MCID: MYX013
MIFTS: 43

Myxofibrosarcoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Myxofibrosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A sarcoma (from the Greek σάρξ sarx meaning \"flesh\") is a cancer that arises from transformed... more...

MalaCards: Myxofibrosarcoma, also known as myxoid dermatofibrosarcoma protuberans, is related to sarcoma and liposarcoma. An important gene associated with Myxofibrosarcoma is FUS (fused in sarcoma), and among its related pathways are Signaling by VEGF and Vasopressin-regulated water reabsorption. The compounds cycloheximide and orcein have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and lung, and related mouse phenotypes are embryogenesis and homeostasis/metabolism.

Aliases & Classifications for Myxofibrosarcoma

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48Orphanet, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
myxoid malignant fibrous histiocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

myxofibrosarcoma 48
myxoid dermatofibrosarcoma protuberans 60
myxoid malignant fibrous histiocytoma 48
fibromyxosarcoma 48


External Ids:

ICD10 via Orphanet26 C49

Related Diseases for Myxofibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.3S100B, CREB3L1, CREB3L2, MET, FLT1, DES
2liposarcoma30.2VIM, DES, FUS
3fibrous histiocytoma30.1FUS
4myxoid liposarcoma30.1CREB3L2
5cutaneous fibrous histiocytoma29.9S100B, DES
6fibrosarcoma29.9VIM, CREB3L2, DES, CD36, THBS1
7prostate cancer29.8CDK6, FLT1, MET, GNAS, CCNA2, CDK1
8pleomorphic liposarcoma10.3
9histiocytoma10.1
10multiple myeloma10.0CKS1B
11acute leukemia10.0CCNA2
12syringoma10.0S100B
13glomerulonephritis10.0MME
14benign meningioma10.0CCNA2
15schizophrenia10.0S100B
16peripheral primitive neuroectodermal tumor10.0FUS
17fibrous meningioma10.0S100B
18hepatitis c10.0CD209
19infantile myofibromatosis10.0DES
20myocardial infarction10.0MME
21lymphangioleiomyomatosis10.0DES
22medulloblastoma10.0DES, S100B
23pulmonary fibrosis10.0CD36
24extraskeletal myxoid chondrosarcoma10.0CREB3L2
25bladder carcinoma10.0CCNA2, THBS1
26hypertension10.0MME
27myeloid leukemia10.0CCNA2, CDK1
28uterine sarcoma10.0MME, DES
29retinopathy of prematurity10.0FLT1
30cystadenoma10.0MME
31laryngeal squamous cell carcinoma10.0SKP2, CCNA2
32pituitary adenoma10.0GNAS
33perineurioma10.0VIM, S100B
34hemangioma10.0THBS1, KDR
35angiomyolipoma10.0VIM, DES
36age related macular degeneration10.0FLT1
37arthritis10.0THBS1, FLT1
38herpes simplex10.0THBS1
39lipoma10.0FUS, DES
40glomus tumor10.0DES, VIM
41epithelioid leiomyosarcoma10.0DES, VIM
42proteinuria10.0FLT1, KDR
43mesenchymal chondrosarcoma10.0DES, VIM
44leydig cell tumor10.0GNAS
45oral cancer10.0SKP2, CDK1, CCNA2
46pheochromocytoma10.0CCNA2, GNAS
47pseudosarcomatous fibromatosis10.0VIM, DES
48malaria10.0KDR, CD36
49spindle cell carcinoma10.0DES, VIM
50intracranial hemorrhage in brain cerebrovascular malformations10.0FLT1, KDR

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to myxofibrosarcoma

Clinical Features for Myxofibrosarcoma

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Drugs & Therapeutics for Myxofibrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Myxofibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Myxofibrosarcoma

Search NIH Clinical Center for Myxofibrosarcoma

Search CenterWatch for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

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Anatomical Context for Myxofibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Myxofibrosarcoma:

32
Bone, Colon, Lung, Breast

Animal Models for Myxofibrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxofibrosarcoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.0CCNA2, VIM
2MP:00053768.8CD36, CDK1, CD209, DES, GNAS
3MP:00053798.5CDK1, CDK6, SKP2, FUS
4MP:00053698.3MET, CDK6, KDR, CD36, THBS1, FLT1
5MP:00053898.2FLT1, CDK1, CKS1B, THBS1, FUS, SKP2
6MP:00053867.7FUS, KDR, DES, VIM, S100B, GNAS
7MP:00053857.3DES, VIM, GNAS, MET, FLT1, KDR
8MP:00053707.0CDK1, THBS1, KDR, SKP2, MME, CD36
9MP:00053976.4KDR, SKP2, MCM7, CD36, CDK6, FLT1
10MP:00053876.0CD36, VIM, CKS1B, CCNA2, GNAS, MET
11MP:00053785.8CDK6, MCM7, FUS, THBS1, KDR, SKP2
12MP:00053845.2CKS1B, VIM, CDK6, CCNA2, GNAS, CREB3L1
13MP:00107685.1CDK1, CD36, GNAS, DES, FLT1, MET

Publications for Myxofibrosarcoma

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Genetic Variations for Myxofibrosarcoma

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Expression for genes affiliated with Myxofibrosarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxofibrosarcoma

Search GEO for disease gene expression data for Myxofibrosarcoma.

Pathways for genes affiliated with Myxofibrosarcoma

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9FLT1, KDR
29.7CREB3L2, GNAS, CREB3L1
39.7FLT1, KDR, CCNA2
4
Hide members
9.6CCNA2, CDK1
5
Hide members
9.6CCNA2, CDK1
69.6MET, KDR, FLT1
79.6THBS1, MET, CD36
89.5MET, SKP2, CCNA2
9
Hide members
9.5CKS1B, MCM7
10
Development Endothelin-1/EDNRA signaling
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9.5CREB3L2, CREB3L1, KDR, GNAS
119.1MCM7, CCNA2, CDK1
12
Hide members
9.1CCNA2, KDR, FLT1, VIM, MET
139.0CDK1, SKP2, CKS1B
148.9VIM, CCNA2, CDK1, SKP2
15
Hide members
8.8THBS1, CDK1, CDK6
168.8SKP2, CDK6, CKS1B
178.8CDK1, SKP2, CCNA2, CKS1B
188.8CDK6, MET, THBS1, VIM
19
Hide members
8.7THBS1, CREB3L2, CREB3L1, MET, CDK6
20
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8.7CREB3L1, CCNA2, CREB3L2, GNAS, CDK6
21
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8.6CCNA2, CDK6, SKP2, CKS1B
22
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8.5KDR, THBS1, CDK6, FLT1, MET
23
Hide members
8.5CCNA2, MCM7, CDK6, SKP2
248.1KDR, CDK6, THBS1, MET, CREB3L2, CREB3L1
258.0CCNA2, SKP2, CDK6, CREB3L2, CREB3L1, CDK1
26
Cell cycle Cell cycle (generic schema)
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7.9CKS1B, SKP2, CCNA2, CDK6, CDK1
27
Hide members
7.9SKP2, CCNA2, MCM7, CDK1, CDK6
28
Hide members
7.6MCM7, SKP2, CDK1, CCNA2, CKS1B, VIM
29
Hide members
7.2CREB3L1, CDK6, MCM7, SKP2, CDK1, CCNA2

Compounds for genes affiliated with Myxofibrosarcoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5MME
2orcein4410.1S100B, VIM, DES
3s 1004410.0VIM, DES, S100B
4dexamethasone44 49 28 1112.7MME, CCNA2, CD209, S100B, KDR
5glucose449.7THBS1, FLT1, MET
6bromodeoxyuridine449.5CCNA2, MME, DES, S100B, VIM
7hematoxylin449.5S100B, DES, VIM, FLT1
8amsacrine44 1110.3CDK1, CCNA2, VIM
9paclitaxel44 49 1111.3THBS1, KDR, S100B, CDK1, CCNA2
10heparan sulfate44 2410.3THBS1, KDR, DES, MET, VIM
11heparin44 28 11 2412.2FLT1, DES, CDK1, S100B, CD36
12p002449.2MET, FLT1, SKP2, DES, GNAS
13hydroxyapatite449.1CD36, VIM, S100B, THBS1
14cytarabine44 49 1111.1VIM, CCNA2, CDK1, CD36, MME
15methionine448.9S100B, DES, VIM, CDK1, THBS1, MME
16monensin448.9CCNA2, CDK1, CDK6, THBS1
17dmso448.9CCNA2, CDK1, CD36, THBS1, VIM
18matrigel448.9THBS1, VIM, MET, FLT1, CD36, MME
19adriamycin448.8VIM, MET, MME, CD36, DES, CDK1
20sb 20358044 599.8CDK1, VIM, CD36, THBS1, CCNA2, FLT1
21serine448.7S100B, FLT1, GNAS, THBS1, CDK1, DES
22roscovitine448.7CDK1, CDK6, CCNA2, VIM
23glycogen44 249.7S100B, CDK1, DES, CCNA2, MET, VIM
24wortmannin448.7MET, CDK1, KDR, S100B, VIM, THBS1
2512-o-tetradecanoylphorbol 13-acetate448.7VIM, CCNA2, MET, THBS1, DES, CDK1
26arginine448.6VIM, CCNA2, GNAS, MET, DES, MME
27adenylate448.6MME, CDK1, DES, VIM, CCNA2, S100B
28cyclic amp44 249.5CDK1, CREB3L2, VIM, CCNA2, S100B, GNAS
29nitric oxide44 11 2410.4MME, CCNA2, S100B, GNAS, MET, FLT1
30tgf beta1448.4FLT1, CCNA2, THBS1, KDR, CD36, CDK6
31testosterone44 59 11 2411.4MET, S100B, CDK1, MME, THBS1, CCNA2
32rottlerin448.4CDK6, CDK1, CCNA2, CD36
33cysteine448.3THBS1, KDR, DES, MET, GNAS, S100B
34genistein44 28 59 2 11 2413.3CD36, CDK1, FLT1, KDR, MET, CCNA2
35h2o2448.2VIM, CDK1, THBS1, CD36, DES, MME
36doxorubicin44 49 1110.1MME, KDR, CDK1, DES, FLT1, MET
37proline448.1CDK1, S100B, VIM, MET, DES, CDK6
38lipid447.8CDK1, FLT1, MET, GNAS, CCNA2, VIM
39threonine447.7GNAS, MET, S100B, CCNA2, CDK6, DES
40ly294002447.6SKP2, CCNA2, CDK6, CD36, MET, KDR
41alanine447.6CDK1, CDK6, CCNA2, S100B, GNAS, MET
42vegf447.6S100B, THBS1, MME, CD36, CDK1, DES
43progesterone44 59 28 11 2411.4VIM, S100B, GNAS, MET, FLT1, DES
44rapamycin447.4SKP2, KDR, CDK1, MET, VIM, CDK6
45oxygen44 248.3CCNA2, FLT1, DES, CDK6, CDK1, MME
46paraffin447.2CD36, THBS1, KDR, SKP2, MME, CDK1
47thymidine44 248.1S100B, GNAS, MET, FLT1, DES, CDK6
48calcium44 49 11 249.7FLT1, CD36, CDK1, DES, MME, THBS1
49retinoic acid44 247.7CDK6, VIM, CCNA2, S100B, MET, DES
50tyrosine445.9CDK6, DES, CKS1B, CCNA2, S100B, KDR

GO Terms for genes affiliated with Myxofibrosarcoma

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16Gene Ontology
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Cellular components related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ruffleGO:0017268.8CDK6, GNAS, S100B
2nucleoplasmGO:0056548.1FUS, SKP2, MCM7, CDK1, CCNA2, CKS1B

Biological processes related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:0301949.9CD36, THBS1
2G1/S transition of mitotic cell cycleGO:0000829.8SKP2, MCM7
3positive regulation of MAPK cascadeGO:0434109.8KDR, CD36, FLT1
4mitotic G2 DNA damage checkpointGO:0070959.7CCNA2, CDK1
5positive regulation of angiogenesisGO:0457669.6FLT1, KDR, THBS1
6astrocyte developmentGO:0140029.4CDK6, VIM
7activation of MAPK activityGO:0001879.3THBS1, CDK1, MET
8cell proliferationGO:0082838.7CKS1B, S100B, MET, MCM7, SKP2
9response to drugGO:0424938.4THBS1, MCM7, CDK1, GNAS
10mitotic cell cycleGO:0002787.6CKS1B, CCNA2, CDK6, CDK1, MCM7, SKP2

Molecular functions related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:0504319.9THBS1, CD36
2vascular endothelial growth factor-activated receptor activityGO:0050219.6KDR, FLT1
3identical protein bindingGO:0428028.5S100B, DES, SKP2, THBS1, FUS, VIM
4protein bindingGO:0055154.7GNAS, VIM, CKS1B, CCNA2, S100B, MET

Products for genes affiliated with Myxofibrosarcoma

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  • Antibodies
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Sources for Myxofibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet