MCID: MYX013
MIFTS: 45

Myxofibrosarcoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Myxofibrosarcoma

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Wikipedia:65 A sarcoma (from the Greek ???? sarx meaning \"flesh\") is a cancer that arises from transformed cells of... more...

MalaCards based summary: Myxofibrosarcoma, also known as myxoid malignant fibrous histiocytoma, is related to fibrous histiocytoma and myxoid liposarcoma. An important gene associated with Myxofibrosarcoma is CREB3L2 (cAMP responsive element binding protein 3-like 2), and among its related pathways are PI3K-Akt signaling pathway and Glioma. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Myxofibrosarcoma

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet
See all sources

Myxofibrosarcoma, Aliases & Descriptions:

Name: Myxofibrosarcoma 48 62
Myxoid Malignant Fibrous Histiocytoma 48 62
 
Fibromyxosarcoma 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
myxoid malignant fibrous histiocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


External Ids:

ICD10 via Orphanet26 C49

Related Diseases for Myxofibrosarcoma

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Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma30.8FUS
2myxoid liposarcoma30.8CREB3L2
3liposarcoma30.8FUS, DES
4dermatofibrosarcoma protuberans30.5DES, S100B
5fibrosarcoma30.1CREB3L2, THBS1, DES
6sarcoma29.5S100B, CREB3L2, CREB3L1, CCNA2, FUS, DES
7fibrous meningioma10.5S100B
8syringoma10.5S100B
9paraganglioma10.5DES
10peripheral primitive neuroectodermal tumor10.4FUS
11pleomorphic liposarcoma10.4
12papular mucinosis10.4
13retroperitoneal liposarcoma10.4
14extraskeletal myxoid chondrosarcoma10.4CREB3L2
15spindle cell sarcoma10.4S100B, DES
16cutaneous fibrous histiocytoma10.4DES, S100B
17granular cell tumor10.3DES, S100B
18sex cord-gonadal stromal tumor10.3S100B, DES
19hemangiopericytoma10.3S100B, DES
20amelanotic melanoma10.3THBS1, S100B
21malignant mixed mullerian tumor10.3S100B, DES
22myoepithelioma10.3THBS1, S100B
23chordoma10.3S100B, DES
24giant cell tumor10.3S100B, DES
25pleomorphic adenoma10.3S100B, DES
26ganglioneuroma10.3THBS1, S100B
27synovial sarcoma10.3DES, S100B
28pilocytic astrocytoma10.3S100B, THBS1
29gastrointestinal stromal tumor10.3S100B, DES
30clear cell sarcoma10.3S100B, FUS
31lipoma10.2DES, FUS
32leiomyosarcoma10.2S100B, DES
33uterine fibroid10.2DES, THBS1
34uveal melanoma10.2THBS1, S100B
35abrikosov's tumor10.2GNAS, DES
36neurilemmoma10.2DES, S100B
37smooth muscle tumor10.2S100B, CCNA2, DES
38malignant fibroxanthoma10.2DES, CCNA2, S100B
39burn scar10.1
40burns10.1
41histiocytoma10.1
42grade iii astrocytoma10.1CCNA2, THBS1
43leiomyoma10.1S100B, DES
44chondrosarcoma10.1S100B, FUS, DES
45astrocytoma10.1S100B, CCNA2, THBS1
46prostate cancer10.0
47fibroma10.0
48carpal tunnel syndrome10.0
49cerebritis10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to myxofibrosarcoma

Symptoms for Myxofibrosarcoma

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Drugs & Therapeutics for Myxofibrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Myxofibrosarcoma

Search NIH Clinical Center for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

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Anatomical Context for Myxofibrosarcoma

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MalaCards organs/tissues related to Myxofibrosarcoma:

32
Lung, Breast, Bone, Colon, Brain, Skin, Heart, Skeletal muscle, Thyroid, Prostate

Animal Models for Myxofibrosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Myxofibrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.9CREB3L1, CCNA2, GNAS, FUS, THBS1
2MP:00053977.8THBS1, FUS, GNAS, CCNA2, CREB3L1
3MP:00053877.3THBS1, FUS, GNAS, CCNA2, CD209
4MP:00107686.9CD209, CREB3L2, CCNA2, GNAS, FUS, THBS1

Publications for Myxofibrosarcoma

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Articles related to Myxofibrosarcoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
2
Myxofibrosarcoma directly invading superior vena cava causing obstruction successfully relieved by endovascular stent. (25365347)
2014
3
Increased CD44s and decreased CD44v6 RNA expression are associated with better survival in myxofibrosarcoma patients: a pilot study. (24491153)
2014
4
Myxofibrosarcoma arising in a burn scar. (24354641)
2014
5
An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. (25172220)
2014
6
Very rare case of large obstructive myxofibrosarcoma of the right ventricle assessed with multi-diagnostic imaging techniques. (24694488)
2014
7
Myxofibrosarcoma with associated Mycobacterium infection. (24966999)
2014
8
Appearance of recurrent cardiac myxofibrosarcoma on FDG PET/CT. (24662649)
2014
9
Primary intermediate-grade cardiac myxofibrosarcoma with osseous metaplasia: an extremely rare occurrence with a previously unreported feature. (25246023)
2014
10
Myxofibrosarcoma arising from a chronic burn scar. (24506764)
2014
11
CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall. (23600956)
2013
12
An analysis of factors related to recurrence of myxofibrosarcoma. (23969617)
2013
13
Primary cardiac myxofibrosarcoma: a case report and review of the literature. (23389377)
2012
14
The cytologic diagnosis of epithelioid myxofibrosarcoma: a case report. (22927294)
2012
15
Recurrent amplification at 7q21.2 Targets CDK6 gene in primary myxofibrosarcomas and identifies CDK6 overexpression as an independent adverse prognosticator. (22476749)
2012
16
Myxofibrosarcoma of the orbit: case report and review of literature. (21464787)
2012
17
High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer. (23195821)
2012
18
Characterization of gene amplification-driven SKP2 overexpression in myxofibrosarcoma: potential implications in tumor progression and therapeutics. (22322669)
2012
19
18F-FDG PET/CT imaging of multiple myxofibrosarcoma in left upper abdomen and chest wall. (23250511)
2012
20
Pleomorphic hyalinizing angiectatic tumor: a report of 3 new cases, 1 with sarcomatous myxofibrosarcoma component and another with unreported soft tissue palpebral location. (22024990)
2012
21
Myxofibrosarcoma of the infratemporal space. (21768709)
2011
22
A mass of myxofibrosarcoma in the lung. (21554234)
2011
23
Epitheloid myxofibrosarcoma of the parotid gland. (22937388)
2011
24
Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. (20878245)
2011
25
Fine-needle aspiration in myxofibrosarcoma: experience of Institut Curie. (19899126)
2010
26
Myxofibrosarcoma mimicking cutaneous myxoma. (19788445)
2010
27
Primary myxofibrosarcoma of the parotid: case report. (20513245)
2010
28
CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma. (20175824)
2010
29
Primary aortic myxofibrosarcoma mimicking thrombus: findings on CT, MRI, and angiography. (19465836)
2009
30
Large obstructive cardiac myxofibrosarcoma is nearly invisible on transthoracic echocardiogram. (19490014)
2009
31
High-grade infiltrative myxofibrosarcoma in the forearm presenting as acute carpal tunnel syndrome. (18294554)
2008
32
Myxofibrosarcoma of the orbit: an underrecognized entity? Case report and review of the literature. (18096231)
2008
33
Myxofibrosarcoma in the skin. (18494817)
2008
34
Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding. (18701294)
2008
35
Pleomorphic hyalinizing angiectatic tumor with a sarcomatous component recurring as high-grade myxofibrosarcoma. (17493176)
2007
36
Myxofibrosarcoma of the neck. (17038234)
2006
37
Primary cutaneous myxofibrosarcoma mimicking pleomorphic hyalinizing angiectatic tumor (PHAT): a potential diagnostic pitfall. (16121054)
2005
38
Establishment and characterization of a novel myxofibrosarcoma cell line. (16080955)
2005
39
Myxofibrosarcoma of the breast as an unusual variant of malignant fibrous histiocytoma: report of a case. (15338347)
2004
40
Minichromosome maintenance protein in myxofibrosarcoma. (14685255)
2004
41
Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implications. (14608538)
2003
42
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. (11213831)
2001
43
Translocation (2;15)(p23;q21.2) and interstitial deletion of 7q in a case of low-grade myxofibrosarcoma. (11425453)
2001
44
Myxofibrosarcoma of soft tissues: cytomorphologic analysis of a series. (9884819)
1999
45
Cervical myxofibrosarcoma in a renal allograft recipient treated with murine anti-CD3 monoclonal antibody therapy. (9681773)
1998
46
Low-grade myxofibrosarcoma: progression in recurrence. (9088034)
1997
47
Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. (8604805)
1996
48
Myxofibrosarcoma: a correlative cytologic and histologic study of 13 cases examined by fine needle aspiration cytology. (6154396)
1980
49
Myxofibrosarcoma. A study of 30 cases. (15396)
1977
50
Myxofibrosarcoma: a pathologico-anatomical, microangiographic and angiographic correlative study of eight cases. (588917)
1977

Variations for Myxofibrosarcoma

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Expression for genes affiliated with Myxofibrosarcoma

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Expression patterns in normal tissues for genes affiliated with Myxofibrosarcoma

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Pathways for genes affiliated with Myxofibrosarcoma

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Pathways related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3THBS1, CREB3L1, CREB3L2
2
Show member pathways
Signaling Pathways in Glioblastoma37
9.3THBS1, CREB3L1, CREB3L2
3
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.3GNAS, CREB3L1, CREB3L2
4
Show member pathways
9.3GNAS, CREB3L1, CREB3L2
5
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
6
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
79.3CREB3L2, CREB3L1, GNAS
8
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
99.3CREB3L2, CREB3L1, GNAS
10
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
119.1CCNA2, GNAS
129.0CREB3L2, CREB3L1, CCNA2
13
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5GNAS, CCNA2, CREB3L1, CREB3L2

Compounds for genes affiliated with Myxofibrosarcoma

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Compounds related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1orcein4410.0S100B, DES
2s 1004410.0DES, S100B
3reticulin4410.0S100B, DES
4mucicarmine4410.0DES, S100B
5b 7234410.0S100B, DES
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9DES, S100B
7ccl444 2810.7S100B, DES
8hematoxylin449.6S100B, DES
9monensin449.5CCNA2, THBS1
10methionine449.5S100B, THBS1, DES
11hydroxyapatite449.4S100B, THBS1
12norepinephrine44 24 1111.4DES, GNAS, S100B
13bromodeoxyuridine449.2S100B, CCNA2, DES
14polysaccharide449.2THBS1, GNAS, CD209
15gtp44 2810.2THBS1, GNAS, S100B
16gold449.1DES, THBS1, CCNA2
17ethanol44 50 24 1112.1S100B, CCNA2, DES
1812-o-tetradecanoylphorbol 13-acetate449.1CCNA2, THBS1, DES
19heparin44 28 24 1112.1S100B, THBS1, DES
20glycogen44 2410.0DES, CCNA2, S100B
21paclitaxel44 50 1111.0THBS1, CCNA2, S100B
22doxorubicin44 50 1111.0CCNA2, THBS1, DES
23proline449.0DES, CCNA2, S100B
24estradiol44 24 1111.0CCNA2, THBS1, DES
25forskolin44 50 1110.9GNAS, CCNA2, S100B
26cysteine448.9S100B, GNAS, THBS1, DES
27cyclosporin a44 28 6110.8S100B, CCNA2, THBS1
28leucine448.8FUS, GNAS, S100B
29dopamine44 28 24 1111.7GNAS, CCNA2, S100B
30paraffin448.7S100B, CCNA2, THBS1, DES
31adenylate448.7DES, GNAS, CCNA2, S100B
32testosterone44 61 24 1111.7DES, THBS1, CCNA2, S100B
33steroid448.7S100B, CCNA2, GNAS, DES
34vegf448.6S100B, CCNA2, THBS1, DES
35arginine448.6DES, GNAS, CCNA2, S100B
36estrogen448.6S100B, CCNA2, THBS1, DES
37retinoic acid44 249.6DES, THBS1, CCNA2, S100B
38alanine448.5THBS1, GNAS, CCNA2, S100B
39dexamethasone44 50 28 1111.4THBS1, CCNA2, S100B, CD209
40thymidine44 249.2DES, THBS1, GNAS, CCNA2, S100B
41progesterone44 28 61 24 1112.2DES, THBS1, GNAS, CCNA2, S100B
42nitric oxide44 24 1110.2S100B, CCNA2, GNAS, THBS1, DES
43threonine448.2DES, THBS1, GNAS, CCNA2, S100B
44oxygen44 249.2DES, THBS1, GNAS, CCNA2, S100B
45glucose448.2DES, THBS1, GNAS, CCNA2, S100B
46serine448.1DES, THBS1, GNAS, CCNA2, S100B
47cyclic amp44 249.1S100B, CREB3L2, CREB3L1, CCNA2, GNAS, DES
48lipid448.0THBS1, GNAS, CCNA2, S100B, CD209
49tyrosine447.6DES, THBS1, GNAS, CCNA2, S100B, CD209
50calcium44 50 24 1110.5DES, THBS1, GNAS, CCNA2, S100B, CD209

GO Terms for genes affiliated with Myxofibrosarcoma

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Biological processes related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cartilage developmentGO:0512169.6CREB3L2, GNAS
2response to endoplasmic reticulum stressGO:0349769.3CREB3L2, THBS1
3response to unfolded proteinGO:0069869.2CREB3L2, CREB3L1, THBS1

Molecular functions related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.7S100B, FUS, THBS1, DES

Products for genes affiliated with Myxofibrosarcoma

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Sources for Myxofibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet