MCID: NLD001
MIFTS: 27

Nail Disease malady

Skin category

Summaries for Nail Disease

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards: Nail Disease, also known as nail diseases, is related to psoriatic arthritis and arthritis. An important gene associated with Nail Disease is PLCD1 (phospholipase C, delta 1), and among its related pathways is Cell Cycle. Affiliated tissues include nail.

Disease Ontology:8 An integumentary system disease that is located in nail.

Wikipedia:64 Nail diseases are distinct from diseases of the skin. Although nails are a skin appendage, they have... more...

Aliases & Classifications for Nail Disease

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Related Diseases for Nail Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nail Disease family:

nail disorder, nonsyndromic congenital, 10, nail disorder, nonsyndromic congenital, 9

Diseases related to Nail Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis10.3
2arthritis10.3
3anonychia congenita10.0RSPO4
4paronychia9.9
5pemphigus9.9
6bone development disease9.9
7pemphigus vulgaris9.9
8nutrition disease9.9

Graphical network of diseases related to Nail Disease:



Diseases related to nail disease

Clinical Features for Nail Disease

Drugs & Therapeutics for Nail Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nail Disease

Drug clinical trials:

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Search NIH Clinical Center for Nail Disease

Search CenterWatch for Nail Disease

Genetic Tests for Nail Disease

Anatomical Context for Nail Disease

Sources:
14FMA
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FMA organs/tissues related to Nail Disease:

14
Nail

Animal Models for Nail Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Nail Disease

Sources:
51PubMed
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Articles related to Nail Disease:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Half-and-half nail in BehAset's disease. (23452026)
2014
2
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. (23988587)
2013
3
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. (23423871)
2013
4
Quiz page December 2013: Hypoplastic nails, bowed elbows, and nephrotic syndrome. Nail-patella syndrome (hereditary osteo-onychodysplasia, Turner-Keiser syndrome, Fong disease). (24267390)
2013
5
Metoprolol-induced psoriatic nail disease. (22724586)
2013
6
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. (22383354)
2012
7
Yellow nail syndrome: nail change reflects disease severity. (22008009)
2012
8
Scleroderma pattern of nailfold capillary changes as predictive value for the development of a connective tissue disease: a follow-up study of 3,029 patients with primary Raynaud's phenomenon. (21901350)
2012
9
Measures of psoriatic arthritis: Tender and Swollen Joint Assessment, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Modified Nail Psoriasis Severity Index (mNAPSI), Mander/Newcastle Enthesitis Index (MEI), Leeds Enthesitis Index (LEI), Spondyloarthritis Research Consortium of Canada (SPARCC), Maastricht Ankylosing Spondylitis Enthesis Score (MASES), Leeds Dactylitis Index (LDI), Patient Global for Psoriatic Arthritis, Dermatology Life Quality Index (DLQI), Psoriatic Arthritis Quality of Life (PsAQOL), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Psoriatic Arthritis Response Criteria (PsARC), Psoriatic Arthritis Joint Activity Index (PsAJAI), Disease Activity in Psoriatic Arthritis (DAPSA), and Composite Psoriatic Disease Activity Index (CPDAI). (22588772)
2011
10
Nailfold capillary density is importantly associated over time with muscle and skin disease activity in juvenile dermatomyositis. (21156669)
2011
11
Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease. (20803293)
2011
12
Nutrition and nail disease. (20620759)
2010
13
A case of rheumatoid arthritis with bucillamine-induced yellow nail syndrome initially manifesting as pulmonary disease. (21769257)
2010
14
Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in systemic lupus erythematosus patients. (19907914)
2010
15
Psoriatic nail disease: quality of life and treatment. (19799826)
2009
16
Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. (19686380)
2009
17
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. (18083272)
2008
18
Gene symbol: LMX1B. Disease: Nail-patella syndrome. (18846612)
2008
19
Vascular endothelial growth factor in systemic lupus erythematosus: relationship to disease activity, systemic organ manifestation, and nailfold capillaroscopic abnormalities. (17557150)
2007
20
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? (16546613)
2006
21
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. (16673801)
2006
22
Phenotype severity and genetic variation at the disease locus: an investigation of nail dysplasia in the nail patella syndrome. (15638822)
2005
23
Alefacept in the treatment of psoriatic nail disease: a small case series. (15928640)
2005
24
Aspects of nailfold capillaroscopy in children and young people with rheumatic disease. (15529611)
2004
25
Molecular genetics of hereditary hair and nail disease. (15468149)
2004
26
Insight into podocyte differentiation from the study of human genetic disease: nail-patella syndrome and transcriptional regulation in podocytes. (11978876)
2002
27
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. (11501665)
2001
28
Nail matrix arrest in the course of hand, foot and mouth disease. (11760019)
2001
29
Psoriatic arthritis, nail disease and pustules following Hodgkin's lymphoma. (10952760)
2000
30
Pigmented nails and Strongyloides stercoralis infestation causing clinical worsening in a patient treated for immunoproliferative small intestinal disease: two unusual observations. (10892497)
1999
31
Manual of nail disease and surgery (9767626)
1998
32
Yellow nail syndrome and bilateral cystic lung disease. (9888218)
1998
33
Itraconazole now indicated to treat fungal nail disease. (11361668)
1996
34
Pediatric nail disease. (7742236)
1995
35
Oral therapeutic agents in fungal nail disease. (8077514)
1994
36
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. (1381758)
1992
37
Nailfold capillary density as a possible indicator of pulmonary capillary loss in systemic lupus erythematosus but not in mixed connective tissue disease. (1765978)
1991
38
A systematic approach to examining the patient with nail disease. (2650839)
1989
39
Hand, foot and nail disease--a common manifestation of chronic dermatophytosis. (3231234)
1988
40
Candida onychomycosis--an evaluation of the role of Candida species in nail disease. (3342176)
1988
41
Vasculitis and renal disease in nail-patella syndrome: case report and literature review. (3662646)
1987
42
Nail dystrophy in dyskeratosis congenita and chronic graft-vs-host disease. (3707164)
1986
43
Urea plaster for softening diseased nails in the treatment of tinea unguium. (2962190)
1986
44
Nailfold capillary microscopy in mixed connective tissue disease. Comparison with systemic sclerosis and systemic lupus erythematosus. (3954804)
1986
45
Yellow nail syndrome in patients with acquired immunodeficiency disease. (4078068)
1985
46
Toe nail disease secondary to poorly fitting shoes or abnormal biomechanics. (4064760)
1985
47
Letterer-Siwe disease with nail involvement. (6851645)
1983
48
Renal disease in nail-patella syndrome: clinical and morphologic studies. (4571998)
1972
49
Hereditary onycho-osteodysplasia (the nail-patella syndrome) with nephrosis-like renal disease in a newborn boy. (5423458)
1970
50
NAIL-PATELLA SYNDROME (ONYCHO-OSTEODYSPLASIA) WITH ASSOCIATED BOWEN'S DISEASE AND PAGET'S DISEASE OF BONE. (14068148)
1963

Genetic Variations for Nail Disease

Expression for genes affiliated with Nail Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Pathways for genes affiliated with Nail Disease

Sources:
54Reactome
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Pathways related to Nail Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.3CEP76, ESCO1, SEH1L, TUBB6

Compounds for genes affiliated with Nail Disease

GO Terms for genes affiliated with Nail Disease

Sources:
16Gene Ontology
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Biological processes related to Nail Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycleGO:0002788.7CEP76, ESCO1, SEH1L

Products for genes affiliated with Nail Disease

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  • Lysates
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Sources for Nail Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet