MCID: NTR003
MIFTS: 45

Natural Killer Cell Leukemia

Categories: Rare diseases, Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Natural Killer Cell Leukemia

MalaCards integrated aliases for Natural Killer Cell Leukemia:

Name: Natural Killer Cell Leukemia 12 14
Aggressive Nk-Cell Leukemia 12 55
Leukemia, Natural Killer Cell Large Granular Lymphocytic 69
Large Granular Lymphocyte Leukemia, Nk-Cell Type 12
Nk-Cell Large Granular Lymphocyte Leukemia 55
Aggressive Natural Killer Cell Leukemia 49
Aggressive Natural Killer-Cell Leukemia 69
Leukemia, Large Granular Lymphocytic 69
Aggressive Nk Cell Leukemia 49
Aggressive Nk-Cell Lymphoma 55
Abnormality of the Ankles 28
Nk-Cell Lgl Leukemia 55
Ankcl 55
Ankl 49

Characteristics:

Orphanet epidemiological data:

55
aggressive nk-cell leukemia
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:1035
ICD10 32 C94.8
NCIt 46 C8647
SNOMED-CT 64 128833001
Orphanet 55 ORPHA86873
UMLS via Orphanet 70 C1292777 C1522378
ICD10 via Orphanet 33 C94.7

Summaries for Natural Killer Cell Leukemia

MalaCards based summary : Natural Killer Cell Leukemia, also known as aggressive nk-cell leukemia, is related to lichen planus and composite lymphoma, and has symptoms including fever An important gene associated with Natural Killer Cell Leukemia is GZMB (Granzyme B), and among its related pathways/superpathways are Pathways in cancer and NF-kappaB Signaling. The drugs Gemcitabine and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include nk cells, bone and t cells.

Related Diseases for Natural Killer Cell Leukemia

Diseases related to Natural Killer Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 lichen planus 31.4 GZMB IL4
2 composite lymphoma 30.3 GZMB TIA1
3 b-cell expansion with nfkb and t-cell anergy 30.0 GZMB TIA1
4 tenosynovitis of foot and ankle 11.9
5 ankle defects short stature 11.9
6 hemarthrosis 11.6
7 arthropathy 11.6
8 pigmented villonodular synovitis 11.2
9 tarsal tunnel syndrome 11.1
10 hemophilia 11.1
11 foot drop 11.0
12 mesomelic dysplasia, kantaputra type 11.0
13 exostosis 11.0
14 septic arthritis 11.0
15 navicular bone, accessory 11.0
16 buschke-ollendorff syndrome 11.0
17 osteonecrosis 11.0
18 ulcer of lower limbs 10.9
19 behcet's syndrome arthropathy 10.9
20 myopathy, distal, 1 10.9
21 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 10.9
22 arthrogryposis, distal, type 9 10.8
23 hand-foot-genital syndrome 10.8
24 bethlem myopathy 1 10.8
25 tarsal-carpal coalition syndrome 10.8
26 anemia, sideroblastic, and spinocerebellar ataxia 10.8
27 epidermolysis bullosa simplex, autosomal recessive 2 10.8
28 poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis 10.8
29 patellar tendinitis 10.8
30 emery-dreifuss muscular dystrophy 10.8
31 decubitus ulcer 10.8
32 harding ataxia 10.8
33 welander distal myopathy, swedish type 10.8
34 leukemia 10.7
35 adie pupil 10.6
36 amyloidosis, primary localized cutaneous, 1 10.6
37 atrial standstill 1 10.6
38 epiphyseal dysplasia, multiple, 1 10.6
39 erythermalgia, primary 10.6
40 larsen syndrome 10.6
41 neuropathy, hereditary sensory and autonomic, type ia 10.6
42 multicentric carpotarsal osteolysis syndrome 10.6
43 pulmonary hypertension, primary, 1 10.6
44 liebenberg syndrome 10.6
45 arthrogryposis multiplex congenita, neurogenic type 10.6
46 epiphyseal dysplasia, multiple, 4 10.6
47 mal de meleda 10.6
48 familial mediterranean fever 10.6
49 ullrich congenital muscular dystrophy 1 10.6
50 spastic ataxia, charlevoix-saguenay type 10.6

Graphical network of the top 20 diseases related to Natural Killer Cell Leukemia:



Diseases related to Natural Killer Cell Leukemia

Symptoms & Phenotypes for Natural Killer Cell Leukemia

UMLS symptoms related to Natural Killer Cell Leukemia:


fever

Drugs & Therapeutics for Natural Killer Cell Leukemia

Drugs for Natural Killer Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
2
Hydroxocobalamin Approved Phase 1, Phase 2 13422-51-0 5460373 44475014 11953898
3
Cyanocobalamin Approved, Nutraceutical Phase 1, Phase 2 68-19-9 44176380
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
5
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 143 6006
6
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 1, Phase 2 13422-55-4
7 10-deazaaminopterin Phase 1, Phase 2
8 Anti-Infective Agents Phase 1, Phase 2
9 Antimetabolites Phase 1, Phase 2
10 Antimetabolites, Antineoplastic Phase 1, Phase 2
11 Antiviral Agents Phase 1, Phase 2
12 Folic Acid Antagonists Phase 1, Phase 2
13 Hematinics Phase 1, Phase 2
14 Immunosuppressive Agents Phase 1, Phase 2
15 Micronutrients Phase 1, Phase 2
16 Trace Elements Phase 1, Phase 2
17 Vitamin B 12 Phase 1, Phase 2
18 Vitamin B Complex Phase 1, Phase 2
19 Vitamins Phase 1, Phase 2
20
Cobalamin Nutraceutical Phase 1, Phase 2 13408-78-1 6438156
21 Folate Nutraceutical Phase 1, Phase 2
22 Vitamin B12 Nutraceutical Phase 1, Phase 2
23 Vitamin B9 Nutraceutical Phase 1, Phase 2
24
Sunitinib Approved, Investigational Phase 1 341031-54-7, 557795-19-4 5329102
25
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
26
Nelfinavir Approved Phase 1 159989-64-7 64143
27 Angiogenesis Inhibitors Phase 1
28 Angiogenesis Modulating Agents Phase 1
29 Anti-HIV Agents Phase 1
30 Anti-Retroviral Agents Phase 1
31 HIV Protease Inhibitors Phase 1
32
protease inhibitors Phase 1
33
Fludarabine Approved 21679-14-1, 75607-67-9 30751
34
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
35
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
36
Mycophenolic acid Approved 24280-93-1 446541
37 Anti-Bacterial Agents
38 Antibiotics, Antitubercular
39 Antifungal Agents
40 Antirheumatic Agents
41 Antitubercular Agents
42 Calcineurin Inhibitors
43 Cyclosporins
44 Dermatologic Agents
45 Vidarabine Phosphate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
2 MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Completed NCT01231919 Phase 1 Akt inhibitor MK2206
3 Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy Completed NCT00890747 Phase 1 sunitinib malate
4 Nelfinavir Mesylate and Bortezomib in Treating Patients With Relapsed or Progressive Advanced Hematologic Cancer Completed NCT01164709 Phase 1 bortezomib;nelfinavir mesylate
5 Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer Completed NCT00112593 fludarabine phosphate;cyclosporine;mycophenolate mofetil

Search NIH Clinical Center for Natural Killer Cell Leukemia

Genetic Tests for Natural Killer Cell Leukemia

Genetic tests related to Natural Killer Cell Leukemia:

# Genetic test Affiliating Genes
1 Abnormality of the Ankles 28

Anatomical Context for Natural Killer Cell Leukemia

MalaCards organs/tissues related to Natural Killer Cell Leukemia:

38
Nk Cells, Bone, T Cells, Bone Marrow, Myeloid

Publications for Natural Killer Cell Leukemia

Articles related to Natural Killer Cell Leukemia:

(show top 50) (show all 70)
# Title Authors Year
1
Aggressive natural killer cell leukemia: a case report. ( 29263706 )
2017
2
Aggressive natural killer cell leukemia or extranodal NK/T cell lymphoma? a case with nasal involvement. ( 28623913 )
2017
3
EBV-associated aggressive natural killer cell leukemia. ( 28092886 )
2016
4
Clinicopathologic Characterization of Aggressive Natural Killer Cell Leukemia Involving Different Tissue Sites. ( 26975038 )
2016
5
A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia. ( 27566560 )
2016
6
L-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia. ( 27091029 )
2016
7
Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis. ( 27483437 )
2016
8
Aggressive natural killer cell leukemia associated with hemophagocytic lymphohistiocytosis ( 28829111 )
2016
9
Aggressive natural killer cell leukemia associated with hemophagocytic lymphohistiocytosis. ( 28829754 )
2016
10
Long complete remission achieved with the combination therapy of Cisplatin and gemcitabine in a patient with aggressive natural killer cell leukemia. ( 25694835 )
2015
11
Abnormal immunophenotype provides a key diagnostic marker: a report of 29 cases of de novo aggressive natural killer cell leukemia. ( 24524877 )
2014
12
Six cases of aggressive natural killer-cell leukemia in a Chinese population. ( 25031771 )
2014
13
Spontaneous Hepatic Rupture Associated With Epstein-Barr Virus Negative Aggressive Natural Killer Cell Leukemia. ( 29147405 )
2014
14
Aggressive natural killer-cell leukemia: classical presentation of a rare disease. ( 25118753 )
2014
15
Rare aggressive natural killer cell leukemia presented with bone marrow fibrosis - a diagnostic challenge. ( 25126488 )
2014
16
Adult aggressive natural killer cell leukemia. ( 23241562 )
2013
17
Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature. ( 23510456 )
2013
18
Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. ( 23181473 )
2013
19
Anti-cancer activity of gemcitabine against natural killer cell leukemia/lymphoma. ( 23772641 )
2013
20
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. ( 24427365 )
2013
21
Successful disease control with L-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure. ( 22891745 )
2013
22
Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation. ( 22360679 )
2012
23
Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication. ( 23037625 )
2012
24
Collapsing glomerulopathy associated with natural killer cell leukemia: a case report and review of the literature. ( 21908087 )
2011
25
Sustained CR of refractory aggressive natural killer cell leukemia following unrelated cord blood transplantation. ( 20676148 )
2010
26
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: a case report of composite lymphoma. ( 19269751 )
2009
27
A case of natural killer cell leukemia misdiagnosed as tuberculous lymphadenopathy. ( 19571615 )
2009
28
Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. ( 20046078 )
2009
29
Precursor natural killer cell leukemia. ( 17417789 )
2008
30
Cytogenetic characterization of natural killer cell leukemia. ( 18503833 )
2008
31
Aggressive natural killer cell leukemia: is Epstein-Barr virus negativity an indicator of a favorable prognosis? ( 19153474 )
2008
32
Aggressive natural killer cell leukemia presenting with hemophagocytic lymphohistiocytosis. ( 17853464 )
2008
33
Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature. ( 17261497 )
2007
34
Aggressive natural killer cell leukemia in a patient with common variable immunodeficiency syndrome. ( 16785152 )
2006
35
Retroviral expression screening of oncogenes in natural killer cell leukemia. ( 15978945 )
2005
36
Prolonged treatment response in aggressive natural killer cell leukemia. ( 16019515 )
2005
37
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. ( 14961041 )
2004
38
Aggressive natural killer cell leukemia/lymphoma: case report, use of telesynergy and review of the literature. ( 15360011 )
2004
39
Marked elevation of soluble fas ligand and cytokine secretion after splenectomy in aggressive natural killer cell leukemia/lymphoma. ( 15512819 )
2004
40
Unusual lymphoma manifestations: case 1. Natural killer cell leukemia with dermal erythema and vascular epidermal growth factor production. ( 14752078 )
2004
41
Aggressive Natural Killer-Cell Leukemia: report of five cases and review of the literature. ( 15621755 )
2004
42
Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. ( 12543867 )
2003
43
Large granular lymphocyte leukemia and natural killer cell leukemia/lymphomas. ( 12943609 )
2003
44
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma. ( 11891818 )
2002
45
Aggressive natural killer cell leukemia: clinical features and treatment outcome. ( 12495907 )
2002
46
Blastic natural killer cell leukemia/lymphoma presenting as overt leukemia. ( 11779295 )
2001
47
Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. ( 11568749 )
2001
48
Myeloid natural killer cell leukemia resembling a variant of acute promyelocytic leukemia. ( 11454535 )
2001
49
A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation. ( 10803526 )
2000
50
Long-term remission induced by corticosteroids, cyclophosphamide, and methotrexate in a patient with natural killer cell leukemia. ( 10696134 )
2000

Variations for Natural Killer Cell Leukemia

Expression for Natural Killer Cell Leukemia

Search GEO for disease gene expression data for Natural Killer Cell Leukemia.

Pathways for Natural Killer Cell Leukemia

GO Terms for Natural Killer Cell Leukemia

Cellular components related to Natural Killer Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 B3GAT1 EPO IL4 IL7 MPO
2 secretory granule GO:0030141 8.96 GZMB MPO

Biological processes related to Natural Killer Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.43 EPO IL4 IL7
2 positive regulation of B cell proliferation GO:0030890 9.16 IL4 IL7
3 positive regulation of T cell differentiation GO:0045582 8.96 IL4 IL7
4 negative regulation of apoptotic process GO:0043066 8.92 EPO IL4 IL7 MPO

Molecular functions related to Natural Killer Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL4 IL7
2 cytokine activity GO:0005125 8.8 EPO IL4 IL7

Sources for Natural Killer Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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