Nail Disorder, Nonsyndromic Congenital, 1 malady
Categories: Genetic diseases, Rare diseases, Skin diseases
Aliases & Descriptions for Nail Disorder, Nonsyndromic Congenital, 1:
Orphanet epidemiological data:52
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases
Rare skin diseases
OMIM:50 Many types of nonsyndromic congenital nail disorders (NDNC) have been described. Twenty-nail dystrophy (TND), also... (161050) more...
MalaCards based summary: Nail Disorder, Nonsyndromic Congenital, 1, also known as twenty-nail dystrophy, is related to lichen planus and alopecia, and has symptoms including thick nail, thin nail and nail dysplasia. An important gene associated with Nail Disorder, Nonsyndromic Congenital, 1 is FZD6 (Frizzled Class Receptor 6), and among its related pathways is Primary immunodeficiency. Affiliated tissues include skin, and related mouse phenotypes are no phenotypic analysis and normal.
NIH Rare Diseases:46 Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes. the surface of all twenty nails develop ridges, splitting, and roughening (similar to sandpaper). the nails may also be dull and brittle. this condition most commonly occurs in childhood, but it can occur at any age. the exact cause is unknown; but in some cases, it appears to be associated with other skin conditions such as lichen planus, eczema, psoriasis and alopecia areata. many cases of twenty-nail dystrophy that begin gradually in early childhood tend to disappear naturally as the child ages. last updated: 7/4/2012
UMLS symptoms related to Nail Disorder, Nonsyndromic Congenital, 1:thin nails
MalaCards organs/tissues related to Nail Disorder, Nonsyndromic Congenital, 1:34
Search GEO for disease gene expression data for Nail Disorder, Nonsyndromic Congenital, 1.
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet