MCID: MYX004
MIFTS: 53

Myxedema malady

Endocrine diseases category
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Summaries for Myxedema

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Myxedema (British English: Myxoedema) is a term used synonymously with severe hypothyroidism. It is also... more...

MalaCards: Myxedema, also known as myxoedema, is related to thyroiditis and hypothyroidism. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs thyroglobulin and thyroid (usp) and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Description from OMIM:47 255900

Aliases & Classifications for Myxedema

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8Disease Ontology, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 47OMIM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

myxedema 8 45 62
myxoedema 8


External Ids:

Disease Ontology8 DOID:11634
NCIt40 C34834
OMIM47 255900
MeSH35 D009230

Related Diseases for Myxedema

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17GeneCards, 18GeneDecks
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Diseases related to Myxedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.1CTLA4, CD79A, TSHR, TG, TPO
2hypothyroidism31.0TSHR, TPO, TG
3graves' disease30.9TSHR, CTLA4, TG, TPO
4thyrotoxicosis30.6TPO, TG, TSHR
5hyperthyroidism30.5CTLA4, TG, TPO, TSHR
6goiter30.4TSHR, TG, TPO
7pericardial effusion30.2CHKB, MUC16
8hypertension30.2AVP, NPPA, CD79A
9pernicious anemia30.2TPO, TG
10autoimmune thyroiditis30.2TPO, TG
11congenital hypothyroidism30.1TPO, TG, TSHR
12diabetes mellitus30.0CTLA4, NPPA, CD79A
13rubella29.9CD79A
14nontoxic goiter29.9TSHR, TPO, TG
15tuberculosis29.9CD79A, TPO
16addison's disease29.9CTLA4, TPO, TG
17myocardial infarction29.8NPPA, CHKB, TPO
18exophthalmos10.3
19respiratory failure10.3
20cardiac tamponade10.2
21megacolon10.2
22myopathy10.2
23ataxia10.2
24ileus10.2
25pellagra10.1
26myasthenia gravis10.1
27sleep apnea10.1
28keratoderma10.1
29congestive heart failure10.1AVP
30ovarian cystadenoma10.1MUC16
31hyperthyroxinemia10.1TPO, TSHR
32meningoencephalitis10.1CD79A
33acute poststreptococcal glomerulonephritis10.1CD79A
34thyroid agenesis10.1TG, TSHR
35plummer's disease10.1TPO, TG
36follicular thyroid carcinoma10.1TG, TSHR
37thyrotropin deficiency, isolated10.1TG, TPO
38premature ovarian failure10.1LGR6, TPO
39pendred syndrome10.1TG, TPO
40turner syndrome10.1TG, TPO
41pregnancy loss10.1TPO, TG
42subacute thyroiditis10.1TPO, TSHR, TG
43toxic diffuse goiter10.1TPO, TG, TSHR
44endemic goiter10.1TPO, TG, TSHR
45multinodular goiter10.1TG, TSHR, TPO
46thyroid adenoma10.0TG, TSHR, TPO
47thyroid cancer, anaplastic10.0TG, TSHR, TPO
48follicular adenoma10.0TSHR, TPO, TG
49type 1 diabetes mellitus10.0TPO, CTLA4
50papillary thyroid carcinoma10.0TSHR, TG, TPO

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms for Myxedema

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47OMIM
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Clinical features from OMIM:

255900

Drugs & Therapeutics for Myxedema

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Myxedema

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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33MalaCards
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MalaCards organs/tissues related to Myxedema:

33
Thyroid, Heart, Pituitary, Skin, Bone, Colon, Liver, Testes, Skeletal muscle, Kidney, Lung, Brain

Animal Models for Myxedema or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Myxedema:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9CTLA4, CD79A, NPPA, TSHR, TG, TPO
2MP:00053766.8CTLA4, AVP, TPO, TG, CHKB, TSHR

Publications for Myxedema

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52PubMed
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Articles related to Myxedema:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Myxedema coma in a patient with subclinical hypothyroidism. (21058937)
2011
2
Myxedema coma after esophagectomy. (20609804)
2010
3
Furosemide-induced recurrent syncope in myxedema. (15939116)
2005
4
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
5
Spontaneous bacterial peritonitis in a patient with myxedema ascites. (14581766)
2003
6
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
7
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
8
Cutis verticis gyrata secondary to hypothyroid myxedema. (10561054)
1999
9
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
10
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
11
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
12
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
13
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
14
Lithium toxicity and myxedema coma in an elderly woman. (2191030)
1990
15
Periorbital myxedema. (2909069)
1989
16
Beneficial effects of plasmapheresis followed by immunosuppressive therapy in pretibial myxedema. (3206977)
1988
17
Cardiac enzyme changes in myxedema coma. (3829411)
1987
18
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. (3475916)
1987
19
Pathogenesis and treatment of pretibial myxedema. (3319589)
1987
20
Evolution of cardiorespiratory variables in myxedema coma--a case report. (3747964)
1986
21
Myxedema coma. (4093407)
1985
22
Myxedema presenting as profound hypothermia-coma: a case report. (6589876)
1984
23
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy. (6640935)
1983
24
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
25
Pretibial myxedema. (7013714)
1981
26
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
27
Medical grand rounds: myxedema and the heart. (159279)
1979
28
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
29
Sinus arrest following diuretic therapy in a patient with myxedema and hypertension. (1240790)
1975
30
Myxedema ileus. A form of intestinal pseudo-obstruction. (1242154)
1975
31
Pretibial myxedema and nonthyrotoxic thyroid disease. (4118738)
1973
32
Myxedema and myotonic dystrophy. (5008040)
1972
33
Isolated TSH deficiency presenting as myxedema heart disease. (4253518)
1971
34
Reversible psychosis and dementia in myxedema. (4914345)
1970
35
Post-therapeutic myxedema. (5782727)
1969
36
The "cerebellar" signs of myxedema. (5775760)
1969
37
Graves' disease with pretibial myxedema. (5818149)
1969
38
Corticoid therapy for pretibial myxedema. Observations on the long-acting thyroid stimulator. (4290292)
1967
39
Renal structure in myxedema. (6054612)
1967
40
Cardiomegaly in myxedema. Report of a case and review of the literature. (4223265)
1966
41
Goitrous myxedema with defect in iodide trapping and hormonogenesis. (5912549)
1966
42
MYXEDEMA HEART DISEASE. (14275328)
1965
43
Myxedema and psychosis. (5852352)
1965
44
MENSTRUAL PATTERNS IN MYXEDEMA. (14215872)
1964
45
MYXEDEMA COMA. (14130498)
1964
46
SEVERE DEPRESSION OF THE RESPIRATORY CENTER IN MYXEDEMA. (14162894)
1964
47
Localized myxedema involving the upper extremities. (14022010)
1963
48
Mediastinal effusions in a case of pituitary myxedema. (13910857)
1962
49
Goiter and myxedema from iodine. (13690578)
1961
50
Papular myxedema (papular mucinosis.). (13091390)
1953

Variations for Myxedema

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Expression for genes affiliated with Myxedema

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 53QIAGEN
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Compounds for genes affiliated with Myxedema

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45Novoseek, 24HMDB, 3BitterDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Myxedema according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2411.1TG, TPO
2diiodotyrosine4510.0TPO, TG
3sodium iodide459.9TSHR, TPO, TG
4propylthiouracil45 3 1111.9TG, TPO, TSHR
5125i459.9TSHR, TG, TPO
6iodide45 2410.9TPO, TSHR, TG
7methimazole45 3 1111.8TPO, TG, TSHR
8amiodarone45 51 29 1112.8TPO, TG, CHKB
9gliadin459.7TG, CD79A, TPO
10cardiolipin45 1110.6TG, TPO, CD79A
11isotretinoin45 1110.6CHKB, CD79A, TG
12selenium45 2410.5TG, CHKB, TPO
13triiodothyronine459.5TG, TPO, TSHR, CHKB
14iodine45 2410.5TSHR, TG, TPO, CTLA4
15thallium459.4TG, CHKB
16spec-t459.4CHKB, NPPA, TG
17uric acid45 2410.4CHKB, AVP, TPO
18salbutamol45 51 29 24 1113.2CD79A, NPPA, CHKB
19acth459.2TPO, AVP, TSHR, NPPA
20sialic acid459.2MUC16, TG, TSHR, CD79A
21sodium dodecylsulfate459.1CD79A, TPO, NPPA, TG
22ascorbic acid45 2410.1TG, CD79A, TPO, CHKB
23polyethylene glycol459.0CD79A, NPPA, TSHR, CHKB
24thyroxine45 2410.0CD79A, TSHR, CHKB, TG, TPO
25polysaccharide459.0TPO, TSHR, CHKB, TG, CD79A
26melphalan45 51 1111.0MUC16, CHKB, CD79A, CTLA4
27epinephrine45 24 1110.8NPPA, CHKB, CD79A, TG
28prednisolone45 29 1110.8CD79A, TSHR, CHKB, MUC16, TG
29fibrinogen458.8TPO, CHKB, MUC16, CD79A
30paraffin458.8CD79A, MUC16, CHKB, TSHR, TG
31acetylcholine45 51 29 24 1112.7CTLA4, TPO, TG, CD79A
32h2o2458.6TPO, TG, MUC16, CHKB, CD79A
33norepinephrine45 24 1110.6TG, CD79A, AVP, CHKB, NPPA
34adenylate458.6TSHR, CHKB, LGR6, TPO, TG
35cyclosporin a45 29 6110.5CHKB, NPPA, CD79A, CTLA4, TG
36alanine458.5TG, CHKB, AVP, TSHR, CTLA4, CD79A
37cholesterol45 29 24 1111.4TPO, CHKB, TSHR, CTLA4, LGR6
38sodium45 249.4AVP, MUC16, NPPA, TSHR, TPO, TG
39dexamethasone45 51 29 1111.4AVP, MUC16, CHKB, CD79A, CTLA4
40glutamate458.2AVP, TPO, TG, CHKB, TSHR, CD79A
41cysteine458.2AVP, CD79A, CTLA4, TPO, TG, CHKB
42vegf458.2NPPA, TSHR, CHKB, MUC16, TG, CD79A
43threonine458.1MUC16, CTLA4, LGR6, TSHR, AVP
44arginine458.0TPO, CD79A, NPPA, TG, TSHR, CHKB
45creatinine457.8CD79A, AVP, TPO, MUC16, CHKB, TG
46tyrosine457.7CTLA4, LGR6, MUC16, TSHR, TG, TPO
47serine457.7TG, TSHR, MUC16, LGR6, CTLA4, AVP
48steroid457.5CD79A, MUC16, CTLA4, AVP, TPO, CHKB
49testosterone45 61 24 1110.4CD79A, NPPA, MUC16, TG, TPO, CHKB
50estrogen456.9TSHR, CTLA4, CD79A, NPPA, TG, MUC16

GO Terms for genes affiliated with Myxedema

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16Gene Ontology
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Cellular components related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.6CTLA4, LGR6, TSHR, TPO
2extracellular spaceGO:0056158.0NPPA, MUC16, TG, TPO, AVP

Biological processes related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.7TG, TPO
2thyroid hormone generationGO:0065909.5TG, TPO
3B cell receptor signaling pathwayGO:0508539.5CTLA4, CD79A

Products for genes affiliated with Myxedema

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  • Antibodies
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Sources for Myxedema

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet