MRCLS
MCID: MYX005
MIFTS: 59

Myxoid Liposarcoma (MRCLS) malady

Cancer diseases category

Summaries for Myxoid Liposarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A myxoid liposarcoma is a malignant adipose tissue neoplasm. more...

MalaCards: Myxoid Liposarcoma, also known as myxoid/round cell liposarcoma, is related to liposarcoma and sarcoma, and has symptoms including subcutaneous nodules/lipomas/tumefaction/swelling, acute abdominal pain/colic and acute abdominal pain/colic. An important gene associated with Myxoid Liposarcoma is DDIT3 (DNA-damage-inducible transcript 3), and among its related pathways are Adipogenesis and Rho Family GTPases. The compounds cycloheximide and amino acid have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Description from OMIM:46 613488

Aliases & Classifications for Myxoid Liposarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 34MeSH, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
liposarcoma:
Age of onset: Variable
myxoid/round cell liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

myxoid liposarcoma 8 9 42 46 10
myxoid/round cell liposarcoma 48 60
liposarcoma 48 60
liposarcoma, myxoid 60
liposarcoma myxoid 44
mrcls 48


External Ids:

Disease Ontology8 DOID:5363
MeSH34 D018208
NCIt39 C3735
OMIM46 613488
SNOMED-CT56 404069006, 27849002
ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet57 254829001, 49430005, 404070007
UMLS via Orphanet61 C0023827, C0206634
MESH via Orphanet35 D008080, D018208

Related Diseases for Myxoid Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Myxoid Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.9FUS, TSN, HMGA2, DDIT3, EWSR1
2sarcoma30.6PDGFA, EWSR1, DDIT3, PGF, WNT1, HMGA2
3leukemia30.6EWSR1, DDIT3, POLR2L, PGF, HMGA2, FUS
4lipoma30.5DDIT3, HMGA2, FUS
5pleomorphic adenoma30.4HMGA2
6adenoma30.4HMGA2
7leiomyoma30.4HMGA2
8myeloid leukemia30.4CEBPB
9osteosarcoma30.2HMGA2, DDIT3, PDGFA
10fibrous histiocytoma30.1EWSR1, FUS
11rhabdomyosarcoma30.1DDIT3, EWSR1
12clear cell sarcoma30.1FUS, EWSR1
13retinoblastoma30.1PDGFA, POLR2L, CEBPB
14prostate cancer29.7DDIT3, POLR2L
15chondrosarcoma29.7FUS, HMGA2, DDIT3, EWSR1
16breast cancer29.7CEBPB, HMGA2, WNT1, PGF, POLR2L, DDIT3
17mediastinum liposarcoma10.5
18spindle cell liposarcoma10.5
19atypical lipomatous tumor10.4
20liposarcoma of bone10.4
21breast liposarcoma10.4
22myxoid liposarcoma of the ovary10.4
23acute leukemia10.4
24mixed-type liposarcoma10.4
25gastric liposarcoma10.3
26cardiac tamponade10.3
27acute myeloid leukemia10.3
28larynx liposarcoma10.3
29cellular myxoid liposarcoma10.3
30pleomorphic liposarcoma10.3
31mediastinitis10.3
32thyroiditis10.3
33sclerosing liposarcoma10.3
34retroperitoneal liposarcoma10.3
35kidney liposarcoma10.2
36fibroblastic liposarcoma10.2
37fibrosarcoma10.2
38neurofibromatosis10.2
39pediatric liposarcoma10.2
40mesenchymoma10.2
41clear cell adenoma10.1
42esophagus liposarcoma10.1
43adult liposarcoma10.1
44cutaneous liposarcoma10.1
45vulvar liposarcoma10.1
46inflammatory liposarcoma10.1
47appendicitis10.1
48cutaneous leiomyosarcoma10.1
49myxoid leiomyosarcoma10.1
50polycystic liver disease10.1

Graphical network of the top 20 diseases related to Myxoid Liposarcoma:



Diseases related to myxoid liposarcoma

Clinical Features for Myxoid Liposarcoma

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

613488

Symptoms:

48
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • acute abdominal pain/colic
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • intestinal transit disorder
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • functional anomalies of the kidney and the urinary tract

Drugs & Therapeutics for Myxoid Liposarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Myxoid Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Myxoid Liposarcoma

Search NIH Clinical Center for Myxoid Liposarcoma

Search CenterWatch for Myxoid Liposarcoma

Genetic Tests for Myxoid Liposarcoma

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Anatomical Context for Myxoid Liposarcoma

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32MalaCards
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MalaCards organs/tissues related to Myxoid Liposarcoma:

32
Bone, Lung, Kidney, Breast, Liver, Myeloid, Thyroid, Uterus, Bone marrow, Heart, Adipocyte, Testis, Small intestine, Tongue, Salivary gland, Ovary, Testes

Animal Models for Myxoid Liposarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxoid Liposarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.6CEBPB, EWSR1, DDIT3, NFKBIZ, HMGA2, PTX3
2MP:00053869.6PRG4, NR1H3, NFKBIZ, WNT1, HMGA2, TSN
3MP:00053759.5EWSR1, PGF, HMGA2, TSN, CEBPB
4MP:00053899.3PDGFA, EWSR1, NR1H3, HMGA2, PTX3, TSN
5MP:00053879.2EWSR1, CREB3L3, DDIT3, NR1H3, NFKBIZ, PGF

Publications for Myxoid Liposarcoma

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50PubMed
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Articles related to Myxoid Liposarcoma:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients. (23864817)
2013
2
Differentiation of myxoid liposarcoma by magnetic resonance imaging: a histopathologic correlation. (24123962)
2013
3
PPARI^ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma. (22293175)
2012
4
Primary dedifferentiated liposarcoma of the axilla arising in a mixed, well-differentiated and myxoid liposarcoma. (22690275)
2012
5
Myxoid/round cell liposarcoma of the supraclavicular fossa. (22359136)
2012
6
Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma. (22587772)
2012
7
Myxoid liposarcoma: a case report of a sentinel metastasis to the parotid gland with molecular confirmation. (22473934)
2011
8
Metastatic myxoid liposarcoma of lung and mediastinum diagnosed by fine needle aspiration. (21552406)
2011
9
A unique case of infraorbital myxoid liposarcoma. (20859874)
2010
10
Primary myxoid liposarcoma of the supraglottic larynx. (21139957)
2010
11
Functional mapping of receptor tyrosine kinases in myxoid liposarcoma. (20522586)
2010
12
Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay. (20581806)
2010
13
Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall. (20499293)
2010
14
Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop. (20515481)
2010
15
Multifocal myxoid liposarcoma--metastasis or second primary tumor?: a molecular biological analysis. (20093386)
2010
16
Imaging of skeletal metastases in myxoid liposarcoma. (20369068)
2010
17
Intradural involvement of multicentric myxoid liposarcoma. (21082059)
2010
18
Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. (19386100)
2009
19
Surgical treatment for epicardial metastasis of myxoid liposarcoma involving atrioventricular sulcus. (19583620)
2009
20
Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas. (19472403)
2009
21
Myxoid liposarcoma involving the liver, subcutaneous tissue, and epidural space in a polycystic disease patient. (18580245)
2008
22
Late widespread skeletal metastases from myxoid liposarcoma detected by MRI only. (18564429)
2008
23
Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread. (17252290)
2007
24
Fine needle aspiration cytology in mediastinal myxoid liposarcoma: a case report. (17536554)
2007
25
Spinal metastases from myxoid liposarcoma warrant screening with magnetic resonance imaging. (17724681)
2007
26
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
27
Cytogenetic analysis of myxoid liposarcoma and myxofibrosarcoma by array-based comparative genomic hybridisation. (16751306)
2006
28
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. (16651630)
2006
29
Giant metastatic myxoid liposarcoma of the mediastinum: a case report. (15942593)
2005
30
Solitary bone metastasis from myxoid liposarcoma. (12972699)
2003
31
Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma. (12890805)
2003
32
Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. (11751490)
2001
33
Vulval myxoid liposarcoma. (11520373)
2001
34
Myxoid liposarcoma of the oral cavity with involvement of the periodontal tissues. (11168734)
2001
35
Induction of a secreted protein by the myxoid liposarcoma oncogene. (10220412)
1999
36
A parapharyngeal myxoid liposarcoma. (10396576)
1999
37
Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas. (10449603)
1999
38
US case of the day. Myxoid liposarcoma of the spermatic cord. (9308118)
1997
39
Genomic PCR detects tumor cells in peripheral blood from patients with myxoid liposarcoma. (8913727)
1996
40
Rapid differential diagnosis of myxoid liposarcoma by fluorescence in situ hybridisation on cytological preparations. (16696094)
1996
41
Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. (7485386)
1995
42
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (8510758)
1993
43
Fine needle aspiration cytology of myxoid liposarcoma; a study of 18 tumours. (8485316)
1993
44
Limb-sparing treatment with surgery and intraoperative radiotherapy (IORT) for a second local recurrence of myxoid liposarcoma in the popliteal region, after previous surgery and high-dose radiation. (8479200)
1993
45
Myxoid liposarcoma with t (12; 16)(q 13; p 11). Possible usefulness of chromosome analysis in a poorly differentiated sarcoma. (1437836)
1992
46
Translocation t(12;16)(q13;p11) in myxoid liposarcoma of a child and implication of the human int-1 gene in tumorigenesis. (2515180)
1989
47
Cardiac metastasis from a myxoid liposarcoma. (3172814)
1988
48
A gigantic retroperitoneal myxoid liposarcoma. (7060610)
1982
49
Myxoid liposarcoma. An electronmicroscopic study: biological and histogenetic considerations. (159552)
1979
50
Embryonal liposarcoma (myxoid liposarcoma): a study of six cases. (5764284)
1969

Genetic Variations for Myxoid Liposarcoma

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Expression for genes affiliated with Myxoid Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxoid Liposarcoma

Search GEO for disease gene expression data for Myxoid Liposarcoma.

Pathways for genes affiliated with Myxoid Liposarcoma

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DDIT3, NR1H3, WNT1, CEBPB
2
Hide members
9.7CEBPB, WNT1, PGF, PRG4, DDIT3, PDGFA
39.7CEBPB, FUS, HMGA2, NFKBIZ, DDIT3, EWSR1

Compounds for genes affiliated with Myxoid Liposarcoma

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44Novoseek, 24HMDB
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Compounds related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4PDGFA
2amino acid4410.1DDIT3, CEBPB
3actinomycin d4410.0DDIT3, POLR2L, HMGA2, PTX3, CEBPB
4vitamin d449.9CEBPB, POLR2L, NR1H3, PDGFA
5phosphatidylinositol449.8DDIT3, PGF, WNT1, CEBPB, PDGFA
6oligonucleotide449.8PDGFA, EWSR1, POLR2L, WNT1, TSN, CEBPB
7retinoic acid44 2410.7CEBPB, PDGFA, EWSR1, DDIT3, NR1H3, POLR2L
8paraffin449.7HMGA2, PGF, EWSR1, PDGFA
9tyrosine449.5PDGFA, EWSR1, DDIT3, PGF, WNT1, PTX3

GO Terms for genes affiliated with Myxoid Liposarcoma

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16Gene Ontology
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Cellular components related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.0ADAD1, CREB3L3, DDIT3, NR1H3, NFKBIZ, POLR2L

Biological processes related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron differentiationGO:03018210.0CEBPB, WNT1, NNAT
2hematopoietic stem cell proliferationGO:07142510.0WNT1, PRG4
3regulation of transcription, DNA-dependentGO:0063559.7DDIT3, NFKBIZ, HMGA2, CEBPZ, CEBPB, EWSR1

Molecular functions related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.9CEBPB, TSN, NR1H3, DDIT3, CREB3L3
2DNA bindingGO:0036779.2CEBPB, DDIT3, NR1H3, POLR2L, HMGA2, TSN

Products for genes affiliated with Myxoid Liposarcoma

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Sources for Myxoid Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet