ANKL
MCID: NTR003
MIFTS: 56

Natural Killer Cell Leukemia (ANKL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Natural Killer Cell Leukemia

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32MalaCards
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MalaCards: Natural Killer Cell Leukemia, also known as aggressive nk-cell leukemia, is related to leukemia and non-hodgkin lymphoma. An important gene associated with Natural Killer Cell Leukemia is GLIS2 (GLIS family zinc finger 2), and among its related pathways are TGF-Beta Pathway and 14-3-3 Induced Apoptosis. The compounds estrogen and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include nk cells, myeloid and t cells, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Natural Killer Cell Leukemia

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8Disease Ontology, 48Orphanet, 60UMLS, 42NIH Rare Diseases, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
aggressive nk-cell leukemia:
Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

natural killer cell leukemia 8
aggressive nk-cell leukemia 8 48 60
leukemia, natural killer cell large granular lymphocytic 60
large granular lymphocyte leukemia, nk-cell type 8
chronic lymphoproliferative disorder of nk-cells 60
nk-cell large granular lymphocyte leukemia 48
aggressive natural killer cell leukemia 42
aggressive non-hodgkin lymphoma 60
aggressive nk-cell lymphoma 48
aggressive nk cell leukemia 42
nk-cell lgl leukemia 48
ankcl 48
ankl 42


External Ids:

Disease Ontology8 DOID:1035
NCIt39 C8647
ICD10 via Orphanet26 C91.7
SNOMED-CT56 128833001
SNOMED-CT via Orphanet57 128833001
UMLS via Orphanet61 C1292777

Related Diseases for Natural Killer Cell Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Natural Killer Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 382)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5CD7, B3GAT1, TP53, BCL2, IL7, IFNG
2non-hodgkin lymphoma31.3IL7, GZMB, BCL2, BCL2L1
3synovitis30.8IL7
4acute leukemia30.6MPO, BCL2L1, IL7, EPO, CD7
5arthritis30.5MPO, GZMB, IFNG
6neuropathy30.5CD79A
7chronic lymphocytic leukemia30.5IL7, BCL2L1, BCL2
8vascular disease30.4BCL2L1, TP53, BCL2
9atherosclerosis30.3IL7, MPO, GZMB
10ischemia30.3MPO
11nephrotic syndrome30.3CD79A
12meningitis30.3CD79A
13hepatitis30.3GZMB
14hemophagocytic lymphohistiocytosis30.3GZMB
15myeloid leukemia30.3MPO, BCL2, BCL2L1
16peripheral vascular disease30.3MPO, CD79A
17hodgkin's lymphoma30.3BCL2L1, BCL2, GZMB, TIA1, IL7
18diabetes mellitus30.2CD79A
19hypertension30.1CD79A
20panniculitis30.1TIA1
21tuberculosis30.0IFNG, IL7, GZMB, CD79A
22rheumatoid arthritis30.0IFNG, CD79A, B3GAT1, GZMB, CD7, MPO
23peritonitis29.6MPO
24lupus erythematosus29.6CD79A
25glomerulonephritis29.6MPO, CD79A
26lichen planus29.6GZMB
27sarcoma29.6TP53, B3GAT1
28multiple sclerosis29.6IFNG, IL7, BCL2L1
29dermatitis29.6GZMB, IFNG, CD79A
30melanoma29.6BCL2L1, TP53, BCL2, IL7, GZMB, TIA1
31arthropathy10.6
32pigmented villonodular synovitis10.5
33villonodular synovitis10.5
34cerebritis10.5
35cerebral palsy10.4
36hemiplegia10.4
37spastic cerebral palsy10.4
38liver lymphoma10.4
39composite lymphoma10.4
40peripheral neuropathy10.4
41chronic nk-cell lymphocytosis10.3
42t-cell large granular lymphocyte leukemia10.3
43charcot-marie-tooth disease10.3
44tooth disease10.3
45spastic diplegia10.3
46clubfoot10.3
47osteoarthritis10.3
48hemarthrosis10.3
49lymphoid leukemia10.2
50acute myeloid leukemia10.2

Graphical network of the top 20 diseases related to Natural Killer Cell Leukemia:



Diseases related to natural killer cell leukemia

Clinical Features for Natural Killer Cell Leukemia

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Drugs & Therapeutics for Natural Killer Cell Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Natural Killer Cell Leukemia

Drug clinical trials:

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Search NIH Clinical Center for Natural Killer Cell Leukemia

Search CenterWatch for Natural Killer Cell Leukemia

Genetic Tests for Natural Killer Cell Leukemia

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Anatomical Context for Natural Killer Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to Natural Killer Cell Leukemia:

32
Nk cells, Myeloid, T cells, Bone, Monocytes, Bone marrow, B cells, Skin

Animal Models for Natural Killer Cell Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Natural Killer Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4IFNG, GLIS2, CD79A
2MP:00020069.3BCL2L1, IFNG
3MP:00107686.1TIA1, IFNG, GZMB, MPO, GLIS2, EPO
4MP:00053846.1CD79A, GLIS2, GZMB, IFNG, CD7, EPO
5MP:00053875.9MPO, GZMB, IFNG, TIA1, GLIS2, CD79A
6MP:00053975.6TP53, TIA1, IFNG, GZMB, MPO, CD79A

Publications for Natural Killer Cell Leukemia

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50PubMed
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Articles related to Natural Killer Cell Leukemia:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Ataxia-telangiectasia mutated kinase-mediated upregulation of NKG2D ligands on leukemia cells by resveratrol results in enhanced natural killer cell susceptibility. (23445485)
2013
2
Successful disease control with L-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure. (22891745)
2013
3
The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patients. (23277329)
2013
4
Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation. (22360679)
2012
5
T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias. (21749307)
2011
6
Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia. (21370424)
2011
7
Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells. (21321117)
2011
8
NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. (20085940)
2010
9
Sustained CR of refractory aggressive natural killer cell leukemia following unrelated cord blood transplantation. (20676148)
2010
10
Differential effects of IL-2 and IL-21 on expansion of the CD4+ CD25+ Foxp3+ T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia. (20081380)
2010
11
Natural-killer cell amplification for adoptive leukemia relapse immunotherapy: comparison of three cytokines, IL-2, IL-15, or IL-7 and impact on NKG2D, KIR2DL1, and KIR2DL2 expression. (20172016)
2010
12
Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells. (20640055)
2010
13
Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (20046078)
2009
14
Myeloid/natural killer cell precursor acute leukemia with multiple subcutaneous nodules as the initial presentation: a case report and literature review. (19639272)
2009
15
Precursor natural killer cell leukemia. (17417789)
2008
16
A rare case of co-existent aggressive natural killer cell and acute monocytic leukemia with cytomegalovirus infection. (18437504)
2008
17
Cytogenetic characterization of natural killer cell leukemia. (18503833)
2008
18
Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. (17609265)
2007
19
Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature. (17261497)
2007
20
Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia. (17673900)
2007
21
CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. (16046525)
2005
22
Prolonged treatment response in aggressive natural killer cell leukemia. (16019515)
2005
23
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. (14961041)
2004
24
Identification of natural killer cell receptor phenotypes associated with leukemia. (15470487)
2004
25
Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. (12543867)
2003
26
Acute leukemia with myeloid, B-, and natural killer cell differentiation. (12562262)
2003
27
Large granular lymphocyte leukemia and natural killer cell leukemia/lymphomas. (12943609)
2003
28
Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. (12200350)
2002
29
CD56(+) TdT(+) blastic natural killer cell tumor of the skin: a primitive systemic malignancy related to myelomonocytic leukemia. (12015765)
2002
30
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma. (11891818)
2002
31
Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. (11568749)
2001
32
Blastic natural killer cell leukemia/lymphoma presenting as overt leukemia. (11779295)
2001
33
T-large granular lymphocyte leukemia accompanied by an increase of natural killer cells (CD3-) and associated with ulcerative colitis and autoimmune hepatitis. (11342376)
2001
34
Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray. (11583976)
2001
35
Myeloid natural killer cell leukemia resembling a variant of acute promyelocytic leukemia. (11454535)
2001
36
Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. (10961901)
2000
37
Altered natural killer cell differentiation in CD34+ progenitors from chronic myeloid leukemia patients. (10851076)
2000
38
Blastic natural killer cell leukemia/lymphoma: a clinicopathologic study. (9331296)
1997
39
Natural killer cell activity and cytokine production as prognostic factors in adult acute leukemia. (8642865)
1996
40
Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture. (8630414)
1996
41
Natural killer cells adhere to bone marrow fibroblasts and inhibit adhesion of acute myeloid leukemia cells. (7596192)
1995
42
Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. (7736391)
1995
43
The effect of human IL-2-activated natural killer and T cells on graft-versus-host disease and graft-versus-leukemia in SCID mice bearing human leukemic cells. (7482742)
1995
44
Recognition of unusual presentation of natural killer cell leukemia. (7572992)
1995
45
Natural killer cell leukemia. An autopsy case. (7979914)
1994
46
Natural killer cell leukemia presenting with a peripheral neuropathy. (8414048)
1993
47
Interleukin 12 augments natural killer-cell mediated cytotoxicity in hairy cell leukemia. (8104069)
1993
48
Cytokine levels in aggressive natural killer cell leukemia and malignant histiocytosis. (1911378)
1991
49
In vitro enhancement of natural killer cell activity against herpesvirus-infected targets in patients with acute lymphocytic leukemia. (1848749)
1991
50
Distinct characteristics of lymphokine-activated killer (LAK) cells derived from patients with B-cell chronic lymphocytic leukemia (B-CLL). A factor in B-CLL serum promotes natural killer cell-like LAK cell growth. (2207313)
1990

Genetic Variations for Natural Killer Cell Leukemia

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Expression for genes affiliated with Natural Killer Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Natural Killer Cell Leukemia

Search GEO for disease gene expression data for Natural Killer Cell Leukemia.

Pathways for genes affiliated with Natural Killer Cell Leukemia

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 59Tocris Bioscience, 52R&D Systems, 55SinoBiological, 12EMD Millipore
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Pathways related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL7
2
Hide members
9.7TP53, BCL2
39.7TP53, BCL2
49.4GZMB, MPO, CD79A
59.3IFNG, BCL2, TP53
69.3BCL2L1, BCL2
79.3BCL2L1, BCL2
8
Hide members
9.3BCL2L1, BCL2
9
Hide members
9.3BCL2, BCL2L1
109.1BCL2, EPO, IFNG
119.0CD7, EPO, IL7
12
Hide members
9.0BCL2, BCL2L1, IL7
138.9IFNG, BCL2L1, BCL2
14
Hide members
8.9BCL2L1, BCL2, TP53
15
Hide members
8.9BCL2L1, BCL2, TP53
16
Hide members
8.9BCL2L1, BCL2, TP53
17
Hide members
8.9TP53, BCL2, BCL2L1
188.9TP53, BCL2, BCL2L1
19
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
8.9BCL2L1, BCL2, TP53
20
Hide members
8.9TP53, BCL2, BCL2L1
218.9IFNG, BCL2L1, TP53
22
Hide members
8.9GZMB, BCL2L1, BCL2
238.9BCL2, BCL2L1, GZMB
24
Hide members
8.9BCL2, BCL2L1, GZMB
25
Development EPO-induced Jak-STAT pathway
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8.7EPO, BCL2L1, BCL2
26
Development PDGF signaling via STATs and NF-kB
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8.6BCL2, BCL2L1, MPO, IFNG
27
Hide members
8.5BCL2L1, CD79A, GZMB, IFNG
288.5TP53, BCL2L1, MPO, GZMB
298.4BCL2L1, IL7, EPO, IFNG
308.0EPO, IL7, BCL2L1, BCL2, TP53

Compounds for genes affiliated with Natural Killer Cell Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CD79A
2depsipeptide4410.2TP53
3okt3449.8IL7, IFNG, CD79A
4alpha-galactosylceramide449.8IL7, IFNG, GZMB
5cyclophosphamide44 49 1111.8IL7, BCL2, TP53
6triptolide449.7TP53, BCL2, IFNG
7cyclosporin a44 28 5911.7IFNG, GZMB, CD79A
810-hydroxycamptothecin449.3BCL2L1, BCL2, TP53
9histamine44 28 2411.3MPO, CD79A, B3GAT1, IL7, IFNG
10mim1599.3BCL2L1, BCL2
11at 101599.3BCL2L1, BCL2
12staurosporin449.3BCL2, BCL2L1, IFNG
137-hydroxystaurosporine44 1110.3BCL2L1, TP53, BCL2
14tacrolimus44 49 1111.3GZMB, CD79A, IFNG, IL7
15chlorambucil44 1110.3BCL2L1, BCL2, TP53
16sulindac sulfide449.3BCL2, TP53, BCL2L1
17noxa449.3BCL2, BCL2L1, TP53
18cd 437449.2BCL2L1, TP53, BCL2
193-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.2IL7, BCL2, BCL2L1
20mycophenolate mofetil44 49 1111.2IFNG, CD79A, EPO
21bax channel blocker599.2BCL2L1, BCL2
22indole-3-carbinol449.2BCL2, TP53, BCL2L1
23parthenolide44 210.2BCL2L1, IFNG, TP53
24sulindac44 1110.1TP53, BCL2L1, BCL2
25dutp449.1BCL2L1, TP53, BCL2
26[alcl]449.1TIA1, BCL2L1, GZMB
27ha14-1599.0BCL2L1, BCL2
28heparin44 28 11 2412.0GZMB, B3GAT1, IL7, CD79A, MPO
29gm-csf44 2810.0BCL2L1, EPO, IFNG
30suberoylanilide hydroxamic acid449.0BCL2L1, TP53, IFNG, BCL2
31prednisolone44 28 1110.9GZMB, TIA1, MPO, CD79A, IFNG
32lactacystin448.9TP53, IFNG, BCL2, BCL2L1
33z-vad-fmk44 599.9TP53, GZMB, BCL2L1, BCL2
34carboplatin44 49 1110.9MPO, TP53, BCL2, EPO, IFNG
35oxygen44 249.8BCL2L1, EPO, MPO
36topotecan44 119.7EPO, BCL2L1, TP53, BCL2
37n acetylcysteine448.7CD79A, MPO, BCL2L1, BCL2, TP53
38arsenite44 249.7TIA1, BCL2, TP53, BCL2L1
395fluorouracil448.6TP53, BCL2, BCL2L1, IFNG, MPO
40dexamethasone44 49 28 1111.6BCL2L1, BCL2, CD79A, GZMB, IL7
41imatinib44 49 1110.6BCL2L1, BCL2, GZMB, EPO
42phosphatidylserine44 28 1110.5BCL2, BCL2L1, CD79A, GZMB, TP53
43melphalan44 119.4TP53, BCL2L1, EPO, CD79A, IFNG
44ly294002448.2BCL2, BCL2L1, EPO, GZMB, TP53
45rapamycin448.0BCL2, BCL2L1, IL7, EPO, GZMB, IFNG
46cytarabine44 49 1110.0EPO, MPO, BCL2L1, GZMB, BCL2, TP53
47cisplatin44 49 59 1110.9TP53, GZMB, MPO, EPO, BCL2L1, BCL2
48paraffin447.7TP53, BCL2L1, CD79A, MPO, GZMB, TIA1
49retinoic acid44 248.6TP53, GZMB, BCL2, BCL2L1, IL7, CD79A
50vegf447.0BCL2, IFNG, GZMB, MPO, CD79A, EPO

GO Terms for genes affiliated with Natural Killer Cell Leukemia

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16Gene Ontology
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Biological processes related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1T cell lineage commitmentGO:00236010.0TP53, IL7
2B cell proliferationGO:04210010.0BCL2, CD79A
3B cell lineage commitmentGO:0023269.9BCL2, TP53
4negative regulation of growth of symbiont in hostGO:0441309.9MPO, IFNG
5humoral immune responseGO:0069599.7BCL2, IL7, IFNG
6negative regulation of calcium ion transport into cytosolGO:0105239.7BCL2, EPO
7homeostasis of number of cells within a tissueGO:0488739.6BCL2, IL7, CD7
8response to salt stressGO:0096519.6EPO, TP53
9negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.5BCL2, BCL2L1
10negative regulation of anoikisGO:20008119.3BCL2, BCL2L1
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3BCL2, BCL2L1
12regulation of mitochondrial membrane permeabilityGO:0469029.2BCL2L1, BCL2, TP53
13regulation of mitochondrial membrane potentialGO:0518819.2BCL2L1, BCL2
14release of cytochrome c from mitochondriaGO:0018369.2TP53, BCL2, BCL2L1
15positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.2BCL2L1, BCL2, TP53
16negative regulation of autophagyGO:0105079.0BCL2L1, BCL2
17intrinsic apoptotic signaling pathwayGO:0971938.8TP53, BCL2, BCL2L1, GZMB
18negative regulation of apoptotic processGO:0430668.6MPO, IL7, BCL2L1, BCL2, TP53
19apoptotic processGO:0069157.6TIA1, IFNG, GZMB, EPO, BCL2L1, BCL2

Molecular functions related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2BH3 domain bindingGO:0514349.0BCL2, BCL2L1

Products for genes affiliated with Natural Killer Cell Leukemia

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  • Antibodies
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Sources for Natural Killer Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet