MCID: NLD001
MIFTS: 34

Nail Disease malady

Skin diseases category

Summaries for Nail Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards: Nail Disease, also known as nail diseases, is related to psoriatic arthritis and arthritis. An important gene associated with Nail Disease is PLCD1 (phospholipase C, delta 1), and among its related pathways is Cell Cycle. Affiliated tissues include nail, skin and kidney.

Disease Ontology:8 An integumentary system disease that is located in nail.

Wikipedia:63 Nail diseases are distinct from diseases of the skin. Although nails are a skin appendage, they have... more...

Aliases & Classifications for Nail Disease

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Nail Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 10, Nail Disorder, Nonsyndromic Congenital, 9

Diseases related to Nail Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis10.3
2arthritis10.3
3psoriasis10.3
4skin disease10.1
5anonychia congenita10.0RSPO4
6paronychia9.9
7pemphigus9.9
8bone development disease9.9
9dermatophytosis9.9
10enthesopathy9.9
11hair disease9.9
12hodgkin's lymphoma9.9

Graphical network of diseases related to Nail Disease:



Diseases related to nail disease

Clinical Features for Nail Disease

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Drugs & Therapeutics for Nail Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nail Disease

Drug clinical trials:

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Search NIH Clinical Center for Nail Disease

Search CenterWatch for Nail Disease

Genetic Tests for Nail Disease

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Anatomical Context for Nail Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Nail Disease:

32
Skin, Kidney, Lung, Liver, Heart, Bone, Small intestine

FMA organs/tissues related to Nail Disease:

14
Nail

Animal Models for Nail Disease or affiliated genes

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Publications for Nail Disease

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Sources:
50PubMed
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Articles related to Nail Disease:

(show top 50)    (show all 86)
idTitleAuthorsYear
1
Nail shedding following hand, foot and mouth disease. (23723335)
2013
2
Quiz page December 2013: Hypoplastic nails, bowed elbows, and nephrotic syndrome. Nail-patella syndrome (hereditary osteo-onychodysplasia, Turner-Keiser syndrome, Fong disease). (24267390)
2013
3
Metoprolol-induced psoriatic nail disease. (22724586)
2013
4
Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis. (22337245)
2012
5
Yellow nail syndrome: nail change reflects disease severity. (22008009)
2012
6
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. (22156725)
2012
7
New concepts in median nail dystrophy, onychomycosis, and hand, foot, and mouth disease nail pathology. (22462009)
2012
8
Optical coherence tomography: a new tool to assess nail disease in psoriasis? (21791896)
2011
9
Measures of psoriatic arthritis: Tender and Swollen Joint Assessment, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Modified Nail Psoriasis Severity Index (mNAPSI), Mander/Newcastle Enthesitis Index (MEI), Leeds Enthesitis Index (LEI), Spondyloarthritis Research Consortium of Canada (SPARCC), Maastricht Ankylosing Spondylitis Enthesis Score (MASES), Leeds Dactylitis Index (LDI), Patient Global for Psoriatic Arthritis, Dermatology Life Quality Index (DLQI), Psoriatic Arthritis Quality of Life (PsAQOL), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Psoriatic Arthritis Response Criteria (PsARC), Psoriatic Arthritis Joint Activity Index (PsAJAI), Disease Activity in Psoriatic Arthritis (DAPSA), and Composite Psoriatic Disease Activity Index (CPDAI). (22588772)
2011
10
Nutrition and nail disease. (20620759)
2010
11
A case of rheumatoid arthritis with bucillamine-induced yellow nail syndrome initially manifesting as pulmonary disease. (21769257)
2010
12
Psoriatic nail disease: quality of life and treatment. (19799826)
2009
13
Nail disease in pemphigus vulgaris. (19903430)
2009
14
Clinical practice. Fungal nail disease. (19439745)
2009
15
Kidney disease in nail-patella syndrome. (18535845)
2009
16
Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. (19686380)
2009
17
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? (19424069)
2009
18
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. (18083272)
2008
19
Gene symbol: LMX1B. Disease: Nail-patella syndrome. (18846612)
2008
20
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? (16546613)
2006
21
Therapies for psoriatic nail disease. A systematic review. (16724366)
2006
22
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. (16673801)
2006
23
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. (18360572)
2005
24
Yellow nail syndrome in rheumatoid arthritis: a drug-induced disease? (15293107)
2004
25
Molecular genetics of hereditary hair and nail disease. (15468149)
2004
26
One interpretation of a psychometric study of patients with nail disease. (12664041)
2003
27
Observer agreement in recording the clinical signs of nail disease and the accuracy of a clinical diagnosis of fungal and non-fungal nail disease. (12653750)
2003
28
Yellow nail syndrome or diffuse lymphatic network disease. (12587788)
2002
29
Insight into podocyte differentiation from the study of human genetic disease: nail-patella syndrome and transcriptional regulation in podocytes. (11978876)
2002
30
Nails in the coffin: increasing evidence for the role of rheumatic disease in the cardiovascular mortality of rheumatoid arthritis. (11762929)
2001
31
Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome. (11175791)
2001
32
Nail disease: antifungals have similar cure rates, different side-effects. (10570567)
1999
33
Pigmented nails and Strongyloides stercoralis infestation causing clinical worsening in a patient treated for immunoproliferative small intestinal disease: two unusual observations. (10892497)
1999
34
Manual of nail disease and surgery (9767626)
1998
35
Yellow nail syndrome and bilateral cystic lung disease. (9888218)
1998
36
Pediatric nail disease. (7742236)
1995
37
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology). (7496239)
1995
38
Oral therapeutic agents in fungal nail disease. (8077514)
1994
39
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. (1381758)
1992
40
The spectrum of nail disease in patients with human immunodeficiency virus infection. (1619083)
1992
41
A systematic approach to examining the patient with nail disease. (2650839)
1989
42
Candida onychomycosis--an evaluation of the role of Candida species in nail disease. (3342176)
1988
43
Yellow nail syndrome and acquired immunodeficiency disease. (3454162)
1986
44
Yellow nail syndrome in patients with acquired immunodeficiency disease. (4078068)
1985
45
Toe nail disease secondary to poorly fitting shoes or abnormal biomechanics. (4064760)
1985
46
Letterer-Siwe disease with nail involvement. (6851645)
1983
47
Renal disease in nail-patella syndrome: clinical and morphologic studies. (4571998)
1972
48
Determination of acidic glycosaminoglycans (mucopolysaccharides) in urine by an ion exchange method. Application to "collagenoses", gargoylism, the nail-patella syndrome and Farber's disease. (4226725)
1967
49
THE ROLE OF PSEUDOMONAS AERUGINOSA IN NAIL DISEASE. (14043007)
1963
50
"Base coat" nail disease. Report of a case. (14788850)
1950

Genetic Variations for Nail Disease

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Expression for genes affiliated with Nail Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nail Disease

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Pathways for genes affiliated with Nail Disease

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Sources:
53Reactome
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Pathways related to Nail Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.3CEP76, ESCO1, SEH1L, TUBB6

Compounds for genes affiliated with Nail Disease

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GO Terms for genes affiliated with Nail Disease

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16Gene Ontology
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Biological processes related to Nail Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycleGO:0002788.7CEP76, ESCO1, SEH1L

Products for genes affiliated with Nail Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nail Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet