MCID: NLD001
MIFTS: 54

Nail Disease malady

Categories: Skin diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Nail Disease

Summaries for Nail Disease

MedlinePlus : 41 your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards based summary : Nail Disease, also known as nail diseases, is related to paronychia and stenosis of lacrimal punctum, and has symptoms including exanthema, pruritus and clubbing of nail. An important gene associated with Nail Disease is RSPO4 (R-Spondin 4), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Phospholipase-C Pathway. The drugs Chlorhexidine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and heart, and related phenotypes are Decreased viability and integument

Disease Ontology : 12 An integumentary system disease that is located in nail.

Wikipedia : 71 A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

Related Diseases for Nail Disease

Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 3, Nail Disorder, Nonsyndromic Congenital, 10,
Nail Disorder, Nonsyndromic Congenital, 7 Nail Disorder, Nonsyndromic Congenital, 9
Nail Disorder, Nonsyndromic Congenital, 1 Nonsyndromic Congenital Nail Disorder 2
Nonsyndromic Congenital Nail Disorder 5 Nonsyndromic Congenital Nail Disorder 6

Diseases related to Nail Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 paronychia 10.7
2 stenosis of lacrimal punctum 10.1 EGFR HRAS
3 brown-vialetto-van laere syndrome 1 10.0 ESCO1 RSPO4 ZNF519
4 agenesis and aplasia of uterine body 10.0 EGFR KRAS
5 ureter adenocarcinoma 10.0 EGFR KRAS
6 malignant skin fibrous histiocytoma 10.0 HRAS KRAS
7 exudative glomerulonephritis 10.0 EGFR KRAS
8 chronic venous insufficiency 10.0 HRAS KRAS
9 erythrocyte lactate transporter defect 10.0 HRAS KRAS
10 melanocytic nevus syndrome, congenital, somatic 10.0 HRAS KRAS
11 postpoliomyelitis syndrome 10.0 HRAS KRAS
12 syndactyly-polydactyly-earlobe syndrome 10.0 HRAS KRAS
13 gonococcal seminal vesiculitis 10.0 HRAS KRAS
14 pelvic inflammatory disease 10.0 HRAS KRAS
15 cervical serous adenocarcinoma 10.0 HRAS KRAS
16 intermediate malignant teratoma 10.0 EGFR KRAS
17 breast mucinous cystadenocarcinoma 10.0 HRAS KRAS
18 uterine corpus endometrial stromal sarcoma 10.0 HRAS KRAS
19 psoriatic arthritis 9.9
20 arthritis 9.9
21 striated muscle rhabdoid tumor 9.9 HRAS KRAS
22 papillary adenofibroma 9.9 HRAS KRAS
23 bilateral hypoactive labyrinth 9.9 HRAS KRAS
24 tabes dorsalis 9.9 HRAS KRAS
25 ossifying fibromyxoid tumor 9.9 HRAS KRAS
26 aicardi-goutieres syndrome 9.9 HRAS KRAS
27 arthus reaction 9.9 HRAS KRAS
28 psoriasis 9.9
29 hyperproinsulinemia 9.9 HRAS KRAS
30 allergic contact dermatitis 9.9 EGFR KRAS
31 retina lymphoma 9.9 HRAS KRAS
32 plasmacytoma 9.8 HRAS KRAS
33 severe pre-eclampsia 9.8 EGFR HRAS KRAS
34 precursor t-lymphoblastic lymphoma/leukemia 9.8 EGFR HRAS KRAS
35 kidney clear cell sarcoma 9.8 EGFR HRAS KRAS
36 spongiotic dermatitis 9.8 EGFR HRAS KRAS
37 vascular hemostatic disease 9.8 EGFR HRAS KRAS
38 myxedema 9.8 EGFR HRAS KRAS
39 brachial plexus neuropathy 9.8 EGFR HRAS KRAS
40 multinodular goiter 9.8 EGFR HRAS KRAS
41 dental caries 9.8 EGFR HRAS KRAS
42 nasal cavity disease 9.8 EGFR HRAS KRAS
43 paroxysmal nocturnal hemoglobinuria 9.8 EGFR HRAS KRAS
44 spastic diplegia infantile type 9.8 EGFR KRAS
45 oral squamous cell carcinoma 9.8 EGFR HRAS KRAS
46 pearson syndrome 9.8 EGFR HRAS KRAS
47 trachea squamous cell carcinoma 9.8 EGFR HRAS KRAS
48 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 9.8 EGFR HRAS KRAS
49 non-distal monosomy 10q 9.8 EGFR HRAS KRAS
50 malignant pleural solitary fibrous tumor 9.8 EGFR HRAS KRAS

Graphical network of the top 20 diseases related to Nail Disease:



Diseases related to Nail Disease

Symptoms & Phenotypes for Nail Disease

UMLS symptoms related to Nail Disease:


exanthema, pruritus, clubbing of nail

GenomeRNAi Phenotypes related to Nail Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.77 HRAS KRAS EGFR
2 Decreased viability GR00106-A-0 9.77 KRAS
3 Decreased viability GR00221-A-1 9.77 KRAS EGFR HRAS
4 Decreased viability GR00221-A-2 9.77 KRAS HRAS
5 Decreased viability GR00221-A-3 9.77 HRAS
6 Decreased viability GR00221-A-4 9.77 EGFR
7 Decreased viability GR00301-A 9.77 KRAS
8 Decreased viability GR00381-A-1 9.77 KRAS
9 Increased cell migration GR00055-A-3 8.8 EGFR HRAS KRAS

MGI Mouse Phenotypes related to Nail Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 EGFR FZD6 HRAS KRAS PLCD1

Drugs & Therapeutics for Nail Disease

Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 245)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2
Ethanol Approved Phase 4,Phase 3 64-17-5 702
3
Phenol Approved, Experimental Phase 4 108-95-2 996
4
Ciclopirox Approved, Investigational Phase 4,Phase 3,Phase 2 29342-05-0 2749
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
6
Polidocanol Approved Phase 4 9002-92-0
7
Bifonazole Approved Phase 4,Phase 3 60628-96-8 2378
8
Terbinafine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 91161-71-6 5402 1549008
9
Lenograstim Approved Phase 4 135968-09-1
10
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
11
Etanercept Approved, Investigational Phase 4,Phase 3 185243-69-0
12
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
13
Ustekinumab Approved, Investigational Phase 4,Phase 3 815610-63-0
14
Ezogabine Approved Phase 4,Phase 3 150812-12-7 121892
15
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
16
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
17
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
18
Efinaconazole Approved Phase 4,Phase 3 164650-44-6
19 tannic acid Approved, Nutraceutical Phase 4,Phase 3
20
Docetaxel Approved May 1996, Investigational Phase 4,Phase 3 114977-28-5 148124 9877265
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Anti-Infective Agents, Local Phase 4
23 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
24 Chlorhexidine gluconate Phase 4
25 Dermatologic Agents Phase 4,Phase 2,Phase 3
26 Disinfectants Phase 4
27 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Amorolfine Phase 4,Phase 3,Phase 2,Phase 1
29 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 2
31 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
32 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
33 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Keratolytic Agents Phase 4,Phase 2,Phase 3
37 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
38 Adrenocorticotropic Hormone Phase 4
39 beta-endorphin Phase 4
40 Melanocyte-Stimulating Hormones Phase 4
41 Antirheumatic Agents Phase 4,Phase 3,Phase 2
42 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Adjuvants, Immunologic Phase 4
45 Antimitotic Agents Phase 4,Phase 3
46 Hydroxyitraconazole Phase 4,Phase 3,Phase 2
47 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
48 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
49 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 295)
id Name Status NCT ID Phase
1 Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy Unknown status NCT01844141 Phase 4
2 Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Unknown status NCT01014637 Phase 4
3 Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis Unknown status NCT02436291 Phase 4
4 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
5 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
6 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4
7 An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst Unknown status NCT02154789 Phase 4
8 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4
9 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4
10 Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish Completed NCT02321098 Phase 4
11 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% Completed NCT02705664 Phase 4
12 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer Completed NCT02679911 Phase 4
13 Topical Penlac Nail Lacquer for Onychomycosis in Children Completed NCT01419847 Phase 4
14 A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment Completed NCT02464826 Phase 4
15 Scoring Clinical Index For Onychomycosis in Toenail Onychomycosis Treating With Itraconazole Capsules Completed NCT00871728 Phase 4
16 Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis Completed NCT01851590 Phase 4
17 Proximal Femoral Nail Antirotation™ (PFNA) Versus Gamma Nail 3™ (Gamma3) for Intramedullary Nailing of Unstable Trochanteric Fractures Completed NCT00736684 Phase 4
18 Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis Completed NCT00581100 Phase 4
19 Evaluation of the Efficacy of Acitretin Therapy for Nail Psoriasis Completed NCT00723437 Phase 4
20 A Phase IV Clinical Trial to Study the Safety, Tolerability and Efficacy of Tinefcon in Patients With Plaque Psoriasis Completed NCT01373567 Phase 4
21 A Study to Evaluate Ustekinumab in Patients With Plaque Psoriasis in Asia-Pacific Countries Completed NCT01677598 Phase 4
22 An Open Label Study to Evaluate the Effects of Ezogabine/Retigabine Added to Existing Anti-epileptic Drug(s) on Urinary Voiding Function in Subjects With Partial Onset Seizures Completed NCT01607346 Phase 4
23 Controlled Study of Humira in Subjects With Chronic Plaque Psoriasis of the Hands and/or Feet Completed NCT00735787 Phase 4
24 An Open-Label, Prospective Study to Assess the Safety and Effectiveness of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in the Russian Federation Completed NCT01644396 Phase 4
25 Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis Recruiting NCT02812043 Phase 4
26 Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis Recruiting NCT02812771 Phase 4
27 Study Evaluating the Effect of Jublia on Dermatophytomas Active, not recruiting NCT03098615 Phase 4
28 Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish Active, not recruiting NCT03110029 Phase 4
29 An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Apremilast for the Treatment of Nail Psoriasis Not yet recruiting NCT03022617 Phase 4
30 A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis Not yet recruiting NCT03151551 Phase 4
31 Addition of Excimer Laser to Treatment With Acitretin Tablets for Psoriasis of the Palms and Soles Terminated NCT02181790 Phase 4
32 TDT 067 Onychomycosis Study Unknown status NCT01145807 Phase 3
33 Treating Onychomychosis Unknown status NCT00776464 Phase 2, Phase 3
34 Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females Unknown status NCT00856596 Phase 3
35 Evaluation of the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Breast or Prostate Cancer Completed NCT00925418 Phase 3
36 Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail. Completed NCT00356915 Phase 3
37 Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443820 Phase 3
38 Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443898 Phase 3
39 Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis Completed NCT00459537 Phase 3
40 Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste Completed NCT00781820 Phase 3
41 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3
42 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3
43 PinPointe FootLaser for the Treatment of Onychomycosis Completed NCT00935649 Phase 2, Phase 3
44 Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis Completed NCT01431820 Phase 2, Phase 3
45 Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01008033 Phase 3
46 The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01007708 Phase 3
47 Evaluation of the Efficacy and Safety of Indigo Naturalis Oil Extract on Psoriatic Nails Completed NCT00999687 Phase 2, Phase 3
48 Study to Evaluate the Efficacy and Safety of P-3073 Nail Solution in the Treatment of Nails Affected by Psoriasis Completed NCT02606760 Phase 3
49 A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis Completed NCT02016482 Phase 3
50 Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Nail Psoriasis Completed NCT01807520 Phase 3

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

Genetic Tests for Nail Disease

Genetic tests related to Nail Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Nail 29

Anatomical Context for Nail Disease

MalaCards organs/tissues related to Nail Disease:

39
Skin, Lung, Heart, Liver, Kidney, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Nail Disease:

18
Nail

Publications for Nail Disease

Articles related to Nail Disease:

(show top 50) (show all 53)
id Title Authors Year
1
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. ( 27932277 )
2016
2
Nail Disease for the Primary Care Provider. ( 26476249 )
2015
3
Ultrasound in the management of nail disease. ( 26895940 )
2015
4
Psoriatic nail disease, a predictor of psoriatic arthritis. ( 25409998 )
2014
5
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. ( 23423871 )
2013
6
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. ( 23988587 )
2013
7
Metoprolol-induced psoriatic nail disease. ( 22724586 )
2013
8
Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. ( 24117389 )
2013
9
Drug-related nail disease. ( 24079591 )
2013
10
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. ( 22156725 )
2012
11
Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis. ( 22337245 )
2012
12
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. ( 22383354 )
2012
13
Assessment of psoriatic nail disease activity by rheumatologists: comment on the article by Lubrano et al. ( 22623218 )
2012
14
Optical coherence tomography: a new tool to assess nail disease in psoriasis? ( 21791896 )
2011
15
Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index. ( 21174373 )
2010
16
Nutrition and nail disease. ( 20620759 )
2010
17
Psoriatic nail disease: quality of life and treatment. ( 19799826 )
2009
18
Clinical practice. Fungal nail disease. ( 19439745 )
2009
19
Management of psoriatic nail disease. ( 19341941 )
2009
20
Nail disease in pemphigus vulgaris. ( 19903430 )
2009
21
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? ( 19424069 )
2009
22
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. ( 18083272 )
2008
23
Therapies for psoriatic nail disease. A systematic review. ( 16724366 )
2006
24
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? ( 16546613 )
2006
25
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. ( 16673801 )
2006
26
Alefacept in the treatment of psoriatic nail disease: a small case series. ( 15928640 )
2005
27
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. ( 18360572 )
2005
28
Molecular genetics of hereditary hair and nail disease. ( 15468149 )
2004
29
Extended report: nail disease in psoriatic arthritis--clinically important, potentially treatable and often overlooked. ( 15113998 )
2004
30
One interpretation of a psychometric study of patients with nail disease. ( 12664041 )
2003
31
Observer agreement in recording the clinical signs of nail disease and the accuracy of a clinical diagnosis of fungal and non-fungal nail disease. ( 12653750 )
2003
32
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. ( 11501665 )
2001
33
Psoriatic arthritis, nail disease and pustules following Hodgkin's lymphoma. ( 10952760 )
2000
34
Nail disease: antifungals have similar cure rates, different side-effects. ( 10570567 )
1999
35
Manual of nail disease and surgery ( 9767626 )
1998
36
Itraconazole now indicated to treat fungal nail disease. ( 11361668 )
1996
37
The differential diagnosis of nail disease. ( 11361432 )
1995
38
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology). ( 7496239 )
1995
39
Pediatric nail disease. ( 7742236 )
1995
40
Lamisil -- A New Measure in Antifungal Therapy in Skin and Nail Disease. Proceedings of a symposium. Vienna, Austria, 18 May 1993. ( 7910478 )
1994
41
Epidemiology of fungal skin and nail disease: roundtable discussion held at Dermatology 2000, Vienna, 17 May 1993. ( 8186144 )
1994
42
Oral therapeutic agents in fungal nail disease. ( 8077514 )
1994
43
The spectrum of nail disease in patients with human immunodeficiency virus infection. ( 1619083 )
1992
44
Single dose treatment of fungal nail disease. ( 1349100 )
1992
45
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. ( 1381758 )
1992
46
Nail disease. ( 2018711 )
1991
47
Nail disease and dermatology. ( 2681287 )
1989
48
A systematic approach to examining the patient with nail disease. ( 2650839 )
1989
49
Candida onychomycosis--an evaluation of the role of Candida species in nail disease. ( 3342176 )
1988
50
Hand, foot and nail disease--a common manifestation of chronic dermatophytosis. ( 3231234 )
1988

Variations for Nail Disease

ClinVar genetic disease variations for Nail Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FZD6 NM_003506.3(FZD6): c.1750G> T (p.Glu584Ter) single nucleotide variant Pathogenic rs151339002 GRCh37 Chromosome 8, 104342091: 104342091
2 FZD6 NM_003506.3(FZD6): c.1531C> T (p.Arg511Cys) single nucleotide variant Pathogenic rs151339003 GRCh37 Chromosome 8, 104340634: 104340634

Expression for Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Pathways for Nail Disease

Pathways related to Nail Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 EGFR FZD6 HRAS KRAS PLCD1
2
Show member pathways
12.91 EGFR HRAS KRAS PLCD1
3
Show member pathways
12.87 EGFR FZD6 HRAS KRAS
4
Show member pathways
12.73 EGFR HRAS KRAS PLCD1
5
Show member pathways
12.7 EGFR HRAS KRAS PLCD1
6 12.46 EGFR FZD6 HRAS KRAS
7
Show member pathways
12.44 EGFR HRAS KRAS PLCD1
8 12.38 EGFR HRAS KRAS
9
Show member pathways
12.32 EGFR HRAS KRAS
10 12.3 FZD6 HRAS KRAS
11
Show member pathways
12.3 EGFR HRAS KRAS
12
Show member pathways
12.28 EGFR HRAS KRAS
13
Show member pathways
12.27 EGFR HRAS PLCD1
14
Show member pathways
12.24 EGFR HRAS KRAS
15
Show member pathways
12.23 FZD6 HRAS KRAS
16
Show member pathways
12.22 EGFR HRAS KRAS
17
Show member pathways
12.18 EGFR HRAS KRAS
18
Show member pathways
12.16 EGFR HRAS KRAS
19
Show member pathways
12.15 EGFR HRAS KRAS PLCD1
20
Show member pathways
12.09 EGFR HRAS KRAS
21 12.04 EGFR FZD6 KRAS
22 12.04 EGFR HRAS KRAS
23
Show member pathways
12 EGFR HRAS KRAS
24
Show member pathways
11.98 EGFR FZD6 HRAS
25 11.98 EGFR FZD6 HRAS KRAS
26
Show member pathways
11.95 EGFR HRAS KRAS
27 11.94 FZD6 HRAS KRAS
28
Show member pathways
11.93 EGFR HRAS KRAS
29
Show member pathways
11.9 EGFR HRAS KRAS
30 11.89 EGFR HRAS KRAS
31 11.85 FZD6 HRAS KRAS
32 11.82 HRAS KRAS PLCD1
33
Show member pathways
11.82 EGFR FZD6 HRAS KRAS RSPO4
34
Show member pathways
11.77 EGFR HRAS KRAS
35 11.71 HRAS KRAS PLCD1
36
Show member pathways
11.66 EGFR HRAS KRAS
37 11.63 EGFR HRAS KRAS
38 11.59 EGFR HRAS KRAS
39 11.53 EGFR HRAS KRAS
40 11.47 EGFR HRAS KRAS
41 11.36 EGFR HRAS KRAS
42 11.26 EGFR HRAS KRAS
43 11.24 HRAS KRAS
44 11.19 EGFR HRAS
45
Show member pathways
11.19 FZD6 RSPO4
46 11.17 HRAS KRAS
47
Show member pathways
11.16 HRAS KRAS
48 11.15 HRAS KRAS
49 11.13 EGFR KRAS
50 11.11 EGFR KRAS

GO Terms for Nail Disease

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.63 EGFR FZD6 HRAS
2 MAPK cascade GO:0000165 9.58 EGFR HRAS KRAS
3 positive regulation of protein phosphorylation GO:0001934 9.5 EGFR HRAS KRAS
4 positive regulation of DNA replication GO:0045740 9.48 EGFR HRAS
5 hair follicle development GO:0001942 9.43 EGFR FZD6
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 HRAS KRAS
7 positive regulation of MAP kinase activity GO:0043406 9.33 EGFR HRAS KRAS
8 response to isolation stress GO:0035900 9.26 HRAS KRAS
9 epidermal growth factor receptor signaling pathway GO:0007173 9.13 EGFR HRAS KRAS
10 ERBB2 signaling pathway GO:0038128 8.8 EGFR HRAS KRAS

Sources for Nail Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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