MCID: MYX004
MIFTS: 50

Myxedema malady

Summaries for Myxedema

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Myxedema (British English: Myxoedema) is a term used synonymously with severe hypothyroidism. It is also... more...

MalaCards: Myxedema, also known as myxoedema, is related to thyroiditis and hypothyroidism. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Allograft rejection. The drugs thyroglobulin and thyroid (usp) and the compounds propylthiouracil and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 255900

Aliases & Classifications for Myxedema

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt
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Aliases & Descriptions:

myxedema 8 44 60
myxoedema 8


External Ids:

Disease Ontology8 DOID:11634
MeSH34 D009230
OMIM46 255900
NCIt39 C34834

Related Diseases for Myxedema

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17GeneCards, 18GeneDecks
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Diseases related to Myxedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.0CTLA4, CD79A, TSHR, TPO, TG
2hypothyroidism30.8TSHR, TPO, TG
3graves' disease30.8CTLA4, TSHR, TPO, TG
4hyperthyroidism30.4CTLA4, TSHR, TPO, TG
5thyrotoxicosis30.4TSHR, TPO, TG
6goiter30.2TSHR, TPO, TG
7myopathy30.2CHKB
8myasthenia gravis30.1CTLA4
9congenital hypothyroidism30.1TG, TPO, TSHR
10pericardial effusion30.1MUC16, CHKB
11diabetes mellitus30.1CD79A, CTLA4, NPPA
12pernicious anemia29.9TPO, TG
13autoimmune thyroiditis29.9TPO, TG
14diabetic ketoacidosis29.9CTLA4
15diabetes insipidus29.7AVP
16hepatitis29.7CTLA4
17lupus erythematosus29.7CD79A
18rubella29.7CD79A
19toxic diffuse goiter29.7TG, TPO, TSHR
20nontoxic goiter29.7TSHR, TPO, TG
21peritonitis29.7MUC16
22addison's disease29.7CTLA4, TPO, TG
23nephrotic syndrome29.7NPPA, CD79A
24myocardial infarction29.7TPO, CHKB, NPPA
25exophthalmos10.3
26respiratory failure10.2
27cardiac tamponade10.2
28hypertension10.1
29megacolon10.1
30pellagra10.1
31coronary artery disease10.0
32capgras syndrome10.0
33thyroid crisis10.0
34limb-girdle muscular dystrophy10.0
35hypoglycemia10.0
36adenocarcinoma10.0
37cerebellar ataxia10.0
38hyperparathyroidism10.0
39ischemia10.0
40muscular dystrophy10.0
41obesity10.0
42sarcoidosis10.0
43skin disease10.0
44myocarditis10.0CHKB
45thymoma10.0CTLA4
46subacute thyroiditis10.0TG
47bartter disease10.0AVP
48coronary heart disease10.0CHKB
49hyperthyroxinemia10.0TPO, TSHR
50congestive heart failure10.0AVP

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Clinical Features for Myxedema

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46OMIM
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Clinical features from OMIM:

255900

Drugs & Therapeutics for Myxedema

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myxedema

Drug clinical trials:

Search ClinicalTrials for Myxedema

Search NIH Clinical Center for Myxedema

Search CenterWatch for Myxedema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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32MalaCards
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MalaCards organs/tissues related to Myxedema:

32
Thyroid, Heart, Pituitary, Skin, Testes, Liver, Colon, Bone, Skeletal muscle, Kidney, Lung, Brain

Animal Models for Myxedema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TG, TPO, TSHR, AVP, CD79A, CHKB

Publications for Myxedema

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50PubMed
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Articles related to Myxedema:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Cancer and deliberate hypothyroidism, anesthesia, and myxedema coma: the curse of oncologic outcomes based on hypothyroidism. (23246983)
2013
2
Myxedema ascites with high CA-125: Case and a review of literature. (23646234)
2013
3
Localized myxedema of thyroid disease. (23680216)
2013
4
Respiratory failure with myxedema ascites in a patient with idiopathic myxedema. (20847505)
2010
5
Treatment of pretibial myxedema (PTM) with topical steroid ointment application with sealing cover (steroid occlusive dressing technique: steroid ODT) in Graves' patients. (20371956)
2010
6
Myxedema coma leading to respiratory depression in a dog. (15144105)
2004
7
Spontaneous bacterial peritonitis in a patient with myxedema ascites. (14581766)
2003
8
Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. (10707687)
2000
9
Factors associated with mortality of myxedema coma: report of eight cases and literature survey. (10646654)
1999
10
Myxedema coma. (7606694)
1995
11
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
12
Orbital decompression in Graves' ophthalmopathy associated with pretibial myxedema. (8370919)
1993
13
Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation. (1974269)
1990
14
Periorbital myxedema. (2909069)
1989
15
Myxedema coma associated with lithium therapy. (2773973)
1989
16
Euthyroid pretibial myxedema. (3812528)
1987
17
Primary myxedema with thyrotrophin-binding inhibitor immunoglobulins. Clinical and laboratory findings in 15 patients. (2860835)
1985
18
Pretibial myxedema associated with chronic thyroiditis. (3838429)
1985
19
Diagnosis of "myxedema madness". (3985205)
1985
20
Hyponatremia without inappropriate secretion of vasopressin in a case of myxedema coma. (7173113)
1982
21
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
22
Exit block in myxedema, treated effectively by thyroid hormone therapy. (6161358)
1980
23
Mechanisms of edema formation in myxedema--increased protein extravasation and relatively slow lymphatic drainage. (460364)
1979
24
Myxedema myopathy: a case report. (615716)
1977
25
Unusually high pacemaker threshold in severe myxedema. Decrease with thyroid hormone therapy. (975993)
1976
26
Treatment of myxedema and myxedema coma. (18747713)
1976
27
The successful treatment of myxedema and coronary artery disease in patients intolerant of thyroid hormone. (4548113)
1974
28
Mechanism of hyponatremia in myxedema. (4463823)
1974
29
A survival case of myxedema coma of pituitary origin. (4800918)
1973
30
Granulocytic leukemia associated with myxedema thyroiditis and myasthenia gravis. (4624232)
1972
31
Daily variations in plasma concentrations of tyrosine in thyrotoxicosis and myxedema. (5550305)
1971
32
Iodide induced myxedema: a failure of autoregulation. (5483847)
1970
33
Hypertension and myxedema. Case report and a review of the literature. (5264111)
1970
34
Myxedema masked by hypoparathyroidism following subtotal thyroidectomy. (5485237)
1970
35
Post-therapeutic myxedema. (5782727)
1969
36
Myxedema and ataxia. (5689677)
1968
37
Myxedema masquerading as tetany. (5714554)
1968
38
Pretibial myxedema. (6018846)
1967
39
Unusual thyroid disorders: localized myxedema; iodide goiter; secondary myxedema; neoplastic metastatis to the thyroid. (4227606)
1967
40
The relation between postheparin lipolytic activity and plasma triglyceride in myxedema. (5901772)
1966
41
RELENTLESS LOCALIZED MYXEDEMA, WITH EXOPHTHALMOS, CLUBBING OF THE FINGERS AND HYPERTROPHIC OSTEOARTHROPATHY: OBSERVATIONS ON AN UNUSUAL CASE. (14310013)
1965
42
Physiologic combinations of synthetic thyroid hormones in myxedema. (4158675)
1965
43
FUNCTIONAL PITUITARY TUMOR IN AN ADULT POSSIBLY SECONDARY TO LONG-STANDING MYXEDEMA. (14296260)
1965
44
TOPICAL FLUOCINOLONE WITH OCCLUSION IN PRETIBIAL MYXEDEMA. (14170604)
1964
45
DEAFNESS IN MYXEDEMA. (14216753)
1964
46
GOITROUS MYXEDEMA DUE TO IODIDE TRAPPING DEFECT. (14044820)
1963
47
Geriatric myxedema. (13892715)
1962
48
Myxedema with Erb's limb girdle muscular dystrophy. Report of a case with a review of the muscular abnormalities of myxedema. (13880763)
1962
49
Certain aspects of renal function in myxedema. (14483759)
1961
50
The metabolism of intravenously infused C14-labeled cholesterol in euthyroidism and myxedema. (13755282)
1961

Genetic Variations for Myxedema

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Expression for genes affiliated with Myxedema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxedema

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Pathways for genes affiliated with Myxedema

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29KEGG
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Pathways related to Myxedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9TG, TPO
2
Hide members
9.6TG, TPO, TSHR

Compounds for genes affiliated with Myxedema

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Myxedema according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.6TG
2cardiolipin44 1111.5TG
3iodotyrosine44 2411.3TPO, TG
4norepinephrine44 11 2412.2AVP, CHKB
5diiodotyrosine4410.2TG, TPO
6thallium4410.1TG, CHKB
7sodium iodide4410.1TG, TPO, TSHR
8125i4410.0TG, TPO, TSHR
9iodide44 2411.0TSHR, TPO, TG
10methimazole44 2 1111.9TSHR, TPO, TG
11carbimazole44 1110.9TPO, TSHR
12amiodarone44 49 28 1112.9CHKB, TPO, TG
13gliadin449.9CD79A, TPO, TG
14isotretinoin44 1110.8TG, CD79A, CHKB
15selenium44 2410.8CHKB, TPO, TG
16spec-t449.7NPPA, CHKB, TG
17triiodothyronine449.7CHKB, TSHR, TPO, TG
18iodine44 2410.7CTLA4, TSHR, TPO, TG
19salbutamol44 49 28 11 2413.6CD79A, CHKB, NPPA
20perchlorate449.6TG, TPO
21sodium44 2410.5MUC16, AVP, TPO, TG
22acth449.5TPO, TSHR, AVP, NPPA
23uric acid44 2410.4CHKB, AVP, TPO
24sodium dodecylsulfate449.4NPPA, CD79A, TPO, TG
25polyethylene glycol449.4NPPA, CHKB, CD79A, TSHR
26melphalan44 1110.4CD79A, MUC16, CHKB
27sialic acid449.4MUC16, CD79A, TSHR, TG
28ascorbic acid44 2410.3CHKB, CD79A, TPO, TG
29thyroxine44 2410.3CHKB, CD79A, TSHR, TPO, TG
30polysaccharide449.3TG, TPO, TSHR, CD79A, CHKB
31epinephrine44 11 2411.2TG, CD79A, CHKB, NPPA
32h2o2449.2CHKB, MUC16, CD79A, TPO
33acetylcholine44 49 28 11 2413.1TG, TPO, CD79A, CTLA4
34prednisolone44 28 1111.1CHKB, MUC16, CD79A, TSHR, TG
35adenylate449.1CHKB, LGR6, TSHR, TPO, TG
36fibrinogen449.0TPO, CD79A, MUC16, CHKB
37paraffin449.0CHKB, MUC16, CD79A, TSHR, TG
38cyclosporin a44 28 5910.9NPPA, CTLA4, CHKB, CD79A, TG
39cholesterol44 28 11 2411.8CTLA4, CHKB, LGR6, TSHR, TPO
40alanine448.8CTLA4, CHKB, CD79A, AVP, TSHR, TG
41glutamate448.6CTLA4, CHKB, CD79A, AVP, TSHR, TPO
42cysteine448.6CTLA4, CHKB, CD79A, AVP, TSHR, TPO
43dexamethasone44 49 28 1111.6CTLA4, CHKB, MUC16, CD79A, AVP
44vegf448.6NPPA, CHKB, MUC16, CD79A, TSHR, TG
45arginine448.5NPPA, CHKB, CD79A, AVP, TSHR, TPO
46creatinine448.3TG, TPO, AVP, CD79A, MUC16, CHKB
47tyrosine448.2CTLA4, MUC16, AVP, LGR6, TSHR, TPO
48steroid448.1CTLA4, CHKB, MUC16, CD79A, AVP, LGR6
49testosterone44 59 11 2411.1NPPA, CHKB, MUC16, CD79A, LGR6, TPO
50estrogen447.7NPPA, CTLA4, CHKB, MUC16, CD79A, LGR6

GO Terms for genes affiliated with Myxedema

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16Gene Ontology
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Biological processes related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.8TG, TPO
2B cell receptor signaling pathwayGO:0508539.7CD79A, CTLA4
3thyroid hormone generationGO:0065909.6TG, TPO

Products for genes affiliated with Myxedema

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Sources for Myxedema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet