ANKL
MCID: NTR003
MIFTS: 57

Natural Killer Cell Leukemia (ANKL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Natural Killer Cell Leukemia

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34MalaCards
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MalaCards: Natural Killer Cell Leukemia, also known as aggressive nk-cell leukemia, is related to leukemia and peripheral vascular disease. An important gene associated with Natural Killer Cell Leukemia is B3GAT1 (beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)), and among its related pathways are Busulfan Pathway, Pharmacodynamics and IL2 signaling events mediated by PI3K. The compounds topotecan and okt3 have been mentioned in the context of this disorder. Affiliated tissues include nk cells, bone and myeloid, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Aliases & Classifications for Natural Killer Cell Leukemia

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9Disease Ontology, 44NIH Rare Diseases, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

50
aggressive nk-cell leukemia:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

natural killer cell leukemia 9
aggressive nk-cell leukemia 9 50 63
leukemia, natural killer cell large granular lymphocytic 63
chronic lymphoproliferative disorder of nk-cells 63
large granular lymphocyte leukemia, nk-cell type 9
nk-cell large granular lymphocyte leukemia 50
aggressive natural killer cell leukemia 44
aggressive non-hodgkin lymphoma 63
aggressive nk-cell lymphoma 50
aggressive nk cell leukemia 44
nk-cell lgl leukemia 50
ankcl 50
ankl 44


External Ids:

Disease Ontology9 DOID:1035
NCIt41 C8647
ICD10 via Orphanet27 C91.7
SNOMED-CT59 128833001
SNOMED-CT via Orphanet60 128833001
UMLS via Orphanet64 C1292777

Related Diseases for Natural Killer Cell Leukemia

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18GeneCards, 19GeneDecks
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Diseases related to Natural Killer Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 339)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.2B3GAT1, BCL2L1, BCL2, IL7, IFNG, EPO
2peripheral vascular disease30.4MPO, CD79A
3vascular disease30.4TP53, BCL2L1, BCL2
4hodgkin's lymphoma30.4IL7, BCL2L1, BCL2
5tuberculosis30.1IL7, IFNG, CD79A
6rheumatoid arthritis30.0MPO, IFNG, IL7, B3GAT1, CD79A
7systemic lupus erythematosus29.7MPO, IFNG, CD79A
8multiple sclerosis29.7BCL2L1, IL7, IFNG
9melanoma29.5TP53, IL7, BCL2, BCL2L1, IFNG
10arthropathy10.7
11spasticity10.6
12synovitis10.6
13pigmented villonodular synovitis10.6
14villonodular synovitis10.6
15cerebritis10.5
16cerebral palsy10.5
17hemiplegia10.5
18arthritis10.4
19composite lymphoma10.4
20neuropathy10.4
21peripheral neuropathy10.4
22large granular lymphocyte leukemia10.4
23synovial chondromatosis10.4
24spastic cerebral palsy10.4
25charcot-marie-tooth disease10.4
26tooth disease10.4
27spastic diplegia10.3
28clubfoot10.3
29hemarthrosis10.3
30atherosclerosis10.3
31foot drop10.3
32osteoarthritis10.3
33artery disease10.3
34ischemia10.3
35malignant histiocytosis10.2
36hemophagocytic lymphohistiocytosis10.2
37common variable immunodeficiency10.2
38hepatitis10.2
39histiocytosis10.2
40meningitis10.2
41nephrotic syndrome10.2
42acute promyelocytic leukemia10.2
43hematopoietic stem cell transplantation10.2
44limb ischemia10.2
45tarsal tunnel syndrome10.2
46arteriosclerosis10.2
47compartment syndrome10.2
48critical limb ischemia10.2
49osteochondritis dissecans10.2
50diabetes mellitus10.2

Graphical network of the top 20 diseases related to Natural Killer Cell Leukemia:



Diseases related to natural killer cell leukemia

Symptoms for Natural Killer Cell Leukemia

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Drugs & Therapeutics for Natural Killer Cell Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Natural Killer Cell Leukemia

Drug clinical trials:

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Search NIH Clinical Center for Natural Killer Cell Leukemia

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Genetic Tests for Natural Killer Cell Leukemia

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Anatomical Context for Natural Killer Cell Leukemia

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34MalaCards
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MalaCards organs/tissues related to Natural Killer Cell Leukemia:

34
Nk cells, Bone, Myeloid, T cells, Bone marrow

Animal Models for Natural Killer Cell Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Natural Killer Cell Leukemia:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.3CD79A, IL7, IFNG, TP53
2MP:00020068.1BCL2L1, BCL2, IFNG, TP53
3MP:00053678.0CD79A, BCL2, IFNG, TP53
4MP:00107717.7TP53, EPO, IFNG, BCL2, BCL2L1
5MP:00053857.6MPO, TP53, EPO, IFNG, BCL2
6MP:00036317.4TP53, IFNG, BCL2, BCL2L1, B3GAT1, CD79A
7MP:00053847.3TP53, EPO, IFNG, BCL2, BCL2L1, CD79A
8MP:00053877.1MPO, TP53, IFNG, IL7, BCL2, BCL2L1
9MP:00053766.9MPO, TP53, EPO, IFNG, BCL2, BCL2L1
10MP:00107686.8MPO, TP53, EPO, IFNG, BCL2, BCL2L1
11MP:00053976.6CD79A, MPO, TP53, EPO, IFNG, IL7

Publications for Natural Killer Cell Leukemia

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53PubMed
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Articles related to Natural Killer Cell Leukemia:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Adult aggressive natural killer cell leukemia. (23241562)
2013
2
Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature. (23510456)
2013
3
Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. (23181473)
2013
4
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. (24427365)
2013
5
Anti-cancer activity of gemcitabine against natural killer cell leukemia/lymphoma. (23772641)
2013
6
Successful disease control with L-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure. (22891745)
2013
7
Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation. (22360679)
2012
8
Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication. (23037625)
2012
9
Collapsing glomerulopathy associated with natural killer cell leukemia: a case report and review of the literature. (21908087)
2011
10
Sustained CR of refractory aggressive natural killer cell leukemia following unrelated cord blood transplantation. (20676148)
2010
11
Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (20046078)
2009
12
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: a case report of composite lymphoma. (19269751)
2009
13
A case of natural killer cell leukemia misdiagnosed as tuberculous lymphadenopathy. (19571615)
2009
14
Aggressive natural killer cell leukemia: is Epstein-Barr virus negativity an indicator of a favorable prognosis? (19153474)
2008
15
Aggressive natural killer cell leukemia presenting with hemophagocytic lymphohistiocytosis. (17853464)
2008
16
Precursor natural killer cell leukemia. (17417789)
2008
17
Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature. (17261497)
2007
18
Aggressive natural killer cell leukemia in a patient with common variable immunodeficiency syndrome. (16785152)
2006
19
Retroviral expression screening of oncogenes in natural killer cell leukemia. (15978945)
2005
20
Aggressive Natural Killer-Cell Leukemia: report of five cases and review of the literature. (15621755)
2004
21
Aggressive natural killer cell leukemia/lymphoma: case report, use of telesynergy and review of the literature. (15360011)
2004
22
Marked elevation of soluble fas ligand and cytokine secretion after splenectomy in aggressive natural killer cell leukemia/lymphoma. (15512819)
2004
23
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. (14961041)
2004
24
Unusual lymphoma manifestations: case 1. Natural killer cell leukemia with dermal erythema and vascular epidermal growth factor production. (14752078)
2004
25
Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. (12543867)
2003
26
Large granular lymphocyte leukemia and natural killer cell leukemia/lymphomas. (12943609)
2003
27
Aggressive natural killer cell leukemia: clinical features and treatment outcome. (12495907)
2002
28
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma. (11891818)
2002
29
Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. (11568749)
2001
30
Blastic natural killer cell leukemia/lymphoma presenting as overt leukemia. (11779295)
2001
31
Long-term remission induced by corticosteroids, cyclophosphamide, and methotrexate in a patient with natural killer cell leukemia. (10696134)
2000
32
Aggressive natural killer cell leukemia/lymphoma: a comprehensive cytogenetic study by spectral karyotyping. (11043424)
2000
33
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma. (10803505)
2000
34
Epstein-Barr virus-infected natural killer cell leukemia. (11426629)
2000
35
Blastoid natural killer cell leukemia. (10439811)
1999
36
Interferon-gamma prevents apoptosis in Epstein-Barr virus-infected natural killer cell leukemia in an autocrine fashion. (10233902)
1999
37
Natural killer cell leukemia as a cause of peripheral neuropathy and meningitis: case report. (9710063)
1998
38
Aggressive natural killer cell leukemia: report of a case in a Caucasian boy. (9549932)
1998
39
Aggressive natural killer cell leukemia/lymphoma. (9643496)
1998
40
Blastic natural killer cell leukemia/lymphoma: a clinicopathologic study. (9331296)
1997
41
Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. (8599969)
1996
42
Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. (7736391)
1995
43
Recognition of unusual presentation of natural killer cell leukemia. (7572992)
1995
44
Natural killer cell leukemia. An autopsy case. (7979914)
1994
45
Natural killer cell leukemia presenting with a peripheral neuropathy. (8414048)
1993
46
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. (1447189)
1992
47
Cytokine levels in aggressive natural killer cell leukemia and malignant histiocytosis. (1911378)
1991
48
Hemophagocytic syndrome associated with aggressive natural killer cell leukemia. (1746541)
1991
49
Hematopoiesis in patients with acute natural killer cell leukemia and large granular lymphocytosis: relationship between clinical features and hematopoietic inhibitor activity of peripheral mononuclear cells. (2806481)
1989
50
Aggressive natural killer cell leukemia/lymphoma with N901-positive surface phenotype: evidence for the existence of a third lineage in lymphoid cells. (2461636)
1988

Variations for Natural Killer Cell Leukemia

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Expression for genes affiliated with Natural Killer Cell Leukemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Natural Killer Cell Leukemia

Search GEO for disease gene expression data for Natural Killer Cell Leukemia.

Pathways for genes affiliated with Natural Killer Cell Leukemia

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 5Cell Signaling Technology, 13EMD Millipore, 31KEGG, 58SinoBiological, 62Tocris Bioscience
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Pathways related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Catalytic cycle of mammalian FMOs39
9.4BCL2, BCL2L1
2
Show member pathways
IL2 signaling events mediated by STAT539
9.4BCL2L1, BCL2
3
Show member pathways
9.4BCL2L1, BCL2
49.4BCL2L1, BCL2
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.4BCL2L1, BCL2
69.3BCL2, IFNG
7
Show member pathways
9.3IFNG, BCL2
8
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.3BCL2L1, IFNG
99.2EPO, TP53
109.1BCL2, TP53
11
Show member pathways
9.1TP53, BCL2
129.1TP53, BCL2
13
Show member pathways
9.1BCL2L1, BCL2, IL7
14
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.0EPO, BCL2, BCL2L1
158.9EPO, IFNG, BCL2
168.8IFNG, BCL2, BCL2L1
17
Show member pathways
8.8IFNG, BCL2, BCL2L1
188.7BCL2L1, TP53, MPO
19
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.6BCL2L1, BCL2, TP53
208.6BCL2L1, BCL2, TP53
21
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.6BCL2L1, BCL2, TP53
22
Show member pathways
8.6TP53, BCL2, BCL2L1
23
Show member pathways
8.6TP53, BCL2, BCL2L1
24
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
8.6TP53, BCL2, BCL2L1
25
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
8.6TP53, BCL2, BCL2L1
26
Show member pathways
8.6BCL2L1, BCL2, TP53
27
Show member pathways
8.6BCL2L1, BCL2, TP53
288.6BCL2L1, BCL2, TP53
29
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
8.6TP53, BCL2, BCL2L1
30
Show member pathways
8.6BCL2L1, BCL2, TP53
31
Show member pathways
Type III interferon signaling39
8.5BCL2L1, IL7, IFNG, EPO
328.5BCL2, IFNG, TP53
338.5BCL2, IFNG, TP53
34
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5BCL2, IFNG, TP53
358.5TP53, IFNG, BCL2L1
36
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.4BCL2L1, BCL2, IFNG, MPO
37
Show member pathways
8.3TP53, IL7, BCL2, BCL2L1
38
Show member pathways
8.2CD79A, BCL2L1, BCL2, TP53
39
Show member pathways
8.1CD79A, BCL2, IFNG, TP53
40
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.0TP53, IFNG, BCL2, BCL2L1
417.8TP53, EPO, IL7, BCL2, BCL2L1
42
Show member pathways
7.7TP53, EPO, IFNG, IL7, BCL2
43
Show member pathways
7.2TP53, EPO, IFNG, IL7, BCL2, BCL2L1

Compounds for genes affiliated with Natural Killer Cell Leukemia

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1topotecan46 1210.9EPO, BCL2L1
2okt3469.5CD79A, IL7, IFNG
3at 101629.4BCL2L1, BCL2
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.4BCL2L1, BCL2, IL7
5methylcellulose469.3EPO, IFNG, IL7
6gm-csf46 3010.2BCL2L1, EPO, IFNG
7staurosporin469.2BCL2, BCL2L1, IFNG
8mycophenolate mofetil46 52 1211.2CD79A, IFNG, EPO
910-hydroxycamptothecin469.0BCL2, TP53, BCL2L1
107-hydroxystaurosporine46 1210.0BCL2L1, BCL2, TP53
11chlorambucil46 1210.0BCL2, TP53, BCL2L1
12z-vad-fmk46 6210.0BCL2L1, BCL2, TP53
13sulindac sulfide469.0BCL2L1, TP53, BCL2
14noxa469.0TP53, BCL2, BCL2L1
15cd 437469.0TP53, BCL2, BCL2L1
16indole-3-carbinol468.9BCL2L1, BCL2, TP53
17dutp468.9TP53, BCL2L1, BCL2
18sulindac46 129.9BCL2, BCL2L1, TP53
19depsipeptide468.9TP53, BCL2L1, BCL2
20triptolide468.9BCL2, IFNG, TP53
212-methoxyestradiol46 62 2510.8BCL2, TP53, BCL2L1
22parthenolide46 39.8TP53, IFNG, BCL2L1
23histamine46 30 2510.8B3GAT1, MPO, IFNG, IL7, CD79A
24n-(4-hydroxyphenyl)retinamide468.8TP53, BCL2, BCL2L1
25cyclophosphamide46 52 1210.8TP53, MPO, BCL2, IL7
26roscovitine468.7BCL2L1, TP53, BCL2
27oxaliplatin46 52 1210.6BCL2L1, MPO, TP53
28fludarabine46 52 1210.6BCL2L1, TP53, BCL2
29phosphatidylserine46 30 1210.6BCL2, TP53, BCL2L1, CD79A
30rapamycin468.4EPO, IFNG, IL7, BCL2L1, BCL2
31suberoylanilide hydroxamic acid468.4BCL2L1, BCL2, IFNG, TP53
32pdtc468.4TP53, BCL2L1, IFNG, BCL2
33lactacystin468.4TP53, IFNG, BCL2, BCL2L1
34dexamethasone46 52 30 1211.3BCL2, IL7, IFNG, CD79A, BCL2L1
35flavopiridol46 129.3BCL2L1, BCL2, TP53
36retinoid468.3BCL2L1, IFNG, TP53, BCL2
37n acetylcysteine468.3TP53, BCL2, BCL2L1, CD79A, MPO
38paraffin468.2TP53, BCL2, CD79A, BCL2L1, MPO
39cytarabine46 52 1210.2TP53, EPO, BCL2, MPO, BCL2L1
40h2o2468.2CD79A, BCL2L1, BCL2, TP53, MPO
41cisplatin46 52 62 1211.1TP53, BCL2L1, BCL2, EPO, MPO
42melphalan46 52 1210.1EPO, IFNG, BCL2L1, CD79A, TP53
43sb 20358046 629.1TP53, IFNG, BCL2, BCL2L1
44carboplatin46 52 1210.1MPO, TP53, BCL2, IFNG, EPO
45cycloheximide468.0IL7, BCL2L1, BCL2, TP53, IFNG
465fluorouracil468.0TP53, MPO, IFNG, BCL2L1, BCL2
47estrogen468.0TP53, IL7, BCL2, BCL2L1, B3GAT1, CD79A
48butyrate467.6IFNG, EPO, TP53, MPO, BCL2, BCL2L1
49retinoic acid46 258.3IFNG, BCL2, CD79A, BCL2L1, IL7, TP53
50vegf466.9CD79A, MPO, TP53, EPO, IFNG, IL7

GO Terms for genes affiliated with Natural Killer Cell Leukemia

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17Gene Ontology
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Cellular components related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3IL7, IFNG, EPO, MPO
2mitochondrionGO:0057398.2BCL2L1, BCL2, TP53, MPO

Biological processes related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1homeostasis of number of cells within a tissueGO:0488739.9IL7, BCL2
2negative regulation of calcium ion transport into cytosolGO:0105239.9EPO, BCL2
3B cell proliferationGO:0421009.8CD79A, BCL2
4negative regulation of growth of symbiont in hostGO:0441309.8MPO, IFNG
5B cell receptor signaling pathwayGO:0508539.8CD79A, BCL2
6negative regulation of anoikisGO:20008119.8BCL2, BCL2L1
7negative regulation of autophagyGO:0105079.8BCL2, BCL2L1
8positive regulation of B cell proliferationGO:0308909.8BCL2, IL7
9regulation of mitochondrial membrane potentialGO:0518819.7BCL2L1, BCL2
10negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.7BCL2L1, BCL2
11T cell lineage commitmentGO:0023609.7TP53, IL7
12response to salt stressGO:0096519.6EPO, TP53
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5BCL2L1, BCL2
14B cell lineage commitmentGO:0023269.5BCL2, TP53
15ovarian follicle developmentGO:0015419.5BCL2, BCL2L1
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL7, BCL2, BCL2L1
17cellular response to glucose starvationGO:0421499.5TP53, BCL2
18response to ischemiaGO:0029319.5TP53, BCL2
19nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.4BCL2L1, BCL2
20cell agingGO:0075699.4TP53, BCL2
21positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.4BCL2, TP53
22humoral immune responseGO:0069599.4BCL2, IL7, IFNG
23response to gamma radiationGO:0103329.4TP53, BCL2
24response to cytokineGO:0340979.3BCL2L1, BCL2
25protein import into nucleus, translocationGO:0000609.3IFNG, TP53
26T cell differentiation in thymusGO:0330779.3TP53, BCL2
27positive regulation of cell proliferationGO:0082849.2BCL2L1, IL7, EPO
28intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1BCL2, BCL2L1
29cellular response to hypoxiaGO:0714569.0TP53, EPO, BCL2
30regulation of mitochondrial membrane permeabilityGO:0469029.0BCL2L1, BCL2, TP53
31release of cytochrome c from mitochondriaGO:0018369.0BCL2L1, BCL2, TP53
32positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.0TP53, BCL2, BCL2L1
33neuron apoptotic processGO:0514029.0BCL2L1, BCL2, TP53
34intrinsic apoptotic signaling pathwayGO:0971939.0TP53, BCL2, BCL2L1
35negative regulation of apoptotic processGO:0430668.3MPO, TP53, IL7, BCL2, BCL2L1
36apoptotic processGO:0069157.9TP53, EPO, IFNG, BCL2, BCL2L1

Molecular functions related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BH3 domain bindingGO:0514349.3BCL2L1, BCL2
2protein phosphatase 2A bindingGO:0517218.8BCL2, TP53
3protein heterodimerization activityGO:0469828.6BCL2L1, BCL2, TP53

Products for genes affiliated with Natural Killer Cell Leukemia

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Sources for Natural Killer Cell Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet