MCID: MYX004
MIFTS: 53

Myxedema malady

Endocrine diseases category

Summaries for Myxedema

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Wikipedia:64 Myxedema (British English: Myxoedema) is a term used synonymously with severe hypothyroidism. It is also... more...

MalaCards based summary: Myxedema, also known as myxoedema, is related to hypothyroidism and graves' disease. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs thyroglobulin and thyroid (usp) and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Description from OMIM:46 255900

Aliases & Classifications for Myxedema

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Sources:
9Disease Ontology, 44Novoseek, 61UMLS, 34MeSH, 46OMIM, 39NCIt, 56SNOMED-CT
See all sources

Myxedema, Aliases & Descriptions:

Name: Myxedema 9 44 61
 
Myxoedema 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:11634
MeSH34 D009230
OMIM46 255900
NCIt39 C34834

Related Diseases for Myxedema

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Diseases related to Myxedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism31.3TPO, TG, TSHR
2graves' disease30.9TPO, TG, TSHR, CTLA4
3thyrotoxicosis30.9TSHR, TG, TPO
4thyroiditis30.8TPO, TG, TSHR, CD79A, CTLA4
5goiter30.7TPO, TG, TSHR
6pernicious anemia30.6TPO, TG
7autoimmune thyroiditis30.5TG, TPO
8hyperthyroidism30.5TPO, TG, TSHR, CTLA4
9pericardial effusion30.5MUC16, CHKB
10congenital hypothyroidism30.4TPO, TG, TSHR
11rubella30.4CD79A
12nontoxic goiter30.2TPO, TG, TSHR
13tuberculosis30.1CD79A, TPO
14hypertension30.0AVP, NPPA, CD79A
15addison's disease30.0TPO, TG, CTLA4
16myocardial infarction29.6NPPA, CHKB, TPO
17diabetes mellitus29.6CTLA4, CD79A, NPPA
18congestive heart failure10.4AVP
19ovarian cystadenoma10.4MUC16
20hyperthyroxinemia10.4TSHR, TPO
21meningoencephalitis10.4CD79A
22acute poststreptococcal glomerulonephritis10.4CD79A
23thyroid agenesis10.4TSHR, TG
24plummer's disease10.3TPO, TG
25follicular thyroid carcinoma10.3TG, TSHR
26thyrotropin deficiency, isolated10.3TPO, TG
27premature ovarian failure10.3TPO, LGR6
28exophthalmos10.3
29pendred syndrome10.3TG, TPO
30turner syndrome10.3TG, TPO
31pregnancy loss10.3TPO, TG
32respiratory failure10.3
33cardiac tamponade10.2
34subacute thyroiditis10.2TSHR, TG, TPO
35toxic diffuse goiter10.2TPO, TG, TSHR
36endemic goiter10.2TSHR, TG, TPO
37multinodular goiter10.2TSHR, TG, TPO
38thyroid adenoma10.2TSHR, TG, TPO
39thyroid cancer, anaplastic10.2TPO, TG, TSHR
40follicular adenoma10.2TSHR, TG, TPO
41type 1 diabetes mellitus10.2CTLA4, TPO
42papillary thyroid carcinoma10.2TPO, TG, TSHR
43thyroid hurthle cell carcinoma10.2TSHR, TG, TPO
44megacolon10.2
45myopathy10.2
46keratoderma10.2
47ataxia10.2
48ileus10.2
49autoimmune hepatitis10.2TPO, CTLA4
50vitiligo10.2TPO, CTLA4

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms for Myxedema

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Clinical features from OMIM:

255900

Drugs & Therapeutics for Myxedema

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Drug clinical trials:

Search ClinicalTrials for Myxedema

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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MalaCards organs/tissues related to Myxedema:

32
Thyroid, Heart, Pituitary, Skin, Colon, Bone, Liver, Testes, Skeletal muscle, Brain, Kidney

Animal Models for Myxedema or affiliated genes

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MGI Mouse Phenotypes related to Myxedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9CTLA4, CD79A, NPPA, TSHR, TG, TPO
2MP:00053766.8CTLA4, AVP, TPO, TG, CHKB, TSHR

Publications for Myxedema

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Articles related to Myxedema:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
A case report on myxedema madness: curable psychosis. (24701017)
2014
2
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013
3
Myxedema coma in a patient with subclinical hypothyroidism. (21058937)
2011
4
Myxedema coma after esophagectomy. (20609804)
2010
5
Furosemide-induced recurrent syncope in myxedema. (15939116)
2005
6
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
7
Spontaneous bacterial peritonitis in a patient with myxedema ascites. (14581766)
2003
8
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
9
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
10
Cutis verticis gyrata secondary to hypothyroid myxedema. (10561054)
1999
11
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
12
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
13
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
14
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
15
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
16
Lithium toxicity and myxedema coma in an elderly woman. (2191030)
1990
17
Periorbital myxedema. (2909069)
1989
18
Beneficial effects of plasmapheresis followed by immunosuppressive therapy in pretibial myxedema. (3206977)
1988
19
Cardiac enzyme changes in myxedema coma. (3829411)
1987
20
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. (3475916)
1987
21
Pathogenesis and treatment of pretibial myxedema. (3319589)
1987
22
Evolution of cardiorespiratory variables in myxedema coma--a case report. (3747964)
1986
23
Myxedema coma. (4093407)
1985
24
Myxedema presenting as profound hypothermia-coma: a case report. (6589876)
1984
25
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy. (6640935)
1983
26
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
27
Pretibial myxedema. (7013714)
1981
28
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
29
Medical grand rounds: myxedema and the heart. (159279)
1979
30
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
31
Sinus arrest following diuretic therapy in a patient with myxedema and hypertension. (1240790)
1975
32
Myxedema ileus. A form of intestinal pseudo-obstruction. (1242154)
1975
33
Pretibial myxedema and nonthyrotoxic thyroid disease. (4118738)
1973
34
Myxedema and myotonic dystrophy. (5008040)
1972
35
Isolated TSH deficiency presenting as myxedema heart disease. (4253518)
1971
36
Reversible psychosis and dementia in myxedema. (4914345)
1970
37
Post-therapeutic myxedema. (5782727)
1969
38
The "cerebellar" signs of myxedema. (5775760)
1969
39
Corticoid therapy for pretibial myxedema. Observations on the long-acting thyroid stimulator. (4290292)
1967
40
Renal structure in myxedema. (6054612)
1967
41
Cardiomegaly in myxedema. Report of a case and review of the literature. (4223265)
1966
42
Goitrous myxedema with defect in iodide trapping and hormonogenesis. (5912549)
1966
43
MYXEDEMA HEART DISEASE. (14275328)
1965
44
MENSTRUAL PATTERNS IN MYXEDEMA. (14215872)
1964
45
MYXEDEMA COMA. (14130498)
1964
46
SEVERE DEPRESSION OF THE RESPIRATORY CENTER IN MYXEDEMA. (14162894)
1964
47
GOITROUS MYXEDEMA DUE TO IODIDE TRAPPING DEFECT. (14044820)
1963
48
Localized myxedema involving the upper extremities. (14022010)
1963
49
Goiter and myxedema from iodine. (13690578)
1961
50
Papular myxedema (papular mucinosis.). (13091390)
1953

Variations for Myxedema

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Expression for genes affiliated with Myxedema

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Expression patterns in normal tissues for genes affiliated with Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

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Compounds for genes affiliated with Myxedema

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Compounds related to Myxedema according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2511.1TG, TPO
2diiodotyrosine4410.0TPO, TG
3sodium iodide449.9TSHR, TPO, TG
4propylthiouracil44 3 1211.9TG, TPO, TSHR
5125i449.9TSHR, TG, TPO
6iodide44 2510.9TPO, TSHR, TG
7methimazole44 3 1211.8TPO, TG, TSHR
8amiodarone44 50 29 1212.8TPO, TG, CHKB
9gliadin449.7TG, CD79A, TPO
10cardiolipin44 1210.6TG, TPO, CD79A
11isotretinoin44 1210.6CHKB, CD79A, TG
12selenium44 2510.5TG, CHKB, TPO
13triiodothyronine449.5TG, TPO, TSHR, CHKB
14iodine44 2510.5TSHR, TG, TPO, CTLA4
15thallium449.4TG, CHKB
16spec-t449.4CHKB, NPPA, TG
17uric acid44 2510.4CHKB, AVP, TPO
18salbutamol44 50 29 25 1213.2CD79A, NPPA, CHKB
19acth449.2TPO, AVP, TSHR, NPPA
20sialic acid449.2MUC16, TG, TSHR, CD79A
21sodium dodecylsulfate449.1CD79A, TPO, NPPA, TG
22ascorbic acid44 2510.1TG, CD79A, TPO, CHKB
23polyethylene glycol449.0CD79A, NPPA, TSHR, CHKB
24thyroxine44 2510.0CD79A, TSHR, CHKB, TG, TPO
25polysaccharide449.0TPO, TSHR, CHKB, TG, CD79A
26melphalan44 50 1211.0MUC16, CHKB, CD79A, CTLA4
27epinephrine44 25 1210.8NPPA, CHKB, CD79A, TG
28prednisolone44 29 1210.8CD79A, TSHR, CHKB, MUC16, TG
29fibrinogen448.8TPO, CHKB, MUC16, CD79A
30paraffin448.8CD79A, MUC16, CHKB, TSHR, TG
31acetylcholine44 50 29 25 1212.7CTLA4, TPO, TG, CD79A
32h2o2448.6TPO, TG, MUC16, CHKB, CD79A
33norepinephrine44 25 1210.6TG, CD79A, AVP, CHKB, NPPA
34adenylate448.6TSHR, CHKB, LGR6, TPO, TG
35cyclosporin a44 29 6010.5CHKB, NPPA, CD79A, CTLA4, TG
36alanine448.5TG, CHKB, AVP, TSHR, CTLA4, CD79A
37cholesterol44 29 25 1211.4TPO, CHKB, TSHR, CTLA4, LGR6
38sodium44 259.4AVP, MUC16, NPPA, TSHR, TPO, TG
39dexamethasone44 50 29 1211.4AVP, MUC16, CHKB, CD79A, CTLA4
40glutamate448.2AVP, TPO, TG, CHKB, TSHR, CD79A
41cysteine448.2AVP, CD79A, CTLA4, TPO, TG, CHKB
42vegf448.2NPPA, TSHR, CHKB, MUC16, TG, CD79A
43threonine448.1MUC16, CTLA4, LGR6, TSHR, AVP
44arginine448.0TPO, CD79A, NPPA, TG, TSHR, CHKB
45creatinine447.8CD79A, AVP, TPO, MUC16, CHKB, TG
46tyrosine447.7CTLA4, LGR6, MUC16, TSHR, TG, TPO
47serine447.7TG, TSHR, MUC16, LGR6, CTLA4, AVP
48steroid447.5CD79A, MUC16, CTLA4, AVP, TPO, CHKB
49testosterone44 60 25 1210.4CD79A, NPPA, MUC16, TG, TPO, CHKB
50estrogen446.9TSHR, CTLA4, CD79A, NPPA, TG, MUC16

GO Terms for genes affiliated with Myxedema

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Cellular components related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.6CTLA4, LGR6, TSHR, TPO
2extracellular spaceGO:0056158.0NPPA, MUC16, TG, TPO, AVP

Biological processes related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.7TG, TPO
2thyroid hormone generationGO:0065909.5TG, TPO
3B cell receptor signaling pathwayGO:0508539.5CTLA4, CD79A

Products for genes affiliated with Myxedema

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Sources for Myxedema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet