Myxedema malady

Wikipedia: Myxedema (BrE: myxoedema) describes a specific form of cutaneous and dermal edema secondary to increased...⁴⁴ more...

MalaCards: Myxedema, also known as myxedema (disorder), is related to congenital hypothyroidism and hypothyroidism. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways is Autoimmune thyroid disease. The drugs thyroglobulin and liothyronine and the compounds methimazole and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotype homeostasis/metabolism.

Aliases & Descriptions:

myxedema 6 8 32 43 myxedema (disorder) 6

myxoedema 6

Diseases related to myxedema by text searches and GeneDecks gene sharing:

(show top 50)    (show all 138)

id	Related Disease	Score	Top Affiliating Genes
1	congenital hypothyroidism	30.2	TG, TSHR, TPO
2	hypothyroidism	28.0	TG, TSHR, TPO
3	thyrotoxicosis	27.3	NPPA, TG, TSHR, TPO
4	thyroiditis	25.4	NPPA, TG, TSHR, CTLA4, TPO, CD79A
5	graves' disease	24.6	NPPA, TG, TSHR, CTLA4, TPO, CD79A
6	total iodide organification defect	13.4	TG, TPO
7	iodine hypothyroidism	13.4	TPO, TG
8	hashimoto's encephalitis	13.4	TPO, TG
9	megaloblastic anemia	13.4	TG, TPO
10	thyroid agenesis	13.4	TSHR, TG
11	premature menopause	13.4	TG, TPO
12	plummer's disease	13.4	TG, TPO
13	thyrotoxic periodic paralysis	13.3	TSHR, TPO
14	thyrotropin deficiency, isolated	13.3	TG, TPO
15	endogenous depression	13.3	TG, TPO
16	thyroid cancer, follicular	13.3	TG, TSHR
17	pendred syndrome	13.2	TG, TPO
18	limbic encephalitis	13.2	TG, TPO
19	premature ovarian failure	13.2	TPO, LGR6
20	autoimmune polyendocrine syndrome	13.2	TG, TPO
21	subacute thyroiditis	13.1	TG, TPO
22	hypothyroidism, autoimmune	13.1	CTLA4, TPO
23	toxic diffuse goiter	13.1	TG, TSHR, TPO
24	mucinoses	13.1	TPO, TSHR, TG
25	thyroid hormone metabolism	13.1	TPO, TG
26	neonatal hypothyroidism	13.1	TG, TSHR, TPO
27	nontoxic goiter	13.1	TG, TSHR, TPO
28	nodular goiter	13.1	TG, TSHR, TPO
29	thyroid cancer	13.1	TG, TSHR, TPO
30	anaplastic carcinoma	13.1	TPO, TSHR, TG
31	multinodular goiter	13.1	TPO, TSHR, TG
32	thyroid cancer, anaplastic	13.1	TG, TSHR, TPO
33	endemic goiter	13.1	TPO, TSHR, TG
34	thyroid medullary carcinoma	13.1	TG, TSHR, TPO
35	inappropriate adh syndrome	13.1	NPPA, AVP
36	thyroid adenoma	13.1	TPO, TSHR, TG
37	papillary thyroid carcinoma	13.1	TPO, TSHR, TG
38	petrositis	13.0	NPPA, AVP
39	pituitary apoplexy	13.0	NPPA, AVP
40	ovarian cystadenoma	13.0	LGR6, MUC16
41	sycp3-related pregnancy loss, susceptibility to	13.0	TG, TPO
42	enuresis	13.0	AVP, NPPA
43	abcb11-related intrahepatic cholestasis	12.9	NPPA, AVP
44	mayer-rokitansky-kuster-hauser syndrome	12.9	TG, TSHR, TPO
45	neuroectodermal endocrine syndrome	12.9	TG, TPO
46	ovarian cancer	12.9	TG, MUC16
47	pericardial effusion	12.8	MUC16, CHKB
48	struma ovarii	12.8	TG, TSHR, MUC16
49	paralysis	12.8	CHKB, TPO, TSHR
50	follicular adenoma	12.8	TPO, TG

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 levothyroxine, levothyroxine sodium, liothyronine, liothyronine sodium, thyroglobulin, thyroid, thyroid pwdr [va product], thyroid,bovine

MalaCards organs/tissues related to myxedema:

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MGI Mouse Phenotypes related to myxedema:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	6.9	CHKB, AVP, CD79A, TPO, CTLA4, TSHR

Articles related to myxedema:

(show all 13)

id	Title	Authors	Year	Affiliating Genes
1	Pretibial myxedema is associated with polymorphism in exon 1 of CTLA-4 gene in patients with Graves' ophthalmopathy. (19037649)	Khalilzadeh O.... Amirzargar A.	2009	CTLA4
2	Myxedema ascites with an extremely elevated CA125 Level: a case report. (17641444)	Kanehara H.... Tanaka N.	2007	MUC16
3	Pretibial myxedema: pathophysiology and treatment options. (16252929)	Fatourechi V.	2005	TSHR
4	Myxedema coma of both primary and secondary origin, with non-classic presentation and extremely elevated creatine kinase. (11014385)	Benvenga S.... Trimarchi F.	2000	CHKB
5	TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema. (9086563)	Stadlmayr W.... Heufelder A.E.	1997	TSHR
6	Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)	Tonacchera M.... Ludgate M.	1996	TPO, TG
7	Immunoglobulin A class fibroblast antibodies in patients with Graves' disease and pretibial myxedema. (8530579)	Arnold K.... Weetman A.P.	1995	TPO, CD79A
8	Preparation and characterization of monoclonal antith yrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyro id patients with primary myxedema. (7989462)	Okuda J.... Mori T.	1994	TSHR
9	Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies. (8100829)	Kosugi S.... Kohn L.D.	1993	TSHR
10	Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. (1349156)	Kosugi S.... Kohn L.D.	1992	TSHR, LGR6
11	Results of high-dose intravenous immunoglobulin treatment of patients with pretibial myxedema and Basedow's disease. Preliminary findings (1281765)	Antonelli A.... Baschieri L.	1992	TG
12	Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients. (1719963)	Kosugi S.... Kohn L.D.	1991	TSHR
13	Effect of acute water loading on plasma levels of antidiuretic hormone AVP aldosterone, ANP fractional excretion of sodium and plasma and urine osmolalities in myxedema. (2147645)	Bai Y.... Zhou X.Y.	1990	AVP, NPPA

Genes related to myxedema according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	TSHR	thyroid stimulating hormone receptor	11.0	Publications
2	LGR6	leucine-rich repeat containing G protein-coupled receptor 6	11.0	Publications
3	TPO	thyroid peroxidase	11.0	Publications
4	TG	thyroglobulin	11.0	Publications
5	MXD3	MAX dimerization protein 3	11.0	Disorders
6	AVP	arginine vasopressin	11.0	Publications
7	EFTUD1	elongation factor Tu GTP binding domain containing 1	11.0
8	CHKB	choline kinase beta	11.0	Publications
9	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
10	MUC16	mucin 16, cell surface associated	11.0	Publications
11	NPPA	natriuretic peptide A	11.0	Publications
12	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications

Pathways related to myxedema according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Autoimmune thyroid disease20	9.1	TPO, CTLA4, TSHR, TG

Compounds related to myxedema according to GeneDecks:

(show top 50)    (show all 72)

id	Compound	Score	Top Affiliating Genes
1	methimazole32 9 9	12.5	TSHR
2	iodotyrosine32 18	11.2	TPO, TG
3	diiodotyrosine32	10.2	TPO, TG
4	sodium iodide32	10.0	TPO, TSHR, TG
5	propylthiouracil32 9 9	12.0	TPO, TSHR, TG
6	thallium32	10.0	CHKB, TG
7	perchlorate32	10.0	TG, TPO
8	125i32	10.0	TG, TSHR, TPO
9	iodide32 18	11.0	TPO, TSHR, TG
10	carbimazole32 9 9	11.9	TSHR, TPO
11	amiodarone32 9 9	11.8	CHKB, TPO, TG
12	gliadin32	9.7	CD79A, TPO, TG
13	hypothiocyanite32 18	10.7	TPO, CD79A
14	selenium32 18	10.7	CHKB, TPO, TG
15	cardiolipin32 9 9	11.7	TG, TPO, CD79A
16	isotretinoin32 9 9	11.6	TG, CD79A, CHKB
17	triiodothyronine32	9.6	TG, TSHR, TPO, CHKB
18	iodine32 18	10.5	TPO, CTLA4, TSHR, TG
19	spec-t32	9.2	NPPA, TG, CHKB
20	adenylate32	9.1	TG, TSHR, TPO, CHKB, LGR6
21	sialic acid32	9.1	MUC16, CD79A, TSHR, TG
22	melphalan32 9 9	11.1	CHKB, MUC16, CD79A
23	ascorbic acid32 18	10.1	TG, TPO, CD79A, CHKB
24	thyroxine32 18	10.0	TG, TSHR, TPO, CD79A, CHKB
25	uric acid32 18	10.0	TPO, AVP, CHKB
26	salbutamol32 34 9 18 9	13.0	CHKB, CD79A, NPPA
27	polysaccharide32	9.0	TG, TSHR, TPO, CD79A, CHKB
28	acth32	9.0	AVP, TPO, TSHR, NPPA
29	sodium dodecylsulfate32	8.9	NPPA, TG, TPO, CD79A
30	polyethylene glycol32	8.8	NPPA, TSHR, CD79A, CHKB
31	acetylcholine32 9 18 9	11.8	CD79A, TPO, CTLA4, TG
32	cholesterol32 9 18 9	11.8	TSHR, CTLA4, TPO, CHKB, LGR6
33	prednisolone32 9 9	10.7	TG, TSHR, CD79A, MUC16, CHKB
34	paraffin32	8.7	TG, TSHR, CD79A, MUC16, CHKB
35	epinephrine32 9 18 9	11.6	NPPA, TG, CD79A, CHKB
36	fibrinogen32	8.5	CHKB, MUC16, CD79A, TPO
37	h2o232	8.5	TG, TPO, CD79A, MUC16, CHKB
38	norepinephrine32 9 18 9	11.4	NPPA, TG, CD79A, AVP, CHKB
39	alanine32	8.3	TG, TSHR, CTLA4, CD79A, AVP, CHKB
40	sodium32 18	9.2	NPPA, TG, TSHR, TPO, AVP, MUC16
41	cyclosporin a32 42	9.2	NPPA, TG, CTLA4, CD79A, CHKB
42	glutamate32	8.1	TG, TSHR, CTLA4, TPO, CD79A, AVP
43	cysteine32	8.1	TG, TSHR, CTLA4, TPO, CD79A, AVP
44	tyrosine32	8.0	TG, TSHR, CTLA4, TPO, AVP, MUC16
45	arginine32	7.8	NPPA, TG, TSHR, TPO, CD79A, AVP
46	steroid32	7.8	CTLA4, TPO, CD79A, AVP, MUC16, CHKB
47	vegf32	7.8	NPPA, TG, TSHR, CD79A, MUC16, CHKB
48	testosterone32 9 18 9	10.6	NPPA, TG, TPO, CD79A, MUC16, CHKB
49	creatinine32	7.5	NPPA, TG, TPO, CD79A, AVP, MUC16
50	estrogen32	7.1	NPPA, TG, TSHR, CTLA4, CD79A, MUC16

Biological processes related to myxedema according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:042446	9.6	TPO, TG
2	B cell receptor signaling pathway	GO:050853	9.4	CD79A, CTLA4