MCID: MYX004
MIFTS: 50

Myxedema malady

Summaries for Myxedema

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Myxedema (British English: Myxoedema) is a term used synonymously with severe hypothyroidism. It is also... more...

MalaCards: Myxedema, also known as myxoedema, is related to thyroiditis and hypothyroidism. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Allograft rejection. The drugs thyroglobulin and thyroid (usp) and the compounds propylthiouracil and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 255900

Aliases & Classifications for Myxedema

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt
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Aliases & Descriptions:

myxedema 8 44 60
myxoedema 8


External Ids:

Disease Ontology8 DOID:11634
MeSH34 D009230
OMIM46 255900
NCIt39 C34834

Related Diseases for Myxedema

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17GeneCards, 18GeneDecks
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Diseases related to Myxedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.0CTLA4, CD79A, TSHR, TPO, TG
2hypothyroidism30.8TSHR, TPO, TG
3graves' disease30.8CTLA4, TSHR, TPO, TG
4hyperthyroidism30.4CTLA4, TSHR, TPO, TG
5thyrotoxicosis30.4TSHR, TPO, TG
6goiter30.2TSHR, TPO, TG
7myopathy30.2CHKB
8myasthenia gravis30.1CTLA4
9congenital hypothyroidism30.1TG, TPO, TSHR
10pericardial effusion30.1MUC16, CHKB
11diabetes mellitus30.1CD79A, CTLA4, NPPA
12pernicious anemia29.9TPO, TG
13autoimmune thyroiditis29.9TPO, TG
14diabetic ketoacidosis29.9CTLA4
15diabetes insipidus29.7AVP
16hepatitis29.7CTLA4
17lupus erythematosus29.7CD79A
18rubella29.7CD79A
19toxic diffuse goiter29.7TG, TPO, TSHR
20nontoxic goiter29.7TSHR, TPO, TG
21peritonitis29.7MUC16
22addison's disease29.7CTLA4, TPO, TG
23nephrotic syndrome29.7NPPA, CD79A
24myocardial infarction29.7TPO, CHKB, NPPA
25exophthalmos10.3
26respiratory failure10.2
27cardiac tamponade10.2
28hypertension10.1
29megacolon10.1
30pellagra10.1
31coronary artery disease10.0
32capgras syndrome10.0
33thyroid crisis10.0
34limb-girdle muscular dystrophy10.0
35hypoglycemia10.0
36adenocarcinoma10.0
37cerebellar ataxia10.0
38hyperparathyroidism10.0
39ischemia10.0
40muscular dystrophy10.0
41obesity10.0
42sarcoidosis10.0
43skin disease10.0
44myocarditis10.0CHKB
45thymoma10.0CTLA4
46subacute thyroiditis10.0TG
47bartter disease10.0AVP
48coronary heart disease10.0CHKB
49hyperthyroxinemia10.0TPO, TSHR
50congestive heart failure10.0AVP

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Clinical Features for Myxedema

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46OMIM
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Clinical features from OMIM:

255900

Drugs & Therapeutics for Myxedema

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myxedema

Drug clinical trials:

Search ClinicalTrials for Myxedema

Search NIH Clinical Center for Myxedema

Search CenterWatch for Myxedema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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32MalaCards
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MalaCards organs/tissues related to Myxedema:

32
Thyroid, Heart, Pituitary, Skin, Testes, Liver, Colon, Bone, Skeletal muscle, Kidney, Lung, Brain

Animal Models for Myxedema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TG, TPO, TSHR, AVP, CD79A, CHKB

Publications for Myxedema

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50PubMed
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Articles related to Myxedema:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Amenorrhea with myxedema: A hidden clue. (23776924)
2013
2
Ogilvie's syndrome in a case of myxedema coma. (22629518)
2012
3
Observing pretibial myxedema in patients with Graves' disease using digital infrared thermal imaging and high-resolution ultrasonography: for better records, early detection, and further investigation. (21266550)
2011
4
A review on post-puberty hypothyroidism: a glance at myxedema. (23350159)
2010
5
Nodular pretibial myxedema. (19061607)
2008
6
Hypothyroidism and myxedema coma. (17724938)
2007
7
"Superior rectus paralysis" due to inferior rectus myxedema. (17139131)
2006
8
Elephantiasic pretibial myxedema and cutis verticis gyrata caused by Graves' disease. (16910888)
2006
9
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
10
Elephantiasic pretibial myxedema in Graves' disease. (12583477)
2002
11
Plaque form of pretibial myxedema in hypothyroidism. (17664793)
2001
12
Pretibial myxedema. (11328639)
2001
13
Pretibial myxedema with Graves' disease: a case report and review of Japanese literature. (9609987)
1998
14
Treatment of myxedema coma for emergency surgery. (9459274)
1998
15
Localized myxedema associated with diabetes mellitus. (9198327)
1997
16
Myxedema. (9185111)
1997
17
Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies. (8100829)
1993
18
An unusual case of myxedema megacolon with features of ischemic and pseudomembranous colitis. (1548953)
1992
19
Myxedema coma. (1484632)
1992
20
Lithium toxicity and myxedema coma in an elderly woman. (2191030)
1990
21
Serum hyaluronan concentration determined by radiometric assay in patients with pretibial myxedema and Graves' ophthalmopathy. (1982261)
1990
22
Capgras' syndrome in a myxedema patient. (3557347)
1987
23
Emergency care of the patient with myxedema coma. (3540404)
1986
24
Thyroid storm and myxedema coma. (2865414)
1985
25
"Osler's sign": pretibial myxedema of Graves' disease. (3884118)
1985
26
Pretibial myxedema. (3993510)
1985
27
Natural history of primary myxedema. (3893125)
1985
28
Serum long acting thyroid stimulator (LATS) and LATS-protector (LATS-P) in Graves' disease associated with localized myxedema. (6547156)
1984
29
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
30
Preradial myxedema in thyroid disease. (6456700)
1981
31
Multifocal myxedema and mixed thyroid neoplasm in a dog. (7467066)
1981
32
Sinus arrest following diuretic therapy in a patient with myxedema and hypertension. (1240790)
1975
33
Renal response to sodium restriction in myxedema. (4841212)
1974
34
Hydrochlorothiazide-induced water intoxication in myxedema. (4479534)
1974
35
Reversible atrioventricular block in myxedema. (4695358)
1973
36
Comparative study of growth hormone response to hypoglycemia in normal subjects and in patients with primary myxedema or hyperthyroidism before and after treatment. (4706204)
1973
37
Adult myxedema--a hypocatabolic syndrome. (4729254)
1973
38
Lithium carbonate-induced myxedema. (4401588)
1972
39
Suppression of thyrotropin (h-TSH) in serums of patients with myxedema of varying etiology treated with thyroid hormones. (5109216)
1971
40
Rheumatic syndromes of myxedema. (5309661)
1970
41
The "cerebellar" signs of myxedema. (5775760)
1969
42
Myxedema and coronary artery disease--a comparative autopsy study. (5713917)
1968
43
Myxedema and hypertension. (5918906)
1966
44
Myxedema myopathy. Report of a case with response to therapy. (5974784)
1966
45
Myxedema and ataxia. Cerebellar alterations and "neural myxedema bodies". (5950589)
1966
46
The role of angiocardiography in myxedema heart disease. (14033206)
1963
47
Myxedema heart disease. Report of a case. (14000676)
1963
48
Semen analysis in myxedema. (13901787)
1962
49
Goiter and myxedema from iodine. (13690578)
1961
50
Myxedema heart disease and rheumatic heart disease. (13784813)
1961

Genetic Variations for Myxedema

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Expression for genes affiliated with Myxedema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxedema

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Pathways for genes affiliated with Myxedema

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29KEGG
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Pathways related to Myxedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TG, TPO
2
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9.6TG, TPO, TSHR

Compounds for genes affiliated with Myxedema

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44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Myxedema according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.6TG
2cardiolipin44 1111.5TG
3iodotyrosine44 2411.3TPO, TG
4norepinephrine44 11 2412.2AVP, CHKB
5diiodotyrosine4410.2TG, TPO
6thallium4410.1CHKB, TG
7sodium iodide4410.1TSHR, TPO, TG
8125i4410.0TPO, TG, TSHR
9iodide44 2411.0TPO, TSHR, TG
10methimazole44 2 1111.9TSHR, TPO, TG
11amiodarone44 49 28 1112.9CHKB, TPO, TG
12gliadin449.9TPO, CD79A, TG
13isotretinoin44 1110.8TG, CHKB, CD79A
14hypothiocyanite44 2410.8TPO, CD79A
15selenium44 2410.8CHKB, TG, TPO
16spec-t449.7CHKB, NPPA, TG
17triiodothyronine449.7CHKB, TSHR, TPO, TG
18iodine44 2410.7CTLA4, TPO, TG, TSHR
19salbutamol44 49 28 11 2413.6CD79A, NPPA, CHKB
20perchlorate449.6TPO, TG
21sodium44 2410.5MUC16, TG, TPO, AVP
22acth449.5TPO, AVP, NPPA, TSHR
23uric acid44 2410.4CHKB, TPO, AVP
24sodium dodecylsulfate449.4NPPA, TG, TPO, CD79A
25polyethylene glycol449.4NPPA, TSHR, CD79A, CHKB
26melphalan44 1110.4MUC16, CD79A, CHKB
27sialic acid449.4CD79A, MUC16, TSHR, TG
28ascorbic acid44 2410.3CD79A, TPO, TG, CHKB
29thyroxine44 2410.3CD79A, CHKB, TPO, TSHR, TG
30polysaccharide449.3CHKB, CD79A, TSHR, TG, TPO
31epinephrine44 11 2411.2CHKB, NPPA, CD79A, TG
32h2o2449.2CHKB, MUC16, CD79A, TPO
33acetylcholine44 49 28 11 2413.1CTLA4, TG, CD79A, TPO
34prednisolone44 28 1111.1CHKB, MUC16, TSHR, TG, CD79A
35adenylate449.1TPO, TG, TSHR, CHKB, LGR6
36fibrinogen449.0CHKB, MUC16, TPO, CD79A
37paraffin449.0CHKB, TG, CD79A, TSHR, MUC16
38cyclosporin a44 28 5910.9TG, CD79A, CTLA4, NPPA, CHKB
39cholesterol44 28 11 2411.8CTLA4, CHKB, LGR6, TSHR, TPO
40alanine448.8CHKB, CTLA4, TSHR, CD79A, TG, AVP
41glutamate448.6CTLA4, CHKB, CD79A, AVP, TG, TPO
42cysteine448.6CD79A, CHKB, AVP, TSHR, TPO, TG
43dexamethasone44 49 28 1111.6CHKB, AVP, CTLA4, MUC16, CD79A
44vegf448.6TG, MUC16, NPPA, CHKB, CD79A, TSHR
45arginine448.5TPO, TSHR, AVP, CD79A, TG, CHKB
46creatinine448.3CD79A, TPO, AVP, MUC16, CHKB, NPPA
47tyrosine448.2TG, CTLA4, MUC16, AVP, LGR6, TSHR
48steroid448.1CTLA4, CHKB, MUC16, CD79A, AVP, LGR6
49testosterone44 59 11 2411.1LGR6, TPO, CD79A, MUC16, CHKB, NPPA
50estrogen447.7TG, NPPA, CTLA4, CHKB, MUC16, CD79A

GO Terms for genes affiliated with Myxedema

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16Gene Ontology
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Biological processes related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.8TG, TPO
2B cell receptor signaling pathwayGO:0508539.7CD79A, CTLA4
3thyroid hormone generationGO:0065909.6TG, TPO

Products for genes affiliated with Myxedema

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  • Antibodies
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Sources for Myxedema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet