MCID: NRC002
MIFTS: 75

Narcolepsy malady

Neuronal diseases category

Summaries for Narcolepsy

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. the disorder is estimated to affect about one in every 2,000 americans. most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. however, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress. last updated: 3/9/2011

MalaCards: Narcolepsy, also known as narcolepsy-cataplexy syndrome, is related to sleep disorder and obesity, and has symptoms including somnolence/hypersomnia/parasomnia, delirium/hallucination and psychic/behavioural troubles. An important gene associated with Narcolepsy is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Alcoholism. The drugs methylphenidate and methylphenidate hydrochloride and the compounds acetylcholine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.

Genetics Home Reference:21 Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.

NINDS:43 Narcolepsy is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. At various times throughout the day, people with narcolepsy experience irresistable bouts of

Wikipedia:63 Narcolepsy /ˈnɑrkəˌlɛpsi/, also known as hypnolepsy, is a chronic neurological disorder caused by... more...

Aliases & Classifications for Narcolepsy

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 43NINDS, 44Novoseek, 60UMLS, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
narcolepsy without cataplexy:
Age of onset: Adolescence / Young adulthood; Age of death: Normal


Aliases & Descriptions:

narcolepsy 8 42 22 21 43 44 60
narcolepsy-cataplexy syndrome 42 60
narcoleptic syndrome 42 21
gelineau syndrome 42 21
paroxysmal sleep 8 42
narcolepsy, without cataplexy 8
narcolepsy without cataplexy 48
gelineau's syndrome 42


External Ids:

Disease Ontology8 DOID:8986
NCIt39 C84489
MeSH34 D009290
ICD9CM27 347.0
ICD10 via Orphanet26 G47.4

Related Diseases for Narcolepsy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Narcolepsy family:

Narcolepsy 2 Narcolepsy 7
Narcolepsy 5 Narcolepsy 1
Narcolepsy 6 Narcolepsy 3
Narcolepsy 4

Diseases related to Narcolepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1sleep disorder31.0HCRT, HCRTR1, HCRTR2, CLOCK
2obesity30.5TNFRSF1B, DRD2, ATXN3, HCRT, HCRTR2, CLOCK
3schizophrenia30.4MOG, TNFRSF1B, DRD1, DRD2, HLA-DQB1, HLA-DRB1
4multiple sclerosis30.4HLA-DRB1, HLA-DQB1
5restless legs syndrome30.3HCRT, DRD2
6parkinson's disease30.3DRD2
7bipolar disorder30.0DRD1, DRD2, CLOCK
8neuromyelitis optica30.0MOG
9mood disorder29.8CLOCK, HCRT, DRD2, DRD1
10encephalomyelitis29.8MOG, TNFRSF1B, HLA-DQB1
11acute disseminated encephalomyelitis29.8MOG
12obsessive-compulsive disorder29.8DRD2, DRD1
13influenza10.5
14neuronitis10.4
15narcolepsy 110.4
16rem sleep behavior disorder10.4
17cerebellar ataxia, deafness, and narcolepsy, autosomal dominant10.2
18anxiety disorder10.2
19cerebritis10.1
20cerebellar ataxia10.1
21narcolepsy 610.1
22narcolepsy 310.1
23narcolepsy 410.1
24periodic limb movement disorder10.0
25eating disorder10.0
26encephalitis10.0
27neurologic diseases10.0
28narcolepsy risk factor10.0
29narcolepsy 210.0
30narcolepsy 710.0
31narcolepsy 510.0
32migraine10.0HCRT, DRD2, DRD1
33guillain-barre syndrome10.0HCRT, TNFRSF1B, MOG
34huntington's disease10.0HCRT, ATXN3, DRD2, DRD1
35hypersensitivity reaction type ii disease10.0HLA-DRB1, HLA-DQB1, TNFRSF1B, MOG
36drug addiction10.0DRD1, DRD2, HCRT
37juvenile rheumatoid arthritis10.0TNFRSF1B, HLA-DQB1, HLA-DRB1
38attention deficit hyperactivity disorder10.0DRD2, DRD1
39dementia10.0HCRT, TNFRSF1B
40adrenal adenoma10.0HCRT, HCRTR1, HCRTR2
41anorexia nervosa10.0HCRT
42multiple system atrophy10.0ATXN3, DRD2
43optic neuritis10.0MOG
44myotonic dystrophy10.0HCRT
45cryoglobulinemic vasculitis10.0IGHM
46neuropathy10.0NPTX2
47systemic lupus erythematosus10.0TNFRSF1B, HLA-DQB1, HLA-DRB1, IGHM
48cocaine dependence10.0DRD2
49delayed sleep phase syndrome10.0CLOCK
50striatonigral degeneration10.0DRD2

Graphical network of the top 20 diseases related to Narcolepsy:



Diseases related to narcolepsy

Clinical Features for Narcolepsy

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48
  • somnolence/hypersomnia/parasomnia
  • delirium/hallucination
  • psychic/behavioural troubles
  • sleep and vigilance disorders

Drugs & Therapeutics for Narcolepsy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Narcolepsy

About this section
Sources:
22GTR
See all sources

Genetic tests related to Narcolepsy:

id Genetic test Affiliating Genes
1 Narcolepsy22

Anatomical Context for Narcolepsy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Narcolepsy:

32
Brain, Eye, Testes, T cells, Amygdala, Heart, Cortex, Skin, Colon, Hypothalamus, Prefrontal cortex

Animal Models for Narcolepsy or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Narcolepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.5ATXN3, MOG, TNFRSF1B, NPTX2, DRD1, DRD2
2MP:000363111.4ATXN3, MOG, TNFRSF1B, NPTX2, DRD1, DRD2
3MP:000538111.0TNFRSF1B, CLOCK, DRD1, DRD2, HLA-DQB1, IGHM
4MP:000536911.0DRD1, DRD2, HLA-DQB1, HCRT, HCRTR2, TNFRSF1B
5MP:000538810.7TNFRSF1B, DRD2, HLA-DQB1, IGHM, DRD1, HCRT

Publications for Narcolepsy

About this section
Sources:
50PubMed
See all sources

Articles related to Narcolepsy:

(show top 50)    (show all 655)
idTitleAuthorsYear
1
Neuroimaging findings in narcolepsy with cataplexy. (23526549)
2013
2
Association between H1N1 vaccination and narcolepsy-cataplexy: flu to sleep. (23486883)
2013
3
The Pandemrix - narcolepsy tragedy: how it started and what we know today. (23016673)
2013
4
Elevated glial fibrillary acidic protein levels in the cerebrospinal fluid of patients with narcolepsy. (23746601)
2013
5
Genetic association, seasonal infections and autoimmune basis of narcolepsy. (23497937)
2013
6
A remarkable effect of alemtuzumab in a patient suffering from narcolepsy with cataplexy. (22142323)
2012
7
AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. (22470453)
2012
8
Obstetric management of a patient with narcolepsy and cataplexy: a case report. (22928134)
2012
9
Cyclic alternating pattern in narcolepsy patients and healthy controls after partial and total sleep deprivation. (21458370)
2011
10
Recent advances in the treatment of narcolepsy. (21748548)
2011
11
PandemrixA^, (H1N1)v influenza and reported cases of narcolepsy. (21232649)
2011
12
Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience. (21389728)
2011
13
Narcolepsy: a review. (21931493)
2011
14
Autonomic disturbances in narcolepsy. (20634114)
2011
15
Diagnosing narcolepsy with cataplexy on history alone: challenging the International Classification of Sleep Disorders (ICSD-2) criteria. (21658163)
2011
16
WHO backs further probes into possible link between H1N1 vaccine and narcolepsy in children. (21307106)
2011
17
Explorations of clinical trials and pharmacovigilance databases of MF59Ar-adjuvanted influenza vaccines for associated cases of narcolepsy: a six-month update. (21851329)
2011
18
Olfactory dysfunction in narcolepsy with and without cataplexy. (20513636)
2010
19
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. (21102987)
2010
20
Narcolepsy in Parkinson's disease. (20518604)
2010
21
Restless legs syndrome associated with narcolepsy and somnambulism. (19703790)
2010
22
A brain PET study in patients with narcolepsy-cataplexy. (19850578)
2010
23
A novel approach to treating morning sleep inertia in narcolepsy. (20191943)
2010
24
Rhythmic movements and sleep paralysis in narcolepsy with cataplexy: a video-polygraphic study. (20199889)
2010
25
Childhood narcolepsy with partial facial cataplexy: a diagnostic dilemma. (19147400)
2009
26
Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. (19520267)
2009
27
Narcolepsy an often missed diagnosis: first documented case from India. (19770566)
2009
28
Bispectral index monitoring of a narcolepsy-cataplexy episode during regional anesthesia. (19151297)
2009
29
Neuroimaging of narcolepsy. (19689307)
2009
30
Active and passive smoking and risk of narcolepsy in people with HLA DQB1*0602: a population-based case-control study. (19039244)
2009
31
Nocturnal aspects of narcolepsy with cataplexy. (18282773)
2008
32
Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy. (18769859)
2008
33
Clinical, behavioural and polysomnographic correlates of cataplexy in patients with narcolepsy/cataplexy. (17681883)
2008
34
An autoantibody in narcolepsy disrupts colonic migrating motor complexes. (19052222)
2008
35
Immunoadsorption for the treatment of narcolepsy with cataplexy. (19066723)
2008
36
Familial narcolepsy. (17530575)
2007
37
Screening the human prepro-orexin gene in a single-centre narcolepsy cohort. (17576097)
2007
38
Evaluation of hypothalamic-specific autoimmunity in patients with narcolepsy. (17310861)
2007
39
Psychosocial adjustment following relief of chronic narcolepsy. (17368100)
2007
40
A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness. (17162989)
2006
41
CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency? (16944669)
2006
42
A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms. (15091316)
2004
43
Decreased cerebrospinal fluid hypocretin-1 levels near the onset of narcolepsy in 2 prepubertal children. (12938807)
2003
44
Month of birth as a risk factor for narcolepsy. (14572117)
2003
45
Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. (14655912)
2003
46
A brief history of hypocretin/orexin and narcolepsy. (11682268)
2001
47
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. (11756606)
2001
48
The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. (11104852)
2000
49
Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-raclopride. (7969966)
1994
50
Disorders of excessive sleepiness: narcolepsy and hypersomnia. (3332460)
1987

Genetic Variations for Narcolepsy

About this section

Expression for genes affiliated with Narcolepsy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Narcolepsy

Search GEO for disease gene expression data for Narcolepsy.

Pathways for genes affiliated with Narcolepsy

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Narcolepsy

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Narcolepsy according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1acetylcholine44 49 28 11 2415.4HCRTR2, HCRTR1, HCRT, DRD2, DRD1, MOG
2glutamate4411.3NPTX2, DRD1, DRD2, HLA-DQB1, HLA-DRB1, HCRT
3norepinephrine44 11 2413.3TNFRSF1B, DRD1, DRD2, HCRT, HCRTR2
4dopamine44 28 11 2414.3DRD1, DRD2, HCRT, HCRTR1, CLOCK
5acth4411.2HCRTR2, HCRTR1, HCRT, TNFRSF1B
6methylphenidate44 49 1113.2DRD1, DRD2, HCRT
7adenylate4411.2TNFRSF1B, DRD1, DRD2, HCRT, HCRTR1
8amphetamine44 1112.1DRD1, DRD2, HCRT
9act-0785732811.1HCRTR1, HCRTR2
101-(2-bromo-phenyl)-3-((4s,5s)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea2811.1HCRTR2, HCRTR1
11[3h]sb-6740422811.1HCRTR2, HCRTR1
12sb-3348672811.1HCRTR2, HCRTR1
13sb-4081242811.1HCRTR2, HCRTR1
14skf 383934411.1DRD2, DRD1
15Acetophenazine1111.1DRD2, DRD1
161-(2,4-dibromo-phenyl)-3-((4s,5s)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea2811.1HCRTR1, HCRTR2
17orexin-b2811.1HCRTR2, HCRTR1
18orexin-a2811.1HCRTR2, HCRTR1
19c-peptide4411.1TNFRSF1B, HLA-DRB1, HCRT
20[ala11, d-leu15]orexin-b2811.1HCRTR2, HCRTR1
21mk-60962811.1HCRTR2, HCRTR1
22suvorexant2811.1HCRTR2, HCRTR1
23sb-6498682811.1HCRTR2, HCRTR1
24Thiethylperazine1111.0DRD1, DRD2
25Carphenazine1111.0DRD1, DRD2
26eedq4411.0DRD2, DRD1
27cis flupentixol2811.0DRD2, DRD1
28eticlopride28 4412.0DRD2, DRD1
29opiate4411.0DRD1, DRD2, HCRT
30Triflupromazine1111.0DRD1, DRD2
31(+)-butaclamol28 4412.0DRD1, DRD2
32sch 233904411.0DRD1, DRD2
33zuclopenthixol44 49 1113.0DRD1, DRD2
34Thioproperazine1111.0DRD1, DRD2
35Acepromazine1111.0DRD1, DRD2
36loxapine28 44 1113.0DRD1, DRD2
37thiothixene28 1111.9DRD1, DRD2
38d amphetamine4410.9DRD2, DRD1
39Pipotiazine1110.9DRD1, DRD2
40minaprine44 1111.9DRD1, DRD2
41clozapine44 28 49 1113.9TNFRSF1B, DRD1, DRD2
42flupenthixol44 49 1112.9DRD1, DRD2
43raclopride44 2811.8DRD2, DRD1
44rotigotine44 28 1112.8DRD2, DRD1
45amoxapine44 28 1112.8DRD2, DRD1
46catecholamine4410.7HCRTR2, HCRT, DRD1
47Chlorprothixene1110.7DRD2, DRD1
48Propiomazine1110.6DRD1, DRD2
49fluphenazine28 44 1112.5DRD1, DRD2
50haloperidol44 28 2 49 1114.4HCRT, DRD2, DRD1

GO Terms for genes affiliated with Narcolepsy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Narcolepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.6HLA-DRB1, HLA-DQB1

Biological processes related to Narcolepsy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.2NPTX2, ATXN3, HCRT, HCRTR1, HCRTR2
2feeding behaviorGO:00763111.1HCRTR2, HCRTR1, DRD2
3regulation of dopamine uptake involved in synaptic transmissionGO:05158411.0DRD2, DRD1
4cerebral cortex GABAergic interneuron migrationGO:02185310.9DRD1, DRD2
5immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.9HLA-DQB1, HLA-DRB1
6humoral immune response mediated by circulating immunoglobulinGO:00245510.9HLA-DRB1, HLA-DQB1
7peristalsisGO:03043210.9DRD2, DRD1
8phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.9DRD2, DRD1
9neuropeptide signaling pathwayGO:00721810.9HCRT, HCRTR1, HCRTR2
10dopamine metabolic processGO:04241710.9DRD1, DRD2
11synaptic transmission, dopaminergicGO:00196310.8DRD2, DRD1
12behavioral response to cocaineGO:04814810.8DRD2, DRD1
13immune responseGO:00695510.8IGHM, HLA-DRB1, HLA-DQB1, TNFRSF1B
14prepulse inhibitionGO:06013410.8DRD2, DRD1
15elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.7DRD1, DRD2
16circadian regulation of gene expressionGO:03292210.6DRD2, CLOCK
17grooming behaviorGO:00762510.5DRD1, DRD2
18temperature homeostasisGO:00165910.3DRD2, DRD1

Molecular functions related to Narcolepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.6HLA-DRB1, HLA-DQB1
2orexin receptor activityGO:01649910.5HCRTR2, HCRTR1
3dopamine bindingGO:03524010.3DRD2, DRD1

Products for genes affiliated with Narcolepsy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Narcolepsy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet