Myxoid Chondrosarcoma malady

Wikipedia: Myxoid chondrosarcoma is a type of sarcoma.⁴⁴ more...

MalaCards: Myxoid Chondrosarcoma, also known as myxoid chondrosarcoma (morphologic abnormality), is related to extraskeletal myxoid chondrosarcoma and parachordoma. An important gene associated with Myxoid Chondrosarcoma is NR4A3 (nuclear receptor subfamily 4, group A, member 3). The compounds nor 1 and toluidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid and t cells, and related mouse phenotypes are hematopoietic system and behavior/neurological.

Aliases & Descriptions:

myxoid chondrosarcoma 6 43 myxoid chondrosarcoma (morphologic abnormality) 6

Diseases related to myxoid chondrosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 280)

id	Related Disease	Score	Top Affiliating Genes
1	extraskeletal myxoid chondrosarcoma	37.3	NR4A3, TFG, TAF15
2	parachordoma	29.7	VIM, MUC1, S100B, MYH11
3	chordoma	26.6	VIM, MUC1, MTAP, S100A1, S100B, CDKN2B
4	soft tissue sarcoma	26.1	VIM, MTAP, S100B, CDKN2B, CDKN2A, EWSR1
5	chondrosarcoma	25.7	VIM, CHI3L1, MUC1, MTAP, S100A1, S100B
6	thyroiditis	23.4	VIM, MUC1, S100A1, S100B, FUS, CD36
7	sarcoma	21.5	VIM, MUC1, MTAP, S100A1, S100B, FUS
8	langerhans-cell histiocytosis	13.5	S100A1, S100B
9	extraosseous ewing's sarcoma	13.5	S100B, EWSR1
10	desmoplastic small round cell tumor	13.5	MUC1, EWSR1
11	meningeal melanocytoma	13.4	S100B, ENO2
12	retroperitoneal leiomyosarcoma	13.4	S100A1, SMARCB1
13	askin's tumor	13.4	S100B, ENO2
14	central nervous system hemangioblastoma	13.4	MUC1, PLAGL1
15	kidney clear cell sarcoma	13.4	S100B, FUS, EWSR1
16	lung benign neoplasm	13.4	VIM, ENO2
17	fibrous meningioma	13.4	MUC1, S100B
18	intraneural perineurioma	13.4	MUC1, S100B
19	clear cell ependymoma	13.3	VIM, MUC1
20	prostate stromal sarcoma	13.3	VIM, MUC1
21	choroid plexus carcinoma	13.3	VIM, SMARCB1
22	adenoid squamous cell carcinoma	13.3	VIM, MUC1
23	clear cell meningioma	13.3	VIM, MUC1
24	epithelioid malignant peripheral nerve sheath tumor	13.3	S100B, SMARCB1
25	salivary adenoma	13.3	VIM, S100B
26	papillary cystic tumor	13.3	VIM, ENO2
27	mesenchymal chondrosarcoma	13.3	VIM, MUC1
28	nodular hidradenoma	13.3	VIM, MUC1
29	osteoblastoma	13.3	VIM, MUC1
30	epithelioid leiomyosarcoma	13.3	VIM, ENO2
31	pleomorphic liposarcoma	13.2	VIM, FUS
32	melanotic neuroectodermal tumor	13.2	VIM, ENO2
33	olfactory neuroblastoma	13.2	VIM, S100B, EWSR1
34	cellular schwannoma	13.2	VIM, S100A1, S100B
35	ossifying fibromyxoid tumor	13.2	VIM, S100A1, S100B
36	orbit rhabdomyosarcoma	13.2	VIM, ENO2
37	sweat gland carcinoma	13.2	MUC1, S100A1, S100B
38	congenital epulis	13.2	VIM, S100B, ENO2
39	congenital granular cell tumor	13.2	VIM, S100B, ENO2
40	bednar's tumor	13.2	VIM, S100B, ENO2
41	epulis	13.2	VIM, S100B, ENO2
42	creutzfeldt-jakob syndrome	13.2	S100B, ENO2, MAPT
43	fibrous histiocytoma	13.2	VIM, S100B, FUS
44	anaplastic ependymoma	13.2	MUC1, S100B
45	choroid plexus papilloma	13.2	MUC1, S100B
46	bone cancer	13.2	CD36, ENO2, EWSR1
47	sarcomatoid mesothelioma	13.2	VIM, MUC1, S100A1
48	sarcomatoid renal cell carcinoma	13.2	VIM, MUC1, S100A1
49	rectum sarcomatoid carcinoma	13.2	VIM, MUC1
50	clear cell chondrosarcoma	13.1	VIM, CD36

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myxoid chondrosarcoma:

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MGI Mouse Phenotypes related to myxoid chondrosarcoma:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	8.8	TSN, SMARCB1, NR4A3, EWSR1, CDKN2B, FUS
2	behavior/neurological phenotype	MP:0005386	8.2	TSN, NR4A3, ESRRB, MAPT, ENO2, ASS1
3	immune system phenotype	MP:0005387	7.9	TSN, SMARCB1, NR4A3, EWSR1, MAPT, CDKN2B
4	mortality/aging	MP:0010768	7.4	NR4A3, SMARCB1, PLAGL1, SIX3, MYH11, ESRRB
5	tumorigenesis	MP:0002006	7.4	PRKCA, SMARCB1, NR4A3, EWSR1, MAPT, CDKN2A
6	muscle phenotype	MP:0005369	7.2	MYH11, PRKCA, NR1H2, EWSR1, MAPT, CDKN2A
7	vision/eye phenotype	MP:0005391	7.2	SIX3, SMARCB1, MAPT, ASS1, CDKN2A, CD36
8	growth/size phenotype	MP:0005378	6.9	TSN, PLAGL1, SMARCB1, NR4A3, ESRRB, EWSR1
9	integument phenotype	MP:0010771	6.4	MUC1, MYH11, PRKCA, PLAGL1, NR4A3, NR1H2
10	nervous system phenotype	MP:0003631	6.2	NR4A3, SMARCB1, PLAGL1, PRPH, PRKCA, SIX3
11	cellular phenotype	MP:0005384	5.9	EWSR1, NR1H2, NR4A3, SMARCB1, PLAGL1, TSN

Articles related to myxoid chondrosarcoma:

(show all 30)

id	Title	Authors	Year	Affiliating Genes
1	Myxoid chondrosarcoma of the phalanx with an EWS tran slocation: a case report and review of the literature. (21411698)	Bumpass D.B.... Goldfarb C.A.	2011	EWSR1
2	Fluorescence in situ hybridization analysis of extras keletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes. (19775727)	Noguchi H.... Hasegawa T.	2010	EWSR1, NR4A3
3	Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma. (18587326)	Wang W.L.... Lazar A.J.	2008	EWSR1
4	SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma. (18580682)	Kohashi K.... Tsuneyoshi M.	2008	SMARCB1, EWSR1
5	Targeting the mammalian target of rapamycin in myxoid chondrosarcoma. (18827568)	Merimsky O.... Sagi-Eisenberg R.	2008	PRKCA
6	Retroperitoneal extraskeletal myxoid chondrosarcoma (17175793)	Fornari A.	2006	ENO2
7	The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors. (16112421)	Poulin H.... Labelle Y.	2005	PLAGL1, EWSR1
8	TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. (15188455)	Hisaoka M.... Hashimoto H.	2004	TFG
9	Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype. (14657948)	Aigner T.... Nascimento A.G.	2004	S100B, CD36
10	Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes. (15262426)	Hisaoka M.... Hashimoto H.	2004	ESRRB, NR4A3, SIX3
11	The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. (12543801)	Laflamme C.... Labelle Y.	2003	NR1H2, NR4A3, SIX3
12	Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses. (12598313)	Sjogren H.... Stenman G.	2003	CHI3L1
13	Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. (12378528)	Panagopoulos I.... Mandahl N.	2002	EWSR1, TAF15, NR4A3
14	Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation. (11737310)	Goh Y.W.... Nascimento A.G.	2001	VIM, MUC1, S100A1
15	Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). (11156374)	Sjogren H.... Kindblom J.M.	2000	EWSR1, TAF15, NR4A3
16	Expression of the intermediate filament peripherin in extraskeletal myxoid chondrosarcoma. (10728817)	Cummings T.J.... Prieto V.G.	2000	PRPH
17	Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2). (10895826)	Harris M.... Telford N.	2000	TAF15
18	Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. (10602520)	Attwooll C.... Varley J.M.	1999	EWSR1
19	Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma. (10478665)	Folpe A.L.... Weiss S.W.	1999	MYH11
20	Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors. (10439798)	Hu B.... French S.W.	1999	MAPT
21	Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). (10602519)	Panagopoulos I.... Heim S.	1999	FUS, EWSR1, TAF15
22	Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. (10537274)	Sjogren H.... Stenman G.	1999	EWSR1, TAF15, NR4A3
23	Skeletal and extraskeletal myxoid chondrosarcoma: related or distinct tumors? (10410173)	Rubin B.P.... Fletcher J.A.	1999	EWSR1, NR4A3
24	Skeletal and extraskeletal myxoid chondrosarcoma: a comparative clinicopathologic, ultrastructural, and molecular study. (9781944)	Antonescu C.R.... Huvos A.G.	1998	EWSR1, NR4A3
25	Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma. (9060841)	Brody R.I.... Ladanyi M.	1997	EWSR1
26	Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. (8570200)	Clark J.... Cooper C.S.	1996	EWSR1, NR4A3
27	Partial deletions of the CDKN2 and MTS2 putative tumor suppressor genes in a myxoid chondrosarcoma. (8689636)	Jagasia A.A.... Iyer A.P.	1996	CDKN2A, MTAP, CDKN2B
28	Translocation t(9;22)(q22;q12) is a primary cytogenetic abnormality in extraskeletal myxoid chondrosarcoma. (7635565)	Stenman G.... Kindblom L.G.	1995	EWSR1
29	Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma. (7539287)	Gill S.... Shipley J.M.	1995	EWSR1
30	Molecular analysis of a myxoid chondrosarcoma with re arrangements of chromosomes 10 and 22. (1969328)	Shen W.P.... Katz J.	1990	ASS1

Genes related to myxoid chondrosarcoma according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	NR4A3	nuclear receptor subfamily 4, group A, member 3	11.1	Summaries, Functions, Publications
2	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	11.1	Summaries, Publications
3	SIX3	SIX homeobox 3	11.0	Publications
4	PRPH	peripherin	11.0	Publications
5	TDRKH	tudor and KH domain containing	11.0	Publications
6	TSN	translin	11.0	Publications
7	TFG	TRK-fused gene	11.0	Publications
8	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
9	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
10	S100A1	S100 calcium binding protein A1	11.0	Publications
11	PLAGL1	pleiomorphic adenoma gene-like 1	11.0	Publications
12	ESRRB	estrogen-related receptor beta	11.0	Publications
13	FUS	fused in sarcoma	11.0	Publications
14	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
15	S100B	S100 calcium binding protein B	11.0	Publications
16	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
17	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
18	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
19	MAPT	microtubule-associated protein tau	11.0	Publications, Functions
20	VIM	vimentin	11.0	Publications
21	MUC1	mucin 1, cell surface associated	11.0	Publications
22	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
23	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
24	ASS1	argininosuccinate synthase 1	11.0	Publications
25	MTAP	methylthioadenosine phosphorylase	11.0	Publications
26	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
27	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
28	PRKCA	protein kinase C, alpha	11.0	Publications

Compounds related to myxoid chondrosarcoma according to GeneDecks:

(show top 50)    (show all 63)

id	Compound	Score	Top Affiliating Genes
1	nor 132	10.4	EWSR1, ESRRB, NR4A3
2	toluidine32	10.0	ENO2, S100A1, VIM
3	askin32	10.0	ENO2, EWSR1
4	eosin32	10.0	VIM, MUC1, S100B
5	reticulin32	9.9	S100B, MUC1, VIM
6	mucicarmine32	9.8	S100B, S100A1, MUC1, VIM
7	gnrh32	9.8	NR1H2, ESRRB, VIM
8	b 72332	9.8	S100B, S100A1, MUC1, VIM
9	s 10032	9.7	ENO2, S100B, MUC1, VIM
10	4-hydroxytamoxifen32	9.7	NR1H2, ESRRB, S100B, VIM
11	phosphatidylserine32 9 9	11.6	VIM, MAPT, PRKCA
12	hyaluronic acid32 18	10.4	ENO2, CD36, MUC1, CHI3L1, VIM
13	choline32 9 18 9	12.2	PRKCA, MAPT, ENO2, S100B, VIM
14	formaldehyde32 18	10.1	NR1H2, MAPT, ENO2, S100B, MUC1, VIM
15	silver32	9.1	S100A1, CDKN2A, ENO2, MAPT
16	glycogen32 18	10.1	MAPT, ENO2, S100B, S100A1, MUC1, VIM
17	acetylcholine32 9 18 9	12.0	VIM, S100A1, S100B, ENO2, MAPT, PRKCA
18	zinc32 18	10.0	PLAGL1, NR1H2, ESRRB, EWSR1, MAPT, FUS
19	aspartate32	8.9	VIM, S100B, CDKN2A, PRKCA
20	dmso32	8.9	PRKCA, ENO2, CD36, MUC1, VIM
21	glutamine32	8.9	EWSR1, MAPT, ENO2, CD36, S100B, VIM
22	hydrocortisone32 9 9	10.9	NR1H2, CD36, MUC1, VIM
23	tamoxifen32 34 9 9	11.8	VIM, MUC1, ESRRB, NR1H2, PRKCA
24	folate32	8.7	NR1H2, MAPT, CDKN2A, MUC1, VIM
25	biotin32 9 18 9	11.7	CDKN2A, S100A1, MUC1, VIM
26	estrogen32	8.7	CHI3L1, MYH11, PRKCA, ESRRB, MAPT, CD36
27	valine32	8.5	PRKCA, MAPT, CDKN2A, S100B, VIM
28	5-methylthioadenosine32	8.5	ISG20, CDKN2A, CDKN2B, MTAP
29	hematoxylin32	8.5	MYH11, ENO2, CDKN2A, S100B, S100A1, MUC1
30	adriamycin32	8.5	PRKCA, CDKN2A, CD36, MUC1, VIM
31	paclitaxel32 34 9 9	11.4	PRKCA, ESRRB, MAPT, CDKN2A, S100B, VIM
32	cysteine32	8.4	PRKCA, MAPT, CDKN2A, S100B, S100A1, MUC1
33	cytarabine32 34 9 9	11.4	CDKN2A, CDKN2B, CD36, MUC1, VIM
34	leucine32	8.3	TSN, ENO2, ASS1, CDKN2A, FUS, S100B
35	adenylate32	8.3	PRKCA, PLAGL1, ENO2, ASS1, S100B, MTAP
36	dopamine32 9 18 9	11.2	PRKCA, NR1H2, ESRRB, MAPT, ENO2, CDKN2A
37	testosterone32 9 18 9	11.1	PLAGL1, NR1H2, MAPT, ENO2, CDKN2A, S100B
38	agar32	8.1	VIM, MUC1, MTAP, CDKN2A, PRKCA
39	nitric oxide32 9 18 9	11.0	MYH11, ENO2, ASS1, CDKN2A, S100B, S100A1
40	progesterone32 42 9 18 9	12.0	MYH11, NR1H2, ESRRB, ENO2, CDKN2A, S100B
41	creatinine32	7.8	MAPT, ENO2, ASS1, CDKN2A, CD36, S100B
42	methotrexate32 34 42 9 9	11.7	NR1H2, ENO2, CDKN2A, CDKN2B, MTAP, MUC1
43	arginine32	7.7	PRKCA, NR1H2, EWSR1, MAPT, ASS1, CDKN2A
44	paraffin32	7.6	MYH11, EWSR1, MAPT, ENO2, CDKN2A, CD36
45	dexamethasone32 42 34 9 9	11.6	NR1H2, ESRRB, ENO2, ASS1, CDKN2A, CD36
46	vegf32	7.5	MYH11, PRKCA, NR1H2, ENO2, CDKN2A, CD36
47	tyrosine32	7.5	PRKCA, TFG, NR4A3, ESRRB, EWSR1, ENO2
48	alanine32	7.5	PRKCA, NR1H2, MAPT, ENO2, ASS1, CDKN2A
49	serine32	6.6	MYH11, PRKCA, NR1H2, EWSR1, MAPT, CDKN2A
50	retinoic acid32 42 18	8.0	MAPT, EWSR1, ESRRB, NR1H2, PRKCA, MYH11

Cellular components related to myxoid chondrosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:005654	7.5	FUS, PRKCA, SMARCB1, NR4A3, NR1H2, ESRRB
2	cytoplasm	GO:005737	5.9	TAF15, TFG, TSN, NR1H2, EWSR1, ASS1
3	nucleus	GO:005634	5.4	NR1H2, NR4A3, SMARCB1, PLAGL1, TSN, TAF15

Biological processes related to myxoid chondrosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	CDKN2B, CDKN2A, ESRRB, NR1H2, SMARCB1, PLAGL1

Molecular functions related to myxoid chondrosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	S100 protein binding	GO:044548	10.0	S100A1, S100B
2	lipoprotein particle binding	GO:071813	9.9	CD36, MAPT
3	steroid hormone receptor activity	GO:003707	9.7	NR4A3, NR1H2, ESRRB
4	p53 binding	GO:002039	9.1	MUC1, CDKN2A, SMARCB1
5	RNA binding	GO:003723	8.9	FUS, ISG20, EWSR1, TSN, TDRKH, TAF15
6	protein binding	GO:005515	5.3	EWSR1, NR1H2, SMARCB1, TSN, TFG, TAF15