MCID: NSL022
MIFTS: 30

Nasal Cavity Disease

Categories: Respiratory diseases

Aliases & Classifications for Nasal Cavity Disease

MalaCards integrated aliases for Nasal Cavity Disease:

Name: Nasal Cavity Disease 12 14
Disorder of Nasal Cavity 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2163
NCIt 46 C27102
UMLS 69 C0339820

Summaries for Nasal Cavity Disease

MalaCards based summary : Nasal Cavity Disease, also known as disorder of nasal cavity, is related to cytokine deficiency and loeffler endocarditis. An important gene associated with Nasal Cavity Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Allograft rejection and Jak-STAT signaling pathway (KEGG). Related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 The nasal cavity (nasal fossa, or nasal passage) is a large air filled space above and behind the nose... more...

Related Diseases for Nasal Cavity Disease

Diseases related to Nasal Cavity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 10.6 IL13 IL5
2 loeffler endocarditis 10.6 IL5 RNASE3
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL13 IL5
4 pemphigoid gestationis 10.5 CCL11 IL5
5 atopic keratoconjunctivitis 10.5 IL4 IL5 RNASE3
6 intrinsic asthma 10.5 IL4 IL5 RNASE3
7 paragonimiasis 10.5 IL13 IL5 RNASE3
8 nut allergy 10.5 IL13 IL5 TLR9
9 tropical endomyocardial fibrosis 10.5 IL10 IL4
10 blepharoconjunctivitis 10.5 CCL11 IL4 RNASE3
11 vernal conjunctivitis 10.5 IL4 MS4A2 RNASE3
12 hyperlucent lung 10.5 IL10 IL4
13 eosinophilic gastroenteritis 10.5 CCL11 IL5 RNASE3
14 intestinal schistosomiasis 10.5 IL13 IL4 IL5
15 chronic tic disorder 10.5 IL13 IL4 IL5
16 strongyloidiasis 10.5 CCL11 IL13 IL5
17 enterobiasis 10.5 IL13 IL4 IL5
18 prurigo nodularis 10.5 RNASE3 TAC1
19 sezary's disease 10.5 IL4 IL5 TLR9
20 vasomotor rhinitis 10.4 RNASE3 TAC1 TLR9
21 sinusitis 10.4 CYSLTR1 IL5 RNASE3
22 ascaridiasis 10.4 IL10 IL13
23 respiratory syncytial virus infectious disease 10.4 IL13 IL5
24 cough variant asthma 10.4 IL4 IL5 RNASE3 TRPV1
25 cow milk allergy 10.4 IL10 IL5 RNASE3
26 eye lymphoma 10.4 IL10 TLR9
27 tungiasis 10.4 IL10 IL4
28 endomyocardial fibrosis 10.4 IL10 IL4
29 somatoform disorder 10.4 IL4 TAC1 TRPV1
30 interstitial cystitis 10.4 IL4 TAC1 TRPV1
31 coccidiosis 10.4 IL10 IL4 TLR9
32 genital herpes 10.4 IL10 IL4 TLR9
33 bullous pemphigoid 10.4 CCL11 IL5 RNASE3
34 churg-strauss syndrome 10.4 IL10 IL5 RNASE3
35 extrinsic cardiomyopathy 10.4 IL10 IL4 TLR9
36 immunoglobulin a deficiency 1 10.4 IL10 IL4
37 opportunistic mycosis 10.4 IL10 IL4 TLR9
38 beta-lactam allergy 10.4 IL10 IL13 IL4
39 inflammatory bowel disease 4 10.4 IL13 IL4 IL5 RNASE3
40 latex allergy 10.4 IL13 IL4 IL5 RNASE3
41 urinary schistosomiasis 10.4 IL13 IL4 IL5 RNASE3
42 mouth disease 10.4 IL10 TLR9 TRPV1
43 physical urticaria 10.4 MS4A2 TRPV1
44 filariasis 10.4 IL10 IL5 TLR9
45 paracoccidioidomycosis 10.4 IL10 IL4 IL5
46 primary bacterial infectious disease 10.3 IL10 IL4 TLR9
47 toxoplasmosis 10.3 IL10 IL4 TLR9
48 scabies 10.3 CCL11 IL10
49 esophageal disease 10.3 IL13 IL5 TRPV1 TSLP
50 eosinophilic pneumonia 10.3 CCL11 IL13 IL5 RNASE3

Graphical network of the top 20 diseases related to Nasal Cavity Disease:



Diseases related to Nasal Cavity Disease

Symptoms & Phenotypes for Nasal Cavity Disease

MGI Mouse Phenotypes related to Nasal Cavity Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 TLR9 IL10 TSLP IL13 IL4 CCL11
2 homeostasis/metabolism MP:0005376 9.97 ICAM1 TLR9 TRPV1 IL10 TSLP IL13
3 digestive/alimentary MP:0005381 9.92 TLR9 IL10 TSLP IL13 IL4 CHD7
4 immune system MP:0005387 9.8 TLR9 IL10 TRPV1 TSLP IL13 IL4
5 respiratory system MP:0005388 9.23 IL10 TSLP IL13 IL4 CCL11 CHD7

Drugs & Therapeutics for Nasal Cavity Disease

Search Clinical Trials , NIH Clinical Center for Nasal Cavity Disease

Genetic Tests for Nasal Cavity Disease

Anatomical Context for Nasal Cavity Disease

Publications for Nasal Cavity Disease

Variations for Nasal Cavity Disease

Expression for Nasal Cavity Disease

Search GEO for disease gene expression data for Nasal Cavity Disease.

Pathways for Nasal Cavity Disease

Pathways related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 CCL11 ICAM1 IL10 IL13 IL4 IL5
2
Show member pathways
12.3 IL10 IL13 IL4 IL5 TSLP
3
Show member pathways
12.22 CCL11 IL13 IL4 IL5
4
Show member pathways
12.09 IL10 IL13 IL4 IL5
5 11.92 IL10 IL4 IL5 PTGDR2
6 11.89 CCL11 ICAM1 IL10 IL13 IL4
7 11.76 ICAM1 IL13 IL4 IL5
8 11.61 CCL11 IL10 IL4 IL5
9 11.6 CCL11 IL13 IL4 IL5
10 11.45 ICAM1 IL10 TLR9
11 11.45 ICAM1 IL10 IL13 IL4
12 11.37 ICAM1 IL10 IL4 IL5 TLR9
13 11.29 ICAM1 IL10 TLR9
14 11.21 IL13 IL4 IL5 TSLP
15 11.16 CCL11 IL10 IL13 IL4 IL5
16 11.15 IL10 IL13 IL4 IL5
17 11.04 IL10 IL13 IL4 IL5
18 11.02 CCL11 IL10 IL13 IL4 IL5
19 11 IL10 IL13 IL4 IL5 PTGDR2 TSLP
20 10.9 CCL11 IL10 IL13 IL4 IL5
21 10.73 IL13 IL4 IL5

GO Terms for Nasal Cavity Disease

Cellular components related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL11 IL10 IL13 IL4 IL5 NPS
2 external side of plasma membrane GO:0009897 9.46 ICAM1 IL13 MS4A2 TRPV1
3 extracellular space GO:0005615 9.32 CCL11 ICAM1 IL10 IL13 IL4 IL5

Biological processes related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.85 ICAM1 IL10 IL13 TAC1
2 regulation of receptor activity GO:0010469 9.8 CCL11 IL10 IL13 IL4 IL5 TSLP
3 immune response GO:0006955 9.8 CCL11 IL10 IL13 IL4 IL5 MS4A2
4 chemotaxis GO:0006935 9.78 CCL11 CYSLTR1 IL4 PTGDR2
5 neuropeptide signaling pathway GO:0007218 9.67 CYSLTR1 NPS PTGDR2 TAC1
6 positive regulation of macrophage activation GO:0043032 9.62 IL10 IL13
7 microglial cell activation GO:0001774 9.61 IL13 TRPV1
8 positive regulation of synaptic transmission, GABAergic GO:0032230 9.61 NPS TAC1
9 response to molecule of bacterial origin GO:0002237 9.6 IL10 TLR9
10 cellular response to alkaloid GO:0071312 9.59 ICAM1 TRPV1
11 positive regulation of interleukin-13 production GO:0032736 9.58 IL4 TSLP
12 eosinophil chemotaxis GO:0048245 9.57 CCL11 HRH1
13 positive regulation of immunoglobulin production GO:0002639 9.56 IL13 TLR9
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL10 IL4
15 positive regulation of action potential GO:0045760 9.52 NPS TAC1
16 type 2 immune response GO:0042092 9.51 IL10 IL4
17 negative regulation of interleukin-8 production GO:0032717 9.49 IL10 TLR9
18 queuosine biosynthetic process GO:0008616 9.46 PDC PDCL
19 positive regulation of B cell proliferation GO:0030890 9.46 IL13 IL4 IL5 TLR9
20 regulation of isotype switching GO:0045191 9.43 IL10 IL4
21 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
22 inflammatory response GO:0006954 9.28 CCL11 HRH1 IL10 IL13 IL5 MS4A2
23 negative regulation of endothelial cell apoptotic process GO:2000352 9.26 ICAM1 IL10 IL13 IL4
24 G-protein coupled receptor signaling pathway GO:0007186 10.13 CCL11 CYSLTR1 HRH1 NPS PDC PTGDR2

Molecular functions related to Nasal Cavity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL11 IL10 IL13 IL4 IL5 TSLP
2 queuine tRNA-ribosyltransferase activity GO:0008479 8.96 PDC PDCL

Sources for Nasal Cavity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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