MRCLS
MCID: MYX005
MIFTS: 59

Myxoid Liposarcoma (MRCLS) malady

Cancer diseases category

Summaries for Myxoid Liposarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A myxoid liposarcoma is a malignant adipose tissue neoplasm. more...

MalaCards: Myxoid Liposarcoma, also known as myxoid/round cell liposarcoma, is related to liposarcoma and sarcoma, and has symptoms including soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma, acute abdominal pain/colic and intestinal transit disorder. An important gene associated with Myxoid Liposarcoma is DDIT3 (DNA-damage-inducible transcript 3), and among its related pathways are Adipogenesis and Rho Family GTPases. The compounds cycloheximide and amino acid have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Description from OMIM:46 613488

Aliases & Classifications for Myxoid Liposarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
liposarcoma:
Age of onset: Variable
myxoid/round cell liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

myxoid liposarcoma 8 9 42 46 10
myxoid/round cell liposarcoma 48 60
liposarcoma 48 60
liposarcoma, myxoid 60
liposarcoma myxoid 44
mrcls 48


External Ids:

Disease Ontology8 DOID:5363
MeSH34 D018208
NCIt39 C3735
OMIM46 613488
SNOMED-CT56 404069006, 27849002
ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet57 254829001, 49430005, 404070007
UMLS via Orphanet61 C0023827, C0206634
MESH via Orphanet35 D008080, D018208

Related Diseases for Myxoid Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Myxoid Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.9FUS, TSN, HMGA2, DDIT3, EWSR1
2sarcoma30.6PDGFA, EWSR1, DDIT3, PGF, WNT1, HMGA2
3leukemia30.6EWSR1, DDIT3, POLR2L, PGF, HMGA2, FUS
4lipoma30.5DDIT3, HMGA2, FUS
5pleomorphic adenoma30.4HMGA2
6adenoma30.4HMGA2
7leiomyoma30.4HMGA2
8myeloid leukemia30.4CEBPB
9osteosarcoma30.2HMGA2, DDIT3, PDGFA
10fibrous histiocytoma30.1EWSR1, FUS
11rhabdomyosarcoma30.1DDIT3, EWSR1
12clear cell sarcoma30.1FUS, EWSR1
13retinoblastoma30.1PDGFA, POLR2L, CEBPB
14prostate cancer29.7DDIT3, POLR2L
15chondrosarcoma29.7FUS, HMGA2, DDIT3, EWSR1
16breast cancer29.7CEBPB, HMGA2, WNT1, PGF, POLR2L, DDIT3
17mediastinum liposarcoma10.5
18spindle cell liposarcoma10.5
19atypical lipomatous tumor10.4
20liposarcoma of bone10.4
21breast liposarcoma10.4
22myxoid liposarcoma of the ovary10.4
23acute leukemia10.4
24mixed-type liposarcoma10.4
25gastric liposarcoma10.3
26cardiac tamponade10.3
27acute myeloid leukemia10.3
28larynx liposarcoma10.3
29cellular myxoid liposarcoma10.3
30pleomorphic liposarcoma10.3
31mediastinitis10.3
32thyroiditis10.3
33sclerosing liposarcoma10.3
34retroperitoneal liposarcoma10.3
35kidney liposarcoma10.2
36fibroblastic liposarcoma10.2
37fibrosarcoma10.2
38neurofibromatosis10.2
39pediatric liposarcoma10.2
40mesenchymoma10.2
41clear cell adenoma10.1
42esophagus liposarcoma10.1
43adult liposarcoma10.1
44cutaneous liposarcoma10.1
45vulvar liposarcoma10.1
46inflammatory liposarcoma10.1
47appendicitis10.1
48cutaneous leiomyosarcoma10.1
49myxoid leiomyosarcoma10.1
50polycystic liver disease10.1

Graphical network of the top 20 diseases related to Myxoid Liposarcoma:



Diseases related to myxoid liposarcoma

Clinical Features for Myxoid Liposarcoma

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46OMIM, 48Orphanet
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Clinical features from OMIM:

613488

Symptoms:

48
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • acute abdominal pain/colic
  • intestinal transit disorder
  • functional anomalies of the kidney and the urinary tract
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • subcutaneous nodules/lipomas/tumefaction/swelling

Drugs & Therapeutics for Myxoid Liposarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myxoid Liposarcoma

Search NIH Clinical Center for Myxoid Liposarcoma

Search CenterWatch for Myxoid Liposarcoma

Genetic Tests for Myxoid Liposarcoma

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Anatomical Context for Myxoid Liposarcoma

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32MalaCards
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MalaCards organs/tissues related to Myxoid Liposarcoma:

32
Bone, Lung, Kidney, Breast, Myeloid, Liver, Thyroid, Tongue, Salivary gland, Ovary, Uterus, Testis, Testes, Adipocyte, Small intestine, Heart, Bone marrow

Animal Models for Myxoid Liposarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxoid Liposarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.6CEBPB, EWSR1, DDIT3, NFKBIZ, HMGA2, PTX3
2MP:00053869.6PRG4, NR1H3, NFKBIZ, WNT1, HMGA2, TSN
3MP:00053759.5EWSR1, PGF, HMGA2, TSN, CEBPB
4MP:00053899.3PDGFA, EWSR1, NR1H3, HMGA2, PTX3, TSN
5MP:00053879.2EWSR1, CREB3L3, DDIT3, NR1H3, NFKBIZ, PGF

Publications for Myxoid Liposarcoma

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50PubMed
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Articles related to Myxoid Liposarcoma:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: report of a very rare case. (23276404)
2013
2
Myxoid liposarcoma and the mammalian target of rapamycin pathway. (23673410)
2013
3
Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. (23401071)
2013
4
The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens. (22261448)
2012
5
Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. (21642514)
2012
6
A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma. (22523595)
2012
7
Primary Pulmonary Myxoid Liposarcoma with Translocation t(12;16)(q13;p11) in a Young Female Patient: A Brief Case Report. (23110035)
2012
8
TLS-CHOP represses miR-486 expression, inducing upregulation of a metastasis regulator PAI-1 in human myxoid liposarcoma. (22995304)
2012
9
Trabectedin as second-line treatment in metastatic myxoid liposarcoma: a case report. (23253485)
2012
10
Feasibility of whole-body MRI for detecting metastatic myxoid liposarcoma: a case series. (22049957)
2011
11
Pericardial myxoid liposarcoma in a common eland (Taurotragus oryx). (21306730)
2011
12
Subcutaneous myxoid and round cell liposarcoma. (21909204)
2011
13
Prognostic factors and metastatic patterns in primary myxoid/round-cell liposarcoma. (22190864)
2011
14
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
15
Identification of genes over-expressed in myxoid/round cell liposarcoma. DNA microarray analysis and immunohistochemical correlation]. (19823827)
2010
16
Paratesticular myxoid liposarcoma in a 23-year old Nigerian. (21139825)
2010
17
Primary myxoid liposarcoma of the ovary in an adolescent girl: a case report. (20407326)
2010
18
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option. (20863376)
2010
19
Characteristic sequence motifs located at the genomic breakpoints of the translocation t(12;16) and t(12;22) in myxoid liposarcoma. (18752119)
2008
20
Isolated pancreatic metastasis of extremity myxoid liposarcoma: Report of a case. (16905757)
2006
21
Combined use of surgery and radiation in the treatment of an intradural myxoid liposarcoma in a dog. (16960043)
2006
22
Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. (15702084)
2005
23
Low-grade pulmonary myxoid liposarcoma. (17670442)
2005
24
Recurrent retroperitoneal myxoid liposarcoma during pregnancy: a case report and literature review. (16343222)
2005
25
Metastatic myxoid liposarcoma: aggressive multimodality management. (15830582)
2005
26
Pericardial metastasis of myxoid liposarcoma causing cardiac tamponade. (15875552)
2005
27
Radiation response: an additional unique signature of myxoid liposarcoma. (15380587)
2004
28
Myxoid liposarcoma of the spermatic cord: a case report and review of the literature. (15160541)
2003
29
Cardiac encasement by metastatic myxoid liposarcoma. (12459432)
2002
30
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells. (12168660)
2002
31
A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. (12169678)
2002
32
Re: Frequently recurring myxoid liposarcoma. (12389957)
2002
33
Myxoid liposarcoma metastatic to the thoracic epidural space without bone involvement: report of two cases. (11689600)
2001
34
A novel FUS/CHOP chimera in myxoid liposarcoma. (11162437)
2000
35
Treatment of myxoid liposarcoma in pregnancy. (10906875)
2000
36
The 16p11 breakpoint in myxoid liposarcomas might affect the expression of the LRP gene on 16p11.2 encoding the multidrug resistance associated major vault protein. (10809905)
2000
37
Fusion of the EWS and CHOP genes in myxoid liposarcoma. (8637704)
1996
38
Myxoid liposarcoma. (7592290)
1995
39
Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia. (21556567)
1995
40
Myxoid liposarcoma. Experience with chemotherapy. (8055448)
1994
41
A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12. (8076941)
1994
42
Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma. (8214255)
1993
43
Myxoid liposarcoma of the broad ligament. (11576262)
1992
44
Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12. (2253229)
1990
45
Myxoid liposarcoma: magnetic resonance imaging appearances with clinical and histological correlation. (2377902)
1990
46
A case of myxoid liposarcoma with translocation t(12;16) as the only abnormality. (3395985)
1988
47
Cardiac metastases. Case report on an isolated cardiac metastasis of a myxoid liposarcoma. (3756779)
1986
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Benign lipoblastoma and myxoid liposarcoma: a comparative light- and electron-microscopic study. (7377463)
1980
50
Cardiac metastasis from myxoid liposarcoma emphasizing its radiosensitivity. (5692417)
1968

Genetic Variations for Myxoid Liposarcoma

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Expression for genes affiliated with Myxoid Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxoid Liposarcoma

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Pathways for genes affiliated with Myxoid Liposarcoma

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DDIT3, NR1H3, WNT1, CEBPB
2
Hide members
9.7CEBPB, WNT1, PGF, PRG4, DDIT3, PDGFA
39.7CEBPB, FUS, HMGA2, NFKBIZ, DDIT3, EWSR1

Compounds for genes affiliated with Myxoid Liposarcoma

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44Novoseek, 24HMDB
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Compounds related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4PDGFA
2amino acid4410.1DDIT3, CEBPB
3actinomycin d4410.0DDIT3, POLR2L, HMGA2, PTX3, CEBPB
4vitamin d449.9CEBPB, POLR2L, NR1H3, PDGFA
5phosphatidylinositol449.8DDIT3, PGF, WNT1, CEBPB, PDGFA
6oligonucleotide449.8PDGFA, EWSR1, POLR2L, WNT1, TSN, CEBPB
7retinoic acid44 2410.7CEBPB, PDGFA, EWSR1, DDIT3, NR1H3, POLR2L
8paraffin449.7HMGA2, PGF, EWSR1, PDGFA
9tyrosine449.5PDGFA, EWSR1, DDIT3, PGF, WNT1, PTX3

GO Terms for genes affiliated with Myxoid Liposarcoma

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16Gene Ontology
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Cellular components related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.0ADAD1, CREB3L3, DDIT3, NR1H3, NFKBIZ, POLR2L

Biological processes related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron differentiationGO:03018210.0CEBPB, WNT1, NNAT
2hematopoietic stem cell proliferationGO:07142510.0WNT1, PRG4
3regulation of transcription, DNA-dependentGO:0063559.7DDIT3, NFKBIZ, HMGA2, CEBPZ, CEBPB, EWSR1

Molecular functions related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.9CEBPB, TSN, NR1H3, DDIT3, CREB3L3
2DNA bindingGO:0036779.2CEBPB, DDIT3, NR1H3, POLR2L, HMGA2, TSN

Products for genes affiliated with Myxoid Liposarcoma

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Sources for Myxoid Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet