MCID: MYX004
MIFTS: 49

Myxedema malady

Summaries for Myxedema

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Myxedema (British English: Myxoedema) is a term used synonymously with severe hypothyroidism. It is also... more...

MalaCards: Myxedema, also known as myxoedema, is related to graves' disease and thyrotoxicosis. An important gene associated with Myxedema is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Allograft rejection. The drugs thyroglobulin and thyroid (usp) and the compounds propylthiouracil and cardiolipin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:47 255900

Aliases & Classifications for Myxedema

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 47OMIM, 40NCIt
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Aliases & Descriptions:

myxedema 8 45 61
myxoedema 8


External Ids:

Disease Ontology8 DOID:11634
MeSH35 D009230
OMIM47 255900
NCIt40 C34834

Related Diseases for Myxedema

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myxedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease30.8CTLA4, TSHR, TPO, TG
2thyrotoxicosis30.4TSHR, TPO, TG
3thyroiditis30.4CTLA4, CD79A, TSHR, TPO, TG
4pernicious anemia30.0TPO, TG
5congenital hypothyroidism30.0TG, TPO, TSHR
6diabetic ketoacidosis29.9CTLA4
7turner syndrome29.9TPO, TG
8diabetes insipidus29.8AVP
9rubella29.8CD79A
10thyrotropin deficiency, isolated29.8TPO, TG
11down syndrome29.8TPO, TSHR
12toxic diffuse goiter29.8TG, TPO, TSHR
13nontoxic goiter29.8TSHR, TPO, TG
14exophthalmos10.3
15cardiac tamponade10.2
16ataxia10.2
17ileus10.2
18pellagra10.1
19keratoderma10.1
20myotonia10.1
21sleep apnea10.1
22cardiogenic shock10.1
23coronary artery disease,10.0
24capgras syndrome10.0
25thyroid crisis10.0
26limb-girdle muscular dystrophy10.0
27hypoglycemia10.0
28adenocarcinoma10.0
29cutis verticis gyrata10.0
30hypercholesterolemia10.0
31myocarditis10.0CHKB
32myasthenia gravis10.0CTLA4
33thymoma10.0CTLA4
34subacute thyroiditis10.0TG
35bartter disease10.0AVP
36hepatitis10.0CTLA4
37coronary heart disease10.0CHKB
38hyperthyroxinemia10.0TPO, TSHR
39congestive heart failure10.0AVP
40candidiasis10.0CD79A
41ovarian cystadenoma10.0MUC16
42autoimmune thyroiditis10.0TPO, TG
43mumps10.0CD79A
44thyroid agenesis10.0TSHR, TG
45lupus erythematosus10.0CD79A
46plummer's disease10.0TPO, TG
47neuropathy10.0CD79A
48follicular thyroid carcinoma10.0TSHR, TG
49galactosemia10.0CD79A
50glomerulonephritis10.0CD79A

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Clinical Features for Myxedema

Sources:
47OMIM
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Clinical features from OMIM:

255900

Drugs & Therapeutics for Myxedema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Myxedema

Drug clinical trials:

Search ClinicalTrials for Myxedema

Search NIH Clinical Center for Myxedema

Search CenterWatch for Myxedema

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Myxedema

Anatomical Context for Myxedema

Sources:
33MalaCards
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MalaCards organs/tissues related to Myxedema:

33
Skin, Liver, Brain, Kidney, Lung, Bone marrow, Heart, Skeletal muscle, Colon, Thyroid, Adrenal gland, Pituitary

Animal Models for Myxedema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Myxedema:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TG, TPO, TSHR, AVP, CD79A, CHKB

Publications for Myxedema

Sources:
51PubMed
See all sources

Articles related to Myxedema:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease. (23514670)
2013
2
Ogilvie's syndrome in a case of myxedema coma. (22629518)
2012
3
Chorea--an unusual manifestation in a woman recovering from myxedema coma. (22232025)
2012
4
Treatment of pretibial myxedema (PTM) with topical steroid ointment application with sealing cover (steroid occlusive dressing technique: steroid ODT) in Graves' patients. (20371956)
2010
5
Papulosis mucinosis versus atypical tuberous myxedema of Dossekker. (20676483)
2010
6
Nodular pretibial myxedema. (19061607)
2008
7
Myxedema coma. (12766541)
2003
8
Recombinant monoclonal thyrotropin-stimulation blocking antibody (TSBAb) established from peripheral lymphocytes of a hypothyroid patient with primary myxedema. (15008244)
2003
9
Plaque form of pretibial myxedema in hypothyroidism. (17664793)
2001
10
Pretibial myxedema. (11328639)
2001
11
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
12
Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. (10707687)
2000
13
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
14
Early onset pretibial myxedema in the absence of ophthalmopathy: a morphologic evolution. (8886536)
1996
15
Preradial myxedema: a case report. (8799023)
1996
16
Myxedema coma. Pathophysiology, therapy, and factors affecting prognosis. (7808091)
1995
17
An unusual case of myxedema megacolon with features of ischemic and pseudomembranous colitis. (1548953)
1992
18
Thyroid disease in the emergency department. Thyroid function tests and hypothyroidism and myxedema coma. (2680470)
1989
19
Role of blocking TSH receptor antibodies on the development of hypothyroidism and thyroid atrophy in primary myxedema. (2577255)
1989
20
Thyroid hormone-induced reduction of urinary 5-hydroxyindole acetic acid (5 HIAA) in obese children. Comparison with hypothyroid patients of similar age having either pituitary dwarfism or congenital myxedema. (2474192)
1989
21
The relationship of hypercholesterolemia to atherosclerosis with particular emphasis on familial hypercholesterolemia, diabetes mellitus, obstructive jaundice, myxedema, and the nephrotic syndrome. (3275991)
1988
22
Cardiac enzyme changes in myxedema coma. (3829411)
1987
23
Capgras' syndrome in a myxedema patient. (3557347)
1987
24
Graves' autoantibodies to extrathyroidal TSH receptor: their role in ophthalmopathy and pretibial myxedema. (3475915)
1987
25
Thyroid storm and myxedema coma. (2865414)
1985
26
Preradial myxedema in thyroid disease. (6456700)
1981
27
Myxedema psychosis--insanity defense in homicide. (7410326)
1980
28
Mechanisms of myxedema formation. (7351962)
1980
29
Mechanisms of edema formation in myxedema--increased protein extravasation and relatively slow lymphatic drainage. (460364)
1979
30
Primary myxedema heart disease. (722831)
1978
31
Rheumatic manifestations in myxedema. (1088319)
1976
32
Echocardiographic evaluation of pericardial effusion in myxedema. Incidence and biochemical and clinical correlations. (126121)
1975
33
Pretibial myxedema and nonthyrotoxic thyroid disease. (4118738)
1973
34
Iodide myxedema with facial swelling simulating angioneurotic edema. (5280561)
1971
35
Localized pretibial myxedema and thyroid acropachy in a case of Hurthle cell adenocarcinoma. (4940290)
1971
36
Graves' disease with pretibial myxedema. (5818149)
1969
37
Posttherapeutic myxedema. Relative occurrence after treatment of hyperthyroidism by radioactive iodine (131-I) or subtotal thyroidectomy. (4169814)
1968
38
Neurologic manifestations of myxedema. (5704907)
1968
39
Renal structure in myxedema. (6054612)
1967
40
Therapy with occlusive dressings of pretibial myxedema with fluocinolone acetonide. (5337857)
1967
41
Scleromyxedema. A variant of Lichen myxedematosus. (4221381)
1966
42
Myxedema and psychosis. (5852352)
1965
43
AN ORAL TYROSINE TOLERANCE TEST IN THYROTOXICOSIS AND MYXEDEMA. (14284982)
1965
44
DIABETES MELLITUS, ADDISON'S DISEASE AND MYXEDEMA--REPORT OF TWO CASES. (14264246)
1965
45
PRETIBIAL MYXEDEMA. REPORT OF A CASE. (14323202)
1965
46
MENSTRUAL PATTERNS IN MYXEDEMA. (14215872)
1964
47
Myxedema with Erb's limb girdle muscular dystrophy. Report of a case with a review of the muscular abnormalities of myxedema. (13880763)
1962
48
Paroxysmal ventricular tachycardia associated with myxedema. A case report. (13711338)
1961
49
Therapy of circumscribed myxedema. (13789283)
1961
50
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952

Genetic Variations for Myxedema

Expression for genes affiliated with Myxedema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxedema

Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

Sources:
30KEGG
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Pathways related to Myxedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TG, TPO
2
Hide members
9.6TG, TPO, TSHR

Compounds for genes affiliated with Myxedema

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Myxedema according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1propylthiouracil45 2 1112.6TG
2cardiolipin45 1111.5TG
3iodotyrosine45 2411.3TPO, TG
4norepinephrine45 11 2412.2AVP, CHKB
5diiodotyrosine4510.2TG, TPO
6thallium4510.1TG, CHKB
7sodium iodide4510.1TG, TPO, TSHR
8125i4510.0TG, TPO, TSHR
9iodide45 2411.0TSHR, TPO, TG
10methimazole45 2 1111.9TSHR, TPO, TG
11carbimazole45 1110.9TPO, TSHR
12amiodarone45 50 29 1112.9CHKB, TPO, TG
13gliadin459.9CD79A, TPO, TG
14isotretinoin45 1110.8TG, CD79A, CHKB
15selenium45 2410.8CHKB, TPO, TG
16spec-t459.7NPPA, CHKB, TG
17triiodothyronine459.7CHKB, TSHR, TPO, TG
18iodine45 2410.7CTLA4, TSHR, TPO, TG
19salbutamol45 50 29 11 2413.6CD79A, CHKB, NPPA
20perchlorate459.6TG, TPO
21sodium45 2410.5MUC16, AVP, TPO, TG
22acth459.5TPO, TSHR, AVP, NPPA
23uric acid45 2410.4CHKB, AVP, TPO
24sodium dodecylsulfate459.4NPPA, CD79A, TPO, TG
25polyethylene glycol459.4NPPA, CHKB, CD79A, TSHR
26melphalan45 1110.4CD79A, MUC16, CHKB
27sialic acid459.4MUC16, CD79A, TSHR, TG
28ascorbic acid45 2410.3CHKB, CD79A, TPO, TG
29thyroxine45 2410.3CHKB, CD79A, TSHR, TPO, TG
30polysaccharide459.3TG, TPO, TSHR, CD79A, CHKB
31epinephrine45 11 2411.2TG, CD79A, CHKB, NPPA
32h2o2459.2CHKB, MUC16, CD79A, TPO
33acetylcholine45 50 29 11 2413.1TG, TPO, CD79A, CTLA4
34prednisolone45 29 1111.1CHKB, MUC16, CD79A, TSHR, TG
35adenylate459.1CHKB, LGR6, TSHR, TPO, TG
36fibrinogen459.0TPO, CD79A, MUC16, CHKB
37paraffin459.0CHKB, MUC16, CD79A, TSHR, TG
38cyclosporin a45 29 6010.9NPPA, CTLA4, CHKB, CD79A, TG
39cholesterol45 29 11 2411.8CTLA4, CHKB, LGR6, TSHR, TPO
40alanine458.8CTLA4, CHKB, CD79A, AVP, TSHR, TG
41glutamate458.6CTLA4, CHKB, CD79A, AVP, TSHR, TPO
42cysteine458.6CTLA4, CHKB, CD79A, AVP, TSHR, TPO
43dexamethasone45 50 29 1111.6CTLA4, CHKB, MUC16, CD79A, AVP
44vegf458.6NPPA, CHKB, MUC16, CD79A, TSHR, TG
45arginine458.5NPPA, CHKB, CD79A, AVP, TSHR, TPO
46creatinine458.3TG, TPO, AVP, CD79A, MUC16, CHKB
47tyrosine458.2CTLA4, MUC16, AVP, LGR6, TSHR, TPO
48steroid458.1CTLA4, CHKB, MUC16, CD79A, AVP, LGR6
49testosterone45 60 11 2411.1NPPA, CHKB, MUC16, CD79A, LGR6, TPO
50estrogen457.7NPPA, CTLA4, CHKB, MUC16, CD79A, LGR6

GO Terms for genes affiliated with Myxedema

Sources:
16Gene Ontology
See all sources

Biological processes related to Myxedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.8TG, TPO
2B cell receptor signaling pathwayGO:0508539.7CD79A, CTLA4
3thyroid hormone generationGO:0065909.6TG, TPO

Products for genes affiliated with Myxedema

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  • Antibodies

Sources for Myxedema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet