MCID: NRC018
MIFTS: 17

Narcolepsy 6

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Narcolepsy 6

MalaCards integrated aliases for Narcolepsy 6:

Name: Narcolepsy 6 54 13
Narcolepsy 6, Susceptibility to 29

Classifications:



External Ids:

OMIM 54 614223

Summaries for Narcolepsy 6

MalaCards based summary : Narcolepsy 6, is also known as narcolepsy 6, susceptibility to. An important gene associated with Narcolepsy 6 is NRCLP6 (Narcolepsy 6). The drugs Sodium oxybate and Pharmaceutical Solutions have been mentioned in the context of this disorder.

Description from OMIM: 614223

Related Diseases for Narcolepsy 6

Symptoms & Phenotypes for Narcolepsy 6

Clinical features from OMIM:

614223

Drugs & Therapeutics for Narcolepsy 6

Drugs for Narcolepsy 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium oxybate Approved Phase 4,Phase 3 502-85-2 5360545
2 Pharmaceutical Solutions Phase 4,Phase 3
3
Armodafinil Approved, Investigational Phase 3 112111-43-0
4
Modafinil Approved, Investigational Phase 3 68693-11-8 4236
5
Dopamine Approved Phase 2, Phase 3,Phase 1 51-61-6, 62-31-7 681
6
Methylphenidate Approved, Investigational Phase 2, Phase 3 113-45-1 4158
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
8
Pyridoxal Approved, Nutraceutical Phase 3 66-72-8 1050
9
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
10 Central Nervous System Stimulants Phase 3,Phase 2,Phase 1
11 Cytochrome P-450 CYP3A Inducers Phase 3
12 Wakefulness-Promoting Agents Phase 3
13 Adjuvants, Anesthesia Phase 3
14 Anesthetics Phase 3
15 Anesthetics, General Phase 3
16 Anesthetics, Intravenous Phase 3
17 Central Nervous System Depressants Phase 3
18 Dopamine Agents Phase 2, Phase 3,Phase 1
19 Dopamine Uptake Inhibitors Phase 2, Phase 3
20 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
21 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
22 Micronutrients Phase 3
23 Trace Elements Phase 3
24 Vitamin B 6 Phase 3
25 Vitamin B Complex Phase 3
26 Vitamins Phase 3
27 Folate Nutraceutical Phase 3
28 Vitamin B9 Nutraceutical Phase 3
29
Adenosine Approved, Investigational Phase 1, Phase 2 58-61-7 60961
30
Norepinephrine Approved Phase 1, Phase 2 51-41-2 439260
31
Caffeine Approved, Nutraceutical Phase 1, Phase 2 58-08-2 2519
32 Analgesics Phase 1, Phase 2
33 Anti-Arrhythmia Agents Phase 1, Phase 2
34 Anticoagulants Phase 1, Phase 2
35 Caffeine citrate Phase 1, Phase 2
36 Calcium, Dietary Phase 1, Phase 2
37 Chelating Agents Phase 1, Phase 2
38 Peripheral Nervous System Agents Phase 1, Phase 2
39 Phosphodiesterase Inhibitors Phase 1, Phase 2
40 Purinergic P1 Receptor Antagonists Phase 1, Phase 2
41
Serotonin Phase 1, Phase 2 50-67-9 5202
42 Vasodilator Agents Phase 1, Phase 2
43 Citrate Nutraceutical Phase 1, Phase 2
44
Citric Acid Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 Observational Study to Evaluate Risks of Side Effects, Drug Abuse and Dependence in Patients Who Received Xyrem ® on Prescription Completed NCT00244465 Phase 4
2 Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy Completed NCT00107796 Phase 3 Modafinil
3 Assess the Safety and Effectiveness of PROVIGIL Treatment in Children and Adolescents With Excessive Sleepiness Completed NCT00214968 Phase 3 Modafinil
4 PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome Completed NCT00107848 Phase 3 Modafinil
5 Trial of Xyrem® (Sodium Oxybate) for the Treatment of Narcolepsy Completed NCT00132873 Phase 3 Xyrem (sodium oxybate) oral solution
6 Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy Completed NCT00066170 Phase 3 Xyrem;Xyrem Placebo;Modafinil at established dose;Modafinil (Placebo)
7 Methylphenidate to Improve Balance and Walking in MS Completed NCT01896700 Phase 2, Phase 3 Methylphenidate;Placebo
8 Modafinil in Cancer Related Fatigue Completed NCT01440621 Phase 3 Modafinil;Pyridoxine
9 Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy Recruiting NCT02720744 Phase 3 Sodium Oxybate;Placebo
10 Modafinil to Treat Fatigue in Post-Polio Syndrome Terminated NCT00067496 Phase 3 Modafinil
11 Efficacy and Safety of Pitolisant in Pediatric Narcoleptic Patients With or Without Cataplexy, Double-blind Study Followed by a Prolonged Open-label Period Recruiting NCT02611687 Phase 2 pitolisant;Placebo
12 The Effect of Caffeine on the Narcoleptic Patients Recruiting NCT02832336 Phase 1, Phase 2 Vivarin;Fiber
13 Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition Unknown status NCT00484757 Orexine A
14 Body Weight Regulation in Patients With Narcolepsy Completed NCT00283894
15 Modafinil in Multiple Sclerosis Completed NCT00142402 Modafinil
16 Sleep and Memory in Children Recruiting NCT02785328
17 The Nuvigil and Provigil Pregnancy Registry Recruiting NCT01792583 Modafinil/armodafinil
18 Metabolism Characteristics in the Children With Narcolepsy Recruiting NCT02799849
19 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
20 Understanding Sleep in Hospitalized Older Patients Recruiting NCT01057823

Search NIH Clinical Center for Narcolepsy 6

Genetic Tests for Narcolepsy 6

Genetic tests related to Narcolepsy 6:

id Genetic test Affiliating Genes
1 Narcolepsy 6, Susceptibility to 29

Anatomical Context for Narcolepsy 6

Publications for Narcolepsy 6

Variations for Narcolepsy 6

Expression for Narcolepsy 6

Search GEO for disease gene expression data for Narcolepsy 6.

Pathways for Narcolepsy 6

GO Terms for Narcolepsy 6

Sources for Narcolepsy 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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