MCID: MYX013
MIFTS: 40

Myxofibrosarcoma malady

Neuronal diseases, Cancer diseases, Rare diseases, Skin diseases categories

Aliases & Classifications for Myxofibrosarcoma

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Myxofibrosarcoma, Aliases & Descriptions:

Name: Myxofibrosarcoma 47
Myxoid Dermatofibrosarcoma Protuberans 60
 
Myxoid Malignant Fibrous Histiocytoma 47
Fibromyxosarcoma 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

47
myxoid malignant fibrous histiocytoma:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Orphanet47 79105
ICD10 via Orphanet26 C49

Summaries for Myxofibrosarcoma

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Wikipedia:63 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

MalaCards based summary: Myxofibrosarcoma, also known as myxoid dermatofibrosarcoma protuberans, is related to fibrous histiocytoma and myxoid liposarcoma. An important gene associated with Myxofibrosarcoma is CREB3L2 (cAMP responsive element binding protein 3-like 2), and among its related pathways are PI3K-Akt signaling pathway and Glioma. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related mouse phenotypes are cellular and hematopoietic system.

Related Diseases for Myxofibrosarcoma

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Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma30.8FUS
2myxoid liposarcoma30.8CREB3L2
3liposarcoma30.8FUS, DES
4dermatofibrosarcoma protuberans30.5DES, S100B
5fibrosarcoma30.1CREB3L2, THBS1, DES
6sarcoma29.5S100B, CREB3L2, CREB3L1, CCNA2, FUS, DES
7fibrous meningioma10.5S100B
8syringoma10.5S100B
9glomus tumor10.5DES
10pleomorphic liposarcoma10.4
11papular mucinosis10.4
12retroperitoneal liposarcoma10.4
13peripheral primitive neuroectodermal tumor10.4FUS
14chondrosarcoma, extraskeletal myxoid10.4CREB3L2
15spindle cell sarcoma10.4S100B, DES
16cutaneous fibrous histiocytoma10.3DES, S100B
17granular cell tumor10.3DES, S100B
18sex cord-gonadal stromal tumor10.3S100B, DES
19hemangiopericytoma10.3S100B, DES
20amelanotic melanoma10.3THBS1, S100B
21malignant mixed mullerian tumor10.3S100B, DES
22myoepithelioma10.3THBS1, S100B
23chordoma10.3S100B, DES
24giant cell tumor10.3S100B, DES
25pleomorphic adenoma10.3S100B, DES
26ganglioneuroma10.3THBS1, S100B
27sarcoma, synovial10.3DES, S100B
28pilocytic astrocytoma10.3S100B, THBS1
29gastrointestinal stromal tumor10.3S100B, DES
30clear cell sarcoma10.3S100B, FUS
31lipoma10.2DES, FUS
32leiomyosarcoma10.2S100B, DES
33uterine fibroid10.2DES, THBS1
34uveal melanoma10.2THBS1, S100B
35abrikosov's tumor10.2GNAS, DES
36neurilemmoma10.2DES, S100B
37smooth muscle tumor10.2S100B, CCNA2, DES
38malignant fibroxanthoma10.2DES, CCNA2, S100B
39burn scar10.1
40burns10.1
41histiocytoma10.1
42ewing sarcoma10.1DES, FUS, S100B
43grade iii astrocytoma10.1CCNA2, THBS1
44leiomyoma10.1S100B, DES
45chondrosarcoma10.1S100B, FUS, DES
46astrocytoma10.1S100B, CCNA2, THBS1
47prostate cancer10.0
48fibroma10.0
49cerebritis10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to myxofibrosarcoma

Symptoms for Myxofibrosarcoma

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Drugs & Therapeutics for Myxofibrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Myxofibrosarcoma

Search NIH Clinical Center for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

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Anatomical Context for Myxofibrosarcoma

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MalaCards organs/tissues related to Myxofibrosarcoma:

31
Heart, Brain, Lung, Breast, Skin, Bone, Skeletal muscle, Thyroid, Prostate

Animal Models for Myxofibrosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Myxofibrosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.9CREB3L1, CCNA2, GNAS, FUS, THBS1
2MP:00053977.8THBS1, FUS, GNAS, CCNA2, CREB3L1
3MP:00053877.3THBS1, FUS, GNAS, CCNA2, CD209
4MP:00107686.9CD209, CREB3L2, CCNA2, GNAS, FUS, THBS1

Publications for Myxofibrosarcoma

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Articles related to Myxofibrosarcoma:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
2
Myxofibrosarcoma directly invading superior vena cava causing obstruction successfully relieved by endovascular stent. (25365347)
2014
3
Increased CD44s and decreased CD44v6 RNA expression are associated with better survival in myxofibrosarcoma patients: a pilot study. (24491153)
2014
4
Myxofibrosarcoma arising in a burn scar. (24354641)
2014
5
An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. (25172220)
2014
6
Very rare case of large obstructive myxofibrosarcoma of the right ventricle assessed with multi-diagnostic imaging techniques. (24694488)
2014
7
Myxofibrosarcoma with associated Mycobacterium infection. (24966999)
2014
8
Appearance of recurrent cardiac myxofibrosarcoma on FDG PET/CT. (24662649)
2014
9
Primary intermediate-grade cardiac myxofibrosarcoma with osseous metaplasia: an extremely rare occurrence with a previously unreported feature. (25246023)
2014
10
Myxofibrosarcoma arising from a chronic burn scar. (24506764)
2014
11
CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall. (23600956)
2013
12
An analysis of factors related to recurrence of myxofibrosarcoma. (23969617)
2013
13
Right-sided low grade myxofibrosarcoma of the heart in an adult. (24532624)
2013
14
Primary cardiac myxofibrosarcoma: a case report and review of the literature. (23389377)
2012
15
The cytologic diagnosis of epithelioid myxofibrosarcoma: a case report. (22927294)
2012
16
Recurrent amplification at 7q21.2 Targets CDK6 gene in primary myxofibrosarcomas and identifies CDK6 overexpression as an independent adverse prognosticator. (22476749)
2012
17
Myxofibrosarcoma of the orbit: case report and review of literature. (21464787)
2012
18
High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer. (23195821)
2012
19
Characterization of gene amplification-driven SKP2 overexpression in myxofibrosarcoma: potential implications in tumor progression and therapeutics. (22322669)
2012
20
18F-FDG PET/CT imaging of multiple myxofibrosarcoma in left upper abdomen and chest wall. (23250511)
2012
21
Myxofibrosarcoma of the infratemporal space. (21768709)
2011
22
A mass of myxofibrosarcoma in the lung. (21554234)
2011
23
Epitheloid myxofibrosarcoma of the parotid gland. (22937388)
2011
24
Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. (20878245)
2011
25
Fine-needle aspiration in myxofibrosarcoma: experience of Institut Curie. (19899126)
2010
26
Myxofibrosarcoma mimicking cutaneous myxoma. (19788445)
2010
27
Primary myxofibrosarcoma of the parotid: case report. (20513245)
2010
28
CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma. (20175824)
2010
29
Primary aortic myxofibrosarcoma mimicking thrombus: findings on CT, MRI, and angiography. (19465836)
2009
30
Large obstructive cardiac myxofibrosarcoma is nearly invisible on transthoracic echocardiogram. (19490014)
2009
31
High-grade infiltrative myxofibrosarcoma in the forearm presenting as acute carpal tunnel syndrome. (18294554)
2008
32
Myxofibrosarcoma of the orbit: an underrecognized entity? Case report and review of the literature. (18096231)
2008
33
Myxofibrosarcoma in the skin. (18494817)
2008
34
Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding. (18701294)
2008
35
Pleomorphic hyalinizing angiectatic tumor with a sarcomatous component recurring as high-grade myxofibrosarcoma. (17493176)
2007
36
Myxofibrosarcoma of the neck. (17038234)
2006
37
Primary cutaneous myxofibrosarcoma mimicking pleomorphic hyalinizing angiectatic tumor (PHAT): a potential diagnostic pitfall. (16121054)
2005
38
Establishment and characterization of a novel myxofibrosarcoma cell line. (16080955)
2005
39
Myxofibrosarcoma of the breast as an unusual variant of malignant fibrous histiocytoma: report of a case. (15338347)
2004
40
Minichromosome maintenance protein in myxofibrosarcoma. (14685255)
2004
41
Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implications. (14608538)
2003
42
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. (11213831)
2001
43
Translocation (2;15)(p23;q21.2) and interstitial deletion of 7q in a case of low-grade myxofibrosarcoma. (11425453)
2001
44
Myxofibrosarcoma of soft tissues: cytomorphologic analysis of a series. (9884819)
1999
45
Cervical myxofibrosarcoma in a renal allograft recipient treated with murine anti-CD3 monoclonal antibody therapy. (9681773)
1998
46
Low-grade myxofibrosarcoma: progression in recurrence. (9088034)
1997
47
Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. (8604805)
1996
48
Myxofibrosarcoma: a correlative cytologic and histologic study of 13 cases examined by fine needle aspiration cytology. (6154396)
1980
49
Myxofibrosarcoma. A study of 30 cases. (15396)
1977
50
Myxofibrosarcoma: a pathologico-anatomical, microangiographic and angiographic correlative study of eight cases. (588917)
1977

Variations for Myxofibrosarcoma

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Expression for genes affiliated with Myxofibrosarcoma

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Search GEO for disease gene expression data for Myxofibrosarcoma.

Pathways for genes affiliated with Myxofibrosarcoma

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Pathways related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3THBS1, CREB3L1, CREB3L2
2
Show member pathways
Signaling Pathways in Glioblastoma36
9.3THBS1, CREB3L1, CREB3L2
3
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
9.3GNAS, CREB3L1, CREB3L2
4
Show member pathways
9.3GNAS, CREB3L1, CREB3L2
5
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
6
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
79.3CREB3L2, CREB3L1, GNAS
8
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
99.3CREB3L2, CREB3L1, GNAS
10
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
119.1CCNA2, GNAS
129.0CREB3L2, CREB3L1, CCNA2
13
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5GNAS, CCNA2, CREB3L1, CREB3L2

Compounds for genes affiliated with Myxofibrosarcoma

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Compounds related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1orcein4310.0S100B, DES
2s 1004310.0DES, S100B
3reticulin4310.0S100B, DES
4mucicarmine4310.0DES, S100B
5b 7234310.0S100B, DES
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.9DES, S100B
7ccl443 2810.7S100B, DES
8hematoxylin439.6S100B, DES
9monensin439.5CCNA2, THBS1
10methionine439.5S100B, THBS1, DES
11hydroxyapatite439.4S100B, THBS1
12norepinephrine43 24 1211.4DES, GNAS, S100B
13bromodeoxyuridine439.2S100B, CCNA2, DES
14polysaccharide439.2THBS1, GNAS, CD209
15gtp43 2810.2THBS1, GNAS, S100B
16gold439.1DES, THBS1, CCNA2
17ethanol43 49 24 1212.1S100B, CCNA2, DES
1812-o-tetradecanoylphorbol 13-acetate439.1CCNA2, THBS1, DES
19heparin43 28 24 1212.1S100B, THBS1, DES
20glycogen43 2410.0DES, CCNA2, S100B
21paclitaxel43 49 1211.0THBS1, CCNA2, S100B
22doxorubicin43 49 1211.0CCNA2, THBS1, DES
23proline439.0DES, CCNA2, S100B
24estradiol43 24 1211.0CCNA2, THBS1, DES
25forskolin43 49 1210.9GNAS, CCNA2, S100B
26cysteine438.9S100B, GNAS, THBS1, DES
27cyclosporin a43 28 5910.8S100B, CCNA2, THBS1
28leucine438.8FUS, GNAS, S100B
29dopamine43 28 24 1211.7GNAS, CCNA2, S100B
30paraffin438.7S100B, CCNA2, THBS1, DES
31adenylate438.7DES, GNAS, CCNA2, S100B
32testosterone43 59 24 1211.7DES, THBS1, CCNA2, S100B
33steroid438.7S100B, CCNA2, GNAS, DES
34vegf438.6S100B, CCNA2, THBS1, DES
35arginine438.6DES, GNAS, CCNA2, S100B
36estrogen438.6S100B, CCNA2, THBS1, DES
37retinoic acid43 249.6DES, THBS1, CCNA2, S100B
38alanine438.5THBS1, GNAS, CCNA2, S100B
39dexamethasone43 49 28 1211.4THBS1, CCNA2, S100B, CD209
40thymidine43 249.2DES, THBS1, GNAS, CCNA2, S100B
41progesterone43 28 59 24 1212.2DES, THBS1, GNAS, CCNA2, S100B
42nitric oxide43 24 1210.2S100B, CCNA2, GNAS, THBS1, DES
43threonine438.2DES, THBS1, GNAS, CCNA2, S100B
44oxygen43 249.2DES, THBS1, GNAS, CCNA2, S100B
45glucose438.2DES, THBS1, GNAS, CCNA2, S100B
46serine438.1DES, THBS1, GNAS, CCNA2, S100B
47cyclic amp43 249.1S100B, CREB3L2, CREB3L1, CCNA2, GNAS, DES
48lipid438.0THBS1, GNAS, CCNA2, S100B, CD209
49tyrosine437.6DES, THBS1, GNAS, CCNA2, S100B, CD209
50calcium43 49 24 1210.5DES, THBS1, GNAS, CCNA2, S100B, CD209

GO Terms for genes affiliated with Myxofibrosarcoma

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Biological processes related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cartilage developmentGO:00512169.6CREB3L2, GNAS
2response to endoplasmic reticulum stressGO:00349769.3CREB3L2, THBS1
3response to unfolded proteinGO:00069869.2CREB3L2, CREB3L1, THBS1

Molecular functions related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428028.7S100B, FUS, THBS1, DES

Products for genes affiliated with Myxofibrosarcoma

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Sources for Myxofibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet