ANKL
MCID: NTR003
MIFTS: 56

Natural Killer Cell Leukemia (ANKL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Natural Killer Cell Leukemia

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32MalaCards
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MalaCards: Natural Killer Cell Leukemia, also known as aggressive nk-cell leukemia, is related to leukemia and non-hodgkin lymphoma. An important gene associated with Natural Killer Cell Leukemia is GLIS2 (GLIS family zinc finger 2), and among its related pathways are TGF-Beta Pathway and 14-3-3 Induced Apoptosis. The compounds estrogen and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include nk cells, myeloid and t cells, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Natural Killer Cell Leukemia

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8Disease Ontology, 48Orphanet, 60UMLS, 42NIH Rare Diseases, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
aggressive nk-cell leukemia:
Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

natural killer cell leukemia 8
aggressive nk-cell leukemia 8 48 60
leukemia, natural killer cell large granular lymphocytic 60
large granular lymphocyte leukemia, nk-cell type 8
chronic lymphoproliferative disorder of nk-cells 60
nk-cell large granular lymphocyte leukemia 48
aggressive natural killer cell leukemia 42
aggressive non-hodgkin lymphoma 60
aggressive nk-cell lymphoma 48
aggressive nk cell leukemia 42
nk-cell lgl leukemia 48
ankcl 48
ankl 42


External Ids:

Disease Ontology8 DOID:1035
NCIt39 C8647
ICD10 via Orphanet26 C91.7
SNOMED-CT56 128833001
SNOMED-CT via Orphanet57 128833001
UMLS via Orphanet61 C1292777

Related Diseases for Natural Killer Cell Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Natural Killer Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 382)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5CD7, B3GAT1, TP53, BCL2, IL7, IFNG
2non-hodgkin lymphoma31.3IL7, GZMB, BCL2, BCL2L1
3synovitis30.8IL7
4acute leukemia30.6MPO, BCL2L1, IL7, EPO, CD7
5arthritis30.5MPO, GZMB, IFNG
6neuropathy30.5CD79A
7chronic lymphocytic leukemia30.5IL7, BCL2L1, BCL2
8vascular disease30.4BCL2L1, TP53, BCL2
9atherosclerosis30.3IL7, MPO, GZMB
10ischemia30.3MPO
11nephrotic syndrome30.3CD79A
12meningitis30.3CD79A
13hepatitis30.3GZMB
14hemophagocytic lymphohistiocytosis30.3GZMB
15myeloid leukemia30.3MPO, BCL2, BCL2L1
16peripheral vascular disease30.3MPO, CD79A
17hodgkin's lymphoma30.3BCL2L1, BCL2, GZMB, TIA1, IL7
18diabetes mellitus30.2CD79A
19hypertension30.1CD79A
20panniculitis30.1TIA1
21tuberculosis30.0IFNG, IL7, GZMB, CD79A
22rheumatoid arthritis30.0IFNG, CD79A, B3GAT1, GZMB, CD7, MPO
23peritonitis29.6MPO
24lupus erythematosus29.6CD79A
25glomerulonephritis29.6MPO, CD79A
26lichen planus29.6GZMB
27sarcoma29.6TP53, B3GAT1
28multiple sclerosis29.6IFNG, IL7, BCL2L1
29dermatitis29.6GZMB, IFNG, CD79A
30melanoma29.6BCL2L1, TP53, BCL2, IL7, GZMB, TIA1
31arthropathy10.6
32pigmented villonodular synovitis10.5
33villonodular synovitis10.5
34cerebritis10.5
35cerebral palsy10.4
36hemiplegia10.4
37spastic cerebral palsy10.4
38liver lymphoma10.4
39composite lymphoma10.4
40peripheral neuropathy10.4
41chronic nk-cell lymphocytosis10.3
42t-cell large granular lymphocyte leukemia10.3
43charcot-marie-tooth disease10.3
44tooth disease10.3
45spastic diplegia10.3
46clubfoot10.3
47osteoarthritis10.3
48hemarthrosis10.3
49lymphoid leukemia10.2
50acute myeloid leukemia10.2

Graphical network of the top 20 diseases related to Natural Killer Cell Leukemia:



Diseases related to natural killer cell leukemia

Clinical Features for Natural Killer Cell Leukemia

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Drugs & Therapeutics for Natural Killer Cell Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Natural Killer Cell Leukemia

Drug clinical trials:

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Search NIH Clinical Center for Natural Killer Cell Leukemia

Search CenterWatch for Natural Killer Cell Leukemia

Genetic Tests for Natural Killer Cell Leukemia

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Anatomical Context for Natural Killer Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to Natural Killer Cell Leukemia:

32
Nk cells, Myeloid, T cells, Bone, Monocytes, Bone marrow, B cells, Skin

Animal Models for Natural Killer Cell Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Natural Killer Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4IFNG, GLIS2, CD79A
2MP:00020069.3BCL2L1, IFNG
3MP:00107686.1TIA1, IFNG, GZMB, MPO, GLIS2, EPO
4MP:00053846.1CD79A, GLIS2, GZMB, IFNG, CD7, EPO
5MP:00053875.9MPO, GZMB, IFNG, TIA1, GLIS2, CD79A
6MP:00053975.6TP53, TIA1, IFNG, GZMB, MPO, CD79A

Publications for Natural Killer Cell Leukemia

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50PubMed
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Articles related to Natural Killer Cell Leukemia:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Adult aggressive natural killer cell leukemia. (23241562)
2013
2
Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature. (23510456)
2013
3
Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition. (23690482)
2013
4
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. (24427365)
2013
5
Endogenous IL-8 acts as a CD16 co-activator for natural killer-mediated anti-CD20 B cell depletion in chronic lymphocytic leukemia. (23259986)
2013
6
Anti-cancer activity of gemcitabine against natural killer cell leukemia/lymphoma. (23772641)
2013
7
Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication. (23037625)
2012
8
Collapsing glomerulopathy associated with natural killer cell leukemia: a case report and review of the literature. (21908087)
2011
9
T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias. (21749307)
2011
10
Natural killer-like T CD3+/CD16+CD56+ cells in chronic lymphocytic leukemia: intracellular cytokine expression and relationship with clinical outcome. (20664990)
2010
11
A child with myeloid/natural killer cell precursor acute leukemia treated successfully with acute myeloid leukemia-oriented chemotherapy incorporating L-asparaginase. (20637505)
2010
12
Interleukin-15 enhances natural killer cell cytotoxicity in patients with acute myeloid leukemia by upregulating the activating NK cell receptors. (19526239)
2010
13
Leg ulcer and thigh telangiectasia associated with natural killer cell CD56(-) large granular lymphocyte leukemia in a patient with pseudo-Felty syndrome. (19962215)
2010
14
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib. (18922853)
2009
15
2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells. (19638467)
2009
16
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: a case report of composite lymphoma. (19269751)
2009
17
A case of natural killer cell leukemia misdiagnosed as tuberculous lymphadenopathy. (19571615)
2009
18
Hypermethylation of Death-Associated Protein Kinase 1 differentiates natural killer cell lines from cell lines derived from T-acute lymphoblastic leukemia. (19212339)
2009
19
Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia. (19641183)
2009
20
Aggressive natural killer cell leukemia: is Epstein-Barr virus negativity an indicator of a favorable prognosis? (19153474)
2008
21
Aggressive natural killer cell leukemia presenting with hemophagocytic lymphohistiocytosis. (17853464)
2008
22
Cytogenetic characterization of natural killer cell leukemia. (18503833)
2008
23
Aggressive natural killer cell leukemia in a patient with common variable immunodeficiency syndrome. (16785152)
2006
24
CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. (16046525)
2005
25
Myeloid/natural killer cell precursor acute leukemia with tetraploidy. (16337859)
2005
26
Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. (15657183)
2005
27
Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1. (16019539)
2005
28
Retroviral expression screening of oncogenes in natural killer cell leukemia. (15978945)
2005
29
Aggressive Natural Killer-Cell Leukemia: report of five cases and review of the literature. (15621755)
2004
30
Aggressive natural killer cell leukemia/lymphoma: case report, use of telesynergy and review of the literature. (15360011)
2004
31
Transcription factor expression in cell lines derived from natural killer-cell and natural killer-like T-cell leukemia-lymphoma. (15369140)
2004
32
Unusual lymphoma manifestations: case 1. Natural killer cell leukemia with dermal erythema and vascular epidermal growth factor production. (14752078)
2004
33
Identification of natural killer cell receptor phenotypes associated with leukemia. (15470487)
2004
34
Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens. (12127564)
2002
35
Long-term remission induced by corticosteroids, cyclophosphamide, and methotrexate in a patient with natural killer cell leukemia. (10696134)
2000
36
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma. (10803505)
2000
37
Chronic myelomonocytic leukemia derived from a possible common progenitor of monocytes and natural killer cells. (11042523)
2000
38
Blastoid natural killer cell leukemia. (10439811)
1999
39
Acute leukemia with the phenotype of a natural killer/T cell bipotential precursor. (10037270)
1999
40
Aggressive natural killer cell leukemia: report of a case in a Caucasian boy. (9549932)
1998
41
Aggressive natural killer cell leukemia/lymphoma. (9643496)
1998
42
Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. (8599969)
1996
43
Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture. (8630414)
1996
44
Natural killer cells adhere to bone marrow fibroblasts and inhibit adhesion of acute myeloid leukemia cells. (7596192)
1995
45
Natural-killer-stimulatory effect of combined low-dose interleukin-2 and interferon beta in hairy-cell leukemia patients. (7512888)
1994
46
Interleukin 2- and interferon alpha induced natural killer cell activity as a marker of progression in hairy cell leukemia. (8348073)
1993
47
Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line. (1380031)
1992
48
Cytokine levels in aggressive natural killer cell leukemia and malignant histiocytosis. (1911378)
1991
49
Hemophagocytic syndrome associated with aggressive natural killer cell leukemia. (1746541)
1991
50
Aggressive natural killer cell leukemia/lymphoma with N901-positive surface phenotype: evidence for the existence of a third lineage in lymphoid cells. (2461636)
1988

Genetic Variations for Natural Killer Cell Leukemia

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Expression for genes affiliated with Natural Killer Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Natural Killer Cell Leukemia

Search GEO for disease gene expression data for Natural Killer Cell Leukemia.

Pathways for genes affiliated with Natural Killer Cell Leukemia

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 59Tocris Bioscience, 52R&D Systems, 55SinoBiological, 12EMD Millipore
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Pathways related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL7
2
Hide members
9.7TP53, BCL2
39.7TP53, BCL2
49.4GZMB, MPO, CD79A
59.3IFNG, BCL2, TP53
69.3BCL2L1, BCL2
79.3BCL2L1, BCL2
8
Hide members
9.3BCL2L1, BCL2
9
Hide members
9.3BCL2, BCL2L1
109.1BCL2, EPO, IFNG
119.0CD7, EPO, IL7
12
Hide members
9.0BCL2, BCL2L1, IL7
138.9IFNG, BCL2L1, BCL2
14
Hide members
8.9BCL2L1, BCL2, TP53
15
Hide members
8.9BCL2L1, BCL2, TP53
16
Hide members
8.9BCL2L1, BCL2, TP53
17
Hide members
8.9TP53, BCL2, BCL2L1
188.9TP53, BCL2, BCL2L1
19
Apoptosis and survival Apoptotic TNF-family pathways
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8.9BCL2L1, BCL2, TP53
20
Hide members
8.9TP53, BCL2, BCL2L1
218.9IFNG, BCL2L1, TP53
22
Hide members
8.9GZMB, BCL2L1, BCL2
238.9BCL2, BCL2L1, GZMB
24
Hide members
8.9BCL2, BCL2L1, GZMB
25
Development EPO-induced Jak-STAT pathway
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8.7EPO, BCL2L1, BCL2
26
Development PDGF signaling via STATs and NF-kB
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8.6BCL2, BCL2L1, MPO, IFNG
27
Hide members
8.5BCL2L1, CD79A, GZMB, IFNG
288.5TP53, BCL2L1, MPO, GZMB
298.4BCL2L1, IL7, EPO, IFNG
308.0EPO, IL7, BCL2L1, BCL2, TP53

Compounds for genes affiliated with Natural Killer Cell Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CD79A
2depsipeptide4410.2TP53
3okt3449.8IL7, IFNG, CD79A
4alpha-galactosylceramide449.8IL7, IFNG, GZMB
5cyclophosphamide44 49 1111.8IL7, BCL2, TP53
6triptolide449.7TP53, BCL2, IFNG
7cyclosporin a44 28 5911.7IFNG, GZMB, CD79A
810-hydroxycamptothecin449.3BCL2L1, BCL2, TP53
9histamine44 28 2411.3MPO, CD79A, B3GAT1, IL7, IFNG
10bax inhibitor peptide v5599.3BCL2L1, BCL2
11at 101599.3BCL2L1, BCL2
12staurosporin449.3BCL2, BCL2L1, IFNG
137-hydroxystaurosporine44 1110.3BCL2L1, TP53, BCL2
14tacrolimus44 49 1111.3GZMB, CD79A, IFNG, IL7
15chlorambucil44 1110.3BCL2L1, BCL2, TP53
16sulindac sulfide449.3BCL2, TP53, BCL2L1
17noxa449.3BCL2, BCL2L1, TP53
18cd 437449.2BCL2L1, TP53, BCL2
193-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.2IL7, BCL2, BCL2L1
20mycophenolate mofetil44 49 1111.2IFNG, CD79A, EPO
21bax channel blocker599.2BCL2L1, BCL2
22indole-3-carbinol449.2BCL2, TP53, BCL2L1
23parthenolide44 210.2BCL2L1, IFNG, TP53
24sulindac44 1110.1TP53, BCL2L1, BCL2
25dutp449.1BCL2L1, TP53, BCL2
26[alcl]449.1TIA1, BCL2L1, GZMB
27ha14-1599.0BCL2L1, BCL2
28heparin44 28 11 2412.0GZMB, B3GAT1, IL7, CD79A, MPO
29gm-csf44 2810.0BCL2L1, EPO, IFNG
30suberoylanilide hydroxamic acid449.0BCL2L1, TP53, IFNG, BCL2
31prednisolone44 28 1110.9GZMB, TIA1, MPO, CD79A, IFNG
32lactacystin448.9TP53, IFNG, BCL2, BCL2L1
33z-vad-fmk44 599.9TP53, GZMB, BCL2L1, BCL2
34carboplatin44 49 1110.9MPO, TP53, BCL2, EPO, IFNG
35oxygen44 249.8BCL2L1, EPO, MPO
36topotecan44 119.7EPO, BCL2L1, TP53, BCL2
37n acetylcysteine448.7CD79A, MPO, BCL2L1, BCL2, TP53
38arsenite44 249.7TIA1, BCL2, TP53, BCL2L1
395fluorouracil448.6TP53, BCL2, BCL2L1, IFNG, MPO
40dexamethasone44 49 28 1111.6BCL2L1, BCL2, CD79A, GZMB, IL7
41imatinib44 49 1110.6BCL2L1, BCL2, GZMB, EPO
42phosphatidylserine44 28 1110.5BCL2, BCL2L1, CD79A, GZMB, TP53
43melphalan44 119.4TP53, BCL2L1, EPO, CD79A, IFNG
44ly294002448.2BCL2, BCL2L1, EPO, GZMB, TP53
45rapamycin448.0BCL2, BCL2L1, IL7, EPO, GZMB, IFNG
46cytarabine44 49 1110.0EPO, MPO, BCL2L1, GZMB, BCL2, TP53
47cisplatin44 49 59 1110.9TP53, GZMB, MPO, EPO, BCL2L1, BCL2
48paraffin447.7TP53, BCL2L1, CD79A, MPO, GZMB, TIA1
49retinoic acid44 248.6TP53, GZMB, BCL2, BCL2L1, IL7, CD79A
50vegf447.0BCL2, IFNG, GZMB, MPO, CD79A, EPO

GO Terms for genes affiliated with Natural Killer Cell Leukemia

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16Gene Ontology
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Biological processes related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1T cell lineage commitmentGO:00236010.0TP53, IL7
2B cell proliferationGO:04210010.0BCL2, CD79A
3B cell lineage commitmentGO:0023269.9BCL2, TP53
4negative regulation of growth of symbiont in hostGO:0441309.9MPO, IFNG
5humoral immune responseGO:0069599.7BCL2, IL7, IFNG
6negative regulation of calcium ion transport into cytosolGO:0105239.7BCL2, EPO
7homeostasis of number of cells within a tissueGO:0488739.6BCL2, IL7, CD7
8response to salt stressGO:0096519.6EPO, TP53
9negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.5BCL2, BCL2L1
10negative regulation of anoikisGO:20008119.3BCL2, BCL2L1
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3BCL2, BCL2L1
12regulation of mitochondrial membrane permeabilityGO:0469029.2BCL2L1, BCL2, TP53
13regulation of mitochondrial membrane potentialGO:0518819.2BCL2L1, BCL2
14release of cytochrome c from mitochondriaGO:0018369.2TP53, BCL2, BCL2L1
15positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.2BCL2L1, BCL2, TP53
16negative regulation of autophagyGO:0105079.0BCL2L1, BCL2
17intrinsic apoptotic signaling pathwayGO:0971938.8TP53, BCL2, BCL2L1, GZMB
18negative regulation of apoptotic processGO:0430668.6MPO, IL7, BCL2L1, BCL2, TP53
19apoptotic processGO:0069157.6TIA1, IFNG, GZMB, EPO, BCL2L1, BCL2

Molecular functions related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.7TP53, BCL2
2BH3 domain bindingGO:0514349.0BCL2, BCL2L1

Products for genes affiliated with Natural Killer Cell Leukemia

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  • Antibodies
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Sources for Natural Killer Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet