MRCLS
MCID: MYX005
MIFTS: 59

Myxoid Liposarcoma (MRCLS) malady

Rare diseases, Cancer diseases categories

Summaries for Myxoid Liposarcoma

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OMIM:46 Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging... (613488) more...

MalaCards based summary: Myxoid Liposarcoma, also known as myxoid/round cell liposarcoma, is related to liposarcoma and leiomyoma, and has symptoms including abnormality of the skin, sarcoma and abnormality of the skin. An important gene associated with Myxoid Liposarcoma is FUS (fused in sarcoma), and among its related pathways are Translational Control and Chromatin Regulation / Acetylation. The compounds actinomycin d and keratan sulfate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Wikipedia:64 A myxoid liposarcoma is a malignant adipose tissue neoplasm. more...

Aliases & Classifications for Myxoid Liposarcoma

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Sources:
9Disease Ontology, 10diseasecard, 42NIH Rare Diseases, 46OMIM, 11DISEASES, 48Orphanet, 61UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
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Myxoid Liposarcoma, Aliases & Descriptions:

Name: Myxoid Liposarcoma 9 10 42 46 11
Myxoid/round Cell Liposarcoma 48 61
Liposarcoma 48 61
 
Liposarcoma, Myxoid 61
Liposarcoma Myxoid 44
Mrcls 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
liposarcoma:
Age of onset: Variable
myxoid/round cell liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


External Ids:

Disease Ontology9 DOID:5363
NCIt39 C3735
OMIM46 613488
MeSH34 D018208
SNOMED-CT56 27849002, 404069006
MESH via Orphanet35 D008080, D018208
ICD10 via Orphanet27 C49
UMLS via Orphanet62 C0023827, C0206634

Related Diseases for Myxoid Liposarcoma

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Diseases related to Myxoid Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.6HMGA2, EWSR1, FUS, DES, DDIT3
2leiomyoma30.6HMGA2, DES
3clear cell sarcoma30.6EWSR1, FUS
4dedifferentiated liposarcoma30.6HMGA2, DES
5fibrous histiocytoma30.5DES, FUS
6pleomorphic adenoma30.5HMGA2, DES
7lipoma30.5DES, DDIT3, FUS, HMGA2
8leukemia30.4FUS, DDIT3, EWSR1, HMGA2
9rhabdomyosarcoma30.2DDIT3, EWSR1, DES
10desmoplastic small round cell tumor30.0EWSR1, DES
11synovial sarcoma30.0DES, HMGA2
12sarcoma30.0WNT1, EWSR1, DES, DDIT3, FUS, HMGA2
13breast cancer29.6WNT1, DDIT3, HMGA2
14chondrosarcoma29.3HMGA2, EWSR1, FUS, DES, DDIT3
15retroperitoneal liposarcoma11.0
16pleomorphic liposarcoma10.8
17myxoid liposarcoma of the ovary10.6
18atypical lipomatous tumor10.5
19spindle cell liposarcoma10.5
20cellular myxoid liposarcoma10.4
21lipoblastoma10.4
22inflammatory liposarcoma10.3
23liposarcoma of bone10.3
24acute myeloid leukemia10.3
25cardiac tamponade10.3
26adenoma10.3
27mediastinitis10.3
28myeloid leukemia10.3
29thyroiditis10.3
30myxofibrosarcoma10.3
31gastric liposarcoma10.3
32breast liposarcoma10.3
33kidney liposarcoma10.3
34larynx liposarcoma10.3
35mediastinum liposarcoma10.3
36mixed liposarcoma10.3
37fibrosarcoma10.3
38peripheral primitive neuroectodermal tumor10.2EWSR1, FUS
39sclerosing liposarcoma10.2
40esophagus liposarcoma10.2
41cutaneous liposarcoma10.2
42neurofibromatosis10.2
43mesenchymoma10.2
44osteosarcoma10.2
45smooth muscle tumor10.2HMGA2, DES
46acute leukemia10.2
47acute lymphoblastic leukemia10.2
48myelodysplastic syndromes10.2
49cutaneous leiomyosarcoma10.2
50appendicitis10.2

Graphical network of the top 20 diseases related to Myxoid Liposarcoma:



Diseases related to myxoid liposarcoma

Symptoms for Myxoid Liposarcoma

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Clinical features from OMIM:

613488

Symptoms:

 48
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • acute abdominal pain/colic
  • intestinal transit disorder
  • functional anomalies of the kidney and the urinary tract
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Myxoid Liposarcoma:

(show all 12)
id Description Frequency HPO Source Accession
1 abnormality of the skin hallmark (90%) HP:0000951
2 sarcoma hallmark (90%) HP:0100242
3 abnormality of the skin hallmark (90%) HP:0000951
4 sarcoma hallmark (90%) HP:0100242
5 abnormality of the urinary system occasional (7.5%) HP:0000079
6 abdominal pain occasional (7.5%) HP:0002027
7 abnormality of the intestine occasional (7.5%) HP:0002242
8 neoplasm of the lung occasional (7.5%) HP:0100526
9 abdominal pain occasional (7.5%) HP:0002027
10 abnormality of the intestine occasional (7.5%) HP:0002242
11 somatic mutation HP:0001428
12 myxoid liposarcoma HP:0012268

Drugs & Therapeutics for Myxoid Liposarcoma

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Drug clinical trials:

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Search NIH Clinical Center for Myxoid Liposarcoma

Genetic Tests for Myxoid Liposarcoma

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Anatomical Context for Myxoid Liposarcoma

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MalaCards organs/tissues related to Myxoid Liposarcoma:

32
Bone, Lung, Kidney, Breast, Liver, Thyroid, Myeloid, Bone marrow, Heart, Small intestine, Adipocyte, Salivary gland, Ovary, Uterus, Testes, Tongue

Animal Models for Myxoid Liposarcoma or affiliated genes

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MGI Mouse Phenotypes related to Myxoid Liposarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5FUS, EWSR1, NR1H3, HMGA2, DDIT3
2MP:00053698.4DES, NR1H3, WNT1, EWSR1
3MP:00053978.3NR1H3, DDIT3, WNT1, FUS, EWSR1
4MP:00036318.3FUS, WNT1, NR1H3, HMGA2, DDIT3
5MP:00053878.1DDIT3, WNT1, EWSR1, FUS, NR1H3
6MP:00053847.9EWSR1, NR1H3, WNT1, DDIT3, FUS
7MP:00107687.3DES, FUS, WNT1, PRG4, EWSR1, NR1H3
8MP:00053867.1DDIT3, DES, FUS, PRG4, WNT1, NR1H3

Publications for Myxoid Liposarcoma

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Articles related to Myxoid Liposarcoma:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
2
Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients. (23864817)
2013
3
Differentiation of myxoid liposarcoma by magnetic resonance imaging: a histopathologic correlation. (24123962)
2013
4
The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens. (22261448)
2012
5
Cardiac myxoid liposarcoma metastasis: cardiac magnetic resonance features. (22573904)
2012
6
Recurrent myxoid liposarcoma of the buccal mucosa in a young boy: a case report and review of the literature. (22180120)
2011
7
Feasibility of whole-body MRI for detecting metastatic myxoid liposarcoma: a case series. (22049957)
2011
8
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
9
Limb salvage operation using intraoperative extracorporeal autogenous irradiated bone and tendon graft for myxoid liposarcoma on dorsum of foot. (20598521)
2010
10
A unique case of infraorbital myxoid liposarcoma. (20859874)
2010
11
Multi-level total en bloc spondylectomy for solitary lumbar metastasis of myxoid liposarcoma. (20806757)
2010
12
A giant primary myxoid liposarcoma of the posterior mediastinum. (20185322)
2010
13
Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. (19386100)
2009
14
Surgical treatment for epicardial metastasis of myxoid liposarcoma involving atrioventricular sulcus. (19583620)
2009
15
Multicentric myxoid liposarcoma: report of two cases. (18070341)
2007
16
Myxoid liposarcoma. (17427222)
2007
17
Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread. (17252290)
2007
18
Fine needle aspiration cytology in mediastinal myxoid liposarcoma: a case report. (17536554)
2007
19
Subacute complete ophthalmoplegia: an anti-Hu paraneoplastic manifestation of myxoid liposarcoma. (17651257)
2007
20
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
21
Metastatic myxoid liposarcoma in the mesentery: what is debated? Case report and a review of the literature. (16494187)
2006
22
Giant metastatic myxoid liposarcoma of the mediastinum: a case report. (15942593)
2005
23
Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas. (15201968)
2004
24
Neck metastasis of a myxoid liposarcoma of the lower extremity. (15571922)
2004
25
Metastatic patterns of extremity myxoid liposarcoma and their outcome. (12173385)
2002
26
Giant metastatic myxoid liposarcoma causing cardiac tamponade: a case report. (12499422)
2002
27
The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies. (11802205)
2002
28
Myxoid liposarcoma of the supraclavicular fossa. (10807849)
2000
29
A novel FUS/CHOP chimera in myxoid liposarcoma. (11162437)
2000
30
Induction of a secreted protein by the myxoid liposarcoma oncogene. (10220412)
1999
31
Pseudo-crossed renal ectopia secondary to a myxoid liposarcoma. (9836568)
1998
32
Myxoid liposarcoma. (7592290)
1995
33
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). (7566973)
1995
34
Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. (7805034)
1995
35
Myxoid liposarcoma. Experience with chemotherapy. (8055448)
1994
36
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (8510758)
1993
37
Isolation of a somatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line. (8428517)
1993
38
The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma. (7687873)
1993
39
Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). (1283316)
1992
40
Myxoid liposarcoma with t (12; 16)(q 13; p 11). Possible usefulness of chromosome analysis in a poorly differentiated sarcoma. (1437836)
1992
41
General case of the day. Myxoid liposarcoma. (2028068)
1991
42
Myxoid liposarcoma of the buccal vestibule. A case report. (1761886)
1991
43
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
44
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
45
The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11). (3329717)
1987
46
Cardiac metastases. Case report on an isolated cardiac metastasis of a myxoid liposarcoma. (3756779)
1986
47
Primary myxoid liposarcoma of the larynx. (6435071)
1984
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Benign lipoblastoma and myxoid liposarcoma: a comparative light- and electron-microscopic study. (7377463)
1980
50
Cardiac metastasis from myxoid liposarcoma emphasizing its radiosensitivity. (5692417)
1968

Variations for Myxoid Liposarcoma

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Expression for genes affiliated with Myxoid Liposarcoma

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Expression patterns in normal tissues for genes affiliated with Myxoid Liposarcoma

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Pathways for genes affiliated with Myxoid Liposarcoma

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Pathways related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FUS, EWSR1, DDIT3
29.3FUS, EWSR1, HMGA2
39.0NR1H3, WNT1, DDIT3
48.9DDIT3, FUS, EWSR1, HMGA2
5
Show member pathways
8.3WNT1, PRG4, DDIT3, DES

Compounds for genes affiliated with Myxoid Liposarcoma

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Compounds related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1actinomycin d449.2DDIT3, DES, HMGA2
2keratan sulfate449.2PRG4, DES
3paraffin449.0HMGA2, EWSR1, DES
4iron44 259.9DDIT3, DES, LEPREL1
5cisplatin44 50 60 1211.9HMGA2, PRG4, DDIT3
6retinoic acid44 258.7HMGA2, NR1H3, WNT1, EWSR1, DES, DDIT3

GO Terms for genes affiliated with Myxoid Liposarcoma

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Cellular components related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.8HMGA2, NR1H3, FUS, DDIT3

Biological processes related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5HMGA2, WNT1
2hematopoietic stem cell proliferationGO:0714259.0WNT1, PRG4
3positive regulation of transcription, DNA-templatedGO:0458938.6HMGA2, NR1H3, WNT1, DDIT3
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.3DDIT3, WNT1, NR1H3, HMGA2

Molecular functions related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.9EWSR1, FUS, DES
2DNA bindingGO:0036778.8HMGA2, NR1H3, FUS, DDIT3

Products for genes affiliated with Myxoid Liposarcoma

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Sources for Myxoid Liposarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet