MCID: MYX005
MIFTS: 40

Myxoid Liposarcoma malady

Rare diseases category

Summaries for Myxoid Liposarcoma

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OMIM:45 Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging... (613488) more...

MalaCards based summary: Myxoid Liposarcoma, also known as liposarcoma, myxoid, is related to liposarcoma and lipoma, and has symptoms including somatic mutationand myxoid liposarcoma. An important gene associated with Myxoid Liposarcoma is DDIT3 (DNA-damage-inducible transcript 3), and among its related pathways are Translational Control and Chromatin Regulation / Acetylation. The compound retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and liver, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:63 A myxoid liposarcoma is a malignant adipose tissue neoplasm. more...

Aliases & Classifications for Myxoid Liposarcoma

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Myxoid Liposarcoma, Aliases & Descriptions:

Name: Myxoid Liposarcoma 45 9 10 41 11
Liposarcoma, Myxoid 60
 
Liposarcoma Myxoid 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

OMIM45 613488
Disease Ontology9 DOID:5363
SNOMED-CT55 27849002, 404069006
NCIt38 C3735
MeSH33 D018208

Related Diseases for Myxoid Liposarcoma

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Graphical network of the top 20 diseases related to Myxoid Liposarcoma:



Diseases related to myxoid liposarcoma

Symptoms for Myxoid Liposarcoma

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Clinical features from OMIM:

613488

HPO human phenotypes related to Myxoid Liposarcoma:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 myxoid liposarcoma HP:0012268

Drugs & Therapeutics for Myxoid Liposarcoma

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Drug clinical trials:

Search ClinicalTrials for Myxoid Liposarcoma

Search NIH Clinical Center for Myxoid Liposarcoma

Genetic Tests for Myxoid Liposarcoma

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Anatomical Context for Myxoid Liposarcoma

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MalaCards organs/tissues related to Myxoid Liposarcoma:

31
Bone, Breast, Liver, Thyroid, Ovary, Myeloid, Bone marrow, Heart, Small intestine, Adipocyte, Lung, Salivary gland, Uterus, Testes, Tongue

Animal Models for Myxoid Liposarcoma or affiliated genes

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MGI Mouse Phenotypes related to Myxoid Liposarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.4HMGA2, NR1H3, EWSR1, FUS
2MP:00053798.1HMGA2, NR1H3, EWSR1, FUS, DDIT3
3MP:00053867.8HMGA2, NR1H3, WNT1, FUS, DDIT3
4MP:00053977.7DDIT3, FUS, EWSR1, WNT1, NR1H3
5MP:00053877.6DDIT3, FUS, EWSR1, WNT1, NR1H3
6MP:00053847.5NR1H3, WNT1, EWSR1, FUS, DDIT3
7MP:00036317.5DDIT3, FUS, WNT1, NR1H3, HMGA2

Publications for Myxoid Liposarcoma

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Articles related to Myxoid Liposarcoma:

(show top 50)    (show all 255)
idTitleAuthorsYear
1
Extensive lipoma-like changes of myxoid liposarcoma: morphologic, immunohistochemical, and molecular cytogenetic analyses. (25650275)
2015
2
Retroperitoneal perirenal myxoid liposarcoma. (25750026)
2015
3
Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways. (25562433)
2015
4
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
5
An extremely rare primary gallbladder myxoid liposarcoma associated with amplification of DDIT3 gene. (25532011)
2014
6
Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients. (23864817)
2013
7
The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens. (22261448)
2012
8
Recurrent myxoid liposarcoma of the buccal mucosa in a young boy: a case report and review of the literature. (22180120)
2011
9
Feasibility of whole-body MRI for detecting metastatic myxoid liposarcoma: a case series. (22049957)
2011
10
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
11
Limb salvage operation using intraoperative extracorporeal autogenous irradiated bone and tendon graft for myxoid liposarcoma on dorsum of foot. (20598521)
2010
12
A unique case of infraorbital myxoid liposarcoma. (20859874)
2010
13
Multi-level total en bloc spondylectomy for solitary lumbar metastasis of myxoid liposarcoma. (20806757)
2010
14
A giant primary myxoid liposarcoma of the posterior mediastinum. (20185322)
2010
15
Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. (19386100)
2009
16
Surgical treatment for epicardial metastasis of myxoid liposarcoma involving atrioventricular sulcus. (19583620)
2009
17
Multicentric myxoid liposarcoma: report of two cases. (18070341)
2007
18
Myxoid liposarcoma. (17427222)
2007
19
Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread. (17252290)
2007
20
Fine needle aspiration cytology in mediastinal myxoid liposarcoma: a case report. (17536554)
2007
21
Subacute complete ophthalmoplegia: an anti-Hu paraneoplastic manifestation of myxoid liposarcoma. (17651257)
2007
22
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
23
Metastatic myxoid liposarcoma in the mesentery: what is debated? Case report and a review of the literature. (16494187)
2006
24
Giant metastatic myxoid liposarcoma of the mediastinum: a case report. (15942593)
2005
25
Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas. (15201968)
2004
26
Neck metastasis of a myxoid liposarcoma of the lower extremity. (15571922)
2004
27
Metastatic patterns of extremity myxoid liposarcoma and their outcome. (12173385)
2002
28
Giant metastatic myxoid liposarcoma causing cardiac tamponade: a case report. (12499422)
2002
29
The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies. (11802205)
2002
30
Myxoid liposarcoma of the supraclavicular fossa. (10807849)
2000
31
A novel FUS/CHOP chimera in myxoid liposarcoma. (11162437)
2000
32
Pseudo-crossed renal ectopia secondary to a myxoid liposarcoma. (9836568)
1998
33
Myxoid liposarcoma. (7592290)
1995
34
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). (7566973)
1995
35
Myxoid liposarcoma. Experience with chemotherapy. (8055448)
1994
36
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (8510758)
1993
37
Isolation of a somatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line. (8428517)
1993
38
The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma. (7687873)
1993
39
Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). (1283316)
1992
40
Myxoid liposarcoma with t (12; 16)(q 13; p 11). Possible usefulness of chromosome analysis in a poorly differentiated sarcoma. (1437836)
1992
41
General case of the day. Myxoid liposarcoma. (2028068)
1991
42
Myxoid liposarcoma of the buccal vestibule. A case report. (1761886)
1991
43
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
44
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
45
The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11). (3329717)
1987
46
Cardiac metastases. Case report on an isolated cardiac metastasis of a myxoid liposarcoma. (3756779)
1986
47
Primary myxoid liposarcoma of the larynx. (6435071)
1984
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Benign lipoblastoma and myxoid liposarcoma: a comparative light- and electron-microscopic study. (7377463)
1980
50
Cardiac metastasis from myxoid liposarcoma emphasizing its radiosensitivity. (5692417)
1968

Variations for Myxoid Liposarcoma

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Expression for genes affiliated with Myxoid Liposarcoma

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Search GEO for disease gene expression data for Myxoid Liposarcoma.

Pathways for genes affiliated with Myxoid Liposarcoma

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Pathways related to Myxoid Liposarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0EWSR1, FUS, DDIT3
28.9HMGA2, EWSR1, FUS
38.8DDIT3, WNT1, NR1H3
48.5HMGA2, EWSR1, FUS, DDIT3

Compounds for genes affiliated with Myxoid Liposarcoma

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Sources:
43Novoseek, 24HMDB
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Compounds related to Myxoid Liposarcoma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1retinoic acid43 248.7HMGA2, NR1H3, WNT1, EWSR1, DDIT3

GO Terms for genes affiliated with Myxoid Liposarcoma

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Cellular components related to Myxoid Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.6HMGA2, NR1H3, FUS, DDIT3

Biological processes related to Myxoid Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Wnt signaling pathwayGO:00160559.3WNT1, DDIT3
2positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9HMGA2, WNT1
3positive regulation of transcription, DNA-templatedGO:00458938.3HMGA2, NR1H3, WNT1, DDIT3
4positive regulation of transcription from RNA polymerase II promoterGO:00459448.2DDIT3, WNT1, NR1H3, HMGA2

Molecular functions related to Myxoid Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA bindingGO:00036778.6HMGA2, NR1H3, FUS, DDIT3

Products for genes affiliated with Myxoid Liposarcoma

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Sources for Myxoid Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet