MCID: MYX004
MIFTS: 35

Myxedema malady

Category: Endocrine diseases

Aliases & Classifications for Myxedema

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Aliases & Descriptions for Myxedema:

Name: Myxedema 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:11634
ICD1030 E03.9
MeSH39 D009230
NCIt45 C34834

Summaries for Myxedema

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Wikipedia:71 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

MalaCards based summary: Myxedema is related to graves' disease and congenital hypothyroidism. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Rheumatoid arthritis and Insulin secretion. The drugs thyroid (usp) and liothyronine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary.

Related Diseases for Myxedema

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Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease11.2
2congenital hypothyroidism10.9
3megaloblastic anemia-1, finnish type10.8
4hyperthyroidism, nonautoimmune10.8
5autoimmune polyendocrine syndrome, type ii10.8
6nodular lichen myxedematosus10.8
7thyroiditis10.4
8hypothyroidism10.2
9primary lacrimal atrophy10.2CTLA4, TSHR
10acute hemorrhagic encephalitis10.1TG, TSHR
11gastrinoma10.1TG, TSHR
12mesocardia10.1TG, TSHR
13parachordoma10.1TG, TSHR
14syringomelia hyperkeratosis10.1AVP, NPPA
15neuronopathy, distal hereditary motor, type viia10.1TG, TSHR
16acute laryngitis10.0TG, TSHR
17exophthalmos10.0
18fibrous meningioma9.9TG, TPO
19hyperthyroidism9.9
20premature closure of the arterial duct9.9TG, TPO
21heart disease9.9
22tick paralysis9.9TG, TPO
23frontal sinusitis9.9TG, TPO
24caudal regression syndrome9.9TG, TPO
25nail disorder, nonsyndromic congenital, 79.9CTLA4, TPO
26color blindness9.9TG, TPO
27respiratory failure9.8
28cardiac tamponade9.8
29dysautonomia, familial9.8TG, TPO
30hypermobility syndrome9.8CTLA4, TPO
31neuhauser daly magnelli syndrome9.8TG, TPO, TSHR
32background diabetic retinopathy9.8TG, TPO, TSHR
33krabbe disease9.8TG, TPO, TSHR
34endemic goiter9.8TG, TPO, TSHR
35mixed eosinophil-basophil adenoma9.8TG, TPO, TSHR
36hypothyroidism, congenital, nongoitrous, 19.8TG, TPO, TSHR
37broad ligament malignant neoplasm9.8TG, TPO, TSHR
38nodular prostate9.8TG, TPO, TSHR
39exanthema subitum9.8TG, TPO, TSHR
40peritoneal serous papillary adenocarcinoma9.8TG, TPO, TSHR
41commensal bacterial infectious disease9.8TG, TPO, TSHR
42aflatoxins-related hepatocellular carcinoma9.8TG, TPO, TSHR
43otosclerosis9.8TG, TPO, TSHR
44choreoathetosis, hypothyroidism, and neonatal respiratory distress9.8TG, TPO, TSHR
45goiter9.8
46tenosynovitis of foot and ankle9.8TG, TPO, TSHR
47non-distal monosomy 10q9.8TG, TPO, TSHR
48muscular dystrophy-dystroglycanopathy , type a, 109.8TG, TPO, TSHR
49dihydrolipoamide dehydrogenase deficiency9.8TG, TPO
50cholesterol embolism9.8TG, TPO, TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms & Phenotypes for Myxedema

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Drugs & Therapeutics for Myxedema

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Lipid Metabolic Status in Thyroid CarcinomaCompletedNCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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MalaCards organs/tissues related to Myxedema:

36
Thyroid, Heart, Pituitary, Skin, Colon, Testes, Bone

Publications for Myxedema

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Articles related to Myxedema:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. (28055088)
2017
2
Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. (27648339)
2016
3
Impending myxedema coma as the initial presentation of lung cancer. (27823924)
2016
4
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. (28083456)
2016
5
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. (26873132)
2016
6
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. (27872766)
2016
7
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. (27504447)
2016
8
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). (27583414)
2016
9
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. (27631398)
2016
10
Periorbital Myxedema. (27802562)
2016
11
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. (26924647)
2016
12
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. (26137080)
2015
13
Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. (26000037)
2015
14
Computed tomography and magnetic resonance imaging findings of ureteral myxedema in Graves' disease. (25766333)
2015
15
A Randomized Controlled Trial of Intralesional Glucocorticoid for Treating Pretibial Myxedema. (26491499)
2015
16
A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS). (26155541)
2015
17
Dermoscopy of pretibial myxedema. (26568347)
2015
18
Myxedema madness complicating postoperative follow-up of thyroid cancer. (26331326)
2015
19
Eczema craquelAc, an uncommon clinical manifestation of myxedema. (25918092)
2015
20
Nodular Foot Myxedema Masquerading as Lymphedema. (26301146)
2015
21
Pretibial myxedema. (26231090)
2015
22
Myxedema coma with cardiac tamponade and severe cardiomyopathy. (26424958)
2015
23
Development of an objective tool for the diagnosis of myxedema coma. (25647622)
2015
24
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India. (26019115)
2015
25
Myxedema madness: a case for short-term antipsychotics? (25870443)
2015
26
Pre-tibial myxedema: treatment with intralesional corticosteroid. (26312698)
2015
27
Images in clinical medicine. Myxedema. (25693016)
2015
28
Pretibial Myxedema Associated with Euthyroid Hashimoto's Thyroiditis: A Case Report. (25121051)
2014
29
Pretibial myxedema. (25184646)
2014
30
Myxedema. (24931819)
2014
31
A case report on myxedema madness: curable psychosis. (24701017)
2014
32
Myxedema coma induced by short-term amiodarone therapy. (24521765)
2014
33
Heart failure presenting as myxedema coma: case report and review article. (24592692)
2014
34
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. (26060688)
2014
35
A diagnostic scoring system for myxedema coma. (24518183)
2014
36
Dramatic effect of low-dose oral steroid on elephantiasic pretibial myxedema. (25200964)
2014
37
Amiodarone-induced myxedema coma - a case and review of the literature. (25624868)
2014
38
Pretibial Myxedema: Case Presentation and Review of Treatment Options. (24807996)
2014
39
Elephantiasic pretibial myxedema in a patient with graves disease that resolved after 131I treatment. (24830877)
2014
40
Treatment of pretibial myxedema with dexamethazone injected subcutaneously by mesotherapy needles. (23397966)
2013
41
Myxedema ascites with high CA-125: Case and a review of literature. (23646234)
2013
42
Preradial myxedema in a euthyroid male: A distinct rarity. (24021369)
2013
43
Heart failure presenting as myxedema coma: case report and review article. (23691872)
2013
44
Amenorrhea with myxedema: A hidden clue. (23776924)
2013
45
Lithium toxicity and myxedema crisis in an elderly patient. (24910829)
2013
46
Myxedema coma: a sleeping giant in clinical practice. (24262739)
2013
47
Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease. (23514670)
2013
48
Severe hypothyroidism presenting as myxedema coma in the postoperative period in a patient taking sunitinib: case report and review of literature. (23246982)
2013
49
Localized myxedema of thyroid disease. (23680216)
2013
50
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013

Variations for Myxedema

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Expression for genes affiliated with Myxedema

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Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

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GO Terms for genes affiliated with Myxedema

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Cellular components related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.8ATP6V1A, CTLA4, LGR6, TPO, TSHR

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.1TG, TPO
2positive regulation of cAMP biosynthetic processGO:003081910.1AVP, TSHR
3regulation of blood vessel sizeGO:00508809.4AVP, NPPA

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5AVP, NPPA, TG
2neuropeptide hormone activityGO:00051849.4AVP, NPPA

Sources for Myxedema

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet