Aliases & Classifications for Myxedema

About this section

Aliases & Descriptions for Myxedema:

Name: Myxedema 11 50 39 13 68
 
Myxoedema 11

Classifications:



External Ids:

Disease Ontology11 DOID:11634
ICD1030 E03.9
MeSH39 D009230
NCIt45 C34834

Summaries for Myxedema

About this section
Wikipedia:71 Myxedema or myxoedema is a term used synonymously with severe hypothyroidism. However, the term is also... more...

MalaCards based summary: Myxedema, also known as myxoedema, is related to pericarditis and hashimoto thyroiditis, and has symptoms including umbilical discharge, osler's node and abnormal granulation tissue. An important gene associated with Myxedema is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs thyroid (usp) and triiodothyronine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skin.

Related Diseases for Myxedema

About this section

Diseases related to Myxedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis28.7TG, TPO, TSHR
2hashimoto thyroiditis28.4CTLA4, TG, TPO, TSHR
3graves' disease11.2
4congenital hypothyroidism10.9
5megaloblastic anemia-1, finnish type10.8
6hyperthyroidism, nonautoimmune10.8
7autoimmune polyendocrine syndrome, type ii10.8
8nodular lichen myxedematosus10.8
9thyroiditis10.4
10peptic esophagitis10.3CTLA4, TSHR
11pseudomarfanism10.3AVP, NPPA
12demyelinating polyneuropathy10.3TG, TSHR
13malignant syringoma10.3TG, TSHR
14acquired central diabetes insipidus10.3TG, TSHR
15benign mesothelioma10.3TG, TSHR
16hypothyroidism10.2
17acute liver failure10.2AVP, NPPA
18substernal goiter10.2TG, TSHR
19glaucomatocyclitic crisis10.1TG, TSHR
20tinea corporis10.1SERPINA7, TG
21cerebral lipidosis10.1SERPINA7, TG
22iatrogenic or traumatic pituitary deficiency10.1TG, TPO
23ovarian endometrioid cystadenoma10.0TG, TPO
24rhabdomyosarcoma, embryonal, 210.0TG, TPO
25lung occult adenocarcinoma10.0SERPINA7, TG
26peripheral scars of retina10.0TG, TPO
27craniopharyngioma10.0AVP, SERPINA7
28exophthalmos10.0
29chronic frontal sinusitis10.0TG, TPO
30hyperthyroidism9.9
31hypothryoidism, congenital, nongoitrous 49.9TG, TPO
32heart disease9.9
33hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia9.9SERPINA7, TG, TSHR
34nail disorder, nonsyndromic congenital, 79.9CTLA4, TPO
35respiratory failure9.9
36cardiac tamponade9.9
37dysautonomia, familial9.8TG, TPO
38goiter9.8
39crohn's disease of the esophagus9.8TG, TPO, TSHR
40meningovascular neurosyphilis9.8TG, TPO, TSHR
41primary bacterial infectious disease9.8TG, TPO, TSHR
42kidney benign neoplasm9.8TG, TPO, TSHR
43deafness, autosomal recessive 4, with enlarged vestibular aqueduct9.8TG, TPO
44atrial standstill9.8TG, TPO, TSHR
45frontotemporal dementia and/or amyotrophic lateral sclerosis 49.8TG, TPO, TSHR
46megacolon9.8
47myopathy9.8
48ataxia9.8
49chorea, hereditary benign9.7TG, TPO, TSHR
50richter's syndrome9.7TG, TSHR

Graphical network of the top 20 diseases related to Myxedema:



Diseases related to myxedema

Symptoms & Phenotypes for Myxedema

About this section

UMLS symptoms related to Myxedema:


umbilical discharge, osler's node, abnormal granulation tissue, hard edema, skin symptom

Drugs & Therapeutics for Myxedema

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Lipid Metabolic Status in Thyroid CarcinomaCompletedNCT01487057

Search NIH Clinical Center for Myxedema

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: myxedema

Genetic Tests for Myxedema

About this section

Anatomical Context for Myxedema

About this section

MalaCards organs/tissues related to Myxedema:

36
Thyroid, Heart, Skin, Pituitary, Colon, Testes, Bone

Publications for Myxedema

About this section

Articles related to Myxedema:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. (28055088)
2017
2
A rabbit model of fatal hypothyroidism mimicking "myxedema coma" established by microscopic total thyroidectomy. (26924647)
2016
3
Impending myxedema coma as the initial presentation of lung cancer. (27823924)
2016
4
Periorbital Myxedema. (27802562)
2016
5
Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia"). (27583414)
2016
6
An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure. (27872766)
2016
7
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema. (27504447)
2016
8
Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. (27648339)
2016
9
Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. (28083456)
2016
10
Polypoid and fungating form of elephantiasic pretibial myxedema with involvement of the hands. (26873132)
2016
11
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics. (27631398)
2016
12
Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. (26000037)
2015
13
Computed tomography and magnetic resonance imaging findings of ureteral myxedema in Graves' disease. (25766333)
2015
14
Pretibial myxedema. (26231090)
2015
15
Development of an objective tool for the diagnosis of myxedema coma. (25647622)
2015
16
Eczema craquelAc, an uncommon clinical manifestation of myxedema. (25918092)
2015
17
Pre-tibial myxedema: treatment with intralesional corticosteroid. (26312698)
2015
18
Myxedema madness complicating postoperative follow-up of thyroid cancer. (26331326)
2015
19
Myxedema madness: a case for short-term antipsychotics? (25870443)
2015
20
Dermoscopy of pretibial myxedema. (26568347)
2015
21
A Randomized Controlled Trial of Intralesional Glucocorticoid for Treating Pretibial Myxedema. (26491499)
2015
22
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India. (26019115)
2015
23
Images in clinical medicine. Myxedema. (25693016)
2015
24
Nodular Foot Myxedema Masquerading as Lymphedema. (26301146)
2015
25
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. (26137080)
2015
26
A Rare Case of Myxedema Coma with Neuroleptic Malignant Syndrome (NMS). (26155541)
2015
27
Myxedema coma with cardiac tamponade and severe cardiomyopathy. (26424958)
2015
28
A case report on myxedema madness: curable psychosis. (24701017)
2014
29
Myxedema. (24931819)
2014
30
Heart failure presenting as myxedema coma: case report and review article. (24592692)
2014
31
Dramatic effect of low-dose oral steroid on elephantiasic pretibial myxedema. (25200964)
2014
32
Elephantiasic pretibial myxedema in a patient with graves disease that resolved after 131I treatment. (24830877)
2014
33
Pretibial Myxedema: Case Presentation and Review of Treatment Options. (24807996)
2014
34
Myxedema coma induced by short-term amiodarone therapy. (24521765)
2014
35
Amiodarone-induced myxedema coma - a case and review of the literature. (25624868)
2014
36
Pretibial Myxedema Associated with Euthyroid Hashimoto's Thyroiditis: A Case Report. (25121051)
2014
37
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. (26060688)
2014
38
Pretibial myxedema. (25184646)
2014
39
A diagnostic scoring system for myxedema coma. (24518183)
2014
40
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. (24557975)
2013
41
Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease. (23514670)
2013
42
Thyroid gland disorder emergencies: thyroid storm and myxedema coma. (23880755)
2013
43
Treatment of pretibial myxedema with dexamethazone injected subcutaneously by mesotherapy needles. (23397966)
2013
44
Heart failure presenting as myxedema coma: case report and review article. (23691872)
2013
45
Myxedema ascites with high CA-125: Case and a review of literature. (23646234)
2013
46
Preradial myxedema in a euthyroid male: A distinct rarity. (24021369)
2013
47
Lithium toxicity and myxedema crisis in an elderly patient. (24910829)
2013
48
Localized myxedema of thyroid disease. (23680216)
2013
49
Severe hypothyroidism presenting as myxedema coma in the postoperative period in a patient taking sunitinib: case report and review of literature. (23246982)
2013
50
Cancer and deliberate hypothyroidism, anesthesia, and myxedema coma: the curse of oncologic outcomes based on hypothyroidism. (23246983)
2013

Variations for Myxedema

About this section

Expression for genes affiliated with Myxedema

About this section
Search GEO for disease gene expression data for Myxedema.

Pathways for genes affiliated with Myxedema

About this section

GO Terms for genes affiliated with Myxedema

About this section

Cellular components related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7AVP, NPPA, SERPINA7, TG, TPO
2integral component of plasma membraneGO:00058878.2ATP6V1A, CTLA4, LGR6, TPO, TSHR

Biological processes related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.0TG, TPO
2thyroid hormone generationGO:00065909.8TG, TPO

Molecular functions related to Myxedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.5AVP, NPPA

Sources for Myxedema

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet