MCID: MYX013
MIFTS: 45

Myxofibrosarcoma malady

Neuronal diseases, Cancer diseases, Rare diseases, Skin diseases categories

Summaries for Myxofibrosarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A sarcoma (from the Greek ???? sarx meaning \"flesh\") is a cancer that arises from transformed cells of... more...

MalaCards: Myxofibrosarcoma, also known as myxoid dermatofibrosarcoma protuberans, is related to liposarcoma and fibrous histiocytoma. An important gene associated with Myxofibrosarcoma is CREB3L2 (cAMP responsive element binding protein 3-like 2), and among its related pathways are PI3K-Akt signaling pathway and Glioma. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Myxofibrosarcoma

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50Orphanet, 63UMLS, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

50
myxoid malignant fibrous histiocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

myxofibrosarcoma 50
myxoid dermatofibrosarcoma protuberans 63
myxoid malignant fibrous histiocytoma 50
fibromyxosarcoma 50


External Ids:

ICD10 via Orphanet27 C49

Related Diseases for Myxofibrosarcoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Myxofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma30.4FUS, DES
2fibrous histiocytoma30.3FUS
3sarcoma30.2S100B, DES, FUS, CCNA2, CREB3L1, CREB3L2
4myxoid liposarcoma30.1CREB3L2
5dermatofibrosarcoma protuberans30.1DES, S100B
6fibrosarcoma30.0DES, CREB3L2, THBS1
7pleomorphic liposarcoma10.4
8papular mucinosis10.4
9retroperitoneal liposarcoma10.4
10histiocytoma10.1
11fibrous meningioma10.1S100B
12syringoma10.1S100B
13glomus tumor10.1DES
14peripheral primitive neuroectodermal tumor10.1FUS
15extraskeletal myxoid chondrosarcoma10.1CREB3L2
16spindle cell sarcoma10.1S100B, DES
17cutaneous fibrous histiocytoma10.1DES, S100B
18granular cell tumor10.1DES, S100B
19hemangiopericytoma10.1S100B, DES
20sex cord-gonadal stromal tumor10.1S100B, DES
21amelanotic melanoma10.1THBS1, S100B
22malignant mixed mullerian tumor10.1DES, S100B
23myoepithelioma10.1THBS1, S100B
24chordoma10.1DES, S100B
25giant cell tumor10.1DES, S100B
26pleomorphic adenoma10.1S100B, DES
27ganglioneuroma10.1THBS1, S100B
28synovial sarcoma10.1S100B, DES
29pilocytic astrocytoma10.1THBS1, S100B
30gastrointestinal stromal tumor10.1S100B, DES
31clear cell sarcoma10.1S100B, FUS
32uterine fibroid10.1THBS1, DES
33lipoma10.1FUS, DES
34abrikosov's tumor10.1DES, GNAS
35leiomyosarcoma10.1S100B, DES
36intraocular melanoma10.1THBS1, S100B
37neurilemmoma10.1S100B, DES
38smooth muscle tumor10.0DES, S100B, CCNA2
39malignant fibroxanthoma10.0DES, S100B, CCNA2
40anaplastic astrocytoma10.0THBS1, CCNA2
41leiomyoma10.0S100B, DES
42chondrosarcoma10.0DES, S100B, FUS
43astrocytoma10.0CCNA2, THBS1, S100B
44glioblastoma multiforme10.0THBS1, CCNA2, S100B
45papillary carcinoma10.0GNAS, THBS1
46melanoma10.0S100B, DES, THBS1, CCNA2
47burn scar10.0
48burns10.0
49fibroma10.0
50dermatofibrosarcoma10.0

Graphical network of the top 20 diseases related to Myxofibrosarcoma:



Diseases related to myxofibrosarcoma

Symptoms for Myxofibrosarcoma

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Drugs & Therapeutics for Myxofibrosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Myxofibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Myxofibrosarcoma

Search NIH Clinical Center for Myxofibrosarcoma

Search CenterWatch for Myxofibrosarcoma

Genetic Tests for Myxofibrosarcoma

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Anatomical Context for Myxofibrosarcoma

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34MalaCards
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MalaCards organs/tissues related to Myxofibrosarcoma:

34
Lung, Breast, Bone, Colon, Brain, Heart, Skin, Skeletal muscle, Prostate

Animal Models for Myxofibrosarcoma or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Myxofibrosarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.9CREB3L1, CCNA2, GNAS, FUS, THBS1
2MP:00053977.8THBS1, FUS, GNAS, CCNA2, CREB3L1
3MP:00053877.3THBS1, FUS, GNAS, CCNA2, CD209
4MP:00107686.9CD209, CREB3L2, CCNA2, GNAS, FUS, THBS1

Publications for Myxofibrosarcoma

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53PubMed
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Articles related to Myxofibrosarcoma:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Myxofibrosarcoma arising in a burn scar. (24354641)
2014
2
CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall. (23600956)
2013
3
An analysis of factors related to recurrence of myxofibrosarcoma. (23969617)
2013
4
Myxofibrosarcoma: prevalence and diagnostic value of the "tail sign" on magnetic resonance imaging. (23318907)
2013
5
Primary cardiac myxofibrosarcoma: a case report and review of the literature. (23389377)
2012
6
The cytologic diagnosis of epithelioid myxofibrosarcoma: a case report. (22927294)
2012
7
Recurrent amplification at 7q21.2 Targets CDK6 gene in primary myxofibrosarcomas and identifies CDK6 overexpression as an independent adverse prognosticator. (22476749)
2012
8
Myxofibrosarcoma of the orbit: case report and review of literature. (21464787)
2012
9
High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer. (23195821)
2012
10
Characterization of gene amplification-driven SKP2 overexpression in myxofibrosarcoma: potential implications in tumor progression and therapeutics. (22322669)
2012
11
18F-FDG PET/CT imaging of multiple myxofibrosarcoma in left upper abdomen and chest wall. (23250511)
2012
12
Pleomorphic hyalinizing angiectatic tumor: a report of 3 new cases, 1 with sarcomatous myxofibrosarcoma component and another with unreported soft tissue palpebral location. (22024990)
2012
13
Myxofibrosarcoma of the sinus piriformis: case report and literature review. (23152982)
2012
14
Rapid multiorgan dissemination of low-grade myxofibrosarcoma: a case report. (22973315)
2012
15
Myxofibrosarcoma of the infratemporal space. (21768709)
2011
16
A mass of myxofibrosarcoma in the lung. (21554234)
2011
17
Epitheloid myxofibrosarcoma of the parotid gland. (22937388)
2011
18
Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. (20878245)
2011
19
Fine-needle aspiration in myxofibrosarcoma: experience of Institut Curie. (19899126)
2010
20
Myxofibrosarcoma mimicking cutaneous myxoma. (19788445)
2010
21
Primary myxofibrosarcoma of the parotid: case report. (20513245)
2010
22
CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma. (20175824)
2010
23
Myxofibrosarcoma of the orbit: a clinicopathologic case report. (20305519)
2010
24
Palliation of recurrent myxofibrosarcoma with radiotherapy and hyperthermia. (21140105)
2010
25
Primary aortic myxofibrosarcoma mimicking thrombus: findings on CT, MRI, and angiography. (19465836)
2009
26
Large obstructive cardiac myxofibrosarcoma is nearly invisible on transthoracic echocardiogram. (19490014)
2009
27
Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation. (19335880)
2009
28
High-grade infiltrative myxofibrosarcoma in the forearm presenting as acute carpal tunnel syndrome. (18294554)
2008
29
Myxofibrosarcoma of the orbit: an underrecognized entity? Case report and review of the literature. (18096231)
2008
30
Myxofibrosarcoma in the skin. (18494817)
2008
31
Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding. (18701294)
2008
32
Pleomorphic hyalinizing angiectatic tumor with a sarcomatous component recurring as high-grade myxofibrosarcoma. (17493176)
2007
33
Myxofibrosarcoma of the neck. (17038234)
2006
34
Primary cutaneous myxofibrosarcoma mimicking pleomorphic hyalinizing angiectatic tumor (PHAT): a potential diagnostic pitfall. (16121054)
2005
35
Establishment and characterization of a novel myxofibrosarcoma cell line. (16080955)
2005
36
Myxofibrosarcoma of the breast as an unusual variant of malignant fibrous histiocytoma: report of a case. (15338347)
2004
37
Minichromosome maintenance protein in myxofibrosarcoma. (14685255)
2004
38
Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implications. (14608538)
2003
39
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. (11213831)
2001
40
Translocation (2;15)(p23;q21.2) and interstitial deletion of 7q in a case of low-grade myxofibrosarcoma. (11425453)
2001
41
Myxofibrosarcoma of soft tissues: cytomorphologic analysis of a series. (9884819)
1999
42
Cervical myxofibrosarcoma in a renal allograft recipient treated with murine anti-CD3 monoclonal antibody therapy. (9681773)
1998
43
Low-grade myxofibrosarcoma: progression in recurrence. (9088034)
1997
44
Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. (8604805)
1996
45
Myxofibrosarcoma in a Roosevelt elk (cervus elaphus roosevelti). (6879958)
1983
46
Myxofibrosarcoma of the maxillary sinus. (7067862)
1982
47
Myxofibrosarcoma: a correlative cytologic and histologic study of 13 cases examined by fine needle aspiration cytology. (6154396)
1980
48
The ultrastructure of myxofibrosarcoma. A study of 11 cases. (154761)
1979
49
Myxofibrosarcoma. A study of 30 cases. (15396)
1977
50
Myxofibrosarcoma: a pathologico-anatomical, microangiographic and angiographic correlative study of eight cases. (588917)
1977

Variations for Myxofibrosarcoma

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Expression for genes affiliated with Myxofibrosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxofibrosarcoma

Search GEO for disease gene expression data for Myxofibrosarcoma.

Pathways for genes affiliated with Myxofibrosarcoma

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome
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Pathways related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3THBS1, CREB3L1, CREB3L2
2
Show member pathways
Signaling Pathways in Glioblastoma39
9.3THBS1, CREB3L1, CREB3L2
3
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
9.3GNAS, CREB3L1, CREB3L2
4
Show member pathways
9.3GNAS, CREB3L1, CREB3L2
5
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
6
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
79.3CREB3L2, CREB3L1, GNAS
8
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
99.3CREB3L2, CREB3L1, GNAS
10
Show member pathways
9.3CREB3L2, CREB3L1, GNAS
119.1CCNA2, GNAS
129.0CREB3L2, CREB3L1, CCNA2
13
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5GNAS, CCNA2, CREB3L1, CREB3L2

Compounds for genes affiliated with Myxofibrosarcoma

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Myxofibrosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1orcein4610.0S100B, DES
2s 1004610.0DES, S100B
3reticulin4610.0S100B, DES
4mucicarmine4610.0DES, S100B
5b 7234610.0S100B, DES
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.9DES, S100B
7ccl446 3010.7S100B, DES
8hematoxylin469.6S100B, DES
9monensin469.5CCNA2, THBS1
10methionine469.5S100B, THBS1, DES
11hydroxyapatite469.4S100B, THBS1
12norepinephrine46 25 1211.4DES, GNAS, S100B
13bromodeoxyuridine469.2S100B, CCNA2, DES
14polysaccharide469.2THBS1, GNAS, CD209
15gtp46 3010.2THBS1, GNAS, S100B
16gold469.1DES, THBS1, CCNA2
17ethanol46 52 25 1212.1S100B, CCNA2, DES
1812-o-tetradecanoylphorbol 13-acetate469.1CCNA2, THBS1, DES
19heparin46 30 25 1212.1S100B, THBS1, DES
20glycogen46 2510.0DES, CCNA2, S100B
21paclitaxel46 52 1211.0THBS1, CCNA2, S100B
22doxorubicin46 52 1211.0CCNA2, THBS1, DES
23proline469.0DES, CCNA2, S100B
24estradiol46 25 1211.0CCNA2, THBS1, DES
25forskolin46 52 1210.9GNAS, CCNA2, S100B
26cysteine468.9S100B, GNAS, THBS1, DES
27cyclosporin a46 30 6210.8S100B, CCNA2, THBS1
28leucine468.8FUS, GNAS, S100B
29dopamine46 30 25 1211.7GNAS, CCNA2, S100B
30paraffin468.7S100B, CCNA2, THBS1, DES
31adenylate468.7DES, GNAS, CCNA2, S100B
32testosterone46 62 25 1211.7DES, THBS1, CCNA2, S100B
33steroid468.7S100B, CCNA2, GNAS, DES
34vegf468.6S100B, CCNA2, THBS1, DES
35arginine468.6DES, GNAS, CCNA2, S100B
36estrogen468.6S100B, CCNA2, THBS1, DES
37retinoic acid46 259.6DES, THBS1, CCNA2, S100B
38alanine468.5THBS1, GNAS, CCNA2, S100B
39dexamethasone46 52 30 1211.4THBS1, CCNA2, S100B, CD209
40thymidine46 259.2DES, THBS1, GNAS, CCNA2, S100B
41progesterone46 30 62 25 1212.2DES, THBS1, GNAS, CCNA2, S100B
42nitric oxide46 25 1210.2S100B, CCNA2, GNAS, THBS1, DES
43threonine468.2DES, THBS1, GNAS, CCNA2, S100B
44oxygen46 259.2DES, THBS1, GNAS, CCNA2, S100B
45glucose468.2DES, THBS1, GNAS, CCNA2, S100B
46serine468.1DES, THBS1, GNAS, CCNA2, S100B
47cyclic amp46 259.1S100B, CREB3L2, CREB3L1, CCNA2, GNAS, DES
48lipid468.0THBS1, GNAS, CCNA2, S100B, CD209
49tyrosine467.6DES, THBS1, GNAS, CCNA2, S100B, CD209
50calcium46 52 25 1210.5DES, THBS1, GNAS, CCNA2, S100B, CD209

GO Terms for genes affiliated with Myxofibrosarcoma

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17Gene Ontology
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Biological processes related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cartilage developmentGO:0512169.6CREB3L2, GNAS
2response to endoplasmic reticulum stressGO:0349769.3CREB3L2, THBS1
3response to unfolded proteinGO:0069869.2CREB3L2, CREB3L1, THBS1

Molecular functions related to Myxofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.7S100B, FUS, THBS1, DES

Products for genes affiliated with Myxofibrosarcoma

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Sources for Myxofibrosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet