MCID: MYX013
MIFTS: 45

Myxofibrosarcoma malady

Neuronal, Cancer categories

Summaries for Myxofibrosarcoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A sarcoma (from the Greek σάρξ sarx meaning \"flesh\") is a cancer that arises from transformed... more...

MalaCards: Myxofibrosarcoma, also known as myxoid dermatofibrosarcoma protuberans, is related to fibrous histiocytoma and myxoid liposarcoma. An important gene associated with Myxofibrosarcoma is FUS (fused in sarcoma), and among its related pathways are Signaling by VEGF and Vasopressin-regulated water reabsorption. The compounds cycloheximide and orcein have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are embryogenesis and homeostasis/metabolism.

Aliases & Classifications for Myxofibrosarcoma

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
myxoid malignant fibrous histiocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

myxofibrosarcoma 49
myxoid dermatofibrosarcoma protuberans 61
myxoid malignant fibrous histiocytoma 49
fibromyxosarcoma 49


External Ids:

ICD10 via Orphanet26 C49

Related Diseases for Myxofibrosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma30.2FUS
2myxoid liposarcoma30.2CREB3L2
3cutaneous fibrous histiocytoma29.9S100B, DES
4dermatofibrosarcoma protuberans29.9VIM, S100B, DES
5pleomorphic liposarcoma10.4
6papular mucinosis10.4
7pleomorphic malignant fibrous histiocytoma10.4
8multiple myeloma10.0CKS1B
9acute leukemia10.0CCNA2
10syringoma10.0S100B
11glomerulonephritis10.0MME
12benign meningioma10.0CCNA2
13schizophrenia10.0S100B
14peripheral primitive neuroectodermal tumor10.0FUS
15fibrous meningioma10.0S100B
16hepatitis c10.0CD209
17infantile myofibromatosis10.0DES
18myocardial infarction10.0MME
19lymphangioleiomyomatosis10.0DES
20medulloblastoma10.0DES, S100B
21pulmonary fibrosis10.0CD36
22extraskeletal myxoid chondrosarcoma10.0CREB3L2
23bladder carcinoma10.0CCNA2, THBS1
24hypertension10.0MME
25myeloid leukemia10.0CCNA2, CDK1
26uterine sarcoma10.0MME, DES
27retinopathy of prematurity10.0FLT1
28cystadenoma10.0MME
29laryngeal squamous cell carcinoma10.0SKP2, CCNA2
30pituitary adenoma10.0GNAS
31perineurioma10.0VIM, S100B
32hemangioma10.0THBS1, KDR
33angiomyolipoma10.0VIM, DES
34age related macular degeneration10.0FLT1
35arthritis10.0THBS1, FLT1
36herpes simplex10.0THBS1
37lipoma10.0FUS, DES
38glomus tumor10.0DES, VIM
39epithelioid leiomyosarcoma10.0DES, VIM
40proteinuria10.0FLT1, KDR
41mesenchymal chondrosarcoma10.0DES, VIM
42leydig cell tumor10.0GNAS
43oral cancer10.0SKP2, CDK1, CCNA2
44pheochromocytoma10.0CCNA2, GNAS
45pseudosarcomatous fibromatosis10.0VIM, DES
46malaria10.0KDR, CD36
47spindle cell carcinoma10.0DES, VIM
48intracranial hemorrhage in brain cerebrovascular malformations10.0FLT1, KDR
49amelanotic melanoma10.0S100B, THBS1
50clear cell sarcoma10.0FUS, S100B

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to myxofibrosarcoma

Clinical Features for Myxofibrosarcoma

Drugs & Therapeutics for Myxofibrosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Myxofibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Myxofibrosarcoma

Search NIH Clinical Center for Myxofibrosarcoma

Search CenterWatch for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

Anatomical Context for Myxofibrosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Myxofibrosarcoma:

33
Brain, Heart, Skeletal muscle, Colon, Lung, Breast, Skin, Prostate

Animal Models for Myxofibrosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myxofibrosarcoma

Sources:
51PubMed
See all sources

Articles related to Myxofibrosarcoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Myxofibrosarcoma arising in a burn scar. (24354641)
2014
2
An analysis of factors related to recurrence of myxofibrosarcoma. (23969617)
2013
3
Myxofibrosarcoma: prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging. (23318907)
2013
4
The novel myxofibrosarcoma cell line MUG-Myx1 expresses a tumourigenic stem-like cell population with high aldehyde dehydrogenase 1 activity. (24289252)
2013
5
Superficial myxofibrosarcoma: assessment of recurrence risk according to the surgical margin following resection. A series of 21 patients. (23602311)
2013
6
Pleomorphic hyalinizing angiectatic tumor: a report of 3 new cases, 1 with sarcomatous myxofibrosarcoma component and another with unreported soft tissue palpebral location. (22024990)
2012
7
Myxofibrosarcoma: cytomorphologic findings and differential diagnosis on fine needle aspiration. (22236741)
2012
8
Myxofibrosarcoma of the infratemporal space. (21768709)
2011
9
Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. (20878245)
2011
10
Low-grade myxofibrosarcoma presenting at the site of prior high-grade disease. (21752050)
2011
11
Biology, classification, and management of recurrent myxofibrosarcoma 21 years after resection. (22263212)
2011
12
Bone and/or joint attachment is a risk factor for local recurrence of myxofibrosarcoma. (21611802)
2011
13
Multiple statistical analysis techniques corroborate intratumor heterogeneity in imaging mass spectrometry datasets of myxofibrosarcoma. (21980364)
2011
14
Fine-needle aspiration in myxofibrosarcoma: experience of Institut Curie. (19899126)
2010
15
Myxofibrosarcoma mimicking cutaneous myxoma. (19788445)
2010
16
CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma. (20175824)
2010
17
Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis. (20639860)
2010
18
Anatomical reconstruction of the knee extensor apparatus for prepatellar myxofibrosarcoma. (20954649)
2010
19
Large obstructive cardiac myxofibrosarcoma is nearly invisible on transthoracic echocardiogram. (19490014)
2009
20
Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix. (19320777)
2009
21
Thallium-201 scintigraphy of myxofibrosarcoma. (20139844)
2009
22
Myxofibrosarcoma in the skin. (18494817)
2008
23
Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding. (18701294)
2008
24
Histopathological evolution of a cutaneous myxofibrosarcoma. (18638228)
2008
25
Primary myxofibrosarcoma of the left atrium: case report and review of the literature. (18388050)
2008
26
FDG PET imaging of myxofibrosarcoma on the sphenoid sinus. (18496453)
2008
27
Low-grade myxofibrosarcoma: CT and MRI patterns in recurrent disease. (17242227)
2007
28
Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. (17197925)
2007
29
Low-grade myxofibrosarcoma invaded into the underlying skeletal muscle. (17683388)
2007
30
Myxofibrosarcoma of the neck. (17038234)
2006
31
Adult paratesticular myxofibrosarcoma: report of a rare entity and review of the literature. (16502045)
2006
32
Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. (16801862)
2006
33
Myxofibrosarcoma of the hypopharynx. (16183234)
2006
34
Primary cutaneous myxofibrosarcoma mimicking pleomorphic hyalinizing angiectatic tumor (PHAT): a potential diagnostic pitfall. (16121054)
2005
35
Establishment and characterization of a novel myxofibrosarcoma cell line. (16080955)
2005
36
Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation. (15832195)
2005
37
Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. (16008697)
2005
38
Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. (15138937)
2004
39
Myxofibrosarcomas contain large numbers of infiltrating immature dendritic cells. (12710126)
2003
40
Primary myxofibrosarcoma of the esophagus. (12091833)
2002
41
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. (11213831)
2001
42
Translocation (2;15)(p23;q21.2) and interstitial deletion of 7q in a case of low-grade myxofibrosarcoma. (11425453)
2001
43
Myxofibrosarcoma with an infiltrative growth pattern: a case report. (11185894)
2000
44
Myxofibrosarcoma of the lower extremity. A case report. (3941378)
1986
45
Myxofibrosarcoma in a Roosevelt elk (cervus elaphus roosevelti). (6879958)
1983
46
Myxofibrosarcoma of the maxillary sinus. (7067862)
1982
47
Myxofibrosarcoma. A study of 30 cases. (15396)
1977
48
Myxofibrosarcoma: a pathologico-anatomical, microangiographic and angiographic correlative study of eight cases. (588917)
1977
49
Central myxofibrosarcoma of the mandible treated by radical resection. (1056575)
1975
50
SOME OBSERVATIONS ON NUTRITION OF A HUMAN MYXOFIBROSARCOMA CELL LINE (HFS) CULTIVATED IN VITRO. (14222786)
1964

Genetic Variations for Myxofibrosarcoma

Expression for genes affiliated with Myxofibrosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Myxofibrosarcoma

Search GEO for disease gene expression data for Myxofibrosarcoma.

Pathways for genes affiliated with Myxofibrosarcoma

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9KDR, FLT1
29.7GNAS, CREB3L1, CREB3L2
39.7KDR, FLT1, CCNA2
4
Hide members
9.6CCNA2, CDK1
5
Hide members
9.6CCNA2, CDK1
69.6KDR, FLT1, MET
79.6THBS1, CD36, MET
89.5CCNA2, MET, SKP2
9
Hide members
9.5MCM7, CKS1B
10
Development Endothelin-1/EDNRA signaling
Hide members
9.5KDR, CREB3L2, CREB3L1, GNAS
119.1CCNA2, CDK1, MCM7
12
Hide members
9.1VIM, CCNA2, MET, FLT1, KDR
139.0SKP2, CDK1, CKS1B
148.9SKP2, CDK1, CCNA2, VIM
15
Hide members
8.8THBS1, CDK1, CDK6
168.8SKP2, CDK6, CKS1B
178.8CKS1B, CCNA2, CDK1, SKP2
188.8THBS1, CDK6, MET, VIM
19
Hide members
8.7CREB3L1, CREB3L2, MET, CDK6, THBS1
20
Hide members
8.7CCNA2, GNAS, CREB3L1, CREB3L2, CDK6
21
Hide members
8.6SKP2, CDK6, CCNA2, CKS1B
22
Hide members
8.5MET, FLT1, CDK6, KDR, THBS1
23
Hide members
8.5SKP2, MCM7, CDK6, CCNA2
248.1CREB3L1, CREB3L2, MET, FLT1, CDK6, KDR
258.0CCNA2, CREB3L1, CREB3L2, CDK6, CDK1, SKP2
26
Cell cycle Cell cycle (generic schema)
Hide members
7.9CKS1B, CCNA2, CDK6, CDK1, SKP2
27
Hide members
7.9CCNA2, CDK6, CDK1, MCM7, SKP2
28
Hide members
7.6VIM, CKS1B, CCNA2, CDK1, CD36, MCM7
29
Hide members
7.2SKP2, CKS1B, CCNA2, CREB3L1, CDK6, CDK1

Compounds for genes affiliated with Myxofibrosarcoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5MME
2orcein4510.1S100B, VIM, DES
3s 1004510.0VIM, DES, S100B
4dexamethasone45 50 29 1112.7MME, CCNA2, CD209, S100B, KDR
5glucose459.7THBS1, FLT1, MET
6bromodeoxyuridine459.5CCNA2, MME, DES, S100B, VIM
7hematoxylin459.5S100B, DES, VIM, FLT1
8amsacrine45 1110.3CDK1, CCNA2, VIM
9paclitaxel45 50 1111.3THBS1, KDR, S100B, CDK1, CCNA2
10heparan sulfate45 2410.3THBS1, KDR, DES, MET, VIM
11heparin45 29 11 2412.2FLT1, DES, CDK1, S100B, CD36
12p002459.2MET, FLT1, SKP2, DES, GNAS
13hydroxyapatite459.1CD36, VIM, S100B, THBS1
14cytarabine45 50 1111.1VIM, CCNA2, CDK1, CD36, MME
15methionine458.9S100B, DES, VIM, CDK1, THBS1, MME
16monensin458.9CCNA2, CDK1, CDK6, THBS1
17dmso458.9CCNA2, CDK1, CD36, THBS1, VIM
18matrigel458.9THBS1, VIM, MET, FLT1, CD36, MME
19adriamycin458.8VIM, MET, MME, CD36, DES, CDK1
20sb 20358045 609.8CDK1, VIM, CD36, THBS1, CCNA2, FLT1
21serine458.7S100B, FLT1, GNAS, THBS1, CDK1, DES
22roscovitine458.7CDK1, CDK6, CCNA2, VIM
23glycogen45 249.7S100B, CDK1, DES, CCNA2, MET, VIM
24wortmannin458.7MET, CDK1, KDR, S100B, VIM, THBS1
2512-o-tetradecanoylphorbol 13-acetate458.7VIM, CCNA2, MET, THBS1, DES, CDK1
26arginine458.6VIM, CCNA2, GNAS, MET, DES, MME
27adenylate458.6MME, CDK1, DES, VIM, CCNA2, S100B
28cyclic amp45 249.5CDK1, CREB3L2, VIM, CCNA2, S100B, GNAS
29nitric oxide45 11 2410.4MME, CCNA2, S100B, GNAS, MET, FLT1
30tgf beta1458.4FLT1, CCNA2, THBS1, KDR, CD36, CDK6
31testosterone45 60 11 2411.4MET, S100B, CDK1, MME, THBS1, CCNA2
32rottlerin458.4CDK6, CDK1, CCNA2, CD36
33cysteine458.3THBS1, KDR, DES, MET, GNAS, S100B
34genistein45 29 60 2 11 2413.3CD36, CDK1, FLT1, KDR, MET, CCNA2
35h2o2458.2VIM, CDK1, THBS1, CD36, DES, MME
36doxorubicin45 50 1110.1MME, KDR, CDK1, DES, FLT1, MET
37proline458.1CDK1, S100B, VIM, MET, DES, CDK6
38lipid457.8CDK1, FLT1, MET, GNAS, CCNA2, VIM
39threonine457.7GNAS, MET, S100B, CCNA2, CDK6, DES
40ly294002457.6SKP2, CCNA2, CDK6, CD36, MET, KDR
41alanine457.6CDK1, CDK6, CCNA2, S100B, GNAS, MET
42vegf457.6S100B, THBS1, MME, CD36, CDK1, DES
43progesterone45 60 29 11 2411.4VIM, S100B, GNAS, MET, FLT1, DES
44rapamycin457.4SKP2, KDR, CDK1, MET, VIM, CDK6
45oxygen45 248.3CCNA2, FLT1, DES, CDK6, CDK1, MME
46paraffin457.2CD36, THBS1, KDR, SKP2, MME, CDK1
47thymidine45 248.1S100B, GNAS, MET, FLT1, DES, CDK6
48calcium45 50 11 249.7FLT1, CD36, CDK1, DES, MME, THBS1
49retinoic acid45 247.7CDK6, VIM, CCNA2, S100B, MET, DES
50tyrosine455.9CDK6, DES, CKS1B, CCNA2, S100B, KDR

GO Terms for genes affiliated with Myxofibrosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ruffleGO:0017268.8CDK6, GNAS, S100B
2nucleoplasmGO:0056548.1FUS, SKP2, MCM7, CDK1, CCNA2, CKS1B

Biological processes related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:0301949.9CD36, THBS1
2G1/S transition of mitotic cell cycleGO:0000829.8SKP2, MCM7
3positive regulation of MAPK cascadeGO:0434109.8KDR, CD36, FLT1
4mitotic G2 DNA damage checkpointGO:0070959.7CCNA2, CDK1
5positive regulation of angiogenesisGO:0457669.6FLT1, KDR, THBS1
6astrocyte developmentGO:0140029.4CDK6, VIM
7activation of MAPK activityGO:0001879.3THBS1, CDK1, MET
8cell proliferationGO:0082838.7CKS1B, S100B, MET, MCM7, SKP2
9response to drugGO:0424938.4THBS1, MCM7, CDK1, GNAS
10mitotic cell cycleGO:0002787.6CKS1B, CCNA2, CDK6, CDK1, MCM7, SKP2

Molecular functions related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:0504319.9THBS1, CD36
2vascular endothelial growth factor-activated receptor activityGO:0050219.6KDR, FLT1
3identical protein bindingGO:0428028.5VIM, S100B, FLT1, DES, SKP2, THBS1
4protein bindingGO:0055154.7FUS, VIM, CKS1B, CCNA2, S100B, GNAS

Products for genes affiliated with Myxofibrosarcoma

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Sources for Myxofibrosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet