MCID: MYX008
MIFTS: 31

Myxoid Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Myxoid Chondrosarcoma

MalaCards integrated aliases for Myxoid Chondrosarcoma:

Name: Myxoid Chondrosarcoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5861
NCIt 46 C4303
SNOMED-CT 64 189881008 75622000
UMLS 69 C0334551

Summaries for Myxoid Chondrosarcoma

MalaCards based summary : Myxoid Chondrosarcoma is related to chondrosarcoma, extraskeletal myxoid and extraosseous chondrosarcoma. An important gene associated with Myxoid Chondrosarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung.

Wikipedia : 72 Myxoid chondrosarcoma is a type of... more...

Related Diseases for Myxoid Chondrosarcoma

Diseases in the Myxoid Chondrosarcoma family:

Adult Myxoid Chondrosarcoma

Diseases related to Myxoid Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma, extraskeletal myxoid 33.3 EWSR1 NR4A3 TAF15
2 extraosseous chondrosarcoma 32.0 EWSR1 TAF15
3 chondrosarcoma 30.5 EWSR1 MTAP NR4A3 TAF15
4 adult myxoid chondrosarcoma 12.4
5 pediatric myxoid chondrosarcoma 12.2
6 sarcoma 10.4
7 epithelial-myoepithelial carcinoma 10.2 NR4A3 TAF15
8 chordoma 10.1
9 ewing's family of tumors 10.1 CDKN2B EWSR1
10 skin sarcoma 10.1 CDKN2B EWSR1
11 ideomotor apraxia 10.0 EWSR1 MAPT
12 biphasic synovial sarcoma 10.0 EWSR1 MUC1
13 mesenchymal chondrosarcoma 10.0
14 thyroiditis 10.0
15 extraskeletal ewing sarcoma 10.0 EWSR1 MUC1
16 rhabdoid cancer 10.0 EWSR1 MUC1
17 desmoplastic small round cell tumor 9.9 EWSR1 MUC1
18 nervous system cancer 9.9 CDKN2B EWSR1
19 lipomatosis, multiple 9.9
20 sarcoma, synovial 9.9
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
22 chondroid lipoma 9.9
23 polyneuropathy 9.9
24 parachordoma 9.9
25 liposarcoma 9.9
26 encephalitis 9.9
27 fibromatosis 9.9
28 limbic encephalitis 9.9
29 soft tissue sarcoma 9.9
30 chondromyxoid fibroma 9.9
31 fibrous histiocytoma 9.8 EWSR1 MTAP
32 histiocytoma 9.8 EWSR1 MTAP
33 bone cancer 9.7 EWSR1 MTAP
34 cell type cancer 9.7 EWSR1 MUC1
35 amyotrophic lateral sclerosis 1 9.7 EWSR1 MAPT TAF15
36 ewing sarcoma 9.7 EWSR1 NR4A3 TAF15
37 precursor t-cell acute lymphoblastic leukemia 9.4 CDKN2B MTAP

Graphical network of the top 20 diseases related to Myxoid Chondrosarcoma:



Diseases related to Myxoid Chondrosarcoma

Symptoms & Phenotypes for Myxoid Chondrosarcoma

Drugs & Therapeutics for Myxoid Chondrosarcoma

Drugs for Myxoid Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 1 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3,Phase 1 31703
6 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 1
7 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
8 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
9 Isophosphamide mustard Phase 2, Phase 3 0
10 Alkylating Agents Phase 2, Phase 3
11
Gemcitabine Approved Phase 2 95058-81-4 60750
12 insulin Phase 2
13 Mitogens Phase 2
14 Antibodies, Monoclonal Phase 2,Phase 1
15 Immunoglobulins Phase 2,Phase 1
16 Insulin, Globin Zinc Phase 2
17 Antibodies Phase 2,Phase 1
18 Anti-Infective Agents Phase 2
19 Immunosuppressive Agents Phase 2
20 Antimetabolites Phase 2
21 Antimetabolites, Antineoplastic Phase 2
22 Antiviral Agents Phase 2
23 lysine Nutraceutical Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
3 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
4 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Recruiting NCT02066285 Phase 2 Pazopanib
6 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
7 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
8 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
9 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat

Search NIH Clinical Center for Myxoid Chondrosarcoma

Genetic Tests for Myxoid Chondrosarcoma

Anatomical Context for Myxoid Chondrosarcoma

MalaCards organs/tissues related to Myxoid Chondrosarcoma:

38
Bone, Breast, Lung, Cerebellum, Heart, Thyroid, Uterus

Publications for Myxoid Chondrosarcoma

Articles related to Myxoid Chondrosarcoma:

(show top 50) (show all 242)
# Title Authors Year
1
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
2
Anti-Hu-Associated Autoimmune Limbic Encephalitis in a Patient with PD-1 Inhibitor-Responsive Myxoid Chondrosarcoma. ( 29158368 )
2018
3
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. ( 29110880 )
2017
4
Curious case of extraskeletal myxoid chondrosarcoma. ( 28360467 )
2017
5
Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. ( 28249774 )
2017
6
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
7
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. ( 28187993 )
2017
8
Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast. ( 28402910 )
2017
9
Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient. ( 28638563 )
2017
10
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review: Erratum. ( 29390404 )
2017
11
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. ( 28383167 )
2017
12
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review. ( 29381948 )
2017
13
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
14
Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension. ( 27066425 )
2016
15
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. ( 27819877 )
2016
16
Myxoid chondrosarcoma of the mandible in a 22-year-old man: A case report. ( 27602220 )
2016
17
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
18
Pulmonary extraskeletal myxoid chondrosarcoma: A case report and literature review. ( 27591381 )
2016
19
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
20
Myxoid Chondrosarcoma of Maxilla in a Pediatric Patient: A Rare Case Report. ( 26904332 )
2016
21
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. ( 27655120 )
2016
22
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
23
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity. ( 27194880 )
2016
24
Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. ( 26434451 )
2015
25
Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature. ( 26504046 )
2015
26
Unresectable Extraskeletal Myxoid Chondrosarcoma of the Neck: Early Tumor Response to Chemoradiotherapy. ( 26848421 )
2015
27
Extraskeletal myxoid chondrosarcoma of the vulva: A case report. ( 26622802 )
2015
28
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report. ( 26125202 )
2015
29
Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature. ( 26448808 )
2015
30
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
31
Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. ( 25130955 )
2014
32
Activity of sunitinib in extraskeletal myxoid chondrosarcoma. ( 24703573 )
2014
33
Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report. ( 24818862 )
2014
34
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. ( 24508382 )
2014
35
Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: report of a rare clinical presentation with an emphasis on differential diagnostic considerations. ( 25568751 )
2014
36
Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. ( 24746215 )
2014
37
Primary myxoid chondrosarcoma of the breast. ( 24417859 )
2014
38
Extraskeletal myxoid chondrosarcoma of the thigh in a child: a case report. ( 25550031 )
2014
39
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases. ( 25177237 )
2014
40
Extraskeletal myxoid chondrosarcoma: A report of two cases. ( 24944710 )
2014
41
Extraskeletal myxoid chondrosarcoma of the neck. ( 23230139 )
2013
42
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study. ( 24345066 )
2013
43
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. ( 23588370 )
2013
44
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases. ( 24185117 )
2013
45
Calcaneal myxoid chondrosarcoma: a rare case. ( 23591173 )
2012
46
A novel sarcoma with dual differentiation: clinicopathologic and molecular characterization of a combined synovial sarcoma and extraskeletal myxoid chondrosarcoma. ( 22743288 )
2012
47
Myxoid chondrosarcoma of sphenoid bone. ( 23189013 )
2012
48
Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma. ( 22592656 )
2012
49
Primary intracranial extraskeletal myxoid chondrosarcoma. ( 22426765 )
2012
50
Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib. ( 23058004 )
2012

Variations for Myxoid Chondrosarcoma

Expression for Myxoid Chondrosarcoma

Search GEO for disease gene expression data for Myxoid Chondrosarcoma.

Pathways for Myxoid Chondrosarcoma

Pathways related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 EWSR1 NR4A3 TAF15

GO Terms for Myxoid Chondrosarcoma

Cellular components related to Myxoid Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.17 CDKN2B EWSR1 MAPT MTAP MUC1 NR4A3

Sources for Myxoid Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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