MRCLS
MCID: MYX005
MIFTS: 59

Myxoid Liposarcoma (MRCLS) malady

Cancer diseases category

Summaries for Myxoid Liposarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A myxoid liposarcoma is a malignant adipose tissue neoplasm. more...

MalaCards: Myxoid Liposarcoma, also known as myxoid/round cell liposarcoma, is related to liposarcoma and sarcoma, and has symptoms including soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma, acute abdominal pain/colic and intestinal transit disorder. An important gene associated with Myxoid Liposarcoma is DDIT3 (DNA-damage-inducible transcript 3), and among its related pathways are Adipogenesis and Rho Family GTPases. The compounds cycloheximide and amino acid have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Description from OMIM:46 613488

Aliases & Classifications for Myxoid Liposarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
liposarcoma:
Age of onset: Variable
myxoid/round cell liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

myxoid liposarcoma 8 9 42 46 10
myxoid/round cell liposarcoma 48 60
liposarcoma 48 60
liposarcoma, myxoid 60
liposarcoma myxoid 44
mrcls 48


External Ids:

Disease Ontology8 DOID:5363
MeSH34 D018208
NCIt39 C3735
OMIM46 613488
SNOMED-CT56 404069006, 27849002
ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet57 254829001, 49430005, 404070007
UMLS via Orphanet61 C0023827, C0206634
MESH via Orphanet35 D008080, D018208

Related Diseases for Myxoid Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Myxoid Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.9FUS, TSN, HMGA2, DDIT3, EWSR1
2sarcoma30.6PDGFA, EWSR1, DDIT3, PGF, WNT1, HMGA2
3leukemia30.6EWSR1, DDIT3, POLR2L, PGF, HMGA2, FUS
4lipoma30.5DDIT3, HMGA2, FUS
5pleomorphic adenoma30.4HMGA2
6adenoma30.4HMGA2
7leiomyoma30.4HMGA2
8myeloid leukemia30.4CEBPB
9osteosarcoma30.2HMGA2, DDIT3, PDGFA
10fibrous histiocytoma30.1EWSR1, FUS
11rhabdomyosarcoma30.1DDIT3, EWSR1
12clear cell sarcoma30.1FUS, EWSR1
13retinoblastoma30.1PDGFA, POLR2L, CEBPB
14prostate cancer29.7DDIT3, POLR2L
15chondrosarcoma29.7FUS, HMGA2, DDIT3, EWSR1
16breast cancer29.7CEBPB, HMGA2, WNT1, PGF, POLR2L, DDIT3
17mediastinum liposarcoma10.5
18spindle cell liposarcoma10.5
19atypical lipomatous tumor10.4
20liposarcoma of bone10.4
21breast liposarcoma10.4
22myxoid liposarcoma of the ovary10.4
23acute leukemia10.4
24mixed-type liposarcoma10.4
25gastric liposarcoma10.3
26cardiac tamponade10.3
27acute myeloid leukemia10.3
28larynx liposarcoma10.3
29cellular myxoid liposarcoma10.3
30pleomorphic liposarcoma10.3
31mediastinitis10.3
32thyroiditis10.3
33sclerosing liposarcoma10.3
34retroperitoneal liposarcoma10.3
35kidney liposarcoma10.2
36fibroblastic liposarcoma10.2
37fibrosarcoma10.2
38neurofibromatosis10.2
39pediatric liposarcoma10.2
40mesenchymoma10.2
41clear cell adenoma10.1
42esophagus liposarcoma10.1
43adult liposarcoma10.1
44cutaneous liposarcoma10.1
45vulvar liposarcoma10.1
46inflammatory liposarcoma10.1
47appendicitis10.1
48cutaneous leiomyosarcoma10.1
49myxoid leiomyosarcoma10.1
50polycystic liver disease10.1

Graphical network of the top 20 diseases related to Myxoid Liposarcoma:



Diseases related to myxoid liposarcoma

Clinical Features for Myxoid Liposarcoma

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46OMIM, 48Orphanet
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Clinical features from OMIM:

613488

Symptoms:

48
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • acute abdominal pain/colic
  • intestinal transit disorder
  • functional anomalies of the kidney and the urinary tract
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • subcutaneous nodules/lipomas/tumefaction/swelling

Drugs & Therapeutics for Myxoid Liposarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Myxoid Liposarcoma

Search NIH Clinical Center for Myxoid Liposarcoma

Search CenterWatch for Myxoid Liposarcoma

Genetic Tests for Myxoid Liposarcoma

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Anatomical Context for Myxoid Liposarcoma

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32MalaCards
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MalaCards organs/tissues related to Myxoid Liposarcoma:

32
Bone, Lung, Kidney, Breast, Myeloid, Liver, Thyroid, Tongue, Salivary gland, Ovary, Uterus, Testis, Testes, Adipocyte, Small intestine, Heart, Bone marrow

Animal Models for Myxoid Liposarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Myxoid Liposarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.6CEBPB, EWSR1, DDIT3, NFKBIZ, HMGA2, PTX3
2MP:00053869.6PRG4, NR1H3, NFKBIZ, WNT1, HMGA2, TSN
3MP:00053759.5EWSR1, PGF, HMGA2, TSN, CEBPB
4MP:00053899.3PDGFA, EWSR1, NR1H3, HMGA2, PTX3, TSN
5MP:00053879.2EWSR1, CREB3L3, DDIT3, NR1H3, NFKBIZ, PGF

Publications for Myxoid Liposarcoma

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50PubMed
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Articles related to Myxoid Liposarcoma:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells. (22570737)
2012
2
Myxoid liposarcoma with negative features on bone scan and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography. (23046828)
2012
3
Recurrent myxoid liposarcoma of the buccal mucosa in a young boy: a case report and review of the literature. (22180120)
2011
4
DDIT3 gene break-apart as a molecular marker for diagnosis of myxoid liposarcoma--assay validation and clinical experience. (22089349)
2011
5
The first case report of a metastatic myxoid liposarcoma invading the left atrial cavity and pulmonary vein. (21859649)
2011
6
A giant primary myxoid liposarcoma of the posterior mediastinum. (20185322)
2010
7
Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. (20215499)
2010
8
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. (20534095)
2010
9
Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy. (19439345)
2009
10
Primary retroperitoneal myxoid/round cell liposarcoma is a nonexisting disease: an immunohistochemical and molecular biological analysis. (18820664)
2009
11
Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. (19190116)
2009
12
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ. (18850010)
2009
13
Myxoid liposarcoma of the breast in a 25-year-old female as a diagnostic pitfall in fine needle aspiration cytology: report of a rare case. (18677756)
2008
14
Subacute complete ophthalmoplegia: an anti-Hu paraneoplastic manifestation of myxoid liposarcoma. (17651257)
2007
15
Myxoid liposarcoma of the lip: correlation of histological and cytological features and review of the literature. (17656299)
2007
16
Fine-needle aspiration biopsy of myxoid liposarcoma metastatic to the liver: cytomorphologic and cytogenetic features. (17924413)
2007
17
Round cell variant of myxoid liposarcoma in a Japanese Macaque (Macaca fuscata). (17317804)
2007
18
FISH mapping of i(7q) in acute leukemias and myxoid liposarcoma reveals clustered breakpoints in 7p11.2: implications for formation and pathogenetic outcome of the idic(7)(p11.2). (16825763)
2006
19
Detection of FUS-CHOP fusion gene in paraffin-embedded tissues and its clinicopathologic significance for myxoid/round cell liposarcomas]. (15796878)
2005
20
High 2-deoxy-2[F-18]fluoro-D-glucose uptake on positron emission tomography in hibernoma originally thought to be myxoid liposarcoma. (15912423)
2005
21
Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas. (15201968)
2004
22
Neck metastasis of a myxoid liposarcoma of the lower extremity. (15571922)
2004
23
Myxoid liposarcoma confirmed by TLS/FUS-CHOP fusion transcripts. (12930346)
2003
24
Unusual skeletal metastases from myxoid liposarcoma only detectable by MR imaging. (15018186)
2003
25
Treatment of myxoid liposarcoma by marginal or intralesional resection combined with radiotherapy. (12926159)
2003
26
Metastatic patterns of extremity myxoid liposarcoma and their outcome. (12173385)
2002
27
Giant metastatic myxoid liposarcoma causing cardiac tamponade: a case report. (12499422)
2002
28
Myxoid liposarcoma of the spermatic cord. (11590296)
2001
29
Myxoid liposarcoma of the supraclavicular fossa. (10807849)
2000
30
Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas. (11229517)
2000
31
Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. (10914725)
2000
32
Retroperitoneal liposarcoma with combined well-differentiated and myxoid malignant fibrous histiocytoma-like myxoid areas. (10584701)
1999
33
Myxoid liposarcoma--the frequency and the natural history of nonpulmonary soft tissue metastases. (10379861)
1999
34
Myxoid liposarcoma of the thigh. (9574593)
1998
35
Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma. (9403703)
1997
36
Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia. (9315104)
1997
37
Primary orbital myxoid liposarcoma presenting as orbital pain. (8600903)
1996
38
Myxoid liposarcoma with cartilaginous differentiation. (8685223)
1996
39
Myxoid liposarcoma of the porta hepatis in childhood. (8152881)
1993
40
Isolation of a yeast artificial chromosome clone that spans the (12;16) translocation breakpoint characteristic of myxoid liposarcoma. (1394104)
1992
41
Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14. (1318779)
1992
42
Myxoid liposarcoma of the cheek. (2179494)
1990
43
Mediastinal involvement by myxoid liposarcoma. (2757450)
1989
44
Cytologic, histologic, and ultrastructural characteristics of a canine myxoid liposarcoma. (2603335)
1989
45
Myxoid liposarcoma of the spermatic cord. (2644493)
1989
46
Myxoid liposarcoma of the right atrium. A case report. (3704877)
1986
47
Myxoid liposarcoma mimicking fluid density. (4079429)
1985
48
Primary myxoid liposarcoma of the larynx. (6435071)
1984
49
Test and teach number one. Myxoid liposarcoma of the thigh. (4138047)
1974
50
Myxoid liposarcoma: a case report. (5658535)
1968

Genetic Variations for Myxoid Liposarcoma

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Expression for genes affiliated with Myxoid Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Myxoid Liposarcoma

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Pathways for genes affiliated with Myxoid Liposarcoma

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37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DDIT3, NR1H3, WNT1, CEBPB
2
Hide members
9.7CEBPB, WNT1, PGF, PRG4, DDIT3, PDGFA
39.7CEBPB, FUS, HMGA2, NFKBIZ, DDIT3, EWSR1

Compounds for genes affiliated with Myxoid Liposarcoma

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44Novoseek, 24HMDB
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Compounds related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4PDGFA
2amino acid4410.1DDIT3, CEBPB
3actinomycin d4410.0DDIT3, POLR2L, HMGA2, PTX3, CEBPB
4vitamin d449.9CEBPB, POLR2L, NR1H3, PDGFA
5phosphatidylinositol449.8DDIT3, PGF, WNT1, CEBPB, PDGFA
6oligonucleotide449.8PDGFA, EWSR1, POLR2L, WNT1, TSN, CEBPB
7retinoic acid44 2410.7CEBPB, PDGFA, EWSR1, DDIT3, NR1H3, POLR2L
8paraffin449.7HMGA2, PGF, EWSR1, PDGFA
9tyrosine449.5PDGFA, EWSR1, DDIT3, PGF, WNT1, PTX3

GO Terms for genes affiliated with Myxoid Liposarcoma

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16Gene Ontology
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Cellular components related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.0ADAD1, CREB3L3, DDIT3, NR1H3, NFKBIZ, POLR2L

Biological processes related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron differentiationGO:03018210.0CEBPB, WNT1, NNAT
2hematopoietic stem cell proliferationGO:07142510.0WNT1, PRG4
3regulation of transcription, DNA-dependentGO:0063559.7DDIT3, NFKBIZ, HMGA2, CEBPZ, CEBPB, EWSR1

Molecular functions related to Myxoid Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.9CEBPB, TSN, NR1H3, DDIT3, CREB3L3
2DNA bindingGO:0036779.2CEBPB, DDIT3, NR1H3, POLR2L, HMGA2, TSN

Products for genes affiliated with Myxoid Liposarcoma

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Sources for Myxoid Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet