MCID: NLD001
MIFTS: 34

Nail Disease malady

Skin diseases category

Summaries for Nail Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your toenails and fingernails protect the tissues of your toes and fingers. they are made up of layers of a hardened protein called keratin, which is also in your hair and skin. the health of your nails can be a clue to your overall health. healthy nails are usually smooth and consistent in color. specific types of nail discoloration and changes in growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. white spots and vertical ridges are harmless. nail problems that sometimes require treatment include bacterial and fungal infections ingrown nails tumors warts keeping your nails clean, dry, and trimmed can help you avoid some problems. do not remove the cuticle, which can cause infection.

MalaCards: Nail Disease, also known as nail diseases, is related to psoriatic arthritis and arthritis. An important gene associated with Nail Disease is PLCD1 (phospholipase C, delta 1), and among its related pathways is Cell Cycle. Affiliated tissues include nail, skin and kidney.

Disease Ontology:8 An integumentary system disease that is located in nail.

Wikipedia:63 Nail diseases are distinct from diseases of the skin. Although nails are a skin appendage, they have... more...

Aliases & Classifications for Nail Disease

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Nail Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 10, Nail Disorder, Nonsyndromic Congenital, 9

Diseases related to Nail Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis10.3
2arthritis10.3
3psoriasis10.3
4skin disease10.1
5anonychia congenita10.0RSPO4
6paronychia9.9
7pemphigus9.9
8bone development disease9.9
9dermatophytosis9.9
10enthesopathy9.9
11hair disease9.9
12hodgkin's lymphoma9.9

Graphical network of diseases related to Nail Disease:



Diseases related to nail disease

Clinical Features for Nail Disease

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Drugs & Therapeutics for Nail Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nail Disease

Drug clinical trials:

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Search NIH Clinical Center for Nail Disease

Search CenterWatch for Nail Disease

Genetic Tests for Nail Disease

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Anatomical Context for Nail Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Nail Disease:

32
Skin, Kidney, Lung, Heart, Liver, Bone, Small intestine

FMA organs/tissues related to Nail Disease:

14
Nail

Animal Models for Nail Disease or affiliated genes

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Publications for Nail Disease

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Sources:
50PubMed
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Articles related to Nail Disease:

(show top 50)    (show all 86)
idTitleAuthorsYear
1
Nail Psoriasis, the unknown burden of disease. (24422908)
2014
2
Half-and-half nail in BehAset's disease. (23452026)
2014
3
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. (23988587)
2013
4
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. (23423871)
2013
5
Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis: results from PHOENIX 1. (24117389)
2013
6
Quiz page December 2013: Hypoplastic nails, bowed elbows, and nephrotic syndrome. Nail-patella syndrome (hereditary osteo-onychodysplasia, Turner-Keiser syndrome, Fong disease). (24267390)
2013
7
Drug-related nail disease. (24079591)
2013
8
Ultrasonographic assessment of nail in psoriatic disease shows a link between onychopathy and distal interphalangeal joint extensor tendon enthesopathy. (23128597)
2012
9
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. (22383354)
2012
10
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. (22156725)
2012
11
Assessment of psoriatic nail disease activity by rheumatologists: comment on the article by Lubrano et al. (22623218)
2012
12
Optical coherence tomography: a new tool to assess nail disease in psoriasis? (21791896)
2011
13
Association between nail-fold capillary findings and disease activity in dermatomyositis. (21258053)
2011
14
Nail-patella syndrome (Fong disease). (20143059)
2010
15
Nail disease in pemphigus vulgaris. (19903430)
2009
16
Clinical practice. Fungal nail disease. (19439745)
2009
17
Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. (19686380)
2009
18
The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? (19424069)
2009
19
Management of psoriatic nail disease. (19341941)
2009
20
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year. (18083272)
2008
21
Gene symbol: LMX1B. Disease: Nail-Patella syndrome. (18386349)
2008
22
Alefacept in the treatment of psoriatic nail disease: a proof of concept study. (16673801)
2006
23
Phenotype severity and genetic variation at the disease locus: an investigation of nail dysplasia in the nail patella syndrome. (15638822)
2005
24
Alefacept in the treatment of psoriatic nail disease: a small case series. (15928640)
2005
25
Extended report: nail disease in psoriatic arthritis--clinically important, potentially treatable and often overlooked. (15113998)
2004
26
One interpretation of a psychometric study of patients with nail disease. (12664041)
2003
27
Yellow nail syndrome or diffuse lymphatic network disease. (12587788)
2002
28
Nails in the coffin: increasing evidence for the role of rheumatic disease in the cardiovascular mortality of rheumatoid arthritis. (11762929)
2001
29
Recurrence of fungal nail disease and the dissociation of relapse from re-infection. (11501665)
2001
30
Nail matrix arrest in the course of hand, foot and mouth disease. (11760019)
2001
31
Yellow nail syndrome and bilateral cystic lung disease. (9888218)
1998
32
Itraconazole now indicated to treat fungal nail disease. (11361668)
1996
33
Pediatric nail disease. (7742236)
1995
34
The differential diagnosis of nail disease. (11361432)
1995
35
Oral therapeutic agents in fungal nail disease. (8077514)
1994
36
Lamisil -- A New Measure in Antifungal Therapy in Skin and Nail Disease. Proceedings of a symposium. Vienna, Austria, 18 May 1993. (7910478)
1994
37
Epidemiology of fungal skin and nail disease: roundtable discussion held at Dermatology 2000, Vienna, 17 May 1993. (8186144)
1994
38
Single dose treatment of fungal nail disease. (1349100)
1992
39
Nail disease. (2018711)
1991
40
A systematic approach to examining the patient with nail disease. (2650839)
1989
41
Nail disease and dermatology. (2681287)
1989
42
Vasculitis and renal disease in nail-patella syndrome: case report and literature review. (3662646)
1987
43
Nail dystrophy in dyskeratosis congenita and chronic graft-vs-host disease. (3707164)
1986
44
Urea plaster for softening diseased nails in the treatment of tinea unguium. (2962190)
1986
45
Toe nail disease secondary to poorly fitting shoes or abnormal biomechanics. (4064760)
1985
46
Letterer-Siwe disease with nail involvement. (6851645)
1983
47
The yellow nail syndrome, bronchiectasis and Raynaud's disease--a relationship. (1012130)
1976
48
Hereditary onycho-osteodysplasia (the nail-patella syndrome) with nephrosis-like renal disease in a newborn boy. (5423458)
1970
49
Determination of acidic glycosaminoglycans (mucopolysaccharides) in urine by an ion exchange method. Application to "collagenoses", gargoylism, the nail-patella syndrome and Farber's disease. (4226725)
1967
50
NAIL-PATELLA SYNDROME (ONYCHO-OSTEODYSPLASIA) WITH ASSOCIATED BOWEN'S DISEASE AND PAGET'S DISEASE OF BONE. (14068148)
1963

Genetic Variations for Nail Disease

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Expression for genes affiliated with Nail Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nail Disease

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Pathways for genes affiliated with Nail Disease

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Sources:
53Reactome
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Pathways related to Nail Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.3CEP76, ESCO1, SEH1L, TUBB6

Compounds for genes affiliated with Nail Disease

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GO Terms for genes affiliated with Nail Disease

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16Gene Ontology
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Biological processes related to Nail Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycleGO:0002788.7CEP76, ESCO1, SEH1L

Products for genes affiliated with Nail Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nail Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet