Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases
Aliases & Descriptions for Narcolepsy:
Orphanet epidemiological data:51
Prevalence: 1-5/10000 (Europe); Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy
narcolepsy without cataplexy:
Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases
ICD10: 28 27
Rare neurological diseases
NIH Rare Diseases:45 Narcolepsy is a chronic brain disorder that involves poor control of sleep-wake cycles. people with narcolepsy have episodes of extreme daytime sleepiness and sudden, irresistible bouts of sleep (called "sleep attacks") that can occur at any time, and may last from seconds or minutes. other signs and symptoms may include cataplexy (a sudden loss of muscle tone that makes a person go limp or unable to move); vivid dream-like images or hallucinations; and/or total paralysis just before falling asleep or after waking-up. narcolepsy may have several causes, the most common being low levels of the neurotransmitter hypocretin (for various possible reasons). the disorder is usually sporadic but some cases are familial. there is no cure, but some symptoms can be managed with medicines and lifestyle changes. last updated: 4/27/2015
MalaCards based summary: Narcolepsy, also known as narcolepsy-cataplexy syndrome, is related to obstructive sleep apnea and narcolepsy 1, and has symptoms including hallucinations, muscle weakness and memory impairment. An important gene associated with Narcolepsy is HCRT (Hypocretin (Orexin) Neuropeptide Precursor), and among its related pathways are CTLA4 Signaling and Staphylococcus aureus infection. The drugs amphetamine and dextroamphetamine sulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and lung, and related mouse phenotypes are nervous system and behavior/neurological.
Disease Ontology:10 A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.
Genetics Home Reference:23 Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.
NINDS:46 Narcolepsy is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. At various times throughout the day, people with narcolepsy experience irresistable bouts of
Wikipedia:68 Narcolepsy is a chronic neurological disorder involving the loss of the brain\'s ability to regulate... more...
Symptoms:51 (show all 11)
HPO human phenotypes related to Narcolepsy:(show all 9)
UMLS symptoms related to Narcolepsy:sleeplessness, sluggishness, excessive daytime somnolence, hallucinations, hypnagogic, sleep disturbances, hemiplegia
Drugs for Narcolepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 86)
Interventional clinical trials:(show top 50) (show all 83)
Search NIH Clinical Center for Narcolepsy
Inferred drug relations via UMLS65/NDF-RT43:
MalaCards organs/tissues related to Narcolepsy:33
Brain, Eye, Lung, Heart, Liver, T cells, Prostate
Articles related to Narcolepsy:(show top 50) (show all 754)
Search GEO for disease gene expression data for Narcolepsy.
Pathways related to Narcolepsy according to GeneCards Suite gene sharing:
Cellular components related to Narcolepsy according to GeneCards Suite gene sharing:
Biological processes related to Narcolepsy according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet