MCID: NLD001
MIFTS: 34

Nail Disease malady

Genetic diseases, Skin diseases, Rare diseases categories
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Summaries for Nail Disease

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards: Nail Disease, also known as nail diseases, is related to psoriatic arthritis and arthritis. An important gene associated with Nail Disease is RSPO4 (R-spondin 4), and among its related pathways are Signaling in Gap Junctions and Cell Cycle, Mitotic. Affiliated tissues include nail, skin and heart.

Disease Ontology:8 An integumentary system disease that is located in nail.

Wikipedia:65 Nail diseases are distinct from diseases of the skin. Although nails are a skin appendage, they have... more...

Aliases & Classifications for Nail Disease

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Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Nail Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 10, Nail Disorder, Nonsyndromic Congenital, 9

Diseases related to Nail Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis10.3
2arthritis10.3
3psoriasis10.3
4pemphigus9.8
5dermatophytosis9.8
6enthesopathy9.8
7hodgkin's lymphoma9.8
8pemphigus vulgaris9.8
9blindness9.8

Graphical network of diseases related to Nail Disease:



Diseases related to nail disease

Symptoms for Nail Disease

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Drugs & Therapeutics for Nail Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Nail Disease

Search NIH Clinical Center for Nail Disease

Genetic Tests for Nail Disease

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Anatomical Context for Nail Disease

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Nail Disease:

33
Skin, Heart, Kidney, Liver, Lung, Bone

FMA organs/tissues related to Nail Disease:

14
Nail

Animal Models for Nail Disease or affiliated genes

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Publications for Nail Disease

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Sources:
52PubMed
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Articles related to Nail Disease:

(show all 49)
idTitleAuthorsYear
1
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. (23988587)
2013
2
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. (23423871)
2013
3
Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. (24117389)
2013
4
Drug-related nail disease. (24079591)
2013
5
Metoprolol-induced psoriatic nail disease. (22724586)
2013
6
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. (22383354)
2012
7
Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis. (22337245)
2012
8
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. (22156725)
2012
9
Assessment of psoriatic nail disease activity by rheumatologists: comment on the article by Lubrano et al. (22623218)
2012
10
Optical coherence tomography: a new tool to assess nail disease in psoriasis? (21791896)
2011
11
Nutrition and nail disease. (20620759)
2010
12
Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index. (21174373)
2010
13
Psoriatic nail disease: quality of life and treatment. (19799826)
2009
14
Nail disease in pemphigus vulgaris. (19903430)
2009
15
Clinical practice. Fungal nail disease. (19439745)
2009
16
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? (19424069)
2009
17
Management of psoriatic nail disease. (19341941)
2009
18
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. (18083272)
2008
19
Alefacept treatment of psoriatic nail disease: how severe should nail psoriasis be? (16546613)
2006
20
Therapies for psoriatic nail disease. A systematic review. (16724366)
2006
21
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. (16673801)
2006
22
Alefacept in the treatment of psoriatic nail disease: a small case series. (15928640)
2005
23
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. (18360572)
2005
24
Extended report: nail disease in psoriatic arthritis--clinically important, potentially treatable and often overlooked. (15113998)
2004
25
Molecular genetics of hereditary hair and nail disease. (15468149)
2004
26
One interpretation of a psychometric study of patients with nail disease. (12664041)
2003
27
Observer agreement in recording the clinical signs of nail disease and the accuracy of a clinical diagnosis of fungal and non-fungal nail disease. (12653750)
2003
28
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. (11501665)
2001
29
Psoriatic arthritis, nail disease and pustules following Hodgkin's lymphoma. (10952760)
2000
30
Nail disease: antifungals have similar cure rates, different side-effects. (10570567)
1999
31
Manual of nail disease and surgery (9767626)
1998
32
Itraconazole now indicated to treat fungal nail disease. (11361668)
1996
33
Pediatric nail disease. (7742236)
1995
34
The differential diagnosis of nail disease. (11361432)
1995
35
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology). (7496239)
1995
36
Oral therapeutic agents in fungal nail disease. (8077514)
1994
37
Lamisil -- A New Measure in Antifungal Therapy in Skin and Nail Disease. Proceedings of a symposium. Vienna, Austria, 18 May 1993. (7910478)
1994
38
Epidemiology of fungal skin and nail disease: roundtable discussion held at Dermatology 2000, Vienna, 17 May 1993. (8186144)
1994
39
Candida onychomycosis--an evaluation of the candida species as primary keratinolytic yeasts in nail disease. (1381758)
1992
40
The spectrum of nail disease in patients with human immunodeficiency virus infection. (1619083)
1992
41
Single dose treatment of fungal nail disease. (1349100)
1992
42
Nail disease. (2018711)
1991
43
A systematic approach to examining the patient with nail disease. (2650839)
1989
44
Nail disease and dermatology. (2681287)
1989
45
Hand, foot and nail disease--a common manifestation of chronic dermatophytosis. (3231234)
1988
46
Candida onychomycosis--an evaluation of the role of Candida species in nail disease. (3342176)
1988
47
Toe nail disease secondary to poorly fitting shoes or abnormal biomechanics. (4064760)
1985
48
THE ROLE OF PSEUDOMONAS AERUGINOSA IN NAIL DISEASE. (14043007)
1963
49
"Base coat" nail disease. Report of a case. (14788850)
1950

Variations for Nail Disease

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Nail Disease:

1
id Gene Name Type Significance SNP ID Assembly Location
1FZD6NM_001164615.1(FZD6): c.1750G> T (p.Glu584Ter)single nucleotide variantPathogenicrs151339002GRCh37Chr 8, 104342091: 104342091
2FZD6NM_001164615.1(FZD6): c.1531C> T (p.Arg511Cys)single nucleotide variantPathogenicrs151339003GRCh37Chr 8, 104340634: 104340634

Expression for genes affiliated with Nail Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nail Disease

Search GEO for disease gene expression data for Nail Disease.

Pathways for genes affiliated with Nail Disease

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Nail Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PLCD1, TUBB6
2
Show member pathways
8.7CEP76, ESCO1, SEH1L

Compounds for genes affiliated with Nail Disease

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GO Terms for genes affiliated with Nail Disease

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16Gene Ontology
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Biological processes related to Nail Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycleGO:0002788.7CEP76, ESCO1, SEH1L

Products for genes affiliated with Nail Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nail Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet