Narcolepsy malady

NIH Rare Diseases: Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. Three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. The disorder is estimated to affect about one in every 2,000 Americans. Most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. However, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. Other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress.³⁰

MalaCards: Narcolepsy, also known as narcoleptic syndrome, is related to narcolepsy 2 and hypersomnia. An important gene associated with Narcolepsy is NRCLP4 (Narcolepsy 4), and among its related pathways are Cell adhesion molecules (CAMs) and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs methylphenidate hydrochloride and amphetamine adipate and the compounds c-peptide and nicotine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Disease Ontology: A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.⁶

NINDS: Narcolepsy is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. At various times throughout the day, people with narcolepsy experience irresistable bouts of³¹

Genetics Home Reference: Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.¹⁷

Wikipedia: Narcolepsy is a chronic neurological disorder caused by the brain\'s inability to regulate sleep-wake...⁴⁴ more...

Aliases & Descriptions:

narcolepsy 6 7 30 17 31 8 32 43 narcoleptic syndrome 30 17 gelineau syndrome 30 17 paroxysmal sleep 6 30

narcolepsy-cataplexy syndrome 30 narcolepsy, without cataplexy 6 gelineau's syndrome 30

Disease types for narcolepsy family:

narcolepsy 2	narcolepsy 3
narcolepsy 4	narcolepsy 5
narcolepsy 1

Diseases related to narcolepsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 430)

id	Related Disease	Score	Top Affiliating Genes
1	narcolepsy 2	31.2	NRCLP, HCRT
2	hypersomnia	30.9	CHKB, INS, HLA-DQB1, HLA-DRB1, TRA@, HCRT
3	sleep apnea	29.8	LEP, LSL, HCRT
4	kleine-levin syndrome	28.5	HLA-DRB1, HCRT
5	anxiety disorder	28.4	MAOA, HTR2A, HTR3A, TPH1, DRD2, COMT
6	sleep disorder	28.2	CLOCK, LEP, MOG, INS, APOE, HLA-DQB1
7	neuromyelitis optica	27.7	MOG, AQP4, HLA-DQA1, HLA-DQB1, HLA-DRB1, HCRT
8	alcoholism	27.1	IL1RN, MAOA, HTR1B, HTR2A, HTR3A, TPH1
9	multiple sclerosis	27.0	MOG, IL1RN, APOE, HLA-DQA1, HLA-DQB1, HLA-DRB1
10	neurodegenerative disease	26.7	ATXN3, APOE, MAOA, HTR2A, TNFRSF1B, DRD2
11	parkinson's disease	26.0	CIITA, CHKB, APOE, MAOA, HTR1B, HTR2A
12	schizophrenia	25.9	IL1RN, MAOA, HTR2A, TNF, DRD2, NOTCH4
13	apnea	25.2	LEP, INS, APOE, HTR1B, HTR2A, HTR3A
14	bipolar disorder	24.0	CLOCK, LEP, IL1RN, MAOA, HTR1B, HTR2A
15	mood disorder	23.6	CLOCK, LEP, IL1RN, MAOA, HTR1B, HTR2A
16	twinning	23.2	LEP, ATXN3, INS, APOE, MAOA, HLA-DQA1
17	obesity	21.4	CLOCK, SCG5, LEP, CIITA, CHKB, ATXN3
18	neuronitis	20.3	CLOCK, SCG5, LEP, CIITA, CHKB, BAG1
19	cerebritis	19.6	LEP, CHKB, INS, IL1RN, AQP4, APOE
20	dysthymic disorder	13.6	MAOA, HTR2A, HCRT
21	tubulointerstitial nephritis and uveitis	13.6	HLA-DQA1, HLA-DQB1, HLA-DRB1
22	bulimia nervosa	13.6	LEP, HTR3A, COMT, LSL
23	sepiapterin reductase deficiency	13.5	ATXN3, TPH1, DRD2
24	novelty seeking personality	13.5	MAOA, DRD2, COMT
25	common wart	13.5	HLA-DQA1, HLA-DQB1, HLA-DRB1
26	pityriasis rosea	13.5	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4
27	celiac disease	13.5	HLA-DQA1, HLA-DQB1
28	drug addiction	13.5	DRD1, DRD2, PDYN, HCRT, GABBR1
29	seasonal affective disorder	13.5	CLOCK, HTR2A, TPH1, GABBR1
30	insomnia	13.5	CLOCK, LEP, HTR2A, HTR3A, HCRT, HCRTR1
31	dental caries	13.4	HLA-DQB1, HLA-DRB1, STATH, PRAP1
32	dyskinesia of esophagus	13.4	HTR1B, HTR2A, DRD2, COMT, PDYN
33	premature ejaculation	13.4	LEP, HTR1B, HTR3A, LSL
34	eating disorder	13.4	LEP, HTR2A, HTR3A, COMT, LSL, HCRT
35	pathological gambling	13.4	MAOA, DRD1, DRD2
36	growth mental deficiency syndrome of myhre	13.4	CLOCK, LEP, MAOA, DRD2, COMT, LSL
37	antisocial personality disorder	13.4	MAOA, HTR1B, HTR2A, DRD2
38	major affective disorder	13.3	HTR2A, HTR3A, TPH1
39	neuroleptic malignant syndrome	13.3	CHKB, HTR2A, HTR3A, DRD2
40	congenital generalized lipodystrophy	13.3	LEP, INS, LSL
41	recurrent respiratory papillomatosis	13.3	HLA-DQA1, HLA-DQB1, HLA-DRB1
42	leprosy	13.3	HLA-DQA1, HLA-DQB1, HLA-DRB1, LTA
43	attention deficit hyperactivity disorder	13.3	MAOA, HTR1B, HTR2A, DRD1, DRD2, COMT
44	cocaine dependence	13.3	CLOCK, DRD1, DRD2, COMT, PDYN, GABBR1
45	phobia	13.2	MAOA, HTR3A, DRD2, COMT
46	21-hydroxylase deficiency	13.2	LEP, INS, HLA-DRB1, LSL
47	social phobia	13.2	MAOA, HTR3A, DRD2
48	neurotic disorder	13.2	MAOA, HTR2A, HTR3A, DRD2, COMT
49	personality disorder	13.2	MAOA, HTR1B, TPH1, DRD2
50	tremor	13.2	HTR2A, HTR3A, TPH1, DRD2, COMT

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amphetamine, amphetamine adipate, amphetamine aspartate, amphetamine sulfate, amphetamine/dextroamphetamine resin complex, dextroamphetamine, dextroamphetamine adipate, dextroamphetamine saccharate, dextroamphetamine sulfate, methylphenidate, methylphenidate hydrochloride, modafinil, pemoline

MalaCards organs/tissues related to narcolepsy:

²²

MGI Mouse Phenotypes related to narcolepsy:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.8	PPT2, TRIB2, HLA-DQB1, HLA-DQA1, IGHM, MX2
2	endocrine/exocrine gland phenotype	MP:0005379	9.6	LTA, PPT2, HTR2A, HTR1B, SCG5
3	liver/biliary system phenotype	MP:0005370	9.3	CLOCK, SCG5, BAG1, INS, DRD2, PPT2
4	respiratory system phenotype	MP:0005388	8.8	HCRT, DRD2, TPH1, IGHM, APOE, AQP4
5	skeleton phenotype	MP:0005390	8.7	PDYN, DRD2, TNFRSF1B, TNFRSF1A, HTR1B, INS
6	digestive/alimentary phenotype	MP:0005381	8.0	DRD1, DRD2, SST, PPT2, PDYN, HTR2A
7	immune system phenotype	MP:0005387	7.8	TNFRSF1A, DRD1, DRD2, PPT2, COMT, PRAP1
8	muscle phenotype	MP:0005369	7.3	TNFRSF1A, TNFRSF1B, DRD1, DRD2, PPT2, HCRT
9	adipose tissue phenotype	MP:0005375	7.3	GABBR1, PDYN, DRD2, TNFRSF1B, TNFRSF1A, TNF
10	nervous system phenotype	MP:0003631	6.7	DRD2, PPT2, NOTCH4, COMT, PDYN, LTA
11	integument phenotype	MP:0010771	6.2	TNF, TNFRSF1A, TNFRSF1B, DRD1, DRD2, PDYN
12	growth/size phenotype	MP:0005378	5.9	DRD1, DRD2, SST, NOTCH4, PDYN, LTA
13	cardiovascular system phenotype	MP:0005385	5.6	TNF, TNFRSF1A, TNFRSF1B, DRD1, DRD2, NOTCH4
14	behavior/neurological phenotype	MP:0005386	4.0	CHRNA5, TNFRSF1A, TNFRSF1B, DRD1, DRD2, SST
15	homeostasis/metabolism phenotype	MP:0005376	3.9	SST, DRD2, DRD1, TNFRSF1B, TNFRSF1A, NOTCH4

Articles related to narcolepsy:

(show top 50)    (show all 168)

id	Title	Authors	Year	Affiliating Genes
1	Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status. (20110394)	Han F.... Strohl K.P.	2010	HLA-DQB1
2	Does narcolepsy symptom severity vary according to HL A-DQB1*0602 allele status? (20120618)	Watson N.F.... Longstreth W.T.	2010	HLA-DQB1
3	An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (20677014)	Shimada M.... Tokunaga K.	2010	CHRNA5
4	Rapid eye movement sleep behaviour disorder in patien ts with narcolepsy is associated with hypocretin-1 deficiency. (20129934)	Knudsen S.... Jennum P.J.	2010	HCRT
5	Reduced amygdala activity during aversive conditionin g in human narcolepsy. (20373351)	Ponz A.... Bassetti C.L.	2010	HCRT
6	Hypocretin deficiency in narcolepsy with cataplexy is associated with a normal body core temperature modulation. (20854137)	Grimaldi D.... Cortelli P.	2010	HCRT
7	Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss? (20403960)	Fontana A.... Bassetti C.L.	2010	TNFRSF1B, CIITA, HCRT
8	Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit i n SALo Paulo. (19506770)	Coelho F.M.... Tufik S.	2009	HLA-DQB1, HCRT
9	Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implication s. (20008665)	Kanbayashi T.... Nishino S.	2009	AQP4, HCRT
10	Cell transplantation: a future therapy for narcolepsy ? (19689312)	Arias-CarriA^n O.... Murillo-rodrA-guez E.	2009	HCRT
11	Decreased CSF histamine in narcolepsy with and withou t low CSF hypocretin-1 in comparison to healthy controls. (19238804)	Nishino S.... Mignot E.	2009	HCRT
12	Narcolepsy as an initial manifestation of neuromyelit is optica with anti-aquaporin-4 antibody. (19266146)	Baba T.... Itoyama Y.	2009	AQP4
13	Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal Orexin A (Hypocretin-1). (18718966)	Baier P.C.... Hinze-Selch D.	2008	HCRT
14	Prevalence of narcolepsy in King County, Washington, USA. (19013100)	Longstreth W.T.... Velde S.	2008	HLA-DQB1
15	Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. (18714784)	Mishima K.... Nishino S.	2008	HCRTR2, HCRTR1
16	Narcolepsy with cataplexy (18805301)	Dauvilliers Y.... Arnulf I.	2008	HCRT
17	Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. (17256150)	Rubio J.P.... Foote S.J.	2007	HLA-DQB1, HLA-DRB1
18	Narcolepsy: pathophysiology and pharmacology. (18078360)	Nishino S.	2007	HCRT
19	Isolated mediotegmental lesion causing narcolepsy and rapid eye movement sleep behaviour disorder: a case evidencing a common pathway in narcolepsy and rapid eye movement sleep behaviour disorder. (17369596)	Mathis J.... Bassetti C.	2007	HCRT
20	Narcolepsy and the hypocretins. (16979425)	Wurtman R.J.	2006	HCRT
21	Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy. (16774153)	Tanaka S.... Honda M.	2006	HCRT
22	The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. (16766052)	Zeitzer J.M.... Mignot E.	2006	HCRT
23	Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. (16006155)	Nishino S.... Kanbayashi T.	2005	HCRT
24	Analysis of hypocretin (orexin) antibodies in patients with narcolepsy. (16171287)	Black J.L.... Slocumb N.L.	2005	SCG5, HCRT
25	Emerging therapies in narcolepsy-cataplexy. (16477963)	Mignot E.... Nishino S.	2005	HCRT
26	Diagnosis of childhood narcolepsy and significance of HLA in its diagnosis (15157381)	Wu H.S.... Chen C.H.	2004	HLA-DQB1, HLA-DRB1
27	Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA. (15309313)	Wieczorek S.... Epplen J.T.	2004	COMT, DRD2, GABBR1
28	The clinical spectrum of narcolepsy with cataplexy: a reappraisal. (15560774)	Sturzenegger C.... Bassetti C.L.	2004	HCRT
29	Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway. (15081654)	Khatami R.... Bassetti C.L.	2004	HCRT
30	HLA-DRB and -DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy (12887819)	Han F.... Ding D.J.	2003	HLA-DQB1, HLA-DRB1
31	Hypocretins/orexins and narcolepsy: from molecules to disease (14646798)	Peyron C.... Charnay Y.	2003	HCRT
32	TNFA promoter polymorphisms and narcolepsy. (12823767)	Wieczorek S.... Dahmen N.	2003	TNF, HLA-DRB1
33	CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. (14638887)	Dauvilliers Y.... Bassetti C.L.	2003	HCRT
34	Neurodegenerative, autoimmune and genetic processes of human and animal narcolepsy (14646805)	Dauvilliers Y.	2003	HCRT
35	Screening for anti-ganglioside antibodies in hypocretin-deficient human narcolepsy. (12676332)	Overeem S.... Lammers G.J.	2003	HCRT
36	Pharmacogenomics in the treatment of narcolepsy. (12517283)	Tafti M.... Dauvilliers Y.	2003	COMT
37	The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (12374492)	Mignot E.... Nishino S.	2002	HCRT
38	Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil. (11990384)	Dauvilliers Y.... Tafti M.	2002	COMT
39	Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy. (11723284)	Hungs M.... Mignot E.	2001	HCRT
40	CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. (11756606)	Ripley B.... Nishino S.	2001	HCRT
41	Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke. (11425947)	Scammell T.E.... Saper C.B.	2001	HCRT
42	Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. (11179016)	Mignot E.... Risch N.	2001	HLA-DQA1, HLA-DQB1, HLA-DRB1
43	A prepro-orexin gene polymorphism is associated with narcolepsy. (11148249)	Gencik M.... Epplen J.T.	2001	HCRT
44	The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. (11104852)	Fehr C.... Dahmen N.	2000	HTR1B
45	Reduced number of hypocretin neurons in human narcolepsy. (11055430)	Thannickal T.C.... Siegel J.M.	2000	HCRT
46	Narcolepsy: a key role for hypocretins (orexins) (10481905)	Siegel J.M.	1999	HCRT
47	Genetic studies in narcolepsy, a disorder affecting R EM sleep. (9987919)	Faraco J.... Mignot E.	1999	IGHV@
48	Dopamine D2 receptors quantified in vivo in human narcolepsy. (9024953)	MacFarlane J.G.... Nahmias C.	1997	DRD2
49	Positron emission tomography study of human narcolepsy: no increase in striatal dopamine D2 receptors. (7675236)	Rinne J.O.... Laihinen A.	1995	DRD2
50	Ritanserin, a 5-HT2 receptor blocker, as add-on treatment in narcolepsy. (1678203)	Lammers G.J.... Troost J.	1991	HTR2A

Genes related to narcolepsy according to GeneCards:

(show top 50)    (show all 65)

id	Symbol	Description	Score	GeneCards Section Context
1	NRCLP4	Narcolepsy 4	11.0	Aliases & Descriptions
2	NRCLP	Narcolepsy, HLA-associated	11.0	Aliases & Descriptions, Publications
3	NRCLP5	Narcolepsy 5	11.0	Aliases & Descriptions
4	NRCLP3	Narcolepsy 3	11.0	Publications, Aliases & Descriptions
5	NRCLP6	Narcolepsy 6	11.0	Aliases & Descriptions
6	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications, Functions
7	NPTX2	neuronal pentraxin II	11.0	Publications
8	HCRTR2	hypocretin (orexin) receptor 2	11.0	Publications
9	HCRTR1	hypocretin (orexin) receptor 1	11.0	Publications
10	IGHM	immunoglobulin heavy constant mu	11.0	Publications
11	ATXN3	ataxin 3	11.0	Publications
12	DRD1	dopamine receptor D1	11.0	Publications
13	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
14	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
15	CLOCK	clock homolog (mouse)	11.0	Publications
16	DRD2	dopamine receptor D2	11.0	Publications
17	COMT	catechol-O-methyltransferase	11.0	Publications
18	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
19	LSL	Leptin, serum levels of	11.0	Publications
20	LEP	leptin	11.0	Publications
21	LINC00165	long intergenic non-protein coding RNA 165	10.9	Publications
22	TRAJ10	T cell receptor alpha joining 10	10.9	Publications
23	LINC00162	long intergenic non-protein coding RNA 162	10.9	UniProt Related, Publications
24	LINC00163	long intergenic non-protein coding RNA 163	10.9	Publications
25	ENSG00000206305		10.9	Publications
26	ENSG00000232062		10.9	Publications
27	ENSG00000233209		10.9	Publications, UniProt Related
28	IGHV@	immunoglobulin heavy variable cluster	10.9	Publications
29	HLA-S	major histocompatibility complex, class I, S (pseudogene)	10.9	Publications
30	ATF6B	activating transcription factor 6 beta	10.9	Publications
31	PRAP1	proline-rich acidic protein 1	10.9	Publications
32	PPT2	palmitoyl-protein thioesterase 2	10.9	Publications
33	TRIB2	tribbles homolog 2 (Drosophila)	10.9	Publications
34	STATH	statherin	10.9	Publications
35	IFN1@	interferon, type 1, cluster	10.9	Publications
36	MOG	myelin oligodendrocyte glycoprotein	10.9	Publications
37	CPT1B	carnitine palmitoyltransferase 1B (muscle)	10.9	Publications
38	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	10.9	UniProt Related, Publications
39	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	10.9	Publications
40	AIF1	allograft inflammatory factor 1	10.9	Publications
41	AQP4	aquaporin 4	10.9	Publications
42	MX2	myxovirus (influenza virus) resistance 2 (mouse)	10.9	Publications
43	BAG1	BCL2-associated athanogene	10.9	Publications
44	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	10.9	Publications
45	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	10.9	Publications
46	CHRNA5	cholinergic receptor, nicotinic, alpha 5 (neuronal)	10.9	Publications
47	PDYN	prodynorphin	10.9	Publications
48	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	10.9	Publications
49	SCG5	secretogranin V (7B2 protein)	10.9	Publications
50	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	10.9	Publications

Pathways related to narcolepsy according to GeneDecks:

(show top 50)    (show all 53)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.5	HLA-DQA2
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.2	TPH1, HTR2A, MAOA
3	Amine ligand-binding receptors38	10.2	DRD2, DRD1, HTR2A, HTR1B
4	Graft-versus-host disease20	10.2	HLA-DRB4, HLA-DRB3, HLA-DQA2, HLA-DQA1
5	Immune response_ICOS pathway in T-helper cell41	10.1	TRA@, HLA-DRB4, HLA-DQA2
6	CTLA4 Signaling36	10.1	HLA-DRB4, HLA-DRB3, HLA-DQA2, HLA-DQA1
7	Immune response_NFAT in immune response41	10.0	TRA@, HLA-DRB4, HLA-DRB3, HLA-DQA2
8	CTL Mediated Apoptosis36	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
9	Calcium Mediated T-Cell Apoptosis36	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
10	Intestinal immune network for IgA production20	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
11	Autoimmune thyroid disease20	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
12	Staphylococcus aureus infection20	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
13	IL-4 Pathway36	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
14	Viral myocarditis20	9.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
15	ICos-ICosL Pathway in T-Helper Cell36	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
16	CD28 Signaling in T-Helper Cell36	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
17	Neuroactive ligand-receptor interaction20	9.8	CHRNA5, GABBR1, HCRTR2, HCRTR1, DRD2, DRD1
18	PKC-Theta Pathway36	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
19	ITK and TCR Signaling36	9.7	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
20	MHC class II antigen presentation38	9.7	ENSG00000233209, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
21	Immune response Antigen presentation by MHC class II10	9.7	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
22	G-protein signaling N-RAS regulation pathway10	9.6	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
23	Immune response IL-22 signaling pathway10	9.6	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, TRA@
24	TCR Signaling36	9.6	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
25	Immune response NFAT in immune response10	9.6	TRA@, HLA-DRB4, HLA-DRB3, HLA-DQB1, HLA-DQA1, IGHM
26	Immune response T cell receptor signaling pathway10	9.6	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
27	Immune response_Antigen presentation by MHC class II41	9.6	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
28	Immune response ICOS pathway in T-helper cell10	9.5	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
29	G-protein signaling_N-RAS regulation pathway41	9.5	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
30	Immune response_IL-22 signaling pathway41	9.5	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
31	Phagosome20	9.5	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
32	Immune response_T cell receptor signaling pathway41	9.5	TRA@, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
33	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	TNF, TNFRSF1A, TNFRSF1B
34	Adipocytokine signaling pathway20	9.5	CPT1B, TNFRSF1B, TNFRSF1A, TNF, LEP
35	CDC42 Pathway36	9.4	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
36	IL-9 Pathway36	9.4	LTA, TNFRSF1B, TNFRSF1A, TNF
37	Asthma20	9.3	TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
38	Allograft rejection20	9.3	TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
39	Leishmaniasis20	9.3	TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
40	Rheumatoid arthritis20	9.3	TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
41	Cellular Transformation by HTLV136	9.3	LTA, TNFRSF1B, TNFRSF1A, TNF
42	Systemic lupus erythematosus20	9.2	TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
43	Antigen processing and presentation20	9.1	TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
44	Transcription_NF-kB signaling pathway41	9.0	LTA, TNFRSF1B, TNFRSF1A, TNF, TRA@
45	THC Differentiation Pathway36	9.0	TNFRSF1B, TNFRSF1A, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1
46	Toxoplasmosis20	8.8	TNFRSF1A, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
47	Influenza A20	8.8	TNFRSF1A, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
48	Tuberculosis20	8.7	TNFRSF1A, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
49	Transcription NF-kB signaling pathway10	8.5	LTA, TNFRSF1A, TNF, TRA@
50	Type I diabetes mellitus20	8.5	LTA, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1

Compounds related to narcolepsy according to GeneDecks:

(show top 50)    (show all 180)

id	Compound	Score	Top Affiliating Genes
1	c-peptide32	10.6	LSL, HCRT, TNFRSF1B, LEP
2	nicotine32 34 9 9	13.5	CHRNA5, PDYN
3	ropinirole32 9 9	12.3	DRD2, COMT, DRD1, HTR2A, HTR1B
4	methylphenidate32 9 9	12.3	MAOA, DRD1, DRD2, HCRT, COMT
5	pergolide32 9 9	12.2	COMT, DRD2, HTR1B, HTR2A, DRD1
6	glucose32	10.2	HCRTR1, PDYN, GABBR1
7	spiperone32	10.2	DRD2, DRD1, HTR3A, HTR2A
8	pramipexole32 9 9	12.2	DRD1, COMT, HTR2A, DRD2, HTR1B
9	ketanserin32	10.0	HTR3A, HTR1B, HTR2A, DRD1, DRD2
10	bromocriptine32 9 9	12.0	HTR2A, SST
11	minaprine32 9 9	12.0	MAOA, HTR2A, DRD1, DRD2
12	quetiapine32 9 18 9	12.9	LEP, HTR1B, HTR3A, HTR2A, LSL, DRD2
13	maoa32	9.9	COMT, DRD2, HTR1B, TPH1, HTR2A, MAOA
14	cabergoline32 9 9	11.8	HTR1B, HTR2A, DRD1, DRD2, SST, COMT
15	ritanserin32	9.8	HTR2A, HTR3A, DRD2, HTR1B
16	fenfluramine32 9 9	11.8	LEP, TPH1, HTR3A, HTR1B, HTR2A
17	clozapine32 34 9 9	12.8	LEP, DRD2, DRD1, CHKB, TNFRSF1B, HTR3A
18	risperidone32 34 9 18 9	13.8	HTR3A, HTR2A, CHKB, LEP, DRD1, LSL
19	methamphetamine32 9 9	11.8	MAOA, PDYN, COMT, DRD2, DRD1, TPH1
20	citalopram32 34 9 18 9	13.6	HTR3A, LEP, MAOA, HTR2A, LSL, TPH1
21	cocaine32 9 9	11.6	LEP, COMT, PDYN, HCRT, DRD2, GABBR1
22	paroxetine32 34 9 9	12.5	LEP, COMT, TPH1, HTR3A, HTR2A, HTR1B
23	fluvoxamine32 34 9 9	12.5	CLOCK, MAOA, HTR3A, TPH1, HTR2A
24	fluoxetine32 34 9 9	12.5	TPH1, HTR2A, DRD2, HTR3A, HTR1B, MAOA
25	amphetamine32 9 9	11.3	GABBR1, MAOA, HCRT, TPH1, DRD1, SST
26	intralipid32	9.3	LEP, LSL, SST, APOE
27	catecholamine32	9.2	MAOA, TPH1, DRD1, COMT, PDYN, HCRTR2
28	nash32	9.2	TNFRSF1A, TNF, LEP, INS, LSL
29	etanercept32 9 9	11.0	LEP, TNF, TNFRSF1A, IL1RN, TNFRSF1B, LTA
30	levodopa32 9 9	10.9	COMT, MAOA, HTR1B, TPH1, DRD1, SST
31	cysteine32	8.8	SCG5, CHKB, AQP4, TPH1, TNFRSF1A, ATXN3
32	5-hydroxytryptamine32	8.8	HCRT, MAOA, HTR1B, HTR2A, HTR3A, COMT
33	gaba32 42	9.8	PDYN, GABBR1, LEP, MAOA, HTR3A, TPH1
34	methotrexate32 34 42 9 9	12.7	TNF, HLA-DRB1, IL1RN, CHKB, LEP, HLA-S
35	acth32	8.7	PDYN, HCRT, HCRTR2, HCRTR1, SST, IL1RN
36	infliximab32 9 9	10.5	IL1RN, TNF, TNFRSF1A, TNFRSF1B, LTA, LSL
37	neopterin32	8.5	TPH1, TNF, CHKB, TNFRSF1B, TNFRSF1A, LTA
38	nmda32 42	9.3	HCRT, COMT, DRD2, SCG5, DRD1, APOE
39	olanzapine32 34 9 18 9	12.2	INS, LEP, HTR1B, HTR2A, HTR3A, DRD2
40	epinephrine32 9 18 9	11.2	INS, PDYN, HCRT, COMT, SST, DRD2
41	glutamate32	8.1	SCG5, LEP, INS, AQP4, MAOA, DRD1
42	thyroxine32 18	8.8	HCRT, LTA, SST, APOE, INS, CHKB
43	acetylcholine32 9 18 9	10.7	HCRTR1, HCRTR2, HCRT, LEP, MOG, APOE
44	testosterone32 9 18 9	10.7	LSL, SST, TNFRSF1A, TNFRSF1B, HTR1B, APOE
45	dopamine32 9 18 9	10.6	CHKB, MAOA, HTR1B, HTR3A, TPH1, TNFRSF1A
46	histamine32 18	8.5	SCG5, IL1RN, AQP4, MAOA, HTR3A, TNF
47	norepinephrine32 9 18 9	9.9	GABBR1, LEP, HCRTR2, CHKB, INS, HTR3A
48	nitric oxide32 9 18 9	9.8	LTA, PDYN, DRD1, TNFRSF1B, LSL, HCRT
49	estrogen32	6.8	LTA, PDYN, LSL, LEP, HCRT, COMT
50	dexamethasone32 42 34 9 9	10.2	CIITA, SCG5, LEP, LSL, LTA, HCRT

Cellular components related to narcolepsy according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	9.8	HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4
2	clathrin-coated endocytic vesicle membrane	GO:030669	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.7	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
4	trans-Golgi network membrane	GO:032588	9.7	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
5	transport vesicle membrane	GO:030658	9.7	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
6	ER to Golgi transport vesicle membrane	GO:012507	9.7	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
7	endocytic vesicle membrane	GO:030666	9.6	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
8	lysosomal membrane	GO:005765	9.4	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
9	neuronal cell body	GO:043025	8.3	APOE, HTR3A, DRD1, SST, GABBR1, CHRNA5
10	integral to plasma membrane	GO:005887	7.4	TNFRSF1A, DRD1, DRD2, NOTCH4, HCRTR1, HCRTR2
11	extracellular region	GO:005576	6.6	PDYN, HCRT, STATH, PRAP1, NPTX2, GABBR1
12	plasma membrane	GO:005886	5.1	TNF, TNFRSF1A, TNFRSF1B, DRD1, DRD2, NOTCH4

Biological processes related to narcolepsy according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.4	DRD2, HTR2A, HTR1B
2	regulation of dopamine secretion	GO:014059	10.4	DRD2, HTR2A, HTR1B
3	regulation of interleukin-10 secretion	GO:2001179	10.4	HLA-DRB4, HLA-DRB3, HLA-DRB1
4	regulation of interleukin-4 production	GO:032673	10.4	HLA-DRB4, HLA-DRB3, HLA-DRB1
5	negative regulation of circadian sleep/wake cycle, sleep	GO:042321	10.3	DRD2, DRD1
6	temperature homeostasis	GO:001659	10.3	HTR2A, DRD1, DRD2
7	inflammatory response to antigenic stimulus	GO:002437	10.3	HLA-DRB4, HLA-DRB3, HLA-DRB1
8	eating behavior	GO:042755	10.3	LEP, DRD1, HCRT
9	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:035774	10.3	HLA-DRB4, HLA-DRB3, HLA-DRB1
10	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.3	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4
11	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.3	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
12	T-helper 1 type immune response	GO:042088	10.2	HLA-DRB4, HLA-DRB3, HLA-DRB1
13	detection of bacterium	GO:016045	10.2	HLA-DRB4, HLA-DRB3, HLA-DRB1
14	neuropeptide signaling pathway	GO:007218	10.1	SCG5, PDYN, HCRT, HCRTR1, HCRTR2
15	T cell costimulation	GO:031295	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
16	T cell receptor signaling pathway	GO:050852	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
17	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
18	interferon-gamma-mediated signaling pathway	GO:060333	9.6	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
19	response to cocaine	GO:042220	9.5	HTR1B, HTR3A, DRD2
20	positive regulation of chronic inflammatory response to antigenic stimulus	GO:002876	9.4	LTA, TNF
21	cytokine-mediated signaling pathway	GO:019221	9.1	TNFRSF1A, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
22	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.1	APOE, TNF, TNFRSF1B
23	immune response	GO:006955	9.0	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
24	synaptic transmission	GO:007268	8.4	ATXN3, CHRNA5, GABBR1, NPTX2, HCRTR2, HCRTR1
25	response to drug	GO:042493	8.2	LTA, COMT, SST, DRD2, DRD1, TNF

Molecular functions related to narcolepsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	orexin receptor activity	GO:016499	10.1	HCRTR2, HCRTR1
2	drug binding	GO:008144	10.0	HTR1B, HTR2A, DRD1, DRD2
3	peptide antigen binding	GO:042605	10.0	HLA-DRB1, HLA-DRB3, HLA-DRB4
4	serotonin receptor activity	GO:004993	9.8	HTR3A, HTR2A, HTR1B
5	MHC class II receptor activity	GO:032395	9.6	HLA-DQA1, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
6	serotonin binding	GO:051378	9.6	MAOA, HTR1B, HTR2A, HTR3A