Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases
Aliases & Descriptions for Narcolepsy:
Orphanet epidemiological data:52
Prevalence: 1-5/10000 (Europe),1-5/10000 (Norway),1-5/10000 (Finland),1-5/10000 (China); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy
narcolepsy without cataplexy:
Prevalence: 1-5/10000 (United States); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases
ICD10: 29 28
Rare neurological diseases
NIH Rare Diseases:46 Narcolepsy is a chronic brain disorder that involves poor control of sleep-wake cycles. people with narcolepsy have episodes of extreme daytime sleepiness and sudden, irresistible bouts of sleep (called "sleep attacks") that can occur at any time, and may last from seconds or minutes. other signs and symptoms may include cataplexy (a sudden loss of muscle tone that makes a person go limp or unable to move); vivid dream-like images or hallucinations; and/or total paralysis just before falling asleep or after waking-up. narcolepsy may have several causes, the most common being low levels of the neurotransmitter hypocretin (for various possible reasons). the disorder is usually sporadic but some cases are familial. there is no cure, but some symptoms can be managed with medicines and lifestyle changes. last updated: 4/27/2015
MalaCards based summary: Narcolepsy, also known as narcolepsy-cataplexy syndrome, is related to narcolepsy 1 and cerebellar ataxia, deafness, and narcolepsy, autosomal dominant, and has symptoms including hallucinations, muscle weakness and memory impairment. An important gene associated with Narcolepsy is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways are Staphylococcus aureus infection and CTLA4 Signaling. The drugs methylphenidate and methylphenidate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotype nervous system.
Disease Ontology:11 A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.
Genetics Home Reference:24 Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.
NINDS:47 Narcolepsy is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. At various times throughout the day, people with narcolepsy experience irresistable bouts of
Wikipedia:69 Narcolepsy is a long term neurological disorder that involves a decreased ability to regulate sleep-wake... more...
Symptoms:52 (show all 14)
HPO human phenotypes related to Narcolepsy:(show all 9)
UMLS symptoms related to Narcolepsy:hemiplegia, sleep disturbances, hallucinations, hypnagogic, excessive daytime somnolence, sleeplessness, sluggishness
Drugs for Narcolepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 38)
Interventional clinical trials:(show top 50) (show all 91)
Search NIH Clinical Center for Narcolepsy
Inferred drug relations via UMLS66/NDF-RT44:
Genetic tests related to Narcolepsy:
MalaCards organs/tissues related to Narcolepsy:34
Brain, Eye, Testes, Heart, T cells, Amygdala, Skin
Articles related to Narcolepsy:(show top 50) (show all 777)
Search GEO for disease gene expression data for Narcolepsy.
Pathways related to Narcolepsy according to GeneCards Suite gene sharing:
Cellular components related to Narcolepsy according to GeneCards Suite gene sharing:
Biological processes related to Narcolepsy according to GeneCards Suite gene sharing:(show all 8)
Molecular functions related to Narcolepsy according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet