MCID: MYX008
MIFTS: 35

Myxoid Chondrosarcoma malady

Summaries for Myxoid Chondrosarcoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Myxoid chondrosarcoma is a type of sarcoma. more...

MalaCards: Myxoid Chondrosarcoma is related to extraskeletal myxoid chondrosarcoma and synovial sarcoma. An important gene associated with Myxoid Chondrosarcoma is TAF15 (TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa), and among its related pathways is Transcriptional misregulation in cancer. The compounds askin and nor 1 have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Myxoid Chondrosarcoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

myxoid chondrosarcoma 8 61


External Ids:

Disease Ontology8 DOID:5861
SNOMED-CT57 189881008, 75622000
NCIt40 C4303

Related Diseases for Myxoid Chondrosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myxoid Chondrosarcoma family:

adult myxoid chondrosarcoma

Diseases related to Myxoid Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1extraskeletal myxoid chondrosarcoma31.9NR4A3, TAF15, TFG
2synovial sarcoma30.2EWSR1
3myxoid liposarcoma30.2FUS, EWSR1
4intracranial chondrosarcoma10.5
5pediatric myxoid chondrosarcoma10.5
6adult myxoid chondrosarcoma10.5
7adult extraosseous chondrosarcoma10.2
8epithelial-myoepithelial carcinoma10.2
9myoepithelial carcinoma10.2
10extraskeletal mesenchymal chondrosarcoma10.2
11chondroid lipoma10.2
12soft tissue sarcoma10.2
13extraskeletal ewing sarcoma10.2
14glomus tumor10.0S100A1
15papilloma10.0NR1H2
16angiomyolipoma10.0S100A1
17thymic carcinoma10.0MUC1
18fibrosarcoma10.0CREB3L2
19retroperitoneal leiomyosarcoma10.0SMARCB1
20central nervous system cancer10.0ENO2
21amyotrophic lateral sclerosis10.0FUS, TAF15
22epulis10.0ENO2
23cerebral primitive neuroectodermal tumor10.0EWSR1, ENO2
24nephrogenic adenoma10.0S100A1
25langerhans-cell histiocytosis10.0S100B, S100A1
26desmoplastic small round cell tumor10.0EWSR1, MUC1
27rhabdoid tumor10.0SMARCB1, MUC1
28rosai-dorfman disease10.0S100B
29prostate cancer10.0NR1H2, ENO2
30ganglioglioma10.0S100B, ENO2
31fibrous meningioma10.0S100B, MUC1
32myoepithelioma10.0S100A1, S100B, EWSR1
33cutaneous fibrous histiocytoma10.0S100A1, S100B
34olfactory neuroblastoma10.0S100B, ENO2
35anaplastic ependymoma10.0S100B, MUC1
36choroid plexus papilloma10.0S100B, MUC1
37clear cell sarcoma10.0EWSR1, S100B, FUS
38spindle cell sarcoma10.0MUC1, S100B
39pleomorphic adenoma10.0PLAGL1
40chordoma10.0S100B, MUC1, S100A1
41dermatofibrosarcoma protuberans10.0S100B, MUC1, S100A1
42syringoma10.0MUC1, S100B, S100A1
43malignant peripheral nerve sheath tumor10.0S100B, MUC1, S100A1
44pineocytoma10.0ENO2, S100B
45fibrous histiocytoma10.0S100B, FUS
46malignant fibroxanthoma10.0S100A1, S100B, MUC1
47adenoid cystic carcinoma10.0MUC1, S100A1, S100B
48rhabdoid cancer10.0SMARCB1, ENO2
49neuroepithelioma10.0EWSR1, ENO2
50hemangiopericytoma10.0S100B, MUC1, S100A1

Graphical network of the top 20 diseases related to Myxoid Chondrosarcoma:



Diseases related to myxoid chondrosarcoma

Clinical Features for Myxoid Chondrosarcoma

Drugs & Therapeutics for Myxoid Chondrosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Myxoid Chondrosarcoma

Drug clinical trials:

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Genetic Tests for Myxoid Chondrosarcoma

Anatomical Context for Myxoid Chondrosarcoma

Animal Models for Myxoid Chondrosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Myxoid Chondrosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.1NR4A3, NR1H2, CHI3L1, TEC, TSN, FUS
2MP:00053848.4SMARCB1, EWSR1, NR4A3, NR1H2, CHI3L1, PLAGL1

Publications for Myxoid Chondrosarcoma

Sources:
51PubMed
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Articles related to Myxoid Chondrosarcoma:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. (23588370)
2013
2
A novel sarcoma with dual differentiation: clinicopathologic and molecular characterization of a combined synovial sarcoma and extraskeletal myxoid chondrosarcoma. (22743288)
2012
3
Calcaneal myxoid chondrosarcoma: a rare case. (23591173)
2012
4
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature. (23252871)
2012
5
Extraskeletal myxoid chondrosarcoma with small bowel metastasis causing bowel obstruction. (23213584)
2012
6
Primary intracranial extraskeletal myxoid chondrosarcoma. (22426765)
2012
7
Spinal intradural myxoid chondrosarcoma. (22860877)
2012
8
Extraskeletal myxoid chondrosarcoma with systemic metastasis in a five-month-old Irish setter dog. (22446404)
2012
9
Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib. (23058004)
2012
10
Intrathoracic rupture of an extraskeletal myxoid chondrosarcoma. (21547635)
2011
11
Extraskeletal myxoid chondrosarcoma of the nasopharynx. (21753718)
2011
12
Extraskeletal myxoid chondrosarcoma: a case report of complete remission by chemotherapy and review of the literature. (22315646)
2010
13
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. (18855877)
2009
14
Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy. (18568733)
2008
15
Skeletal recurrences and metastases of extraskeletal myxoid chondrosarcoma. (17437101)
2007
16
Cytopathology of extraskeletal myxoid chondrosarcoma: report of 8 cases. (17676582)
2007
17
An undifferentiated sarcoma in a rat resembling extraskeletal myxoid chondrosarcoma in man. (17676526)
2007
18
Extraskeletal myxoid chondrosarcoma arising from the clavicle. (16786132)
2006
19
Primary intradural myxoid chondrosarcoma: a case report and review in the literature. (16283441)
2005
20
Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: a case report. (15810095)
2005
21
Extraskeletal myxoid chondrosarcoma: updated clinicopathological and molecular genetic characteristics. (15998372)
2005
22
Extraskeletal myxoid chondrosarcoma of the jugular foramen. (15581026)
2004
23
Fine-needle aspiration cytology of intra-abdominal wall extraskeletal myxoid chondrosarcoma: a case report and review of the literature. (12946219)
2003
24
Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a case report with fine-needle aspiration biopsy, histopathology, electron microscopy, and cytogenetics. (14708728)
2003
25
Extraskeletal myxoid chondrosarcoma of the thoracic wall. (12866586)
2003
26
Extraskeletal myxoid chondrosarcoma of the chest wall masquerading as a breast tumor. A case report. (11917595)
2002
27
Intracranial extraskeletal myxoid chondrosarcoma: case report and review of the literature. (12181708)
2002
28
Heart metastasis of extraskeletal myxoid chondrosarcoma. (11259746)
2001
29
Phenotypic plasticity and prognostic factors in extraskeletal myxoid chondrosarcoma. (10721413)
2000
30
Metastases to the liver from extraskeletal myxoid chondrosarcoma and successful treatment with percutaneous ethanol injection. (10767194)
2000
31
Fine needle aspiration cytology of primary extraskeletal myxoid chondrosarcoma. A case report. (10834009)
2000
32
Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. (10602520)
1999
33
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors. (10439798)
1999
34
Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma. (9060841)
1997
35
Translocation (9;22)(q22;q12). A recurrent chromosome abnormality in extraskeletal myxoid chondrosarcoma. (7773957)
1995
36
The diagnosis of extraskeletal myxoid chondrosarcoma by fine needle aspiration. (8520007)
1995
37
Metastatic extraskeletal myxoid chondrosarcoma. Successful therapy with interferon alfa-2b. (7606973)
1995
38
Hu antigens and anti-Hu antibodies in a patient with myxoid chondrosarcoma. (8058170)
1994
39
Low-grade myxoid chondrosarcoma of the temporal bone: differential diagnosis and report of two cases. (8579153)
1994
40
Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma. (8214255)
1993
41
Unusual extraskeletal myxoid chondrosarcoma. (1373011)
1992
42
Extraskeletal myxoid chondrosarcoma of the epiglottis: case report and review of the literature. (1901157)
1991
43
Extraskeletal myxoid chondrosarcoma of the maxillary sinus. (1919329)
1991
44
Extraskeletal myxoid chondrosarcoma with intranuclear vacuoles and microtubular aggregates in the rough endoplasmic reticulum. Report of a case with fine needle aspiration and electron microscopy. (2256420)
1990
45
Extraskeletal myxoid chondrosarcoma of the head and neck: a case report. (2508028)
1989
46
Extraskeletal myxoid chondrosarcoma characterized by microtubular aggregates in the rough endoplasmic reticulum and tubulin immunoreactivity. (3193302)
1988
47
Microtubular aggregates within rough endoplasmic reticulum: an unusual ultrastructural feature of extraskeletal myxoid chondrosarcoma. (3699810)
1986
48
Myxoid chondrosarcoma with a translocation involving chromosomes 9 and 22. (3967207)
1985
49
Microtubular aggregates in the rough endoplasmic reticulum of a myxoid chondrosarcoma. (6927668)
1980
50
Extraskeletal myxoid chondrosarcoma. An analysis of 34 cases. (4261659)
1972

Genetic Variations for Myxoid Chondrosarcoma

Expression for genes affiliated with Myxoid Chondrosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxoid Chondrosarcoma

Search GEO for disease gene expression data for Myxoid Chondrosarcoma.

Pathways for genes affiliated with Myxoid Chondrosarcoma

Sources:
30KEGG
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Pathways related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FUS, TAF15, NR4A3, EWSR1

Compounds for genes affiliated with Myxoid Chondrosarcoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1askin4510.4ENO2, EWSR1
2nor 14510.4EWSR1, NR4A3
3edss4510.3ENO2, S100B
4eosin4510.3S100B, MUC1
5smcc4510.3ENO2, NR1H2
6mucicarmine4510.3S100B, S100A1, MUC1
7b 7234510.3S100A1, S100B, MUC1
8s 1004510.3S100B, MUC1, ENO2
9reticulin4510.2MUC1, S100B
10olopatadine45 1111.1S100B, S100A1
11hematoxylin4510.1S100A1, S100B, MUC1, ENO2
12formaldehyde45 2411.1ENO2, MUC1, NR1H2, S100B
13paraffin459.9S100B, S100A1, EWSR1, MUC1, ENO2
14zinc45 2410.8NR1H2, EWSR1, FUS, S100A1, PLAGL1, S100B
15toluidine459.8S100A1, ENO2
16progesterone45 60 29 11 2413.7ENO2, MUC1, S100A1, S100B, NR1H2
17retinoic acid45 2410.6MUC1, EWSR1, NR1H2, ENO2, S100A1, S100B
18testosterone45 60 11 2412.5S100B, MUC1, PLAGL1, ENO2, NR1H2
19tyrosine459.3TEC, ENO2, S100B, EWSR1, MUC1, NR4A3

GO Terms for genes affiliated with Myxoid Chondrosarcoma

Sources:
16Gene Ontology
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Cellular components related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.5SMARCB1, S100A1, EWSR1, CREB3L2, NR4A3, NR1H2

Molecular functions related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.8S100A1, S100B
2identical protein bindingGO:0428029.6FUS, TFG, EWSR1, S100A1, S100B
3sequence-specific DNA bindingGO:0435659.6NR1H2, NR4A3, CREB3L2, TSN, SIX3

Products for genes affiliated with Myxoid Chondrosarcoma

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Sources for Myxoid Chondrosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet