ANKL
MCID: NTR003
MIFTS: 52

Natural Killer Cell Leukemia (ANKL) malady

Blood, Cancer, Immune categories

Summaries for Natural Killer Cell Leukemia

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33MalaCards
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MalaCards: Natural Killer Cell Leukemia, also known as aggressive nk-cell leukemia, is related to synovitis and acute leukemia. An important gene associated with Natural Killer Cell Leukemia is GLIS2 (GLIS family zinc finger 2), and among its related pathways are TGF-Beta Pathway and 14-3-3 Induced Apoptosis. The compounds estrogen and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and myeloid, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Natural Killer Cell Leukemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
aggressive nk-cell leukemia:
Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

natural killer cell leukemia 8
aggressive nk-cell leukemia 8 49 61
leukemia, natural killer cell large granular lymphocytic 61
chronic lymphoproliferative disorder of nk-cells 61
large granular lymphocyte leukemia, nk-cell type 8
nk-cell large granular lymphocyte leukemia 49
aggressive natural killer cell leukemia 43
aggressive non-hodgkin lymphoma 61
aggressive nk-cell lymphoma 49
aggressive nk cell leukemia 43
nk-cell lgl leukemia 49
ankcl 49
ankl 43


External Ids:

Disease Ontology8 DOID:1035
NCIt40 C8647
ICD10 via Orphanet26 C91.7
SNOMED-CT57 128833001
SNOMED-CT via Orphanet58 128833001
UMLS via Orphanet62 C1292777

Related Diseases for Natural Killer Cell Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Natural Killer Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 381)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis30.8IL7
2acute leukemia30.7MPO, CD7, EPO, IL7, BCL2L1
3arthritis30.6IFNG, GZMB, MPO
4vascular disease30.4BCL2L1, BCL2, TP53
5atherosclerosis30.4IL7, MPO, GZMB
6hemophagocytic lymphohistiocytosis30.3GZMB
7peripheral vascular disease30.3CD79A, MPO
8tuberculosis30.0IFNG, GZMB, CD79A, IL7
9lichen planus29.7GZMB
10t-cell leukemia10.7
11arthropathy10.7
12pigmented villonodular synovitis10.6
13villonodular synovitis10.5
14n syndrome10.5
15leukemia/lymphoma, t-cell10.5
16spastic cerebral palsy10.4
17colon lymphoma10.4
18liver lymphoma10.4
19composite lymphoma10.4
20large granular lymphocyte leukemia10.4
21synovial chondromatosis10.4
22chronic nk-cell lymphocytosis10.4
23spastic diplegia10.3
24tooth disease10.3
25clubfoot10.3
26spasticity10.3
27foot drop10.3
28osteoarthritis10.3
29hemarthrosis10.3
30lymphoid leukemia10.2
31acute myeloid leukemia10.2
32common variable immunodeficiency10.2
33bone lymphoma10.2
34malignant histiocytosis10.2
35acute promyelocytic leukemia10.2
36mass syndrome10.2
37hematopoietic stem cell transplantation10.2
38tarsal tunnel syndrome10.2
39arteriosclerosis10.2
40septic arthritis10.2
41osteochondritis dissecans10.2
42synostosis10.2
43hemophilic arthropathy10.2
44critical limb ischemia10.2
45hemophilia10.1
46dysplasia epiphysealis hemimelica10.1
47hypertonia10.1
48spastic hemiplegia10.1
49intermittent claudication10.1
50hemochromatosis10.1

Graphical network of the top 20 diseases related to Natural Killer Cell Leukemia:



Diseases related to natural killer cell leukemia

Clinical Features for Natural Killer Cell Leukemia

Drugs & Therapeutics for Natural Killer Cell Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Natural Killer Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Natural Killer Cell Leukemia

Search NIH Clinical Center for Natural Killer Cell Leukemia

Search CenterWatch for Natural Killer Cell Leukemia

Genetic Tests for Natural Killer Cell Leukemia

Anatomical Context for Natural Killer Cell Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Natural Killer Cell Leukemia:

33
Skin, Bone marrow, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells

Animal Models for Natural Killer Cell Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Natural Killer Cell Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4IFNG, GLIS2, CD79A
2MP:00020069.3BCL2L1, IFNG
3MP:00107686.1TIA1, IFNG, GZMB, MPO, GLIS2, EPO
4MP:00053846.1CD79A, GLIS2, GZMB, IFNG, CD7, EPO
5MP:00053875.9MPO, GZMB, IFNG, TIA1, GLIS2, CD79A
6MP:00053975.6TP53, TIA1, IFNG, GZMB, MPO, CD79A

Publications for Natural Killer Cell Leukemia

Sources:
51PubMed
See all sources

Articles related to Natural Killer Cell Leukemia:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Adult aggressive natural killer cell leukemia. (23241562)
2013
2
Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature. (23510456)
2013
3
Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition. (23690482)
2013
4
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. (24427365)
2013
5
Successful disease control with L-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure. (22891745)
2013
6
The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patients. (23277329)
2013
7
T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias. (21749307)
2011
8
Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells. (21321117)
2011
9
Natural killer-like T CD3+/CD16+CD56+ cells in chronic lymphocytic leukemia: intracellular cytokine expression and relationship with clinical outcome. (20664990)
2010
10
NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. (20085940)
2010
11
Sustained CR of refractory aggressive natural killer cell leukemia following unrelated cord blood transplantation. (20676148)
2010
12
A child with myeloid/natural killer cell precursor acute leukemia treated successfully with acute myeloid leukemia-oriented chemotherapy incorporating L-asparaginase. (20637505)
2010
13
Natural-killer cell amplification for adoptive leukemia relapse immunotherapy: comparison of three cytokines, IL-2, IL-15, or IL-7 and impact on NKG2D, KIR2DL1, and KIR2DL2 expression. (20172016)
2010
14
Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (20046078)
2009
15
2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells. (19638467)
2009
16
Myeloid/natural killer cell precursor acute leukemia with multiple subcutaneous nodules as the initial presentation: a case report and literature review. (19639272)
2009
17
Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia. (19641183)
2009
18
Aggressive natural killer cell leukemia presenting with hemophagocytic lymphohistiocytosis. (17853464)
2008
19
Cytogenetic characterization of natural killer cell leukemia. (18503833)
2008
20
Aggressive natural killer cell leukemia in a patient with common variable immunodeficiency syndrome. (16785152)
2006
21
CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. (16046525)
2005
22
Myeloid/natural killer cell precursor acute leukemia with tetraploidy. (16337859)
2005
23
Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. (15657183)
2005
24
Retroviral expression screening of oncogenes in natural killer cell leukemia. (15978945)
2005
25
Aggressive Natural Killer-Cell Leukemia: report of five cases and review of the literature. (15621755)
2004
26
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. (14961041)
2004
27
Unusual lymphoma manifestations: case 1. Natural killer cell leukemia with dermal erythema and vascular epidermal growth factor production. (14752078)
2004
28
Identification of natural killer cell receptor phenotypes associated with leukemia. (15470487)
2004
29
Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. (12543867)
2003
30
Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. (12200350)
2002
31
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma. (11891818)
2002
32
Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens. (12127564)
2002
33
Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. (11568749)
2001
34
T-large granular lymphocyte leukemia accompanied by an increase of natural killer cells (CD3-) and associated with ulcerative colitis and autoimmune hepatitis. (11342376)
2001
35
Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray. (11583976)
2001
36
Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. (10961901)
2000
37
Altered natural killer cell differentiation in CD34+ progenitors from chronic myeloid leukemia patients. (10851076)
2000
38
Acute leukemia with the phenotype of a natural killer/T cell bipotential precursor. (10037270)
1999
39
Aggressive natural killer cell leukemia: report of a case in a Caucasian boy. (9549932)
1998
40
Aggressive natural killer cell leukemia/lymphoma. (9643496)
1998
41
Blastic natural killer cell leukemia/lymphoma: a clinicopathologic study. (9331296)
1997
42
Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture. (8630414)
1996
43
Natural killer cells adhere to bone marrow fibroblasts and inhibit adhesion of acute myeloid leukemia cells. (7596192)
1995
44
Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. (7736391)
1995
45
The effect of human IL-2-activated natural killer and T cells on graft-versus-host disease and graft-versus-leukemia in SCID mice bearing human leukemic cells. (7482742)
1995
46
Natural-killer-stimulatory effect of combined low-dose interleukin-2 and interferon beta in hairy-cell leukemia patients. (7512888)
1994
47
Natural killer cell leukemia presenting with a peripheral neuropathy. (8414048)
1993
48
Interleukin 12 augments natural killer-cell mediated cytotoxicity in hairy cell leukemia. (8104069)
1993
49
Cytokine levels in aggressive natural killer cell leukemia and malignant histiocytosis. (1911378)
1991
50
Aggressive natural killer cell leukemia/lymphoma with N901-positive surface phenotype: evidence for the existence of a third lineage in lymphoid cells. (2461636)
1988

Genetic Variations for Natural Killer Cell Leukemia

Expression for genes affiliated with Natural Killer Cell Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Natural Killer Cell Leukemia

Search GEO for disease gene expression data for Natural Killer Cell Leukemia.

Pathways for genes affiliated with Natural Killer Cell Leukemia

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome, 60Tocris Bioscience, 53R&D Systems, 56SinoBiological, 12EMD Millipore
See all sources

Pathways related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL7
2
Hide members
9.7TP53, BCL2
39.7TP53, BCL2
49.4GZMB, MPO, CD79A
59.3IFNG, BCL2, TP53
69.3BCL2L1, BCL2
79.3BCL2L1, BCL2
8
Hide members
9.3BCL2L1, BCL2
9
Hide members
9.3BCL2, BCL2L1
109.1BCL2, EPO, IFNG
119.0CD7, EPO, IL7
12
Hide members
9.0BCL2, BCL2L1, IL7
138.9IFNG, BCL2L1, BCL2
14
Hide members
8.9BCL2L1, BCL2, TP53
15
Hide members
8.9BCL2L1, BCL2, TP53
16
Hide members
8.9BCL2L1, BCL2, TP53
17
Hide members
8.9TP53, BCL2, BCL2L1
188.9TP53, BCL2, BCL2L1
19
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
8.9BCL2L1, BCL2, TP53
20
Hide members
8.9TP53, BCL2, BCL2L1
218.9IFNG, BCL2L1, TP53
22
Hide members
8.9GZMB, BCL2L1, BCL2
238.9BCL2, BCL2L1, GZMB
24
Hide members
8.9BCL2, BCL2L1, GZMB
25
Development EPO-induced Jak-STAT pathway
Hide members
8.7EPO, BCL2L1, BCL2
26
Development PDGF signaling via STATs and NF-kB
Hide members
8.6BCL2, BCL2L1, MPO, IFNG
27
Hide members
8.5BCL2L1, CD79A, GZMB, IFNG
288.5TP53, BCL2L1, MPO, GZMB
298.4BCL2L1, IL7, EPO, IFNG
308.0EPO, IL7, BCL2L1, BCL2, TP53

Compounds for genes affiliated with Natural Killer Cell Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6CD79A
2depsipeptide4510.2TP53
3okt3459.8IL7, IFNG, CD79A
4alpha-galactosylceramide459.8IL7, IFNG, GZMB
5cyclophosphamide45 50 1111.8IL7, BCL2, TP53
6triptolide459.7TP53, BCL2, IFNG
7cyclosporin a45 29 6011.7IFNG, GZMB, CD79A
810-hydroxycamptothecin459.3BCL2L1, BCL2, TP53
9histamine45 29 2411.3MPO, CD79A, B3GAT1, IL7, IFNG
10mim1609.3BCL2L1, BCL2
11at 101609.3BCL2L1, BCL2
12staurosporin459.3BCL2, BCL2L1, IFNG
137-hydroxystaurosporine45 1110.3BCL2L1, TP53, BCL2
14tacrolimus45 50 1111.3GZMB, CD79A, IFNG, IL7
15chlorambucil45 1110.3BCL2L1, BCL2, TP53
16sulindac sulfide459.3BCL2, TP53, BCL2L1
17noxa459.3BCL2, BCL2L1, TP53
18cd 437459.2BCL2L1, TP53, BCL2
193-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.2IL7, BCL2, BCL2L1
20mycophenolate mofetil45 50 1111.2IFNG, CD79A, EPO
21bax channel blocker609.2BCL2L1, BCL2
22indole-3-carbinol459.2BCL2, TP53, BCL2L1
23parthenolide45 210.2BCL2L1, IFNG, TP53
24sulindac45 1110.1TP53, BCL2L1, BCL2
25dutp459.1BCL2L1, TP53, BCL2
26[alcl]459.1TIA1, BCL2L1, GZMB
27ha14-1609.0BCL2L1, BCL2
28heparin45 29 11 2412.0GZMB, B3GAT1, IL7, CD79A, MPO
29gm-csf45 2910.0BCL2L1, EPO, IFNG
30suberoylanilide hydroxamic acid459.0BCL2L1, TP53, IFNG, BCL2
31prednisolone45 29 1110.9GZMB, TIA1, MPO, CD79A, IFNG
32lactacystin458.9TP53, IFNG, BCL2, BCL2L1
33z-vad-fmk45 609.9TP53, GZMB, BCL2L1, BCL2
34carboplatin45 50 1110.9MPO, TP53, BCL2, EPO, IFNG
35oxygen45 249.8BCL2L1, EPO, MPO
36topotecan45 119.7EPO, BCL2L1, TP53, BCL2
37n acetylcysteine458.7CD79A, MPO, BCL2L1, BCL2, TP53
38arsenite45 249.7TIA1, BCL2, TP53, BCL2L1
395fluorouracil458.6TP53, BCL2, BCL2L1, IFNG, MPO
40dexamethasone45 50 29 1111.6BCL2L1, BCL2, CD79A, GZMB, IL7
41imatinib45 50 1110.6BCL2L1, BCL2, GZMB, EPO
42phosphatidylserine45 29 1110.5BCL2, BCL2L1, CD79A, GZMB, TP53
43melphalan45 119.4TP53, BCL2L1, EPO, CD79A, IFNG
44ly294002458.2BCL2, BCL2L1, EPO, GZMB, TP53
45rapamycin458.0BCL2, BCL2L1, IL7, EPO, GZMB, IFNG
46cytarabine45 50 1110.0EPO, MPO, BCL2L1, GZMB, BCL2, TP53
47cisplatin45 50 60 1110.9TP53, GZMB, MPO, EPO, BCL2L1, BCL2
48paraffin457.7TP53, BCL2L1, CD79A, MPO, GZMB, TIA1
49retinoic acid45 248.6TP53, GZMB, BCL2, BCL2L1, IL7, CD79A
50vegf457.0BCL2, IFNG, GZMB, MPO, CD79A, EPO

GO Terms for genes affiliated with Natural Killer Cell Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1T cell lineage commitmentGO:00236010.0TP53, IL7
2B cell proliferationGO:04210010.0BCL2, CD79A
3B cell lineage commitmentGO:0023269.9BCL2, TP53
4negative regulation of growth of symbiont in hostGO:0441309.9MPO, IFNG
5humoral immune responseGO:0069599.7BCL2, IL7, IFNG
6negative regulation of calcium ion transport into cytosolGO:0105239.7BCL2, EPO
7homeostasis of number of cells within a tissueGO:0488739.6BCL2, IL7, CD7
8response to salt stressGO:0096519.6EPO, TP53
9negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.5BCL2, BCL2L1
10negative regulation of anoikisGO:20008119.3BCL2, BCL2L1
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3BCL2, BCL2L1
12regulation of mitochondrial membrane permeabilityGO:0469029.2BCL2L1, BCL2, TP53
13regulation of mitochondrial membrane potentialGO:0518819.2BCL2L1, BCL2
14release of cytochrome c from mitochondriaGO:0018369.2TP53, BCL2, BCL2L1
15positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.2BCL2L1, BCL2, TP53
16negative regulation of autophagyGO:0105079.0BCL2L1, BCL2
17intrinsic apoptotic signaling pathwayGO:0971938.8TP53, BCL2, BCL2L1, GZMB
18negative regulation of apoptotic processGO:0430668.6MPO, IL7, BCL2L1, BCL2, TP53
19apoptotic processGO:0069157.6TIA1, IFNG, GZMB, EPO, BCL2L1, BCL2

Molecular functions related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2BH3 domain bindingGO:0514349.0BCL2, BCL2L1

Products for genes affiliated with Natural Killer Cell Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Natural Killer Cell Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet