MCID: NRC002
MIFTS: 67

Narcolepsy malady

Summaries for Narcolepsy

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. the disorder is estimated to affect about one in every 2,000 americans. most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. however, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress. last updated: 3/9/2011

MalaCards: Narcolepsy, also known as narcolepsy-cataplexy syndrome, is related to sleep disorder and restless legs syndrome. An important gene associated with Narcolepsy is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Orexin and neuropeptides FF and QRFP bind to their respective receptors. The drugs methylphenidate and methylphenidate hydrochloride and the compounds acetylcholine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.

Genetics Home Reference:21 Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.

NINDS:44 Narcolepsy is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. At various times throughout the day, people with narcolepsy experience irresistable bouts of

Wikipedia:64 Narcolepsy /ˈnɑrkəˌlɛpsi/, also known as hypnolepsy, is a chronic neurological disorder caused by... more...

Aliases & Classifications for Narcolepsy

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 44NINDS, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

narcolepsy 8 43 22 21 44 45 61
narcolepsy-cataplexy syndrome 43 61
narcoleptic syndrome 43 21
gelineau syndrome 43 21
paroxysmal sleep 8 43
narcolepsy, without cataplexy 8
gelineau's syndrome 43


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Disease Ontology8 DOID:8986
NCIt40 C84489
MeSH35 D009290
ICD9CM27 347.0

Related Diseases for Narcolepsy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Narcolepsy family:

narcolepsy 2 narcolepsy 7
narcolepsy 5 narcolepsy 1
narcolepsy 6 narcolepsy 3
narcolepsy 4

Diseases related to Narcolepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1sleep disorder31.1HCRT, HCRTR1, HCRTR2, CLOCK
2restless legs syndrome30.4DRD2, HCRT
3bipolar disorder30.1DRD1, DRD2, CLOCK
4neuromyelitis optica30.1MOG
5parkinson's disease29.8LSL, DRD1, DRD2, HCRT
6acute disseminated encephalomyelitis29.8MOG
7obsessive-compulsive disorder29.8DRD2, DRD1
8hypersomnia10.8
9narcolepsy 110.6
10n syndrome10.5
11sleep apnea10.5
12narcolepsy 210.4
13narcolepsy risk factor10.3
14cerebellar ataxia, deafness, and narcolepsy, autosomal dominant10.3
15anxiety disorder10.2
16narcolepsy 410.2
17idiopathic hypersomnolence10.1
18ataxia10.1
19narcolepsy 610.1
20narcolepsy 310.1
21periodic limb movement disorder10.1
22neurologic diseases10.1
23precocious puberty10.1
24narcolepsy 710.1
25narcolepsy 510.1
26obesity10.0CLOCK, HCRTR2, HCRT, ATXN3, DRD2, TNFRSF1B
27schizophrenia10.0MOG, TNFRSF1B, DRD1, DRD2, HLA-DRB1, HCRT
28multiple sclerosis10.0MOG, LSL, TNFRSF1B, DRD2, HLA-DRB1, HCRT
29hypersensitivity reaction type ii disease10.0MOG, TNFRSF1B, DRD2, HLA-DRB1, IGHM
30mood disorder10.0DRD1, DRD2, HCRT, CLOCK
31huntington's disease10.0HCRT, ATXN3, DRD2, DRD1
32migraine10.0DRD1, DRD2, HCRT
33guillain-barre syndrome10.0MOG, TNFRSF1B, HCRT
34drug addiction10.0HCRT, DRD2, DRD1
35eating disorder10.0HCRTR1, HCRT, LSL
36adrenal adenoma10.0HCRTR2, HCRTR1, HCRT
37anorexia nervosa10.0HCRT, LSL
38attention deficit hyperactivity disorder10.0DRD2, DRD1
39multiple system atrophy10.0DRD2, ATXN3
40dementia10.0TNFRSF1B, HCRT
41bulimia nervosa10.0LSL
42myotonic dystrophy10.0HCRT
43ischemia10.0DRD2, HCRT, HCRTR1
44pheochromocytoma10.0DRD2, HCRT, HCRTR1, HCRTR2
45encephalomyelitis10.0MOG, TNFRSF1B
46hepatitis c10.0LSL, TNFRSF1B, HLA-DRB1
47cocaine dependence10.0DRD2
48optic neuritis10.0MOG
49delayed sleep phase syndrome10.0CLOCK
50striatonigral degeneration10.0DRD2

Graphical network of the top 20 diseases related to Narcolepsy:



Diseases related to narcolepsy

Clinical Features for Narcolepsy

Drugs & Therapeutics for Narcolepsy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Narcolepsy

Sources:
22GTR
See all sources

Genetic tests related to Narcolepsy:

id Genetic test Affiliating Genes
1 Narcolepsy22

Anatomical Context for Narcolepsy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Narcolepsy:

33
Brain, Cortex, Heart, Colon, Skin, T cells, B cells, Prefrontal cortex, Hypothalamus, Amygdala

Animal Models for Narcolepsy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Narcolepsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.3TNFRSF1B, NPTX2, DRD1, DRD2, ATXN3, HCRT
2MP:000538611.0CLOCK, MOG, TNFRSF1B, NPTX2, DRD1, DRD2

Publications for Narcolepsy

Sources:
51PubMed
See all sources

Articles related to Narcolepsy:

(show top 50)    (show all 656)
idTitleAuthorsYear
1
Childhood narcolepsy with cataplexy: a newly reported phenotype of an old disease? (23831236)
2013
2
Childhood narcolepsy- a rare disorder. (22949083)
2013
3
Incomplete sleep paralysis as the first symptom of narcolepsy. (23746823)
2013
4
A patient with rhythmic movements during REM sleep. Narcolepsy with cataplexy associated with sleep-related rhythmic movements. (23772198)
2013
5
Positive effects of massage therapy on a patient with narcolepsy. (23730398)
2013
6
Sleep-disordered breathing and periodic limb movements in narcolepsy with cataplexy: a systematic analysis of 35 consecutive patients. (23689193)
2013
7
Development of Parkinson's disease in patients with Narcolepsy. (22231845)
2012
8
Zonisamide-Induced Psychosis in a Patient With Bipolar Disorder and Narcolepsy. (22713527)
2012
9
Tolerance and efficacy of sodium oxybate in childhood narcolepsy with cataplexy: a retrospective study. (22547897)
2012
10
Narcolepsy presenting as schizophrenia: a literature review and two case reports. (21637632)
2011
11
The pathophysiologic basis of secondary narcolepsy and hypersomnia. (21298561)
2011
12
Familial aggregation of narcolepsy. (22036600)
2011
13
Long-term follow-up of patients with narcolepsy-cataplexy treated with sodium oxybate (Xyrem). (21206362)
2011
14
Overnight distribution and motor characteristics of REM sleep behaviour disorder episodes in patients with narcolepsy-cataplexy. (21704555)
2011
15
Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. (20129934)
2010
16
Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. (20175400)
2010
17
Tianeptine treating narcolepsy. Case report. (20035252)
2009
18
REM sleep without atonia in narcolepsy. (20038925)
2009
19
REM sleep behaviour disorder in narcolepsy. (20054743)
2009
20
Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. (19725248)
2009
21
Hypocretin measurement in an Icelandic foal with narcolepsy. (19909431)
2009
22
Body mass index-independent metabolic alterations in narcolepsy with cataplexy. (19928388)
2009
23
An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. (18295497)
2008
24
Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy. (18363310)
2008
25
A neural network method for detection of obstructive sleep apnea and narcolepsy based on pupil size and EEG. (18269961)
2008
26
Narcolepsy: immunological aspects. (18291691)
2008
27
The epidemiology of narcolepsy. (17310860)
2007
28
A case-control study of the environmental risk factors for narcolepsy. (18043003)
2007
29
Periodic leg movements during sleep and wakefulness in narcolepsy. (17716283)
2007
30
Treatment of narcolepsy with cataplexy. (17398302)
2007
31
Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. (18246980)
2007
32
Narcolepsy and the hypocretins. (16979425)
2006
33
Molecular genetics and treatment of narcolepsy. (16754256)
2006
34
Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA. (15309313)
2004
35
Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset. (15562415)
2004
36
Screening for anti-ganglioside antibodies in hypocretin-deficient human narcolepsy. (12676332)
2003
37
HLA-DRB and -DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy]. (12887819)
2003
38
Pharmacogenomics in the treatment of narcolepsy. (12517283)
2003
39
Neurodegenerative, autoimmune and genetic processes of human and animal narcolepsy]. (14646805)
2003
40
Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy. (12946023)
2003
41
Involvement of hypocretins/orexins in sleep disorders and narcolepsy. (12792667)
2003
42
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. (12374492)
2002
43
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. (11723285)
2001
44
Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. (11558795)
2001
45
Narcolepsy and obesity: remission of severe cataplexy with sibutramine. (11152984)
2001
46
Increased REM density in narcolepsy-cataplexy and the polysymptomatic form of idiopathic hypersomnia. (11560185)
2001
47
Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. (11444684)
2001
48
Salivary secretions: narcolepsy and central nervous system stimulants. (9786638)
1998
49
Monoamine interactions in narcolepsy and hypersomnia: reanalysis. (2711094)
1989
50
Narcolepsy and idiopthic hypersomnia: biogenic amines and related compounds in CSF. (6890168)
1982

Genetic Variations for Narcolepsy

Expression for genes affiliated with Narcolepsy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Narcolepsy

Search GEO for disease gene expression data for Narcolepsy.

Pathways for genes affiliated with Narcolepsy

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Narcolepsy

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Narcolepsy according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1acetylcholine45 50 29 11 2415.4MOG, DRD1, DRD2, HCRT, HCRTR1, HCRTR2
2norepinephrine45 11 2413.4HCRTR2, HCRT, DRD2, DRD1, TNFRSF1B, LSL
3acth4511.3HCRTR2, HCRTR1, HCRT, TNFRSF1B, LSL
4c-peptide4511.3LSL, TNFRSF1B, HLA-DRB1, HCRT
5clozapine45 29 50 1114.3DRD2, DRD1, TNFRSF1B, LSL
6haloperidol45 29 2 50 1115.3LSL, DRD1, DRD2, HCRT
7dopamine45 29 11 2414.2DRD1, DRD2, HCRT, HCRTR1, CLOCK
8methylphenidate45 50 1113.2DRD1, DRD2, HCRT
9quetiapine45 50 29 11 2415.1LSL, DRD1, DRD2
10adenylate4511.1HCRTR1, HCRT, DRD2, DRD1, TNFRSF1B
11act-0785732911.1HCRTR1, HCRTR2
12risperidone29 45 50 60 11 2416.1LSL, DRD1, DRD2
13amphetamine45 1112.1HCRT, DRD2, DRD1
141-(2-bromo-phenyl)-3-((4s,5s)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea2911.1HCRTR2, HCRTR1
15[3h]sb-6740422911.1HCRTR2, HCRTR1
16sb-3348672911.1HCRTR2, HCRTR1
17sb-4081242911.1HCRTR2, HCRTR1
18skf 383934511.1DRD2, DRD1
19Acetophenazine1111.1DRD2, DRD1
20olanzapine50 45 29 11 2415.1DRD2, DRD1, LSL
211-(2,4-dibromo-phenyl)-3-((4s,5s)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea2911.1HCRTR1, HCRTR2
22orexin-b2911.1HCRTR2, HCRTR1
23orexin-a2911.1HCRTR2, HCRTR1
24[ala11, d-leu15]orexin-b2911.1HCRTR2, HCRTR1
25mk-60962911.0HCRTR2, HCRTR1
26sb-6498682911.0HCRTR1, HCRTR2
27suvorexant2911.0HCRTR1, HCRTR2
28Carphenazine1111.0DRD2, DRD1
29Thiethylperazine1111.0DRD2, DRD1
30eedq4511.0DRD2, DRD1
31cis flupentixol2911.0DRD2, DRD1
32eticlopride29 4512.0DRD2, DRD1
33Triflupromazine1111.0DRD1, DRD2
34opiate4511.0HCRT, DRD2, DRD1
35(+)-butaclamol29 4512.0DRD1, DRD2
36sch 233904511.0DRD1, DRD2
37zuclopenthixol45 50 1112.9DRD1, DRD2
38Thioproperazine1110.9DRD1, DRD2
39Acepromazine1110.9DRD1, DRD2
40loxapine29 45 1112.9DRD1, DRD2
41lithium45 50 11 2413.9LSL, DRD1, CLOCK
42thiothixene29 1111.9DRD1, DRD2
43d amphetamine4510.9DRD1, DRD2
44flupenthixol45 50 1112.8DRD2, DRD1
45minaprine45 1111.8DRD2, DRD1
46Pipotiazine1110.7DRD2, DRD1
47rotigotine45 29 1112.6DRD1, DRD2
48Chlorprothixene1110.6DRD2, DRD1
49raclopride45 2911.5DRD1, DRD2
50amoxapine45 29 1112.3DRD2, DRD1

GO Terms for genes affiliated with Narcolepsy

Sources:
16Gene Ontology
See all sources

Biological processes related to Narcolepsy according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.2NPTX2, ATXN3, HCRT, HCRTR1, HCRTR2
2feeding behaviorGO:00763111.0HCRTR2, HCRTR1, DRD2
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.9DRD2, DRD1
4cerebral cortex GABAergic interneuron migrationGO:02185310.9DRD2, DRD1
5peristalsisGO:03043210.9DRD2, DRD1
6phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.9DRD2, DRD1
7neuropeptide signaling pathwayGO:00721810.8HCRTR2, HCRTR1, HCRT
8dopamine metabolic processGO:04241710.8DRD1, DRD2
9synaptic transmission, dopaminergicGO:00196310.8DRD2, DRD1
10behavioral response to cocaineGO:04814810.8DRD2, DRD1
11prepulse inhibitionGO:06013410.7DRD1, DRD2
12grooming behaviorGO:00762510.6DRD2, DRD1
13temperature homeostasisGO:00165910.6DRD2, DRD1
14circadian regulation of gene expressionGO:03292210.5CLOCK, DRD2
15elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, DRD1

Molecular functions related to Narcolepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.6DRD2, DRD1
2orexin receptor activityGO:01649910.3HCRTR2, HCRTR1

Products for genes affiliated with Narcolepsy

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Sources for Narcolepsy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet