MCID: NSP001
MIFTS: 62

Nasopharynx Carcinoma malady

Rare diseases, Cancer diseases, Respiratory diseases categories
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Summaries for Nasopharynx Carcinoma

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Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A respiratory system cancer that is located in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

MalaCards: Nasopharynx Carcinoma, also known as nasopharyngeal carcinoma, is related to burkitt's lymphoma and infectious mononucleosis. An important gene associated with Nasopharynx Carcinoma is TP53 (tumor protein p53), and among its related pathways are Thyroid cancer and Oncogene Induced Senescence. The compounds acnu and hpvs have been mentioned in the context of this disorder. Affiliated tissues include the nasopharynx, skin and brain.

Wikipedia:65 Nasopharynx cancer or nasopharyngeal carcinoma (NPC) is the most common cancer originating in the... more...

Description from OMIM:47 161550,607107

Aliases & Classifications for Nasopharynx Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 43NIH Rare Diseases, 47OMIM, 45Novoseek, 49Orphanet, 62UMLS, 22GTR, 58SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
nasopharyngeal carcinoma:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Variable


Aliases & Descriptions:

nasopharynx carcinoma 8 10
nasopharyngeal carcinoma 8 43 47 45 49 62
malignant neoplasm of nasopharynx 8 62
nasopharyngeal cancer 43 22
malignant neoplasm of other specified sites of nasopharynx 8
primary malignant neoplasm of anterior wall of nasopharynx 8
malignant neoplasm of other specified site of nasopharynx 8
malignant neoplasm of posterior wall of nasopharynx nos 8
malignant neoplasm of anterior wall of nasopharynx nos 8
malignant neoplasm of lateral wall of nasopharynx nos 8
malignant neoplasm of posterior wall of nasopharynx 8
malignant neoplasm of anterior wall of nasopharynx 8
malignant neoplasm of superior wall of nasopharynx 8
malignant neoplasm of lateral wall of nasopharynx 8
malignant tumor of posterior wall of nasopharynx 8
malignant tumor of anterior wall of nasopharynx 8
malignant tumor of lateral wall of nasopharynx 8
malignant neoplasm of nasopharyngeal wall nos 8
malignant neoplasm of roof of nasopharynx 8
malignant neoplasm of nasopharyngeal wall 8
malignant tumor of roof of nasopharynx 8
malignant neoplasm of nasopharynx nos 8
malignant nasopharyngeal tumor 8
malignant tumor of nasopharynx 8
cancer of nasopharynx 62
nasopharynx cancer 8


External Ids:

Disease Ontology8 DOID:9261
ICD9CM27 147, 147.9
NCIt40 C9321
ICD10 via Orphanet26 C11
SNOMED-CT via Orphanet59 449248000
UMLS via Orphanet63 C2931822
MESH via Orphanet36 C538339

Related Diseases for Nasopharynx Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nasopharynx Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1burkitt's lymphoma30.2CD79A, TP53, PDLIM7, CDKN2A
2infectious mononucleosis30.1GOLIM4, PDLIM7, CD79A
3cervical adenocarcinoma30.1CDKN2A, RASSF1
4papilloma30.0CDKN2A, TP53, RASSF1
5laryngeal squamous cell carcinoma30.0CDKN2A, CDH1, TP53
6esophageal cancer30.0CDKN2A, TP53, CDH1
7adenocarcinoma29.9CDH1, CDKN2A, RASSF1, ZMYND10, TP53
8squamous cell carcinoma of the head and neck29.9TP53, CDKN2A, CDH1, RASSF1
9lung cancer29.8CDH1, CDKN2A, RASSF1, ZMYND10, HLA-A, TP53
10nasopharyngitis11.5
11endotheliitis10.7
12hypoxia10.5
13cranial nerve palsy10.4
14dermatomyositis10.4
15esophagitis10.3
16lymphoepithelioma-like carcinoma10.3
17otitis media10.3
18retinoblastoma10.3
19choanal atresia10.2
20keratinizing squamous cell carcinoma10.2
21allergic rhinitis10.2
22cervical adenitis10.2
23collagen disease10.2
24dermatitis10.2
25hepatitis10.2
26rhinitis10.2
27amyopathic dermatomyositis10.2
28ocular neuromyotonia10.2
29dysphagia10.2
30nasopharyngeal carcinoma 110.2
31nasopharyngeal carcinoma 210.2
32myokymia10.2
33nasopharyngeal cancer, childhood10.1
34choroid plexus papilloma10.1TP53
35actinic keratosis10.1TP53
36myelitis10.1
37primary hyperparathyroidism10.1
38cervicitis10.1
39hyperparathyroidism10.1
40leukemia10.1
41renal cell carcinoma10.1
42thyroiditis10.1
43bladder transitional cell carcinoma10.0CDH1, TP53
44oropharyngeal cancer, adult10.0CDKN2A, TP53
45stomach cancer10.0CDH1, TP53
46breast cancer, invasive ductal10.0CDH1, TP53
47ductal carcinoma in situ10.0CDH1, TP53
48li-fraumeni syndrome10.0CDKN2A, TP53
49cervical squamous cell carcinoma10.0CDKN2A, RASSF1
50nasopharyngeal teratoma10.0

Graphical network of the top 20 diseases related to Nasopharynx Carcinoma:



Diseases related to nasopharynx carcinoma

Symptoms for Nasopharynx Carcinoma

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Sources:
47OMIM
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Symptoms by clinical synopsis from OMIM:

161550

Clinical features from OMIM:

161550,607107

Drugs & Therapeutics for Nasopharynx Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Nasopharynx Carcinoma

Search NIH Clinical Center for Nasopharynx Carcinoma

Genetic Tests for Nasopharynx Carcinoma

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Sources:
22GTR
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Genetic tests related to Nasopharynx Carcinoma:

id Genetic test Affiliating Genes
1 Nasopharyngeal Carcinoma22

Anatomical Context for Nasopharynx Carcinoma

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Nasopharynx Carcinoma:

33
Skin, Brain, Colon, Thyroid, Breast

FMA organs/tissues related to Nasopharynx Carcinoma:

14
The nasopharynx

Animal Models for Nasopharynx Carcinoma or affiliated genes

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Publications for Nasopharynx Carcinoma

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Sources:
52PubMed
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Articles related to Nasopharynx Carcinoma:

(show all 15)
idTitleAuthorsYear
1
Diagnosis of pediatric nasopharynx carcinoma after recurrent adenoidectomy. (24392236)
2013
2
Nasopharynx carcinoma: a rare primary for bilateral breast metastasis. (22778459)
2012
3
Anesthetic considerations in a child with a diagnosis of nasopharynx carcinoma who was on radiotherapy after induction chemotherapy with mucositis toxicities. (18673311)
2008
4
Pneumocephalus in nasopharynx carcinoma. (18195505)
2008
5
Nasopharynx carcinoma complicated with pneumocephalus. (16292487)
2006
6
A microcystic adnexal carcinoma in the auditory canal 15 years after radiotherapy of a 12-year-old boy with nasopharynx carcinoma. (15925985)
2005
7
QSAR of antineoplastics IV: Hansch analysis of N-(7-indolyl)benzenesulfonamides against KB human nasopharynx carcinoma, colon 38 murine adenocarcinoma and P388 murine leukemia cell lines. (11469750)
2001
8
The use of pilocarpine hydrochloride to prevent xerostomia in a child treated with high dose radiotherapy for nasopharynx carcinoma. (9861344)
1998
9
Syndrome of inappropriate secretion of antidiuretic hormone in nasopharynx carcinoma. (9260257)
1997
10
Factors influencing adjustment of patients suffering from nasopharynx carcinoma--implications for oncology social work. (9385710)
1997
11
Nasopharynx carcinoma: choice of treatment. (7558969)
1995
12
The detection of nasopharynx carcinoma in technetium-99m (V) dimercaptosuccinic acid SPECT imaging. (8386992)
1993
13
Primary hyperparathyroidism with triple cancers consisting of renal cell carcinoma, nasopharynx carcinoma and thyroid carcinoma. (839605)
1977
14
Intramedullary cervical cord metastasis from a nasopharynx carcinoma. (4852541)
1974
15
Sensitivity to irradiation of the brain stem. Irradiation myelitis in the treatment of a nasopharynx carcinoma. (4207294)
1974

Variations for Nasopharynx Carcinoma

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Sources:
1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Nasopharynx Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.839G> C (p.Arg280Thr)single nucleotide variantPathogenicrs121912660GRCh37Chr 17, 7577099: 7577099

Expression for genes affiliated with Nasopharynx Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nasopharynx Carcinoma

Search GEO for disease gene expression data for Nasopharynx Carcinoma.

Pathways for genes affiliated with Nasopharynx Carcinoma

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Sources:
50PathCards, 30KEGG, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 54R&D Systems
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Pathways related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CDH1, TP53
29.9TP53, CDKN2A
39.9TP53, CDKN2A
4
Show member pathways
9.9TP53, CDKN2A
5
Show member pathways
Cell cycle38
9.6CDH1, CDKN2A, TP53
69.5CDKN2A, TP53, HLA-A
79.5CDKN2A, TP53, HLA-A
89.3TP53, RASSF1, CDKN2A, CDH1
9
Show member pathways
Signaling Pathways in Glioblastoma38
9.3CDH1, CDKN2A, RASSF1, TP53
10
Show member pathways
Wnt Signaling Pathway NetPath38
9.1CDH1, BRD7, TP53

Compounds for genes affiliated with Nasopharynx Carcinoma

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Sources:
45Novoseek, 3BitterDB, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1acnu4510.3CDKN2A, TP53
2hpvs4510.2CDKN2A, TP53
3aristolochic acid45 311.2CDH1, TP53
4olomoucine45 1111.2CDKN2A, TP53
5temozolomide45 1111.1TP53, CDKN2A
6hmba4510.1CDKN2A, TP53
7aflatoxin b145 2411.1CDKN2A, TP53
8isoniazid45 51 1112.1CDKN2A, CD79A
9nocodazole45 1111.0TP53, CD79A, CDH1
10bcnu4510.0TP53, CDKN2A
11depsipeptide4510.0TP53, CDKN2A, CDH1
12irinotecan45 51 1112.0TP53, CDKN2A, CDH1
13thymidylate459.9CDH1, CDKN2A, TP53
14indole-3-carbinol459.9CDH1, TP53
15sodium bisulfite459.9CDH1, CDKN2A, RASSF1
16adriamycin459.9TP53, CDKN2A, CDH1
17docetaxel45 51 61 1112.9TP53, CDKN2A, CDH1
18egcg459.9TP53, CDKN2A, CDH1
19p00001459.9CDH1, CDKN2A
20cytosine45 2410.9CDH1, CDKN2A, RASSF1
21mg 13245 6110.9CDH1, CDKN2A, TP53
22nickel45 2410.7CDH1, CDKN2A
235-methylcytosine45 2410.7TP53, RASSF1, CDKN2A, CDH1
24o6-methylguanine459.7CDH1, CDKN2A, RASSF1, TP53
25crcs459.7TP53, RASSF1, CDKN2A, CDH1
26n acetylcysteine459.7CDH1, CD79A, CDKN2A, TP53
27methotrexate51 45 1111.7CDKN2A, CD79A, CDH1
28paraffin459.7TP53, CDKN2A, CD79A, CDH1
29azathioprine45 3 51 1112.6RASSF1, CDKN2A, CD79A, CDH1
30folate459.6CDH1, CD79A, CDKN2A, RASSF1
31agar459.6RASSF1, CDKN2A, CD79A, CDH1
325fluorouracil459.6CDH1, CDKN2A, TP53, HLA-A
33cisplatin45 51 61 1112.6TP53, RASSF1, CDKN2A, CDH1
34zonisamide45 51 1111.5CD79A, HLA-A
35estrogen459.3CDH1, CD79A, CDKN2A, RASSF1, TP53
36retinoic acid45 2410.3CDH1, CD79A, CDKN2A, RASSF1, TP53
37arginine459.3CDH1, CD79A, CDKN2A, TP53, HLA-A
38oligonucleotide459.2HLA-A, TP53, RASSF1, CDKN2A
39alanine459.2HLA-A, RASSF1, CDKN2A, CD79A, CDH1
405-aza-2deoxycytidine459.1CDH1, CDKN2A, RASSF1, ZMYND10, TP53, HLA-A

GO Terms for genes affiliated with Nasopharynx Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.6CDKN2A, TP53
2nucleusGO:0056347.1TP53, TMEM8B, BRD7, CCDC19, PDLIM7, RASSF1

Biological processes related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.9CDKN2A, TP53
2Ras protein signal transductionGO:0072659.7CDKN2A, RASSF1, TP53
3positive regulation of cell cycle arrestGO:0711589.6CDKN2A, TP53
4cell cycle arrestGO:0070509.5TP53, RASSF1, CDKN2A
5positive regulation of transcription, DNA-templatedGO:0458938.8CDH1, CDKN2A, BRD7, TP53

Molecular functions related to Nasopharynx Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.8CDKN2A, TP53
2p53 bindingGO:0020399.1CDKN2A, BRD7, TP53
3transcription factor bindingGO:0081349.1CDKN2A, BRD7, TP53
4protein bindingGO:0055156.3BRD7, TMEM8B, TP53, HLA-A, ZMYND10, COLQ

Products for genes affiliated with Nasopharynx Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nasopharynx Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet