MCID: MYX008
MIFTS: 42

Myxoid Chondrosarcoma malady

Summaries for Myxoid Chondrosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Myxoid chondrosarcoma is a type of sarcoma. more...

MalaCards: Myxoid Chondrosarcoma is related to chondrosarcoma and extraskeletal myxoid chondrosarcoma. An important gene associated with Myxoid Chondrosarcoma is TAF15 (TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa), and among its related pathways is Transcriptional misregulation in cancer. The compounds askin and nor 1 have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Myxoid Chondrosarcoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

myxoid chondrosarcoma 8 60


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Disease Ontology8 DOID:5861
SNOMED-CT56 189881008, 75622000
NCIt39 C4303

Related Diseases for Myxoid Chondrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Myxoid Chondrosarcoma family:

Adult Myxoid Chondrosarcoma

Diseases related to Myxoid Chondrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.9FUS, S100B, S100A1, EWSR1, NR4A3, MUC1
2extraskeletal myxoid chondrosarcoma31.8TAF15, NR4A3, TFG
3sarcoma30.9S100B, S100A1, EWSR1, CREB3L2, NR4A3, MUC1
4chordoma30.5S100B, S100A1, MUC1
5synovial sarcoma30.2EWSR1
6myxoid liposarcoma30.1FUS, EWSR1
7lipoma30.1FUS, S100A1, C11orf95
8liposarcoma30.1C11orf95, EWSR1, TSN, FUS
9intracranial chondrosarcoma10.5
10pediatric myxoid chondrosarcoma10.4
11adult myxoid chondrosarcoma10.4
12extraosseous chondrosarcoma10.4
13mesenchymal chondrosarcoma10.3
14thyroiditis10.3
15adult extraosseous chondrosarcoma10.1
16epithelial-myoepithelial carcinoma10.1
17localized chondrosarcoma10.1
18extraskeletal mesenchymal chondrosarcoma10.1
19chondroid lipoma10.1
20chondroid chordoma10.1
21encephalomyelitis10.1
22parachordoma10.1
23polyneuropathy10.1
24glomus tumor10.0S100A1
25papilloma10.0NR1H2
26angiomyolipoma10.0S100A1
27thymus cancer10.0MUC1
28fibrosarcoma10.0CREB3L2
29retroperitoneal leiomyosarcoma10.0SMARCB1
30central nervous system cancer10.0ENO2
31amyotrophic lateral sclerosis10.0FUS, TAF15
32epulis10.0ENO2
33cerebral primitive neuroectodermal tumor10.0ENO2, EWSR1
34nephrogenic adenoma10.0S100A1
35langerhans-cell histiocytosis10.0S100B, S100A1
36desmoplastic small round cell tumor10.0EWSR1, MUC1
37rhabdoid tumor10.0SMARCB1, MUC1
38rosai-dorfman disease10.0S100B
39prostate cancer10.0NR1H2, ENO2
40ganglioglioma10.0ENO2, S100B
41fibrous meningioma10.0S100B, MUC1
42myoepithelioma10.0EWSR1, S100A1, S100B
43olfactory neuroblastoma10.0ENO2, S100B
44cutaneous fibrous histiocytoma10.0S100A1, S100B
45choroid plexus papilloma10.0S100B, MUC1
46anaplastic ependymoma10.0S100B, MUC1
47clear cell sarcoma10.0FUS, EWSR1, S100B
48spindle cell sarcoma10.0MUC1, S100B
49pleomorphic adenoma10.0PLAGL1
50dermatofibrosarcoma protuberans10.0MUC1, S100A1, S100B

Graphical network of the top 20 diseases related to Myxoid Chondrosarcoma:



Diseases related to myxoid chondrosarcoma

Clinical Features for Myxoid Chondrosarcoma

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Drugs & Therapeutics for Myxoid Chondrosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Myxoid Chondrosarcoma

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Anatomical Context for Myxoid Chondrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Myxoid Chondrosarcoma:

32
Bone, Breast, Lung, Thyroid, Heart, Bone marrow, Uterus, Liver, Pancreas, Pineal

Animal Models for Myxoid Chondrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxoid Chondrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.1NR4A3, NR1H2, CHI3L1, TEC, TSN, FUS
2MP:00053848.4SMARCB1, EWSR1, NR4A3, NR1H2, CHI3L1, PLAGL1

Publications for Myxoid Chondrosarcoma

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50PubMed
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Articles related to Myxoid Chondrosarcoma:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Extraskeletal myxoid chondrosarcoma of the neck. (23230139)
2013
2
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. (23588370)
2013
3
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases. (24185117)
2013
4
A novel sarcoma with dual differentiation: clinicopathologic and molecular characterization of a combined synovial sarcoma and extraskeletal myxoid chondrosarcoma. (22743288)
2012
5
Myxoid chondrosarcoma of the cricoid cartilage. (23032857)
2012
6
Chromosomal translocation-negative cellular extraskeletal myxoid chondrosarcoma in an adolescent female. (22804337)
2012
7
Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia. (22925697)
2012
8
The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC. (22581839)
2012
9
A case of highly aggressive extraskeletal myxoid chondrosarcoma. (21941486)
2011
10
Myxoid chondrosarcoma of the phalanx with an EWS translocation: a case report and review of the literature. (21411698)
2011
11
Myxoid chondrosarcoma of the scrotum: a case report and review of the literature. (20694088)
2010
12
Fluorescence in situ hybridization analysis of extraskeletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes. (19775727)
2010
13
Extraskeletal myxoid chondrosarcoma of the heart and review of current literature. (20975880)
2010
14
A case of myxoid chondrosarcoma arising from caput costae. (20380079)
2009
15
Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy. (18568733)
2008
16
Targeting the mammalian target of rapamycin in myxoid chondrosarcoma. (18827568)
2008
17
Retroperitoneal extraskeletal myxoid chondrosarcoma]. (17175793)
2006
18
Extraskeletal myxoid chondrosarcoma arising from the clavicle. (16786132)
2006
19
MRI features of extraskeletal myxoid chondrosarcoma. (16220270)
2006
20
Myxoid chondrosarcoma of the maxilla in a pediatric patient. (16007428)
2006
21
Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: a case report. (15810095)
2005
22
Extraskeletal myxoid chondrosarcoma: updated clinicopathological and molecular genetic characteristics. (15998372)
2005
23
Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype. (14657948)
2004
24
Extraskeletal myxoid chondrosarcoma as a second malignancy after bone marrow transplantation. (12652628)
2003
25
Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a case report with fine-needle aspiration biopsy, histopathology, electron microscopy, and cytogenetics. (14708728)
2003
26
Primary intracerebral myxoid chondrosarcoma. Case illustration. (12134922)
2002
27
Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. (12378528)
2002
28
Imaging of an exceptional tumor: myxoid chondrosarcoma of the jugular foramen. (12412972)
2001
29
Localization of (99m)Tc HMDP in an extraskeletal myxoid chondrosarcoma: a case report. (11376100)
2001
30
Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). (11156374)
2000
31
Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2). (10895826)
2000
32
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors. (10439798)
1999
33
Myxoid chondrosarcoma of the external auditory meatus. (10748851)
1999
34
Extraskeletal myxoid chondrosarcoma: a reappraisal of its morphologic spectrum and prognostic factors based on 117 cases. (10366145)
1999
35
Myxoid chondrosarcoma (chordoid sarcoma) of bone: a report of two cases and review of the literature. (9149016)
1997
36
Extraskeletal myxoid chondrosarcoma: a case report with fine needle aspiration (FNA) cytology. (9134340)
1997
37
Extraskeletal myxoid chondrosarcoma with dedifferentiation. (8847071)
1995
38
Radionuclide imaging in extraskeletal myxoid chondrosarcoma. (7648738)
1995
39
t(9;22)(q22-31;q11-12) is a consistent marker of extraskeletal myxoid chondrosarcoma: evaluation of three cases. (8539235)
1995
40
Low-grade myxoid chondrosarcoma of the temporal bone: differential diagnosis and report of two cases. (8579153)
1994
41
Intracranial extraskeletal myxoid chondrosarcoma with special reference to lamellar inclusions in the rough endoplasmic reticulum. (8310804)
1993
42
Low-grade myxoid chondrosarcoma of the base of the skull: CT, MR, and histopathology. (1545025)
1992
43
Extraskeletal myxoid chondrosarcoma with intranuclear vacuoles and microtubular aggregates in the rough endoplasmic reticulum. Report of a case with fine needle aspiration and electron microscopy. (2256420)
1990
44
Unusual extraskeletal myxoid chondrosarcoma in a child. (2323742)
1990
45
Nonrandom translocation in extraskeletal myxoid chondrosarcoma. (3567883)
1987
46
Intrapulmonary presentation of extraskeletal myxoid chondrosarcoma of the extremity. Report of two cases. (3731040)
1986
47
Case report 368: Enchondroma of the tibia with extensive myxoid degeneration; recurrence with secondary and malignant transformation to highly differentiated chondrosarcoma. (3726573)
1986
48
Myxoid chondrosarcoma with a translocation involving chromosomes 9 and 22. (3967207)
1985
49
Chordoid sarcoma (extraskeletal myxoid chondrosarcoma). (6402851)
1983
50
Extraskeletal myxoid chondrosarcoma. An analysis of 34 cases. (4261659)
1972

Genetic Variations for Myxoid Chondrosarcoma

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Expression for genes affiliated with Myxoid Chondrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxoid Chondrosarcoma

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Pathways for genes affiliated with Myxoid Chondrosarcoma

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29KEGG
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Pathways related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FUS, TAF15, NR4A3, EWSR1

Compounds for genes affiliated with Myxoid Chondrosarcoma

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1askin4410.4ENO2, EWSR1
2nor 14410.4EWSR1, NR4A3
3edss4410.3S100B, ENO2
4eosin4410.3MUC1, S100B
5smcc4410.3NR1H2, ENO2
6mucicarmine4410.3S100B, S100A1, MUC1
7b 7234410.3MUC1, S100A1, S100B
8s 1004410.3ENO2, MUC1, S100B
9reticulin4410.2MUC1, S100B
10olopatadine44 1111.1S100B, S100A1
11hematoxylin4410.1ENO2, MUC1, S100A1, S100B
12formaldehyde44 2411.1S100B, NR1H2, MUC1, ENO2
13paraffin449.9S100B, S100A1, EWSR1, MUC1, ENO2
14zinc44 2410.8S100B, S100A1, EWSR1, NR1H2, PLAGL1, FUS
15toluidine449.8ENO2, S100A1
16progesterone44 59 28 11 2413.7ENO2, MUC1, NR1H2, S100A1, S100B
17retinoic acid44 2410.6S100B, S100A1, EWSR1, NR1H2, MUC1, ENO2
18testosterone44 59 11 2412.5S100B, NR1H2, MUC1, PLAGL1, ENO2
19tyrosine449.3S100B, S100A1, EWSR1, TFG, NR4A3, MUC1

GO Terms for genes affiliated with Myxoid Chondrosarcoma

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16Gene Ontology
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Cellular components related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.5SMARCB1, S100A1, EWSR1, CREB3L2, NR4A3, NR1H2

Molecular functions related to Myxoid Chondrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.8S100B, S100A1
2identical protein bindingGO:0428029.6FUS, TFG, EWSR1, S100A1, S100B
3sequence-specific DNA bindingGO:0435659.6TSN, SIX3, NR1H2, NR4A3, CREB3L2

Products for genes affiliated with Myxoid Chondrosarcoma

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Sources for Myxoid Chondrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet