MCID: NRC002
MIFTS: 75

Narcolepsy malady

Neuronal diseases category

Summaries for Narcolepsy

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. the disorder is estimated to affect about one in every 2,000 americans. most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. however, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress. last updated: 3/9/2011

MalaCards: Narcolepsy, also known as narcolepsy-cataplexy syndrome, is related to sleep disorder and obesity, and has symptoms including psychic/behavioural troubles, delirium/hallucination and somnolence/hypersomnia/parasomnia. An important gene associated with Narcolepsy is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Alcoholism. The drugs amphetamine and dextroamphetamine sulfate and the compounds acetylcholine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.

NINDS:43 Narcolepsy is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. At various times throughout the day, people with narcolepsy experience irresistable bouts of

Genetics Home Reference:21 Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.

Wikipedia:63 Narcolepsy /ˈnɑrkəˌlɛpsi/, also known as hypnolepsy, is a chronic neurological disorder caused by... more...

Aliases & Classifications for Narcolepsy

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 43NINDS, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
narcolepsy without cataplexy:
Age of onset: Adolescence / Young adulthood; Age of death: Normal


Aliases & Descriptions:

narcolepsy 8 42 22 21 43 44 60
narcolepsy-cataplexy syndrome 42 60
narcoleptic syndrome 42 21
gelineau syndrome 42 21
paroxysmal sleep 8 42
narcolepsy, without cataplexy 8
narcolepsy without cataplexy 48
gelineau's syndrome 42


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Disease Ontology8 DOID:8986
NCIt39 C84489
MeSH34 D009290
ICD9CM27 347.0
ICD10 via Orphanet26 G47.4

Related Diseases for Narcolepsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Narcolepsy family:

Narcolepsy 2 Narcolepsy 7
Narcolepsy 5 Narcolepsy 1
Narcolepsy 6 Narcolepsy 3
Narcolepsy 4

Diseases related to Narcolepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1sleep disorder31.0HCRT, HCRTR1, HCRTR2, CLOCK
2obesity30.5TNFRSF1B, DRD2, ATXN3, HCRT, HCRTR2, CLOCK
3schizophrenia30.4MOG, TNFRSF1B, DRD1, DRD2, HLA-DQB1, HLA-DRB1
4multiple sclerosis30.4HLA-DRB1, HLA-DQB1
5restless legs syndrome30.3HCRT, DRD2
6parkinson's disease30.3DRD2
7bipolar disorder30.0DRD1, DRD2, CLOCK
8neuromyelitis optica30.0MOG
9mood disorder29.8CLOCK, HCRT, DRD2, DRD1
10encephalomyelitis29.8MOG, TNFRSF1B, HLA-DQB1
11acute disseminated encephalomyelitis29.8MOG
12obsessive-compulsive disorder29.8DRD2, DRD1
13influenza10.5
14neuronitis10.4
15narcolepsy 110.4
16rem sleep behavior disorder10.4
17cerebellar ataxia, deafness, and narcolepsy, autosomal dominant10.2
18anxiety disorder10.2
19cerebritis10.1
20cerebellar ataxia10.1
21narcolepsy 610.1
22narcolepsy 310.1
23narcolepsy 410.1
24periodic limb movement disorder10.0
25eating disorder10.0
26encephalitis10.0
27neurologic diseases10.0
28narcolepsy risk factor10.0
29narcolepsy 210.0
30narcolepsy 710.0
31narcolepsy 510.0
32migraine10.0HCRT, DRD2, DRD1
33guillain-barre syndrome10.0HCRT, TNFRSF1B, MOG
34huntington's disease10.0HCRT, ATXN3, DRD2, DRD1
35hypersensitivity reaction type ii disease10.0HLA-DRB1, HLA-DQB1, TNFRSF1B, MOG
36drug addiction10.0DRD1, DRD2, HCRT
37juvenile rheumatoid arthritis10.0TNFRSF1B, HLA-DQB1, HLA-DRB1
38attention deficit hyperactivity disorder10.0DRD2, DRD1
39dementia10.0HCRT, TNFRSF1B
40adrenal adenoma10.0HCRT, HCRTR1, HCRTR2
41anorexia nervosa10.0HCRT
42multiple system atrophy10.0ATXN3, DRD2
43optic neuritis10.0MOG
44myotonic dystrophy10.0HCRT
45cryoglobulinemic vasculitis10.0IGHM
46neuropathy10.0NPTX2
47systemic lupus erythematosus10.0TNFRSF1B, HLA-DQB1, HLA-DRB1, IGHM
48cocaine dependence10.0DRD2
49delayed sleep phase syndrome10.0CLOCK
50striatonigral degeneration10.0DRD2

Graphical network of the top 20 diseases related to Narcolepsy:



Diseases related to narcolepsy

Clinical Features for Narcolepsy

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Sources:
48Orphanet
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Symptoms:

48
  • psychic/behavioural troubles
  • delirium/hallucination
  • somnolence/hypersomnia/parasomnia
  • sleep and vigilance disorders

Drugs & Therapeutics for Narcolepsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Narcolepsy

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Sources:
22GTR
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Genetic tests related to Narcolepsy:

id Genetic test Affiliating Genes
1 Narcolepsy22

Anatomical Context for Narcolepsy

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32MalaCards
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MalaCards organs/tissues related to Narcolepsy:

32
Brain, Testes, Eye, T cells, Amygdala, Heart, Cortex, Skin, Colon, Prefrontal cortex, Hypothalamus

Animal Models for Narcolepsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Narcolepsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.5CLOCK, MOG, TNFRSF1B, NPTX2, DRD1, DRD2
2MP:000363111.4DRD1, NPTX2, TNFRSF1B, MOG, DRD2, HLA-DQB1
3MP:000538111.0CLOCK, IGHM, HLA-DQB1, DRD2, DRD1, TNFRSF1B
4MP:000536911.0MOG, TNFRSF1B, DRD1, DRD2, HLA-DQB1, HCRT
5MP:000538810.7TNFRSF1B, DRD1, DRD2, HLA-DQB1, IGHM, HCRT

Publications for Narcolepsy

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Sources:
50PubMed
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Articles related to Narcolepsy:

(show top 50)    (show all 655)
idTitleAuthorsYear
1
DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe. (24381371)
2014
2
The impact of gender on timeliness of narcolepsy diagnosis. (24426826)
2014
3
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient. (23904686)
2013
4
Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy. (23734110)
2013
5
Commentary on the article by Ingravallo et al. "The burden of narcolepsy with cataplexy: how disease history and clinical features influence socio-economic outcomes" Sleep medicine 2012; 13:1293-1300. (23403286)
2013
6
Effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy. (23997366)
2013
7
The autoimmune basis of narcolepsy. (23725858)
2013
8
A patient with narcolepsy with cataplexy and multiple sclerosis: two different diseases that may share pathophysiologic mechanisms? (23688944)
2013
9
Narcolepsy and sleep-disordered breathing. (22182320)
2012
10
DTI reveals hypothalamic and brainstem white matter lesions in patients with idiopathic narcolepsy. (22541810)
2012
11
Pathogenesis of narcolepsy: from HLA association to hypocretin deficiency]. (22696207)
2012
12
High pain frequency in narcolepsy with cataplexy. (21570344)
2011
13
Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. (21930661)
2011
14
Periodic limb movements during sleep in children with narcolepsy. (22171197)
2011
15
Narcolepsy and cataplexy. (21056228)
2011
16
Sleep: Narcolepsy--a role for TRIB2 autoantibodies? (20455283)
2010
17
Antistreptococcal Antibodies Found in Patients with Narcolepsy. (20424974)
2010
18
Pseudocataplexy in narcolepsy with cataplexy. (20471315)
2010
19
Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy. (20614847)
2010
20
Obstructive sleep apnea in narcolepsy. (19699146)
2010
21
Olfactory dysfunction in narcolepsy with cataplexy. (20817549)
2010
22
Neuraxial anaesthesia for caesarean section in a patient with narcolepsy and cataplexy. (20833530)
2010
23
Use of venlafaxine in the treatment of a canine narcolepsy-cataplexy case. (20137001)
2010
24
Administration of desflurane with bistrectal index monitoring in a patient with narcolepsy undergoing anesthesia. (20187488)
2009
25
Treatment of narcolepsy. (19496692)
2009
26
Using magnetic resonance spectroscopy in narcolepsy to study the limbic mechanisms of cataplexy. (19480221)
2009
27
Narcolepsy. Interview by Norman Sussman. (19678414)
2009
28
Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment. (19841387)
2009
29
Narcolepsy: clinical decision making for the primary care physician. (20016433)
2009
30
Management of narcolepsy. (18570605)
2008
31
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. (18820697)
2008
32
Real-time automated neural-network sleep classifier using single channel EEG recording for detection of narcolepsy episodes. (19162864)
2008
33
Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. (18714784)
2008
34
Anaesthetic management and perioperative monitoring of a patient with narcolepsy. (17977105)
2007
35
Modafinil-induced hippocampal activation in narcolepsy. (17600622)
2007
36
Introduction: narcolepsy and excessive daytime sleepiness: from the bench to the bedside. (18078358)
2007
37
Therapeutic advances in narcolepsy. (17475553)
2007
38
Narcolepsy, head injury, and the problem of causality. (17561630)
2005
39
The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy. (15320603)
2004
40
Diagnosis of childhood narcolepsy and significance of HLA in its diagnosis]. (15157381)
2004
41
Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil. (11990384)
2002
42
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. (11179016)
2001
43
ApoE polymorphisms in narcolepsy. (11560764)
2001
44
Hypocretin (orexin) deficiency in human narcolepsy. (10615891)
2000
45
Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans. (11164570)
2000
46
Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy. (11132147)
2000
47
Narcolepsy: a key role for hypocretins (orexins) (10481905)
1999
48
The narcolepsy-associated DRw15,DQw6,Dw2 haplotype has no unique HLA-DQA or -DQB restriction fragments and does not extend to the HLA-DP subregion. (1973684)
1990
49
Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. (2906157)
1988
50
REM sleep and NREM sleep in narcolepsy and hypersomnia. (4183371)
1969

Genetic Variations for Narcolepsy

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Expression for genes affiliated with Narcolepsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Narcolepsy

Search GEO for disease gene expression data for Narcolepsy.

Pathways for genes affiliated with Narcolepsy

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Narcolepsy

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Narcolepsy according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1acetylcholine44 49 28 11 2415.4MOG, HCRTR2, HCRTR1, HCRT, DRD2, DRD1
2glutamate4411.3HLA-DQB1, DRD2, DRD1, HCRT, NPTX2, HLA-DRB1
3norepinephrine44 11 2413.3HCRTR2, HCRT, DRD2, TNFRSF1B, DRD1
4dopamine44 28 11 2414.3CLOCK, HCRTR1, DRD1, DRD2, HCRT
5acth4411.2TNFRSF1B, HCRT, HCRTR2, HCRTR1
6methylphenidate44 49 1113.2DRD1, DRD2, HCRT
7adenylate4411.2DRD1, HCRTR1, HCRT, DRD2, TNFRSF1B
8amphetamine44 1112.1HCRT, DRD2, DRD1
9mk-60962811.1HCRTR2, HCRTR1
10suvorexant2811.1HCRTR1, HCRTR2
11[ala11, d-leu15]orexin-b2811.1HCRTR1, HCRTR2
12Acetophenazine1111.1DRD1, DRD2
13orexin-a2811.1HCRTR1, HCRTR2
14skf 383934411.1DRD1, DRD2
15orexin-b2811.1HCRTR1, HCRTR2
16sb-6498682811.1HCRTR2, HCRTR1
171-(2-bromo-phenyl)-3-((4s,5s)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea2811.1HCRTR1, HCRTR2
18[3h]sb-6740422811.1HCRTR1, HCRTR2
19c-peptide4411.1HCRT, HLA-DRB1, TNFRSF1B
20act-0785732811.1HCRTR1, HCRTR2
21sb-3348672811.1HCRTR2, HCRTR1
221-(2,4-dibromo-phenyl)-3-((4s,5s)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea2811.1HCRTR2, HCRTR1
23sb-4081242811.1HCRTR2, HCRTR1
24Carphenazine1111.0DRD2, DRD1
25Thiethylperazine1111.0DRD2, DRD1
26eticlopride28 4412.0DRD1, DRD2
27cis flupentixol2811.0DRD1, DRD2
28eedq4411.0DRD1, DRD2
29opiate4411.0DRD2, DRD1, HCRT
30Triflupromazine1111.0DRD1, DRD2
31zuclopenthixol44 49 1113.0DRD1, DRD2
32sch 233904411.0DRD1, DRD2
33(+)-butaclamol28 4412.0DRD1, DRD2
34thiothixene28 1112.0DRD2, DRD1
35loxapine28 44 1113.0DRD2, DRD1
36Acepromazine1111.0DRD1, DRD2
37Thioproperazine1110.9DRD1, DRD2
38d amphetamine4410.9DRD1, DRD2
39flupenthixol44 49 1112.9DRD1, DRD2
40Pipotiazine1110.9DRD1, DRD2
41clozapine44 28 49 1113.9DRD1, TNFRSF1B, DRD2
42minaprine44 1111.9DRD2, DRD1
43rotigotine44 28 1112.8DRD2, DRD1
44raclopride44 2811.8DRD1, DRD2
45amoxapine44 28 1112.8DRD2, DRD1
46catecholamine4410.7HCRT, HCRTR2, DRD1
47Chlorprothixene1110.7DRD1, DRD2
48fluphenazine28 44 1112.6DRD1, DRD2
49Propiomazine1110.5DRD2, DRD1
50haloperidol44 28 2 49 1114.4HCRT, DRD2, DRD1

GO Terms for genes affiliated with Narcolepsy

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16Gene Ontology
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Cellular components related to Narcolepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.6HLA-DRB1, HLA-DQB1

Biological processes related to Narcolepsy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.2NPTX2, ATXN3, HCRT, HCRTR1, HCRTR2
2feeding behaviorGO:00763111.1HCRTR2, HCRTR1, DRD2
3regulation of dopamine uptake involved in synaptic transmissionGO:05158411.0DRD2, DRD1
4cerebral cortex GABAergic interneuron migrationGO:02185310.9DRD1, DRD2
5immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.9HLA-DQB1, HLA-DRB1
6humoral immune response mediated by circulating immunoglobulinGO:00245510.9HLA-DRB1, HLA-DQB1
7peristalsisGO:03043210.9DRD2, DRD1
8phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.9DRD2, DRD1
9neuropeptide signaling pathwayGO:00721810.9HCRT, HCRTR1, HCRTR2
10dopamine metabolic processGO:04241710.9DRD1, DRD2
11synaptic transmission, dopaminergicGO:00196310.8DRD2, DRD1
12behavioral response to cocaineGO:04814810.8DRD2, DRD1
13immune responseGO:00695510.8IGHM, HLA-DRB1, HLA-DQB1, TNFRSF1B
14prepulse inhibitionGO:06013410.8DRD2, DRD1
15elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.7DRD1, DRD2
16circadian regulation of gene expressionGO:03292210.6DRD2, CLOCK
17grooming behaviorGO:00762510.5DRD1, DRD2
18temperature homeostasisGO:00165910.3DRD2, DRD1

Molecular functions related to Narcolepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.6HLA-DRB1, HLA-DQB1
2orexin receptor activityGO:01649910.5HCRTR2, HCRTR1
3dopamine bindingGO:03524010.3DRD2, DRD1

Products for genes affiliated with Narcolepsy

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Narcolepsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet