MCID: NLD001
MIFTS: 29

Nail Disease malady

Genetic diseases (common), Skin diseases categories

Summaries for Nail Disease

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MedlinePlus:32 Your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards based summary: Nail Disease, also known as nail diseases, is related to psoriatic arthritis and arthritis. An important gene associated with Nail Disease is RSPO4 (R-spondin 4), and among its related pathways are Signaling in Gap Junctions and Cell Cycle, Mitotic. Affiliated tissues include nail, skin and heart.

Disease Ontology:9 An integumentary system disease that is located in nail.

Wikipedia:63 Nail diseases are distinct from diseases of the skin. Although nails are a skin appendage, they have... more...

Aliases & Classifications for Nail Disease

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Related Diseases for Nail Disease

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Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 7 Nail Disorder, Nonsyndromic Congenital, 9
Nail Disorder, Nonsyndromic Congenital, 3, Nail Disorder, Nonsyndromic Congenital, 10,

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis10.3
2arthritis10.3
3psoriasis10.3
4pemphigus vulgaris9.9
5pemphigus9.9
6dermatophytosis9.9
7enthesopathy9.9
8blindness9.9

Graphical network of diseases related to Nail Disease:



Diseases related to nail disease

Symptoms for Nail Disease

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Drugs & Therapeutics for Nail Disease

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Drug clinical trials:

Search ClinicalTrials for Nail Disease

Search NIH Clinical Center for Nail Disease

Genetic Tests for Nail Disease

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Anatomical Context for Nail Disease

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MalaCards organs/tissues related to Nail Disease:

31
Skin, Heart, Kidney, Liver, Lung, Bone

FMA organs/tissues related to Nail Disease:

14
Nail

Animal Models for Nail Disease or affiliated genes

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Publications for Nail Disease

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Articles related to Nail Disease:

(show all 50)
idTitleAuthorsYear
1
Psoriatic nail disease, a predictor of psoriatic arthritis. (25409998)
2014
2
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. (23988587)
2013
3
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. (23423871)
2013
4
Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. (24117389)
2013
5
Drug-related nail disease. (24079591)
2013
6
Metoprolol-induced psoriatic nail disease. (22724586)
2013
7
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. (22383354)
2012
8
Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis. (22337245)
2012
9
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. (22156725)
2012
10
Assessment of psoriatic nail disease activity by rheumatologists: comment on the article by Lubrano et al. (22623218)
2012
11
Optical coherence tomography: a new tool to assess nail disease in psoriasis? (21791896)
2011
12
Nutrition and nail disease. (20620759)
2010
13
Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index. (21174373)
2010
14
Psoriatic nail disease: quality of life and treatment. (19799826)
2009
15
Nail disease in pemphigus vulgaris. (19903430)
2009
16
Clinical practice. Fungal nail disease. (19439745)
2009
17
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? (19424069)
2009
18
Management of psoriatic nail disease. (19341941)
2009
19
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. (18083272)
2008
20
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? (16546613)
2006
21
Therapies for psoriatic nail disease. A systematic review. (16724366)
2006
22
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. (16673801)
2006
23
Alefacept in the treatment of psoriatic nail disease: a small case series. (15928640)
2005
24
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. (18360572)
2005
25
Extended report: nail disease in psoriatic arthritis--clinically important, potentially treatable and often overlooked. (15113998)
2004
26
Molecular genetics of hereditary hair and nail disease. (15468149)
2004
27
One interpretation of a psychometric study of patients with nail disease. (12664041)
2003
28
Observer agreement in recording the clinical signs of nail disease and the accuracy of a clinical diagnosis of fungal and non-fungal nail disease. (12653750)
2003
29
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. (11501665)
2001
30
Psoriatic arthritis, nail disease and pustules following Hodgkin's lymphoma. (10952760)
2000
31
Nail disease: antifungals have similar cure rates, different side-effects. (10570567)
1999
32
Manual of nail disease and surgery (9767626)
1998
33
Itraconazole now indicated to treat fungal nail disease. (11361668)
1996
34
Pediatric nail disease. (7742236)
1995
35
The differential diagnosis of nail disease. (11361432)
1995
36
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology). (7496239)
1995
37
Oral therapeutic agents in fungal nail disease. (8077514)
1994
38
Lamisil -- A New Measure in Antifungal Therapy in Skin and Nail Disease. Proceedings of a symposium. Vienna, Austria, 18 May 1993. (7910478)
1994
39
Epidemiology of fungal skin and nail disease: roundtable discussion held at Dermatology 2000, Vienna, 17 May 1993. (8186144)
1994
40
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. (1381758)
1992
41
The spectrum of nail disease in patients with human immunodeficiency virus infection. (1619083)
1992
42
Single dose treatment of fungal nail disease. (1349100)
1992
43
Nail disease. (2018711)
1991
44
A systematic approach to examining the patient with nail disease. (2650839)
1989
45
Nail disease and dermatology. (2681287)
1989
46
Hand, foot and nail disease--a common manifestation of chronic dermatophytosis. (3231234)
1988
47
Candida onychomycosis--an evaluation of the role of Candida species in nail disease. (3342176)
1988
48
Toe nail disease secondary to poorly fitting shoes or abnormal biomechanics. (4064760)
1985
49
THE ROLE OF PSEUDOMONAS AERUGINOSA IN NAIL DISEASE. (14043007)
1963
50
"Base coat" nail disease. Report of a case. (14788850)
1950

Variations for Nail Disease

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Expression for genes affiliated with Nail Disease

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Search GEO for disease gene expression data for Nail Disease.

Pathways for genes affiliated with Nail Disease

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Pathways related to Nail Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PLCD1, TUBB6
2
Show member pathways
8.7CEP76, ESCO1, SEH1L

Compounds for genes affiliated with Nail Disease

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GO Terms for genes affiliated with Nail Disease

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Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycleGO:00002788.7CEP76, ESCO1, SEH1L

Products for genes affiliated with Nail Disease

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Nail Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet