Myxedema. ( 25693016 )
2015
33
Dermoscopy of pretibial myxedema. ( 26568347 )
2015
34
Development of an objective tool for the diagnosis of myxedema coma. ( 25647622 )
2015
35
Myxedema madness: a case for short-term antipsychotics? ( 25870443 )
2015
36
Nodular Foot Myxedema Masquerading as Lymphedema. ( 26301146 )
2015
37
Computed tomography and magnetic resonance imaging findings of ureteral myxedema in Graves' disease. ( 25766333 )
2015
38
Pretibial myxedema. ( 26231090 )
2015
39
Pre-tibial myxedema: treatment with intralesional corticosteroid. ( 26312698 )
2015
40
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
41
Pretibial Myxedema: Case Presentation and Review of Treatment Options. ( 24807996 )
2014
42
A diagnostic scoring system for myxedema coma. ( 24518183 )
2014
43
Pretibial myxedema. ( 25184646 )
2014
44
Myxedema. ( 24931819 )
2014
45
A case report on myxedema madness: curable psychosis. ( 24701017 )
2014
46
Amiodarone-induced myxedema coma - a case and review of the literature. ( 25624868 )
2014
47
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. ( 26060688 )
2014
48
Dramatic effect of low-dose oral steroid on elephantiasic pretibial myxedema. ( 25200964 )
2014
49
Elephantiasic pretibial myxedema in a patient with graves disease that resolved after 131I treatment. ( 24830877 )
2014
50
Pretibial Myxedema Associated with Euthyroid Hashimoto's Thyroiditis: A Case Report. ( 25121051 )
2014

Variations for Myxedema

Expression for Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for Myxedema

GO Terms for Myxedema

Cellular components related to Myxedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 AVP CKB NPPA TPO

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cAMP biosynthetic process GO:0030819 9.16 AVP TSHR
2 regulation of blood vessel size GO:0050880 8.96 AVP NPPA
3 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 AVP NPPA
2 hormone activity GO:0005179 8.8 AVP NPPA TG

Sources for Myxedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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