MRCLS
MCID: MYX005
MIFTS: 56

Myxoid Liposarcoma (MRCLS) malady

Cancer category

Summaries for Myxoid Liposarcoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A myxoid liposarcoma is a malignant adipose tissue neoplasm. more...

MalaCards: Myxoid Liposarcoma, also known as myxoid/round cell liposarcoma, is related to pleomorphic adenoma and adenoma, and has symptoms including subcutaneous nodules/lipomas/tumefaction/swelling, soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma and acute abdominal pain/colic. An important gene associated with Myxoid Liposarcoma is DDIT3 (DNA-damage-inducible transcript 3), and among its related pathways are Adipogenesis and Rho Family GTPases. The compounds cycloheximide and amino acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spinal cord, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Description from OMIM:47 613488

Aliases & Classifications for Myxoid Liposarcoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 49Orphanet, 61UMLS, 45Novoseek, 35MeSH, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
liposarcoma:
Age of onset: Variable
myxoid/round cell liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

myxoid liposarcoma 8 9 43 47 10
myxoid/round cell liposarcoma 49 61
liposarcoma 49 61
liposarcoma, myxoid 61
liposarcoma myxoid 45
mrcls 49


External Ids:

Disease Ontology8 DOID:5363
MeSH35 D018208
NCIt40 C3735
OMIM47 613488
SNOMED-CT57 404069006, 27849002
ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet58 254829001, 49430005, 27849002 404069006, more
UMLS via Orphanet62 C0023827, C0206634
MESH via Orphanet36 D008080, D018208

Related Diseases for Myxoid Liposarcoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Myxoid Liposarcoma:



Diseases related to myxoid liposarcoma

Clinical Features for Myxoid Liposarcoma

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

613488

Symptoms:

49 (show all 6)
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • acute abdominal pain/colic
  • intestinal transit disorder
  • functional anomalies of the kidney and the urinary tract
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Myxoid Liposarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Myxoid Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Myxoid Liposarcoma

Search NIH Clinical Center for Myxoid Liposarcoma

Search CenterWatch for Myxoid Liposarcoma

Genetic Tests for Myxoid Liposarcoma

Anatomical Context for Myxoid Liposarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Myxoid Liposarcoma:

33
Bone marrow, Whole blood, Spinal cord, Heart, Small intestine, Adipocyte, Liver, Lung, Thyroid, Salivary gland, Breast, Ovary, Uterus, Testis, Myeloid, T cells, Tongue

Animal Models for Myxoid Liposarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Myxoid Liposarcoma

Sources:
51PubMed
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Articles related to Myxoid Liposarcoma:

(show top 50)    (show all 264)
idTitleAuthorsYear
1
Myxoid liposarcoma of the spermatic cord: US and MR imaging findings. (23861011)
2014
2
The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas. (22936067)
2013
3
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. (23918242)
2013
4
Myxoid liposarcoma in a 91-year-old patient. (24252207)
2013
5
Myxoid liposarcoma and the mammalian target of rapamycin pathway. (23673410)
2013
6
A case of myxoid liposarcoma of the breast. (23826427)
2013
7
Cardiac myxoid liposarcoma metastasis: cardiac magnetic resonance features. (22573904)
2012
8
Trabectedin as second-line treatment in metastatic myxoid liposarcoma: a case report. (23253485)
2012
9
Lipoblastoma mimicking myxoid liposarcoma: a clinical report and literature review. (21212605)
2011
10
Subcutaneous myxoid and round cell liposarcoma. (21909204)
2011
11
Prognostic factors and metastatic patterns in primary myxoid/round-cell liposarcoma. (22190864)
2011
12
Multi-level total en bloc spondylectomy for solitary lumbar metastasis of myxoid liposarcoma. (20806757)
2010
13
Primary myxoid liposarcoma of the ovary in an adolescent girl: a case report. (20407326)
2010
14
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option. (20863376)
2010
15
Breast carcinoma metastasis in recurrent myxoid liposarcoma. (18987996)
2009
16
Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays. (19368956)
2009
17
Myxoid liposarcoma. (17427222)
2007
18
FDG-PET Lacks Sufficient Sensitivity to Detect Myxoid Liposarcoma Spinal Metastases Detected by MRI. (17641744)
2007
19
A massive myxoid liposarcoma with hyperferritinemia. (18097123)
2007
20
Myxoid liposarcoma metastatic to the thyroid gland: a case report and literature review. (16563196)
2006
21
Isolated pancreatic metastasis of extremity myxoid liposarcoma: Report of a case. (16905757)
2006
22
Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis. (16177957)
2005
23
Low-grade pulmonary myxoid liposarcoma. (17670442)
2005
24
Metastatic myxoid liposarcoma: aggressive multimodality management. (15830582)
2005
25
Cardiac encasement by metastatic myxoid liposarcoma. (12459432)
2002
26
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells. (12168660)
2002
27
A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. (12169678)
2002
28
Myxoid liposarcoma in a 12-year-old girl: response. (11207984)
2001
29
A myxoid liposarcoma in the lower leg, with a large intra-abdominal metastasis. (11289594)
2001
30
Myxoid liposarcoma metastatic to the thoracic epidural space without bone involvement: report of two cases. (11689600)
2001
31
Treatment of myxoid liposarcoma in pregnancy. (10906875)
2000
32
Benign recurring lipoblastoma in an adult versus well differentiated subcutaneous myxoid liposarcoma: clinicopathologic, immunohistochemical and molecular analysis of a unique case. (10605700)
1999
33
Radiological findings in myxoid liposarcoma of the anterior mediastinum. (10195015)
1998
34
Stump the experts. Case. Myxoid liposarcoma. (9179244)
1997
35
Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation. (8976371)
1996
36
Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. (7805034)
1995
37
Cytogenetic and immunohistochemical profile of myxoid liposarcoma. (7817937)
1995
38
Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia. (21556567)
1995
39
Case report 851. Low-grade myxoid liposarcoma. (7939843)
1994
40
Isolation of a somatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line. (8428517)
1993
41
Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3. (8453640)
1993
42
Myxoid liposarcoma of the broad ligament. (11576262)
1992
43
General case of the day. Myxoid liposarcoma. (2028068)
1991
44
Myxoid liposarcoma of the buccal vestibule. A case report. (1761886)
1991
45
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
46
Retroperitoneal myxoid liposarcoma presenting with hypercalcaemia. (2703549)
1989
47
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
48
The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11). (3329717)
1987
49
Myxoid malignant fibrous histiocytoma versus myxoid liposarcoma. A comparative ultrastructural study. (6310855)
1983
50
Myxoid liposarcoma of the bladder. (6887379)
1983

Genetic Variations for Myxoid Liposarcoma

Expression for genes affiliated with Myxoid Liposarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxoid Liposarcoma

Search GEO for disease gene expression data for Myxoid Liposarcoma.

Pathways for genes affiliated with Myxoid Liposarcoma

Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG
See all sources

Pathways related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DDIT3, NR1H3, WNT1, CEBPB
2
Hide members
9.7CEBPB, WNT1, PGF, PRG4, DDIT3, PDGFA
39.7CEBPB, FUS, HMGA2, NFKBIZ, DDIT3, EWSR1

Compounds for genes affiliated with Myxoid Liposarcoma

Sources:
45Novoseek, 24HMDB
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Compounds related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4510.4PDGFA
2amino acid4510.1DDIT3, CEBPB
3actinomycin d4510.0DDIT3, POLR2L, HMGA2, PTX3, CEBPB
4vitamin d459.9CEBPB, POLR2L, NR1H3, PDGFA
5phosphatidylinositol459.8DDIT3, PGF, WNT1, CEBPB, PDGFA
6oligonucleotide459.8PDGFA, EWSR1, POLR2L, WNT1, TSN, CEBPB
7retinoic acid45 2410.7CEBPB, PDGFA, EWSR1, DDIT3, NR1H3, POLR2L
8paraffin459.7HMGA2, PGF, EWSR1, PDGFA
9tyrosine459.5PDGFA, EWSR1, DDIT3, PGF, WNT1, PTX3

GO Terms for genes affiliated with Myxoid Liposarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.0ADAD1, CREB3L3, DDIT3, NR1H3, NFKBIZ, POLR2L

Biological processes related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron differentiationGO:03018210.0CEBPB, WNT1, NNAT
2hematopoietic stem cell proliferationGO:07142510.0WNT1, PRG4
3regulation of transcription, DNA-dependentGO:0063559.7DDIT3, NFKBIZ, HMGA2, CEBPZ, CEBPB, EWSR1

Molecular functions related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.9CEBPB, TSN, NR1H3, DDIT3, CREB3L3
2DNA bindingGO:0036779.2CEBPB, DDIT3, NR1H3, POLR2L, HMGA2, TSN

Products for genes affiliated with Myxoid Liposarcoma

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Sources for Myxoid Liposarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet