Nasopharynx Carcinoma malady

Disease Ontology: A respiratory system cancer that is located in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.⁶

MalaCards: Nasopharynx Carcinoma, also known as nasopharyngeal carcinoma, is related to nasopharyngitis and salivary gland cancer. An important gene associated with Nasopharynx Carcinoma is NPIP (nuclear pore complex interacting protein), and among its related pathways are Non-small cell lung cancer and Transcription Ligand-dependent activation of the ESR1/SP pathway. The compounds sodium bisulfite and ursolic acid have been mentioned in the context of this disorder. Affiliated tissues include the nasopharynx and skin, and related mouse phenotypes are immune system and tumorigenesis.

Wikipedia: Nasopharyngeal carcinoma (NPC) is the most common cancer originating in the nasopharynx, the uppermost...⁴⁴ more...

OMIM: 607107

Aliases & Descriptions:

nasopharynx carcinoma 6 8 nasopharyngeal carcinoma 6 7 30 33 32 malignant neoplasm of nasopharynx 6 43 malignant neoplasm of other specified site of nasopharynx (disorder) 6 malignant neoplasm of posterior wall of nasopharynx nos (disorder) 6 malignant neoplasm of anterior wall of nasopharynx nos (disorder) 6 malignant neoplasm of lateral wall of nasopharynx nos (disorder) 6 malignant tumor of posterior wall of nasopharynx (disorder) 6 malignant neoplasm of other specified sites of nasopharynx 6 malignant tumor of anterior wall of nasopharynx (disorder) 6 primary malignant neoplasm of anterior wall of nasopharynx 6 malignant tumor of lateral wall of nasopharynx (disorder) 6 malignant neoplasm of nasopharyngeal wall (disorder) 6 malignant neoplasm of posterior wall of nasopharynx 6 malignant neoplasm of superior wall of nasopharynx 6 malignant neoplasm of anterior wall of nasopharynx 6

malignant tumor of roof of nasopharynx (disorder) 6 malignant neoplasm of lateral wall of nasopharynx 6 malignant neoplasm of nasopharynx nos (disorder) 6 malignant tumor of posterior wall of nasopharynx 6 malignant tumor of anterior wall of nasopharynx 6 malignant tumor of lateral wall of nasopharynx 6 malignant neoplasm of nasopharyngeal wall nos 6 malignant neoplasm of nasopharynx (disorder) 6 malignant tumor of nasopharynx (disorder) 6 malignant neoplasm of roof of nasopharynx 6 malignant nasopharyngeal tumor 6 primary malignant neoplasm 43 carcinoma of nasopharynx 43 nasopharyngeal cancer 30 malignant neoplasms 43 nasopharynx cancer 6

Diseases related to nasopharynx carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 645)

id	Related Disease	Score	Top Affiliating Genes
1	nasopharyngitis	32.9	VWA5A, BRD7, VEGFA, RASSF1, ZMYND10, CD79A
2	salivary gland cancer	31.6	MMP9, CASP3, EGFR
3	tongue cancer	31.5	VEGFA, CDKN2A, CDH1, MMP9, TP53
4	carcinoma	31.0	VWA5A, BRD7, VEGFA, RASSF1, ZMYND10, CD79A
5	oral cavity cancer	30.6	VEGFA, TP53, EGFR
6	vulva cancer	30.1	TP53, EGFR
7	pancreatic cancer	29.8	VEGFA, CCND1, CASP3, EGFR
8	liver cancer	29.0	VEGFA, RASSF1, CDKN2A, CDH1, CCND1, CASP3
9	lymphoepithelioma-like carcinoma	28.8	CDH1, TP53, EGFR
10	brain cancer	28.3	VEGFA, CASP3, TP53, DMBT1, EGFR
11	pancreatic ductal carcinoma	28.1	RASSF1, CDH1, CCND1, TP53, EGFR
12	breast cancer	28.0	VEGFA, MMP9, CCND1, TP53
13	squamous cell carcinoma	28.0	CDH1, CCND1, EGFR
14	kidney cancer	27.6	VEGFA, RASSF1, TP53, EGFR, C5orf4
15	skin cancer	27.2	CDKN2A, CDH1, MMP9, CCND1, CASP3, TP53
16	vitiligo	26.9	CD79A, CASP3, HLA-A, TP53, PSMB9
17	thyroid cancer, anaplastic	26.6	CDH1, CASP3, TP53
18	urinary bladder cancer	26.2	RASSF1, CDKN2A, CDH1, TP53
19	familial colorectal cancer	26.1	CDKN2A, CDH1, CCND1, TP53
20	stomach carcinoma	26.1	VEGFA, CDH1, MMP9, CCND1, CASP3, TP53
21	retinoblastoma	26.1	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
22	oropharyngeal cancer, adult	26.0	CDKN2A, CD6, TP53, EGFR
23	angiosarcoma	25.9	VEGFA, CDKN2A, CCND1, TP53
24	testicular cancer	25.5	CDH1, MMP9, CASP3, TP53
25	verrucous carcinoma	25.3	CDKN2A, CDH1, CCND1, TP53, EGFR
26	glioblastoma	25.1	VEGFA, CDKN2A, TP53, DMBT1, EGFR
27	herpes simplex	25.0	VEGFA, CD79A, CDKN2A, CCND1, CASP3, TP53
28	thyroid cancer	25.0	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
29	thyroid cancer, follicular	24.8	VEGFA, CDH1, MMP9, CCND1, CASP3, TP53
30	lymphoblastic leukemia	24.7	VEGFA, CD79A, CDKN2A, MMP9, CCND1, CASP3
31	esophagitis	24.4	VEGFA, RASSF1, CD79A, CDKN2A, CDH1, MMP9
32	ovarian cancer	23.7	VEGFA, RASSF1, CD79A, CDKN2A, CDH1, MMP9
33	squamous cell carcinoma of the head and neck	23.7	VEGFA, CDKN2A, CDH1, MMP9, CCND1, CASP3
34	cervicitis	23.5	VEGFA, RASSF1, ZMYND10, CD79A, CDKN2A, CDH1
35	laryngeal carcinoma	23.5	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
36	acute lymphoblastic leukemia	23.4	VEGFA, CD79A, CDKN2A, MMP9, CCND1, CASP3
37	malignant mesothelioma	23.3	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CASP3
38	ductal carcinoma in situ	23.3	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
39	osteosarcoma	23.3	VEGFA, RASSF1, CDKN2A, MMP9, CCND1, CASP3
40	prostate cancer, progression of	23.3	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
41	gastrointestinal stromal tumor	23.3	VEGFA, CDKN2A, CDH1, MMP9, CCND1, CASP3
42	esophageal cancer	23.1	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
43	gallbladder carcinoma	23.0	VEGFA, ZMYND10, CDKN2A, CDH1, MMP9, CCND1
44	cervical carcinoma	23.0	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
45	hodgkin's lymphoma	22.9	VEGFA, RASSF1, CD79A, CDKN2A, MMP9, CCND1
46	thyroid carcinoma	22.8	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
47	leukemia	22.4	BRD7, VEGFA, RASSF1, CD79A, CDKN2A, CD6
48	prostate carcinoma	22.4	VEGFA, RASSF1, CDKN2A, CD6, CDH1, MMP9
49	thyroiditis	22.3	VEGFA, RASSF1, CD79A, CDKN2A, CDH1, MMP9
50	non-hodgkin lymphoma	22.2	VEGFA, CD79A, CDKN2A, MMP9, CCND1, CASP3

Clinical features from OMIM: 607107

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nasopharynx carcinoma:

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FMA organs/tissues related to nasopharynx carcinoma:

¹¹

MGI Mouse Phenotypes related to nasopharynx carcinoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	7.9	CD79A, CCND1, TP53, DMBT1, EGFR
2	tumorigenesis	MP:0002006	6.6	RASSF1, PSMB9, EGFR, DMBT1, TP53, CCND1
3	digestive/alimentary phenotype	MP:0005381	6.0	EGFR, DMBT1, TP53, CASP3, CCND1, MMP9

Genes related to nasopharynx carcinoma according to GeneCards:

(show all 30)

id	Symbol	Description	Score	GeneCards Section Context
1	NPIP	nuclear pore complex interacting protein	11.0
2	CETN1	centrin, EF-hand protein, 1	11.0	Disorders
3	ASPG	asparaginase homolog (S. cerevisiae)	11.0
4	ZMYND10	zinc finger, MYND-type containing 10	11.0
5	CCDC19	coiled-coil domain containing 19	11.0
6	C5orf4	chromosome 5 open reading frame 4	11.0
7	OSCP1	organic solute carrier partner 1	11.0
8	VWA5A	von Willebrand factor A domain containing 5A	11.0
9	TMEM8B	transmembrane protein 8B	11.0
10	GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)	11.0	Disorders
11	GOLIM4	golgi integral membrane protein 4	11.0
12	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	11.0
13	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	11.0
14	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	11.0
15	RPL31	ribosomal protein L31	11.0
16	CD6	CD6 molecule	11.0
17	BRD7	bromodomain containing 7	11.0
18	PDLIM7	PDZ and LIM domain 7 (enigma)	11.0
19	DMBT1	deleted in malignant brain tumors 1	11.0
20	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0
21	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0
22	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0
23	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0
24	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0
25	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0
26	HLA-A	major histocompatibility complex, class I, A	11.0
27	CCND1	cyclin D1	11.0
28	EGFR	epidermal growth factor receptor	11.0
29	TP53	tumor protein p53	11.0
30	VEGFA	vascular endothelial growth factor A	11.0

Pathways related to nasopharynx carcinoma according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	Non-small cell lung cancer20	10.1	RASSF1, CDKN2A
2	Transcription Ligand-dependent activation of the ESR1/SP pathway10	9.3	EGFR, VEGFA
3	Glioblastoma Multiforme36	9.1	EGFR, TP53
4	Thyroid cancer20	8.9	CDH1, CCND1, TP53
5	G1-S Phase Transition36	8.7	CDKN2A, CCND1, TP53
6	Transcription_Ligand-dependent activation of the ESR1/SP pathway41	8.5	CCND1, VEGFA, EGFR
7	p53 signaling pathway20	8.5	CDKN2A, CCND1, CASP3, TP53
8	Endometrial cancer20	8.4	CDH1, CCND1, TP53, EGFR
9	Glioma20	8.3	EGFR, TP53, CCND1, CDKN2A
10	Melanoma20	8.0	EGFR, TP53, CCND1, CDH1, CDKN2A
11	Pancreatic cancer20	7.9	EGFR, TP53, CCND1, CDKN2A, VEGFA
12	Pancreatic Adenocarcinoma36	7.8	EGFR, TP53, CCND1, MMP9, CDKN2A
13	Colorectal Cancer Metastasis36	7.7	EGFR, TP53, CASP3, CCND1, MMP9, CDH1
14	Bladder cancer20	7.0	VEGFA, EGFR, TP53, CCND1, MMP9, CDH1
15	Pathways in cancer20	6.9	EGFR, TP53, CASP3, CCND1, MMP9, CDH1

Compounds related to nasopharynx carcinoma according to GeneDecks:

(show top 50)    (show all 75)

id	Compound	Score	Top Affiliating Genes
1	sodium bisulfite32	9.6	CDH1, CDKN2A, RASSF1
2	ursolic acid32	9.5	MMP9, CCND1, CASP3
3	estrogen32	9.4	EGFR, CDH1, RASSF1
4	exisulind32	9.4	CDH1, CCND1, CASP3
5	vegf32	9.4	TP53, MMP9, CDH1
6	minocycline32 9 9	11.2	VEGFA, MMP9, CASP3
7	pd 16931632	9.2	CASP3, CCND1, VEGFA
8	azathioprine32 34 9 9	12.2	RASSF1, CD79A, CDKN2A, CDH1
9	everolimus32 9 9	11.1	EGFR, CCND1, VEGFA
10	5-methylcytosine32 18	10.1	TP53, CDH1, CDKN2A, RASSF1
11	o6-methylguanine32	9.0	TP53, CDH1, CDKN2A, RASSF1
12	olomoucine32 42 9 9	11.8	TP53, CCND1, CDKN2A
13	silymarin32	8.8	VEGFA, MMP9, CCND1, EGFR
14	sb 20358032 42	9.8	CASP3, CCND1, MMP9, CDH1, VEGFA
15	erlotinib32 34 9 9	11.8	EGFR, CCND1, CDH1, VEGFA
16	ly29400232	8.7	CASP3, CCND1, MMP9, CDH1, VEGFA
17	folate32	8.7	CCND1, MMP9, CDH1, CDKN2A, CD79A, RASSF1
18	indole-3-carbinol32	8.7	TP53, CASP3, CCND1, CDH1
19	crcs32	8.6	TP53, CCND1, CDH1, CDKN2A, RASSF1
20	gefitinib32 34 9 9	11.6	EGFR, CCND1, MMP9, CDH1, VEGFA
21	temozolomide32 9 9	10.5	EGFR, TP53, CDKN2A, VEGFA
22	5-aza-2deoxycytidine32	8.4	TP53, HLA-A, CDH1, CDKN2A, ZMYND10, RASSF1
23	depsipeptide32	8.4	TP53, CASP3, CCND1, CDH1, CDKN2A
24	sulindac sulfide32	8.4	CCND1, CASP3, TP53
25	progestin32	8.4	EGFR, CCND1, CDH1, VEGFA
26	agar32	8.4	EGFR, CCND1, CDH1, CDKN2A, CD79A, RASSF1
27	adriamycin32	8.3	TP53, CASP3, CCND1, CDH1, CDKN2A
28	resveratrol32 9 18 9	11.2	TP53, CASP3, CCND1, MMP9, VEGFA
29	celecoxib32 42 34 9 18 9	13.2	EGFR, CASP3, CCND1, MMP9, CDH1, VEGFA
30	irinotecan32 34 9 9	11.2	VEGFA, CDKN2A, CDH1, TP53, EGFR
31	suberoylanilide hydroxamic acid32	8.2	EGFR, TP53, CASP3, CCND1, CDH1
32	geldanamycin32 9 9	10.0	EGFR, TP53, CCND1, CDH1, VEGFA
33	bortezomib32 9 9	10.0	EGFR, TP53, CASP3, CCND1, VEGFA
34	butyrate32	8.0	TP53, CASP3, CCND1, MMP9, CDH1, CDKN2A
35	gemcitabine32 34 9 9	10.9	EGFR, TP53, CASP3, CCND1, VEGFA
36	arsenite32 18	8.9	TP53, CASP3, CCND1, MMP9, CDKN2A, VEGFA
37	docetaxel32 34 9 9	10.8	EGFR, TP53, CASP3, CDH1, CDKN2A, VEGFA
38	genistein32 9 18 9	10.7	EGFR, CASP3, CCND1, MMP9, CDH1, CDKN2A
39	thymidylate32	7.7	EGFR, TP53, CCND1, CDH1, CDKN2A, VEGFA
40	flavopiridol32 9 9	9.7	EGFR, TP53, CASP3, CCND1, CDKN2A, VEGFA
41	curcumin32	7.4	EGFR, TP53, CASP3, CCND1, MMP9, CDH1
42	5fluorouracil32	7.3	EGFR, TP53, HLA-A, CASP3, CDH1, CDKN2A
43	mg 13232 42	8.3	EGFR, TP53, CASP3, CCND1, CDH1, CDKN2A
44	paclitaxel32 34 9 9	10.3	EGFR, TP53, CASP3, CCND1, CDH1, CDKN2A
45	doxorubicin32 34 9 9	10.2	EGFR, TP53, CASP3, CCND1, CDH1, CDKN2A
46	paraffin32	7.1	EGFR, TP53, CCND1, MMP9, CDH1, CDKN2A
47	cycloheximide32	7.0	VEGFA, CDKN2A, MMP9, CCND1, CASP3, TP53
48	cisplatin32 34 9 9	10.0	EGFR, TP53, CASP3, CCND1, CDH1, CDKN2A
49	n acetylcysteine32	6.7	VEGFA, EGFR, TP53, CASP3, CCND1, MMP9
50	retinoic acid32 42 18	8.7	EGFR, TP53, CASP3, CCND1, MMP9, CDH1

Biological processes related to nasopharynx carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	response to UV-A	GO:070141	9.2	CCND1, EGFR
2	mitotic cell cycle G1/S transition DNA damage checkpoint	GO:031571	9.1	CCND1, TP53
3	response to DNA damage stimulus	GO:006974	8.1	RASSF1, CCND1, CASP3, TP53

Molecular functions related to nasopharynx carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	4.2	BRD7, EGFR, PDLIM7, COLQ, DMBT1, TMEM8B