MCID: MYX008
MIFTS: 31

Myxoid Chondrosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Myxoid Chondrosarcoma

Aliases & Descriptions for Myxoid Chondrosarcoma:

Name: Myxoid Chondrosarcoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5861
NCIt 47 C4303
SNOMED-CT 64 189881008 75622000
UMLS 69 C0334551

Summaries for Myxoid Chondrosarcoma

MalaCards based summary : Myxoid Chondrosarcoma is related to adult myxoid chondrosarcoma and pediatric myxoid chondrosarcoma. An important gene associated with Myxoid Chondrosarcoma is TAF15 (TATA-Box Binding Protein Associated Factor 15), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung.

Wikipedia : 71 Myxoid chondrosarcoma is a type of... more...

Related Diseases for Myxoid Chondrosarcoma

Diseases in the Myxoid Chondrosarcoma family:

Adult Myxoid Chondrosarcoma

Diseases related to Myxoid Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 adult myxoid chondrosarcoma 12.3
2 pediatric myxoid chondrosarcoma 12.0
3 chondrosarcoma, extraskeletal myxoid 11.9
4 extraosseous chondrosarcoma 11.0
5 chondrosarcoma 10.9
6 sarcoma 10.3
7 ovarian large-cell neuroendocrine carcinoma 10.2 EWSR1 TAF15
8 ampulla of vater mucinous adenocarcinoma 10.1 EWSR1 S100B
9 extranodal nasal nk/t cell lymphoma 10.1 CDKN2B EWSR1
10 lucey-driscoll syndrome 10.1 MUC1 S100B
11 secondary pulmonary hemosiderosis 10.1 MUC1 S100B
12 myelinoclastic diffuse sclerosis 10.1 MUC1 S100B
13 invasive mole 10.1 MUC1 S100B
14 myoma 10.1 MUC1 S100B
15 pemphigus vegetans 10.1 MUC1 S100B
16 spleen angiosarcoma 10.1 MUC1 S100B
17 ovarian cystadenoma 10.1 MUC1 S100B
18 cauda equina intradural extramedullary astrocytoma 10.1 EWSR1 MUC1
19 trombiculiasis 10.1 MUC1 S100B
20 biliary papillomatosis 10.1 MUC1 S100B
21 congenital muscular dystrophy with hyperlaxity 10.1 EWSR1 MUC1
22 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.1 MUC1 S100B
23 coronary restenosis 10.1 EWSR1 S100B
24 microinvasive cervical squamous cell carcinoma 10.1 MUC1 S100B
25 corneal intraepithelial neoplasm 10.1 MUC1 S100B
26 subglottis verrucous carcinoma 10.1 MUC1 S100B
27 porokeratosis 10.1 MUC1 S100B
28 conjunctival cancer 10.1 MUC1 S100B
29 clear cell ependymoma 10.1 MUC1 S100B
30 behcet's syndrome arthropathy 10.1 MUC1 S100B
31 sternum cancer 10.1 MUC1 S100B
32 kidney sarcoma 10.1 EWSR1 S100B
33 aneurysm of sinus of valsalva 10.1 MUC1 S100B
34 precursor t-lymphoblastic lymphoma/leukemia 10.1 MUC1 S100B
35 vulvar squamous papilloma 10.1 MUC1 S100B
36 mediastinum liposarcoma 10.1 MUC1 S100B
37 juvenile xanthogranuloma 10.1 EWSR1 S100B
38 colorectal cancer 1 10.1 EWSR1 NR4A3 TAF15
39 pulmonary neuroendocrine tumor 10.1 MUC1 S100B
40 uterine corpus leiomyomatosis 10.1 MUC1 S100B
41 gastrointestinal system cancer 10.0 MUC1 S100B
42 diarrhea, chronic, with villous atrophy 10.0 MUC1 S100B
43 childhood brain germinoma 10.0 MUC1 S100B
44 desmoid tumor 10.0 MUC1 S100B
45 monostotic fibrous dysplasia 10.0 MUC1 S100B
46 popliteal pterygium syndrome, bartsocas-papas type 10.0 MUC1 S100B
47 mongolian spot 10.0 MUC1 S100B
48 pathologic nystagmus 10.0 MUC1 S100B
49 central nervous system hemangioma 10.0 MUC1 S100B
50 chordoma 10.0

Graphical network of the top 20 diseases related to Myxoid Chondrosarcoma:



Diseases related to Myxoid Chondrosarcoma

Symptoms & Phenotypes for Myxoid Chondrosarcoma

Drugs & Therapeutics for Myxoid Chondrosarcoma

Drugs for Myxoid Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 1 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3,Phase 1 31703
6 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
7 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
8 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 1
9 Alkylating Agents Phase 2, Phase 3
10 Antineoplastic Agents, Alkylating Phase 2, Phase 3
11 Isophosphamide mustard Phase 2, Phase 3
12
Gemcitabine Approved Phase 2 95058-81-4 60750
13
Everolimus Approved Phase 2 159351-69-6 6442177
14
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
15
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
16 Antibodies Phase 2,Phase 1
17 Antibodies, Monoclonal Phase 2,Phase 1
18 Immunoglobulins Phase 2,Phase 1
19 insulin Phase 2
20 Insulin, Globin Zinc Phase 2
21 Mitogens Phase 2
22 Anti-Infective Agents Phase 2
23 Antimetabolites Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Antiviral Agents Phase 2
26 Immunosuppressive Agents Phase 2
27 Antifungal Agents Phase 2
28 Antirheumatic Agents Phase 2
29 lysine Nutraceutical Phase 2,Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
2 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2
3 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2
4 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Recruiting NCT02066285 Phase 2
6 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2
7 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
8 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2
9 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
10 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1

Search NIH Clinical Center for Myxoid Chondrosarcoma

Genetic Tests for Myxoid Chondrosarcoma

Anatomical Context for Myxoid Chondrosarcoma

MalaCards organs/tissues related to Myxoid Chondrosarcoma:

39
Bone, Breast, Lung, Heart, Thyroid, Skin, Pineal

Publications for Myxoid Chondrosarcoma

Articles related to Myxoid Chondrosarcoma:

(show top 50) (show all 232)
id Title Authors Year
1
Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast. ( 28402910 )
2017
2
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
3
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
4
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
5
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
6
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
7
Myxoid Chondrosarcoma of Maxilla in a Pediatric Patient: A Rare Case Report. ( 26904332 )
2016
8
Pulmonary extraskeletal myxoid chondrosarcoma: A case report and literature review. ( 27591381 )
2016
9
Myxoid chondrosarcoma of the mandible in a 22-year-old man: A case report. ( 27602220 )
2016
10
Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension. ( 27066425 )
2016
11
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. ( 27819877 )
2016
12
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. ( 27655120 )
2016
13
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity. ( 27194880 )
2016
14
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
15
Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature. ( 26504046 )
2015
16
Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. ( 26434451 )
2015
17
Unresectable Extraskeletal Myxoid Chondrosarcoma of the Neck: Early Tumor Response to Chemoradiotherapy. ( 26848421 )
2015
18
Extraskeletal myxoid chondrosarcoma of the vulva: A case report. ( 26622802 )
2015
19
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report. ( 26125202 )
2015
20
Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature. ( 26448808 )
2015
21
Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: report of a rare clinical presentation with an emphasis on differential diagnostic considerations. ( 25568751 )
2014
22
Activity of sunitinib in extraskeletal myxoid chondrosarcoma. ( 24703573 )
2014
23
Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report. ( 24818862 )
2014
24
Primary myxoid chondrosarcoma of the breast. ( 24417859 )
2014
25
Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. ( 24746215 )
2014
26
Extraskeletal myxoid chondrosarcoma: A report of two cases. ( 24944710 )
2014
27
Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. ( 25130955 )
2014
28
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. ( 24508382 )
2014
29
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases. ( 25177237 )
2014
30
Extraskeletal myxoid chondrosarcoma of the thigh in a child: a case report. ( 25550031 )
2014
31
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases. ( 24185117 )
2013
32
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study. ( 24345066 )
2013
33
Extraskeletal myxoid chondrosarcoma of the neck. ( 23230139 )
2013
34
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. ( 23588370 )
2013
35
The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC. ( 22581839 )
2012
36
Chromosomal translocation-negative cellular extraskeletal myxoid chondrosarcoma in an adolescent female. ( 22804337 )
2012
37
Extraskeletal myxoid chondrosarcoma of the left buccal mucosa. ( 22843913 )
2012
38
Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib. ( 23058004 )
2012
39
NR4A3 rearrangement reliably distinguishes between the clinicopathologically overlapping entities myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma. ( 22569967 )
2012
40
Spinal intradural myxoid chondrosarcoma. ( 22860877 )
2012
41
Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma. ( 22592656 )
2012
42
Extraskeletal myxoid chondrosarcoma with systemic metastasis in a five-month-old Irish setter dog. ( 22446404 )
2012
43
Intracranial extraskeletal myxoid chondrosarcoma : case report and literature review. ( 23115670 )
2012
44
Extraskeletal myxoid chondrosarcoma of the thigh with a t(9;17) translocation. ( 22740963 )
2012
45
Calcaneal myxoid chondrosarcoma: a rare case. ( 23591173 )
2012
46
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature. ( 23252871 )
2012
47
A novel sarcoma with dual differentiation: clinicopathologic and molecular characterization of a combined synovial sarcoma and extraskeletal myxoid chondrosarcoma. ( 22743288 )
2012
48
Primary intracranial extraskeletal myxoid chondrosarcoma. ( 22426765 )
2012
49
Myxoid chondrosarcoma of the cricoid cartilage. ( 23032857 )
2012
50
Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia. ( 22925697 )
2012

Variations for Myxoid Chondrosarcoma

Expression for Myxoid Chondrosarcoma

Search GEO for disease gene expression data for Myxoid Chondrosarcoma.

Pathways for Myxoid Chondrosarcoma

Pathways related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.05 EWSR1 NR4A3 TAF15

GO Terms for Myxoid Chondrosarcoma

Cellular components related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.17 CDKN2B EWSR1 MTAP MUC1 NR4A3 S100B

Molecular functions related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.92 EWSR1 NR4A3 S100B TAF15

Sources for Myxoid Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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