Aliases & Classifications for Myxedema

About this section

Aliases & Descriptions for Myxedema:

Name: Myxedema 11 13 48 37 66
 
Myxoedema 11

Classifications:



External Ids:

Disease Ontology11 DOID:11634
ICD1028 E03.9
MeSH37 D009230
NCIt43 C34834

Summaries for Myxedema

About this section
Wikipedia:69 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

MalaCards based summary: Myxedema, also known as myxoedema, is related to congenital hypothyroidism and autoimmune polyendocrine syndrome, type ii, and has symptoms including umbilical discharge, osler's node and abnormal granulation tissue. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways is Thyroxine (Thyroid Hormone) Production. The drugs thyroglobulin and thyroid (usp) have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skin.

Related Diseases for Myxedema

About this section

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1congenital hypothyroidism11.1
2autoimmune polyendocrine syndrome, type ii10.9
3nodular lichen myxedematosus10.9
4graves' disease10.8
5thyroiditis10.5
6peptic esophagitis10.4CTLA4, TSHR
7hypothyroidism10.4
8pseudomarfanism10.3AVP, NPPA
9acute liver failure10.3AVP, NPPA
10demyelinating polyneuropathy10.3TG, TSHR
11malignant syringoma10.2TG, TSHR
12crohn's disease of the esophagus10.2TG, TSHR
13acquired central diabetes insipidus10.2TG, TSHR
14benign mesothelioma10.2TG, TSHR
15substernal goiter10.1TG, TSHR
16exophthalmos10.1
17glaucomatocyclitic crisis10.1TG, TSHR
18hyperthyroidism10.1
19meningovascular neurosyphilis10.1TG, TSHR
20heart disease10.0
21primary bacterial infectious disease10.0TG, TSHR
22respiratory failure10.0
23cardiac tamponade10.0
24hereditary conventional renal cell carcinoma9.9CTLA4, TG, TSHR
25hashimoto thyroiditis9.9CTLA4, TG, TSHR
26blood group incompatibility9.9CTLA4, TG, TSHR
27goiter9.9
28intermittent proptosis9.9CTLA4, TG, TSHR
29megaloblastic anemia-1, finnish type9.9
30hyperthyroidism, nonautoimmune9.9
31kidney benign neoplasm9.9TG, TSHR
32frontotemporal dementia and/or amyotrophic lateral sclerosis 49.9TG, TSHR
33megacolon9.9
34myopathy9.9
35ataxia9.9
36myasthenia gravis9.8
37sleep apnea9.8
38pericardial effusion9.8
39cardiogenic shock9.8
40richter's syndrome9.8TG, TSHR
41craniopharyngioma9.8AVP, SERPINA7
42coronary artery disease9.7
43obesity9.7
44artery disease9.7
45obstructive sleep apnea9.7
46limb-girdle muscular dystrophy9.7
47pernicious anemia9.7
48hyperparathyroidism9.7
49adenocarcinoma9.7
50ischemia9.7

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms for Myxedema

About this section

UMLS symptoms related to Myxedema:


umbilical discharge, osler's node, abnormal granulation tissue, hard edema, skin symptom

Drugs & Therapeutics for Myxedema

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Lipid Metabolic Status in Thyroid CarcinomaCompletedNCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

About this section

Anatomical Context for Myxedema

About this section

MalaCards organs/tissues related to Myxedema:

34
Thyroid, Heart, Skin, Pituitary, Colon, Testes, Liver

Animal Models for Myxedema or affiliated genes

About this section

Publications for Myxedema

About this section

Articles related to Myxedema:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. (26924647)
2016
2
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). (27583414)
2016
3
A case report on myxedema madness: curable psychosis. (24701017)
2014
4
Myxedema. (24931819)
2014
5
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013
6
Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease. (23514670)
2013
7
Myxedema coma in a patient with subclinical hypothyroidism. (21058937)
2011
8
Myxedema coma after esophagectomy. (20609804)
2010
9
Respiratory failure with myxedema ascites in a patient with idiopathic myxedema. (20847505)
2010
10
Myxedema associated with cardiac tamponade. (12825813)
2003
11
Myxedema ascites in the posttransplant setting: case report. (12410579)
2002
12
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
13
Cutis verticis gyrata secondary to hypothyroid myxedema. (10561054)
1999
14
Localized myxedema associated with diabetes mellitus. (9198327)
1997
15
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
16
Early onset pretibial myxedema in the absence of ophthalmopathy: a morphologic evolution. (8886536)
1996
17
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
18
Myxedema coma. Pathophysiology, therapy, and factors affecting prognosis. (7808091)
1995
19
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
20
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
21
Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies. (8100829)
1993
22
Osmoregulation of plasma vasopressin in myxedema. (2298864)
1990
23
Periorbital myxedema. (2909069)
1989
24
Role of blocking TSH receptor antibodies on the development of hypothyroidism and thyroid atrophy in primary myxedema. (2577255)
1989
25
Cardiac enzyme changes in myxedema coma. (3829411)
1987
26
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. (3475916)
1987
27
Pathogenesis and treatment of pretibial myxedema. (3319589)
1987
28
Marrow myxedema. Gelatinous transformation of marrow ground substance in a patient with severe hypothyroidism. (2950837)
1987
29
Evolution of cardiorespiratory variables in myxedema coma--a case report. (3747964)
1986
30
Myxedema coma. (4093407)
1985
31
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy. (6640935)
1983
32
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
33
Pretibial myxedema. (7013714)
1981
34
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
35
Exit block in myxedema, treated effectively by thyroid hormone therapy. (6161358)
1980
36
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
37
Ventilatory control in myxedema and hypothyroidism. (1113761)
1975
38
Thyrotoxic crisis and myxedema coma. (4126972)
1973
39
Myxedema and myotonic dystrophy. (5008040)
1972
40
Myxedema ascites. (5268913)
1970
41
Post-therapeutic myxedema. (5782727)
1969
42
Graves' disease with pretibial myxedema. (5818149)
1969
43
Psychopathologic and metabolic changes in a patient with myxedema psychosis treated with L-tri-iodothyronine. (6021949)
1967
44
MYXEDEMA HEART DISEASE. (14275328)
1965
45
Localized myxedema involving the upper extremities. (14022010)
1963
46
The electrocardiogram as an aid in the diagnosis of myxedema. (13975327)
1963
47
Geriatric myxedema. (13892715)
1962
48
Dissociation of response to triiodothyroacetic acid in myxedema: comparison with response to thyroid substance. (13761052)
1961
49
Papular myxedema (papular mucinosis.). (13091390)
1953
50
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952

Variations for Myxedema

About this section

Expression for genes affiliated with Myxedema

About this section
Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

About this section

Pathways related to Myxedema according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7TG, TSHR

GO Terms for genes affiliated with Myxedema

About this section

Cellular components related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1AVP, CKB, NPPA, SERPINA7, TG

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.7AVP, NPPA

Sources for Myxedema

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet