MCID: NLD009
MIFTS: 27

Nail Disorder, Nonsyndromic Congenital, 1 malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Aliases & Descriptions for Nail Disorder, Nonsyndromic Congenital, 1:

Name: Nail Disorder, Nonsyndromic Congenital, 1 50
Twenty-Nail Dystrophy 11 46 52
Nonsyndromic Congenital Nail Disorder 1 11 13
Autosomal Dominant Nail Dysplasia 46 52
 
Onychodystrophy Totalis 46 52
Onychodystrophy Totalis, Isolated 46
Twenty Nail Dystrophy 66

Characteristics:

Orphanet epidemiological data:

52
twenty-nail dystrophy:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy

HPO:

62
nail disorder, nonsyndromic congenital, 1:
Inheritance: autosomal dominant inheritance
Onset and clinical course: slow progression


Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

OMIM50 161050
Disease Ontology11 DOID:0080079
Orphanet52 ORPHA79153
ICD10 via Orphanet29 L60.3

Summaries for Nail Disorder, Nonsyndromic Congenital, 1

About this section
OMIM:50 Many types of nonsyndromic congenital nail disorders (NDNC) have been described. Twenty-nail dystrophy (TND), also... (161050) more...

MalaCards based summary: Nail Disorder, Nonsyndromic Congenital, 1, also known as twenty-nail dystrophy, is related to lichen planus and alopecia, and has symptoms including thick nail, thin nail and nail dysplasia. An important gene associated with Nail Disorder, Nonsyndromic Congenital, 1 is FZD6 (Frizzled Class Receptor 6), and among its related pathways is Primary immunodeficiency. Affiliated tissues include skin, and related mouse phenotypes are no phenotypic analysis and normal.

NIH Rare Diseases:46 Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes.  the surface of all twenty nails develop ridges, splitting, and roughening (similar to sandpaper).  the nails may also be dull and brittle. this condition most commonly occurs in childhood, but it can occur at any age.  the exact cause is unknown; but in some cases, it appears to be associated with other skin conditions such as lichen planus, eczema, psoriasis and alopecia areata. many cases of twenty-nail dystrophy that begin gradually in early childhood tend to disappear naturally as the child ages. last updated: 7/4/2012

Related Diseases for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Graphical network of the top 20 diseases related to Nail Disorder, Nonsyndromic Congenital, 1:



Diseases related to nail disorder, nonsyndromic congenital, 1

Symptoms for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Symptoms by clinical synopsis from OMIM:

161050

Clinical features from OMIM:

161050

HPO human phenotypes related to Nail Disorder, Nonsyndromic Congenital, 1:

id Description Frequency HPO Source Accession
1 thick nail rare (5%) HP:0001805
2 thin nail HP:0001816
3 nail dysplasia HP:0002164

UMLS symptoms related to Nail Disorder, Nonsyndromic Congenital, 1:


thin nails

Drugs & Therapeutics for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Nail Disorder, Nonsyndromic Congenital, 1

Genetic Tests for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Anatomical Context for Nail Disorder, Nonsyndromic Congenital, 1

About this section

MalaCards organs/tissues related to Nail Disorder, Nonsyndromic Congenital, 1:

34
Skin

Animal Models for Nail Disorder, Nonsyndromic Congenital, 1 or affiliated genes

About this section

MGI Mouse Phenotypes related to Nail Disorder, Nonsyndromic Congenital, 1:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1AIRE, CD79A, PROS1, TP63
2MP:00028737.6AIRE, CD79A, FZD6, PROS1, TBX22, TP63

Publications for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Variations for Nail Disorder, Nonsyndromic Congenital, 1

About this section

Expression for genes affiliated with Nail Disorder, Nonsyndromic Congenital, 1

About this section
Search GEO for disease gene expression data for Nail Disorder, Nonsyndromic Congenital, 1.

Pathways for genes affiliated with Nail Disorder, Nonsyndromic Congenital, 1

About this section

Pathways related to Nail Disorder, Nonsyndromic Congenital, 1 according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3AIRE, CD79A

GO Terms for genes affiliated with Nail Disorder, Nonsyndromic Congenital, 1

About this section

Biological processes related to Nail Disorder, Nonsyndromic Congenital, 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hair follicle developmentGO:00019429.6FZD6, TP63
2establishment of planar polarityGO:00017369.5FZD6, TP63

Sources for Nail Disorder, Nonsyndromic Congenital, 1

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet