MCID: MYX006
MIFTS: 30

Myxoid Leiomyosarcoma malady

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Myxoid Leiomyosarcoma

Aliases & Descriptions for Myxoid Leiomyosarcoma:

Name: Myxoid Leiomyosarcoma 12 14
Leiomyosarcoma, Myxoid 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5268
MeSH 42 D007890
NCIt 47 C3701
SNOMED-CT 64 16090008 189792003
UMLS 69 C0205816

Summaries for Myxoid Leiomyosarcoma

MalaCards based summary : Myxoid Leiomyosarcoma, also known as leiomyosarcoma, myxoid, is related to uterine corpus myxoid leiomyosarcoma and leiomyosarcoma. An important gene associated with Myxoid Leiomyosarcoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Oocyte meiosis and Signaling events mediated by HDAC Class II. The drugs Trabectedin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and heart, and related phenotype is cardiovascular system.

Related Diseases for Myxoid Leiomyosarcoma

Graphical network of the top 20 diseases related to Myxoid Leiomyosarcoma:



Diseases related to Myxoid Leiomyosarcoma

Symptoms & Phenotypes for Myxoid Leiomyosarcoma

MGI Mouse Phenotypes related to Myxoid Leiomyosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 8.92 ACTC1 BCOR PGR YWHAE

Drugs & Therapeutics for Myxoid Leiomyosarcoma

Drugs for Myxoid Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 3,Phase 2 114899-77-3 108150
2
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 1 23214-92-8 31703
3
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
4
Epirubicin Approved Phase 3 56420-45-2 41867
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Gemcitabine Approved Phase 3,Phase 2 95058-81-4 60750
7
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
8
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
9
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
10
Doxil Approved June 1999 Phase 2, Phase 3,Phase 1 31703
11
Docetaxel Approved May 1996, Investigational Phase 3 114977-28-5 148124 9877265
12 Alkylating Agents Phase 3,Phase 2
13 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Alkylating Phase 3,Phase 2
16 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
17 Anti-Infective Agents Phase 3,Phase 2
18 Antimetabolites Phase 3,Phase 2
19 Antimetabolites, Antineoplastic Phase 3,Phase 2
20 Antimitotic Agents Phase 3
21 Antineoplastic Agents, Phytogenic Phase 3
22 Antiviral Agents Phase 3,Phase 2
23 Etoposide phosphate Phase 3
24 Immunosuppressive Agents Phase 3,Phase 2
25 Isophosphamide mustard Phase 3,Phase 2
26 Antibodies Phase 2,Phase 1
27 Antibodies, Monoclonal Phase 2,Phase 1
28 Immunoglobulins Phase 2,Phase 1
29
tremelimumab Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
3 Study of Doxorubicin and Trabectedin in First Line Treatment on Patients With Metastatic Leiomyosarcoma Completed NCT02131480 Phase 2
4 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
5 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
6 Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes Recruiting NCT02815995 Phase 2
7 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1

Search NIH Clinical Center for Myxoid Leiomyosarcoma

Genetic Tests for Myxoid Leiomyosarcoma

Anatomical Context for Myxoid Leiomyosarcoma

MalaCards organs/tissues related to Myxoid Leiomyosarcoma:

39
Uterus, Ovary, Heart, Liver, Cervix, Smooth Muscle, Kidney

Publications for Myxoid Leiomyosarcoma

Articles related to Myxoid Leiomyosarcoma:

(show top 50) (show all 57)
id Title Authors Year
1
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. ( 27717885 )
2017
2
Myxoid leiomyosarcoma of the cervix: A case report. ( 27937058 )
2016
3
Myxoid Leiomyosarcoma of the Uterus: A Clinicopathologic Analysis of 30 Cases and Review of the Literature With Reappraisal of Its Distinction From Other Uterine Myxoid Mesenchymal Neoplasms. ( 26866354 )
2016
4
Novel High-grade Endometrial Stromal Sarcoma: A Morphologic Mimicker of Myxoid Leiomyosarcoma. ( 27631520 )
2016
5
Myxoid leiomyosarcoma of the uterus with mature adipocytes and numerous bizarre multinucleated giant cells. ( 25583277 )
2015
6
Debulking surgery and hyperthermic intraperitoneal chemotherapy in the management of a recurrent aggressive uterine myxoid leiomyosarcoma with peritoneal dissemination. ( 26425725 )
2015
7
Uterine myxoid leiomyosarcoma with tumor embolism extending into the right atrium. ( 25722901 )
2015
8
Myxoid leiomyosarcoma of ovary-a rare case report. ( 25120990 )
2014
9
Myxoid leiomyosarcoma of the uterus: a case report. ( 24984552 )
2014
10
A rare case of uterine myxoid leiomyosarcoma: a case report. ( 25705290 )
2014
11
Myxoid leiomyosarcoma of the Bartholin gland. ( 25004325 )
2014
12
Uterine myxoid leiomyosarcoma with an underlying haematological disorder--case report and review of literature. ( 22669996 )
2011
13
Myxoid leiomyosarcoma of the uterus. ( 22175894 )
2011
14
Ocular myxoid leiomyosarcoma in a cat. ( 20149178 )
2010
15
Myxoid leiomyosarcoma of the uterus: a diagnostic challenge. ( 20882892 )
2010
16
Primary hepatic myxoid leiomyosarcoma: a case report and review of the literature. ( 18300035 )
2008
17
Primary intravascular myxoid leiomyosarcoma of the femoral vein presenting clinically as deep vein thrombosis: a case report. ( 17109153 )
2007
18
Myxoid leiomyosarcoma of the liver. ( 16316722 )
2006
19
Uterine myxoid leiomyosarcoma with widespread metastases in a cat. ( 16846999 )
2006
20
Myxoid leiomyosarcoma of the uterus in a patient receiving tamoxifen therapy: a case report. ( 16633068 )
2006
21
Massive myxoid leiomyosarcoma of the uterus. ( 15882188 )
2005
22
Myxoid leiomyosarcoma of the vulva. ( 15661250 )
2005
23
Disseminating myxoid leiomyosarcoma of the uterus. ( 14749942 )
2005
24
Primary myxoid leiomyosarcoma of the ovary. A case report with review of the literature. ( 16044903 )
2005
25
Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report. ( 14764049 )
2004
26
Myxoid leiomyosarcoma of the uterus with subsequent pregnancy and delivery. ( 12051888 )
2002
27
A case of primary myxoid leiomyosarcoma of the liver. ( 12647647 )
2002
28
Myxoid leiomyosarcoma of the gizzard in a broiler chicken. ( 11922347 )
2002
29
Peritoneal washing cytology findings of disseminated myxoid leiomyosarcoma of uterus: report of a case with emphasis on possible differential diagnosis. ( 12112816 )
2002
30
Myxoid leiomyosarcoma of the left atrium: a rare malignancy of the heart and its comparison with atrial myxoma. ( 11264566 )
2001
31
Myxoid leiomyosarcoma of the descending thoracic aorta. ( 11241099 )
2001
32
A huge abdominal mass mimicking ovarian cancer: p53-negative but aneuploid myxoid leiomyosarcoma of the uterus. ( 11728667 )
2001
33
Myxoid leiomyosarcoma of soft tissue, an underrecognized variant. ( 10895815 )
2000
34
Myxoid leiomyosarcoma of the uterus. Report of a case with cytologic findings. ( 10834002 )
2000
35
Myxoid leiomyosarcoma of the uterus. ( 11446377 )
2000
36
Uterine myxoid leiomyosarcoma within a leiomyoma. ( 10746687 )
2000
37
Uterine myxoid leiomyosarcoma. ( 10808004 )
2000
38
Myxoid leiomyosarcoma of the uterus: a case report. ( 10609511 )
1999
39
Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. ( 9811191 )
1998
40
Immunohistochemistry (Ki-67 and p53) as a tool in determining malignancy in smooth muscle neoplasms (exemplified by a myxoid leiomyosarcoma of the uterus). ( 8980620 )
1996
41
An unusual myxoid leiomyosarcoma of the heart. ( 8651863 )
1996
42
Myxoid leiomyosarcoma of the uterus with unusual malignant histologic pattern--a case report. ( 7557604 )
1995
43
Pulmonary myxoid leiomyosarcoma. ( 8581153 )
1995
44
Myxoid leiomyosarcoma of the uterine cervix. ( 7835845 )
1994
45
Uterine myxoid leiomyosarcoma and CYVADIC-etoposide therapy. ( 7806003 )
1994
46
Metastasis of a myxoid leiomyosarcoma via the renal and hepatic portal circulation in a sarus crane (Grus antigone). ( 8473559 )
1993
47
Myxoid leiomyosarcoma of the uterus. ( 8428703 )
1993
48
Myxoid leiomyosarcoma of the stomach: a case report. ( 1805049 )
1991
49
Myxoid leiomyosarcoma of the ovary: analysis of three cases. ( 1748433 )
1991
50
Myxoid leiomyosarcoma of the kidney accompanying ipsilateral ureteral transitional cell carcinoma. A case report with cytological, immunohistochemical and ultrastructural study. ( 1776470 )
1991

Variations for Myxoid Leiomyosarcoma

Expression for Myxoid Leiomyosarcoma

Search GEO for disease gene expression data for Myxoid Leiomyosarcoma.

Pathways for Myxoid Leiomyosarcoma

Pathways related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 PGR YWHAE
2 10.15 BCOR YWHAE

GO Terms for Myxoid Leiomyosarcoma

Molecular functions related to Myxoid Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 8.62 BCOR YWHAE

Sources for Myxoid Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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