Aliases & Classifications for Myxedema

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Aliases & Descriptions for Myxedema:

Name: Myxedema 10 47 12 36 65
 
Myxoedema 10

Classifications:



External Ids:

Disease Ontology10 DOID:11634
ICD1027 E03.9
MeSH36 D009230
NCIt42 C34834
UMLS65 C0027145

Summaries for Myxedema

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Wikipedia:68 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. It is also used to... more...

MalaCards based summary: Myxedema, also known as myxoedema, is related to thyroiditis and autoimmune thyroiditis, and has symptoms including skin symptom, hard edema and abnormal granulation tissue. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs thyroid (beef) and thyroglobulin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and breast.

Related Diseases for Myxedema

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Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.4TG, TPO, TSHR
2autoimmune thyroiditis29.8TG, TPO
3goiter29.7SERPINA7, TG
4papilledema27.3CTLA4, SERPINA7, TG, TPO, TSHR
5congenital hypothyroidism11.1
6autoimmune polyglandular syndrome type 210.9
7nodular lichen myxedematosus10.9
8graves' disease10.8
9hypothyroidism10.3
10chronic inflammatory demyelinating polyradiculoneuropathy10.3TG, TSHR
11female breast lower-outer quadrant cancer10.3CTLA4, TSHR
12iatrogenic or traumatic pituitary deficiency10.3TG, TSHR
13perivascular epithelioid cell tumor10.3TG, TSHR
14syngap1-related non-syndromic intellectual disability10.3AVP, NPPA
15fuchs' heterochromic uveitis10.2TG, TSHR
16thyroid ectopia10.1TG, TPO
17neonatal meningitis10.1TG, TPO
18rhabdomyosarcoma, embryonal, 210.1TG, TPO
19exophthalmos10.1
20hyperthyroidism10.1
21solar retinopathy10.0TG, TPO
22heart disease10.0
23setariasis10.0TG, TPO
24hypothryoidism, congenital, nongoitrous 410.0TG, TPO
25megaloblastic anemia10.0TG, TPO
26respiratory failure10.0
27cardiac tamponade10.0
28glaucoma, primary open angle, juvenile-onset, 29.9TG, TPO
29megaloblastic anemia-1, finnish type9.9
30hyperthyroidism, nonautoimmune9.9
31plantar wart9.9CTLA4, TPO
32adult acute lymphocytic leukemia9.9CKB, NPPA
33megacolon9.9
34myopathy9.9
35ataxia9.9
36bone cancer9.9TG, TPO
37pituitary adenoma9.9AVP, SERPINA7
38deafness, autosomal recessive 4, with enlarged vestibular aqueduct9.8TG, TPO
39corneal intraepithelial dyskeratosis and ectodermal dysplasia9.8CTLA4, TPO
40myasthenia gravis9.8
41sleep apnea9.8
42pericardial effusion9.8
43cardiogenic shock9.8
44lingual goiter9.8TG, TPO, TSHR
45endemic goiter9.8TG, TPO, TSHR
46parenchymatous neurosyphilis9.8TG, TPO, TSHR
47mediastinal osteogenic sarcoma9.8TG, TPO, TSHR
48hypophosphatemia9.8TG, TPO, TSHR
49familial abdominal aortic aneurysm9.8TG, TPO, TSHR
50frontotemporal dementia and/or amyotrophic lateral sclerosis 49.8TG, TPO, TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms for Myxedema

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UMLS symptoms related to Myxedema:


skin symptom, hard edema, abnormal granulation tissue, osler's node, umbilical discharge

Drugs & Therapeutics for Myxedema

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Lipid Metabolic Status in Thyroid CarcinomaCompletedNCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

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Anatomical Context for Myxedema

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MalaCards organs/tissues related to Myxedema:

33
Thyroid, Heart, Breast, Pituitary, Liver, Lung, Bone

Animal Models for Myxedema or affiliated genes

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Publications for Myxedema

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Articles related to Myxedema:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. (26924647)
2016
2
Myxedema madness: a case for short-term antipsychotics? (25870443)
2015
3
A case report on myxedema madness: curable psychosis. (24701017)
2014
4
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013
5
Myxedema coma in a patient with subclinical hypothyroidism. (21058937)
2011
6
Myxedema coma after esophagectomy. (20609804)
2010
7
Furosemide-induced recurrent syncope in myxedema. (15939116)
2005
8
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
9
Spontaneous bacterial peritonitis in a patient with myxedema ascites. (14581766)
2003
10
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
11
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
12
Cutis verticis gyrata secondary to hypothyroid myxedema. (10561054)
1999
13
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
14
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
15
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
16
Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema. (7989462)
1994
17
Treatment of myxedema-associated cardiogenic shock. (8512169)
1993
18
Lithium toxicity and myxedema coma in an elderly woman. (2191030)
1990
19
Periorbital myxedema. (2909069)
1989
20
Beneficial effects of plasmapheresis followed by immunosuppressive therapy in pretibial myxedema. (3206977)
1988
21
Cardiac enzyme changes in myxedema coma. (3829411)
1987
22
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase. (3475916)
1987
23
Pathogenesis and treatment of pretibial myxedema. (3319589)
1987
24
Evolution of cardiorespiratory variables in myxedema coma--a case report. (3747964)
1986
25
Myxedema coma. (4093407)
1985
26
Myxedema presenting as profound hypothermia-coma: a case report. (6589876)
1984
27
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy. (6640935)
1983
28
Polysomnographic effects of thyroid hormones primary myxedema. (6177500)
1982
29
Pretibial myxedema. (7013714)
1981
30
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
31
Medical grand rounds: myxedema and the heart. (159279)
1979
32
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
33
Sinus arrest following diuretic therapy in a patient with myxedema and hypertension. (1240790)
1975
34
Pretibial myxedema and nonthyrotoxic thyroid disease. (4118738)
1973
35
Myxedema and myotonic dystrophy. (5008040)
1972
36
Isolated TSH deficiency presenting as myxedema heart disease. (4253518)
1971
37
Reversible psychosis and dementia in myxedema. (4914345)
1970
38
Post-therapeutic myxedema. (5782727)
1969
39
The "cerebellar" signs of myxedema. (5775760)
1969
40
Corticoid therapy for pretibial myxedema. Observations on the long-acting thyroid stimulator. (4290292)
1967
41
Renal structure in myxedema. (6054612)
1967
42
Cardiomegaly in myxedema. Report of a case and review of the literature. (4223265)
1966
43
MYXEDEMA HEART DISEASE. (14275328)
1965
44
MENSTRUAL PATTERNS IN MYXEDEMA. (14215872)
1964
45
MYXEDEMA COMA. (14130498)
1964
46
SEVERE DEPRESSION OF THE RESPIRATORY CENTER IN MYXEDEMA. (14162894)
1964
47
GOITROUS MYXEDEMA DUE TO IODIDE TRAPPING DEFECT. (14044820)
1963
48
Localized myxedema involving the upper extremities. (14022010)
1963
49
Goiter and myxedema from iodine. (13690578)
1961
50
Papular myxedema (papular mucinosis.). (13091390)
1953

Variations for Myxedema

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Expression for genes affiliated with Myxedema

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Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

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GO Terms for genes affiliated with Myxedema

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Biological processes related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00065909.7TG, TPO
2hormone biosynthetic processGO:00424469.4TG, TPO

Sources for Myxedema

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet