Myxoid Liposarcoma malady

Wikipedia: A myxoid liposarcoma is a malignant adipose tissue neoplasm.⁴⁴ more...

MalaCards: Myxoid Liposarcoma, also known as myxoid liposarcoma (morphologic abnormality), is related to myxoid liposarcoma of the ovary and pleomorphic adenoma. An important gene associated with Myxoid Liposarcoma is DDIT3 (DNA-damage-inducible transcript 3), and among its related pathways are CREB Pathway and RAR-Gamma-RXR-Alpha Degradation. The compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include myeloid and t cells, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

OMIM: 613488

Aliases & Descriptions:

myxoid liposarcoma 6 7 30 8 33 myxoid liposarcoma (morphologic abnormality) 6 myxoid liposarcoma (disorder) 6

liposarcoma, myxoid 43 liposarcoma myxoid 32

Diseases related to myxoid liposarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 267)

id	Related Disease	Score	Top Affiliating Genes
1	myxoid liposarcoma of the ovary	31.6	ATF1, FUS, EWSR1, ERG, DDIT3, POLR2L
2	pleomorphic adenoma	30.0	HMGA2, DDIT3, PDGFA, DES, WNT1
3	lipoma	29.9	LRP1, FUS, HMGA2, DDIT3, DES
4	acute myeloid leukemia	25.9	VEGFA, MVP, CEBPZ, FUS, FLT1, IL6
5	myeloid leukemia	25.0	VEGFA, MVP, CEBPB, CEBPZ, ATF1, FUS
6	liposarcoma	24.8	LRP1, VEGFA, LEPREL1, MVP, YBX1, CEBPB
7	adenoma	23.5	VEGFA, FLT1, MIF, IL6, IL8, CCL2
8	sarcoma	21.5	VEGFA, MVP, YBX1, CEBPB, ATF1, FUS
9	leukemia	21.1	LRP1, VEGFA, MVP, YBX1, CEBPB, CEBPZ
10	kidney clear cell sarcoma	13.5	ATF1, FUS, EWSR1
11	myxoid chondrosarcoma	13.5	FUS, EWSR1, TSN
12	ring chromosomes	13.4	EWSR1, HMGA2, CREB3L2
13	fibrous histiocytoma	13.4	ATF1, FUS, DES
14	extraskeletal myxoid chondrosarcoma	13.3	FUS, EWSR1, CREB3L2, TSN, NPM3
15	desmoplastic small round cell tumor	13.2	EWSR1, PDGFA, DES
16	hemangioma of liver	13.2	VEGFA, DES
17	rheumatoid arthritis, systemic juvenile	13.1	MIF, IL6
18	bannayan-riley-ruvalcaba syndrome	13.1	MIF, HMGA2, PDGFA, DES
19	peripheral primitive neuroectodermal tumor	12.9	ATF1, FUS, EWSR1, ERG, DES
20	macular retinal edema	12.9	VEGFA, CXCL12
21	retinal hemangioblastoma	12.9	VEGFA, CXCL12
22	myoepithelioma	12.9	IL6, EWSR1, HMGA2, DES
23	benign tumors	12.8	MVP, FLT1, HMGA2, DES
24	chikungunya	12.8	MIF, IL6, POLR2A
25	systemic scleroderma	12.7	CEBPZ, MIF, CCL2, PDGFA, POLR2L
26	paraproteinemia	12.7	VEGFA, IL6
27	acute lymphoblastic leukemia	12.7	MVP, CEBPB, HMGA2, CXCL12, PGF
28	cerebral primitive neuroectodermal tumor	12.6	ATF1, EWSR1, ERG, SMARCA4, DES
29	nephroblastoma	12.6	MVP, FLT1, EWSR1, PDGFA, DES
30	neuroectodermal tumors	12.6	ATF1, EWSR1, ERG, SMARCA4, DES
31	critical limb ischemia	12.6	VEGFA, IL6, PGF
32	coronary arteriosclerosis	12.5	IL6, CCL2, CXCL12
33	synovial sarcoma	12.5	YBX1, IL6, EWSR1, HMGA2, TSN, DES
34	corneal neovascularization	12.5	VEGFA, FLT1, CXCL12
35	mesangial proliferative glomerulonephritis	12.5	VEGFA, IL6, CCL2
36	viral encephalitis	12.4	VEGFA, IL6, CCL2
37	kidney cancer	12.4	VEGFA, MIF, DES, CXCL12
38	central nervous system lymphoma	12.4	VEGFA, CCL2, PDGFA, CXCL12
39	diabetic macular edema	12.4	VEGFA, IL6, CCL2
40	hemangioendothelioma	12.4	VEGFA, FLT1, CCL2, PGF
41	pulmonary alveolar proteinosis	12.4	IL8, CCL2, NR1H3
42	proliferative glomerulonephritis	12.4	VEGFA, IL6, CCL2
43	cholesteatoma	12.3	VEGFA, MIF, IL6, PGF
44	chronic myeloproliferative disease	12.3	VEGFA, IL6, CXCL12
45	carpal tunnel syndrome	12.3	VEGFA, IL6, CCL2
46	usual interstitial pneumonia	12.3	IL8, CCL2, CXCL12
47	tonsillitis	12.3	VEGFA, LEPREL1, MIF, CCL2, DES
48	human t-cell leukemia virus type 1	12.2	ATF1, IL6, CREB3L3, CXCL12, POLR2L
49	acute pyelonephritis	12.2	LEPREL1, MIF, IL6, IL8
50	pericarditis	12.2	IL6, IL8, PRG4

Clinical features from OMIM: 613488

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to myxoid liposarcoma:

²²

MGI Mouse Phenotypes related to myxoid liposarcoma:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	FUS, EWSR1, HMGA2
2	respiratory system phenotype	MP:0005388	9.3	PGF, POLR2A, SMARCA4
3	integument phenotype	MP:0010771	9.3	POLR2A, NFKBIZ, SMARCA4, HMGA2, EWSR1, CEBPB
4	hematopoietic system phenotype	MP:0005397	9.1	WNT1, POLR2A, TSN, ERG, EWSR1, MIF
5	adipose tissue phenotype	MP:0005375	8.4	PGF, TSN, HMGA2, EWSR1, CCL2, IL6
6	liver/biliary system phenotype	MP:0005370	8.3	POLR2A, SMARCA4, NR1H3, IL6, YBX1, VEGFA
7	tumorigenesis	MP:0002006	7.8	PGF, POLR2A, SMARCA4, EWSR1, CCL2, IL6
8	skeleton phenotype	MP:0005390	7.7	WNT1, PRG4, PDGFA, CREB3L2, IL6, CEBPB
9	growth/size phenotype	MP:0005378	7.6	POLR2A, TSN, PDGFA, CREB3L2, ERG, HMGA2
10	reproductive system phenotype	MP:0005389	7.6	TSN, PDGFA, NR1H3, HMGA2, EWSR1, CCL2
11	behavior/neurological phenotype	MP:0005386	7.3	NFKBIZ, TSN, DES, PRG4, WNT1, NR1H3
12	normal phenotype	MP:0002873	7.2	EWSR1, NR1H3, CREB3L3, NNAT, POLR2A, MIF
13	immune system phenotype	MP:0005387	6.8	LRP1, PGF, POLR2A, TSN, NFKBIZ, CREB3L3
14	muscle phenotype	MP:0005369	6.6	NR1H3, SMARCA4, PDGFA, DES, WNT1, EWSR1
15	cardiovascular system phenotype	MP:0005385	6.0	PDGFA, DES, PRG4, CXCL12, PGF, SMARCA4
16	nervous system phenotype	MP:0003631	5.7	DDIT3, NR1H3, SMARCA4, PDGFA, CXCL12, WNT1
17	homeostasis/metabolism phenotype	MP:0005376	5.4	NR1H3, SMARCA4, CREB3L3, NFKBIZ, PDGFA, DES
18	cellular phenotype	MP:0005384	5.1	PTX3, DDIT3, NR1H3, SMARCA4, TSN, CXCL12
19	mortality/aging	MP:0010768	4.5	NR1H3, SMARCA4, CREB3L2, NFKBIZ, PDGFA, DES

Articles related to myxoid liposarcoma:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	Kinome profiling of myxoid liposarcoma reveals NF-kap paB-pathway kinase activity and casein kinase II inhibition as a potential trea tment option. (20863376)	Willems S.M.... BovAce J.V.	2010	FUS
2	Antitumor and anti-inflammatory effects of trabectedi n on human myxoid liposarcoma cells. (20215499)	Germano G.... Allavena P.	2010	VEGFA, CCL2, IL8
3	Nuclear expression of FLT1 and its ligand PGF in FUS- DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine sign aling loop. (20515481)	Andersson M.K.... Aman P.	2010	FLT1, PGF
4	Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. (19190116)	Forni C.... Mantovani R.	2009	FUS, EWSR1
5	The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ. (18850010)	GAPransson M.... Aman P.	2009	IL8, FUS, DDIT3
6	Characteristic sequence motifs located at the genomic breakpoints of the translocation t(12;16) and t(12;22) in myxoid liposarcoma. (18752119)	Xiang H.... Zhu X.	2008	FUS, TSN
7	Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion. (17647282)	Bode-Lesniewska B.... Zimmermann D.R.	2007	DDIT3, EWSR1
8	Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)	Riggi N.... Stamenkovic I.	2006	FUS, PDGFA
9	Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression. (15688424)	Goransson M.... Aman P.	2005	IL6, FUS, DDIT3
10	Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas. (15201968)	Panagopoulos I.... Mandahl N.	2004	FUS, PRG4
11	A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. (12169678)	Hosaka T.... Toguchida J.	2002	DDIT3, EWSR1
12	RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells. (12168660)	Rapp T.B.... Chansky H.A.	2002	POLR2A, FUS, DDIT3
13	Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. (10914725)	Antonescu C.R.... Ladanyi M.	2000	FUS, DDIT3
14	The 16p11 breakpoint in myxoid liposarcomas might affect the expression of the LRP gene on 16p11.2 encoding the multidrug resistance associated major vault protein. (10809905)	Plaat B.E.... van den Berg E.	2000	MVP
15	Myxoid liposarcoma with transition to round-cell lesion-cell cycle regulator genes and telomerase activity characterizing tumor progression: a case report. (10667432)	Jaeger V.... Roessner A.	1999	SMARCA4
16	Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas. (10449603)	Thelin-Jaernum S.... Aaman P.	1999	LEPREL1, NNAT
17	Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia. (9315104)	Panagopoulos I.... Aman P.	1997	DDIT3, EWSR1
18	Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features. (9306965)	Dal Cin P.... Fletcher C.D.	1997	EWSR1
19	Genomic PCR detects tumor cells in peripheral blood from patients with myxoid liposarcoma. (8913727)	Panagopoulos I.... Mitelman F.	1996	FUS
20	Fusion of the EWS and CHOP genes in myxoid liposarcoma. (8637704)	Panagopoulos I.... Aman P.	1996	FUS, DDIT3, EWSR1
21	Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). (7566973)	Panagopoulos I.... Aman P.	1995	FUS, DDIT3, ERG
22	Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. (7805034)	Knight J.C.... Fletcher C.D.	1995	FUS, DDIT3
23	Cytogenetic and immunohistochemical profile of myxoid liposarcoma. (7817937)	Gibas Z.... Debiec-Rychter M.	1995	DES
24	Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation. (7987849)	Panagopoulos I.... Aman P.	1994	FUS, DDIT3
25	Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (8510758)	Crozat A.... Ron D.	1993	FUS, DDIT3, NR1H3
26	The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma. (7687873)	Stenman G.... Aman P.	1993	DDIT3
27	Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). (1283316)	Aman P.... Mitelman F.	1992	DDIT3
28	Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14. (1318779)	Paulien S.... Gemmill R.M.	1992	LRP1
29	The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11). (3329717)	Turc-Carel C.... Sandberg A.A.	1987	WNT1

Genes related to myxoid liposarcoma according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	DDIT3	DNA-damage-inducible transcript 3	11.1	Summaries, Publications
2	FUS	fused in sarcoma	11.1	Publications, Functions, Aliases & Descriptions
3	LEPREL1	leprecan-like 1	11.1	Aliases & Descriptions, Publications
4	HMGA2	high mobility group AT-hook 2	11.0	Summaries
5	NNAT	neuronatin	11.0	Publications
6	NPM3	nucleophosmin/nucleoplasmin 3	11.0
7	PRG4	proteoglycan 4	11.0	Publications
8	TSN	translin	11.0	Publications
9	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	11.0	Publications
10	PTX3	pentraxin 3, long	11.0	Publications
11	CREB3L3	cAMP responsive element binding protein 3-like 3	11.0
12	WNT1	wingless-type MMTV integration site family, member 1	11.0	Publications
13	ADAD1	adenosine deaminase domain containing 1 (testis-specific)	11.0	Publications
14	CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta	11.0
15	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
16	NR1H3	nuclear receptor subfamily 1, group H, member 3	11.0	Publications
17	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
18	YBX1	Y box binding protein 1	11.0	Publications
19	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	11.0	Publications
20	PGF	placental growth factor	11.0	Publications
21	POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	11.0	Publications
22	MVP	major vault protein	11.0	Publications
23	ATF1	activating transcription factor 1	11.0
24	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
25	CREB3L2	cAMP responsive element binding protein 3-like 2	11.0
26	DES	desmin	11.0	Publications
27	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	11.0	Publications
28	POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	11.0	Publications
29	LRP1	low density lipoprotein receptor-related protein 1	11.0	Publications
30	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	11.0	Publications
31	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
32	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
33	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
34	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
35	VEGFA	vascular endothelial growth factor A	11.0	Publications
36	IL8	interleukin 8	11.0	Publications

Pathways related to myxoid liposarcoma according to GeneDecks:

(show top 50)    (show all 60)

id	Pathway	Score	Top Affiliating Genes
1	CREB Pathway36	10.3	POLR2A, PGF
2	RAR-Gamma-RXR-Alpha Degradation36	10.0	POLR2A, CXCL12
3	Actin-Based Motility by Rho Family GTPases36	10.0	PGF
4	PTEN Pathway36	9.9	PGF, PRG4, PDGFA, FLT1
5	Activation of Genes by ATF438	9.8	DDIT3, CCL2, IL8
6	Translational Control3	9.8	POLR2A, SMARCA4, DDIT3, FUS, YBX1
7	Pathways in cancer20	9.6	VEGFA, PDGFA, WNT1
8	ILK Signaling36	9.4	PGF, CXCL12, PRG4, PDGFA, ATF1, CEBPB
9	Immune response_MIF-mediated glucocorticoid regulation41	9.3	IL8, IL6, MIF
10	Immune response MIF-mediated glucocorticoid regulation10	9.3	IL8, IL6, MIF
11	Immune response_MIF in innate immunity response41	9.3	IL8, IL6, MIF, CEBPB
12	Immune response MIF in innate immunity response10	9.3	IL8, IL6, MIF, CEBPB
13	Molecular Mechanisms of Cancer36	9.3	WNT1, CXCL12, PRG4, PDGFA, IL6
14	JNK Pathway36	8.9	PGF, CXCL12, IL6, FLT1, CEBPB
15	Malaria20	8.9	LRP1, IL6, IL8, CCL2
16	Apoptotic Pathways in Synovial Fibroblasts36	8.9	PGF, CXCL12, PDGFA, IL6, FLT1
17	p53 Mediated Apoptosis36	8.9	FLT1, IL6, PDGFA, CXCL12, PGF
18	PPAR Pathway36	8.9	FLT1, IL6, CXCL12, PGF
19	Rac1 Pathway36	8.8	PGF, CXCL12, PDGFA, IL6
20	Mitochondrial Apoptosis36	8.8	PGF, CXCL12, PDGFA, IL6, FLT1
21	NF-KappaB (p50-p65) Pathway36	8.8	FLT1, IL6, PDGFA, CXCL12, PGF
22	Akt Signaling36	8.8	IL6, CCL2, PDGFA, CXCL12, PGF
23	DHA Signaling36	8.8	PGF, CXCL12, PDGFA, IL6, FLT1
24	Nanog in Mammalian ESC Pluripotency36	8.8	WNT1, PGF, CXCL12, PDGFA, IL6, FLT1
25	NF-KappaB Family Pathway36	8.7	PGF, CXCL12, PDGFA, IL6, FLT1
26	ERK5 Signaling36	8.7	FLT1, IL6, PDGFA, CXCL12, PGF
27	Cellular Apoptosis Pathway36	8.7	PGF, CXCL12, PDGFA, IL6, FLT1
28	GSK3 Signaling36	8.7	WNT1, PGF, CXCL12, PDGFA, IL6, FLT1
29	Telomerase Components in Cell Signaling36	8.6	PGF, POLR2A, CXCL12, PDGFA, IL6, FLT1
30	eIF2 Pathway36	8.6	PGF, CXCL12, PDGFA, IL6, FLT1
31	Nuclear Receptor Activation by Vitamin-A36	8.6	PGF, POLR2A, CXCL12, PDGFA, IL6, FLT1
32	p70S6K Signaling36	8.5	FLT1, IL6, PDGFA, CXCL12, PGF
33	Estrogen Pathway36	8.5	PGF, POLR2A, CXCL12, PDGFA, IL6, FLT1
34	MIF Mediated Glucocorticoid Regulation36	8.5	CXCL12, CCL2, IL8, IL6, MIF
35	MIF Regulation of Innate Immune Cells36	8.5	CXCL12, CCL2, IL8, IL6, MIF
36	Glucocorticoid Receptor Signaling36	8.5	POLR2A, SMARCA4, CCL2, IL8, IL6, CEBPB
37	Renin-Angiotensin Pathway36	8.4	PGF, CXCL12, PDGFA, CCL2, IL6, FLT1
38	MAPK Signaling36	8.3	PGF, CXCL12, PRG4, PDGFA, DDIT3, IL6
39	Activation of PKA through GPCR36	8.3	PGF, CXCL12, PDGFA, IL6, FLT1, ATF1
40	Tec Kinases Signaling36	8.0	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
41	TGF-Beta Pathway36	8.0	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
42	PAK Pathway36	8.0	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
43	MAPK Family Pathway36	8.0	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
44	JAK-STAT Pathway36	7.9	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
45	Antioxidant Action of Vitamin-C36	7.9	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
46	p38 Signaling36	7.9	PGF, CXCL12, PDGFA, DDIT3, CCL2, IL8
47	ERK Signaling36	7.6	PGF, CXCL12, PRG4, PDGFA, CCL2, IL8
48	Rho Family GTPases36	7.6	PGF, CXCL12, PRG4, DES, PDGFA, CCL2
49	Cytokine-cytokine receptor interaction20	7.4	CXCL12, PDGFA, CCL2, IL8, IL6, FLT1
50	Rheumatoid arthritis20	7.4	VEGFA, PGF, CXCL12, CCL2, IL8, IL6

Compounds related to myxoid liposarcoma according to GeneDecks:

(show top 50)    (show all 71)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.6	DDIT3, ATF1
2	endotoxin32	10.0	CEBPB, MIF
3	hyaluronic acid32 18	10.9	DES, PRG4, CXCL12
4	glucose32	9.8	PGF, DES, DDIT3, MIF, ATF1
5	lysine32	9.7	POLR2L, DES, SMARCA4, YBX1
6	oxygen32 18	10.6	PGF, PDGFA, DDIT3, MIF, FLT1
7	estrogen32	9.5	WNT1, DES, PDGFA, SMARCA4, MIF, YBX1
8	grobeta32	9.3	CXCL12, CCL2, IL8
9	tpck32	9.2	DDIT3, CCL2, IL8, IL6
10	mcp 132	9.2	IL6, IL8, CCL2
11	mip 1alpha32	9.1	CCL2, IL8, IL6
12	cyclic amp32 18	10.0	DES, PDGFA, CREB3L3, CREB3L2, SMARCA4, EWSR1
13	hcec32	8.9	CCL2, IL8, IL6
14	il-1232	8.9	IL6, IL8, CCL2
15	groalpha32	8.7	CXCL12, CCL2, IL8, IL6
16	oligonucleotide32	8.7	WNT1, POLR2L, TSN, PDGFA, SMARCA4, EWSR1
17	anaphylatoxin32	8.7	CXCL12, CCL2, IL8, IL6
18	tgf beta132	8.7	LRP1, FLT1, IL6, CCL2, PDGFA
19	vitamin d32	8.6	POLR2L, PDGFA, NR1H3, CCL2, IL6, CEBPB
20	ccl332	8.6	CXCL12, PTX3, CCL2, IL8, IL6
21	mg 13232 42	9.6	DDIT3, CCL2, IL8, CEBPB, VEGFA
22	paclitaxel32 34 9 9	11.6	DDIT3, MIF, FLT1, YBX1, MVP, VEGFA
23	atorvastatin32 34 9 18 9	12.5	PGF, NR1H3, CCL2, IL6, VEGFA
24	gm-csf32	8.4	CCL2, IL8, IL6, VEGFA
25	triptolide32	8.4	CCL2, IL8, IL6, VEGFA
26	doxorubicin32 34 9 9	11.4	POLR2L, DES, HMGA2, MIF, FLT1, YBX1
27	progesterone32 42 9 18 9	12.3	WNT1, CXCL12, DES, PDGFA, SMARCA4, FLT1
28	herbimycin a32 42	9.2	CXCL12, CCL2, IL8, IL6, MIF
29	rantes32	8.2	CXCL12, CCL2, IL8, IL6, MIF, CEBPB
30	cisplatin32 34 9 9	11.2	POLR2L, PRG4, DDIT3, HMGA2, CCL2, FLT1
31	phosphatidylinositol32	8.2	WNT1, PGF, CXCL12, PDGFA, DDIT3, CCL2
32	curcumin32	8.1	DDIT3, CCL2, IL8, IL6, MIF, VEGFA
33	retinoic acid32 42 18	10.1	WNT1, POLR2L, DES, PDGFA, NR1H3, DDIT3
34	n acetylcysteine32	8.0	VEGFA, CEBPB, IL6, IL8, CCL2, DDIT3
35	15-deoxy-delta-12,14-prostaglandin j232	8.0	CCL2, IL8, IL6, VEGFA
36	matrigel32	7.9	PGF, CXCL12, IL8, FLT1, VEGFA, LRP1
37	pd 98,05932	7.9	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
38	creatinine32	7.8	PGF, DES, PTX3, CCL2, IL6, MIF
39	paraffin32	7.8	HMGA2, PDGFA, DES, PGF, EWSR1, CCL2
40	heparin32 9 18 9	10.5	PGF, CXCL12, DES, PDGFA, IL8, FLT1
41	nitric oxide32 9 18 9	10.3	PGF, DES, DDIT3, PTX3, CCL2, IL8
42	cycloheximide32	7.2	PTX3, DDIT3, PDGFA, CXCL12, CCL2, IL8
43	lipid32	7.1	PGF, CXCL12, SMARCA4, NR1H3, CCL2, IL6
44	genistein32 9 18 9	10.0	CXCL12, DDIT3, CCL2, IL8, IL6, MIF
45	sb 20358032 42	8.0	CXCL12, DDIT3, CCL2, IL8, IL6, MIF
46	serine32	6.9	CXCL12, POLR2L, DES, EWSR1, LRP1, YBX1
47	actinomycin d32	6.9	POLR2L, CXCL12, DES, DDIT3, PTX3, HMGA2
48	dexamethasone32 42 34 9 9	10.6	POLR2L, CXCL12, PDGFA, PTX3, CCL2, IL8
49	vegf32	5.5	LRP1, PGF, POLR2L, CXCL12, DES, PDGFA
50	tyrosine32	5.4	DDIT3, SMARCA4, PDGFA, DES, CXCL12, PGF

Cellular components related to myxoid liposarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	6.4	PGF, CXCL12, PDGFA, CCL2, IL8, IL6
2	extracellular region	GO:005576	6.1	PGF, CXCL12, PRG4, PDGFA, PTX3, CCL2
3	nucleus	GO:005634	INF	LRP1, SMARCA4, CREB3L2, CREB3L3, NFKBIZ,
4	cytoplasm	GO:005737	INF	EWSR1, ERG, DDIT3, NR1H3, NNAT,

Biological processes related to myxoid liposarcoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of fibroblast proliferation	GO:048146	9.8	WNT1, PDGFA, MIF
2	regulation of vascular endothelial growth factor production	GO:010574	9.5	IL6, CCL2
3	positive regulation of cell division	GO:051781	9.3	VEGFA, YBX1, PDGFA, PGF
4	monocyte chemotaxis	GO:002548	9.2	CCL2, IL6, FLT1
5	vascular endothelial growth factor receptor signaling pathway	GO:048010	8.9	VEGFA, FLT1, CCL2, PGF
6	induction of positive chemotaxis	GO:050930	8.8	CXCL12, IL8, VEGFA
7	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.8	VEGFA, MIF, IL6
8	positive regulation of MAP kinase activity	GO:043406	8.8	PDGFA, FLT1, VEGFA
9	positive regulation of endothelial cell proliferation	GO:001938	8.7	PGF, CXCL12, CCL2, VEGFA
10	inflammatory response	GO:006954	8.4	NFKBIZ, PTX3, CCL2, IL8, IL6, MIF
11	angiogenesis	GO:001525	8.4	PGF, PDGFA, CCL2, IL8, VEGFA
12	response to hypoxia	GO:001666	8.2	PGF, CXCL12, CCL2, FLT1, VEGFA
13	negative regulation of apoptotic process	GO:043066	8.2	WNT1, CXCL12, HMGA2, IL6, MIF, VEGFA
14	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	WNT1, SMARCA4, NR1H3, DDIT3, HMGA2, IL6
15	positive regulation of cell proliferation	GO:008284	8.1	WNT1, PGF, PDGFA, IL6, FLT1, VEGFA

Molecular functions related to myxoid liposarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface binding	GO:043498	9.3	PDGFA, MIF, VEGFA
2	sequence-specific DNA binding	GO:043565	8.9	CEBPB, ATF1, ERG, DDIT3, NR1H3, CREB3L2
3	protein heterodimerization activity	GO:046982	8.5	PGF, PDGFA, NR1H3, ATF1, CEBPB, VEGFA
4	DNA binding	GO:003677	8.3	POLR2A, TSN, NR1H3, DDIT3, ERG, HMGA2
5	growth factor activity	GO:008083	7.8	PGF, CXCL12, PDGFA, IL6, VEGFA
6	protein binding	GO:005515	5.1	ERG, NR1H3, SMARCA4, CREB3L3, TSN, DES