Aliases & Classifications for Myxosarcoma

MalaCards integrated aliases for Myxosarcoma:

Name: Myxosarcoma 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4136
MeSH 41 D009236
NCIt 46 C3255
SNOMED-CT 64 28351005
UMLS 69 C0027155

Summaries for Myxosarcoma

MalaCards based summary : Myxosarcoma is related to meninges sarcoma and ring chromosome 7. An important gene associated with Myxosarcoma is MB (Myoglobin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MicroRNAs in cancer. The drugs Belinostat and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and behavior/neurological

Wikipedia : 72 Myxosarcoma is a rare malignant tumor of the... more...

Related Diseases for Myxosarcoma

Diseases related to Myxosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 meninges sarcoma 10.5 MB TP53
2 ring chromosome 7 10.5 MDM2 TP53
3 mesenchymoma 10.5 MB MDM2
4 papillary tumor of the pineal region 10.4 S100A1 SYP
5 orbital cancer 10.4 MB SYP
6 actinic cheilitis 10.4 MDM2 TP53
7 cellular ependymoma 10.4 SYP TP53
8 giant cell myocarditis 10.3 CD68 MB
9 virus associated hemophagocytic syndrome 10.3 CD68 MB
10 atypical follicular adenoma 10.3 SYP TP53
11 sclerosing liposarcoma 10.3 MB MDM2 TP53
12 uterine sarcoma 10.3 ABCB1 MB MDM2
13 cellular schwannoma 10.3 MDM2 S100A1 TP53
14 malignant mesenchymoma 10.3 MB MDM2 TP53
15 muscle cancer 10.3 MB MDM2 TP53
16 central nervous system primitive neuroectodermal neoplasm 10.3 SYP TP53
17 uterine corpus serous adenocarcinoma 10.3 BRCA1 TP53
18 mixed cell type cancer 10.3 MB SYP TP53
19 lip cancer 10.3 MDM2 TP53
20 medullomyoblastoma 10.3 MB SYP TP53
21 cerebellum cancer 10.3 SYP TP53
22 histiocytoma 10.3 MB MDM2 TP53
23 leiomyosarcoma 10.3 MB MDM2 TP53
24 liposarcoma 10.3 MB MDM2 TP53
25 soft tissue sarcoma 10.3 ABCB1 MDM2 TP53
26 cerebral neuroblastoma 10.3 SYP TP53
27 adrenocortical carcinoma, hereditary 10.2 PRKAR1A SYP TP53
28 skin melanoma 10.2 MDM2 NME1 TP53
29 adult medulloblastoma 10.2 MDM2 SYP TP53
30 plica syndrome 10.2 CD68 VWF
31 anal squamous cell carcinoma 10.2 MDM2 TP53
32 giant cell glioblastoma 10.2 MDM2 SYP TP53
33 inflammatory mfh 10.2 CD68 MDM2
34 sarcomatoid squamous cell skin carcinoma 10.2 CD68 MB TP53
35 nervous system cancer 10.2 MDM2 SYP TP53
36 malignant ovarian surface epithelial-stromal neoplasm 10.2 BRCA1 NME1 TP53
37 mixed liposarcoma 10.2 CD68 MB MDM2
38 ovary epithelial cancer 10.2 BRCA1 NME1 TP53
39 ischemic fasciitis 10.2 CD68 MDM2 S100A1
40 ovarian cancer 1 10.1 BRCA1 NME1 TP53
41 fallopian tube adenocarcinoma 10.1 BRCA1 TP53
42 glycogen-rich clear cell breast carcinoma 10.1 BRCA1 SYP TP53
43 breast ductal carcinoma 10.1 BRCA1 NME1 TP53
44 bladder carcinoma in situ 10.1 CD68 TP53
45 synchronous bilateral breast carcinoma 10.1 ATM BRCA1 TP53
46 brain cancer 10.1 ABCB1 SYP TP53
47 nijmegen breakage syndrome 10.1 ATM BRCA1 TP53
48 papillary serous adenocarcinoma 10.1 BRCA1 TP53
49 sporadic breast cancer 10.1 ATM BRCA1 TP53
50 connective tissue cancer 10.1 CD68 MDM2 TP53

Graphical network of the top 20 diseases related to Myxosarcoma:



Diseases related to Myxosarcoma

Symptoms & Phenotypes for Myxosarcoma

GenomeRNAi Phenotypes related to Myxosarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 ANO1 ATM BRCA1 MDM2 NUDT1 TP53

MGI Mouse Phenotypes related to Myxosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 PRKAR1A S100A1 SYP TP53 NUDT1 ABCB1
2 hematopoietic system MP:0005397 10.17 PRKAR1A TP53 VWF ABCB1 CD68 MB
3 cardiovascular system MP:0005385 10.16 PRKAR1A S100A1 TP53 VWF ABCB1 MB
4 homeostasis/metabolism MP:0005376 10.14 VWF PRKAR1A S100A1 TP53 NUDT1 BRCA1
5 immune system MP:0005387 10.07 PRKAR1A TP53 NUDT1 VWF BRCA1 CD68
6 integument MP:0010771 9.92 PRKAR1A TP53 ANO1 MDM2 ATM MLANA
7 muscle MP:0005369 9.8 PRKAR1A S100A1 TP53 BRCA1 MB ANO1
8 neoplasm MP:0002006 9.7 PRKAR1A TP53 NUDT1 MDM2 ATM NME1
9 nervous system MP:0003631 9.65 VWF SYP TP53 NUDT1 BRCA1 ABCB1
10 pigmentation MP:0001186 9.02 PRKAR1A TP53 MDM2 MLANA BRCA1

Drugs & Therapeutics for Myxosarcoma

Drugs for Myxosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Belinostat Approved, Investigational Phase 1 866323-14-0
2
Fluorouracil Approved Phase 1 51-21-8 3385
3 Androgens Phase 1
4 Antimetabolites Phase 1
5 Antimetabolites, Antineoplastic Phase 1
6 Histone Deacetylase Inhibitors Phase 1
7 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Myxosarcoma

Cochrane evidence based reviews: myxosarcoma

Genetic Tests for Myxosarcoma

Anatomical Context for Myxosarcoma

MalaCards organs/tissues related to Myxosarcoma:

38
Heart, Lung, Brain, Skin, Pituitary, Eye, Bone

Publications for Myxosarcoma

Articles related to Myxosarcoma:

(show top 50) (show all 60)
# Title Authors Year
1
Metastatic myxosarcoma in a Quarter Horse gelding. ( 28677418 )
2017
2
What Is Your Diagnosis? Myxosarcoma in a cat. ( 26331415 )
2015
3
Metronomic Chemotherapy for Myxosarcoma Treatment in a Kori Bustard (Ardeotis kori). ( 26378667 )
2015
4
Long-term survival after extended resection of primary atrial myxosarcoma. ( 25583907 )
2015
5
Myxosarcoma of the maxilla - a case report. ( 25954712 )
2015
6
Canine low-grade intra-orbital myxosarcoma: case report. ( 24837165 )
2014
7
Diagnosis and treatment of a periocular myxosarcoma in a bearded dragon (Pogona vitticeps). ( 24982518 )
2014
8
Axillary artery tumor embolism secondary to mitral valve myxosarcoma in a dog. ( 25471647 )
2014
9
What is your diagnosis? Grade 2 myxosarcoma of the subcutis and bone. ( 25406700 )
2014
10
Cardiac myxosarcoma with thoracic spinal metastasis. ( 23677508 )
2013
11
What is your diagnosis? Low-grade myxosarcoma arising from the heart valve. ( 23547667 )
2013
12
Intrathoracic myxosarcoma in a dog. ( 22520813 )
2012
13
Cutaneous myxosarcoma with pulmonary metastases in a dog. ( 21310431 )
2011
14
Surgical treatment of cardiac myxosarcoma. ( 21484557 )
2011
15
Multiple cerebral aneurysms and brain metastasis from primary cardiac myxosarcoma: a case report and literature review. ( 21733362 )
2011
16
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog. ( 20110224 )
2010
17
Primary myxosarcoma of the right inferior pulmonary vein presenting clinically as benign left atrial myxoma with a concurrent right lower lung tumor. ( 19139592 )
2009
18
Imaging features of orbital myxosarcoma in dogs. ( 18546781 )
2008
19
Endobronchial polyp derived from a myxosarcoma in the lung of a dog. ( 18981198 )
2008
20
Imaging diagnosis--spinal myxosarcoma in a dog. ( 18018729 )
2007
21
Left atrium myxosarcoma: an exceptional cardiac malignant primary tumor. ( 17551954 )
2007
22
Odontogenic myxosarcoma of the jaw in a dog. ( 17993660 )
2007
23
Left atrial myxosarcoma with previously detected intestinal metastasis. ( 17420810 )
2007
24
Carpal myxosarcoma and forelimb amputation in a ferret (Mustela putorius furo). ( 17142629 )
2006
25
Spontaneous subcutaneous myxosarcoma in a captive European hedgehog (Erinsceus europaeus). ( 17121099 )
2006
26
Myxosarcoma of the right ventricle: an immunohistochemical and ultrastructural study. ( 12926105 )
2003
27
Left ventricular myxosarcoma in a dog. ( 14635963 )
2003
28
Myxosarcoma in the eye and brain in a dog. ( 12950648 )
2003
29
Myxosarcoma: a rare primary cardiac tumor. ( 12517027 )
2002
30
Nasopharyngeal myxosarcoma in a Bengal tiger (Panthera tigris). ( 12564536 )
2002
31
Cardiac myxoma and myxosarcoma: clinical experience and immunohistochemistry. ( 12079962 )
2002
32
Left atrial myxosarcoma with systemic metastasis: a case report. ( 11289388 )
2001
33
Right atrial myxosarcoma in a dog. ( 9561500 )
1997
34
Primary left atrial myxosarcoma. ( 7691044 )
1993
35
Surgical treatment of pulmonary artery primary myxosarcoma. ( 8599076 )
1993
36
Intestinal myxosarcoma in a thoroughbred mare. ( 1623729 )
1992
37
Myxosarcoma in a Sinaloan milksnake. ( 1813474 )
1991
38
Myxosarcoma in a dog. ( 12684949 )
1990
39
Cytogenetic analysis of a gossypol-induced murine myxosarcoma. ( 3473256 )
1987
40
A case of malignant myxoma (myxosarcoma) of the maxilla. ( 6591371 )
1984
41
Myxosarcoma in a wapiti. ( 480522 )
1979
42
Primary cardiac myxosarcoma in a child. ( 423607 )
1979
43
Recurrent myxosarcoma of left atrium. ( 1126234 )
1975
44
Myxosarcoma in a young rhesus monkey. ( 809897 )
1975
45
Spontaneous myxosarcoma in a cottontail rabbit (Sylvilagus floridanus): observation of tubular structures in the endoplasmic reticulum of tumor cells. ( 4737213 )
1973
46
Myxosarcoma of the pulmonary valve. ( 5082046 )
1972
47
Myxosarcoma of the orbit (a case report). ( 15744961 )
1971
48
Primary myxosarcoma of leg. ( 4905664 )
1970
49
Properties of hyaluronic acid from a human myxosarcoma. ( 5870108 )
1965
50
MYXOSARCOMA OF THE PENIS: A CASE REPORT. ( 14346457 )
1965

Variations for Myxosarcoma

Expression for Myxosarcoma

Search GEO for disease gene expression data for Myxosarcoma.

Pathways for Myxosarcoma

Pathways related to Myxosarcoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 ATM BRCA1 MDM2 TP53 VWF
2 12.4 ABCB1 ATM BRCA1 MDM2 TP53
3 12.36 ATM BRCA1 MDM2 NUDT1 TP53
4
Show member pathways
12.25 ATM BRCA1 MDM2 TP53
5
Show member pathways
12.12 ATM BRCA1 MDM2 TP53
6 12.02 ATM BRCA1 MDM2 TP53
7 11.86 ATM MDM2 TP53
8
Show member pathways
11.7 ATM BRCA1 TP53
9 11.68 NME1 NME2 TP53
10
Show member pathways
11.64 ATM BRCA1 MDM2 TP53
11
Show member pathways
11.63 ATM MDM2 TP53
12 11.56 ATM BRCA1 TP53
13 11.5 ATM MDM2 TP53
14 11.32 ATM BRCA1 MDM2 TP53
15 11.19 ATM BRCA1 TP53
16 11.14 BRCA1 MDM2 TP53
17 11.1 ATM BRCA1 TP53
18
Show member pathways
10.95 ATM MDM2 TP53
19 10.92 ATM BRCA1 MDM2 TP53
20 10.85 ABCB1 NME1 NME2
21 10.78 ATM BRCA1 TP53
22 10.73 NME1 NME2
23 10.69 ABCB1 TP53
24 10.69 ABCB1 NME1 NME2
25 10.57 ATM BRCA1 MDM2 TP53
26 10.48 NME1 NME2

GO Terms for Myxosarcoma

Cellular components related to Myxosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 9.02 BRCA1 MDM2 PRKAR1A S100A1 TP53

Biological processes related to Myxosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.86 ABCB1 MDM2 NME1 TP53
2 regulation of apoptotic process GO:0042981 9.84 ATM BRCA1 NME1 TP53
3 heart development GO:0007507 9.71 ATM MB MDM2 PRKAR1A
4 positive regulation of protein export from nucleus GO:0046827 9.58 MDM2 TP53
5 nucleoside diphosphate phosphorylation GO:0006165 9.57 NME1 NME2
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.55 BRCA1 TP53
7 DNA double-strand break processing GO:0000729 9.52 ATM BRCA1
8 determination of adult lifespan GO:0008340 9.51 ATM TP53
9 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 ATM MDM2 TP53
10 replicative senescence GO:0090399 9.49 ATM TP53
11 GTP biosynthetic process GO:0006183 9.48 NME1 NME2
12 CTP biosynthetic process GO:0006241 9.46 NME1 NME2
13 regulation of signal transduction by p53 class mediator GO:1901796 9.46 ATM BRCA1 MDM2 TP53
14 UTP biosynthetic process GO:0006228 9.43 NME1 NME2
15 cellular response to organic substance GO:0071310 9.43 CD68 MDM2 SYP
16 female meiotic nuclear division GO:0007143 9.37 ATM PRKAR1A
17 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
18 cellular response to gamma radiation GO:0071480 8.8 ATM MDM2 TP53

Molecular functions related to Myxosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 MDM2 NME1 S100A1 SYP TP53 VWF
2 nucleoside diphosphate kinase activity GO:0004550 9.26 NME1 NME2
3 ubiquitin protein ligase binding GO:0031625 9.26 BRCA1 MDM2 PRKAR1A TP53
4 protein N-terminus binding GO:0047485 8.92 ATM MDM2 TP53 VWF

Sources for Myxosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....