Aliases & Classifications for Myxosarcoma

MalaCards integrated aliases for Myxosarcoma:

Name: Myxosarcoma 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4136
MeSH 42 D009236
NCIt 47 C3255
SNOMED-CT 64 28351005
UMLS 69 C0027155

Summaries for Myxosarcoma

MalaCards based summary : Myxosarcoma is related to 2q31.1 microdeletion syndrome and cowper gland carcinoma. An important gene associated with Myxosarcoma is MB (Myoglobin), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. The drugs Belinostat and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Myxosarcoma is a rare malignant tumor of the... more...

Related Diseases for Myxosarcoma

Diseases related to Myxosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 2q31.1 microdeletion syndrome 10.8 S100A1 SYP
2 cowper gland carcinoma 10.7 MB TP53
3 transitional cell carcinoma 10.7 MB MDM2
4 chondroid chordoma 10.7 MB SYP
5 rnase t2-deficient leukoencephalopathy 10.6 MDM2 TP53
6 acute cholinergic dysautonomia 10.6 MDM2 TP53
7 embryonal extrahepatic bile duct rhabdomyosarcoma 10.6 MB TP53
8 gigantism 10.5 CD68 MB
9 congenital granular cell tumor 10.5 SYP TP53
10 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.5 SYP TP53
11 visual snow syndrome 10.5 CD68 MB
12 rectum squamous cell carcinoma 10.5 MDM2 TP53
13 lichen nitidus 10.5 MDM2 TP53
14 brain glioma 10.5 SYP TP53
15 hair disease 10.5 SYP TP53
16 rh isoimmunization 10.5 SYP TP53
17 vagina, absence of 10.5 ABCB1 MB MDM2
18 vulvar liposarcoma 10.5 MB MDM2 TP53
19 pleural empyema 10.4 SYP TP53
20 lung clear cell-sugar-tumor 10.4 MB MDM2 TP53
21 c-p angle neurinoma 10.4 MDM2 S100A1 TP53
22 mediastinum rhabdomyosarcoma 10.4 MB MDM2 TP53
23 spindle cell sarcoma 10.4 MB MDM2 TP53
24 hypersensitivity reaction type iii disease 10.4 MB SYP TP53
25 melanotic medulloblastoma 10.4 MB SYP TP53
26 adenosarcoma 10.4 MB MDM2 TP53
27 accessory nerve disease 10.4 MB MDM2 TP53
28 chest wall lymphoma 10.4 ATM TP53
29 anaplastic oligodendroglioma 10.4 MDM2 SYP
30 reactive arthritis 10.4 CD68 MDM2
31 sparse hair ptosis mental retardation 10.4 ABCB1 MDM2 TP53
32 atrophic gastritis 10.4 MDM2 NME1 TP53
33 basal cell carcinoma 7 10.3 PRKAR1A SYP TP53
34 childhood choroid plexus cancer 10.3 SYP TP53
35 ritter's disease 10.3 CD68 TP53
36 anal margin squamous cell carcinoma 10.3 CD68 VWF
37 brachial plexus neuritis 10.3 SYP TP53
38 childhood medulloblastoma 10.3 MDM2 SYP TP53
39 retinal detachment 10.3 SYP TP53
40 fallopian tube squamous cell carcinoma 10.3 CD68 MB TP53
41 juvenile astrocytoma 10.3 MDM2 SYP TP53
42 small cell sarcoma 10.3 MDM2 SYP TP53
43 median neuropathy 10.3 CD68 MB MDM2
44 neurofibroma of the esophagus 10.2 CD68 MDM2 S100A1
45 penis paget's disease 10.2 CD68 TP53
46 nodular goiter 10.2 ABCB1 SYP TP53
47 ladd syndrome 10.2 MDM2 NME1 TP53
48 nasopharyngeal carcinoma 10.2 ATM MDM2 TP53
49 brenner tumor of the vagina 10.2 ATM TP53
50 brain stem infarction 10.2 CD68 MDM2

Graphical network of the top 20 diseases related to Myxosarcoma:



Diseases related to Myxosarcoma

Symptoms & Phenotypes for Myxosarcoma

MGI Mouse Phenotypes related to Myxosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 ABCB1 ANO1 ATM MB MDM2 PRKAR1A
2 hematopoietic system MP:0005397 9.65 TP53 VWF ABCB1 ATM CD68 MB
3 neoplasm MP:0002006 9.1 ATM MDM2 NME1 NUDT1 PRKAR1A TP53

Drugs & Therapeutics for Myxosarcoma

Drugs for Myxosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Belinostat Approved, Investigational Phase 1 866323-14-0
2
Fluorouracil Approved Phase 1 51-21-8 3385
3 Androgens Phase 1
4 Antimetabolites Phase 1
5 Antimetabolites, Antineoplastic Phase 1
6 Histone Deacetylase Inhibitors Phase 1
7 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)

Search NIH Clinical Center for Myxosarcoma

Cochrane evidence based reviews: myxosarcoma

Genetic Tests for Myxosarcoma

Anatomical Context for Myxosarcoma

MalaCards organs/tissues related to Myxosarcoma:

39
Heart, Lung, Brain, Skin, Pituitary, Eye, Bone

Publications for Myxosarcoma

Articles related to Myxosarcoma:

(show top 50) (show all 60)
id Title Authors Year
1
Metastatic myxosarcoma in a Quarter Horse gelding. ( 28677418 )
2017
2
Myxosarcoma of the maxilla - a case report. ( 25954712 )
2015
3
Metronomic Chemotherapy for Myxosarcoma Treatment in a Kori Bustard (Ardeotis kori). ( 26378667 )
2015
4
Long-term survival after extended resection of primary atrial myxosarcoma. ( 25583907 )
2015
5
What Is Your Diagnosis? Myxosarcoma in a cat. ( 26331415 )
2015
6
Canine low-grade intra-orbital myxosarcoma: case report. ( 24837165 )
2014
7
Axillary artery tumor embolism secondary to mitral valve myxosarcoma in a dog. ( 25471647 )
2014
8
Diagnosis and treatment of a periocular myxosarcoma in a bearded dragon (Pogona vitticeps). ( 24982518 )
2014
9
What is your diagnosis? Grade 2 myxosarcoma of the subcutis and bone. ( 25406700 )
2014
10
Cardiac myxosarcoma with thoracic spinal metastasis. ( 23677508 )
2013
11
What is your diagnosis? Low-grade myxosarcoma arising from the heart valve. ( 23547667 )
2013
12
Intrathoracic myxosarcoma in a dog. ( 22520813 )
2012
13
Cutaneous myxosarcoma with pulmonary metastases in a dog. ( 21310431 )
2011
14
Multiple cerebral aneurysms and brain metastasis from primary cardiac myxosarcoma: a case report and literature review. ( 21733362 )
2011
15
Surgical treatment of cardiac myxosarcoma. ( 21484557 )
2011
16
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog. ( 20110224 )
2010
17
Primary myxosarcoma of the right inferior pulmonary vein presenting clinically as benign left atrial myxoma with a concurrent right lower lung tumor. ( 19139592 )
2009
18
Imaging features of orbital myxosarcoma in dogs. ( 18546781 )
2008
19
Endobronchial polyp derived from a myxosarcoma in the lung of a dog. ( 18981198 )
2008
20
Left atrial myxosarcoma with previously detected intestinal metastasis. ( 17420810 )
2007
21
Odontogenic myxosarcoma of the jaw in a dog. ( 17993660 )
2007
22
Left atrium myxosarcoma: an exceptional cardiac malignant primary tumor. ( 17551954 )
2007
23
Imaging diagnosis--spinal myxosarcoma in a dog. ( 18018729 )
2007
24
Spontaneous subcutaneous myxosarcoma in a captive European hedgehog (Erinsceus europaeus). ( 17121099 )
2006
25
Carpal myxosarcoma and forelimb amputation in a ferret (Mustela putorius furo). ( 17142629 )
2006
26
Left ventricular myxosarcoma in a dog. ( 14635963 )
2003
27
Myxosarcoma of the right ventricle: an immunohistochemical and ultrastructural study. ( 12926105 )
2003
28
Myxosarcoma in the eye and brain in a dog. ( 12950648 )
2003
29
Myxosarcoma: a rare primary cardiac tumor. ( 12517027 )
2002
30
Cardiac myxoma and myxosarcoma: clinical experience and immunohistochemistry. ( 12079962 )
2002
31
Nasopharyngeal myxosarcoma in a Bengal tiger (Panthera tigris). ( 12564536 )
2002
32
Left atrial myxosarcoma with systemic metastasis: a case report. ( 11289388 )
2001
33
Right atrial myxosarcoma in a dog. ( 9561500 )
1997
34
Surgical treatment of pulmonary artery primary myxosarcoma. ( 8599076 )
1993
35
Primary left atrial myxosarcoma. ( 7691044 )
1993
36
Intestinal myxosarcoma in a thoroughbred mare. ( 1623729 )
1992
37
Myxosarcoma in a Sinaloan milksnake. ( 1813474 )
1991
38
Myxosarcoma in a dog. ( 12684949 )
1990
39
Cytogenetic analysis of a gossypol-induced murine myxosarcoma. ( 3473256 )
1987
40
A case of malignant myxoma (myxosarcoma) of the maxilla. ( 6591371 )
1984
41
Primary cardiac myxosarcoma in a child. ( 423607 )
1979
42
Myxosarcoma in a wapiti. ( 480522 )
1979
43
Recurrent myxosarcoma of left atrium. ( 1126234 )
1975
44
Myxosarcoma in a young rhesus monkey. ( 809897 )
1975
45
Spontaneous myxosarcoma in a cottontail rabbit (Sylvilagus floridanus): observation of tubular structures in the endoplasmic reticulum of tumor cells. ( 4737213 )
1973
46
Myxosarcoma of the pulmonary valve. ( 5082046 )
1972
47
Myxosarcoma of the orbit (a case report). ( 15744961 )
1971
48
Primary myxosarcoma of leg. ( 4905664 )
1970
49
MYXOSARCOMA OF THE PENIS: A CASE REPORT. ( 14346457 )
1965
50
Properties of hyaluronic acid from a human myxosarcoma. ( 5870108 )
1965

Variations for Myxosarcoma

Expression for Myxosarcoma

Search GEO for disease gene expression data for Myxosarcoma.

Pathways for Myxosarcoma

GO Terms for Myxosarcoma

Biological processes related to Myxosarcoma according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 regulation of signal transduction by p53 class mediator GO:1901796 9.72 ATM MDM2 TP53
2 heart development GO:0007507 9.71 ATM MB MDM2 PRKAR1A
3 positive regulation of protein export from nucleus GO:0046827 9.54 MDM2 TP53
4 nucleoside diphosphate phosphorylation GO:0006165 9.52 NME1 NME2
5 determination of adult lifespan GO:0008340 9.51 ATM TP53
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 ATM MDM2 TP53
7 CTP biosynthetic process GO:0006241 9.49 NME1 NME2
8 GTP biosynthetic process GO:0006183 9.48 NME1 NME2
9 replicative senescence GO:0090399 9.46 ATM TP53
10 UTP biosynthetic process GO:0006228 9.43 NME1 NME2
11 cellular response to organic substance GO:0071310 9.43 CD68 MDM2 SYP
12 female meiotic division GO:0007143 9.37 ATM PRKAR1A
13 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
14 negative regulation of myeloid leukocyte differentiation GO:0002762 8.96 NME1 NME2
15 cellular response to gamma radiation GO:0071480 8.8 ATM MDM2 TP53

Molecular functions related to Myxosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.5 MDM2 NME2 TP53
2 identical protein binding GO:0042802 9.43 MDM2 NME1 S100A1 SYP TP53 VWF
3 nucleoside diphosphate kinase activity GO:0004550 9.26 NME1 NME2
4 intermediate filament binding GO:0019215 9.16 NME1 NME2
5 protein N-terminus binding GO:0047485 8.92 ATM MDM2 TP53 VWF

Sources for Myxosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....