MCID: MYX013
MIFTS: 35

Myxofibrosarcoma malady

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Myxofibrosarcoma

Aliases & Descriptions for Myxofibrosarcoma:

Name: Myxofibrosarcoma 56
Fibromyxosarcoma 56 69
Dermatofibrosarcoma Protuberans, Myxoid 69
Myxoid Malignant Fibrous Histiocytoma 56

Characteristics:

Orphanet epidemiological data:

56
myxofibrosarcoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA79105
ICD10 via Orphanet 34 C49.9

Summaries for Myxofibrosarcoma

MalaCards based summary : Myxofibrosarcoma, also known as fibromyxosarcoma, is related to intrahepatic bile duct cystadenoma and myoma. An important gene associated with Myxofibrosarcoma is CREB3L1 (CAMP Responsive Element Binding Protein 3 Like 1), and among its related pathways/superpathways are Viral carcinogenesis and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and breast.

Wikipedia : 71 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

Related Diseases for Myxofibrosarcoma

Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 intrahepatic bile duct cystadenoma 10.2 DES S100B
2 myoma 10.2 DES S100B
3 spleen angiosarcoma 10.2 DES S100B
4 ovarian cystadenoma 10.2 DES S100B
5 biliary papillomatosis 10.2 DES S100B
6 cavernous sinus meningioma 10.2 DES S100B
7 bone deterioration disease 10.2 DES S100B
8 vulvar squamous papilloma 10.2 DES S100B
9 mediastinum liposarcoma 10.2 DES S100B
10 dyslexia 10.2 DES S100B
11 skin glomus tumor 10.2 DES S100B
12 pustulosis palmaris et plantaris 10.2 DES MKI67
13 diarrhea, chronic, with villous atrophy 10.2 DES S100B
14 rectal neoplasm 10.2 DES MKI67
15 uterine hypoplasia 10.2 CCNA2 MKI67
16 popliteal pterygium syndrome, bartsocas-papas type 10.2 MKI67 S100B
17 his bundle tachycardia 10.2 MKI67 S100B
18 sengers syndrome 10.2 DES S100B
19 c-p angle neurinoma 10.1 DES S100B
20 onychocytic matricoma 10.1 CD36 S100B
21 diabetes persistent mullerian ducts 10.1 DES S100B
22 enchondromatosis dwarfism deafness 10.1 DES MKI67 S100B
23 cecum adenoma 10.1 DES MKI67 S100B
24 sarcoma 10.1
25 gastrointestinal stromal tumor 10.1 DES MKI67 S100B
26 mediastinum sarcoma 10.0 CREB3L2 DES
27 epimetaphyseal dysplasia cataract 10.0 MKI67 S100B
28 congenital muscular dystrophy with hyperlaxity 10.0 DES FUS
29 coronary restenosis 10.0 FUS S100B
30 functionless pituitary adenoma 10.0 CREB3L2 FUS
31 intracranial liposarcoma 10.0 CREB3L2 FUS
32 neutrophil immunodeficiency syndrome 10.0 DES S100B
33 pinta disease 10.0 CREB3L2 FUS
34 liposarcoma of the ovary 9.9 CREB3L2 FUS
35 liposarcoma 9.9
36 juvenile xanthogranuloma 9.9 DES FUS S100B
37 ehlers-danlos syndrome, cardiac valvular form 9.9 CD36 CREB3L1
38 colorectal cancer 1 9.9 CREB3L2 FUS
39 kala-azar 1 9.9 DES FUS S100B
40 undifferentiated pleomorphic sarcoma 9.9
41 gestational choriocarcinoma 9.8 CREB3L2 FUS
42 myxoid liposarcoma 9.8
43 burn scar 9.8
44 burns 9.8
45 histiocytoma 9.8
46 fibrous histiocytoma 9.8
47 fibromatosis 9.6
48 dermatofibrosarcoma protuberans 9.6
49 dedifferentiated liposarcoma 9.6
50 congestive heart failure 9.6

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to Myxofibrosarcoma

Symptoms & Phenotypes for Myxofibrosarcoma

Drugs & Therapeutics for Myxofibrosarcoma

Drugs for Myxofibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 1 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3,Phase 1 31703
6 Alkylating Agents Phase 2, Phase 3
7 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 1
8 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
9 Isophosphamide mustard Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
11 Antineoplastic Agents, Alkylating Phase 2, Phase 3
12 razoxane Phase 2
13 Protective Agents Phase 2
14 Antimitotic Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
2 Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Recruiting NCT02601209 Phase 1, Phase 2
3 Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting NCT02584309 Phase 2
4 Alisertib in Treating Patients With Advanced or Metastatic Sarcoma Active, not recruiting NCT01653028 Phase 2
5 Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting NCT03009201 Phase 1

Search NIH Clinical Center for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

Anatomical Context for Myxofibrosarcoma

MalaCards organs/tissues related to Myxofibrosarcoma:

39
Heart, Skin, Breast, Lung, Brain, Prostate, Skeletal Muscle

Publications for Myxofibrosarcoma

Articles related to Myxofibrosarcoma:

(show top 50) (show all 171)
id Title Authors Year
1
A histological positive margin after surgery is correlated with high local re-recurrence rate in patients with recurrent myxofibrosarcoma. ( 28064204 )
2017
2
A Case of Myxofibrosarcoma in an Unusual Thoracic Location. ( 26933417 )
2016
3
Tail of Superficial Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma After Preoperative Radiotherapy. ( 27127141 )
2016
4
Massively Distended Abdomen Caused by Fibromatosis Previously Misdiagnosed as Myxofibrosarcoma. ( 27858546 )
2016
5
Myxofibrosarcoma in the Thenar Eminence. ( 27505448 )
2016
6
Modified partial maxillary swing approach for myxofibrosarcoma in pterygopalatine fossa. ( 27501198 )
2016
7
Myxofibrosarcoma. ( 27591498 )
2016
8
Myxofibrosarcoma of the extremity and trunk: a multidisciplinary approach leads to good local rates of LOCAL control. ( 27909132 )
2016
9
An unexpected skin ulcer and soft tissue necrosis after the nonconcurrent combination of proton beam therapy and pazopanib: A case of myxofibrosarcoma. ( 27523716 )
2016
10
Myxofibrosarcoma presenting as an exophytic, multi-lobed nodule on the leg. ( 27617600 )
2016
11
A case report of primary cardiac myxofibrosarcoma presenting with severe congestive heart failure. ( 27387491 )
2016
12
Primary cardiac myxofibrosarcoma in a young woman. ( 27594370 )
2016
13
Giant myxofibrosarcoma of the orbit: a rare case and a review of the literature. ( 27298287 )
2016
14
Myxofibrosarcoma of the heart: A case report with positive pleural effusion cytology. ( 27546198 )
2016
15
Soft tissue myxofibrosarcoma: A clinico-pathological analysis of a series of 75 patients with emphasis on the epithelioid variant. ( 27076198 )
2016
16
Surgical margins do not affect prognosis in high grade myxofibrosarcoma. ( 27260849 )
2016
17
Integrin-I+10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma. ( 27577794 )
2016
18
Optimal Percent Myxoid Component to Predict Outcome in High-Grade Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma. ( 26759307 )
2016
19
Myxofibrosarcoma - Case report. ( 26982788 )
2016
20
Right cardiac intracavitary metastases from a primary intracranial myxofibrosarcoma. ( 27013654 )
2016
21
Coronary thrombus aspiration revealed tumorous embolism of myxofibrosarcoma from the left atrium. ( 25711731 )
2015
22
Primary renal myxofibrosarcoma. ( 26008776 )
2015
23
Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. ( 25940995 )
2015
24
High-grade myxofibrosarcoma-presented as a large mass of right upper arm. ( 25673608 )
2015
25
Intramuscular high-grade myxofibrosarcoma of left buttock of 66-year-old male patient - approach to systematic histopathological reporting. ( 26743304 )
2015
26
Prognostic impact of CD109 expression in myxofibrosarcoma. ( 26031650 )
2015
27
Low-grade myxofibrosarcoma following a metal implantation in femur: a case report. ( 24444015 )
2014
28
Very rare case of large obstructive myxofibrosarcoma of the right ventricle assessed with multi-diagnostic imaging techniques. ( 24694488 )
2014
29
Clinical aggressiveness of myxofibrosarcomas associates with down-regulation of p12CDK2AP1: prognostic implication of a putative tumor suppressor that induces cell cycle arrest and apoptosis via mitochondrial pathway. ( 24889487 )
2014
30
Paratesticular myxofibrosarcoma. ( 25118763 )
2014
31
MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value. ( 24889995 )
2014
32
Short-term spontaneous regression of myxofibrosarcoma in the scapular region. ( 24910124 )
2014
33
Metachronous Myxofibrosarcoma and Osteosarcoma: Case Report and Review of the Literature. ( 24891554 )
2014
34
Increased CD44s and decreased CD44v6 RNA expression are associated with better survival in myxofibrosarcoma patients: a pilot study. ( 24491153 )
2014
35
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance. ( 25426549 )
2014
36
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. ( 24788530 )
2014
37
High-dose-rate Interstitial Brachytherapy Boost with a Pedicled Latissimus Dorsi Myocutaneous Flap for Myxofibrosarcoma of the Arm. ( 25426346 )
2014
38
Head and neck myxofibrosarcoma: a case report and review of the literature. ( 25547541 )
2014
39
Myxofibrosarcoma with associated Mycobacterium infection. ( 24966999 )
2014
40
Myxofibrosarcoma arising in a burn scar. ( 24354641 )
2014
41
The management of myxofibrosarcoma - a ten-year experience in a single specialist centre. ( 26280619 )
2014
42
Impact of infiltrative growth on the outcome of patients with undifferentiated pleomorphic sarcoma and myxofibrosarcoma. ( 24975462 )
2014
43
An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. ( 25172220 )
2014
44
Appearance of recurrent cardiac myxofibrosarcoma on FDG PET/CT. ( 24662649 )
2014
45
Myxofibrosarcoma directly invading superior vena cava causing obstruction successfully relieved by endovascular stent. ( 25365347 )
2014
46
Primary intermediate-grade cardiac myxofibrosarcoma with osseous metaplasia: an extremely rare occurrence with a previously unreported feature. ( 25246023 )
2014
47
Orbital myxofibrosarcoma: a clinicopathologic correlation of an extremely rare tumor. ( 24833459 )
2014
48
Myxofibrosarcoma of the thyroid gland. ( 24702999 )
2014
49
AMACR amplification in myxofibrosarcomas: a mechanism of overexpression that promotes cell proliferation with therapeutic relevance. ( 25384383 )
2014
50
Myxofibrosarcoma arising from a chronic burn scar. ( 24506764 )
2014

Variations for Myxofibrosarcoma

Copy number variations for Myxofibrosarcoma from CNVD:

7 (show all 47)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 29705 1 234600000 241700000 Loss AKT3 Myxofibrosarcoma
2 38875 10 105700000 114900000 Loss FACL5 Myxofibrosarcoma
3 39423 10 114900000 127400000 Loss DMBT1 Myxofibrosarcoma
4 42687 10 3800000 6700000 Loss DNMT2 Myxofibrosarcoma
5 47803 10 98000000 105700000 Loss HOX11 Myxofibrosarcoma
6 47805 10 98000000 105700000 Loss PLAU Myxofibrosarcoma
7 49687 11 110000000 120700000 Loss PIG8 Myxofibrosarcoma
8 51757 11 130300000 134452384 Loss ADAMTS8 Myxofibrosarcoma
9 54382 11 43400000 48800000 Loss KAI1 Myxofibrosarcoma
10 61474 12 1 14800000 Gain CCND2 Myxofibrosarcoma
11 61522 12 1 33200000 Loss LRP6 Myxofibrosarcoma
12 66186 12 26300000 33200000 Gain KRAG Myxofibrosarcoma
13 70913 12 66000000 69800000 Gain HMGIC Myxofibrosarcoma
14 73112 12 91200000 94800000 Loss BTG1 Myxofibrosarcoma
15 108897 17 23200000 35400000 Loss LIG3 Myxofibrosarcoma
16 115128 17 54900000 59900000 Gain TBX2 Myxofibrosarcoma
17 124176 19 1 6900000 Gain SH3GL1 Myxofibrosarcoma
18 143681 2 23900000 31900000 Loss ALK Myxofibrosarcoma
19 147727 2 69800000 136600000 Loss CXCR4 Myxofibrosarcoma
20 148303 2 75400000 83700000 Loss REG1A Myxofibrosarcoma
21 151117 20 17800000 27100000 Loss JAG1 Myxofibrosarcoma
22 170894 3 161200000 184200000 Loss MDS1 Myxofibrosarcoma
23 177567 3 58500000 63700000 Loss FHIT Myxofibrosarcoma
24 186568 4 36900000 114100000 Loss IBSP Myxofibrosarcoma
25 187541 4 50700000 52400000 Gain AFP Myxofibrosarcoma
26 208064 6 164400000 170899992 Loss PDCD2 Myxofibrosarcoma
27 217848 7 104755715 105039798 Amplificationlication SRPK2 Myxofibrosarcoma
28 217923 7 105888733 105925638 Amplificationlication PBEF1 Myxofibrosarcoma
29 218114 7 107788083 108096826 Amplificationlication NRCAM Myxofibrosarcoma
30 218692 7 116312458 116438439 Amplificationlication MET Myxofibrosarcoma
31 219052 7 121513158 121702088 Amplificationlication PTPRZ1 Myxofibrosarcoma
32 219257 7 124462440 124570037 Amplificationlication POT1 Myxofibrosarcoma
33 219480 7 127292201 127732658 Amplificationlication SND1 Myxofibrosarcoma
34 219953 7 132400000 147500000 Gain TIM1 Myxofibrosarcoma
35 223288 7 1855427 2272583 Amplificationlicatio n MAD1L1 Myxofibrosarcoma
36 225548 7 47314752 47621742 Amplification TNS3 Myxofibrosarcoma
37 228044 7 73245192 73247014 Amplificationlicatio n CLDN4 Myxofibrosarcoma
38 228772 7 81331444 81399452 Amplificationlicatio n HGF Myxofibrosarcoma
39 229104 7 87257728 87461612 Amplificationlicatio n RPIP9 Myxofibrosarcoma
40 229332 7 90095737 90839904 Amplificationlicatio n PFTK1 Myxofibrosarcoma
41 229600 7 92234236 92465941 Amplificationlicatio n CDK6 Myxofibrosarcoma
42 234953 8 140000000 146274826 Gain TG Myxofibrosarcoma
43 242385 8 7200000 43200000 Gain POLB Myxofibrosarcoma
44 262150 X 31500000 37500000 Gain OTC Myxofibrosarcoma
45 264432 X 65100000 67700000 Gain ED1 Myxofibrosarcoma
46 264546 X 67700000 72200000 Gain TED Myxofibrosarcoma
47 266520 X 98200000 110500000 Loss PLP Myxofibrosarcoma

Expression for Myxofibrosarcoma

Search GEO for disease gene expression data for Myxofibrosarcoma.

Pathways for Myxofibrosarcoma

Pathways related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.64 CCNA2 CREB3L1 CREB3L2
2
Show member pathways
11.34 CCNA2 CD36 CREB3L1 CREB3L2
3
Show member pathways
11.17 CD36 CREB3L1 CREB3L2
4 11.11 CREB3L1 CREB3L2
5 10.9 CREB3L1 CREB3L2

GO Terms for Myxofibrosarcoma

Biological processes related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to unfolded protein GO:0006986 9.16 CREB3L1 CREB3L2
2 endoplasmic reticulum unfolded protein response GO:0030968 8.96 CREB3L1 CREB3L2
3 animal organ regeneration GO:0031100 8.62 CCNA2 MKI67

Molecular functions related to Myxofibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cAMP response element binding GO:0035497 8.62 CREB3L1 CREB3L2

Sources for Myxofibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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