MCID: NLD001
MIFTS: 47

Nail Disease

Categories: Skin diseases, Rare diseases, Genetic diseases, Fetal diseases

Aliases & Classifications for Nail Disease

Summaries for Nail Disease

MedlinePlus : 40 Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. The health of your nails can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless. Nail problems that sometimes require treatment include Bacterial and fungal infections Ingrown nails Tumors Warts Keeping your nails clean, dry, and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.

MalaCards based summary : Nail Disease, also known as nail diseases, is related to nail-patella syndrome and paronychia, and has symptoms including clubbing of nail, pruritus and exanthema. An important gene associated with Nail Disease is FZD6 (Frizzled Class Receptor 6), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Gap junction. The drugs Chlorhexidine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include nail, skin and lung.

Disease Ontology : 12 An integumentary system disease that is located in nail.

Wikipedia : 72 A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure... more...

Related Diseases for Nail Disease

Graphical network of the top 20 diseases related to Nail Disease:



Diseases related to Nail Disease

Symptoms & Phenotypes for Nail Disease

UMLS symptoms related to Nail Disease:


clubbing of nail, pruritus, exanthema

Drugs & Therapeutics for Nail Disease

Drugs for Nail Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
2
Ethanol Approved Phase 4 64-17-5 702
3
Phenol Approved, Experimental Phase 4 108-95-2 996
4
Ciclopirox Approved, Investigational Phase 4,Phase 3,Phase 2 29342-05-0 2749
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
6
Bifonazole Approved, Investigational Phase 4,Phase 3 60628-96-8 2378
7
Terbinafine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 91161-71-6 1549008 5402
8
Lenograstim Approved, Investigational Phase 4 135968-09-1
9
Tavaborole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 174671-46-6
10
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
11
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
12
Efinaconazole Approved Phase 4,Phase 3 164650-44-6
13
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
15
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
16
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
17
Docetaxel Approved May 1996, Investigational Phase 4,Phase 3 114977-28-5 148124 9877265
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Anti-Infective Agents, Local Phase 4
20 Central Nervous System Depressants Phase 4
21 Chlorhexidine gluconate Phase 4
22 Dermatologic Agents Phase 4,Phase 2
23 Disinfectants Phase 4
24 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
25 Amorolfine Phase 4,Phase 3,Phase 2,Phase 1
26 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2
28 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
29 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
31 Hormones Phase 4,Phase 3,Phase 2,Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
33 Keratolytic Agents Phase 4
34 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 Peripheral Nervous System Agents Phase 4,Phase 2
36 Polyhexamethylene biguanide Phase 4
37 Adjuvants, Immunologic Phase 4
38 Antimitotic Agents Phase 4,Phase 3
39 Hydroxyitraconazole Phase 4,Phase 3,Phase 2
40 Analgesics Phase 4,Phase 2
41 Analgesics, Non-Narcotic Phase 4,Phase 2
42 Anti-Inflammatory Agents Phase 4,Phase 2
43 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
44 Antirheumatic Agents Phase 4,Phase 2
45 Micronutrients Phase 4
46 Nicotinic Acids Phase 4
47 Trace Elements Phase 4
48 Vitamin B Complex Phase 4
49 Vitamins Phase 4
50 Folate Nutraceutical Phase 4

Interventional clinical trials:

(show top 50) (show all 134)

# Name Status NCT ID Phase Drugs
1 Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy Unknown status NCT01844141 Phase 4 70% alcohol;70% alcohol - 0.5% clorhexidine
2 Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
3 Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis Unknown status NCT02436291 Phase 4
4 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4 Polihexanide
5 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
6 An Evaluation of the Safety and Pharmacokinetics of Tavaborole Topical Solution for the Treatment of Fungal Disease of the Toenail in Children and Adolescents Completed NCT03405818 Phase 4 Tavaborole 5% Topical Solution
7 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% Completed NCT02705664 Phase 4 Loceryl Nail Lacquer;Urea Ointment;Bifonazole Cream
8 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer Completed NCT02679911 Phase 4 Loceryl Nail Lacquer;Ciclopirox Nail Lacquer
9 A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment Completed NCT02464826 Phase 4 Nailprotex
10 Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish Completed NCT02321098 Phase 4 Loceryl Nail Lacquer;Loceryl Nail Lacquer;Loceryl Nail Lacquer follow up period
11 Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis Completed NCT01851590 Phase 4 Amorolfine;Terbinafine
12 Topical Penlac Nail Lacquer for Onychomycosis in Children Completed NCT01419847 Phase 4 Ciclopirox;Placebo
13 Scoring Clinical Index For Onychomycosis in Toenail Onychomycosis Treating With Itraconazole Capsules Completed NCT00871728 Phase 4 Itraconazole
14 Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis Recruiting NCT02812771 Phase 4 Efinaconazole
15 Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis Recruiting NCT02812043 Phase 4 Amorolfine
16 Study Evaluating the Effect of Jublia on Dermatophytomas Active, not recruiting NCT03098615 Phase 4 Jublia (Efinaconazole 10% Topical Solution)
17 Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish Active, not recruiting NCT03110029 Phase 4 Efinaconazole 10% (Jublia)
18 An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Apremilast for the Treatment of Nail Psoriasis Enrolling by invitation NCT03022617 Phase 4 Apremilast
19 Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic Nail Disease Not yet recruiting NCT03263624 Phase 4 Tazarotene Cream 0.1%
20 Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis Not yet recruiting NCT03280927 Phase 4 Jublia®
21 TDT 067 Onychomycosis Study Unknown status NCT01145807 Phase 3 TDT067;Placebo;Transfersome
22 Treating Onychomychosis Unknown status NCT00776464 Phase 2, Phase 3
23 Evaluation of the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Breast or Prostate Cancer Completed NCT00925418 Phase 3
24 Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail. Completed NCT00356915 Phase 3 Itraconazole 100mg capsules;Itraconazole 200mg tablets;Placebo tablets
25 Clinical Trial on Onychomycosis With P-3058 Nail Solution in Pediatric Population Completed NCT02547701 Phase 3 P-3058
26 Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis Completed NCT01431820 Phase 2, Phase 3 Luliconazole Solution, 10%;Vehicle Solution
27 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
28 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
29 Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01008033 Phase 3 IDP-108;Vehicle
30 The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01007708 Phase 3 IDP-108;Vehicle
31 PinPointe FootLaser for the Treatment of Onychomycosis Completed NCT00935649 Phase 2, Phase 3
32 Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste Completed NCT00781820 Phase 3 Bifonazole cream 1%;Placebo cream
33 Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis Completed NCT00459537 Phase 3 terbinafine hydrogen chloride;amorolfine nail lacquer
34 Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443898 Phase 3 terbinafine;Placebo;terbinafine;Placebo
35 Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443820 Phase 3 terbinafine;Placebo;terbinafine;Placebo
36 Efficacy and Safety of Efinaconazole 10% Solution in the Treatment of Onychomycosis in Diabetic Patients Recruiting NCT03168841 Phase 3 Efinaconazole Topical
37 Study to Evaluate the Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Recruiting NCT02866032 Phase 3 MOB015B;Ciclopirox 80 mg/g
38 A Multi-centre, Double-blind, Randomized, Vehicle-controlled Study of Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Recruiting NCT02859519 Phase 3 MOB015B;MOB015B Vehicle
39 Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Toenail Onychomycosis Active, not recruiting NCT02549001 Phase 3 P-3058 10%;vehicle of P-3058 10%;amorolfine 5%
40 Antifungal Drugs in Treatment of Onychomycosis Not yet recruiting NCT03171584 Phase 3 Terbinafine
41 Study Efficacy and Safety in Comparative Use of Investigational Product Adjuvant Treatment in Onychomycosis Not yet recruiting NCT02961634 Phase 3 Ciclopirox 8%
42 Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails Terminated NCT01208168 Phase 3 NAB001;Vehicle alone
43 Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails Terminated NCT01208129 Phase 3 NAB001;Placebo control
44 Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis Withdrawn NCT03094468 Phase 3 P-3058 (terbinafine hydrochloride 10%);Vehicle of P-3058
45 Erbium-doped Yttrium Aluminium Garnet Laser(Er:Yag)Associated With Amorolfine Lacquer in the Treatment of Onychomycosis Unknown status NCT01528813 Phase 2 Amorolfine lacquer
46 Using Light Therapy to Treat Toe Nail Fungus Unknown status NCT00771732 Phase 2
47 Botulinumtoxin A Treatment in Epidermolysis Bullosa Simplex and Pachyonychia Congenita Unknown status NCT00936533 Phase 2 Dysport® (Botulinumtoxin A (Btx A));Placebo
48 A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail Unknown status NCT00385502 Phase 2 EcoNail™ (econazole 5%/SEPA® 18% nail lacquer)
49 Restasis for Treatment of Brittle Nails Completed NCT00986427 Phase 2 Restasis (cyclosporine ophthalmic emulsion) 0.05%;Refresh® Dry Eye therapy
50 Safety and Efficacy of NVXT Solution in Mild-to-Moderate Fungal Infection of the Toe Nail Completed NCT02343627 Phase 2 NVXT Solution;Vehicle of test product

Search NIH Clinical Center for Nail Disease

Cochrane evidence based reviews: nail diseases

Genetic Tests for Nail Disease

Genetic tests related to Nail Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Nail 28

Anatomical Context for Nail Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Nail Disease:

18
Nail

MalaCards organs/tissues related to Nail Disease:

38
Skin, Lung, Kidney, Liver, Heart, Testes, Prostate

Publications for Nail Disease

Articles related to Nail Disease:

(show top 50) (show all 58)
# Title Authors Year
1
The microbial flora of taxane therapy-associated nail disease in cancer patients. ( 29447679 )
2018
2
Rare Variant of Ankyloblepharon-ectodermal Defect-cleft Lip/Cleft Palate Syndrome: Curly Hair-ankyloblepharon-nail Disease Syndrome. ( 29440852 )
2018
3
Reply to: "The microbial flora of taxane therapy-associated nail disease in cancer patients". ( 29447686 )
2018
4
Biotin for the treatment of nail disease: what is the evidence? ( 29057689 )
2017
5
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. ( 27932277 )
2016
6
Optimal management of nail disease in patients with psoriasis. ( 29387579 )
2015
7
Ultrasound in the management of nail disease. ( 26895940 )
2015
8
Nail Disease for the Primary Care Provider. ( 26476249 )
2015
9
Psoriatic nail disease, a predictor of psoriatic arthritis. ( 25409998 )
2014
10
Metoprolol-induced psoriatic nail disease. ( 22724586 )
2013
11
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. ( 23423871 )
2013
12
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. ( 23988587 )
2013
13
Drug-related nail disease. ( 24079591 )
2013
14
Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. ( 24117389 )
2013
15
Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis. ( 22337245 )
2012
16
Assessment of psoriatic nail disease activity by rheumatologists: comment on the article by Lubrano et al. ( 22623218 )
2012
17
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. ( 22156725 )
2012
18
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. ( 22383354 )
2012
19
Optical coherence tomography: a new tool to assess nail disease in psoriasis? ( 21791896 )
2011
20
Nutrition and nail disease. ( 20620759 )
2010
21
Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index. ( 21174373 )
2010
22
Psoriatic nail disease: quality of life and treatment. ( 19799826 )
2009
23
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? ( 19424069 )
2009
24
Nail disease in pemphigus vulgaris. ( 19903430 )
2009
25
Management of psoriatic nail disease. ( 19341941 )
2009
26
Clinical practice. Fungal nail disease. ( 19439745 )
2009
27
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. ( 18083272 )
2008
28
Therapies for psoriatic nail disease. A systematic review. ( 16724366 )
2006
29
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? ( 16546613 )
2006
30
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. ( 16673801 )
2006
31
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. ( 18360572 )
2005
32
Alefacept in the treatment of psoriatic nail disease: a small case series. ( 15928640 )
2005
33
Molecular genetics of hereditary hair and nail disease. ( 15468149 )
2004
34
Extended report: nail disease in psoriatic arthritis--clinically important, potentially treatable and often overlooked. ( 15113998 )
2004
35
One interpretation of a psychometric study of patients with nail disease. ( 12664041 )
2003
36
Observer agreement in recording the clinical signs of nail disease and the accuracy of a clinical diagnosis of fungal and non-fungal nail disease. ( 12653750 )
2003
37
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. ( 11501665 )
2001
38
Psoriatic arthritis, nail disease and pustules following Hodgkin's lymphoma. ( 10952760 )
2000
39
Nail disease: antifungals have similar cure rates, different side-effects. ( 10570567 )
1999
40
Manual of nail disease and surgery ( 9767626 )
1998
41
Itraconazole now indicated to treat fungal nail disease. ( 11361668 )
1996
42
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology). ( 7496239 )
1995
43
The differential diagnosis of nail disease. ( 11361432 )
1995
44
Pediatric nail disease. ( 7742236 )
1995
45
Epidemiology of fungal skin and nail disease: roundtable discussion held at Dermatology 2000, Vienna, 17 May 1993. ( 8186144 )
1994
46
Oral therapeutic agents in fungal nail disease. ( 8077514 )
1994
47
Lamisil -- A New Measure in Antifungal Therapy in Skin and Nail Disease. Proceedings of a symposium. Vienna, Austria, 18 May 1993. ( 7910478 )
1994
48
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. ( 1381758 )
1992
49
Single dose treatment of fungal nail disease. ( 1349100 )
1992
50
The spectrum of nail disease in patients with human immunodeficiency virus infection. ( 1619083 )
1992

Variations for Nail Disease

ClinVar genetic disease variations for Nail Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FZD6 NM_003506.3(FZD6): c.1750G> T (p.Glu584Ter) single nucleotide variant Pathogenic rs151339002 GRCh37 Chromosome 8, 104342091: 104342091
2 FZD6 NM_003506.3(FZD6): c.1531C> T (p.Arg511Cys) single nucleotide variant Pathogenic rs151339003 GRCh37 Chromosome 8, 104340634: 104340634

Expression for Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Pathways for Nail Disease

Pathways related to Nail Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 EGFR FZD6 RSPO4
2 11.27 EGFR TUBB6
3 11.09 EGFR FZD6
4 10.84 EGFR FZD6 PLCD1
5
Show member pathways
10.45 FZD6 RSPO4

GO Terms for Nail Disease

Biological processes related to Nail Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hair follicle development GO:0001942 8.62 EGFR FZD6

Molecular functions related to Nail Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 8.8 EGFR FZD6 PLCD1

Sources for Nail Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....