ANKL
MCID: NTR003
MIFTS: 57

Natural Killer Cell Leukemia (ANKL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
Download this MalaCard

Summaries for Natural Killer Cell Leukemia

About this section


Fully expand this MalaCard
MalaCards based summary: Natural Killer Cell Leukemia, also known as aggressive nk-cell leukemia, is related to peripheral vascular disease and vascular disease. An important gene associated with Natural Killer Cell Leukemia is B3GAT1 (beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)), and among its related pathways are Busulfan Pathway, Pharmacodynamics and IL2 signaling events mediated by PI3K. The compounds topotecan and okt3 have been mentioned in the context of this disorder. Affiliated tissues include nk cells, bone and bone marrow, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Aliases & Classifications for Natural Killer Cell Leukemia

About this section
Sources:
8Disease Ontology, 62UMLS, 48Orphanet, 42NIH Rare Diseases, 57SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Natural Killer Cell Leukemia, Aliases & Descriptions:

Name: Natural Killer Cell Leukemia 8 62
Aggressive Nk-Cell Leukemia 8 48 62
Leukemia, Natural Killer Cell Large Granular Lymphocytic 62
Large Granular Lymphocyte Leukemia, Nk-Cell Type 8
Chronic Lymphoproliferative Disorder of Nk-Cells 62
Nk-Cell Large Granular Lymphocyte Leukemia 48
Aggressive Natural Killer Cell Leukemia 42
 
Aggressive Natural Killer-Cell Leukemia 62
Aggressive Non-Hodgkin Lymphoma 62
Aggressive Nk Cell Leukemia 42
Aggressive Nk-Cell Lymphoma 48
Nk-Cell Lgl Leukemia 48
Ankcl 48
Ankl 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
aggressive nk-cell leukemia:
Age of onset: Adulthood; Age of death: Adult


External Ids:

Disease Ontology8 DOID:1035
NCIt39 C8647
SNOMED-CT57 128833001
ICD10 via Orphanet26 C91.7
UMLS via Orphanet63 C1292777

Related Diseases for Natural Killer Cell Leukemia

About this section

Diseases related to Natural Killer Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 343)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease30.9MPO, CD79A
2vascular disease30.4TP53, BCL2L1, BCL2
3tuberculosis30.0IL7, IFNG, CD79A
4leukemia29.9B3GAT1, BCL2L1, BCL2, IL7, IFNG, EPO
5multiple sclerosis29.8BCL2L1, IL7, IFNG
6rheumatoid arthritis29.6MPO, IFNG, IL7, B3GAT1, CD79A
7systemic lupus erythematosus29.6MPO, IFNG, CD79A
8melanoma28.9TP53, IL7, BCL2, BCL2L1, IFNG
9arthropathy10.7
10spasticity10.7
11synovitis10.6
12pigmented villonodular synovitis10.6
13villonodular synovitis10.6
14cerebritis10.5
15metanephric adenoma10.5B3GAT1
16cerebral palsy10.5
17hemiplegia10.5
18bronchitis10.5CD79A
19pleurisy10.5MPO
20thyroiditis10.5CD79A
21arthritis10.4
22spastic cerebral palsy10.4
23rhinitis10.4CD79A
24neuropathy10.4
25peripheral neuropathy10.4
26large granular lymphocyte leukemia10.4
27spastic diplegia10.4
28synovial chondromatosis10.4
29foot drop10.4
30charcot-marie-tooth disease10.4
31tooth disease10.4
32clubfoot10.3
33hypersensitivity vasculitis10.3MPO, CD79A
34immunoglobulin a vasculitis10.3CD79A, MPO
35osteoarthritis10.3
36artery disease10.3
37pneumonia10.3CD79A, MPO
38bronchiectasis10.3CD79A, MPO
39atherosclerosis10.3
40hemarthrosis10.3
41bullous pemphigoid10.3IL7, CD79A
42leukemia, acute lymphoblastic 310.3MPO, IL7
43malaria10.3IFNG
44nasopharynx carcinoma10.3TP53, CD79A
45osteochondritis dissecans10.3
46arteriosclerosis10.3
47periodontal disease10.3CD79A, MPO
48common variable immunodeficiency10.3
49hematopoietic stem cell transplantation10.3
50hemophagocytic lymphohistiocytosis10.3

Graphical network of the top 20 diseases related to Natural Killer Cell Leukemia:



Diseases related to natural killer cell leukemia

Symptoms for Natural Killer Cell Leukemia

About this section

Drugs & Therapeutics for Natural Killer Cell Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Natural Killer Cell Leukemia

Search NIH Clinical Center for Natural Killer Cell Leukemia

Genetic Tests for Natural Killer Cell Leukemia

About this section

Anatomical Context for Natural Killer Cell Leukemia

About this section

MalaCards organs/tissues related to Natural Killer Cell Leukemia:

32
Nk cells, Bone, Bone marrow, Myeloid, T cells

Animal Models for Natural Killer Cell Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Natural Killer Cell Leukemia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.3CD79A, IL7, IFNG, TP53
2MP:00020068.1BCL2L1, BCL2, IFNG, TP53
3MP:00053678.0CD79A, BCL2, IFNG, TP53
4MP:00107717.7TP53, EPO, IFNG, BCL2, BCL2L1
5MP:00053857.6MPO, TP53, EPO, IFNG, BCL2
6MP:00036317.4TP53, IFNG, BCL2, BCL2L1, B3GAT1, CD79A
7MP:00053847.3TP53, EPO, IFNG, BCL2, BCL2L1, CD79A
8MP:00053877.1MPO, TP53, IFNG, IL7, BCL2, BCL2L1
9MP:00053766.9MPO, TP53, EPO, IFNG, BCL2, BCL2L1
10MP:00107686.8MPO, TP53, EPO, IFNG, BCL2, BCL2L1
11MP:00053976.6CD79A, MPO, TP53, EPO, IFNG, IL7

Publications for Natural Killer Cell Leukemia

About this section

Articles related to Natural Killer Cell Leukemia:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Rare aggressive natural killer cell leukemia presented with bone marrow fibrosis - a diagnostic challenge. (25126488)
2014
2
Six cases of aggressive natural killer-cell leukemia in a Chinese population. (25031771)
2014
3
Aggressive natural killer-cell leukemia: classical presentation of a rare disease. (25118753)
2014
4
Abnormal immunophenotype provides a key diagnostic marker: a report of 29 cases of de novo aggressive natural killer cell leukemia. (24524877)
2014
5
Adult aggressive natural killer cell leukemia. (23241562)
2013
6
Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature. (23510456)
2013
7
Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. (23181473)
2013
8
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. (24427365)
2013
9
Anti-cancer activity of gemcitabine against natural killer cell leukemia/lymphoma. (23772641)
2013
10
Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation. (22360679)
2012
11
Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication. (23037625)
2012
12
Collapsing glomerulopathy associated with natural killer cell leukemia: a case report and review of the literature. (21908087)
2011
13
Sustained CR of refractory aggressive natural killer cell leukemia following unrelated cord blood transplantation. (20676148)
2010
14
Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (20046078)
2009
15
A case of natural killer cell leukemia misdiagnosed as tuberculous lymphadenopathy. (19571615)
2009
16
Aggressive natural killer cell leukemia: is Epstein-Barr virus negativity an indicator of a favorable prognosis? (19153474)
2008
17
Aggressive natural killer cell leukemia presenting with hemophagocytic lymphohistiocytosis. (17853464)
2008
18
Precursor natural killer cell leukemia. (17417789)
2008
19
Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature. (17261497)
2007
20
Aggressive natural killer cell leukemia in a patient with common variable immunodeficiency syndrome. (16785152)
2006
21
Retroviral expression screening of oncogenes in natural killer cell leukemia. (15978945)
2005
22
Aggressive Natural Killer-Cell Leukemia: report of five cases and review of the literature. (15621755)
2004
23
Aggressive natural killer cell leukemia/lymphoma: case report, use of telesynergy and review of the literature. (15360011)
2004
24
Marked elevation of soluble fas ligand and cytokine secretion after splenectomy in aggressive natural killer cell leukemia/lymphoma. (15512819)
2004
25
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. (14961041)
2004
26
Unusual lymphoma manifestations: case 1. Natural killer cell leukemia with dermal erythema and vascular epidermal growth factor production. (14752078)
2004
27
Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. (12543867)
2003
28
Large granular lymphocyte leukemia and natural killer cell leukemia/lymphomas. (12943609)
2003
29
Aggressive natural killer cell leukemia: clinical features and treatment outcome. (12495907)
2002
30
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma. (11891818)
2002
31
Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. (11568749)
2001
32
Blastic natural killer cell leukemia/lymphoma presenting as overt leukemia. (11779295)
2001
33
Long-term remission induced by corticosteroids, cyclophosphamide, and methotrexate in a patient with natural killer cell leukemia. (10696134)
2000
34
Aggressive natural killer cell leukemia/lymphoma: a comprehensive cytogenetic study by spectral karyotyping. (11043424)
2000
35
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma. (10803505)
2000
36
Epstein-Barr virus-infected natural killer cell leukemia. (11426629)
2000
37
Blastoid natural killer cell leukemia. (10439811)
1999
38
Interferon-gamma prevents apoptosis in Epstein-Barr virus-infected natural killer cell leukemia in an autocrine fashion. (10233902)
1999
39
Natural killer cell leukemia as a cause of peripheral neuropathy and meningitis: case report. (9710063)
1998
40
Aggressive natural killer cell leukemia: report of a case in a Caucasian boy. (9549932)
1998
41
Blastic natural killer cell leukemia/lymphoma: a clinicopathologic study. (9331296)
1997
42
Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. (8599969)
1996
43
Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. (7736391)
1995
44
Recognition of unusual presentation of natural killer cell leukemia. (7572992)
1995
45
Natural killer cell leukemia. An autopsy case. (7979914)
1994
46
Natural killer cell leukemia presenting with a peripheral neuropathy. (8414048)
1993
47
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. (1447189)
1992
48
Cytokine levels in aggressive natural killer cell leukemia and malignant histiocytosis. (1911378)
1991
49
Hemophagocytic syndrome associated with aggressive natural killer cell leukemia. (1746541)
1991
50
Hematopoiesis in patients with acute natural killer cell leukemia and large granular lymphocytosis: relationship between clinical features and hematopoietic inhibitor activity of peripheral mononuclear cells. (2806481)
1989

Variations for Natural Killer Cell Leukemia

About this section

Expression for genes affiliated with Natural Killer Cell Leukemia

About this section
Expression patterns in normal tissues for genes affiliated with Natural Killer Cell Leukemia

Search GEO for disease gene expression data for Natural Killer Cell Leukemia.

Pathways for genes affiliated with Natural Killer Cell Leukemia

About this section

Pathways related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Catalytic cycle of mammalian FMOs37
9.4BCL2, BCL2L1
2
Show member pathways
IL2 signaling events mediated by STAT537
9.4BCL2L1, BCL2
3
Show member pathways
9.4BCL2, BCL2L1
49.4BCL2, BCL2L1
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.4BCL2, BCL2L1
6
Show member pathways
9.3BCL2, IFNG
79.3IFNG, BCL2
8
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.3IFNG, BCL2L1
99.2TP53, EPO
109.1TP53, BCL2
11
Show member pathways
9.1BCL2, TP53
129.1TP53, BCL2
13
Show member pathways
9.1IL7, BCL2, BCL2L1
14
Show member pathways
EPO Receptor Signaling37
EPO signaling pathway37
9.0BCL2, EPO, BCL2L1
158.9BCL2, EPO, IFNG
16
Show member pathways
8.8BCL2L1, BCL2, IFNG
178.8IFNG, BCL2L1, BCL2
188.7BCL2L1, TP53, MPO
19
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.6TP53, BCL2, BCL2L1
208.6BCL2, TP53, BCL2L1
21
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.6BCL2L1, TP53, BCL2
22
Show member pathways
8.6BCL2L1, BCL2, TP53
23
Show member pathways
8.6BCL2, TP53, BCL2L1
24
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
8.6TP53, BCL2, BCL2L1
25
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
8.6TP53, BCL2L1, BCL2
26
Show member pathways
8.6BCL2L1, TP53, BCL2
27
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.6BCL2L1, TP53, BCL2
288.6TP53, BCL2L1, BCL2
29
Show member pathways
8.6BCL2L1, BCL2, TP53
30
Show member pathways
8.6TP53, BCL2, BCL2L1
31
Show member pathways
Type III interferon signaling37
8.5BCL2L1, EPO, IL7, IFNG
32
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5IFNG, BCL2, TP53
338.5BCL2, IFNG, TP53
348.5IFNG, TP53, BCL2
358.5BCL2L1, IFNG, TP53
36
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.4BCL2L1, MPO, BCL2, IFNG
37
Show member pathways
8.3IL7, BCL2, BCL2L1, TP53
38
Show member pathways
8.2BCL2L1, TP53, BCL2, CD79A
39
Show member pathways
8.1TP53, IFNG, BCL2, CD79A
40
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.0TP53, IFNG, BCL2, BCL2L1
417.8TP53, EPO, IL7, BCL2, BCL2L1
42
Show member pathways
7.7IFNG, TP53, EPO, IL7, BCL2
43
Show member pathways
7.2BCL2L1, BCL2, IL7, IFNG, EPO, TP53

Compounds for genes affiliated with Natural Killer Cell Leukemia

About this section

Compounds related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1topotecan44 1110.9EPO, BCL2L1
2okt3449.5CD79A, IL7, IFNG
3at 101619.4BCL2L1, BCL2
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4BCL2L1, BCL2, IL7
5methylcellulose449.3EPO, IFNG, IL7
6gm-csf44 2810.2BCL2L1, EPO, IFNG
7staurosporin449.2BCL2, BCL2L1, IFNG
8mycophenolate mofetil44 50 1111.2CD79A, IFNG, EPO
910-hydroxycamptothecin449.0BCL2, TP53, BCL2L1
107-hydroxystaurosporine44 1110.0BCL2L1, BCL2, TP53
11chlorambucil44 1110.0BCL2, TP53, BCL2L1
12z-vad-fmk44 6110.0BCL2L1, BCL2, TP53
13sulindac sulfide449.0BCL2L1, TP53, BCL2
14noxa449.0TP53, BCL2, BCL2L1
15cd 437449.0TP53, BCL2, BCL2L1
16indole-3-carbinol448.9BCL2L1, BCL2, TP53
17dutp448.9TP53, BCL2L1, BCL2
18sulindac44 119.9BCL2, BCL2L1, TP53
19depsipeptide448.9TP53, BCL2L1, BCL2
20triptolide448.9BCL2, IFNG, TP53
212-methoxyestradiol44 61 2410.8BCL2, TP53, BCL2L1
22parthenolide44 29.8TP53, IFNG, BCL2L1
23histamine44 28 2410.8B3GAT1, MPO, IFNG, IL7, CD79A
24n-(4-hydroxyphenyl)retinamide448.8TP53, BCL2, BCL2L1
25cyclophosphamide44 50 1110.8TP53, MPO, BCL2, IL7
26roscovitine448.7BCL2L1, TP53, BCL2
27oxaliplatin44 50 1110.6BCL2L1, MPO, TP53
28fludarabine44 50 1110.6BCL2L1, TP53, BCL2
29phosphatidylserine44 28 1110.6BCL2, TP53, BCL2L1, CD79A
30rapamycin448.4EPO, IFNG, IL7, BCL2L1, BCL2
31suberoylanilide hydroxamic acid448.4BCL2L1, BCL2, IFNG, TP53
32pdtc448.4TP53, BCL2L1, IFNG, BCL2
33lactacystin448.4TP53, IFNG, BCL2, BCL2L1
34dexamethasone44 50 28 1111.3BCL2, IL7, IFNG, CD79A, BCL2L1
35flavopiridol44 119.3BCL2L1, BCL2, TP53
36retinoid448.3BCL2L1, IFNG, TP53, BCL2
37n acetylcysteine448.3TP53, BCL2, BCL2L1, CD79A, MPO
38paraffin448.2TP53, BCL2, CD79A, BCL2L1, MPO
39cytarabine44 50 1110.2TP53, EPO, BCL2, MPO, BCL2L1
40h2o2448.2CD79A, BCL2L1, BCL2, TP53, MPO
41cisplatin44 50 61 1111.1TP53, BCL2L1, BCL2, EPO, MPO
42melphalan44 50 1110.1EPO, IFNG, BCL2L1, CD79A, TP53
43sb 20358044 619.1TP53, IFNG, BCL2, BCL2L1
44carboplatin44 50 1110.1MPO, TP53, BCL2, IFNG, EPO
45cycloheximide448.0IL7, BCL2L1, BCL2, TP53, IFNG
465fluorouracil448.0TP53, MPO, IFNG, BCL2L1, BCL2
47estrogen448.0TP53, IL7, BCL2, BCL2L1, B3GAT1, CD79A
48butyrate447.6IFNG, EPO, TP53, MPO, BCL2, BCL2L1
49retinoic acid44 248.3IFNG, BCL2, CD79A, BCL2L1, IL7, TP53
50vegf446.9CD79A, MPO, TP53, EPO, IFNG, IL7

GO Terms for genes affiliated with Natural Killer Cell Leukemia

About this section

Cellular components related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3IL7, IFNG, EPO, MPO
2mitochondrionGO:0057398.2BCL2L1, BCL2, TP53, MPO

Biological processes related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1homeostasis of number of cells within a tissueGO:0488739.9BCL2, IL7
2negative regulation of calcium ion transport into cytosolGO:0105239.9EPO, BCL2
3B cell proliferationGO:0421009.8BCL2, CD79A
4negative regulation of growth of symbiont in hostGO:0441309.8IFNG, MPO
5B cell receptor signaling pathwayGO:0508539.8BCL2, CD79A
6negative regulation of anoikisGO:20008119.8BCL2, BCL2L1
7negative regulation of autophagyGO:0105079.8BCL2L1, BCL2
8positive regulation of B cell proliferationGO:0308909.8IL7, BCL2
9regulation of mitochondrial membrane potentialGO:0518819.7BCL2, BCL2L1
10negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.7BCL2L1, BCL2
11T cell lineage commitmentGO:0023609.7IL7, TP53
12response to salt stressGO:0096519.6TP53, EPO
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5BCL2, BCL2L1
14B cell lineage commitmentGO:0023269.5BCL2, TP53
15ovarian follicle developmentGO:0015419.5BCL2L1, BCL2
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5BCL2L1, BCL2, IL7
17cellular response to glucose starvationGO:0421499.5TP53, BCL2
18response to ischemiaGO:0029319.5TP53, BCL2
19nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.4BCL2L1, BCL2
20cell agingGO:0075699.4TP53, BCL2
21positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.4TP53, BCL2
22humoral immune responseGO:0069599.4BCL2, IL7, IFNG
23response to gamma radiationGO:0103329.4TP53, BCL2
24response to cytokineGO:0340979.3BCL2L1, BCL2
25protein import into nucleus, translocationGO:0000609.3IFNG, TP53
26T cell differentiation in thymusGO:0330779.3TP53, BCL2
27positive regulation of cell proliferationGO:0082849.2EPO, IL7, BCL2L1
28intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1BCL2L1, BCL2
29cellular response to hypoxiaGO:0714569.0BCL2, EPO, TP53
30regulation of mitochondrial membrane permeabilityGO:0469029.0TP53, BCL2, BCL2L1
31release of cytochrome c from mitochondriaGO:0018369.0BCL2, TP53, BCL2L1
32positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.0BCL2, BCL2L1, TP53
33neuron apoptotic processGO:0514029.0BCL2, TP53, BCL2L1
34intrinsic apoptotic signaling pathwayGO:0971939.0BCL2, BCL2L1, TP53
35negative regulation of apoptotic processGO:0430668.3MPO, BCL2L1, BCL2, IL7, TP53
36apoptotic processGO:0069157.9TP53, EPO, IFNG, BCL2, BCL2L1

Molecular functions related to Natural Killer Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BH3 domain bindingGO:0514349.3BCL2L1, BCL2
2protein phosphatase 2A bindingGO:0517218.8BCL2, TP53
3protein heterodimerization activityGO:0469828.6BCL2L1, BCL2, TP53

Products for genes affiliated with Natural Killer Cell Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Natural Killer Cell Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet