MCID: NLD001
MIFTS: 47

Nail Disease

Categories: Skin diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Nail Disease

Summaries for Nail Disease

MedlinePlus : 41 your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards based summary : Nail Disease, also known as nail diseases, is related to nail-patella syndrome and paronychia, and has symptoms including exanthema, pruritus and clubbing of nail. An important gene associated with Nail Disease is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways are Signaling in Gap Junctions and Proteoglycans in cancer. The drugs Chlorhexidine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and heart.

Disease Ontology : 12 An integumentary system disease that is located in nail.

Wikipedia : 72 A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

Related Diseases for Nail Disease

Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 3, Nail Disorder, Nonsyndromic Congenital, 10,
Nail Disorder, Nonsyndromic Congenital, 7 Nail Disorder, Nonsyndromic Congenital, 9
Nail Disorder, Nonsyndromic Congenital, 1 Nonsyndromic Congenital Nail Disorder 2
Nonsyndromic Congenital Nail Disorder 5 Nonsyndromic Congenital Nail Disorder 6

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 nail-patella syndrome 10.7
2 paronychia 10.6
3 tooth agenesis, selective, 4 10.5
4 keratosis palmoplantaris striata ii 10.5
5 severe pre-eclampsia 10.0 EGFR KRAS
6 tubular adenocarcinoma 10.0 EGFR KRAS
7 breast adenoid cystic carcinoma 10.0 EGFR KRAS
8 spindle epithelial tumor with thymus-like differentiation tumor 10.0 EGFR KRAS
9 congenital mesoblastic nephroma 10.0 EGFR KRAS
10 occupational dermatitis 10.0 EGFR KRAS
11 gorham's disease 10.0 EGFR KRAS
12 psoriatic arthritis 9.9
13 arthritis 9.9
14 sohval soffer syndrome 9.9 EGFR KRAS
15 cecum adenocarcinoma 9.9 EGFR KRAS
16 psoriasis 9.9
17 early congenital syphilis 9.9 EGFR KRAS
18 olfactory neuroblastoma 9.9 EGFR KRAS
19 sebaceous adenocarcinoma 9.8 EGFR KRAS
20 pancreatic somatostatinoma 9.8 EGFR KRAS
21 nail disorder, nonsyndromic congenital, 10, 9.8
22 endometriosis of uterus 9.7 EGFR KRAS
23 pancreatic serous cystic neoplasm 9.7 EGFR KRAS
24 enthesopathy 9.6
25 arteritic anterior ischemic optic neuropathy 9.6 EGFR KRAS
26 pemphigus vulgaris 9.5
27 lymphoma 9.5
28 dermatophytosis 9.5
29 pemphigus 9.5
30 trachea squamous cell carcinoma 9.4 EGFR KRAS
31 brown-vialetto-van laere syndrome 1 9.0 CEP76 ESCO1 RSPO4 ZNF519
32 common bile duct disease 7.1 CEP76 EGFR ESCO1 FZD6 KRAS PLCD1

Graphical network of the top 20 diseases related to Nail Disease:



Diseases related to Nail Disease

Symptoms & Phenotypes for Nail Disease

UMLS symptoms related to Nail Disease:


exanthema, pruritus, clubbing of nail

Drugs & Therapeutics for Nail Disease

Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2
Ethanol Approved Phase 4,Phase 3 64-17-5 702
3
Phenol Approved, Experimental Phase 4 108-95-2 996
4
Ciclopirox Approved, Investigational Phase 4,Phase 3,Phase 2 29342-05-0 2749
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
6
Bifonazole Approved Phase 4,Phase 3 60628-96-8 2378
7
Terbinafine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 91161-71-6 5402 1549008
8
Lenograstim Approved Phase 4 135968-09-1
9
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
10
Etanercept Approved, Investigational Phase 4 185243-69-0
11
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
12
Tazarotene Approved, Investigational Phase 4,Phase 2 118292-40-3 5381
13
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
14
Efinaconazole Approved Phase 4,Phase 3 164650-44-6
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
16
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 2 59-67-6 938
17
Nicotinamide Approved, Nutraceutical Phase 4,Phase 2 98-92-0 936
18
Docetaxel Approved May 1996, Investigational Phase 4,Phase 3 114977-28-5 148124 9877265
19 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Anti-Infective Agents, Local Phase 4
21 Central Nervous System Depressants Phase 4,Phase 3
22 Chlorhexidine gluconate Phase 4
23 Dermatologic Agents Phase 4,Phase 2,Phase 3
24 Disinfectants Phase 4
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
26 Amorolfine Phase 4,Phase 3,Phase 2,Phase 1
27 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2
29 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
31 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
32 Hormones Phase 4,Phase 3,Phase 2,Phase 1
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
34 Keratolytic Agents Phase 4,Phase 3,Phase 2
35 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
36 Adrenocorticotropic Hormone Phase 4
37 beta-endorphin Phase 4
38 Melanocyte-Stimulating Hormones Phase 4
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
42 Vitamin B Complex Phase 4,Phase 3,Phase 2
43 Polyhexamethylene biguanide Phase 4
44 Adjuvants, Immunologic Phase 4
45 Antimitotic Agents Phase 4,Phase 3
46 Hydroxyitraconazole Phase 4,Phase 3,Phase 2
47 Analgesics Phase 4,Phase 3,Phase 2
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
49 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 192)

id Name Status NCT ID Phase Drugs
1 Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy Unknown status NCT01844141 Phase 4 70% alcohol;70% alcohol - 0.5% clorhexidine
2 Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
3 Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis Unknown status NCT02436291 Phase 4
4 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
5 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
6 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
7 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4 Polihexanide
8 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
9 Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish Completed NCT02321098 Phase 4 Loceryl Nail Lacquer;Loceryl Nail Lacquer;Loceryl Nail Lacquer follow up period
10 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% Completed NCT02705664 Phase 4 Loceryl Nail Lacquer;Urea Ointment;Bifonazole Cream
11 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer Completed NCT02679911 Phase 4 Loceryl Nail Lacquer;Ciclopirox Nail Lacquer
12 Topical Penlac Nail Lacquer for Onychomycosis in Children Completed NCT01419847 Phase 4 Ciclopirox;Placebo
13 A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment Completed NCT02464826 Phase 4 Nailprotex
14 Scoring Clinical Index For Onychomycosis in Toenail Onychomycosis Treating With Itraconazole Capsules Completed NCT00871728 Phase 4 Itraconazole
15 Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis Completed NCT01851590 Phase 4 Amorolfine;Terbinafine
16 Proximal Femoral Nail Antirotation™ (PFNA) Versus Gamma Nail 3™ (Gamma3) for Intramedullary Nailing of Unstable Trochanteric Fractures Completed NCT00736684 Phase 4
17 Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis Completed NCT00581100 Phase 4 etanercept
18 Evaluation of the Efficacy of Acitretin Therapy for Nail Psoriasis Completed NCT00723437 Phase 4 acitretin
19 Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis Recruiting NCT02812043 Phase 4 Amorolfine
20 Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis Recruiting NCT02812771 Phase 4 Efinaconazole
21 Study Evaluating the Effect of Jublia on Dermatophytomas Active, not recruiting NCT03098615 Phase 4 Jublia (Efinaconazole 10% Topical Solution)
22 Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish Active, not recruiting NCT03110029 Phase 4 Efinaconazole 10% (Jublia)
23 Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic Nail Disease Not yet recruiting NCT03263624 Phase 4 Tazarotene Cream 0.1%
24 An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Apremilast for the Treatment of Nail Psoriasis Not yet recruiting NCT03022617 Phase 4 Apremilast
25 Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis Not yet recruiting NCT03280927 Phase 4 Jublia®
26 Addition of Excimer Laser to Treatment With Acitretin Tablets for Psoriasis of the Palms and Soles Terminated NCT02181790 Phase 4 Acitretin
27 TDT 067 Onychomycosis Study Unknown status NCT01145807 Phase 3 TDT067;Placebo;Transfersome
28 Treating Onychomychosis Unknown status NCT00776464 Phase 2, Phase 3
29 Pilot Study of Efficacy of Nail Gel in Finger Nail Surface Abnormality Unknown status NCT02582762 Phase 3 Nail gel
30 Evaluation of the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Breast or Prostate Cancer Completed NCT00925418 Phase 3
31 Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail. Completed NCT00356915 Phase 3 Itraconazole 100mg capsules;Itraconazole 200mg tablets;Placebo tablets
32 Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443820 Phase 3 terbinafine;Placebo;terbinafine;Placebo
33 Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443898 Phase 3 terbinafine;Placebo;terbinafine;Placebo
34 Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis Completed NCT00459537 Phase 3 terbinafine hydrogen chloride;amorolfine nail lacquer
35 Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste Completed NCT00781820 Phase 3 Bifonazole cream 1%;Placebo cream
36 Clinical Trial on Onychomycosis With P-3058 Nail Solution in Pediatric Population Completed NCT02547701 Phase 3 P-3058
37 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
38 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
39 PinPointe FootLaser for the Treatment of Onychomycosis Completed NCT00935649 Phase 2, Phase 3
40 Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis Completed NCT01431820 Phase 2, Phase 3 Luliconazole Solution, 10%;Vehicle Solution
41 Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01008033 Phase 3 IDP-108;Vehicle
42 The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01007708 Phase 3 IDP-108;Vehicle
43 Evaluation of the Efficacy and Safety of Indigo Naturalis Oil Extract on Psoriatic Nails Completed NCT00999687 Phase 2, Phase 3 Indigo Naturalis Extract in Oil
44 Study to Evaluate the Efficacy and Safety of P-3073 Nail Solution in the Treatment of Nails Affected by Psoriasis Completed NCT02606760 Phase 3 P-3073;Vehicle of P-3073
45 A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis Completed NCT02016482 Phase 3
46 Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Nail Psoriasis Completed NCT01807520 Phase 3
47 Comparison of Indigo Naturalis Oil Extract and Calcipotriol Solution in Treating Psoriasis Completed NCT01445886 Phase 2, Phase 3 Indigo Naturalis Oil Extract;Calcipotriol Solution
48 Study to Evaluate the Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Recruiting NCT02866032 Phase 3 MOB015B;Ciclopirox 80 mg/g
49 A Multi-centre, Double-blind, Randomized, Vehicle-controlled Study of Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Recruiting NCT02859519 Phase 3 MOB015B;MOB015B Vehicle
50 Efficacy and Safety of Efinaconazole 10% Solution in the Treatment of Onychomycosis in Diabetic Patients Recruiting NCT03168841 Phase 3 Efinaconazole Topical

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

Genetic Tests for Nail Disease

Genetic tests related to Nail Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Nail 29

Anatomical Context for Nail Disease

MalaCards organs/tissues related to Nail Disease:

39
Skin, Kidney, Heart, Lung, Liver, Bone, Breast

Publications for Nail Disease

Articles related to Nail Disease:

(show top 50) (show all 53)
id Title Authors Year
1
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. ( 27932277 )
2016
2
Nail Disease for the Primary Care Provider. ( 26476249 )
2015
3
Ultrasound in the management of nail disease. ( 26895940 )
2015
4
Psoriatic nail disease, a predictor of psoriatic arthritis. ( 25409998 )
2014
5
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. ( 23988587 )
2013
6
Metoprolol-induced psoriatic nail disease. ( 22724586 )
2013
7
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. ( 23423871 )
2013
8
Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. ( 24117389 )
2013
9
Drug-related nail disease. ( 24079591 )
2013
10
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. ( 22156725 )
2012
11
Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis. ( 22337245 )
2012
12
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. ( 22383354 )
2012
13
Assessment of psoriatic nail disease activity by rheumatologists: comment on the article by Lubrano et al. ( 22623218 )
2012
14
Optical coherence tomography: a new tool to assess nail disease in psoriasis? ( 21791896 )
2011
15
Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index. ( 21174373 )
2010
16
Nutrition and nail disease. ( 20620759 )
2010
17
Nail disease in pemphigus vulgaris. ( 19903430 )
2009
18
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? ( 19424069 )
2009
19
Management of psoriatic nail disease. ( 19341941 )
2009
20
Clinical practice. Fungal nail disease. ( 19439745 )
2009
21
Psoriatic nail disease: quality of life and treatment. ( 19799826 )
2009
22
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. ( 18083272 )
2008
23
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. ( 16673801 )
2006
24
Therapies for psoriatic nail disease. A systematic review. ( 16724366 )
2006
25
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? ( 16546613 )
2006
26
Alefacept in the treatment of psoriatic nail disease: a small case series. ( 15928640 )
2005
27
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. ( 18360572 )
2005
28
Extended report: nail disease in psoriatic arthritis--clinically important, potentially treatable and often overlooked. ( 15113998 )
2004
29
Molecular genetics of hereditary hair and nail disease. ( 15468149 )
2004
30
Observer agreement in recording the clinical signs of nail disease and the accuracy of a clinical diagnosis of fungal and non-fungal nail disease. ( 12653750 )
2003
31
One interpretation of a psychometric study of patients with nail disease. ( 12664041 )
2003
32
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. ( 11501665 )
2001
33
Psoriatic arthritis, nail disease and pustules following Hodgkin's lymphoma. ( 10952760 )
2000
34
Nail disease: antifungals have similar cure rates, different side-effects. ( 10570567 )
1999
35
Manual of nail disease and surgery ( 9767626 )
1998
36
Itraconazole now indicated to treat fungal nail disease. ( 11361668 )
1996
37
The differential diagnosis of nail disease. ( 11361432 )
1995
38
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology). ( 7496239 )
1995
39
Pediatric nail disease. ( 7742236 )
1995
40
Lamisil -- A New Measure in Antifungal Therapy in Skin and Nail Disease. Proceedings of a symposium. Vienna, Austria, 18 May 1993. ( 7910478 )
1994
41
Oral therapeutic agents in fungal nail disease. ( 8077514 )
1994
42
Epidemiology of fungal skin and nail disease: roundtable discussion held at Dermatology 2000, Vienna, 17 May 1993. ( 8186144 )
1994
43
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. ( 1381758 )
1992
44
Single dose treatment of fungal nail disease. ( 1349100 )
1992
45
The spectrum of nail disease in patients with human immunodeficiency virus infection. ( 1619083 )
1992
46
Nail disease. ( 2018711 )
1991
47
A systematic approach to examining the patient with nail disease. ( 2650839 )
1989
48
Nail disease and dermatology. ( 2681287 )
1989
49
Hand, foot and nail disease--a common manifestation of chronic dermatophytosis. ( 3231234 )
1988
50
Candida onychomycosis--an evaluation of the role of Candida species in nail disease. ( 3342176 )
1988

Variations for Nail Disease

ClinVar genetic disease variations for Nail Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FZD6 NM_003506.3(FZD6): c.1750G> T (p.Glu584Ter) single nucleotide variant Pathogenic rs151339002 GRCh37 Chromosome 8, 104342091: 104342091
2 FZD6 NM_003506.3(FZD6): c.1531C> T (p.Arg511Cys) single nucleotide variant Pathogenic rs151339003 GRCh37 Chromosome 8, 104340634: 104340634

Expression for Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Pathways for Nail Disease

GO Terms for Nail Disease

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.26 EGFR KRAS
2 epidermal growth factor receptor signaling pathway GO:0007173 9.16 EGFR KRAS
3 hair follicle development GO:0001942 8.96 EGFR FZD6
4 ERBB2 signaling pathway GO:0038128 8.62 EGFR KRAS

Sources for Nail Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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