MCID: NSP001
MIFTS: 63

Nasopharynx Carcinoma malady

Rare diseases, Cancer diseases, Respiratory diseases categories

Summaries for Nasopharynx Carcinoma

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OMIM:46 Nasopharyngeal carcinoma is a multifactorial malignancy associated with both genetic and environmental factors. The... (161550) more...

MalaCards based summary: Nasopharynx Carcinoma, also known as nasopharyngeal carcinoma, is related to infectious mononucleosis and cervical adenocarcinoma, and has symptoms including neoplasm, polygenic inheritance and neoplasia of the nasopharynx. An important gene associated with Nasopharynx Carcinoma is TP53 (tumor protein p53), and among its related pathways are Thyroid cancer and Oncogene Induced Senescence. The compounds acnu and hpvs have been mentioned in the context of this disorder. Affiliated tissues include the nasopharynx, skin and brain.

Disease Ontology:9 A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

Wikipedia:64 Nasopharynx cancer or nasopharyngeal carcinoma (NPC) is the most common cancer originating in the... more...

Description from OMIM:46 607107

Aliases & Classifications for Nasopharynx Carcinoma

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Sources:
9Disease Ontology, 42NIH Rare Diseases, 23GTR, 46OMIM, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 28ICD9CM, 39NCIt, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Nasopharynx Carcinoma, Aliases & Descriptions:

Name: Nasopharynx Carcinoma 9 11
Nasopharyngeal Carcinoma 9 42 46 44 48 61
Malignant Neoplasm of Other Specified Sites of Nasopharynx 9 61
Primary Malignant Neoplasm of Anterior Wall of Nasopharynx 9 61
Malignant Neoplasm of Other Specified Site of Nasopharynx 9 61
Malignant Neoplasm of Posterior Wall of Nasopharynx 9 61
Malignant Neoplasm of Anterior Wall of Nasopharynx 9 61
Malignant Neoplasm of Superior Wall of Nasopharynx 9 61
Malignant Neoplasm of Lateral Wall of Nasopharynx 9 61
Malignant Tumor of Posterior Wall of Nasopharynx 9 61
Malignant Tumor of Anterior Wall of Nasopharynx 9 61
Malignant Tumor of Lateral Wall of Nasopharynx 9 61
Malignant Neoplasm of Roof of Nasopharynx 9 61
 
Malignant Neoplasm of Nasopharyngeal Wall 9 61
Malignant Tumor of Roof of Nasopharynx 9 61
Malignant Neoplasm of Nasopharynx 9 61
Malignant Tumor of Nasopharynx 9 61
Nasopharyngeal Cancer 42 23
Malignant Neoplasm of Posterior Wall of Nasopharynx Nos 9
Malignant Neoplasm of Anterior Wall of Nasopharynx Nos 9
Malignant Neoplasm of Lateral Wall of Nasopharynx Nos 9
Malignant Neoplasm of Nasopharyngeal Wall Nos 9
Malignant Neoplasm of Nasopharynx Nos 9
Malignant Nasopharyngeal Tumor 9
Cancer of Nasopharynx 61
Nasopharynx Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
nasopharyngeal carcinoma:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Variable


External Ids:

Disease Ontology9 DOID:9261
ICD9CM28 147, 147.9
NCIt39 C9321
MESH via Orphanet35 C538339
ICD10 via Orphanet27 C11
UMLS via Orphanet62 C2931822

Related Diseases for Nasopharynx Carcinoma

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Diseases related to Nasopharynx Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1infectious mononucleosis30.3GOLIM4, PDLIM7, CD79A
2cervical adenocarcinoma30.2CDKN2A, RASSF1
3papilloma30.0CDKN2A, TP53, RASSF1
4squamous cell carcinoma of the head and neck30.0RASSF1, TP53, CDKN2A
5laryngeal squamous cell carcinoma29.9CDKN2A, CDH1, TP53
6esophageal cancer29.9CDKN2A, TP53, CDH1
7burkitt's lymphoma29.9CD79A, TP53, PDLIM7, CDKN2A
8adenocarcinoma29.5CDH1, CDKN2A, RASSF1, ZMYND10, TP53
9lung cancer29.2CDH1, CDKN2A, RASSF1, ZMYND10, HLA-A, TP53
10nasopharyngitis11.5
11endotheliitis10.7
12hypoxia10.5
13choroid plexus papilloma10.4TP53
14actinic keratosis10.4TP53
15cranial nerve palsy10.4
16dermatomyositis10.4
17esophagitis10.4
18lymphoepithelioma-like carcinoma10.3
19otitis media10.3
20retinoblastoma10.3
21hepatitis10.2
22choanal atresia10.2
23keratinizing squamous cell carcinoma10.2
24allergic rhinitis10.2
25cervical adenitis10.2
26collagen disease10.2
27dermatitis10.2
28rhinitis10.2
29amyopathic dermatomyositis10.2
30ocular neuromyotonia10.2
31dysphagia10.2
32nasopharyngeal carcinoma 110.2
33nasopharyngeal carcinoma 210.2
34myokymia10.2
35bladder transitional cell carcinoma10.2CDH1, TP53
36oropharyngeal cancer, adult10.2CDKN2A, TP53
37nasopharyngeal cancer, childhood10.1
38stomach cancer10.1CDH1, TP53
39breast cancer, invasive ductal10.1CDH1, TP53
40ductal carcinoma in situ10.1CDH1, TP53
41li-fraumeni syndrome10.1CDKN2A, TP53
42breast ductal carcinoma10.1TP53, CDH1
43cervical squamous cell carcinoma10.1CDKN2A, RASSF1
44salivary gland adenoid cystic carcinoma10.1CDH1, RASSF1
45leukemia10.1
46renal cell carcinoma10.1
47sinusitis10.1
48myelitis10.1
49primary hyperparathyroidism10.1
50cervicitis10.1

Graphical network of the top 20 diseases related to Nasopharynx Carcinoma:



Diseases related to nasopharynx carcinoma

Symptoms for Nasopharynx Carcinoma

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Symptoms by clinical synopsis from OMIM:

161550

Clinical features from OMIM:

161550,607107

HPO human phenotypes related to Nasopharynx Carcinoma:

id Description Frequency HPO Source Accession
1 neoplasm HP:0002664
2 polygenic inheritance HP:0010982
3 neoplasia of the nasopharynx HP:0100630

Drugs & Therapeutics for Nasopharynx Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Nasopharynx Carcinoma

Search NIH Clinical Center for Nasopharynx Carcinoma

Genetic Tests for Nasopharynx Carcinoma

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Genetic tests related to Nasopharynx Carcinoma:

id Genetic test Affiliating Genes
1 Nasopharyngeal Carcinoma23

Anatomical Context for Nasopharynx Carcinoma

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MalaCards organs/tissues related to Nasopharynx Carcinoma:

32
Skin, Brain, Colon, Thyroid, Breast

FMA organs/tissues related to Nasopharynx Carcinoma:

15
The nasopharynx

Animal Models for Nasopharynx Carcinoma or affiliated genes

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Publications for Nasopharynx Carcinoma

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Articles related to Nasopharynx Carcinoma:

(show all 16)
idTitleAuthorsYear
1
Second primary malignant peripheral nerve sheath tumor of the paranasal sinuses after nasopharynx carcinoma. (25304136)
2014
2
Diagnosis of pediatric nasopharynx carcinoma after recurrent adenoidectomy. (24392236)
2013
3
Nasopharynx carcinoma: a rare primary for bilateral breast metastasis. (22778459)
2012
4
Anesthetic considerations in a child with a diagnosis of nasopharynx carcinoma who was on radiotherapy after induction chemotherapy with mucositis toxicities. (18673311)
2008
5
Pneumocephalus in nasopharynx carcinoma. (18195505)
2008
6
Nasopharynx carcinoma complicated with pneumocephalus. (16292487)
2006
7
A microcystic adnexal carcinoma in the auditory canal 15 years after radiotherapy of a 12-year-old boy with nasopharynx carcinoma. (15925985)
2005
8
QSAR of antineoplastics IV: Hansch analysis of N-(7-indolyl)benzenesulfonamides against KB human nasopharynx carcinoma, colon 38 murine adenocarcinoma and P388 murine leukemia cell lines. (11469750)
2001
9
The use of pilocarpine hydrochloride to prevent xerostomia in a child treated with high dose radiotherapy for nasopharynx carcinoma. (9861344)
1998
10
Syndrome of inappropriate secretion of antidiuretic hormone in nasopharynx carcinoma. (9260257)
1997
11
Factors influencing adjustment of patients suffering from nasopharynx carcinoma--implications for oncology social work. (9385710)
1997
12
Nasopharynx carcinoma: choice of treatment. (7558969)
1995
13
The detection of nasopharynx carcinoma in technetium-99m (V) dimercaptosuccinic acid SPECT imaging. (8386992)
1993
14
Primary hyperparathyroidism with triple cancers consisting of renal cell carcinoma, nasopharynx carcinoma and thyroid carcinoma. (839605)
1977
15
Intramedullary cervical cord metastasis from a nasopharynx carcinoma. (4852541)
1974
16
Sensitivity to irradiation of the brain stem. Irradiation myelitis in the treatment of a nasopharynx carcinoma. (4207294)
1974

Variations for Nasopharynx Carcinoma

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Clinvar genetic disease variations for Nasopharynx Carcinoma:

7
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.839G> C (p.Arg280Thr)single nucleotide variantPathogenicrs121912660GRCh37Chr 17, 7577099: 7577099

Expression for genes affiliated with Nasopharynx Carcinoma

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Expression patterns in normal tissues for genes affiliated with Nasopharynx Carcinoma

Search GEO for disease gene expression data for Nasopharynx Carcinoma.

Pathways for genes affiliated with Nasopharynx Carcinoma

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Pathways related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CDH1, TP53
29.9TP53, CDKN2A
39.9TP53, CDKN2A
4
Show member pathways
9.9TP53, CDKN2A
5
Show member pathways
Cell cycle37
9.6CDH1, CDKN2A, TP53
69.5CDKN2A, TP53, HLA-A
79.5CDKN2A, TP53, HLA-A
89.3TP53, RASSF1, CDKN2A, CDH1
9
Show member pathways
Signaling Pathways in Glioblastoma37
9.3CDH1, CDKN2A, RASSF1, TP53
10
Show member pathways
Wnt Signaling Pathway NetPath37
9.1CDH1, BRD7, TP53

Compounds for genes affiliated with Nasopharynx Carcinoma

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Compounds related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1acnu4410.3CDKN2A, TP53
2hpvs4410.2CDKN2A, TP53
3aristolochic acid44 311.2CDH1, TP53
4olomoucine44 1211.2CDKN2A, TP53
5temozolomide44 1211.1TP53, CDKN2A
6hmba4410.1CDKN2A, TP53
7aflatoxin b144 2511.1CDKN2A, TP53
8isoniazid44 50 1212.1CDKN2A, CD79A
9nocodazole44 1211.0TP53, CD79A, CDH1
10bcnu4410.0TP53, CDKN2A
11depsipeptide4410.0TP53, CDKN2A, CDH1
12irinotecan44 50 1212.0TP53, CDKN2A, CDH1
13thymidylate449.9CDH1, CDKN2A, TP53
14indole-3-carbinol449.9CDH1, TP53
15sodium bisulfite449.9CDH1, CDKN2A, RASSF1
16adriamycin449.9TP53, CDKN2A, CDH1
17docetaxel44 50 60 1212.9TP53, CDKN2A, CDH1
18egcg449.9TP53, CDKN2A, CDH1
19p00001449.9CDH1, CDKN2A
20cytosine44 2510.9CDH1, CDKN2A, RASSF1
21mg 13244 6010.9CDH1, CDKN2A, TP53
22nickel44 2510.7CDH1, CDKN2A
235-methylcytosine44 2510.7TP53, RASSF1, CDKN2A, CDH1
24o6-methylguanine449.7CDH1, CDKN2A, RASSF1, TP53
25crcs449.7TP53, RASSF1, CDKN2A, CDH1
26n acetylcysteine449.7CDH1, CD79A, CDKN2A, TP53
27methotrexate50 44 1211.7CDKN2A, CD79A, CDH1
28paraffin449.7TP53, CDKN2A, CD79A, CDH1
29azathioprine44 3 50 1212.6RASSF1, CDKN2A, CD79A, CDH1
30folate449.6CDH1, CD79A, CDKN2A, RASSF1
31agar449.6RASSF1, CDKN2A, CD79A, CDH1
325fluorouracil449.6CDH1, CDKN2A, TP53, HLA-A
33cisplatin44 50 60 1212.6TP53, RASSF1, CDKN2A, CDH1
34zonisamide44 50 1211.5CD79A, HLA-A
35estrogen449.3CDH1, CD79A, CDKN2A, RASSF1, TP53
36retinoic acid44 2510.3CDH1, CD79A, CDKN2A, RASSF1, TP53
37arginine449.3CDH1, CD79A, CDKN2A, TP53, HLA-A
38oligonucleotide449.2HLA-A, TP53, RASSF1, CDKN2A
39alanine449.2HLA-A, RASSF1, CDKN2A, CD79A, CDH1
405-aza-2deoxycytidine449.1CDH1, CDKN2A, RASSF1, ZMYND10, TP53, HLA-A

GO Terms for genes affiliated with Nasopharynx Carcinoma

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Cellular components related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.6CDKN2A, TP53
2nucleusGO:0056347.1TP53, TMEM8B, BRD7, CCDC19, PDLIM7, RASSF1

Biological processes related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.9CDKN2A, TP53
2Ras protein signal transductionGO:0072659.7CDKN2A, RASSF1, TP53
3positive regulation of cell cycle arrestGO:0711589.6CDKN2A, TP53
4cell cycle arrestGO:0070509.5TP53, RASSF1, CDKN2A
5positive regulation of transcription, DNA-templatedGO:0458938.8CDH1, CDKN2A, BRD7, TP53

Molecular functions related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.8CDKN2A, TP53
2p53 bindingGO:0020399.1CDKN2A, BRD7, TP53
3transcription factor bindingGO:0081349.1CDKN2A, BRD7, TP53
4protein bindingGO:0055156.3BRD7, TMEM8B, TP53, HLA-A, ZMYND10, COLQ

Products for genes affiliated with Nasopharynx Carcinoma

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  • Antibodies
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  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Nasopharynx Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet